A multisystemic disorder characterized by a sensorimotor polyneuropathy (POLYNEUROPATHIES), organomegaly, endocrinopathy, monoclonal gammopathy, and pigmentary skin changes. Other clinical features which may be present include EDEMA; CACHEXIA; microangiopathic glomerulopathy; pulmonary hypertension (HYPERTENSION, PULMONARY); cutaneous necrosis; THROMBOCYTOSIS; and POLYCYTHEMIA. This disorder is frequently associated with osteosclerotic myeloma. (From Adams et al., Principles of Neurology, 6th ed, p1335; Rev Med Interne 1997;18(7):553-62)
An abnormal hardening or increased density of bone tissue.
Large benign, hyperplastic lymph nodes. The more common hyaline vascular subtype is characterized by small hyaline vascular follicles and interfollicular capillary proliferations. Plasma cells are often present and represent another subtype with the plasma cells containing IgM and IMMUNOGLOBULIN A.
Literary and oral genre expressing meaning via symbolism and following formal or informal patterns.
A characteristic symptom complex.
The presence of chyle in the thoracic cavity. (Dorland, 27th ed)
A lyophilized preparation of a low-virulence strain (SU) of Streptococcus pyogenes (S. hemolyticus), inactivated by heating with penicillin G. It has been proposed as a noncytotoxic antineoplastic agent because of its immune system-stimulating activity.
Diseases of multiple peripheral nerves simultaneously. Polyneuropathies usually are characterized by symmetrical, bilateral distal motor and sensory impairment with a graded increase in severity distally. The pathological processes affecting peripheral nerves include degeneration of the axon, myelin or both. The various forms of polyneuropathy are categorized by the type of nerve affected (e.g., sensory, motor, or autonomic), by the distribution of nerve injury (e.g., distal vs. proximal), by nerve component primarily affected (e.g., demyelinating vs. axonal), by etiology, or by pattern of inheritance.
A group of related diseases characterized by an unbalanced or disproportionate proliferation of immunoglobulin-producing cells, usually from a single clone. These cells frequently secrete a structurally homogeneous immunoglobulin (M-component) and/or an abnormal immunoglobulin.
An alkylating nitrogen mustard that is used as an antineoplastic in the form of the levo isomer - MELPHALAN, the racemic mixture - MERPHALAN, and the dextro isomer - MEDPHALAN; toxic to bone marrow, but little vesicant action; potential carcinogen.

Human herpesvirus 8 infection in patients with POEMS syndrome-associated multicentric Castleman's disease. (1/80)

The polyneuropathy, organomegaly, endocrinopathy, M protein, skin changes (POEMS) syndrome is a rare multisystemic disorder associated with osteosclerotic myeloma and multicentric Castleman's disease (MCD). Human herpesvirus type 8 (HHV-8) DNA sequences have been detected in lymph nodes of about 40% of human immunodeficiency virus (HIV)-negative patients with MCD, and in bone marrow stromal cells of patients with multiple myeloma. Considering these data, we investigated the presence of HHV-8 in 18 patients with POEMS syndrome (9 with MCD), by nested polymerase chain reaction (N-PCR) to detect DNA sequenses in various cells and tissues obtained by biopsy or at autopsy (13 patients, of whom 7 had MCD), and by an immunofluorescence assay to detect anti-HHV-8 IgG antibodies in blood (18 patients, of whom 9 had MCD). Detection of HHV-8 DNA was performed using three different N-PCR, targeting nonoverlapping regions in open reading frame (ORF) 25 and ORF26. Seven of 13 (54%) POEMS patients had HHV-8 DNA sequences in their tissues, as assessed by all three N-PCR, and 9 of 18 (50%) had circulating anti-HHV-8 antibodies. HHV-8 was mainly detected in the subset of POEMS patients with MCD (6 of 7 [85%] for DNA sequences; 7 of 9 [78%] for antibodies). The percentage of positive N-PCR was higher in lymph nodes than in bone marrow samples (P <.02). Sequencing of amplicons showed a homogeneous restricted variability in the ORF26 region, characteristic of the minority subgroup B defined by Zong, and responsible for isoleucine and glycine substitutions at amino acid positions 134 and 167. These findings strongly suggest an association of HHV-8 infection with POEMS syndrome-associated MCD.  (+info)

A spectrum of clinicopathological features of nephropathy associated with POEMS syndrome. (2/80)

BACKGROUND: In POEMS syndrome, substantial involvement of the kidney can occur and is reflected by proteinuria, haematuria, renal dysfunction, and renal failure requiring dialysis therapy. The mechanism by which renal dysfunction is induced and progresses to end-stage renal disease remains obscure. A pathogenic role of cytokines and growth factors has recently been implicated. METHODS: We reviewed cases of 52 Japanese patients with confirmed renal pathology who were reported in the literature, and personally analysed renal tissues from 22 subjects including nine patients of our own. Interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) were measured in our cases. RESULTS: Despite relatively mild renal symptomatology, about half of the cases had azotaemia with creatinine levels above 1.5 mg/dl and the BUN/creatinine ratio markedly raised by volume contraction or wasting. One-tenth of patients were placed on haemodialysis because of advanced or end-stage renal disease. Bilateral and unilateral contracted kidneys were found in four and two cases respectively. Pathological analyses disclosed two major changes: glomerular alterations and endarteritis-like lesions of renal small arteries. The former included glomerular enlargement, cellular proliferation, mesangiolysis and marked swelling of endothelial-mesangial cells. This structural disorganization led to a reduction in renal function to some degree by impairing the glomerular circulation. Vasculopathy of the small artery probably resulted in progressive renal damage and ultimately to kidney contraction. Serum IL-6 was elevated in about 40% of cases. IL-6 levels were found to be high in the ascites of three patients who were examined. In different studies, an increased level of VEGF was found in the peripheral blood (75-100%; overall 92.3%), but no apparent correlation with glomerular alterations was observed. CONCLUSION: POEMS nephropathy can be one cause of end-stage renal disease with variable intrarenal pathological changes of a microangiopathic nature which have differential influences on renal function. A pathogenic role for VEGF in POEMS syndrome appears to be likely, but its causal relation to the nephropathy awaits further investigation.  (+info)

VEGF is causative for pulmonary hypertension in a patient with Crow-Fukase (POEMS) syndrome. (3/80)

We report a case of Crow-Fukase (POEMS) syndrome associated with pulmonary hypertension (PH). In this case, the concentration of vascular endothelial growth factor (VEGF) was extremely high in the serum, and the levels of IL-1beta, IL-6, TNF-alpha, and thiamine, which were thought in past reports to be mediators of PH in Crow-Fukase syndrome, were normal. After prednisolone therapy, PH disappeared with a dramatic decrease in serum VEGF. Our results suggest that VEGF is closely correlated with PH in Crow-Fukase syndrome.  (+info)

Crow-Fukase syndrome with ischemic cardiomyopathy. (4/80)

A 31-year-old man was admitted to our hospital for further evaluation of heart failure symptoms. Crow-Fukase syndrome was diagnosed on the basis of findings of polyneuropathy, hepatomegaly, monoclonal hypergammaglobulinemia, and hypertrichosis. Dipyridamole-stress thallium-201 perfusion imaging, contrast left ventriculography, and coronary angiography revealed a markedly dilated and dysfunctioning left ventricle, extensive reversible ischemia with fixed defect, and multiple coronary lesions. Histopathology of myocardial biopsy specimens demonstrated ischemia-induced myocardial necrosis. These findings suggested that ischemic cardiomyopathy, probably due to inflammatory reactions of coronary arteries in Crow-Fukase syndrome, was responsible for the heart failure symptoms and left ventricular dysfunction in this patient.  (+info)

Successful treatment of POEMS syndrome with autologous hematopoietic progenitor cell transplantation. (5/80)

POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) is a plasma cell dyscrasia that differs substantially from classic multiple myeloma. It is often associated with disabling polyneuropathy in younger patients. Current therapeutic approaches are frequently inadequate and leave many patients wheelchair-bound with significant deterioration in quality and length of life. We present the case of a young man with progressive disease despite conventional therapeutic approaches. We describe a novel approach to treatment with a bone-seeking radiopharmaceutical, samarium-153 ethylene diamine tetramethylene phosphonate ((153)Sm-EDTMP), followed by myeloablative chemotherapy with autologous hematopoietic progenitor cell reconstitution. This approach resulted in regression of the organomegaly and skin changes and in neurologic improvement both clinically and electrophysiologically. The patient progressed from being wheelchair-bound to independent ambulation. An aggressive approach should be considered in patients with POEMS syndrome in whom standard therapeutic measures fail.  (+info)

An autopsy case of POEMS syndrome with a high level of IL-6 and VEGF in the serum and ascitic fluid. (6/80)

A 45-year-old woman was hospitalized because of systemic edema and peripheral nerve impairment. The patient had complications of organomegaly, endocrinopathy, and monoclonal gammmopathy, and was diagnosed with POEMS syndrome based on these characteristic signs and symptoms. Interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) levels in the serum and ascitic fluid were high. Many of the patient's symptoms were ameliorated, and IL-6 and VEGF levels in the serum and ascitic fluid decreased slightly during chemotherapy, but she died of respiratory failure. Autopsy revealed severe systemic edema and macroscopic hemorrhage in many organs, but VEGF and IL-6 producing cells were not found.  (+info)

High-dose therapy and autologous blood stem cell transplantation in POEMS syndrome. (7/80)

We treated 5 patients with polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome and multifocal bone lesions or diffuse bone marrow plasmacytic infiltration with high-dose therapy (HDT) and autologous blood stem cell transplantation. In all cases, the treatment produced remission of plasma cell proliferation associated with marked improvement in the patients' performance status, neurologic symptoms, and other manifestations of the syndrome. HDT with stem cell support should be investigated further as a therapeutic option in patients with POEMS syndrome and disseminated plasma cell dyscrasia.  (+info)

Crow-Fukase syndrome associated with high-output heart failure. (8/80)

A 64-year-old woman was admitted with systemic edema and exertional dyspnea. High-output heart failure was diagnosed by right heart catheterization and she was treated with diuretics. After 3 weeks, her symptoms disappeared but a high cardiac output state persisted. A diagnosis of Crow-Fukase syndrome was made based on the presence of polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes. Her serum vascular endothelial growth factor (VEGF) level was markedly elevated after recovery from heart failure. We suspect that an elevated VEGF level and a high cardiac output state may play a role in the pathogenesis of heart failure in Crow-Fukase syndrome.  (+info)

POEMS syndrome is a rare and complex disorder that affects multiple parts of the body. The name POEMS is an acronym that stands for the following symptoms: Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy, and Skin changes.

Here's a brief definition of each component of the syndrome:

* Polyneuropathy: This refers to damage to the peripheral nerves that can cause symptoms such as numbness, tingling, pain, and weakness in the arms and legs.
* Organomegaly: This means enlargement of organs, such as the liver, spleen, or lymph nodes.
* Endocrinopathy: This refers to abnormalities in hormone-producing glands, which can lead to symptoms such as diabetes, low testosterone levels, and thyroid dysfunction.
* Monoclonal gammopathy: This is an abnormal production of a single type of immunoglobulin (a protein produced by the immune system) in the bone marrow.
* Skin changes: These can include skin thickening, darkening, or redness, as well as skin lesions.

POEMS syndrome is typically caused by an underlying plasma cell disorder, such as multiple myeloma or a related condition called Waldenstrom macroglobulinemia. Treatment for POEMS syndrome usually involves addressing the underlying plasma cell disorder, as well as managing specific symptoms of the syndrome.

Osteosclerosis is a medical term that refers to an abnormal thickening and increased density of bone tissue. This condition can occur as a result of various diseases or conditions, such as certain types of bone cancer, Paget's disease of bone, fluoride poisoning, or chronic infection of the bone. Osteosclerosis can also be seen in some benign conditions, such as osteopetrosis, which is a rare genetic disorder characterized by an excessively hard and dense skeleton.

In some cases, osteosclerosis may not cause any symptoms and may only be discovered on X-rays or other imaging studies. However, in other cases, it can lead to complications such as bone pain, fractures, or deformities. Treatment for osteosclerosis depends on the underlying cause of the condition and may include medications, surgery, or other therapies.

Giant lymph node hyperplasia, also known as Castlemans disease, is a rare benign condition characterized by the abnormal enlargement of lymph nodes due to an overgrowth of cells. It can affect people of any age but is more commonly seen in young adults and children.

The enlarged lymph nodes caused by this condition are typically round, firm, and mobile, and they may be found in various locations throughout the body, including the neck, chest, abdomen, and pelvis. In some cases, the enlarged lymph nodes may cause symptoms such as pain, pressure, or difficulty swallowing, depending on their location.

Giant lymph node hyperplasia can be classified into two main types: unicentric and multicentric. Unicentric Castleman's disease affects a single group of lymph nodes, while multicentric Castleman's disease affects multiple groups of lymph nodes throughout the body.

The exact cause of giant lymph node hyperplasia is not fully understood, but it is thought to be related to an overactive immune response. In some cases, it may be associated with viral infections such as HIV or HHV-8. Treatment for this condition typically involves surgical removal of the affected lymph nodes, along with medications to manage any associated symptoms and prevent recurrence.

I'm sorry for any confusion, but "Poetry as Topic" is not a term that has a specific medical definition. It seems to be a subject that falls under the humanities or arts, rather than being a medical concept. Poetry can sometimes be used in therapeutic settings as a form of expressive art therapy, but it is not a medical diagnosis or treatment. If you have any questions related to medicine or health, I'd be happy to try and help answer those for you!

A syndrome, in medical terms, is a set of symptoms that collectively indicate or characterize a disease, disorder, or underlying pathological process. It's essentially a collection of signs and/or symptoms that frequently occur together and can suggest a particular cause or condition, even though the exact physiological mechanisms might not be fully understood.

For example, Down syndrome is characterized by specific physical features, cognitive delays, and other developmental issues resulting from an extra copy of chromosome 21. Similarly, metabolic syndromes like diabetes mellitus type 2 involve a group of risk factors such as obesity, high blood pressure, high blood sugar, and abnormal cholesterol or triglyceride levels that collectively increase the risk of heart disease, stroke, and diabetes.

It's important to note that a syndrome is not a specific diagnosis; rather, it's a pattern of symptoms that can help guide further diagnostic evaluation and management.

Chylothorax is a medical condition characterized by the accumulation of lymphatic fluid called chyle in the pleural space, which is the space between the lungs and the chest wall. Chyle is a milky-white fluid that contains nutrients, electrolytes, and immune cells, and it is normally transported through the thoracic duct to the bloodstream.

Chylothorax can occur due to various reasons, such as trauma, surgery, tumors, or congenital abnormalities that disrupt the normal flow of chyle. As a result, chyle leaks into the pleural space, causing symptoms such as cough, chest pain, difficulty breathing, and fever.

The diagnosis of chylothorax is usually made through imaging studies such as chest X-ray or CT scan, and confirmed by analyzing the fluid for the presence of chylomicrons, which are lipid particles found in chyle. The treatment options for chylothorax include dietary modifications, such as a low-fat diet with medium-chain triglycerides, chest tube drainage, and surgical interventions such as thoracic duct ligation or pleurodesis.

Picibanil is not a commonly used medical term, and it may be more familiar as the brand name for a specific preparation of Group A Streptococcus OK-432. It is an immunotherapeutic agent that has been used in Japan for the treatment of certain types of cancer, such as nasopharyngeal carcinoma and soft tissue sarcoma.

Group A Streptococcus OK-432 is a weakened form of a bacterium that causes strep throat. When administered, it stimulates the immune system to produce cytokines, which are substances that help regulate the immune response. This can enhance the body's ability to fight off cancer cells and potentially slow or stop tumor growth.

It is important to note that Picibanil/OK-432 is not approved for use in the United States and its effectiveness as a cancer treatment has not been extensively studied outside of Japan.

Polyneuropathy is a medical condition that refers to the damage or dysfunction of peripheral nerves (nerves outside the brain and spinal cord) in multiple areas of the body. These nerves are responsible for transmitting sensory, motor, and autonomic signals between the central nervous system and the rest of the body.

In polyneuropathies, this communication is disrupted, leading to various symptoms depending on the type and extent of nerve damage. Commonly reported symptoms include:

1. Numbness or tingling in the hands and feet
2. Muscle weakness and cramps
3. Loss of reflexes
4. Burning or stabbing pain
5. Balance and coordination issues
6. Increased sensitivity to touch
7. Autonomic dysfunction, such as bowel, bladder, or digestive problems, and changes in blood pressure

Polyneuropathies can be caused by various factors, including diabetes, alcohol abuse, nutritional deficiencies, autoimmune disorders, infections, toxins, inherited genetic conditions, or idiopathic (unknown) causes. The treatment for polyneuropathy depends on the underlying cause and may involve managing underlying medical conditions, physical therapy, pain management, and lifestyle modifications.

Paraproteinemias refer to the presence of abnormal levels of paraproteins in the blood. Paraproteins are immunoglobulins (antibodies) produced by plasma cells, which are a type of white blood cell found in the bone marrow. In healthy individuals, paraproteins play a role in the immune system's response to infection and disease. However, in certain conditions, such as multiple myeloma, monoclonal gammopathy of undetermined significance (MGUS), and Waldenstrom macroglobulinemia, plasma cells produce excessive amounts of a single type of paraprotein, leading to its accumulation in the blood.

Paraproteinemias can cause various symptoms depending on the level of paraproteins present and their impact on organs and tissues. These symptoms may include fatigue, weakness, numbness or tingling in the extremities, bone pain, recurrent infections, and kidney problems. In some cases, paraproteinemias may not cause any symptoms and may only be detected during routine blood tests.

It is important to note that while paraproteinemias are often associated with plasma cell disorders, they can also occur in other conditions such as chronic inflammation or autoimmune diseases. Therefore, further testing and evaluation are necessary to determine the underlying cause of paraproteinemia and develop an appropriate treatment plan.

Melphalan is an antineoplastic agent, specifically an alkylating agent. It is used in the treatment of multiple myeloma and other types of cancer. The medical definition of Melphalan is:

A nitrogen mustard derivative that is used as an alkylating agent in the treatment of cancer, particularly multiple myeloma and ovarian cancer. Melphalan works by forming covalent bonds with DNA, resulting in cross-linking of the double helix and inhibition of DNA replication and transcription. This ultimately leads to cell cycle arrest and apoptosis (programmed cell death) in rapidly dividing cells, such as cancer cells.

Melphalan is administered orally or intravenously, and its use is often accompanied by other anticancer therapies, such as radiation therapy or chemotherapy. Common side effects of Melphalan include nausea, vomiting, diarrhea, and bone marrow suppression, which can lead to anemia, neutropenia, and thrombocytopenia. Other potential side effects include hair loss, mucositis, and secondary malignancies.

It is important to note that Melphalan should be used under the close supervision of a healthcare professional, as it can cause serious adverse reactions if not administered correctly.

... (also termed osteosclerotic myeloma, Crow-Fukase syndrome, Takatsuki disease, or PEP syndrome) is a rare ... Neuropathy can occur in CD patients with or without POEMS syndrome. CD and POEMS tend to overlap, with roughly 15-24% of POEMS ... affected by POEMS syndrome. The diagnosis of POEMS syndrome is based on meeting its two mandatory criteria, meeting at least ... Some features have been observed in patients with POEMS syndrome but are not yet certain to form part of the syndrome itself. ...
Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome which is a ... Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have ... Dispenzieri A (November 2007). "POEMS syndrome". Blood Rev. 21 (6): 285-299. doi:10.1016/j.blre.2007.07.004. PMID 17850941. ...
Dispenzieri A (2015). "POEMS syndrome: update on diagnosis, risk-stratification, and management". American Journal of ... Kourelis TV, Dispenzieri A (2017). "Validation of a prognostic score for patients with POEMS syndrome: a mayo clinic cohort". ... "UpToDate". Warsame R, Yanamandra U, Kapoor P (2017). "POEMS Syndrome: an Enigma". Current Hematologic Malignancy Reports. 12 (2 ... POEMS is an acronym standing for the characteristic signs or symptoms of the syndrome: Polyneuropathy, Organomegaly, ...
"POEMS syndrome: definitions and long-term outcome". Blood. 101 (7): 2496-506. doi:10.1182/blood-2002-07-2299. PMID 12456500. ... Some, such as chronic fatigue syndrome, are controversial. These conditions are included here because they are frequently ... Murinson BB (2004). "Stiff-person syndrome". Neurologist. 10 (3): 131-7. doi:10.1097/01.nrl.0000126587.37087.1a. PMID 15140273 ... "Immune complexes and the pathogenesis of neutropenia in Felty's syndrome". Annals of the Rheumatic Diseases. 45 (8): 696-702. ...
He died of POEMS syndrome in 2012. Sue Book (Dec 5, 2012). "Former Trent Woods mayor, legislator dies". Sun Journal. "A NC ...
Lisa Kindred, 79, American folk musician, POEMS syndrome. Winston Lackin, 64, Surinamese politician, Minister of Foreign ...
"Glomeruloid hemangioma in POEMS syndrome shows two different immunophenotypic endothelial cells". Cutaneous Pathology. 27 (2): ... As--the mostly juvenile--Waterhouse Friedrichsen Syndrome is caused by adrenal bleeding from bacterial infections, the 'senile ...
In patients who have both POEMS-associated MCD, treatment should be directed at the POEMS syndrome. HHV-8-associated MCD ... There is no evidence of POEMS syndrome, HHV-8, or any other cancer or infectious disease. Though all forms of MCD involve ... A cancerous cell population found in patients with POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal ... If symptoms are due to an inflammatory syndrome, then anti-interleukin-6 (IL-6) therapy is recommended. If these treatments are ...
Michael A. Gorman, 62, American politician, member of the North Carolina House of Representatives (2003-2005), POEMS syndrome. ... Nakamura Kanzaburō XVIII, 57, Japanese kabuki star, acute respiratory distress syndrome. Dame Elisabeth Murdoch, 103, ...
Kindred died in San Rafael, California on November 11, 2019 at the age of 79 from POEMS syndrome. 1964: "New Folks Volume 2" ( ...
... is a distinctive vascular tumor first described in 1990 when found to be associated with POEMS syndrome ...
... skin changes syndrome (POEMS syndrome), or by distinct clinical features, such as thrombocytopenia, anasarca, myelofibrosis, ... While iMCD with TAFRO syndrome was first described in Japanese patients in 2010, cases of iMCD with TAFRO syndrome have since ... Compared to iMCD patients without TAFRO syndrome, iMCD patients with TAFRO syndrome are more likely to present with severe ... iMCD patients with thrombocytopenia, anasarca, myelofibrosis, renal dysfunction, and organomegaly syndrome (TAFRO syndrome) are ...
... she was suffering from POEMS Syndrome, which can cause nerve damage, organ enlargement, hormonal imbalances, and skin changes. ...
Metal fume fever Milk protein allergy Myotonic dystrophy Nonbacterial osteitis Organic dust toxic syndrome Panniculitis POEMS ( ... Sweet syndrome (acute febrile neutrophilic dermatosis) Thrombosis Tubulointerstitial nephritis and uveitis syndrome (TINU) ... Polymer fume fever Post-cardiac injury syndrome Postmyocardial infarction syndrome Primary biliary cirrhosis Primary ... Immune reconstitution inflammatory syndrome is a common cause of FUO when a previously suppressed immune system is re-activated ...
... tissue disease such as lupus Immunosuppression following organ transplantation Guillain-Barré syndrome Tempi syndrome POEMS ... Sykes, David B.; Schroyens, Wilfried; O'Connell, Casey (2011). "TEMPI Syndrome - A Novel Multisystem Disease". N Engl J Med. ...
Schnitzler syndrome MeSH C20.683.780.650 - multiple myeloma MeSH C20.683.780.750 - POEMS syndrome MeSH C20.683.780.925 - ... Guillain-Barré syndrome MeSH C20.111.258.750.400.500 - Miller Fisher syndrome MeSH C20.111.258.750.600 - hereditary sensory and ... Sézary syndrome MeSH C20.683.515.950 - tumor lysis syndrome MeSH C20.683.780.250 - cryoglobulinemia MeSH C20.683.780.490 - ... stiff-person syndrome MeSH C20.111.258.925 - uveomeningoencephalitic syndrome MeSH C20.111.258.962 - vasculitis, central ...
... a poem by Marianne Moore a tool for packaging and dependency management in Python POEMS syndrome, a medical condition All pages ... a series of poems written in 1847 by Ralph Waldo Emerson Poems (William Golding), the first work by William Golding Poems ( ... Poems (William Carlos Williams), an early self-published volume of poems by William Carlos Williams Poems (Sextus Propertius), ... Hesse), a collection of 31 poems written by Hermann Hesse Poems (Wilfred Owen), a 1920 posthumous poetry collection Poems ( ...
... for Oxfam whilst raising awareness of those battling cancer and widening awareness of a rare illness called POEMS Syndrome". ...
POEMS syndrome MeSH C16.131.077.730 - Prader-Willi syndrome MeSH C16.131.077.740 - proteus syndrome MeSH C16.131.077.745 - ... MeSH C16.131.077.065 - Alagille syndrome MeSH C16.131.077.095 - Angelman syndrome MeSH C16.131.077.112 - Bardet-Biedl syndrome ... branchio-oto-renal syndrome MeSH C16.131.260.190 - cri du chat syndrome MeSH C16.131.260.210 - De Lange syndrome MeSH C16.131. ... branchio-oto-renal syndrome MeSH C16.320.180.190 - cri du chat syndrome MeSH C16.320.180.210 - De Lange syndrome MeSH C16.320. ...
... due to elevated protein levels POEMS syndrome, a paraneoplastic syndrome that can cause increased intracranial pressure. Foster ... Hyperammonemia, elevated level of ammonia in blood (including cerebral edema/intracranial pressure) Guillain-Barré syndrome, ... Kennedy syndrome (FKS) Chiari malformation Tumors of the frontal lobe Acute mountain sickness and high-altitude cerebral edema ...
Blue rubber bleb nevus Glomus tumor POEMS syndrome Burning feet syndrome (Gopalan's) Trench foot Causalgia ... often seen in Raeder's syndrome) Harlequin syndrome Emotional hyperhidrosis A variety of cancers have been associated with the ... Other possible side-effects include Horner's Syndrome (about 1%), gustatory sweating (less than 25%) and excessive dryness of ... Riley-Day syndrome) Congenital autonomic dysfunction with universal pain loss Exposure to cold, notably associated with cold- ...
... poems syndrome MeSH C15.378.147.780.925 - waldenstrom macroglobulinemia MeSH C15.378.147.880 - protein c deficiency MeSH ... chediak-higashi syndrome MeSH C15.378.553.774.535 - granulomatous disease, chronic MeSH C15.378.553.774.600 - job's syndrome ... sezary syndrome MeSH C15.604.515.880 - tumor lysis syndrome MeSH C15.604.515.925 - waldenstrom macroglobulinemia MeSH C15.604. ... waterhouse-friderichsen syndrome MeSH C15.378.463.960 - wiskott-aldrich syndrome MeSH C15.378.553.231 - eosinophilia MeSH ...
The fictional poem "San Clemente Syndrome" - also the title of the third part - in Call Me By Your Name is named after the ...
... a poem by Friedrich Schiller Resignation syndrome, a dissociative syndrome that induces a catatonic state General George ...
The titular character in the Simon and Garfunkel song "Richard Cory" (based on the Edward Arlington Robinson poem of the same ... Tahiti Syndrome, while not officially recognized by psychologists as a mental condition, is a term used by some to refer to a ... In the episode 'Time On Our Hands' of the TV series 'Only Fools and Horses', Del Boy exhibits Paradise Syndrome after finally ... The phrase may also refer to an episode of Star Trek, "The Paradise Syndrome", and in this instance, deals with being ...
The album featured "Scorn Not His Simplicity", a song that Coulter had composed about his own son, who had Down syndrome, as ... well as a poem penned by Luke Kelly entitled "For What Died The Sons Of Róisín?". The album was released on CD by Chyme Records ...
... by Daniel Rancour-Laferriere suggests that there is an underlying concern with couvade syndrome or male birthing in the poem. ... The Pushkin critic A. D. P. Briggs praises the poem "as the best in the Russian language, and even the best poem written ... Other literary references to the poem include Anna Akmatova's "Poem Without a Hero", which mentions the Bronze Horseman "first ... and a poem mocks the Falconet statue as looking as though he is about to jump off a precipice. Pushkin's poem can be read in ...
... poems/chernobyl_poems.html) Pripyat syndrome: the film-story - Poltava, 2009, 196 pages - ISBN 978-966-18-2031-8 (in Russian ... "The Chernobyl Poems of Lyubov Sirota". So her poems have sounded in the National radio of America (program Terra Infirma), have ... "Poems by a Pripyat" - pages 184 - 188) - ISBN 0-7377-4555-X ; ISBN 978-0-7377-4555-9 Paul Brians "The Chernobyl Poems of Lyubov ... "Pripyat syndrome" The Pripyat Syndrome by Lyubov Sirota; e-Book, Language: English Lyubov Sirota's channel on YouTube "Our ...
... syndrome Pitt-Hopkins syndrome Plica syndrome Plummer-Vinson syndrome POEMS syndrome Poland syndrome Polar T3 syndrome Polio- ... syndrome Wende-Bauckus syndrome Werner syndrome Wernicke-Korsakoff syndrome West syndrome Westerhof syndrome Wet lung syndrome ... syndrome Shone's syndrome Short anagen syndrome Short bowel syndrome short limb syndrome Short man syndrome Short QT syndrome ... syndrome Radial tunnel syndrome Rage syndrome Raghib syndrome Raine syndrome Ramos-Arroyo syndrome Ramsay Hunt syndrome type 1 ...
The Chernobyl Poems of Lyubov Sirota by the professor of Washington University Paul Brians Lyubov Sirota's novel "The Pripyat ... Syndrome"; Language: English, Publisher: Independently published (February 18, 2021), Paperback: 202 pages, ISBN 979-8710522875 ...
POEMS syndrome (also termed osteosclerotic myeloma, Crow-Fukase syndrome, Takatsuki disease, or PEP syndrome) is a rare ... Neuropathy can occur in CD patients with or without POEMS syndrome. CD and POEMS tend to overlap, with roughly 15-24% of POEMS ... affected by POEMS syndrome. The diagnosis of POEMS syndrome is based on meeting its two mandatory criteria, meeting at least ... Some features have been observed in patients with POEMS syndrome but are not yet certain to form part of the syndrome itself. ...
POEMS) syndrome is a rare multisystemic disease that occurs in the setting of a plasma cell dyscrasia. The pathophysiologic ... POEMS syndrome was first described by Crow in 1956 and then by Fukase in 1968. The syndrome was termed Crow-Fukase syndrome (by ... 16, 17, 18, 19] The neurologic sequelae of POEMS syndrome cause approximately 50% of the patients with POEMS syndrome to become ... The median survival period for patients with POEMS syndrome is 8 years. The natural course of POEMS syndrome is chronic, with a ...
Polyneuropathy organomegaly endocrinopathy monoclonal gammopathy and skin changes syndrome. Authoritative facts from DermNet ... What causes POEMS syndrome?. The cause of POEMS syndrome is not well understood. It is associated with a chronic overproduction ... Who gets POEMS syndrome?. POEMS syndrome is rare, with only a few hundred cases described in the medical literature. However, ... POEMS syndrome is not usually associated with mucous membrane involvement.. Other symptoms and signs. POEMS syndrome may also ...
Clinical trial for POEMS Syndrome , Treatment of POEMS Syndrome With Daratumumab ... Not sure for Patients must have POEMS syndrome and meet the diagnostic criteria for POEMS syndrome as described in Appendix I ... Yes for Patients must have POEMS syndrome and meet the diagnostic criteria for POEMS syndrome as described in Appendix I ... No for Patients must have POEMS syndrome and meet the diagnostic criteria for POEMS syndrome as described in Appendix I ...
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This poem was submitted by Spencer Ginyard, a young man who has Prader-Willi syndrome. Spencer recently graduated from Cal ... Grandma Lee: A Poem by Spencer Ginyard. July 23, 2020. June 5, 2023. PWSA , USA ... Mission: To enhance the quality of life of and empower those affected by Prader-Willi syndrome.. Vision: A world where those ... She obtained her PhD from Capella University in Education focusing her research on Prader-Willi Syndrome. Dr. McTighe is also a ...
In fact, Gabriels poem also reminded us that there is much joy and laughter to be had from having a sibling with Down syndrome ... For World Down Syndrome Day here is Gabriel’s poem for his sister Ruth â ¤ï¸ #wdsd2023pic.twitter.com/cctu8ESQfD ... Big brothers poem to sister with Down syndrome melts hearts. @media print{.css-my9yfq{display:none;}}. .css-aex76m{margin- ... Although siblings often bicker and drive each other nuts, this particular poem was one of love and understanding - a poem that ...
POEMS syndrome is potentially fatal and adversely affects quality of life. Oedema is common with many patients affected by ... Polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes (POEMS) syndrome is a rare paraneoplastic disorder ... Longitudinal bioimpedance assessments to evaluate hydration in POEMS syndrome. BMJ Supportive and Palliative Care, 2016 (6). pp ... use of sequential BIVA assessments to evaluate the response to diuretic therapy in a woman aged 52 years with POEMS syndrome. ...
POEMS Syndrome - Learn about the causes, symptoms, diagnosis & treatment from the MSD Manuals - Medical Consumer Version. ... POEMS Syndrome (Crow-Fukase Syndrome; Takatsuki Disease; PEP Syndrome). By Jennifer M. Barker , MD, Childrens Hospital ... Diagnosis of POEMS Syndrome POEMS syndrome is diagnosed based on the presence of certain symptoms and findings during a ... See also Polyglandular Deficiency Syndromes Polyglandular Deficiency Syndromes Polyglandular deficiency syndromes are ...
What is POEMS syndrome?. This is an autoimmune condition characterised by:. Polyneuropathy - dysfunctioning peripheral motor ...
PEP syndrome Overview. Historical Perspective. Pathophysiology. Causes. Differentiating POEMS syndrome from other Diseases. ... Retrieved from "https://www.wikidoc.org/index.php?title=POEMS_syndrome&oldid=1551094" ... Synonyms and keywords: Crow-Fukase syndrome; Takatsuki disease; ... American Roentgen Ray Society Images of POEMS syndrome All ...
POEMS Syndrome POEMS SyndromeThe rare blood disorder named for its symptoms.By Jenny Ewen, BA, NREMTEditor-In-ChiefPOEMS ... NORD, Rare Diseases, "POEMS Syndrome" https://rarediseases.org/rare-diseases/poems-syndrome/ ... Cleveland Clinic, Rare Health Diseases, "POEMS Syndrome" https://my.clevelandclinic.org/health/diseases/17985-poems-syndrome ... Mayo Clinic, Disease and Conditions, "POEMS Syndrome" https://www.mayoclinic.org/diseases-conditions/poems-syndrome/symptoms- ...
... J Minarik *, 1, V Scudla1, J Bacovsky1, T Pika1 , P Petrova2 ... POEMS syndrome is a clinical unit with a very heterogenous clinical behavior. Its diagnostics as well as monitoring are not ... We present three case reports of patients with POEMS syndrome with different clinical manifestation and course of the disease. ... for the diagnostics but also as a potential marker of therapeutic response and for monitoring of the course of POEMS syndrome. ...
Polyneuropathy improvement following autologous stem cell transplantation for POEMS syndrome. Chafic Karam, Christopher J. ... Dive into the research topics of Polyneuropathy improvement following autologous stem cell transplantation for POEMS syndrome ...
POEMS syndrome is a paraneoplastic syndrome whose acronym stands for less than half of the defining features of the disease, ...
Soft Machine (Truman Syndrome) and Soft Machine (in Isolation). Two poems by Thomas Irvine. by admin. May 1, 2020. Leave a ... Soft Machine (Truman Syndrome). Spot people from where theyre not; window of an airplane,. dont believe theyre still there ... CommentSoft Machine (Truman Syndrome) and Soft Machine (in Isolation). Two poems by Thomas Irvinepoetry ...
Poem - Skein Syndrome (ViciSolum) - Progressive. Purgatory - Omega Void Tribvnal (War Anthem) - Death metal. Rapheumetas Well ...
IntroductionPOEMS syndrome is a rare systemic disorder characterized by various symptoms, including polyneuropathy, ... PC of bone marrow samples in patients with POEMS syndrome by MFC and validated gating strategies of PC in POEMS syndrome. ... Detection of Clonal Plasma Cells in POEMS Syndrome Using Multiparameter Flow Cytometry Arata Ishii, Arata Ishii ... Aberrant immunophenotype of clonal PC in POEMS syndrome was similar to MM for CD19 and CD56 expression; however, CD45 and CD38 ...
POEMS syndrome. *MGUS. $13,000. Fully subscribed and closed to enrollment. Myeloproliferative Neoplasms (MPN). *Myelofibrosis ( ...
The clinical study of POEMS syndrome in China.. Zhang B, Song X, Liang B, Hou Q, Pu S, Ying J, Gao C. ... OBJECTIVE: POEMS syndrome is a unique clinical entity. It was described by the presence of several typical characteristics as ... Zhang B, Song X, Liang B, Hou Q, Pu S, Ying J, Gao C. The clinical study of POEMS syndrome in China. Neuro Endocrinol Lett. ... PATIENTS AND METHODS: Retrospective evaluation of Chinese patients with POEMS syndrome was carried out to reveal clinical ...
POEMS syndrome, and Waldenstroms macroglobulinemia. The research interests in my lab are on the development of new approaches ...
POEMS Syndrome - A Case for More Aggressive Treatment. Rahul Rathakrishnan, Te-Chih Liu, Yee-Cheun Chan, Benjamin KC Ong ... POEMS syndrome is a rare, multisystem disorder originally characterised by the presence of polyneuropathy, organomegaly, ... Clinical Report: A Case of Williams Syndrome and Klinefelter Syndrome. Le Ye Lee, Swee Chye Quek, Samuel S Chong, Arnold SC Tan ... Cushings syndrome is usually easy to recognise clinically. Determining the cause of non-iatrogenic Cushings syndrome is, on ...
Accordingly, POEMS syndrome is also called osteosclerotic myeloma (41-44). Although the diagnosis of POEMS syndrome is complex ... POEMS syndrome as seen on 18F-FDG PET/CT. From left to right are shown sagittal CT, emission PET, fused PET/CT, and axial CT ( ... Endocrinopathy in POEMS syndrome: the Mayo Clinic experience. Mayo Clin Proc. 2007;82:836-842. ... POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, presence of M protein, and skin changes) is a rare, poorly ...
POEMS Syndrome * Primary Systemic Amyloidosis * Waldenstrom Macroglobulinemia (WM) Show All Expertise Programs and Centers. ...
Poems Syndrome * Polycythemia * Porphyria * Post Thrombotic Syndrome (PTS) * Primary Myelofibrosis * Primary Systemic ...
POEMS Syndrome. - Non-secretory multiple myeloma. - Active infection requiring antibiotics. - Clinically significant hepatic ...
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POEMS syndrome poikiloderma with neutropenia Pointer Syndrome Poland syndrome Polycystic Lipomembranous Osteodysplasia with ... urofacial syndrome + A syndrome that is characterized by inverted facial expressions in association with a severe and early- ... Cerebellar Vermis Aplasia with Associated Features suggesting Smith-Lemli-Opitz Syndrome and Meckel Syndrome ... urofacial syndrome (DOID:0050816). Annotations: Rat: (2) Mouse: (2) Human: (2) Chinchilla: (2) Bonobo: (2) Dog: (2) Squirrel: ( ...
POEMS syndrome (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal plasmaproliferative disorder, Skin changes); or ... Total bilirubin < 2.0 mg/dL (or < 3.0 mg/dL for subjects with documented Gilberts syndrome); ...
  • The name POEMS is an acronym for some of the disease's major signs and symptoms (polyneuropathy, organomegaly, endocrinopathy, myeloma protein, and skin changes), as is PEP (polyneuropathy, endocrinopathy, plasma cell dyscrasia). (wikipedia.org)
  • Polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome is a rare multisystemic disease that occurs in the setting of a plasma cell dyscrasia. (medscape.com)
  • The polyneuropathy associated with POEMS syndrome is a bilateral symmetric disturbance. (medscape.com)
  • A case of atypical POEMS syndrome without polyneuropathy. (medscape.com)
  • Li Y, Valent J, Soltanzadeh P, Thakore N, Katirji B. Diagnostic challenges in POEMS syndrome presenting with polyneuropathy: A case series. (medscape.com)
  • POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, M-protein, Skin changes) syndrome is a rare hematological disease associated with overproduction of pro-inflammatory cytokines. (elsevierpure.com)
  • Under the current nomenclature and diagnostic criteria for POEMS syndrome, the presence of characteristic polyneuropathy is required for diagnosis. (elsevierpure.com)
  • 2. Update on the Diagnosis and Treatment of POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Gammopathy, and Skin Changes) Syndrome: A Review. (nih.gov)
  • 3. A prospective phase II study of low dose lenalidomide plus dexamethasone in patients with newly diagnosed polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome. (nih.gov)
  • 4. [POEMS syndrome: monoclonal plasma cell disorder with polyneuropathy]. (nih.gov)
  • 7. Skin Responses in Newly Diagnosed Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Gammopathy, and Skin Changes (POEMS) Syndrome After Therapy With Low-Dose Lenalidomide Plus Dexamethasone. (nih.gov)
  • 9. POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes) treated with autologous hematopoietic stem cell transplantation: a case report and literature review. (nih.gov)
  • 15. Living with Polyneuropathy Organomegaly Endocrinopathy Monoclonal gammopathy Skin changes (POEMS) syndrome: a case study of healthcare experiences and quality of life. (nih.gov)
  • Inflammatory mechanisms appear to play a significant role in some types of pulmonary hypertension (PH), including monocrotaline-induced PH in rats and pulmonary arterial hypertension of various origins in humans, such as connective tissue diseases (scleroderma, systemic lupus erythematosus, mixed connective disease), human immunodeficiency virus infection, or plasma cell dyscrasia with polyneuropathy, organomegaly, endocrinopathy, monoclonal (M) protein and skin changes (POEMS) syndrome. (ersjournals.com)
  • The acronym "POEMS" stands for the most common features of the disorder: polyneuropathy (nerve damage), organomegaly (enlarged organs), endocrinopathy (hormonal imbalances), monoclonal gammopathy (abnormal proteins in the blood), and skin changes. (dailycatchers.com)
  • Elevated levels of VEGF is linked to POEMS syndrome (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy, Skin changes) also known as Crow-Fukase syndrome which affects multiple organs in the body. (thermofisher.com)
  • The syndrome was termed Crow-Fukase syndrome (by which it is known in Japan) by Nakanishi in a study of 102 cases in Japan. (medscape.com)
  • The proportions of POEMS clones in plasma cells were markedly smaller than in patients with multiple myeloma (MM) and patients with monoclonal gammopathy of undetermined significance (MGUS). (jci.org)
  • I have not heard of POEMS Syndrome, especially under the Multiple Myeloma umbrella. (cancer.org)
  • American singer, Billie Eilish, was diagnosed with Tourette Syndrome when she was 11 years old. (outlookindia.com)
  • Tourette Syndrome is a nervous system disorder characterised by recurring involuntary tics, which are repetitive, involuntary bodily motions such as twitches and verbal outbursts. (outlookindia.com)
  • Tourette syndrome symptoms, such as uncontrolled tics and spontaneous verbal outbursts, intensify at times of excitement, stress, or worry. (outlookindia.com)
  • According to the American Brain Foundation, around 200,000 persons in the United States have severe Tourette syndrome symptoms. (outlookindia.com)
  • Eilish underlined throughout the chat show that she is not alone in having Tourette syndrome. (outlookindia.com)
  • However, the findings of a retrospective analysis of 629 patients using these criteria suggest that this approach may be inadequate for excluding other disease processes that may account for symptoms and that atypical presentations of POEMS may be misdiagnosed. (medscape.com)
  • Atypical central retinal artery occlusion as the first presentation of POEMS syndrome: a case report. (medscape.com)
  • 1. Clinical characteristics and the long-term outcome of patients with atypical POEMS syndrome variant with undetectable monoclonal gammopathy. (nih.gov)
  • The diagnosis of POEMS syndrome is based on meeting its two mandatory criteria, meeting at least one of its 3 other major criteria, and meeting at least one of its 6 minor criteria. (wikipedia.org)
  • mean age at diagnosis 54.45 years) with POEMS syndrome. (bmj.com)
  • According to the The International Myeloma Working Group, the diagnosis of POEMS syndrome may be established if both mandatory criteria, one major and one minor criteria are fulfilled. (wikidoc.org)
  • In summary, our study demonstrate the POEMS syndrome diagnostic criteria proposed by Dispenzieri et al is also more high applicability in the Chinese population.At the time of diagnosis, we should not pay attention on the typical characteristics of the disease, but also on the changes in thyroid, liver, kidney function and lipid metabolism. (nel.edu)
  • 12. [POEMS syndrome: Diagnosis, stratification, treatments]. (nih.gov)
  • 20. POEMS Syndrome: 2019 Update on diagnosis, risk-stratification, and management. (nih.gov)
  • Glomeruloid Hemangioma as a Marker for the Early Diagnosis of POEMS Syndrome. (dermnetnz.org)
  • POEMS syndrome (also termed osteosclerotic myeloma, Crow-Fukase syndrome, Takatsuki disease, or PEP syndrome) is a rare paraneoplastic syndrome caused by a clone of aberrant plasma cells. (wikipedia.org)
  • Although many plasma cell disorders have been reported in patients with POEMS syndrome, most patients are seen with osteosclerotic myeloma or monoclonal gammopathy of unknown significance. (medscape.com)
  • Many of the signs and symptoms in POEMS syndrome are due at least in part to the release of an aberrant immunoglobulin, i.e. a myeloma protein, as well as certain cytokines by the malignant plasma cells. (wikipedia.org)
  • It is suggested that various other cytokines produced by the clonal plasma cells, perhaps working in concert with each other as well as with VEGF and the myeloma proteins, mediate many of the features of POEMS syndrome. (wikipedia.org)
  • For example, VEGF, given its ability to stimulate blood vessel formation, would seem likely to be the major contributor to the pathologic hyper-vascularization changes seem in many tissues, such as lymph nodes, affected by POEMS syndrome. (wikipedia.org)
  • Watanabe O, Arimura K, Kitajima I, Osame M, Maruyama I. Greatly raised vascular endothelial growth factor (VEGF) in POEMS syndrome. (medscape.com)
  • POEMS syndrome is a rare monoclonal plasma cell disorder, with unique symptoms distinct from those of other plasma cell neoplasms, including high serum VEGF levels. (jci.org)
  • VEGF mRNA was not upregulated in POEMS clones, directly indicating that VEGF is not produced by POEMS clones. (jci.org)
  • 13. Correlation of changes in serum level of VEGF and peripapillary retinal thickness in patients with POEMS syndrome. (nih.gov)
  • Polyglandular Deficiency Syndromes Polyglandular deficiency syndromes are hereditary disorders in which several endocrine (hormone-producing) glands malfunction. (msdmanuals.com)
  • A remarkable variety of endocrinologic disorders may cause virilization syndromes. (annals.edu.sg)
  • Elevated levels of this protein are linked to POEMS syndrome, also known as Crow-Fukase syndrome. (prospecbio.com)
  • Ofran Y, Yishay O, Elinav E, Eran E. POEMS syndrome: failure of newly suggested diagnostic criteria to anticipate the development of the syndrome. (medscape.com)
  • If further similar cases are reported in the future, reconsideration of the nomenclature and/or diagnostic criteria for POEMS syndrome may be required. (elsevierpure.com)
  • Signs and symptoms of a cancer causing a paraneoplastic syndrome result from the release of humoral factors such as hormones, cytokines, or immunoglobulins by the syndrome's neoplastic cells and/or the response of the immune system to the neoplasm. (wikipedia.org)
  • Paraneoplastic Syndromes Paraneoplastic (associated with cancer-see also Overview of Cancer) syndromes occur when a cancer causes unusual symptoms due to substances that circulate in the bloodstream. (msdmanuals.com)
  • 5. Skin manifestations and vascular endothelial growth factor levels in POEMS syndrome: impact of autologous hematopoietic stem cell transplantation. (nih.gov)
  • 6. Vascular endothelial growth factor as a predictive marker for POEMS syndrome treatment response: retrospective cohort study. (nih.gov)
  • Some features have been observed in patients with POEMS syndrome but are not yet certain to form part of the syndrome itself. (wikipedia.org)
  • Allam JS, Kennedy CC, Aksamit TR, Dispenzieri A. Pulmonary manifestations in patients with POEMS syndrome: a retrospective review of 137 patients. (medscape.com)
  • Retrospective evaluation of Chinese patients with POEMS syndrome was carried out to reveal clinical features and compare with foreign series reported previously. (nel.edu)
  • POEMS syndrome is seen in the setting of a plasma cell dyscrasia. (medscape.com)
  • POEMS syndrome is a rare plasma cell dyscrasia. (nih.gov)
  • The type of plasma cell disorder has not been shown to be correlated with the constellation of symptoms noted in patients with POEMS syndrome. (medscape.com)
  • POEMS syndrome is a rare disorder in which more than one endocrine gland is dysfunctional. (msdmanuals.com)
  • 19. POEMS syndrome: A multisystem clonal disorder. (nih.gov)
  • POEMS SyndromeThe rare blood disorder named for its symptoms.By Jenny Ewen, BA, NREMTEditor-In-ChiefPOEMS syndrome is a rare blood disorder suspected to affect up to 5000 people in the USA, primarily men who are in later adulthood (around age 50). (alliedmedtraining.com)
  • POEMS syndrome is a rare disorder in which there is an overgrowth of abnormal plasma cells, along with various other symptoms such as nerve damage, skin changes, and organ dysfunction. (dailycatchers.com)
  • According to a researcher called Treffert, "Roughly half of all the people with the syndrome have autistic disorder whereas the remaining half face development disability referred to as mental retardation or brain injury. (bestwritingservice.com)
  • Hi Roger, I just completed radiation for single plasmacytoma POEMS Syndrome. (cancer.org)
  • Multiple endocrinopathies have been associated with POEMS syndrome, and most patients have more than 1 endocrine abnormality. (medscape.com)
  • EE+ POEM Archive , John Wiley & Sons, 2019. (unboundmedicine.com)
  • 2019. https://evidence.unboundmedicine.com/evidence/view/infoPOEMs/426614/all/Fesoterodine_effective_for_treating_overactive_bladder_syndrome. (unboundmedicine.com)
  • [ 5 ] mental retardation and retinal disease are among the syndromes that also are associated with acquired partial lipodystrophy. (medscape.com)
  • The signs and symptoms of POEMS syndrome are highly variable. (wikipedia.org)
  • 17. Successful treatment of a patient with POEMS syndrome by tandem high-dose chemotherapy with autologous CD34+ purged stem cell rescue. (nih.gov)
  • Subacute, distal, symmetrical sensorimotor neuropathy with allodynia and hyperpathia is the most frequent presentation of POEMS syndrome. (wikipedia.org)
  • Angiogenetic factors and biochemical markers of bone metabolism in POEMS syndrome treated with high-dose therapy and autologous stem cell support. (medscape.com)
  • The standard therapy for patients with POEMS syndrome is high-dose chemotherapy followed by autologous stem cell transplantation. (nii.ac.jp)
  • On iliac crest biopsies, patients with POEMS syndrome often have few monoclonal plasma cells. (wikipedia.org)
  • however, most authors agree that patients with POEMS syndrome should have 3 or more of the 5 features. (medscape.com)
  • Approximately 15% of patients with POEMS syndrome have concomitant evidence of Castleman disease, and both may be associated with glomeruloid hemangioma. (medscape.com)
  • Electrophysiological features of patients with POEMS syndrome. (medscape.com)
  • Kourelis TV, Dispenzieri A. Validation of a prognostic score for patients with POEMS syndrome: a mayo clinic cohort. (medscape.com)
  • Ischemic stroke in patients with POEMS syndrome. (medscape.com)
  • In conclusion, POEMS patients present a high prevalence of meningeal involvement. (bmj.com)
  • We analyzed the mutational features of purified bone marrow plasma cells from 42 patients newly diagnosed with POEMS syndrome using a two-step strategy. (nih.gov)
  • Herein, we performed single-cell RNA-Seq of BM plasma cells from patients with POEMS syndrome and identified POEMS clones that had Ig λ light chain (IGL) sequences (IGLV1-36, -40, -44, and -47) with amino acid changes specific to POEMS syndrome. (jci.org)
  • Few people reported characteristics of Chinese POEMS patients. (nel.edu)
  • The net metabolic outcome in patients of diabetes with a syndrome or a condition (e.g., a with secondary diabetes thus depends on the direct or number of genetic syndromes). (nih.gov)
  • 10. Autologous cytokine-induced killer (CIK) cell immunotherapy combined with cyclophosphamide in five patients with POEMS syndrome. (nih.gov)
  • Response to: 'Correspondence on 'Association between treatment with colchicine and improved survival in a single-centre cohort of adult hospitalised patients with COVID-19 pneumonia and acute respiratory distress syndrome'' by Kawada. (nih.gov)
  • [ 4 ] This may be related to the fact that in this syndrome, patients have limited fat loss. (medscape.com)
  • In addition to the signs and symptoms indicated by the POEMS acronym, the PEST acronym is used to describe some of the other signs and symptoms of the disease. (wikipedia.org)
  • POEMS syndrome is often complicated by pulmonary hypertension. (nii.ac.jp)
  • Herein, we report the case of a 54-year-old woman with POEMS syndrome accompanied by pulmonary hypertension. (nii.ac.jp)
  • Thus, Ld can be considered as safe and effective for pulmonary hypertension with POEMS syndrome. (nii.ac.jp)
  • Treatment options for POEMS syndrome may include radiation therapy, chemotherapy, and stem cell transplant. (dailycatchers.com)
  • The more common features of the disease are summarized in the acronym POEMS: Papilledema (swelling of the optic disc) often but not always due to increased intracranial pressure) is the most common ocular sign of POEMS syndrome, occurring in ≥29% of cases. (wikipedia.org)
  • 11. [POEMS syndrome: advances in molecular pathophysiology and treatment]. (nih.gov)
  • Temporal dispersion in demyelination of POEMS syndrome and Castleman disease. (medscape.com)
  • These results reveal unique features of POEMS clones and enhance our understanding of the pathogenesis of POEMS syndrome. (jci.org)
  • POEMS syndrome is probably caused by antibodies (immunoglobulins) that circulate in the blood and damage organs, particularly endocrine glands. (msdmanuals.com)
  • Severe to extreme insulin resistance syndromes b. (nih.gov)
  • Neuropathic pain correlates with myelinated fiber loss and cytokine profile in POEMS syndrome. (medscape.com)
  • Long-term evaluation of physical improvement and survival of autologous stem cell transplantation in POEMS syndrome. (medscape.com)
  • Glucocorticoid excess (Cushing's syndrome) dysplasia, dystrophic nails) c. (nih.gov)
  • [ 5 ] serum electrophoresis demonstrated an M-band with isolated IgA heavy chain but no abnormal light chain, which could suggest abnormal secretion of monoclonal protein or the rare possibility of coincidental heavy-chain disease in association with POEMS syndrome. (medscape.com)
  • Mitochondrial tRNA gene mutation syndromes f. (nih.gov)
  • The News We've Been Waiting for: "Gene Therapy Program for Rett Syndrome will be advanced by biotech company. (magnoliashope.com)
  • Clinical Significance of Anti-Ku Autoantibodies -A Serologic Marker of Overlap Syndrome? (go.jp)
  • Infantile spasms, newly classified as infantile epileptic spasm syndrome (IESS), occur in children under 2 years of age and present as an occur as brief, symmetrical, contractions of the musculature of the neck, trunk, and extremities. (qxmd.com)
  • When infantile spasms occur with a concomitant hypsarrhythmia on electroencephalogram (EEG) and developmental regression, it is known as West Syndrome. (qxmd.com)
  • Genetic and transcriptional landscape of plasma cells in POEMS syndrome. (cdc.gov)
  • When their daughter was diagnosed with rare neurological disease, Rett Syndrome, they promised her they would do everything they could to find a cure and help her live the best life she could. (magnoliashope.com)
  • 7. Alström syndrome (obesity, retinitis pigmentosa, deafness) e. (nih.gov)
  • POEMS syndrome is often associated with an IgA or IgG lambda limited plasma cell dysfunction. (wikipedia.org)
  • POEMS syndrome typically begins in middle age - the average age at onset is 50 - and affects up to twice as many men as women. (wikipedia.org)
  • Acquired partial lipodystrophy (APL) also known as Barraquer-Simons syndrome or cephalothoracic lipodystrophy, is one of the rare forms of lipodystrophy. (medscape.com)
  • 16. Neurologic improvement after peripheral blood stem cell transplantation in POEMS syndrome. (nih.gov)
  • 2. Type B syndrome--associated with autoantibodies to d. (nih.gov)