Bovine respiratory disease found in animals that have been shipped or exposed to CATTLE recently transported. The major agent responsible for the disease is MANNHEIMIA HAEMOLYTICA and less commonly, PASTEURELLA MULTOCIDA or HAEMOPHILUS SOMNUS. All three agents are normal inhabitants of the bovine nasal pharyngeal mucosa but not the LUNG. They are considered opportunistic pathogens following STRESS, PHYSIOLOGICAL and/or a viral infection. The resulting bacterial fibrinous BRONCHOPNEUMONIA is often fatal.
Infections with bacteria of the genus PASTEURELLA.
The oldest recognized genus of the family PASTEURELLACEAE. It consists of several species. Its organisms occur most frequently as coccobacillus or rod-shaped and are gram-negative, nonmotile, facultative anaerobes. Species of this genus are found in both animals and humans.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria normally commensal in the flora of CATTLE and SHEEP. But under conditions of physical or PHYSIOLOGICAL STRESS, it can cause MASTITIS in sheep and SHIPPING FEVER or ENZOOTIC CALF PNEUMONIA in cattle. Its former name was Pasteurella haemolytica.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria normally found in the flora of the mouth and respiratory tract of animals and birds. It causes shipping fever (see PASTEURELLOSIS, PNEUMONIC); HEMORRHAGIC BACTEREMIA; and intestinal disease in animals. In humans, disease usually arises from a wound infection following a bite or scratch from domesticated animals.
Diseases of domestic cattle of the genus Bos. It includes diseases of cows, yaks, and zebus.
A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria that are common in the marine environment and on the surfaces and in the intestinal contents of marine animals. Some species are bioluminescent and are found as symbionts in specialized luminous organs of fish.
Skin tests in which the sensitizer is injected.
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
A species of PNEUMOVIRUS causing an important respiratory infection in cattle. Symptoms include fever, conjunctivitis, and respiratory distress.
Infection of the lung often accompanied by inflammation.
Toxins produced, especially by bacterial or fungal cells, and released into the culture medium or environment.
Substances that are toxic to cells; they may be involved in immunity or may be contained in venoms. These are distinguished from CYTOSTATIC AGENTS in degree of effect. Some of them are used as CYTOTOXIC ANTIBIOTICS. The mechanism of action of many of these are as ALKYLATING AGENTS or MITOSIS MODULATORS.
Suspensions of attenuated or killed bacteria administered for the prevention or treatment of infectious bacterial disease.
Diseases of freshwater, marine, hatchery or aquarium fish. This term includes diseases of both teleosts (true fish) and elasmobranchs (sharks, rays and skates).
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Immunoglobulins produced in a response to BACTERIAL ANTIGENS.
Toxic substances formed in or elaborated by bacteria; they are usually proteins with high molecular weight and antigenicity; some are used as antibiotics and some to skin test for the presence of or susceptibility to certain diseases.

Detection of haptoglobin in the high-density lipoprotein and the very high-density lipoprotein fractions from sera of calves with experimental pneumonia and cows with naturally occurring fatty liver. (1/62)

In addition to the lipoprotein-deficient d > 1.25 fraction, haptoglobin was detected in the high-density lipoprotein (HDL) and the very high-density lipoprotein (VHDL) fractions from sera of calves with experimental pneumonia and cows with naturally occurring fatty liver. It was not found in the chylomicrons, very low-density lipoprotein and low-density lipoprotein fractions. Washing of the HDL fraction did not decrease the haptoglobin concentration. Transferrin and immunoglobulin G were immunoblotted to examine the possibility of contamination of the lipoprotein fractions by the d > 1.25 fraction. The two serum proteins were detected only in the d > 1.25 fraction, not in any lipoprotein fractions. The distribution pattern of haptoglobin in the lipoprotein fractions was distinct from that of serum albumin. Concentrations of haptoglobin in the HDL fractions from pneumonic sera were largely proportional to those in whole sera. Cholesteryl ester concentrations were decreased in sera from calves with pneumonia, as in cows with fatty liver. A protein immunologically related to hemoglobin was also detected in particular in the VHDL fractions from sera of both groups. These results suggest that haptoglobin or a complex with the hemoglobin-like protein may have a role or roles related to the lipid metabolism.  (+info)

A comparison of florfenicol and tilmicosin for the treatment of undifferentiated fever in feedlot calves in western Canada. (2/62)

A field trial was performed under commercial feedlot conditions in western Canada to compare the efficacy of florfenicol and tilmicosin for the treatment of undifferentiated fever (UF) in calves that received metaphylactic tilmicosin upon arrival at the feedlot. One thousand and eighty recently weaned, auction market derived, crossbred beef calves suffering from UF were allocated to one of 2 experimental groups as follows: florfenicol, which was intramuscular (i.m.) florfenicol administered at the rate of 20 mg/kg body weight (BW) at the time of allocation (Day 0) and again 48 h later, or tilmicosin, which was subcutaneous (s.c.) tilmicosin administered once at the rate of 10 mg/kg BW on day 0. Five hundred and forty-four animals were allocated to the florfenicol group and 536 animals were allocated to the tilmicosin group. The chronicity, wastage, overall mortality, and bovine respiratory disease (BRD) mortality rates were significantly (P < 0.05) lower in the florfenicol group than in the tilmicosin group. There were no significant (P > or = 0.05) differences in first UF relapse, second UF relapse, hemophilosis mortality, or miscellaneous mortality rates between the florfenicol and tilmicosin groups. Average daily gain (ADG) from arrival at the feedlot to the time of implanting and ADG from allocation to the time of implanting were significantly (P < 0.05) lower in the florfenicol group as compared with the tilmicosin group. There were no significant (P > or = 0.05) differences in arrival weight, allocation weight, implanting weight, or ADG from arrival to allocation between the experimental groups. In the economic analysis, there was an advantage of $18.83 CDN per animal in the florfenicol group. The results of this study indicate that florfenicol is superior to tilmicosin for the treatment of UF because of lower chronicity, wastage, overall mortality, and BRD mortality rates. However, interpretation of these observations must take into consideration the fact that these calves received meta-phylactic tilmicosin upon arrival at the feedlot, which is a standard, cost-effective, management procedure utilized by feedlots in western Canada.  (+info)

In situ expression of intercellular adhesion molecule-1 (ICAM-1) mRNA in calves with acute Pasteurella haemolytica pneumonia. (3/62)

The in situ expression of intercellular adhesion molecule-1 (ICAM-1) mRNA in normal and pneumonic lung tissues of Holstein calves with bovine leukocyte adhesion deficiency (BLAD) was compared with that of age-matched non-BLAD Holstein calves by in situ hybridization. Twenty-four Holstein calves (both BLAD and non-BLAD) were randomly assigned to one of two experimental groups and inoculated intrabronchially with Pasteurella haemolytica or pyrogen-free saline. Lung tissues were collected and fixed in 10% neutral formalin at 2 or 4 hours postinoculation (PI). The expression and distribution of ICAM-1 mRNA in the different cell types of the lung tissue was detected by in situ hybridization with a 307-base-pair bovine ICAM-1 riboprobe. In lungs of both non-BLAD and BLAD saline-inoculated calves, ICAM-1 expression was present in epithelial cells but occurred in <30% of cells in bronchi, bronchioles, and alveoli. ICAM-1 expression in vascular endothelial cells was present in <30% of cells in pulmonary arteries and veins. The expression of ICAM-1 was significantly greater (>60% of cells) in bronchiolar and alveolar epithelial cells and pulmonary endothelial cells of arteries and veins in both BLAD and non-BLAD calves inoculated with P. haemolytica. Bronchiolar epithelium had the highest intensity of mRNA expression and highest percentage of cells that were stained, whereas bronchial epithelium had the lowest intensity and percentage of cells stained. Most alveolar macrophages and neutrophils in infected lungs also expressed ICAM-1. ICAM-1 expression was generally increased in infected BLAD calves at 2 hours PI as compared with non-BLAD calves but not at 4 hours PI. The increased expression of ICAM-1 during acute P. haemolytica pneumonia in calves suggests that ICAM-1 is upregulated and may play a role in leukocyte infiltration. The extent of ICAM-1 expression in P. haemolytica-inoculated calves with BLAD was initially enhanced but otherwise similar to that in non-BLAD calves.  (+info)

Reduced serum lecithin:cholesterol acyltransferase activity and cholesteryl ester concentration in calves experimentally inoculated with Pasteurella haemolytica and bovine herpes virus-1. (4/62)

Lecithin:cholesterol acyltransferase (LCAT), the enzyme responsible for esterification of cholesterol in plasma, is reported to be implicated in the regulation of inflammation in laboratory animals. The purpose of the present study was to elucidate the possible relevance of LCAT in the pathogenesis of calf pneumonia induced by inoculations of Pasteurella haemolytica and bovine herpes virus-1 into the calf lung. Serum LCAT activity was significantly (P < 0.01) reduced in calves inoculated with Pasteurella haemolytica. The concentration of cholesteryl esters (CE), the product of the LCAT reaction, was also decreased in the inoculated group. Decreases in LCAT activity and the CE concentration were similarly observed in calves in which bovine herpes virus-1 was inoculated. In both bacteria- and virus-inoculated calves, CE concentrations in the high-density lipoprotein fractions were distinctly decreased, whereas those in the low-density lipoprotein fractions were practically unaltered. The acute-phase proteins haptoglobin and serum amyloid A were detected in sera from the bacteria- and virus-inoculated calves; however, the two acute-phase proteins were also found in sera from the control calves. These results suggest that decreases in LCAT activity and the CE concentration are involved in the pathogenesis of pneumonia induced by inoculation of calves with Pasteurella haemolytica and bovine herpes virus-1, and also that the change in the LCAT system is more intimately related to the occurrence of calf pneumonia than the induction of acute-phase proteins such as haptoglobin.  (+info)

Decreased apolipoprotein C-III concentration in the high-density lipoprotein fraction from calves inoculated with Pasteurella haemolytica and bovine herpes virus-1. (5/62)

Lipoprotein lipid and apoprotein concentrations are known to be altered during the acute-phase response. We have previously shown that the serum activity of lecithin:cholesterol acyltransferase (LCAT) and concentration of cholesteryl esters, both constituents of the high-density lipoprotein (HDL) fraction, are reduced in calves inoculated with Pasteurella haemolytica and bovine herpes virus-1, the two major pathogens for calf pneumonia. The concentration of apolipoprotein C-III (apoC-III), a low molecular mass protein component distributed mainly in the HDL fraction, was therefore examined in bacteria- and virus-inoculated calves. An enzyme-linked immunosorbent assay demonstrated that it was decreased by inoculations of Pasteurella haemolytica and bovine herpes virus-1. The decrease was detected as early as 1 day after inoculation in both groups. A decreased serum apoC-III concentration was also observed by immunoblot analysis. It was detected in the HDL fractions from the bacteria- and virus-inoculated calves, and HDL apoC-III concentrations in the inoculated calves were decreased compared with controls. These results, coupled with the previous findings on LCAT activity and the cholesteryl ester concentration, indicate that a decreased HDL concentration is one of the early events occurring during the acute-phase response evoked by infections with Pasteurella haemolytica and bovine herpes virus-1.  (+info)

Inactivation of Pasteurella (Mannheimia) haemolytica leukotoxin causes partial attenuation of virulence in a calf challenge model. (6/62)

The leukotoxin of Pasteurella (Mannheimia) haemolytica is believed to play a significant role in pathogenesis, causing cell lysis and apoptosis that lead to the lung pathology characteristic of bovine shipping fever. Using a system for Cre-lox recombination, a nonpolar mutation within the lktC transacylase gene of the leukotoxin operon was created. The lktC locus was insertionally inactivated using a loxP-aph3-loxP cassette, and then the aph3 marker was excised from the chromosome by Cre recombinase expressed from a P. haemolytica plasmid. The resulting lktC strain (SH2099) secretes inactive leukotoxin and carries no known antibiotic resistance genes. Strain SH2099 was tested for virulence in a calf challenge model. We inoculated 3 x 10(8) or 3 x 10(9) CFU of wild-type or mutant bacteria into the lungs of healthy, colostrum-deprived calves via transthoracic injection. Animals were observed for clinical signs and for nasal colonization for 4 days, after which they were euthanized and necropsied. The lower inoculum (3 x 10(8) CFU) caused significantly fewer deaths and allowed lung pathology to be scored and compared, while the 3 x 10(9) CFU dose of either the wild-type or mutant was lethal to >/=50% of the calves. The estimated 50% lethal dose of SH2099 was four times higher than that of the wild-type strain. Lung lesion scores were reduced twofold in animals inoculated with the mutant, while clinical scores were nearly equivalent for both strains. The wild-type and mutant strains were equally capable of colonizing the upper respiratory tracts of the calves. In this study, the P. haemolytica lktC mutant was shown to be less virulent than the parent strain.  (+info)

Influence of beta(2)-integrin adhesion molecule expression and pulmonary infection with Pasteurella haemolytica on cytokine gene expression in cattle. (7/62)

beta(2)-Integrins are leukocyte adhesion molecules composed of alpha (CD11a, -b, -c, or -d) and beta (CD18) subunit heterodimers. Genetic CD18 deficiency results in impaired neutrophil egress into tissues that varies between conducting airways and alveoli of the lung. In this study, we investigated whether CD18 deficiency in cattle affects proinflammatory cytokine (PIC) expression in pulmonary tissue after respiratory infection with Pasteurella haemolytica. Cattle were infected with P. haemolytica via fiberoptic deposition of organisms into the posterior part of the right cranial lung lobe. Animals were euthanized at 2 or 4 h postinoculation (p.i.), and tissues were collected to assess PIC gene expression using antisense RNA probes specific for bovine interleukin-1alpha (IL-1alpha), IL-1beta, IL-6, gamma interferon (IFN-gamma), and tumor necrosis factor alpha (TNF-alpha) along with the beta-actin (beta-Act) housekeeping gene. Expression of PIC was induced at 2 h p.i. in P. haemolytica-infected cattle and continued to 4 h p.i. At 2 h p.i., induction of gene expression and increase of cells that expressed PIC were observed both in CD18(+) and CD18(-) cattle after inoculation of P. haemolytica. The induction of gene expression with P. haemolytica inoculation was more prominent in CD18(-) cattle than in CD18(+) cattle by comparison to pyrogen-free saline (PFS)-inoculated control animals. At 4 h p.i., however, the induction of PIC, especially IL-1alpha, IL-6, and IFN-gamma, in the lungs of CD18(+) cattle inoculated with P. haemolytica was greater than that in lungs of the CD18(-) cattle. IFN-gamma and TNF-alpha genes were not increased in P. haemolytica-inoculated CD18(-) cattle lungs compared to the PFS-inoculated control lungs at 4 h p.i. In PFS-inoculated lungs, we generally observed a higher percentage of cells and higher level of gene expression in the lungs of CD18(-) cattle than in the lungs of CD18(+) cattle, especially at 4 h p.i. The rate of neutrophil infiltration into the lungs of CD18(-) cattle at 2 h p.i. was significantly higher than that of CD18(+) cattle; at 4 h p.i., there was no difference between the two groups. These data suggest that beta(2)-integrins may contribute to the induction of expression of some PIC genes, as a consequence of P. haemolytica infection.  (+info)

Coronavirus and Pasteurella infections in bovine shipping fever pneumonia and Evans' criteria for causation. (8/62)

Respiratory tract infections with viruses and Pasteurella spp. were determined sequentially among 26 cattle that died during two severe epizootics of shipping fever pneumonia. Nasal swab and serum samples were collected prior to onset of the epizootics, during disease progression, and after death, when necropsies were performed and lung samples were collected. Eighteen normal control cattle also were sampled at the beginning of the epizootics as well as at weekly intervals for 4 weeks. Respiratory bovine coronaviruses (RBCV) were isolated from nasal secretions of 21 and 25 cattle before and after transport. Two and 17 cattle nasally shed Pasteurella spp. before and after transport, respectively. RBCV were isolated at titers of 1 x 10(3) to 1.2 x 10(7) PFU per g of lung tissue from 18 cattle that died within 7 days of the epizootics, but not from the lungs of the remaining cattle that died on days 9 to 36. Twenty-five of the 26 lung samples were positive for Pasteurella spp., and their CFU ranged between 4.0 x 10(5) and 2.3 x 10(9) per g. Acute and subacute exudative, necrotizing lobar pneumonia characterized the lung lesions of these cattle with a majority of pneumonic lung lobes exhibiting fibronecrotic and exudative changes typical of pneumonic pasteurellosis, but other lung lobules had histological changes consisting of bronchiolitis and alveolitis typical of virus-induced changes. These cattle were immunologically naive to both infectious agents at the onset of the epizootics, but those that died after day 7 had rising antibody titers against RBCV and Pasteurella haemolytica. In contrast, the 18 clinically normal and RBCV isolation-negative cattle had high hemagglutinin inhibition antibody titers to RBCV from the beginning, while their antibody responses to P. haemolytica antigens were delayed. Evans' criteria for causation were applied to our findings because of the multifactorial nature of shipping fever pneumonia. This analysis identified RBCV as the primary inciting cause in these two epizootics. These viruses were previously not recognized as a causative agent in this complex respiratory tract disease of cattle.  (+info)

Pasteurellosis, pneumonic is a specific form of pasteurellosis that is caused by the bacterium *Pasteurella multocida* and primarily affects the respiratory system. It is characterized by inflammation and infection of the lungs (pneumonia) and can result in symptoms such as cough, difficulty breathing, chest pain, fever, and decreased appetite.

This condition often occurs as a secondary infection in animals with underlying respiratory diseases, and it can be transmitted to humans through close contact with infected animals, such as through bites, scratches, or inhalation of respiratory secretions. Pneumonic pasteurellosis is more likely to occur in people who have weakened immune systems due to other health conditions.

Prompt medical treatment with antibiotics is necessary to prevent complications and improve outcomes. The prognosis for pneumonic pasteurellosis depends on the severity of the infection, the patient's overall health, and how quickly they receive appropriate medical care.

Pasteurella infections are diseases caused by bacteria belonging to the genus Pasteurella, with P. multocida being the most common species responsible for infections in humans. These bacteria are commonly found in the upper respiratory tract and gastrointestinal tracts of animals, particularly domestic pets such as cats and dogs.

Humans can acquire Pasteurella infections through animal bites, scratches, or contact with contaminated animal secretions like saliva. The infection can manifest in various forms, including:

1. Skin and soft tissue infections: These are the most common types of Pasteurella infections, often presenting as cellulitis, abscesses, or wound infections after an animal bite or scratch.
2. Respiratory tract infections: Pasteurella bacteria can cause pneumonia, bronchitis, and other respiratory tract infections, especially in individuals with underlying lung diseases or weakened immune systems.
3. Ocular infections: Pasteurella bacteria can infect the eye, causing conditions like conjunctivitis, keratitis, or endophthalmitis, particularly after an animal scratch to the eye or face.
4. Septicemia: In rare cases, Pasteurella bacteria can enter the bloodstream and cause septicemia, a severe and potentially life-threatening condition.
5. Other infections: Pasteurella bacteria have also been known to cause joint infections (septic arthritis), bone infections (osteomyelitis), and central nervous system infections (meningitis or brain abscesses) in some cases.

Prompt diagnosis and appropriate antibiotic treatment are crucial for managing Pasteurella infections, as they can progress rapidly and lead to severe complications, particularly in individuals with compromised immune systems.

"Pasteurella" is a genus of Gram-negative, facultatively anaerobic coccobacilli that are part of the family Pasteurellaceae. These bacteria are commonly found as normal flora in the upper respiratory tracts of animals, including cats, dogs, and livestock. They can cause a variety of infections in humans, such as wound infections, pneumonia, and septicemia, often following animal bites or scratches. Two notable species are Pasteurella multocida and Pasteurella canis. Proper identification and antibiotic susceptibility testing are essential for appropriate treatment.

"Mannheimia haemolytica" is a gram-negative, rod-shaped bacterium that is commonly found as part of the normal flora in the upper respiratory tract of cattle and other ruminants. However, under certain conditions such as stress, viral infection, or sudden changes in temperature or humidity, the bacteria can multiply rapidly and cause a severe respiratory disease known as shipping fever or pneumonic pasteurellosis.

The bacterium is named "haemolytica" because it produces a toxin that causes hemolysis, or the breakdown of red blood cells, resulting in the characteristic clear zones around colonies grown on blood agar plates. The bacteria can also cause other symptoms such as fever, coughing, difficulty breathing, and depression.

"Mannheimia haemolytica" is a significant pathogen in the cattle industry, causing substantial economic losses due to mortality, reduced growth rates, and decreased milk production. Prevention and control measures include good management practices, vaccination, and prompt treatment of infected animals with antibiotics.

"Pasteurella multocida" is a gram-negative, facultatively anaerobic, coccobacillus bacterium that is part of the normal flora in the respiratory tract of many animals, including birds, dogs, and cats. It can cause a variety of infections in humans, such as respiratory infections, skin and soft tissue infections, and bloodstream infections, particularly in individuals who have close contact with animals or animal bites or scratches. The bacterium is named after Louis Pasteur, who developed a vaccine against it in the late 19th century.

Cattle diseases are a range of health conditions that affect cattle, which include but are not limited to:

1. Bovine Respiratory Disease (BRD): Also known as "shipping fever," BRD is a common respiratory illness in feedlot cattle that can be caused by several viruses and bacteria.
2. Bovine Viral Diarrhea (BVD): A viral disease that can cause a variety of symptoms, including diarrhea, fever, and reproductive issues.
3. Johne's Disease: A chronic wasting disease caused by the bacterium Mycobacterium avium subspecies paratuberculosis. It primarily affects the intestines and can cause severe diarrhea and weight loss.
4. Digital Dermatitis: Also known as "hairy heel warts," this is a highly contagious skin disease that affects the feet of cattle, causing lameness and decreased productivity.
5. Infectious Bovine Keratoconjunctivitis (IBK): Also known as "pinkeye," IBK is a common and contagious eye infection in cattle that can cause blindness if left untreated.
6. Salmonella: A group of bacteria that can cause severe gastrointestinal illness in cattle, including diarrhea, dehydration, and septicemia.
7. Leptospirosis: A bacterial disease that can cause a wide range of symptoms in cattle, including abortion, stillbirths, and kidney damage.
8. Blackleg: A highly fatal bacterial disease that causes rapid death in young cattle. It is caused by Clostridium chauvoei and vaccination is recommended for prevention.
9. Anthrax: A serious infectious disease caused by the bacterium Bacillus anthracis. Cattle can become infected by ingesting spores found in contaminated soil, feed or water.
10. Foot-and-Mouth Disease (FMD): A highly contagious viral disease that affects cloven-hooved animals, including cattle. It is characterized by fever and blisters on the feet, mouth, and teats. FMD is not a threat to human health but can have serious economic consequences for the livestock industry.

It's important to note that many of these diseases can be prevented or controlled through good management practices, such as vaccination, biosecurity measures, and proper nutrition. Regular veterinary care and monitoring are also crucial for early detection and treatment of any potential health issues in your herd.

"Photobacterium" is a genus of Gram-negative, facultatively anaerobic bacteria that are capable of producing light, a phenomenon known as bioluminescence. These bacteria are commonly found in marine environments and are often associated with fish and other sea creatures. They are typically rod-shaped and can exist as free-living organisms or as symbiotic partners within host organisms. Photobacterium species are known to produce a variety of enzymes and metabolites that have potential applications in biotechnology and medicine. However, some strains of Photobacterium can cause infections in humans, particularly in individuals with weakened immune systems.

Intradermal tests are a type of allergy test that involves the injection of a small amount of allergen extract directly into the skin, usually the forearm or back. This is different from other types of allergy tests such as scratch tests or blood tests, which measure immune system responses to allergens in other ways.

During an intradermal test, a healthcare professional uses a fine needle to inject a small amount of allergen extract just beneath the surface of the skin. This creates a small wheal or bubble, and the area is then observed for signs of a reaction such as redness, swelling, or itching. These reactions indicate that the person has antibodies to the allergen and may be allergic to it.

Intradermal tests are often used when other types of allergy tests have been inconclusive or when a healthcare professional wants to confirm the results of a previous test. They can be used to diagnose a variety of allergies, including those to insect venom, medications, and environmental allergens such as pollen or mold.

It's important to note that intradermal tests carry a higher risk of causing a severe allergic reaction than other types of allergy tests, so they should only be performed by trained healthcare professionals in a medical setting where appropriate treatments are available.

"Cattle" is a term used in the agricultural and veterinary fields to refer to domesticated animals of the genus *Bos*, primarily *Bos taurus* (European cattle) and *Bos indicus* (Zebu). These animals are often raised for meat, milk, leather, and labor. They are also known as bovines or cows (for females), bulls (intact males), and steers/bullocks (castrated males). However, in a strict medical definition, "cattle" does not apply to humans or other animals.

Respiratory Syncytial Virus (RSV), bovine refers to a species-specific strain of the Respiratory Syncytial Virus that primarily infects cattle. It is a member of the Pneumoviridae family and Orthopneumovirus genus. This virus is closely related to human RSV, and it can cause respiratory infections in young calves, leading to symptoms such as nasal discharge, coughing, difficulty breathing, and pneumonia.

Bovine RSV shares many similarities with its human counterpart, including the ability to form syncytia (multinucleated giant cells) in infected tissues. However, bovine RSV is not known to infect humans or cause disease in humans. It is primarily studied as a model organism for understanding the biology and pathogenesis of RSV infections in general.

Pneumonia is an infection or inflammation of the alveoli (tiny air sacs) in one or both lungs. It's often caused by bacteria, viruses, or fungi. Accumulated pus and fluid in these air sacs make it difficult to breathe, which can lead to coughing, chest pain, fever, and difficulty breathing. The severity of symptoms can vary from mild to life-threatening, depending on the underlying cause, the patient's overall health, and age. Pneumonia is typically diagnosed through a combination of physical examination, medical history, and diagnostic tests such as chest X-rays or blood tests. Treatment usually involves antibiotics for bacterial pneumonia, antivirals for viral pneumonia, and supportive care like oxygen therapy, hydration, and rest.

Exotoxins are a type of toxin that are produced and released by certain bacteria into their external environment, including the surrounding tissues or host's bloodstream. These toxins can cause damage to cells and tissues, and contribute to the symptoms and complications associated with bacterial infections.

Exotoxins are typically proteins, and they can have a variety of effects on host cells, depending on their specific structure and function. Some exotoxins act by disrupting the cell membrane, leading to cell lysis or death. Others interfere with intracellular signaling pathways, alter gene expression, or modify host immune responses.

Examples of bacterial infections that are associated with the production of exotoxins include:

* Botulism, caused by Clostridium botulinum
* Diphtheria, caused by Corynebacterium diphtheriae
* Tetanus, caused by Clostridium tetani
* Pertussis (whooping cough), caused by Bordetella pertussis
* Food poisoning, caused by Staphylococcus aureus or Bacillus cereus

Exotoxins can be highly potent and dangerous, and some have been developed as biological weapons. However, many exotoxins are also used in medicine for therapeutic purposes, such as botulinum toxin (Botox) for the treatment of wrinkles or dystonia.

Cytotoxins are substances that are toxic to cells. They can cause damage and death to cells by disrupting their membranes, interfering with their metabolism, or triggering programmed cell death (apoptosis). Cytotoxins can be produced by various organisms such as bacteria, fungi, plants, and animals, and they can also be synthesized artificially.

In medicine, cytotoxic drugs are used to treat cancer because they selectively target and kill rapidly dividing cells, including cancer cells. Examples of cytotoxic drugs include chemotherapy agents such as doxorubicin, cyclophosphamide, and methotrexate. However, these drugs can also damage normal cells, leading to side effects such as nausea, hair loss, and immune suppression.

It's important to note that cytotoxins are not the same as toxins, which are poisonous substances produced by living organisms that can cause harm to other organisms. While all cytotoxins are toxic to cells, not all toxins are cytotoxic. Some toxins may have systemic effects on organs or tissues rather than directly killing cells.

Bacterial vaccines are types of vaccines that are created using bacteria or parts of bacteria as the immunogen, which is the substance that triggers an immune response in the body. The purpose of a bacterial vaccine is to stimulate the immune system to develop protection against specific bacterial infections.

There are several types of bacterial vaccines, including:

1. Inactivated or killed whole-cell vaccines: These vaccines contain entire bacteria that have been killed or inactivated through various methods, such as heat or chemicals. The bacteria can no longer cause disease, but they still retain the ability to stimulate an immune response.
2. Subunit, protein, or polysaccharide vaccines: These vaccines use specific components of the bacterium, such as proteins or polysaccharides, that are known to trigger an immune response. By using only these components, the vaccine can avoid using the entire bacterium, which may reduce the risk of adverse reactions.
3. Live attenuated vaccines: These vaccines contain live bacteria that have been weakened or attenuated so that they cannot cause disease but still retain the ability to stimulate an immune response. This type of vaccine can provide long-lasting immunity, but it may not be suitable for people with weakened immune systems.

Bacterial vaccines are essential tools in preventing and controlling bacterial infections, reducing the burden of diseases such as tuberculosis, pneumococcal disease, meningococcal disease, and Haemophilus influenzae type b (Hib) disease. They work by exposing the immune system to a harmless form of the bacteria or its components, which triggers the production of antibodies and memory cells that can recognize and fight off future infections with that same bacterium.

It's important to note that while vaccines are generally safe and effective, they may cause mild side effects such as pain, redness, or swelling at the injection site, fever, or fatigue. Serious side effects are rare but can occur, so it's essential to consult with a healthcare provider before receiving any vaccine.

"Fish diseases" is a broad term that refers to various health conditions and infections affecting fish populations in aquaculture, ornamental fish tanks, or wild aquatic environments. These diseases can be caused by bacteria, viruses, fungi, parasites, or environmental factors such as water quality, temperature, and stress.

Some common examples of fish diseases include:

1. Bacterial diseases: Examples include furunculosis (caused by Aeromonas salmonicida), columnaris disease (caused by Flavobacterium columnare), and enteric septicemia of catfish (caused by Edwardsiella ictaluri).

2. Viral diseases: Examples include infectious pancreatic necrosis virus (IPNV) in salmonids, viral hemorrhagic septicemia virus (VHSV), and koi herpesvirus (KHV).

3. Fungal diseases: Examples include saprolegniasis (caused by Saprolegnia spp.) and cotton wool disease (caused by Aphanomyces spp.).

4. Parasitic diseases: Examples include ichthyophthirius multifiliis (Ich), costia, trichodina, and various worm infestations such as anchor worms (Lernaea spp.) and tapeworms (Diphyllobothrium spp.).

5. Environmental diseases: These are caused by poor water quality, temperature stress, or other environmental factors that weaken the fish's immune system and make them more susceptible to infections. Examples include osmoregulatory disorders, ammonia toxicity, and low dissolved oxygen levels.

It is essential to diagnose and treat fish diseases promptly to prevent their spread among fish populations and maintain healthy aquatic ecosystems. Preventative measures such as proper sanitation, water quality management, biosecurity practices, and vaccination can help reduce the risk of fish diseases in both farmed and ornamental fish settings.

A lung is a pair of spongy, elastic organs in the chest that work together to enable breathing. They are responsible for taking in oxygen and expelling carbon dioxide through the process of respiration. The left lung has two lobes, while the right lung has three lobes. The lungs are protected by the ribcage and are covered by a double-layered membrane called the pleura. The trachea divides into two bronchi, which further divide into smaller bronchioles, leading to millions of tiny air sacs called alveoli, where the exchange of gases occurs.

Bacterial antibodies are a type of antibodies produced by the immune system in response to an infection caused by bacteria. These antibodies are proteins that recognize and bind to specific antigens on the surface of the bacterial cells, marking them for destruction by other immune cells. Bacterial antibodies can be classified into several types based on their structure and function, including IgG, IgM, IgA, and IgE. They play a crucial role in the body's defense against bacterial infections and provide immunity to future infections with the same bacteria.

Bacterial toxins are poisonous substances produced and released by bacteria. They can cause damage to the host organism's cells and tissues, leading to illness or disease. Bacterial toxins can be classified into two main types: exotoxins and endotoxins.

Exotoxins are proteins secreted by bacterial cells that can cause harm to the host. They often target specific cellular components or pathways, leading to tissue damage and inflammation. Some examples of exotoxins include botulinum toxin produced by Clostridium botulinum, which causes botulism; diphtheria toxin produced by Corynebacterium diphtheriae, which causes diphtheria; and tetanus toxin produced by Clostridium tetani, which causes tetanus.

Endotoxins, on the other hand, are components of the bacterial cell wall that are released when the bacteria die or divide. They consist of lipopolysaccharides (LPS) and can cause a generalized inflammatory response in the host. Endotoxins can be found in gram-negative bacteria such as Escherichia coli and Pseudomonas aeruginosa.

Bacterial toxins can cause a wide range of symptoms depending on the type of toxin, the dose, and the site of infection. They can lead to serious illnesses or even death if left untreated. Vaccines and antibiotics are often used to prevent or treat bacterial infections and reduce the risk of severe complications from bacterial toxins.

Additionally, rabbits were orally immunized with an edible vaccine for bovine pneumonic pasteurellosis, and there was a ...
De Alwis MCL, Jayasekera MU and Balasunderam P (1975) Pneumonic pasteurellosis in buffalo calves associated with Pasteurella ... Pasteurella and Pasteurellosis. Academic Press, London. pp. 131-160. FAO (1959) Report of the FAO meeting on haemorrhagic ... Pillai AGR, Katiyar AK, Awadhiya RP and Vegad JL (1986) An outbreak of pasteurellosis in swine. Indian Vet J 63: 527-529. De ... Pasteurellosis in production animals, an international workshop held at Bali, Indonesia, 10-13 August 1992. ACIAR Proceedings ...
"Shipping fever" (pneumonic mannheimiosis, formerly called pasteurellosis) is a disease of particular concern, that can occur as ...
Pneumonic pasteurellosis can cause high mortality in bighorn sheep, and susceptibility to the disease is higher in bighorn ...
... pasteurellosis, pneumonic MeSH C01.252.400.719 - piscirickettsiaceae infections MeSH C01.252.400.739 - pseudomonas infections ...
... pasteurellosis, pneumonic MeSH C08.730.085.660 - pneumonia, atypical interstitial, of cattle MeSH C08.730.085.675 - pneumonia ...
... pasteurellosis, pneumonic MeSH C22.196.090.660 - pneumonia, atypical interstitial, of cattle MeSH C22.196.090.675 - pneumonia ...
... pasteurellosis, pneumonic MeSH C02.782.580.600.620 - pneumovirus infections MeSH C02.782.580.600.620.750 - respiratory ...
Pneumonic Pasteurellosis: Bovine respiratory disease found in animals that have been shipped or exposed to CATTLE recently ... Pneumonic Pasteurellosis (Shipping Fever). Subscribe to New Research on Pneumonic Pasteurellosis Bovine respiratory disease ... Drugs and Important Biological Agents (IBA) related to Pneumonic Pasteurellosis: 1. VaccinesIBA 09/01/1996 - "The objective of ... 03/10/1990 - "The efficacy of long-acting oxytetracycline in the control of pneumonic pasteurellosis in lambs was tested on ...
PASTEURELLA HAEMOLYTICA AND PNEUMONIC PASTEURELLOSIS IN TRANSPORTED CATTLE (Review Article) (1-Dec-98) ...
Role of Mannheimia haemolytica leukotoxin in the pathogenesis of bovine pneumonic pasteurellosis. Anim Health Res Rev. 2002;3: ... Rudolph KM, Hunter DL, Rimler RB, Cassirer EF, Foreyt WJ, DeLong WJ, Microorganisms associated with a pneumonic epizootic in ... Epidemic pasteurellosis in a bighorn sheep population coinciding with the appearance of a domestic sheep. J Wildl Dis. 2008;44: ... Pasteurellosis. In: Williams ES, Barker IK, editors. Infectious diseases of wild mammals. Ames (IA): Iowa State University ...
Additionally, rabbits were orally immunized with an edible vaccine for bovine pneumonic pasteurellosis, and there was a ...
Test your dairy knowledge - do you know the answers to these questions? What is the common name for Pneumonic pasteurellosis? ...
A review on pneumonic pasteurellosis (respiratory mannheimiosis) with emphasis on pathogenesis, virulence mechanisms and ...
Seven strains of mice as potential models of bovine pasteurellosis following intranasal challenge with a bovine pneumonic ...
... particularly chlamydial infertility in sheep and bovine pneumonic pasteurellosis, with recent emphasis on induction of immunity ...
The objective of the current study was to isolate M. heamolytica associated with pneumonic cases of sheep in selected areas of ... Bacteriological analysis of nasal swab samples collected from a total of 76 pneumonic cases of sheep showed that M. haemolytica ... Mannheimia haemolytica has been recognized as the principal cause of pneumonic pasteurellosis in sheep and goats. It is one of ... Pneumonic pasteurellosis is primarily caused by M. haemolytica [16] and is one of the major causes of mortality in domestic ...
It causes shipping fever (see PASTEURELLOSIS, PNEUMONIC); HEMORRHAGIC BACTEREMIA; and intestinal disease in animals. In humans ...
perfringens types B, C, and D; and bovine pneumonic pasteurellosis caused by Pasteurella haemolytica type A1. ...
Pneumonic pasteurellosis is an economically important infectious disease in the small ruminant industry which causes sudden ... Thus, vaccination is an effective preventive measure to control pneumonic pasteurellosis and acute phase proteins and heat ... However, vaccinated pneumonic goats showed mild crackle lung sound while non-vaccinated pneumonic goats exhibited moderate ... This study provides new information that elucidates the potential role of pneumonic mannheimiosis in the pathogenesis of female ...
... be used for the active immunisation of sheep to reduce mortality and clinical signs of pneumonic and systemic pasteurellosis. ... The vaccine may also be used for the active immunisation of sheep to reduce mortality and clinical signs of pneumonic and ... systemic pasteurellosis. Treat your sheep with Heptavac P Plus to reduce mortality and clinical signs of lamb dysentery, pulpy ...
4) Pasteurellosis. It is primarily caused by Pasteurella haemolytica in sheep and usually occurs in pneumonic form, although a ...
1. Marru HD, Anijajo TT, Hassen AA: A study on Ovine pneumonic pasteurellosis: Isolation and Identification of Pasteurellae and ... and consolidation lesions in ovine pneumonic pasteurellosis. Vet Microbiol 2020, 248: 108823.. Search in Google Scholar ... pneumonic infection in sheep: Prevalence, clinical and pathological studies. Small Rumin Res 2006, 66(1-3): 273-277.. Search in ... 3. Goodwin KA, Jackson R, Brown C, Davies PR, Morris RS, Perkins NR: Pneumonic lesions in lambs in New Zealand: patterns of ...
In pigs, tetracyclines have been used to treat atrophic rhinitis, pneumonic pasteurellosis, Mycoplasma infections, and chronic ...
Enterotect P is used for vaccination of healthy sheep and goats as an aid in preventing pneumonic pasteurellosis caused by ... Oviguard is used for vaccination of healthy sheep and goats as an aid in preventing pneumonic pasteurellosis caused by ... For the active immunisation of sheep against pulpy kidney, malignant oedema, blackquarter, tetanus and pasteurellosis caused by ...
Pneumonic pasteurellosis, Pleuropneumonia, Swine enzootic pneumonia, Streptococcosis and Glassers disease in pig. ဆေးအသုံးပြ ...
... and as an aid in reduction of disease due to IBR and the severity of pneumonic pasteurellosis caused by Mannheimia haemolytica ... and as an aid in reduction of disease due to IBR and the severity of pneumonic pasteurellosis caused by Mannheimia haemolytica. ...
Pneumonic mannheimiosis and pasteurellosis of cattle. *Haemorrhagic septicaemia. *Pasteurellosis in sheep and goats ...
Study of the pathogenesis and development of diagnostic methods and control of pneumonic pasteurellosis in pigs. Repositório ...
Primary pneumonic plague 102040=Secondary pneumonic plague 102050=Pneumonic plague, unspecified 102080=Other specified ... Pasteurellosis 102780=Other specified zoonotic bacterial diseases 102790=Unspecified zoonotic bacterial disease 103000= ...
... pleuropneumonia and pasteurellosis have never been diagnosed in the herd. The herd is protected by strict biosecurity ... multocida type A in pneumonic lesions in pigs. However, our group has successfully developed a model to reproduce the disease ...
Agarwal, G.S.; Batra, H.V. 1996: Passive haemagglutination tests for Y. pestis infection in Surat pneumonic patients. Current ... Maity, B.; Chakraborty, A. 1996: Pasteurellosis in Siberian tiger cubs (Panthera tigris altaica). Indian Journal of Veterinary ... Chou, C.C. 1994: Pasteurella multocida related to pneumonic lungs in pigs. Taiwan Journal of Veterinary Medicine and Animal ...
pasteurellosis. homo sapiens. 9606. species. primates. pasteurella multocida. 747. species. bacteria. spotted fever due to ... pneumonic plague. homo sapiens. 9606. species. primates. yersinia pestis. 632. species. bacteria. ...
The three types of plague are the result of the route of infection: bubonic plague, septicemic plague, and pneumonic plague. ... People who have had contact with anyone infected by pneumonic plague are given prophylactic antibiotics.[14] Using the broad- ... The plague is also known to spread to the lungs and become the disease known as the pneumonic plague. ...
  • Mannheimia haemolytica has been recognized as the principal cause of pneumonic pasteurellosis in sheep and goats. (biomedcentral.com)
  • Pneumonic pasteurellosis is primarily caused by M. haemolytica [ 16 ] and is one of the major causes of mortality in domestic ruminants [ 17 ]. (biomedcentral.com)
  • However, it is unknown whether LPS endotoxin of Mannheimia haemolytica serotype A2, the principal causative bacteria that cause pneumonic mannheimiosis in small ruminants, may also induce similar insidious effects. (bvsalud.org)
  • For vaccination of healthy cattle as an aid in the prevention of disease caused by BVD Type 1, PI3 and BRSV, and as an aid in reduction of disease due to IBR and the severity of pneumonic pasteurellosis caused by Mannheimia haemolytica. (angelopellets.com)
  • This study provides new information that elucidates the potential role of pneumonic mannheimiosis in the pathogenesis of female infertility amongst small ruminants. (bvsalud.org)
  • 7. Hussain R, Mahmood F, Ali HM, Siddique AB: Bacterial, PCR and clinico-pathological diagnosis of naturally occurring pneumonic pasturellosis (mannheimiosis) during subtropical climate in sheep. (sciendo.com)
  • 6. Cid D, Pinto C, Domínguez L, Vela AI, Fernández-Garayzábal JF: Strength of association between isolation of Pasteurella multocida and consolidation lesions in ovine pneumonic pasteurellosis. (sciendo.com)
  • Pasteurella multocida pneumonic infection in sheep: Prevalence, clinical and pathological studies. (sciendo.com)
  • 3. Goodwin KA, Jackson R, Brown C, Davies PR, Morris RS, Perkins NR: Pneumonic lesions in lambs in New Zealand: patterns of prevalence and effects on production. (sciendo.com)
  • According to Ross [ 6 ], the difficulty of reproducing the disease in the absence of infectious or noninfectious cofactors is a major limitation to demonstrating the primary role of P. multocida type A in pneumonic lesions in pigs. (biomedcentral.com)
  • The objective of the current study was to isolate M. heamolytica associated with pneumonic cases of sheep in selected areas of Central Ethiopia, determine its role and the strains/genotypes of the bacterium circulating in the study area. (biomedcentral.com)
  • Bibersteinia trehalosi T3, T4, T10, and T15 have been most often associated with the systemic or septicemic form of pasteurellosis affecting lambs. (msdvetmanual.com)
  • pneumonic , septicemic , and bubonic . (mdwiki.org)
  • It is the cause of epizootic pneumonia in cattle known as pneumonic pasteurellosis (also shipping fever or transit fever). (geneticpcr.com)
  • The fact that very many lower tract infections were made - even in clinically normal, non-pneumonic cattle - is discussed in relation to the findings of other workers. (gla.ac.uk)
  • Lobar pneumonia affects large areas of lobes and is often severe (eg, fibrinous pneumonic pasteurellosis of cattle). (msdvetmanual.com)
  • [16] pPla codes for a protease , Pla, that activates plasmin in human hosts and is a very important virulence factor for pneumonic plague. (mdwiki.org)
  • lincomycin and oxytetracycline disposition in calves with experimental pneumonic pasteurellosis. (tamu.edu)
  • In fact, apart from the calves that underwent a "natural" outbreak of pneumonic pasteurellosis, the presence of recognised pulmonary pathogens was not widespread. (gla.ac.uk)
  • Pasteurellosis of sheep and goats commonly refers to bacterial infections of the lower respiratory tract. (msdvetmanual.com)
  • 37 Nevertheless, infections with multiple strains may occur within herds associated with increased severity of pneumonic lesions at slaughter, suggesting that reducing the number of different strains may lead to fewer lung lesions at slaughter and better respiratory health of pigs. (anipedia.org)
  • To quickly reduce fever in infectious diseases such as pneumonic pasteurellosis and other pneumonias, piroplasmosis, anaplasmosis, salmonellosis, etc. (horsesandcamelsupplies.com)

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