Prostatitis
Pelvic Pain
Prostate
Chronic Disease
Prostatein
Prostatic Hyperplasia
Phellodendron
Gardenia
Urethritis
Polygonum
Epididymitis
Pyelonephritis
Cellular Phone
Prevalence of corynebacterial 16S rRNA sequences in patients with bacterial and "nonbacterial" prostatitis. (1/271)
The etiology of chronic prostatitis syndromes in men is controversial, particularly when positive cultures for established uropathogens are lacking. Although identification of bacteria in prostatic fluid has relied on cultivation and microscopy, most microorganisms in the environment, including some human pathogens, are resistant to cultivation. We report here on an rRNA-based molecular phylogenetic approach to the identification of bacteria in prostate fluid from prostatitis patients. Positive bacterial signals were seen for 65% of patients with chronic prostatitis overall. Seven of 11 patients with bacterial signals but none of 6 patients without bacterial signals were cured with antibiotic-based therapy. Results indicate the occurrence in the prostate fluid of a wide spectrum of bacterial species representing several genera. Most rRNA genes were closely related to those of species belonging to the genera Corynebacterium, Staphylococcus, Peptostreptococcus, Streptococcus, and Escherichia. Unexpectedly, a wide diversity of Corynebacterium species was found in high proportion compared to the proportions of other bacterial species found. A subset of these 16S rRNA sequences represent those of undescribed species on the basis of their positions in phylogenetic trees. These uncharacterized organisms were not detected in control samples, suggesting that the organisms have a role in the disease or are the consequence of the disease. These studies show that microorganisms associated with prostatitis generally occur as complex microbial communities that differ between patients. The results also indicate that microbial communities distinct from those associated with prostatitis may occur at low levels in normal prostatic fluid. (+info)Virulence characteristics of Escherichia coli in acute bacterial prostatitis. (2/271)
To assess the urovirulence characteristics of Escherichia coli strains causing acute prostatitis, urinary isolates from men with acute prostatitis (n=107) and from women with acute uncomplicated pyelonephritis (n=76) were examined for the prevalence of sfa, foc, and 3 papG allele genotypes and phenotypes and for the production of alpha-hemolysin and cytotoxic necrotizing factor 1. The papG allele III and foc gene were found more frequently and the papG allele II less frequently among prostatitis than from pyelonephritis isolates. A higher proportion of hly+ cnf1+ genotype in prostatitis strains (64% vs. 36%) was particularly striking. Both prostatitis and pyelonephritis strains expressed virulence factors similarly except for a higher proportion of nonhemolytic prostatitis isolates. Although the pathogenetic mechanisms of urinary tract infections in men and women may differ, virulence factors such as adhesins and cytotoxins may have important roles in the pathogenesis of acute prostatitis. (+info)The reactive oxygen species-total antioxidant capacity score is a new measure of oxidative stress to predict male infertility. (3/271)
The imbalance between reactive oxygen species (ROS) production and total antioxidant capacity (TAC) in seminal fluid indicates oxidative stress and is correlated with male infertility. A composite ROS-TAC score may be more strongly correlated with infertility than ROS or TAC alone. We measured ROS, TAC, and ROS-TAC scores in semen from 127 patients and 24 healthy controls. Of the patients, 56 had varicocele, eight had varicocele with prostatitis, 35 had vasectomy reversals, and 28 had idiopathic infertility. ROS levels were higher among infertile men, especially those with varicocele with prostatitis (mean +/- SE, 3.25 +/- 0.89) and vasectomy reversals (2.65 +/- 1.01). All infertile groups had significantly lower ROS-TAC scores than control. ROS-TAC score identified 80% of patients and was significantly better than ROS at identifying varicocele and idiopathic infertility. The 13 patients whose partners later achieved pregnancies had a mean ROS-TAC score of 47.7 +/- 13.2, similar to controls but significantly higher than the 39 patients who remained infertile (35.8 +/- 15.0; P < 0.01). ROS-TAC score is a novel measure of oxidative stress and is superior to ROS or TAC alone in discriminating between fertile and infertile men. Infertile men with male factor or idiopathic diagnoses had significantly lower ROS-TAC scores than controls, and men with male factor diagnoses that eventually were able to initiate a successful pregnancy had significantly higher ROS-TAC scores than those who failed. (+info)Maternal exposure to atrazine during lactation suppresses suckling-induced prolactin release and results in prostatitis in the adult offspring. (4/271)
The availability of prolactin (PRL) to the neonatal brain is known to affect the development of the tuberoinfundibular (TIDA) neurons and, as a consequence, lead to alterations in subsequent PRL regulation. Without early lactational exposure to PRL (derived from the dam's milk), TIDA neuronal growth is impaired and elevated PRL levels are present in the prepubertal male. These observations, combined with the finding that alterations in PRL secretion (i.e., hyperprolactinemia) in the adult male rat have been implicated in the development of prostatitis, led us to hypothesize that early lactational exposure to agents that suppress suckling-induced PRL release would lead to a disruption in TIDA development, altered PRL regulation, and subsequent prostatitis in the male offspring. To test this hypothesis, suckling-induced PRL release was measured in Wistar dams treated twice daily with the herbicide atrazine (ATR, by gavage, on PND 1-4 at 0, 6.25, 12.5, 25, and 50 mg/kg body weight), or twice daily with the dopamine receptor agonist bromocriptine (BROM, sc, at 0.052, 0.104, 0.208, and 0.417 mg/kg); BROM is known to suppress PRL release. Similarly, atrazine has also been reported to suppress PRL in adult females. Serum PRL was measured on PND 3 using a serial sampling technique and indwelling cardiac catheters. A significant rise in serum PRL release was noted in all control females within 10 min of the initiation of suckling. Fifty-mg/kg ATR inhibited suckling-induced PRL release in all females, whereas 25 and 12.5 mg/kg ATR inhibited this measure in some dams and had no discernible effect in others. The 6.25 mg/kg dose of ATR was without effect. BROM, used here as a positive control, also inhibited suckling-induced PRL release at doses of 0.104 to 0.417 mg/kg, with no effect at 0.052 mg/kg. To examine the effect of postnatal ATR and BROM on the incidence and severity of inflammation (INF) of the lateral prostate of the offspring, adult males were examined at 90 and 120 days. While no effect was noted at 90 days of age, at 120 days, both the incidence and severity of prostate inflammation was increased in those offspring of ATR-treated dams (25 and 50 mg/kg). The 12.5 mg/kg ATR and the two highest doses of BROM increased the incidence, but not the severity, of prostatitis. Combined treatment of ovine prolactin (oPRL) and 25 or 50 mg/kg ATR on PND 1-4 reduced the incidence of inflammation observed at 120 days, indicating that this increase in INF, seen after ATR alone, resulted from the suppression of PRL in the dam. To determine whether or not there is a critical period for these effects, dams were dosed with 25 and 50 mg/kg on PND 6-9 and PND 11-14. Inflammation was increased in those offspring from dams treated on PND 6-9, but this increase was not significant. Dosing on PND 11-14 was without effect. These data demonstrate that ATR suppresses suckling-induced PRL release and that this suppression results in lateral prostate inflammation in the offspring. The critical period for this effect is PND 1-9. (+info)Prepubertal exposure to compounds that increase prolactin secretion in the male rat: effects on the adult prostate. (5/271)
To test the hypothesis that a transient increase in prolactin (PRL) secretion prior to puberty can result in an alteration of the adult prostate, male rats were exposed from postnatal Days (PND) 22 to 32 to compounds that increase PRL secretion. These compounds included pimozide (a dopamine antagonist), estradiol-17beta, and bisphenol A (a monomer of polycarbonate plastics reported to have weak estrogenic activity). During dosing, pimozide (PIM), bisphenol A (BPA), and estradiol-17beta (E(2)) stimulated an increased secretion of PRL. At 120 days of age, the lateral prostate weight was increased in the PIM and BPA groups as compared to the vehicle-injected controls. Examination of the prostates revealed inflammation in the lateral lobes of all treated groups. Results of a myeloperoxidase assay, a quantitative assay to assess acute inflammation, indicated an increase in the percentage of males with neutrophil infiltrate in the lateral prostates of the PIM and E(2) treatment groups compared to their respective controls. The histological evaluations of these tissues confirmed an increase in luminal polymorphonuclear cells and interstitial mononuclear cells of the lateral prostates in all treatment groups. Administration of the dopamine agonist, bromocriptine, to the estradiol-implanted males from PND 22 to 32 reversed the induction of lateral prostate inflammation by estradiol, suggesting that PRL was necessary for the inflammatory effect. This study demonstrates that prepubertal exposures to compounds that increase PRL secretion, albeit through different mechanisms, can increase the incidence of lateral prostate inflammation in the adult. (+info)Relevance of male accessory gland infection for subsequent fertility with special focus on prostatitis. (6/271)
Infections of the male genitourinary tract may contribute to infertility to a various extent depending on the site of inflammation. Especially in prostatitis, the exact classification of the infection contributes to its impact on changes in the ejaculate. Similarly, in urethritis, epididymitis and orchitis, only a clear clinical diagnosis allows a rational approach to altered sperm parameters. Several inflammatory and reactive alterations of sperm quality seem to be proven; nevertheless, the impact of these findings on male fertility remains in many cases unclear. Even therapeutic trials do not provide more insights into the association of male genital infections and impaired fertility, although the efficacy of antibiotic trials seems to be proven. For the future, it may be decisive to evaluate inflammatory changes in the ejaculate not only on the basis of standard but also on functional parameters, thus providing new definitions of the interactions between male urogenital tract infection and disturbances of male fertility. (+info)Treatment of prostatitis. (7/271)
The term prostatitis is applied to a series of disorders, ranging from acute bacterial infection to chronic pain syndromes, in which the prostate gland is inflamed. Patients present with a variety of symptoms, including urinary obstruction, fever, myalgias, decreased libido or impotence, painful ejaculation and low-back and perineal pain. Physical examination often fails to clarify the cause of the pain. Cultures and microscopic examination of urine and prostatic secretions before and after prostatic massage may help differentiate prostatitis caused by infection from prostatitis with other causes. Because the rate of occult infection is high, a therapeutic trial of antibiotics is often in order even when patients do not appear to have bacterial prostatitis. If the patient responds to therapy, antibiotics are continued for at least three to four weeks, although some men require treatment for several months. A patient who does not respond might be evaluated for chronic nonbacterial prostatitis, in which nonsteroidal anti-inflammatory drugs, alpha-blocking agents, anticholinergic agents or other therapies may provide symptomatic relief. (+info)A population pharmacokinetic analysis of the penetration of the prostate by levofloxacin. (8/271)
Prostatitis has remained a pathological entity that is difficult to treat. Part of the difficulty revolves about the putative offending pathogens. For acute prostatitis, members of the Enterobacteriaceae, particularly Escherichia coli, play a central role, while intracellular pathogens such as Chlamydia are more frequently seen in chronic prostatitis. Consequently, a drug needs to be able to penetrate to this specialized site in both the acute and chronic infection forms of the disease and also have potent activity against the most common causative pathogens, both intracellular and extracellular. Levofloxacin has such an activity profile. We wished to document its ability to penetrate to the site of infection. Patients undergoing prostatectomies were administered 500 mg of levofloxacin orally every 24 h for 2 days prior to surgery, and then on the day of surgery, 500 mg was administered as an hour-long, constant-rate intravenous (i.v.) infusion. A set of blood samples was obtained as guided by stochastic optimal design theory. Prostate biopsy times were determined by randomizing subjects into one of four groups, based on the interval after the i.v. dose. All plasma and prostate drug concentrations were comodeled by a population modeling program, BigNPEM, implemented on the Cray T3E Supercomputer housed at the Supercomputer Center at the University of California at San Diego. Penetration was determined as the ratio of the area under the concentration-time curve (AUC) of levofloxacin in the prostate to the plasma levofloxacin AUC. When calculated from the mean population parameters, this penetration ratio was 2.96. We also performed a 1,000-subject Monte Carlo simulation from the mean parameter vector and covariance matrix. The mean penetration ratio here was 4.14 with a 95% confidence interval of 0.20 to 19.6. Over 70% of the population had a penetration ratio in excess of 1.0. Levofloxacin adequately penetrates a noninflamed prostate and should be evaluated for the therapy of prostatitis. (+info)Prostatitis is a medical condition that refers to inflammation of the prostate gland, which can be caused by bacterial or non-bacterial factors. It can present with various symptoms such as pain in the lower abdomen, pelvis, or genital area, difficulty and/or painful urination, ejaculation pain, and flu-like symptoms. Prostatitis can be acute or chronic, and it is important to seek medical attention for proper diagnosis and treatment.
Pelvic pain is defined as discomfort or unpleasant sensation in the lower abdominal region, below the belly button, and between the hips. It can be acute (sudden and lasting for a short time) or chronic (persisting for months or even years), and it may be steady or intermittent, mild or severe. The pain can have various causes, including musculoskeletal issues, nerve irritation, infection, inflammation, or organic diseases in the reproductive, urinary, or gastrointestinal systems. Accurate diagnosis often requires a thorough medical evaluation to determine the underlying cause and develop an appropriate treatment plan.
The prostate is a small gland that is part of the male reproductive system. Its main function is to produce a fluid that, together with sperm cells from the testicles and fluids from other glands, makes up semen. This fluid nourishes and protects the sperm, helping it to survive and facilitating its movement.
The prostate is located below the bladder and in front of the rectum. It surrounds part of the urethra, the tube that carries urine and semen out of the body. This means that prostate problems can affect urination and sexual function. The prostate gland is about the size of a walnut in adult men.
Prostate health is an important aspect of male health, particularly as men age. Common prostate issues include benign prostatic hyperplasia (BPH), which is an enlarged prostate not caused by cancer, and prostate cancer, which is one of the most common types of cancer in men. Regular check-ups with a healthcare provider can help to detect any potential problems early and improve outcomes.
Prostatic diseases refer to a range of medical conditions that affect the prostate gland, a small gland that is part of the male reproductive system. The prostate is located below the bladder and surrounds the urethra, the tube that carries urine and semen out of the body. Some common prostatic diseases include:
1. Benign Prostatic Hyperplasia (BPH): This is a non-cancerous enlargement of the prostate gland that can cause difficulties with urination, such as a weak stream, frequent urination, and a feeling of incomplete bladder emptying.
2. Prostatitis: This is an inflammation or infection of the prostate gland that can cause pain, fever, difficulty urinating, and sexual dysfunction.
3. Prostate Cancer: This is a malignant tumor that develops in the prostate gland and can spread to other parts of the body. It is one of the most common types of cancer in men and can often be treated successfully if detected early.
4. Acute Bacterial Prostatitis: This is a sudden and severe infection of the prostate gland that can cause fever, chills, pain in the lower back and genital area, and difficulty urinating.
5. Chronic Bacterial Prostatitis: This is a recurring or persistent bacterial infection of the prostate gland that can cause symptoms similar to chronic pelvic pain syndrome.
6. Chronic Pelvic Pain Syndrome (CPPS): Also known as chronic nonbacterial prostatitis, this condition is characterized by ongoing pain in the pelvic area, often accompanied by urinary and sexual dysfunction. The exact cause of CPPS is not well understood, but it is thought to be related to inflammation or nerve damage in the prostate gland.
A chronic disease is a long-term medical condition that often progresses slowly over a period of years and requires ongoing management and care. These diseases are typically not fully curable, but symptoms can be managed to improve quality of life. Common chronic diseases include heart disease, stroke, cancer, diabetes, arthritis, and COPD (chronic obstructive pulmonary disease). They are often associated with advanced age, although they can also affect children and younger adults. Chronic diseases can have significant impacts on individuals' physical, emotional, and social well-being, as well as on healthcare systems and society at large.
I'm sorry for any confusion, but "Prostatein" is not a recognized term in medical literature or anatomy. It's possible there may be a misunderstanding or typo in your query. The prostate is a gland in males that is part of the reproductive system. If you have any questions about the prostate or related health concerns, I'd be happy to try and help clarify those.
Prostatic hyperplasia, also known as benign prostatic hyperplasia (BPH), is a noncancerous enlargement of the prostate gland. The prostate gland surrounds the urethra, the tube that carries urine and semen out of the body. When the prostate gland enlarges, it can squeeze or partially block the urethra, causing problems with urination, such as a weak stream, difficulty starting or stopping the flow, and more frequent urination, especially at night. Prostatic hyperplasia is a common condition as men age and does not necessarily lead to cancer. However, it can cause significant discomfort and decreased quality of life if left untreated. Treatment options include medications, minimally invasive procedures, and surgery.
Phellodendron is not a medical term itself, but it refers to a genus of trees and shrubs commonly found in Asia, particularly in China, Japan, and Korea. The bark of these plants, especially Phellodendron amurense and Phellodendron chinense, has been used in traditional Chinese medicine for centuries.
The medical definition pertains to the therapeutic use of the bark extracts or compounds derived from it. These extracts contain various alkaloids, such as berberine, palmatine, jatrorrhizine, and magnoflorine, which have been studied for their potential medicinal properties.
In modern medicine, Phellodendron is not widely recognized or used as a standalone treatment. However, some complementary and alternative medicine practitioners may recommend it for various purposes, such as treating gastrointestinal disorders, skin issues, or inflammation. It's essential to consult with a healthcare professional before starting any new treatments or supplements, including those derived from Phellodendron.
Mycoplasmatales infections refer to illnesses caused by bacteria belonging to the order Mycoplasmatales, which are characterized as the smallest self-replicating organisms lacking a cell wall. The most common pathogens in this group include Mycoplasma pneumoniae, M. genitalium, M. hominis, and Ureaplasma urealyticum.
Mycoplasma pneumoniae is a leading cause of community-acquired pneumonia, while M. genitalium is associated with sexually transmitted infections, including urethritis, cervicitis, and pelvic inflammatory disease. M. hominis and U. urealyticum are typically commensals but can cause invasive diseases such as septic arthritis, endocarditis, or meningitis, especially in immunocompromised individuals.
Infections caused by these organisms often present with nonspecific symptoms, making diagnosis challenging. Diagnosis usually involves serological tests, nucleic acid amplification techniques (NAATs), or culture methods. Treatment typically includes macrolides, tetracyclines, or fluoroquinolones, depending on the specific pathogen and its antibiotic susceptibility profile.
I'm sorry for any confusion, but "Gardenia" is not a medical term. It is the name of a genus of flowering plants in the coffee family, Rubiaceae. These plants are native to tropical and subtropical regions of Africa, Southern Asia, and Australia. The flowers of some Gardenia species are used in perfumes and traditional medicines due to their fragrance. If you have any questions about a specific medical term or concept, please let me know and I would be happy to help.
Urethritis is a medical condition that refers to the inflammation of the urethra, which is the tube that carries urine from the bladder out of the body. Urethritis can be caused by various factors, including bacterial or viral infections, chemical irritants, or trauma to the urethra.
The most common cause of urethritis is a bacterial infection, such as chlamydia or gonorrhea, which can be transmitted through sexual contact. Other symptoms of urethritis may include pain or burning during urination, discharge from the urethra, and frequent urination.
Urethritis is typically diagnosed through a physical examination and laboratory tests to identify the underlying cause of the inflammation. Treatment for urethritis depends on the cause but may include antibiotics or other medications to treat infections, as well as measures to relieve symptoms such as pain and discomfort.
"Polygonum" is a genus of plants, also known as "knotweed," that belongs to the family Polygonaceae. It includes various species, some of which have been used in traditional medicine. However, it does not have a specific medical definition as it refers to a group of plants and not a particular medical condition or treatment. Some species of Polygonum have been studied for their potential medicinal properties, such as anti-inflammatory, antioxidant, and antimicrobial effects. But, it is essential to note that further research is required to establish their safety and efficacy in clinical settings.
Epididymitis is defined as the inflammation of the epididymis, a curved tube-like structure located at the back of the testicle that stores and transports sperm. The inflammation can result from infection, trauma, or other causes, and may cause symptoms such as pain, swelling, and tenderness in the scrotum. In some cases, epididymitis may also be associated with urinary tract infections, sexually transmitted infections, or other medical conditions. Treatment typically involves antibiotics to treat any underlying infection, as well as pain relief measures and supportive care to help reduce symptoms and promote healing.
Pyelonephritis is a type of urinary tract infection (UTI) that involves the renal pelvis and the kidney parenchyma. It's typically caused by bacterial invasion, often via the ascending route from the lower urinary tract. The most common causative agent is Escherichia coli (E. coli), but other bacteria such as Klebsiella, Proteus, and Pseudomonas can also be responsible.
Acute pyelonephritis can lead to symptoms like fever, chills, flank pain, nausea, vomiting, and frequent or painful urination. If left untreated, it can potentially cause permanent kidney damage, sepsis, or other complications. Chronic pyelonephritis, on the other hand, is usually associated with underlying structural or functional abnormalities of the urinary tract.
Diagnosis typically involves a combination of clinical evaluation, urinalysis, and imaging studies, while treatment often consists of antibiotics tailored to the identified pathogen and the patient's overall health status.
A cellular phone, also known as a mobile phone, is a portable device that uses wireless cellular networks to make and receive voice, video, and data communications. The term "cellular" refers to the way that the network is divided into small geographical areas, or cells, each served by a low-power transmitter/receiver. As a user moves from one cell to another, the phone automatically connects to the nearest cell site, allowing for uninterrupted communication as long as the user remains within the coverage area of the network.
Cellular phones typically use digital technology and operate on a variety of frequency bands, depending on the region and the specific carrier. They are equipped with a rechargeable battery, an antenna, a display screen, and a keypad or touchscreen interface for dialing numbers, sending messages, and accessing various features and applications.
Modern cellular phones offer a wide range of functions beyond basic voice communication, including text messaging, multimedia messaging, email, web browsing, social media, gaming, and photography. They may also include features such as GPS navigation, music players, and mobile payment systems. Some high-end models even serve as portable computing devices, with powerful processors, large memory capacities, and advanced software applications.
Bacterial infections are caused by the invasion and multiplication of bacteria in or on tissues of the body. These infections can range from mild, like a common cold, to severe, such as pneumonia, meningitis, or sepsis. The symptoms of a bacterial infection depend on the type of bacteria invading the body and the area of the body that is affected.
Bacteria are single-celled microorganisms that can live in many different environments, including in the human body. While some bacteria are beneficial to humans and help with digestion or protect against harmful pathogens, others can cause illness and disease. When bacteria invade the body, they can release toxins and other harmful substances that damage tissues and trigger an immune response.
Bacterial infections can be treated with antibiotics, which work by killing or inhibiting the growth of bacteria. However, it is important to note that misuse or overuse of antibiotics can lead to antibiotic resistance, making treatment more difficult. It is also essential to complete the full course of antibiotics as prescribed, even if symptoms improve, to ensure that all bacteria are eliminated and reduce the risk of recurrence or development of antibiotic resistance.
Ciprofloxacin is a fluoroquinolone antibiotic that is used to treat various types of bacterial infections, including respiratory, urinary, and skin infections. It works by inhibiting the bacterial DNA gyrase, which is an enzyme necessary for bacterial replication and transcription. This leads to bacterial cell death. Ciprofloxacin is available in oral and injectable forms and is usually prescribed to be taken twice a day. Common side effects include nausea, diarrhea, and headache. It may also cause serious adverse reactions such as tendinitis, tendon rupture, peripheral neuropathy, and central nervous system effects. It is important to note that ciprofloxacin should not be used in patients with a history of hypersensitivity to fluoroquinolones and should be used with caution in patients with a history of seizures, brain injury, or other neurological conditions.
Medical definitions of "mobile applications" generally refer to software programs designed to run on mobile devices such as smartphones and tablets. These apps can perform various functions, including providing health information, tracking symptoms or medication use, offering interactive health education, facilitating communication with healthcare providers, and enabling remote monitoring of patients' health status. They may be used for a variety of purposes, such as promoting healthy behaviors, managing chronic conditions, or supporting medical decision-making. It is important to note that the quality and accuracy of health information provided by mobile apps can vary widely, and patients should consult with their healthcare providers before using them to make medical decisions.