Pseudobulbar Palsy
Paralysis
Crying
Laughter
Cerebral Palsy
Left atrial myxoma presenting as pseudobulbar palsy. (1/7)
A case of left atrial (LA) myxoma presenting as pseudobulbar palsy, due to multiple cerebral infarcts, without any cardiac manifestations, is presented. LA myxoma is rare cause of embolization to CNS causing ischemic infarcts. Due to multiple CNS infarcts patient can present with varied clinical picture and pseudobulbar palsy is not a very common presentation. It was a real diagnostic dilemma before LA myxoma was diagnosed on echocardiography. (+info)Pseudobulbar crying induced by stimulation in the region of the subthalamic nucleus. (2/7)
We describe a case of pseudobulbar crying associated with deep brain stimulation (DBS) in the region of the subthalamic nucleus (STN). Patients with pseudobulbar crying show no other evidence of subjective feelings of depression such as dysphoria, anhedonia, or vegetative signs. This may be accompanied by other symptoms of pseudobulbar palsy and has been reported to occur with ischaemic or structural lesions in both cortical and subcortical regions of the brain. Although depression has been observed to result from DBS in the region of the STN, pseudobulbar crying has not been reported. A single patient who reported the symptoms of pseudobulbar crying after placement of an STN DBS was tested in the off DBS and on DBS conditions. The patient was tested using all four DBS lead contacts and the observations and results of the examiners were recorded. The Geriatric Depression Scale was used to evaluate for depression in all of the conditions. The patient exhibited pseudobulbar crying when on monopolar stimulation at all four lead contacts. The pseudobulbar crying resolved off stimulation. This case describes another type of affective change that may be associated with stimulation in the region of or within the STN. Clinicians should be aware of this potential complication, the importance of differentiating it from stimulation induced depression, and its response to a serotonin reuptake inhibitor, such as sertraline. (+info)Adeno-associated virus transfer of a gene encoding SNAP-25 resistant to botulinum toxin A attenuates neuromuscular paralysis associated with botulism. (3/7)
(+info)Dextromethorphan/quinidine sulfate for pseudobulbar affect. (4/7)
(+info)Practice parameter update: the care of the patient with amyotrophic lateral sclerosis: multidisciplinary care, symptom management, and cognitive/behavioral impairment (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. (5/7)
(+info)PRISM: a novel research tool to assess the prevalence of pseudobulbar affect symptoms across neurological conditions. (6/7)
(+info)Foix-Chavany-Marie syndrome caused by bilateral opercular lesions: right side tumor and left side ischemic stroke.(7/7)
(+info)Pseudobulbar palsy is a neurological condition that affects the control of voluntary muscles used for speaking, swallowing, and facial expressions. It is caused by damage to the brain's corticobulbar tracts, which transmit signals from the cerebral cortex to the brainstem.
The condition is characterized by emotional lability, inappropriate crying or laughing, difficulty speaking (dysarthria), weakness of the face and tongue, difficulty swallowing (dysphagia), and poor articulation. These symptoms can significantly impact a person's quality of life and ability to perform daily activities.
Pseudobulbar palsy is often seen in patients with neurological disorders such as amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), Parkinson's disease, stroke, and brain injury. Treatment typically focuses on managing the underlying condition and providing supportive care to help improve communication and swallowing abilities. In some cases, medications may be used to help regulate emotional expression and reduce symptoms of pseudobulbar affect.
Paralysis is a loss of muscle function in part or all of your body. It can be localized, affecting only one specific area, or generalized, impacting multiple areas or even the entire body. Paralysis often occurs when something goes wrong with the way messages pass between your brain and muscles. In most cases, paralysis is caused by damage to the nervous system, especially the spinal cord. Other causes include stroke, trauma, infections, and various neurological disorders.
It's important to note that paralysis doesn't always mean a total loss of movement or feeling. Sometimes, it may just cause weakness or numbness in the affected area. The severity and extent of paralysis depend on the underlying cause and the location of the damage in the nervous system.
Crying is not a medical term itself, but it can be a symptom or a response to various medical and emotional conditions. In a broader sense, crying refers to the production of tears and the audible sounds that accompany this action due to strong emotions such as sadness, happiness, frustration, or pain.
From a physiological standpoint, crying involves the activation of the autonomic nervous system, which leads to the production of tears by the lacrimal glands and the contraction of various facial muscles responsible for the expression of emotion. The parasympathetic branch of the autonomic nervous system is primarily responsible for the initiation of crying, leading to increased tear production and a decrease in heart rate.
There are several types of crying:
1. Emotional crying: This type of crying is a response to strong emotional states such as sadness, joy, frustration, or anger. It can be accompanied by sobbing, which involves deep, convulsive breaths and audible sounds.
2. Reflex crying: This occurs when the eyes are irritated due to foreign particles, bright lights, or other environmental factors. The reflex is designed to protect the eyes by producing tears to wash away the irritant.
3. Basal tearing: This type of tear production is continuous and helps keep the eyes lubricated and protected from drying out. It occurs at a low rate throughout the day and is not typically associated with crying as an emotional response.
In summary, while crying is not a medical term per se, it can be indicative of various emotional or physical states that may warrant medical attention. For instance, excessive or inappropriate crying might be a sign of underlying neurological or psychological conditions and should be evaluated by a healthcare professional if it becomes a concern.
While I'm an assistant and not a doctor, I can share that laughter is not typically defined in a medical context. However, it's often studied in the field of psychology and health. Laughter is a human behavior characterized by involuntary vocalizations and facial expressions, often associated with positive emotions and humor.
From a physiological perspective, when we laugh, our bodies respond with a series of reactions. The diaphragm and abdominal muscles contract, causing us to breathe in and out rapidly, which can lead to increased heart rate and blood pressure. At the same time, the brain releases endorphins, which are chemicals associated with feelings of happiness and well-being.
In a medical context, laughter is sometimes used as a therapeutic tool. Laughter therapy, for instance, is used to promote physical and emotional health through intentional laughter exercises. It's believed that laughter can help reduce stress, improve mood, boost the immune system, and alleviate pain.
Cerebral palsy (CP) is a group of disorders that affect a person's ability to move and maintain balance and posture. According to the Mayo Clinic, CP is caused by abnormal brain development or damage to the developing brain that affects a child's ability to control movement.
The symptoms of cerebral palsy can vary in severity and may include:
* Spasticity (stiff or tight muscles)
* Rigidity (resistance to passive movement)
* Poor coordination and balance
* Weakness or paralysis
* Tremors or involuntary movements
* Abnormal gait or difficulty walking
* Difficulty with fine motor skills, such as writing or using utensils
* Speech and language difficulties
* Vision, hearing, or swallowing problems
It's important to note that cerebral palsy is not a progressive condition, meaning that it does not worsen over time. However, the symptoms may change over time, and some individuals with CP may experience additional medical conditions as they age.
Cerebral palsy is usually caused by brain damage that occurs before or during birth, but it can also be caused by brain injuries that occur in the first few years of life. Some possible causes of cerebral palsy include:
* Infections during pregnancy
* Lack of oxygen to the brain during delivery
* Traumatic head injury during birth
* Brain bleeding or stroke in the newborn period
* Genetic disorders
* Maternal illness or infection during pregnancy
There is no cure for cerebral palsy, but early intervention and treatment can help improve outcomes and quality of life. Treatment may include physical therapy, occupational therapy, speech therapy, medications to manage symptoms, surgery, and assistive devices such as braces or wheelchairs.
Pseudobulbar palsy
Bulbar palsy
Krembil Research Institute
Progressive supranuclear palsy
Witzelsucht
Foix-Chavany-Marie syndrome
CADASIL
Ulegyria
Progressive bulbar palsy
Heinrich Laehr
Merlin Stone
Charles Foix
Pallidotomy
Pseudobulbar affect
Disorders of consciousness
Grinker myelinopathy
ALS
Congenital bilateral perisylvian syndrome
Laughter
Polymicrogyria
Central pontine myelinolysis
List of diseases (M)
Vascular dementia
List of MeSH codes (C23)
Motor neuron diseases
List of MeSH codes (C10)
Halperin-Birk syndrome
List of people with motor neuron disease
Pseudodysphagia
Crying
Pseudobulbar palsy - Wikipedia
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MeSH Browser
MeSH Browser
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Bulbar4
- Corticobulbar tract Bulbar palsy, a similar syndrome caused by the damage of lower motor neurons. (wikipedia.org)
- Bulbar and Pseudobulbar Palsy. (wikipedia.org)
- What is Bulbar Palsy? (wikipedia.org)
- Bulbar palsy(Latin syndroma bulbare), also known as bulbar palsy, is a neurological disease syndrome resulting from damage to the nuclei of the cranial nerves, which are located in the medulla medulla (glossopharyngeal, vagus and sublingual nerve). (medicalwholesome.com)
Bilateral4
- It has been suggested that the majority of patients with pathological laughter and crying have pseudobulbar palsy due to bilateral corticobulbar lesions and often a bipyramidal involvement of arms and legs. (wikipedia.org)
- 4 In patients with supranuclear lesions of the trigeminal nerve (eg, amyotrophic lateral sclerosis, extensive multiple sclerosis, bilateral corticobulbar infarction with pseudobulbar palsy), the jaw jerk is exaggerated and clonus may occur. (bmj.com)
- E - Emotional lability may accompany bilateral facial weakness and a brisk jaw jerk in cases of pseudobulbar palsy. (medicalsupernotes.com)
- S - Severe and bilateral corticobulbar lesions can result in pseudobulbar palsy, characterized by dysarthria, dysphagia, and dysphonia. (medicalsupernotes.com)
Dysphagia1
- Signs and symptoms of pseudobulbar palsy include: Slow and indistinct speech Dysphagia (difficulty in swallowing) Small, stiff and spastic tongue Brisk jaw jerk Dysarthria Labile affect Gag reflex may be normal, exaggerated or absent Examination may reveal upper motor neuron lesion of the limbs Pseudobulbar palsy is the result of damage of motor fibers traveling from the cerebral cortex to the lower brain stem. (wikipedia.org)
Syndrome4
- citation needed] Since pseudobulbar palsy is a syndrome associated with other diseases, treating the underlying disease may eventually reduce the symptoms of pseudobulbar palsy. (wikipedia.org)
- Is the syndrome of pathological laughing and crying a manifestation of pseudobulbar palsy? (wikipedia.org)
- Background Consanguineous kindred presented with an autosomal recessive syndrome of intrauterine growth retardation, marked developmental delay, spastic quadriplegia with profound contractures, pseudobulbar palsy with recurrent aspirations, epilepsy, dysmorphism, neurosensory deafness and optic nerve atrophy with no eye fixation. (bmj.com)
- Subsequently, patients with progressive supranuclear palsy develop ophthalmoplegia, pseudobulbar syndrome, emotional and cognitive impairment. (symptomsus.com)
Meningioma1
- 7. Occipital Interhemispheric Transtentorial Approach for a Pineal Region Meningioma with Pseudobulbar Palsy. (nih.gov)
Affect4
- citation needed] Possible pharmacological interventions for pseudobulbar affect include the tricyclic antidepressants, serotonin reuptake inhibitors, and a novel approach utilizing dextromethorphan and quinidine sulfate. (wikipedia.org)
- Nuedexta is an FDA approved medication for pseudobulbar affect. (wikipedia.org)
- Pseudobulbar affect (PBA) is a neuropsychiatric disorder consisting of brief emotional outbursts thought to be caused by disruption of corticobulbar or cortico-subcortical-thalamo-cerebellar circuitry. (unboundmedicine.com)
- www.unboundmedicine.com/5minute/view/5-Minute-Clinical-Consult/117649/all/Pseudobulbar_Affect. (unboundmedicine.com)
Diagnosis1
- Diagnosis of pseudobulbar palsy is based on observation of the symptoms of the condition. (wikipedia.org)
Emotional1
- Dextromethorphan, an N-methyl-D-aspartate receptor antagonist, inhibits glutamatergic transmission in the regions of the brainstem and cerebellum, which are hypothesized to be involved in pseudobulbar symptoms, and acts as a sigma ligand, binding to the sigma-1 receptors that mediate the emotional motor expression. (wikipedia.org)
Brain1
- The pseudobulbar crying could also be induced by stimulation in the region of the subthalamic nucleus of the brain. (wikipedia.org)
Patient1
- Behavorial changes can also be seen in a Pseudobulbar palsy patient. (medicowesome.com)
Nerve2
- The pudendal nerve, derived from S2, S3 and S4, leaves the pelvis m edial to the sciatic nerve via the higher sciatic foram en. (dnahelix.com)
- Furthermore, excessive bone tends to obturate cranial nerve foramina and provoke cranial nerve palsy . (symptoma.com)
Result1
- The disadvantages of epidural anaesthesia are that a few wom en com plain of dizziness or shivering, and that it m ay increase the length of the second stage and result in a rise in operative vaginal deliveries. (dnahelix.com)