Rheumatic Fever
Rheumatic Heart Disease
Rheumatic Diseases
Chorea
Streptococcus pyogenes
Penicillin G Benzathine
Grenada
Northern Territory
Myocarditis
Rheumatic Nodule
Heart Valve Diseases
Q Fever
Scarlet Fever
Oceanic Ancestry Group
Streptococcus
Arthritis, Reactive
Yellow Fever
Mitral Valve Insufficiency
Typhoid Fever
New Caledonia
Adams-Stokes Syndrome
Aortic Valve Insufficiency
Penicillins
Heart Murmurs
International Council of Nurses
Mitral Valve Stenosis
Glomerulonephritis
Bacterial Outer Membrane Proteins
Arthritis
Rheumatic chorea in northern Australia: a clinical and epidemiological study. (1/268)
To describe the epidemiology and clinical features of Sydenham's chorea in the Aboriginal population of northern Australia a review was conducted of 158 episodes in 108 people: 106 were Aborigines, 79 were female, and the mean age was 10.9 years at first episode. Chorea occurred in 28% of cases of acute rheumatic fever, carditis occurred in 25% of episodes of chorea, and arthritis in 8%. Patients with carditis or arthritis tended to have raised acute phase reactants and streptococcal serology. Two episodes lasted at least 30 months. Mean time to first recurrence of chorea was 2.1 years compared with 1.2 years to second recurrence. Established rheumatic heart disease developed in 58% of cases and was more likely in those presenting with acute carditis, although most people who developed rheumatic heart disease did not have evidence of acute carditis with chorea. Differences in the patterns of chorea and other manifestations of acute rheumatic fever in different populations may hold clues to its pathogenesis. Long term adherence to secondary prophylaxis is crucial following all episodes of acute rheumatic fever, including chorea, to prevent recurrence. (+info)Superantigen-induced T cell responses in acute rheumatic fever and chronic rheumatic heart disease patients. (2/268)
CD4+ and CD8+ T cells from healthy donors, acute rheumatic fever (ARF) and chronic rheumatic heart disease (CRHD) patients responded variably to a superantigen from Streptococcus pyogenes--Streptococcal pyrogenic erythrogenic toxin A (SPE-A). In vitro culture of CD4+ T cells from ARF patients (CD4-ARF) with SPE-A exhibited a Th1 type of response as they produced high levels of IL-2, while CD4+ T cells from CRHD patients (CD4-RHD) secreted IL-4 and IL-10 in large amounts, i.e. Th2 type of cytokine profile. The skewing of human CD4+ T cells (in response to SPE-A stimulation) to Th1 or Th2 type reflects the role of the two subsets in a disorder with differing intensities at the two extremes of the spectrum. Moreover, the anergy induction experiments revealed that CD8-ARF and CD8-RHD undergo anergy (to different extents), whereas CD4+ T cells do not, in response to re-stimulation by SPE-A. These results initially demonstrate that both CD4+ and CD8+ T cells respond differentially to SPE-A, and hence it is an important observation with respect to the pathogenesis of ARF/CRHD. Anergy in CD8+ T cells in the presence of SPE-A in vitro goes a step further to show the clinical relevance of these cells and their possible role in suppression of the disease. (+info)Rheumatic disease and the Australian aborigine. (3/268)
OBJECTIVE: To document the frequency and disease phenotype of various rheumatic diseases in the Australian Aborigine. METHODS: A comprehensive review was performed of the archaeological, ethnohistorical, and contemporary literature relating to rheumatic diseases in these indigenous people. RESULTS: No evidence was found to suggest that rheumatoid arthritis (RA), ankylosing spondylitis (AS), or gout occurred in Aborigines before or during the early stages of white settlement of Australia. Part of the explanation for the absence of these disorders in this indigenous group may relate to the scarcity of predisposing genetic elements, for example, shared rheumatoid epitope for RA, B27 antigen for AS. In contrast, osteoarthritis appeared to be common particularly involving the temporomandibular joint, right elbow and knees and, most probably, was related to excessive joint loading in their hunter gatherer lifestyle. Since white settlement, high frequency rates for rheumatic fever, systemic lupus erythematosus, and pyogenic arthritis have been observed and there are now scanty reports of the emergence of RA and gout in these original Australians. CONCLUSION: The occurrence and phenotype of various rheumatic disorders in Australian Aborigines is distinctive but with recent changes in diet, lifestyle, and continuing genetic admixture may be undergoing change. An examination of rheumatic diseases in Australian Aborigines and its changing phenotype may lead to a greater understanding of the aetiopathogenesis of these disorders. (+info)Functional analysis of IgA antibodies specific for a conserved epitope within the M protein of group A streptococci from Australian Aboriginal endemic communities. (4/268)
The mucosa is one of the initial sites of group A streptococcal (GAS) infection and salivary IgA (sIgA) is thought to be critical to immunity. However, the target epitopes of sIgA and the function of sIgA in GAS immunity, in particular the role of accessory cells and complement, is largely unknown. We studied the aquisition and the function of sIgA specific for a conserved region epitope, p145 (sequence: LRRDLDASREAKKQVEKALE) of the M protein. Peptide 145-specific sIgA is highly prevalent within an Aboriginal population living in an area endemic for GAS and acquisition of p145-specific sIgA increases with age, consistent with a role for such antibodies in immunity to GAS. Human sIgA and IgG specific for p145 were affinity purified and shown to opsonize M5 GAS in vitro. Opsonization could be specifically inhibited by the addition of free p145 to the antibodies during assay. Opsonization of GAS was totally dependent on the presence of both complement and polymorphonuclear leukocytes, and, moreover, affinity-purified p145-specific sIgA was shown to fix complement in the presence of M5 GAS. These data show that mucosal IgA to this conserved region peptide within the M protein has an important role in human immunity against GAS and may be useful in a broad-based cross-protective anti-streptococcal vaccine. (+info)HLA molecules, bacteria and autoimmunity. (5/268)
It has been well established that many diseases are linked to HLA antigens. Two of the most interesting HLA associations may provide some insight into the pathogenesis of rheumatic inflammatory conditions. In ankylosing spondylitis (AS), 96% of patients possess HLA-B27, whilst the frequency of this marker in the general population is c. 8%. In rheumatoid arthritis (RA), >90% of patients possess either HLA-DR1 or some subtypes of HLA-DR4, whilst the frequency of this marker in the general population is c. 35%. The association between HLA-B27 and reactive arthritis (ReA) has also been well established. Furthermore, it has been shown that ReA is triggered by infection via the gastrointestinal tract due to Yersinia, Salmonella or Campylobacter spp. and in the genitourinary tract due to chlamydia. In a similar way, microbiological and immunological studies have revealed an association between Klebsiella pneumoniae in AS and Proteus mirabilis in RA. This article reviews the possible pathological implications of the associations between HLA-B27, K. pneumoniae and AS, as well as HLA-DR1/DR4, P. mirabilis and RA. (+info)Rheumatic fever--is it still a problem? (6/268)
The incidence of rheumatic fever has declined in industrialized countries since the 1950s and now has an annual incidence of around 0.5 cases per 100,000 children of school age. In developing countries it remains an endemic disease with annual incidences ranging from 100 to 200 per 100,000 school-aged children and is a major cause of cardiovascular mortality. Interest in the pathogenesis of rheumatic fever was rekindled by outbreaks in the USA (1985-1987) and the rare cases still seen in industrialized countries. The current concept is that the disease results from the host's poorly adapted autoimmune response to group A beta-haemolytic streptococci. The risk of developing rheumatic fever following untreated tonsillopharyngitis is 1% in the civilian population. Knowledge of virulence factors has been greatly enriched by progress in molecular biology. One of the key elements is protein M, a surface protein on the bacterial wall which carries specific epitopes. Several serotypes which lead to rheumatic fever have been recognized among more than 80 identified serotypes. However, the reason why specific strains within a given serotype have increased rheumatogenic virulence remains unknown. The causal strain adheres to the oral and pharyngeal cells and then releases its degradation products. These products present antigenic determinants which cross-react with certain human tissues, particularly in cardiac valve tissue and myocardium. Diagnosis is now difficult owing to the low incidence. Late diagnosis can have serious consequences and acute rheumatic fever is a therapeutic emergency requiring immediate antibiotic and anti-inflammatory treatment. In most of Europe there is tacit agreement that all cases of pharyngitis and tonsillitis should be treated with antibiotics without identification of the causal agent despite the fact that only about 20% of the cases are caused by group A beta-haemolytic streptococci, and could lead to rheumatic fever. (+info)Comparison of short-course (5 day) cefuroxime axetil with a standard 10 day oral penicillin V regimen in the treatment of tonsillopharyngitis. (7/268)
Oral penicillin V given three times daily in doses of 50,000-100,000 IU daily has been the standard treatment for tonsillopharyngitis for the last few decades. These regimens, initially recommended by the American Heart Association, were extrapolated from i.v. dosing with long-acting forms of penicillin which had been shown to prevent post-streptococcal sequelae. More recently, several antibiotics, including cefuroxime axetil, have been shown to be at least as effective as penicillin G in eradicating group A beta-haemolytic streptococci (GABHS) but their influence on post-streptococcal sequelae has never been assessed in a large-scale trial. The German Society for Pediatric Infectious Diseases (DGPI) undertook a large study of culture-proven tonsillopharyngitis involving several agents and included a 1 year follow-up to establish the effect on sequelae. In one arm of this study, cefuroxime 250 mg bid was compared with 50,000 IU penicillin V given in three divided doses. Cefuroxime axetil was more effective than oral penicillin V in eradicating GABHS at the assessment 2-4 days post-treatment (441/490 (90%) patients versus 1196/1422 (84%) patients; P = 0.001). Clinically, the two agents were equivalent in efficacy, and carriage rates were similar (11.1% and 13.8%, respectively) in patients receiving cefuroxime axetil and penicillin V, 7-8 weeks post-treatment. One case of glomerular nephritis occurred in a patient given penicillin V. There were no post-streptococcal sequelae confirmed for patients treated with cefuroxime axetil. The findings confirm the previously reported efficacy of short-course (4-5 day) treatments with cefuroxime axetil and indicate that short-course treatment is comparable to the standard oral penicillin V regimen in preventing post-streptococcal sequelae. (+info)Evaluation of the approach of primary care physicians to the management of streptococcal pharyngotonsillitis. IPROS Network. (8/268)
BACKGROUND: Streptococcal pharyngotonsillitis remains a common illness in children and can lead to serious complications if left untreated. OBJECTIVE: To evaluate the diagnostic and management approach of a sample of primary care physicians in the largest sick fund in Israel to streptococcal pharyngotonsillitis in children. METHODS: A questionnaire was mailed to all physicians who treat children and are employed by the General Health Services (Kupat Holim Klalit) in the Jerusalem District. The questionnaire included data on demographics, practice type and size, and availability of throat culture and rapid strep test; as well as a description of three hypothetical cases followed by questions relating to their diagnosis and treatment. RESULTS: Of the 188 eligible physicians, 118 (62.5%) responded, including 65 of 89 pediatricians (73%) and 53 of 99 family and general practitioners (53.5%). Fifty-six physicians (47.4%) had more than 18 years experience, and 82 (70%) completed specialization in Israel. Mean practice size was 950 patients. Fifty-three physicians (43%) worked in Kupat Holim community clinics, 25 (21%) worked independently in private clinics, and 40 (34%) did both. A total of 91 (77%) had access to laboratory facilities for daily throat culture. The time it took for the results to arrive was 48 to 72 hours. For the three clinical scenarios, 90% of the physicians accurately evaluated case A, a 1-year-old with viral pharyngotonsillitis, and 100 (85%) correctly diagnosed case C, a 7-year-old with streptococcal infection. As expected, opinions were divided on case B, a 3-year-old child with uncertain diagnosis. Accordingly, 75 (65.3%) physicians did not recommend treatment for case A, compared to 109 (92.5%) for case C. For case B, 22 (19%) said they would always treat, 43 (36%) would sometimes treat, and 35 (30%) would await the result of the throat culture. For 104 (88%) physicians the antibiotic of choice for case C was penicillin, while only 9 (7.5%) chose amoxicillin. However, the recommended dosage regimens varied from 250 to 500 mg per dose, and from two to four doses daily. For case C, 110 physicians (93%) chose a 10 day duration of treatment. CONCLUSIONS: The primary care physicians in the sample (pediatricians, general practitioners and family physicians) accurately diagnosed viral and streptococcal pharyngotonsillitis. However, there was a lack of uniformity regarding its management in general, and the dosage regimen for penicillin in particular. (+info)Rheumatic fever is a systemic inflammatory disease that may occur following an untreated Group A streptococcal infection, such as strep throat. It primarily affects children between the ages of 5 and 15, but it can occur at any age. The condition is characterized by inflammation in various parts of the body, including the heart (carditis), joints (arthritis), skin (erythema marginatum, subcutaneous nodules), and brain (Sydenham's chorea).
The onset of rheumatic fever usually occurs 2-4 weeks after a streptococcal infection. The exact cause of the immune system's overreaction leading to rheumatic fever is not fully understood, but it involves molecular mimicry between streptococcal antigens and host tissues.
The Jones Criteria are used to diagnose rheumatic fever, which include:
1. Evidence of a preceding streptococcal infection (e.g., positive throat culture or rapid strep test, elevated or rising anti-streptolysin O titer)
2. Carditis (heart inflammation), including new murmurs or changes in existing murmurs, electrocardiogram abnormalities, or evidence of heart failure
3. Polyarthritis (inflammation of multiple joints) – typically large joints like the knees and ankles, migratory, and may be associated with warmth, swelling, and pain
4. Erythema marginatum (a skin rash characterized by pink or red, irregularly shaped macules or rings that blanch in the center and spread outward)
5. Subcutaneous nodules (firm, round, mobile lumps under the skin, usually over bony prominences)
6. Sydenham's chorea (involuntary, rapid, irregular movements, often affecting the face, hands, and feet)
Treatment of rheumatic fever typically involves antibiotics to eliminate any residual streptococcal infection, anti-inflammatory medications like corticosteroids or nonsteroidal anti-inflammatory drugs (NSAIDs) to manage symptoms and prevent long-term heart complications, and secondary prophylaxis with regular antibiotic administration to prevent recurrent streptococcal infections.
Rheumatic Heart Disease (RHD) is defined as a chronic heart condition caused by damage to the heart valves due to untreated or inadequately treated streptococcal throat infection (strep throat). The immune system's response to this infection can mistakenly attack and damage the heart tissue, leading to inflammation and scarring of the heart valves. This damage can result in narrowing, leakage, or abnormal functioning of the heart valves, which can further lead to complications such as heart failure, stroke, or infective endocarditis.
RHD is a preventable and treatable condition if detected early and managed effectively. It primarily affects children and young adults in developing countries where access to healthcare and antibiotics for strep throat infections may be limited. Long-term management of RHD typically involves medications, regular monitoring, and sometimes surgical intervention to repair or replace damaged heart valves.
Rheumatic diseases are a group of disorders that cause pain, stiffness, and swelling in the joints, muscles, tendons, ligaments, or bones. They include conditions such as rheumatoid arthritis, osteoarthritis, systemic lupus erythematosus (SLE), gout, ankylosing spondylitis, psoriatic arthritis, and many others. These diseases can also affect other body systems including the skin, eyes, lungs, heart, kidneys, and nervous system. Rheumatic diseases are often chronic and may be progressive, meaning they can worsen over time. They can cause significant pain, disability, and reduced quality of life if not properly diagnosed and managed. The exact causes of rheumatic diseases are not fully understood, but genetics, environmental factors, and immune system dysfunction are believed to play a role in their development.
Chorea is a medical term that describes an involuntary movement disorder characterized by brief, irregular, and abrupt jerky movements. These movements often occur randomly and can affect any part of the body. Chorea can also cause difficulty with coordination and balance, and can sometimes be accompanied by muscle weakness or rigidity.
The term "chorea" comes from the Greek word "χορεία" (khoréia), which means "dance," reflecting the graceful, dance-like movements that are characteristic of this condition. Chorea can occur as a symptom of various underlying medical conditions, including neurological disorders such as Huntington's disease, Sydenham's chorea, and cerebral palsy, as well as metabolic disorders, infections, and certain medications.
Treatment for chorea depends on the underlying cause of the condition and may include medications to help control the involuntary movements, physical therapy to improve coordination and balance, and lifestyle modifications to reduce the risk of injury from falls or other accidents. In some cases, surgery may be recommended as a last resort for severe or refractory chorea.
Streptococcus pyogenes is a Gram-positive, beta-hemolytic streptococcus bacterium that causes various suppurative (pus-forming) and nonsuppurative infections in humans. It is also known as group A Streptococcus (GAS) due to its ability to produce the M protein, which confers type-specific antigenicity and allows for serological classification into more than 200 distinct Lancefield groups.
S. pyogenes is responsible for a wide range of clinical manifestations, including pharyngitis (strep throat), impetigo, cellulitis, erysipelas, scarlet fever, rheumatic fever, and acute poststreptococcal glomerulonephritis. In rare cases, it can lead to invasive diseases such as necrotizing fasciitis (flesh-eating disease) and streptococcal toxic shock syndrome (STSS).
The bacterium is typically transmitted through respiratory droplets or direct contact with infected skin lesions. Effective prevention strategies include good hygiene practices, such as frequent handwashing and avoiding sharing personal items, as well as prompt recognition and treatment of infections to prevent spread.
Antistreptolysin (ASO) is a type of antibody that the body produces in response to an infection caused by Streptococcus pyogenes, a species of bacteria commonly known as group A streptococcus. This bacterium produces a toxin called streptolysin O, which can damage tissues and cells in the body. The ASO antibodies are produced by the immune system to help neutralize the effects of this toxin and protect against further tissue damage.
ASO titers, or levels of these antibodies in the blood, can be measured through a laboratory test called an antistreptolysin O titer test. This test is often used to help diagnose recent streptococcal infections, such as strep throat, and to monitor the effectiveness of treatment. Elevated ASO titers may indicate a recent or ongoing infection with group A streptococcus, while normal or decreasing titers suggest that the infection has resolved.
It's important to note that a positive ASO test does not necessarily mean that a person is currently infected with group A streptococcus, as these antibodies can persist in the blood for several months after an infection has cleared. Therefore, the test should be interpreted in conjunction with other clinical findings and laboratory results.
Pharyngitis is the medical term for inflammation of the pharynx, which is the back portion of the throat. This condition is often characterized by symptoms such as sore throat, difficulty swallowing, and scratchiness in the throat. Pharyngitis can be caused by a variety of factors, including viral infections (such as the common cold), bacterial infections (such as strep throat), and irritants (such as smoke or chemical fumes). Treatment for pharyngitis depends on the underlying cause of the condition, but may include medications to relieve symptoms or antibiotics to treat a bacterial infection.
Fever, also known as pyrexia or febrile response, is a common medical sign characterized by an elevation in core body temperature above the normal range of 36.5-37.5°C (97.7-99.5°F) due to a dysregulation of the body's thermoregulatory system. It is often a response to an infection, inflammation, or other underlying medical conditions, and it serves as a part of the immune system's effort to combat the invading pathogens or to repair damaged tissues.
Fevers can be classified based on their magnitude:
* Low-grade fever: 37.5-38°C (99.5-100.4°F)
* Moderate fever: 38-39°C (100.4-102.2°F)
* High-grade or severe fever: above 39°C (102.2°F)
It is important to note that a single elevated temperature reading does not necessarily indicate the presence of a fever, as body temperature can fluctuate throughout the day and can be influenced by various factors such as physical activity, environmental conditions, and the menstrual cycle in females. The diagnosis of fever typically requires the confirmation of an elevated core body temperature on at least two occasions or a consistently high temperature over a period of time.
While fevers are generally considered beneficial in fighting off infections and promoting recovery, extremely high temperatures or prolonged febrile states may necessitate medical intervention to prevent potential complications such as dehydration, seizures, or damage to vital organs.
Streptococcal infections are a type of infection caused by group A Streptococcus bacteria (Streptococcus pyogenes). These bacteria can cause a variety of illnesses, ranging from mild skin infections to serious and potentially life-threatening conditions such as sepsis, pneumonia, and necrotizing fasciitis (flesh-eating disease).
Some common types of streptococcal infections include:
* Streptococcal pharyngitis (strep throat) - an infection of the throat and tonsils that can cause sore throat, fever, and swollen lymph nodes.
* Impetigo - a highly contagious skin infection that causes sores or blisters on the skin.
* Cellulitis - a bacterial infection of the deeper layers of the skin and underlying tissue that can cause redness, swelling, pain, and warmth in the affected area.
* Scarlet fever - a streptococcal infection that causes a bright red rash on the body, high fever, and sore throat.
* Necrotizing fasciitis - a rare but serious bacterial infection that can cause tissue death and destruction of the muscles and fascia (the tissue that covers the muscles).
Treatment for streptococcal infections typically involves antibiotics to kill the bacteria causing the infection. It is important to seek medical attention if you suspect a streptococcal infection, as prompt treatment can help prevent serious complications.
Penicillin G Benzathine is a type of antibiotic that is used to treat various bacterial infections. According to the International Journal of Antimicrobial Agents, Penicillin G Benzathine is a "water-soluble salt of penicillin G, which has a very high degree of stability and provides prolonged low-level serum concentrations after intramuscular injection."
It is often used to treat infections caused by streptococci and treponema pallidum, the bacterium that causes syphilis. Penicillin G Benzathine works by interfering with the ability of these bacteria to form a cell wall, which is essential for their survival. Without a functional cell wall, the bacteria are unable to grow and multiply, and are eventually destroyed by the body's immune system.
Penicillin G Benzathine is typically administered via intramuscular injection, and its prolonged release allows for less frequent dosing compared to other forms of penicillin. However, it may not be suitable for all patients, particularly those with a history of allergic reactions to penicillin or other antibiotics. As with any medication, Penicillin G Benzathine should only be used under the supervision of a healthcare provider.
I'm sorry for any confusion, but "Grenada" is not a medical term. It is a country, specifically an island nation in the Caribbean. If you have any questions about medical terms or concepts, I would be happy to help answer those!
I'm sorry for any confusion, but "Northern Territory" is not a medical term. It is a geographical and political term referring to a federal territory in Australia. If you have any questions about medical terminology or concepts, I would be happy to help with those!
An acute disease is a medical condition that has a rapid onset, develops quickly, and tends to be short in duration. Acute diseases can range from minor illnesses such as a common cold or flu, to more severe conditions such as pneumonia, meningitis, or a heart attack. These types of diseases often have clear symptoms that are easy to identify, and they may require immediate medical attention or treatment.
Acute diseases are typically caused by an external agent or factor, such as a bacterial or viral infection, a toxin, or an injury. They can also be the result of a sudden worsening of an existing chronic condition. In general, acute diseases are distinct from chronic diseases, which are long-term medical conditions that develop slowly over time and may require ongoing management and treatment.
Examples of acute diseases include:
* Acute bronchitis: a sudden inflammation of the airways in the lungs, often caused by a viral infection.
* Appendicitis: an inflammation of the appendix that can cause severe pain and requires surgical removal.
* Gastroenteritis: an inflammation of the stomach and intestines, often caused by a viral or bacterial infection.
* Migraine headaches: intense headaches that can last for hours or days, and are often accompanied by nausea, vomiting, and sensitivity to light and sound.
* Myocardial infarction (heart attack): a sudden blockage of blood flow to the heart muscle, often caused by a buildup of plaque in the coronary arteries.
* Pneumonia: an infection of the lungs that can cause coughing, chest pain, and difficulty breathing.
* Sinusitis: an inflammation of the sinuses, often caused by a viral or bacterial infection.
It's important to note that while some acute diseases may resolve on their own with rest and supportive care, others may require medical intervention or treatment to prevent complications and promote recovery. If you are experiencing symptoms of an acute disease, it is always best to seek medical attention to ensure proper diagnosis and treatment.
Myocarditis is an inflammation of the myocardium, which is the middle layer of the heart wall. The myocardium is composed of cardiac muscle cells and is responsible for the heart's pumping function. Myocarditis can be caused by various infectious and non-infectious agents, including viruses, bacteria, fungi, parasites, autoimmune diseases, toxins, and drugs.
In myocarditis, the inflammation can damage the cardiac muscle cells, leading to decreased heart function, arrhythmias (irregular heart rhythms), and in severe cases, heart failure or even sudden death. Symptoms of myocarditis may include chest pain, shortness of breath, fatigue, palpitations, and swelling in the legs, ankles, or abdomen.
The diagnosis of myocarditis is often based on a combination of clinical presentation, laboratory tests, electrocardiogram (ECG), echocardiography, cardiac magnetic resonance imaging (MRI), and endomyocardial biopsy. Treatment depends on the underlying cause and severity of the disease and may include medications to support heart function, reduce inflammation, control arrhythmias, and prevent further damage to the heart muscle. In some cases, hospitalization and intensive care may be necessary.
A rheumatic nodule is not a specific medical definition, but rather a descriptive term for a type of nodule that can be found in certain medical conditions. These nodules are typically associated with rheumatoid arthritis (RA), although they can also occur in other diseases such as systemic lupus erythematosus (SLE) and dermatomyositis.
Rheumatic nodules are small, firm, round or oval-shaped lumps that develop under the skin or in certain organs such as the lungs. They can vary in size from a few millimeters to several centimeters in diameter. In RA, these nodules usually appear on the forearms, elbows, fingers, knees, and ankles, although they can occur in other areas of the body as well.
Histologically, rheumatic nodules are characterized by a central area of fibrinoid necrosis surrounded by palisading histiocytes and fibroblasts. They may also contain lymphocytes, plasma cells, and eosinophils. The presence of these nodules is thought to be related to the immune system's response to the underlying disease process, although their exact cause and significance are not fully understood.
It is important to note that rheumatic nodules can also occur in individuals without any known medical condition, and their presence does not necessarily indicate the presence of a specific disease. However, if you notice any new or unusual lumps or bumps on your body, it is always a good idea to consult with a healthcare professional for further evaluation and diagnosis.
Heart valve diseases are a group of conditions that affect the function of one or more of the heart's four valves (tricuspid, pulmonic, mitral, and aortic). These valves are responsible for controlling the direction and flow of blood through the heart. Heart valve diseases can cause the valves to become narrowed (stenosis), leaky (regurgitation or insufficiency), or improperly closed (prolapse), leading to disrupted blood flow within the heart and potentially causing symptoms such as shortness of breath, fatigue, chest pain, and irregular heart rhythms. The causes of heart valve diseases can include congenital defects, age-related degenerative changes, infections, rheumatic heart disease, and high blood pressure. Treatment options may include medications, surgical repair or replacement of the affected valve(s), or transcatheter procedures.
Pyoderma is a term used in medicine to describe a bacterial skin infection. It's derived from two Greek words: "pyon" meaning pus and "derma" meaning skin.
The infection can result in inflammation, often characterized by redness, swelling, warmth, and pain. Pus-filled blisters or boils may also form, which can rupture and crust over as the infection progresses.
Pyoderma can occur in people of all ages but is particularly common in children. The causative bacteria are often Staphylococcus aureus or Streptococcus pyogenes. The condition can be superficial, affecting only the top layer of the skin (epidermis), or it can be deeper, involving the dermis and/or subcutaneous tissue.
Treatment typically involves antibiotics, either topical or oral, depending on the severity and extent of the infection. In some cases, drainage of pus-filled abscesses may be necessary. Preventive measures such as good hygiene and keeping skin clean and dry can help reduce the risk of pyoderma.
Q fever is a zoonotic disease caused by the bacterium Coxiella burnetii. It is characterized by acute or chronic flu-like symptoms, pneumonia, and hepatitis. The bacteria are primarily transmitted to humans through inhalation of contaminated dust or aerosols from infected animals such as cattle, sheep, and goats. Q fever can also be transmitted through consumption of unpasteurized milk or direct contact with infected animals. It is often asymptomatic or mildly symptomatic in animals but can cause severe disease in humans.
The acute form of Q fever typically presents with sudden onset of high fever, severe headache, fatigue, muscle pain, and cough. Some patients may also develop pneumonia or hepatitis. The chronic form of the disease is less common but more serious, often affecting people with compromised immune systems. Chronic Q fever can lead to endocarditis, an infection of the inner lining of the heart, which can be life-threatening if left untreated.
Diagnosis of Q fever typically involves a combination of clinical evaluation, serological testing, and PCR (polymerase chain reaction) assays. Treatment usually involves antibiotics such as doxycycline or fluoroquinolones for several weeks to months, depending on the severity and duration of the illness. Prevention measures include avoiding contact with infected animals, wearing protective clothing and masks when handling animal products, and pasteurizing milk before consumption.
Streptococcal vaccines are immunizations designed to protect against infections caused by Streptococcus bacteria. These vaccines contain antigens, which are substances that trigger an immune response and help the body recognize and fight off specific types of Streptococcus bacteria. There are several different types of streptococcal vaccines available or in development, including:
1. Pneumococcal conjugate vaccine (PCV): This vaccine protects against Streptococcus pneumoniae, a type of bacteria that can cause pneumonia, meningitis, and other serious infections. PCV is recommended for all children under 2 years old, as well as older children and adults with certain medical conditions.
2. Pneumococcal polysaccharide vaccine (PPSV): This vaccine also protects against Streptococcus pneumoniae, but it is recommended for adults 65 and older, as well as younger people with certain medical conditions.
3. Streptococcus pyogenes vaccine: This vaccine is being developed to protect against Group A Streptococcus (GAS), which can cause a variety of infections, including strep throat, skin infections, and serious diseases like rheumatic fever and toxic shock syndrome. There are several different GAS vaccine candidates in various stages of development.
4. Streptococcus agalactiae vaccine: This vaccine is being developed to protect against Group B Streptococcus (GBS), which can cause serious infections in newborns, pregnant women, and older adults with certain medical conditions. There are several different GBS vaccine candidates in various stages of development.
Overall, streptococcal vaccines play an important role in preventing bacterial infections and reducing the burden of disease caused by Streptococcus bacteria.
Scarlet Fever is a bacterial illness that mainly affects children and is characterized by a bright red rash on the body, high fever, and a sore throat. It's caused by Group A Streptococcus bacteria (Strep throat) and is treatable with antibiotics. The distinctive red rash associated with Scarlet Fever is due to toxins produced by the bacteria, which can also cause other symptoms such as flushed face, strawberry tongue, and a pale ring around the mouth. If left untreated, Scarlet Fever can lead to serious complications like kidney damage or rheumatic fever.
I'm sorry for any confusion, but "Oceanic Ancestry Group" is not a standard medical term or classification. It seems to be a general term that refers to people who have ancestral origins in the Oceanic region, which includes countries like Australia, New Zealand, and various islands in the Pacific Ocean.
In genetic or genealogical contexts, it might refer to a group of populations sharing certain genetic characteristics due to their geographical and historical connections. However, it's important to note that such classifications can be oversimplified and may not accurately reflect the complex genetic histories and cultural identities of individuals.
If you're looking for a medical term related to ancestry or genetics, you might be thinking of "racial" or "ethnic" categories, which are sometimes used in medical research or clinical settings to describe patterns of disease risk or treatment response. However, these categories are also flawed and can oversimplify the genetic and cultural diversity within and between populations. It's generally more useful and accurate to consider each individual's unique genetic and environmental factors when considering their health and medical needs.
Streptococcus is a genus of Gram-positive, spherical bacteria that typically form pairs or chains when clustered together. These bacteria are facultative anaerobes, meaning they can grow in the presence or absence of oxygen. They are non-motile and do not produce spores.
Streptococcus species are commonly found on the skin and mucous membranes of humans and animals. Some strains are part of the normal flora of the body, while others can cause a variety of infections, ranging from mild skin infections to severe and life-threatening diseases such as sepsis, meningitis, and toxic shock syndrome.
The pathogenicity of Streptococcus species depends on various virulence factors, including the production of enzymes and toxins that damage tissues and evade the host's immune response. One of the most well-known Streptococcus species is Streptococcus pyogenes, also known as group A streptococcus (GAS), which is responsible for a wide range of clinical manifestations, including pharyngitis (strep throat), impetigo, cellulitis, necrotizing fasciitis, and rheumatic fever.
It's important to note that the classification of Streptococcus species has evolved over time, with many former members now classified as different genera within the family Streptococcaceae. The current classification system is based on a combination of phenotypic characteristics (such as hemolysis patterns and sugar fermentation) and genotypic methods (such as 16S rRNA sequencing and multilocus sequence typing).
Bacterial antigens are substances found on the surface or produced by bacteria that can stimulate an immune response in a host organism. These antigens can be proteins, polysaccharides, teichoic acids, lipopolysaccharides, or other molecules that are recognized as foreign by the host's immune system.
When a bacterial antigen is encountered by the host's immune system, it triggers a series of responses aimed at eliminating the bacteria and preventing infection. The host's immune system recognizes the antigen as foreign through the use of specialized receptors called pattern recognition receptors (PRRs), which are found on various immune cells such as macrophages, dendritic cells, and neutrophils.
Once a bacterial antigen is recognized by the host's immune system, it can stimulate both the innate and adaptive immune responses. The innate immune response involves the activation of inflammatory pathways, the recruitment of immune cells to the site of infection, and the production of antimicrobial peptides.
The adaptive immune response, on the other hand, involves the activation of T cells and B cells, which are specific to the bacterial antigen. These cells can recognize and remember the antigen, allowing for a more rapid and effective response upon subsequent exposures.
Bacterial antigens are important in the development of vaccines, as they can be used to stimulate an immune response without causing disease. By identifying specific bacterial antigens that are associated with virulence or pathogenicity, researchers can develop vaccines that target these antigens and provide protection against infection.
Reactive arthritis is a form of inflammatory arthritis that occurs in response to an infection in another part of the body, such as the genitals, urinary tract, or gastrointestinal tract. It is also known as Reiter's syndrome. The symptoms of reactive arthritis include joint pain and swelling, typically affecting the knees, ankles, and feet; inflammation of the eyes, skin, and mucous membranes; and urethritis or cervicitis. It is more common in men than women and usually develops within 1-4 weeks after a bacterial infection. The diagnosis is made based on the symptoms, medical history, physical examination, and laboratory tests. Treatment typically includes antibiotics to eliminate the underlying infection and medications to manage the symptoms of arthritis.
Yellow fever is an acute viral hemorrhagic disease that's transmitted to humans through the bite of infected mosquitoes. The "yellow" in the name refers to the jaundice that can occur in some patients, resulting from liver damage caused by the virus. The disease is endemic in tropical regions of Africa and Central and South America.
The yellow fever virus is a single-stranded RNA virus that belongs to the Flaviviridae family, genus Flavivirus. It's closely related to other mosquito-borne viruses like dengue and Zika. The virus has three distinct geographical variants (West African, East African, and South American), each with different epidemiological patterns and clinical features.
The incubation period for yellow fever is typically 3 to 6 days after infection. The initial symptoms include fever, chills, headache, back pain, myalgia, and fatigue. Most patients recover after this initial phase, but around 15% of those infected enter a more severe phase characterized by high fever, jaundice, abdominal pain, vomiting, bleeding, and often rapid death within 7 to 10 days.
There is no specific treatment for yellow fever, and management is focused on supportive care, including fluid replacement, blood transfusions, and addressing any complications that arise. Prevention relies on vaccination and mosquito control measures. The yellow fever vaccine is safe and highly effective, providing immunity in 95% of those who receive it. A single dose offers lifelong protection in most individuals. Mosquito control efforts, such as reducing breeding sites and using insecticide-treated materials, can help prevent the spread of the virus in affected areas.
Mitral valve insufficiency, also known as mitral regurgitation, is a cardiac condition in which the mitral valve located between the left atrium and left ventricle of the heart does not close properly, causing blood to flow backward into the atrium during contraction of the ventricle. This leads to an increased volume load on the left heart chamber and can result in symptoms such as shortness of breath, fatigue, and fluid retention. The condition can be caused by various factors including valve damage due to degenerative changes, infective endocarditis, rheumatic heart disease, or trauma. Treatment options include medication, mitral valve repair, or replacement surgery depending on the severity and underlying cause of the insufficiency.
Typhoid fever is an acute illness caused by the bacterium Salmonella enterica serovar Typhi. It is characterized by sustained fever, headache, constipation or diarrhea, rose-colored rash (in some cases), abdominal pain, and weakness. The bacteria are spread through contaminated food, water, or direct contact with an infected person's feces. If left untreated, typhoid fever can lead to severe complications and even be fatal. It is diagnosed through blood, stool, or urine tests and treated with antibiotics. Vaccination is available for prevention.
I'm sorry for any confusion, but "New Caledonia" is not a medical term or concept. It is actually the name of a group of islands located in the southwest Pacific Ocean, east of Australia. The main island, Grande Terre, is known for its beautiful landscapes, which include mountains, beaches, and lagoons. New Caledonia is a special collectivity of France, and French is one of the official languages spoken there. If you have any questions related to medical terminology or health-related topics, I would be happy to help with those instead!
Adams-Stokes syndrome is a medical condition characterized by a series of episodes of sudden loss of consciousness (syncope) due to a significant decrease or temporary cessation of heart function (cardiac standstill or severe bradycardia). These episodes are often associated with convulsive movements and may be triggered by certain positions or activities that increase the obstruction to blood flow from the heart.
The syndrome is named after English physicians Robert Adams and William Stokes, who independently described the condition in the 19th century. It is most commonly caused by heart block or sick sinus syndrome, which are electrical conduction disorders of the heart. Other causes may include structural heart diseases, such as hypertrophic cardiomyopathy or coronary artery disease.
Treatment for Adams-Stokes syndrome typically involves addressing the underlying cause. In some cases, a pacemaker may be required to regulate the heart's electrical activity and prevent further episodes of syncope.
Aortic valve insufficiency, also known as aortic regurgitation or aortic incompetence, is a cardiac condition in which the aortic valve does not close properly during the contraction phase of the heart cycle. This allows blood to flow back into the left ventricle from the aorta, instead of being pumped out to the rest of the body. As a result, the left ventricle must work harder to maintain adequate cardiac output, which can lead to left ventricular enlargement and heart failure over time if left untreated.
The aortic valve is a trileaflet valve that lies between the left ventricle and the aorta. During systole (the contraction phase of the heart cycle), the aortic valve opens to allow blood to be pumped out of the left ventricle into the aorta and then distributed to the rest of the body. During diastole (the relaxation phase of the heart cycle), the aortic valve closes to prevent blood from flowing back into the left ventricle.
Aortic valve insufficiency can be caused by various conditions, including congenital heart defects, infective endocarditis, rheumatic heart disease, Marfan syndrome, and trauma. Symptoms of aortic valve insufficiency may include shortness of breath, fatigue, chest pain, palpitations, and edema (swelling). Diagnosis is typically made through physical examination, echocardiography, and other imaging studies. Treatment options depend on the severity of the condition and may include medication, surgery to repair or replace the aortic valve, or a combination of both.
Penicillins are a group of antibiotics derived from the Penicillium fungus. They are widely used to treat various bacterial infections due to their bactericidal activity, which means they kill bacteria by interfering with the synthesis of their cell walls. The first penicillin, benzylpenicillin (also known as penicillin G), was discovered in 1928 by Sir Alexander Fleming. Since then, numerous semi-synthetic penicillins have been developed to expand the spectrum of activity and stability against bacterial enzymes that can inactivate these drugs.
Penicillins are classified into several groups based on their chemical structure and spectrum of activity:
1. Natural Penicillins (e.g., benzylpenicillin, phenoxymethylpenicillin): These have a narrow spectrum of activity, mainly targeting Gram-positive bacteria such as streptococci and staphylococci. However, they are susceptible to degradation by beta-lactamase enzymes produced by some bacteria.
2. Penicillinase-resistant Penicillins (e.g., methicillin, oxacillin, nafcillin): These penicillins resist degradation by certain bacterial beta-lactamases and are primarily used to treat infections caused by staphylococci, including methicillin-susceptible Staphylococcus aureus (MSSA).
3. Aminopenicillins (e.g., ampicillin, amoxicillin): These penicillins have an extended spectrum of activity compared to natural penicillins, including some Gram-negative bacteria such as Escherichia coli and Haemophilus influenzae. However, they are still susceptible to degradation by many beta-lactamases.
4. Antipseudomonal Penicillins (e.g., carbenicillin, ticarcillin): These penicillins have activity against Pseudomonas aeruginosa and other Gram-negative bacteria with increased resistance to other antibiotics. They are often combined with beta-lactamase inhibitors such as clavulanate or tazobactam to protect them from degradation.
5. Extended-spectrum Penicillins (e.g., piperacillin): These penicillins have a broad spectrum of activity, including many Gram-positive and Gram-negative bacteria. They are often combined with beta-lactamase inhibitors to protect them from degradation.
Penicillins are generally well-tolerated antibiotics; however, they can cause allergic reactions in some individuals, ranging from mild skin rashes to life-threatening anaphylaxis. Cross-reactivity between different penicillin classes and other beta-lactam antibiotics (e.g., cephalosporins) is possible but varies depending on the specific drugs involved.
A heart murmur is an abnormal sound heard during a heartbeat, which is caused by turbulent blood flow through the heart. It is often described as a blowing, whooshing, or rasping noise. Heart murmurs can be innocent (harmless and not associated with any heart disease) or pathological (indicating an underlying heart condition). They are typically detected during routine physical examinations using a stethoscope. The classification of heart murmurs includes systolic, diastolic, continuous, and functional murmurs, based on the timing and auscultatory location. Various heart conditions, such as valvular disorders, congenital heart defects, or infections, can cause pathological heart murmurs. Further evaluation with diagnostic tests like echocardiography is often required to determine the underlying cause and appropriate treatment.
The International Council of Nurses (ICN) is not a medical organization, but rather a non-governmental organization that represents the nursing profession worldwide. Here's a medical definition-like description:
The International Council of Nurses (ICN) is a global federation of more than 130 national nurses' associations, representing the millions of nurses worldwide. Established in 1899, ICN is the international voice of nursing, advocating for quality health care, nursing education, evidence-based practice, and research. ICN sets standards, influences health policy, and promotes ethical nursing practice and the rights of nurses and patients. It works closely with other health organizations, including the World Health Organization (WHO), to promote global health and nursing concerns.
Mitral valve stenosis is a cardiac condition characterized by the narrowing or stiffening of the mitral valve, one of the four heart valves that regulate blood flow through the heart. This narrowing prevents the mitral valve from fully opening during diastole (relaxation phase of the heart cycle), leading to restricted flow of oxygenated blood from the left atrium into the left ventricle.
The narrowing or stiffening of the mitral valve can be caused by various factors, such as rheumatic heart disease, congenital heart defects, aging, or calcium deposits on the valve leaflets. As a result, the left atrium has to work harder to pump blood into the left ventricle, causing increased pressure in the left atrium and pulmonary veins. This can lead to symptoms such as shortness of breath, fatigue, coughing, and heart palpitations.
Mitral valve stenosis is typically diagnosed through a combination of medical history, physical examination, and imaging techniques like echocardiography or cardiac catheterization. Treatment options may include medications to manage symptoms and prevent complications, as well as surgical interventions such as mitral valve repair or replacement to alleviate the stenosis and improve heart function.
Glomerulonephritis is a medical condition that involves inflammation of the glomeruli, which are the tiny blood vessel clusters in the kidneys that filter waste and excess fluids from the blood. This inflammation can impair the kidney's ability to filter blood properly, leading to symptoms such as proteinuria (protein in the urine), hematuria (blood in the urine), edema (swelling), hypertension (high blood pressure), and eventually kidney failure.
Glomerulonephritis can be acute or chronic, and it may occur as a primary kidney disease or secondary to other medical conditions such as infections, autoimmune disorders, or vasculitis. The diagnosis of glomerulonephritis typically involves a combination of medical history, physical examination, urinalysis, blood tests, and imaging studies, with confirmation often requiring a kidney biopsy. Treatment depends on the underlying cause and severity of the disease but may include medications to suppress inflammation, control blood pressure, and manage symptoms.
Bacterial outer membrane proteins (OMPs) are a type of protein found in the outer membrane of gram-negative bacteria. The outer membrane is a unique characteristic of gram-negative bacteria, and it serves as a barrier that helps protect the bacterium from hostile environments. OMPs play a crucial role in maintaining the structural integrity and selective permeability of the outer membrane. They are involved in various functions such as nutrient uptake, transport, adhesion, and virulence factor secretion.
OMPs are typically composed of beta-barrel structures that span the bacterial outer membrane. These proteins can be classified into several groups based on their size, function, and structure. Some of the well-known OMP families include porins, autotransporters, and two-partner secretion systems.
Porins are the most abundant type of OMPs and form water-filled channels that allow the passive diffusion of small molecules, ions, and nutrients across the outer membrane. Autotransporters are a diverse group of OMPs that play a role in bacterial pathogenesis by secreting virulence factors or acting as adhesins. Two-partner secretion systems involve the cooperation between two proteins to transport effector molecules across the outer membrane.
Understanding the structure and function of bacterial OMPs is essential for developing new antibiotics and therapies that target gram-negative bacteria, which are often resistant to conventional treatments.
The mitral valve, also known as the bicuspid valve, is a two-leaflet valve located between the left atrium and left ventricle in the heart. Its function is to ensure unidirectional flow of blood from the left atrium into the left ventricle during the cardiac cycle. The mitral valve consists of two leaflets (anterior and posterior), the chordae tendineae, papillary muscles, and the left atrial and ventricular myocardium. Dysfunction of the mitral valve can lead to various heart conditions such as mitral regurgitation or mitral stenosis.
Fever of Unknown Origin (FUO) is a medical condition defined as a fever that remains undiagnosed after one week of inpatient evaluation or three days of outpatient evaluation, with temperatures repeatedly measuring at or above 38.3°C (101°F). The fevers can be continuous or intermittent and are often associated with symptoms such as fatigue, weight loss, and general malaise.
The causes of FUO can be broadly categorized into four groups: infections, inflammatory diseases, neoplasms (cancers), and miscellaneous conditions. Infections account for a significant proportion of cases, particularly in immunocompromised individuals. Other possible causes include connective tissue disorders, vasculitides, drug reactions, and factitious fever.
The diagnostic approach to FUO involves a thorough history and physical examination, laboratory tests, and imaging studies. The goal is to identify the underlying cause of the fever and provide appropriate treatment. In some cases, despite extensive evaluation, the cause may remain undiagnosed, and management focuses on supportive care and monitoring for any new symptoms or complications.
Arthritis is a medical condition characterized by inflammation in one or more joints, leading to symptoms such as pain, stiffness, swelling, and reduced range of motion. There are many different types of arthritis, including osteoarthritis, rheumatoid arthritis, psoriatic arthritis, gout, and lupus, among others.
Osteoarthritis is the most common form of arthritis and is caused by wear and tear on the joints over time. Rheumatoid arthritis, on the other hand, is an autoimmune disorder in which the body's immune system mistakenly attacks the joint lining, causing inflammation and damage.
Arthritis can affect people of all ages, including children, although it is more common in older adults. Treatment for arthritis may include medications to manage pain and reduce inflammation, physical therapy, exercise, and in some cases, surgery.
Bacterial antibodies are a type of antibodies produced by the immune system in response to an infection caused by bacteria. These antibodies are proteins that recognize and bind to specific antigens on the surface of the bacterial cells, marking them for destruction by other immune cells. Bacterial antibodies can be classified into several types based on their structure and function, including IgG, IgM, IgA, and IgE. They play a crucial role in the body's defense against bacterial infections and provide immunity to future infections with the same bacteria.
An encyclopedia is a comprehensive reference work containing articles on various topics, usually arranged in alphabetical order. In the context of medicine, a medical encyclopedia is a collection of articles that provide information about a wide range of medical topics, including diseases and conditions, treatments, tests, procedures, and anatomy and physiology. Medical encyclopedias may be published in print or electronic formats and are often used as a starting point for researching medical topics. They can provide reliable and accurate information on medical subjects, making them useful resources for healthcare professionals, students, and patients alike. Some well-known examples of medical encyclopedias include the Merck Manual and the Stedman's Medical Dictionary.
Rheumatic fever
Complication (medicine)
Sequela
Autoimmune disease
District nurse
Blis Technologies
Thomas King Chambers
Charles K. Friedberg
House of the Good Samaritan
Beth Robinson
History of aspirin
Willow
Eric John Holborow
Child poverty in New Zealand
Scarlet fever
Alvan Feinstein
William Dennison Clark
Shane Fenton and the Fentones
Leopold Lichtwitz
Hector Macpherson (astronomer)
Tonya Williams
Group A streptococcal infection
Anitschkow cell
University of Auckland Faculty of Medical and Health Sciences
German Center for Pediatric and Adolescent Rheumatology
Lois Fernandez
Benzathine benzylpenicillin
Albert Dorfman
Adele C. Howells
La Rabida Children's Hospital
Rheumatic Fever: All You Need to Know | CDC
Rheumatic fever - Wikipedia
Rheumatic Fever | Encyclopedia.com
Rheumatic Fever: Background, Pathophysiology, Epidemiology
Rheumatic fever: Causes, symptoms, and treatment
Pediatric Rheumatic Fever
Acute Rheumatic Fever | Johns Hopkins Medicine
Rheumatic fever - Diagnosis and treatment - Mayo Clinic
Rheumatic Fever in Emergency Medicine: Practice Essentials, Background, Pathophysiology
Rheumatic Fever Workup: Laboratory Studies, Imaging Studies, Other Tests
Rheumatic Fever and the Heart | HealthLink BC
rheumatic fever - definition and meaning
Pilot Program to Prevent Rheumatic Fever | Abt Associates
Funding for rheumatic fever prevention halved in Budget despite failure to cut hospitalisations - NZ Herald
M-Protein Analysis of Streptococcus pyogenes Isolates Associated with Acute Rheumatic Fever in New Zealand
Rheumatic fever - treat the cause « The Standard
Rheumatic Fever - Pediatrics - Merck Manuals Professional Edition
Rheumatic fever » Te Whatu Ora Health New Zealand Waikato
Long-term outcome of patients with rheumatic fever receiving benzathine penicillin G prophylaxis every three weeks versus every...
rheumatic fever - Tom Monte
Pediatric Rheumatic Fever Clinical Presentation: History, Physical Examination
Rheumatic Fever - DR. TANYA ALTMANN
Concomitant rheumatic fever and dilated cardiomyopathy: a case report | Pediatric Oncall Journal
A guide for the use of echocardiography in acute rheumatic fever - Algorithm - Heart Foundation
Streptococcal Mechanisms: Novel Models and New Insights into Acute Rheumatic Fever and Rheumatic Heart Disease - RHD Congress
Rheumatic fever - Te Whatu Ora - Health New Zealand
Acute53
- McDonald M, Currie BJ, Carapetis JR. Acute rheumatic fever: a chink in the chain that links the heart to the throat? (medscape.com)
- Acute rheumatic fever. (medscape.com)
- Group A streptococcal isolates temporally associated with acute rheumatic fever in Hawaii: differences from the continental United States. (medscape.com)
- Resurgence of acute rheumatic fever in the intermountain area of the United States. (medscape.com)
- The return of acute rheumatic fever in young adults. (medscape.com)
- Acute rheumatic fever in American Samoa. (medscape.com)
- If you or your child is diagnosed with acute rheumatic fever, you or your child will be treated with antibiotics. (medlineplus.gov)
- To help manage swelling of inflamed tissues during acute rheumatic fever, medicines such as aspirin or corticosteroids may be needed. (medlineplus.gov)
- Acute rheumatic fever is a nonsuppurative, immune-mediated consequence of group A streptococcal pharyngitis (strep throat). (cdc.gov)
- Antibiotics can prevent acute rheumatic fever if administered no more than 9 days after symptom onset. (cdc.gov)
- 49% of those with acute rheumatic fever subsequently received a diagnosis of rheumatic heart disease. (cdc.gov)
- Noncompliance with recommended prophylaxis with BPG after physician-diagnosed acute rheumatic fever was noted for 22 (34%) of 65 patients. (cdc.gov)
- Establishment of a coordinated acute rheumatic fever and rheumatic heart disease control program in American Samoa, likely would improve diagnosis, treatment, and patient compliance with BPG prophylaxis. (cdc.gov)
- Acute rheumatic fever occurs most commonly among children aged 5-15 years. (cdc.gov)
- Pediatric cases of acute rheumatic fever and rheumatic heart disease were defined as physician-diagnosed acute rheumatic fever or rheumatic heart disease among patients aged ≤18 years who had sought care during 2011-2012 at the hospital in American Samoa. (cdc.gov)
- International Classification of Diseases, Ninth Revision (ICD-9) codes and BPG prophylaxis registries including patients currently receiving BPG treatment at the hospital were used to identify cases of acute rheumatic fever and rheumatic heart disease during 2011-2012 and to estimate the August 2013 point prevalence of rheumatic heart disease. (cdc.gov)
- In addition, hospital patient registries for BPG prophylaxis were reviewed to identify additional acute rheumatic fever and rheumatic heart disease patients. (cdc.gov)
- Medical records for all identified patients were reviewed to verify acute rheumatic fever or rheumatic heart disease diagnoses and BPG prophylaxis noncompliance, which included recorded missed or late doses. (cdc.gov)
- Acute rheumatic fever incidence (2011-2012) and rheumatic heart disease point prevalence (August 2013) were calculated by using 2010 U.S. Census Bureau data (American Samoa pop. (cdc.gov)
- Acute rheumatic fever incidence was 1.1 and 1.5 cases per 1,000 children, for 2011 and 2012, respectively. (cdc.gov)
- tor of acute rheumatic fever (ARF). (cdc.gov)
- Acute rheumatic fever is a common and were obtained and where further informa- serious public health problem in developing tion was needed the patient was clinically countries [ 1,2 ]. (who.int)
- Diagnosis of industrialized and developing countries [ 3- acute rheumatic fever was based on the 6 ]. (who.int)
- Acute rheumatic fever (ARF) and its chronic sequela, rheumatic heart disease (RHD), have become rare in most affluent populations, but remain unchecked in developing countries and in some poor, mainly indigenous populations in wealthy countries. (nih.gov)
- Cardiac Myosin Epitopes Recognized by Autoantibody in Acute and Convalescent Rheumatic Fever. (medscape.com)
- Bhatia S, Tariq A. Characteristics and Temporal Trends of Patients Diagnosed with Acute Rheumatic Fever in the United States from 2001-2011. (medscape.com)
- Lahiri S, Sanyahumbi A. Acute rheumatic fever. (medscape.com)
- Orün UA, Ceylan O, Bilici M, Karademir S, Ocal B, Senocak F. Acute rheumatic fever in the Central Anatolia Region of Turkey: a 30-year experience in a single center. (medscape.com)
- The worldwide epidemiology of acute rheumatic fever and rheumatic heart disease. (medscape.com)
- Revision of the Jones Criteria for the diagnosis of acute rheumatic fever in the era of Doppler echocardiography: a scientific statement from the American Heart Association. (medscape.com)
- Prevention of Acute Rheumatic Fever is a national health priority in New Zealand where rates are much higher than other developing countries, particularly in Māori and Pacific children. (heartfoundation.org.nz)
- Acute gastric ulcer in a boy with allergic urticaria and rheumatic fever treated with salicylates]. (nih.gov)
- Group A streptococcal (GAS) pharyngitis is the etiologic precursor of acute rheumatic fever, but host and environmental factors are important. (msdmanuals.com)
- Acute rheumatic fever is prevalent across the world and carries a high mortality and morbidity predominantly due to its complication of carditis. (longdom.org)
- Acute Rheumatic Fever (ARF) is an auto-immune consequence of infection with the bacterium Group A streptococcus (GAS), characterized by a sub-acute generalized inflammatory response particularly affecting the heart, joints, brain and skin. (longdom.org)
- The minor criteria include arthralgia (counted only when arthritis is not present), fever, elevated acute phase reactants and an electrocardiogram showing a prolonged PR interval. (longdom.org)
- Zeiger, Roni F.. "Acute Rheumatic Fever. (unboundmedicine.com)
- Medicine Central , im.unboundmedicine.com/medicine/view/Diagnosaurus/114591/all/Acute_rheumatic_fever. (unboundmedicine.com)
- Erythema marginatum, the characteristic rash of acute rheumatic fever, is shown below. (medscape.com)
- Clinical manifestations and time course of acute rheumatic fever are shown in the image below. (medscape.com)
- Clinical manifestations and time course of acute rheumatic fever. (medscape.com)
- After an incubation period of 2-4 days, the invading organisms elicit an acute inflammatory response, with 3-5 days of sore throat, fever, malaise, headache, and elevated leukocyte count. (medscape.com)
- GABHS organisms also may be associated with nonsuppurative diseases (eg, rheumatic fever, acute poststreptococcal glomerulonephritis). (medscape.com)
- Acute rheumatic fever (ARF) is an autoimmune, inflammatory response to infection with group A Streptococcus (GAS) that affects multiple organ systems. (unboundmedicine.com)
- Research led by the University of Otago in New Zealand has uncovered the strongest evidence yet that household overcrowding is a major risk factor for acute rheumatic fever and streptococcal infections of the skin. (thincb2b.com)
- Rheumatic heart disease (RHD) caused by acute rheumatic fever (ARF) is a disease of poverty, poor hygiene and poor living standards. (nt.gov.au)
- The NSW Rheumatic Heart Disease (RHD) Register helps people with acute rheumatic fever (ARF) and RHD stick to treatment. (nsw.gov.au)
- While we provide symptomatic relief for viral pharyngitis, the popular dogma is that treating strep pharyngitis with a course of antibiotics is will hasten recovery and prevent the incidence of acute rheumatic fever (ARF) and rheumatic heart disease (RHD). (emdocs.net)
- If acute rheumatic fever is a concern, why not just treat everyone? (emdocs.net)
- Minor criteria include fever, joint pain, elevated acute phase reactants (such as C-reactive protein), and prolonged PR interval on electrocardiogram. (cims.org)
- RHD is a result of damage to the heart valves after acute rheumatic fever (ARF). (childrensnational.org)
- The initial damage is called acute rheumatic fever. (childrensnational.org)
- Descriptive analysis of group A Streptococcus in skin swabs and acute rheumatic fever, Auckland, New Zealand, 2010-2016. (otago.ac.nz)
Established rheumatic heart d1
- Many patients are seen recommendations of the American Society with established rheumatic heart disease at of Echocardiography. (who.int)
Risk of developing rheu3
- Treating people who have strep throat with antibiotics, such as penicillin, decreases the risk of developing rheumatic fever. (wikipedia.org)
- Poorly treated or recurrent streptococcal infections increase the risk of developing rheumatic fever. (cims.org)
- 1. Age: Children between the ages of 5 and 15 are at the highest risk of developing rheumatic fever, although it can occur at any age. (cims.org)
Cause rheumatic fever5
- Without treatment, some sore throats can cause rheumatic fever which can lead to heart damage. (kidshealth.org.nz)
- To stop your child from getting strep throat, which can cause rheumatic fever again, make sure they have regular penicillin injections. (kidshealth.org.nz)
- However, epidemiological associations in certain populations have led to speculation that group A Streptococcus impetigo could predispose to or cause rheumatic fever as well. (medscape.com)
- Lead researcher Professor Michael Baker of the University of Otago, Wellington, says it is the first time researchers have investigated risk factors for Group A streptococcal infections of the throat (strep throat) and skin (strep skin) that can cause rheumatic fever. (thincb2b.com)
- This is the bacteria that cause rheumatic fever (RF) and strep throat . (medlineplus.gov)
Prevent rheumatic fever4
- The goal of these medicines is to prevent rheumatic fever from recurring. (medlineplus.gov)
- Penicillin is the best antibiotic to prevent rheumatic fever. (kidshealth.org.nz)
- The best way to prevent rheumatic fever is to make sure your child has regular penicillin injections on time. (kidshealth.org.nz)
- Find out how to prevent rheumatic fever and how important it is to prevent your child from getting it again. (kidshealth.org.nz)
Living with rheumatic heart d1
- Case-finding using hospital BPG prophylaxis registries was conducted to determine the number of children known to be living with rheumatic heart disease at the time of the study. (cdc.gov)
Known as rheumatic heart d2
- Damage to the heart valves, known as rheumatic heart disease (RHD), usually occurs after repeated attacks but can sometimes occur after one. (wikipedia.org)
- This is known as rheumatic heart disease and can lead to abnormal heart rhythms or heart failure. (sesamecare.com)
History of rheumatic fever4
- People with a history of rheumatic fever are at high risk of recurrent attacks of rheumatic fever and developing rheumatic heart disease following a streptococcal throat infection. (cochrane.org)
- The likelihood of developing rheumatic fever appears to be linked to various risk factors such as a family history of rheumatic fever, the strain of strep bacteria responsible for the infection and a weakened immune system prior to contracting strep throat. (internal-medicine-centers.com)
- The studies found that both rheumatic fever and strep skin were linked with barriers to accessing primary health care and a family history of rheumatic fever and rheumatic heart disease, a serious illness which can develop if rheumatic fever is untreated. (thincb2b.com)
- Example: Certain families may have a history of rheumatic fever, indicating a genetic influence on the susceptibility to the disease. (cims.org)
Recurrence of rheumatic fever2
- You or your child may need an extended course of antibiotics to help prevent the recurrence of rheumatic fever. (internal-medicine-centers.com)
- Preventative antibiotic medication may be prescribed for long-term use to protect against a recurrence of rheumatic fever. (sesamecare.com)
Infection26
- Rheumatic fever may occur following an infection of the throat by the bacterium Streptococcus pyogenes. (wikipedia.org)
- If the infection is left untreated, rheumatic fever occurs in up to three percent of people. (wikipedia.org)
- Rheumatic fever is a systemic disease affecting the connective tissue around arterioles, and can occur after an untreated strep throat infection, specifically due to group A streptococcus (GAS), Streptococcus pyogenes. (wikipedia.org)
- Rheumatic fever is a disease that may develop after an infection with group A streptococcus bacteria (such as strep throat or scarlet fever ). (medlineplus.gov)
- Streptococcal skin infection and rheumatic heart disease. (medscape.com)
- Rheumatic fever is an entirely preventable childhood infection, caused by the body's immune response to a streptococcal infection of the throat. (heartfoundation.org.nz)
- Rheumatic fever is a rare complication of throat infection, that can damage the heart. (cochrane.org)
- People who have had rheumatic fever can suffer from it again following streptococcal throat infection if they do not receive regular penicillin. (cochrane.org)
- To assess the effects of penicillin compared to placebo and the effects of different penicillin regimens and formulations for preventing streptococcal infection and rheumatic fever recurrence. (cochrane.org)
- Only one of three studies showed that penicillin reduced rheumatic fever recurrence (RR 0.45, 95% CI 0.22 to 0.92) and streptococcal throat infection (RR 0.84, 95% CI 0.72 to 0.97). (cochrane.org)
- Rheumatic fever is an inflammatory disease which follows infection with Lancefield group A streptococci, affecting the heart, skin, joints and central nervous system. (gpnotebook.com)
- Supporting evidence to confirm streptococcal infection includes increased antistreptolysin-O or other streptococcal antibodies, throat culture positive for group A streptococcus, or recent scarlet fever. (cdc.gov)
- The absence of supporting evidence of preceding streptococcal infection should make the diagnosis doubtful, except in Sydenham chorea or low-grade carditis when rheumatic fever is first discovered after a long latent period from the antecedent infection. (cdc.gov)
- Typically developing 2-4 weeks after a strep throat infection, rheumatic fever symptoms can vary but may last anywhere from several months to years. (internal-medicine-centers.com)
- The best way to ensure you or your child do not develop rheumatic fever is to quickly treat a strep throat infection through antibiotic therapy to eradicate the group A streptococcus bacteria. (internal-medicine-centers.com)
- The symptoms of rheumatic fever usually develop one to five weeks after a streptococcal throat infection. (zana.com)
- Upon the streptococcal infection until the emergence of symptoms of rheumatic polyarthritis, a long latent period must pass, which usually lasts from one up until 4 weeks. (zana.com)
- Tick-borne relapsing fever (TBRF) is a bacterial infection spread by ticks. (familydoctor.org)
- In a small percent of patients, infection leads to rheumatic fever several weeks after the sore throat has resolved. (medscape.com)
- Finding a strong association between skin infection and rheumatic fever adds to evidence from other research conducted by our group about the importance of strep skin in triggering this disease. (thincb2b.com)
- Rheumatic fever is an inflammatory reaction to group A Streptococcus bacterial infection of the throat and skin. (thincb2b.com)
- This inflammation occurs as an overreaction to an infection from the Group A streptococcus bacteria - the pathogen that causes strep throat and scarlet fever. (sesamecare.com)
- When these conditions go untreated or incompletely treated (for instance, if a course of antibiotics goes unfinished), the infection may progress into rheumatic fever. (sesamecare.com)
- Rheumatic fever is an inflammatory disease that can occur after a group A streptococcal infection, such as strep throat. (cims.org)
- Rheumatic fever is classified based on the Jones criteria, which consider major and minor clinical manifestations, along with evidence of a recent streptococcal infection. (cims.org)
- A diagnosis of rheumatic fever requires evidence of recent streptococcal infection plus either two major criteria or one major and two minor criteria. (cims.org)
Trigger rheumatic fever2
- Strep infections that involve other parts of the body do not seem to trigger rheumatic fever. (medlineplus.gov)
- Penicillin kills the strep bacteria that trigger rheumatic fever, stopping any further damage to your child's heart valves. (kidshealth.org.nz)
Diagnose rheumatic fever2
- Several factors called major and minor criteria have been developed to help diagnose rheumatic fever in a standard way. (medlineplus.gov)
- There is no single test which can be used to diagnose rheumatic fever. (internal-medicine-centers.com)
Previous rheumatic fever1
- Randomised and quasi-randomised studies comparing (i) penicillin with control, (ii) oral with intramuscular penicillin (iii) 2- or 3-weekly with 4-weekly intramuscular penicillin in patients with previous rheumatic fever. (cochrane.org)
Antibiotics4
- In those with rheumatic fever and rheumatic heart disease, prolonged periods of antibiotics are sometimes recommended. (wikipedia.org)
- If you or your child had heart problems when the rheumatic fever occurred, antibiotics may be needed for even longer, perhaps for life. (medlineplus.gov)
- Studies in the 1950s during an epidemic on a military base demonstrated 3% incidence of rheumatic fever in adults with streptococcal pharyngitis not treated with antibiotics. (medscape.com)
- Taking antibiotics for onset of rheumatic fever or gum disease could prevent developing either heart condition. (uky.edu)
Illness7
- When I was ten and going to school my father had a bad illness- rheumatic fever . (dictionary.com)
- Rheumatic fever is a serious illness. (kidshealth.org.nz)
- Rheumatic fever is a serious illness that can cause damage in your child's heart as well as swelling and pain in their hips, knees, ankles, elbows, and wrists. (kidshealth.org.nz)
- Most of the long-term effects of rheumatic fever are cardiovascular in nature and may not begin until years after the illness. (internal-medicine-centers.com)
- Rheumatic fever (RF) is a systemic illness that may occur following group A beta hemolytic streptococcal (GABHS) pharyngitis in children. (medscape.com)
- Scarlet fever - an illness that follows strep throat. (nih.gov)
- Other conditions are the result of a childhood illness such as rheumatic fever. (ohsu.edu)
Symptoms11
- Signs and symptoms include fever, multiple painful joints, involuntary muscle movements, and occasionally a characteristic non-itchy rash known as erythema marginatum. (wikipedia.org)
- The disease is so named because its symptoms are similar to those of some rheumatic disorders. (wikipedia.org)
- However the antibodies may also react against the myocardium and joints, producing the symptoms of rheumatic fever. (wikipedia.org)
- Contact your provider if you or your child develops symptoms of rheumatic fever. (medlineplus.gov)
- Due to the dangers of rheumatic fever, children or adults who experience any of the above-mentioned symptoms, or anyone who experiences strep throat symptoms , should receive immediate guidance from a healthcare professional to avoid complications. (internal-medicine-centers.com)
- If you or your child are presenting with rheumatic fever symptoms, your healthcare provider will conduct a physical examination, review your medical history and reported symptoms, and may elect to conduct various tests including a blood test, electrocardiogram (EKG) or echocardiogram. (internal-medicine-centers.com)
- The most common forms of rheumatic polyarthritis are not the severe cases which involve a high fever and especially pronounced articular symptoms. (zana.com)
- Common symptoms of rheumatic fever are described below. (zana.com)
- If signs or symptoms of rheumatic fever are present (such as joint pain), seek medical attention immediately. (sesamecare.com)
- Incomplete treatment can result in the symptoms of rheumatic fever coming back. (sesamecare.com)
- 3. Cardiac Symptoms: Rheumatic fever can cause inflammation of the heart, leading to symptoms such as chest pain, shortness of breath, rapid or irregular heartbeat, and fatigue. (cims.org)
People who have had rheumatic2
- With proper care and regular penicillin injections, most people who have had rheumatic fever lead a normal life. (kidshealth.org.nz)
- This disease is more common in people who have had rheumatic heart disease. (lahey.org)
Incidence2
- Breda L, Marzetti V, Gaspari S, Del Torto M, Chiarelli F, Altobelli E. Population-based study of incidence and clinical characteristics of rheumatic Fever in abruzzo, central Italy, 2000-2009. (medscape.com)
- The Heart Foundation welcomes this week's announcement by the Associate Minister of Health Jenny Salesa that the Government's Wellbeing Budget will include $12 million to reduce the incidence of rheumatic fever amongst Māori and Pacific people. (heartfoundation.org.nz)
Sore2
- Rheumatic fever often starts with a sore throat caused by strep bacteria. (kidshealth.org.nz)
- Watch animated videos to find out about sore throats, rheumatic fever and the importance of keeping a healthy heart. (kidshealth.org.nz)
ABSTRACT Rheumatic1
- ABSTRACT Rheumatic fever remains a significant health problem in Jordan. (who.int)
Carditis3
- Group G Streptococcus Induces an Autoimmune Carditis Mediated by Interleukin 17A and Interferon γ in the Lewis Rat Model of Rheumatic Heart Disease. (medscape.com)
- Inflammation of the heart (carditis) is another common and potentially serious symptom of rheumatic fever. (zana.com)
- Carditis occurs in an estimated 30-60% of people with rheumatic fever and is more common in younger children. (zana.com)
Chorea3
- Around in one in four children with rheumatic fever will develop Sydenham's chorea, but it is rare in adults. (zana.com)
- Sydenham used this term in his Schedula Monitoria to describe rheumatic chorea in 1686. (medscape.com)
- For example, untreated Group A Streptococcus ( S. pyogenes ) infections cause autoimmune sequela in many target tissues such as the heart or CNS, manifested as either rheumatic fever or Sydenham's chorea (SC), respectively ( 6 - 8 ). (frontiersin.org)
Diagnosis2
- Guideline] Guidelines for the diagnosis of rheumatic fever. (medscape.com)
- Jones criteria (revised) for guidance in the diagnosis of rheumatic fever. (cdc.gov)
Scarlet fever6
- This abnormal reaction seems to almost always occur with strep throat or scarlet fever. (medlineplus.gov)
- Rheumatic fever mainly affects children ages 5 to 15 who have had strep throat or scarlet fever. (medlineplus.gov)
- Rheumatic fever is a relatively serious inflammatory disease which can result due to complications from strep throat or scarlet fever. (internal-medicine-centers.com)
- With the potential to cause irreversible damage to the heart, and the increased likelihood of experiencing a stroke or death, it is important to seek medical attention for both rheumatic fever and for strep throat or scarlet fever (to prevent rheumatic fever's development). (internal-medicine-centers.com)
- Rheumatic fever is caused by a bacterium called group A streptococcus, the same bacterium responsible for strep throat and scarlet fever. (internal-medicine-centers.com)
- In other cases, patients will suffer from other focal infections such as dental granulomas or abscesses, otitis, paradontosis, sinusitis, or other diseases where Streptococcus is involved such as scarlet fever, etc. (zana.com)
Antibiotic2
- Rheumatic fever treatment will first focus on eliminating the group A streptococcus bacteria through the use of penicillin or other antibiotic. (internal-medicine-centers.com)
- To treat rheumatic fever, your doctor will prescribe a course of antibiotic medication (usually penicillin). (sesamecare.com)
Attacks4
- Reaching Toronto, I learned that my eldest son was at death's door from repeated attacks of rheumatic fever . (dictionary.com)
- Giving penicillin to these people can prevent recurrent attacks of rheumatic fever and subsequent rheumatic heart disease. (cochrane.org)
- Cardiac involvement is reported to occur in 30-70% of patients with their first attack of rheumatic fever and in 73-90% of patients when all attacks are counted. (medscape.com)
- One or more attacks of rheumatic fever can cause permanent damage to heart valves resulting in rheumatic heart disease which may require major surgery, and can result in a lower quality of life and premature death. (thincb2b.com)
Nonsuppurative1
- Shulman ST, Jaggi P. Nonsuppurative poststreptococcal sequelae: rheumatic fever and glomerulonephritis. (medlineplus.gov)
Inflammatory disease2
- Rheumatic fever (RF) is an inflammatory disease that can involve the heart, joints, skin, and brain. (wikipedia.org)
- Rheumatic fever is a rare inflammatory disease. (familydoctor.org)
Indigenous Australian Children3
- Paruby MG, Carapetis JR. Rheumatic fever in Indigenous Australian Children. (medscape.com)
- DoH Digital Library: Rheumatic fever in indigenous Australian children. (nt.gov.au)
- Rheumatic fever in indigenous Australian children. (nt.gov.au)
Subsequent3
- Undernutrition, overcrowding, and lower socioeconomic status predispose to streptococcal infections and subsequent episodes of rheumatic fever. (msdmanuals.com)
- It would be useful to conduct suitable trials to see how better accessto effective treatment of skin infections could be delivered most effectively and how this could lower the subsequent risk of rheumatic fever. (thincb2b.com)
- 2. Socioeconomic Factors: Factors such as overcrowding, poor sanitation, and limited access to healthcare facilities can contribute to an increased risk of streptococcal infections and subsequent rheumatic fever. (cims.org)
Pharyngitis2
- Patients who have had rheumatic fever have about a 50% likelihood of having a recurrence if they have another episode of group A streptococcal pharyngitis that is untreated. (msdmanuals.com)
- Rheumatic fever develops in children and adolescents following pharyngitis with GABHS (ie, Streptococcus pyogenes ). (medscape.com)
Chronic3
- Preven- tion of chronic rheumatic heart disease is · length of the colour jet 1 cm. feasible and cost effective if secondary prophylaxis is started and maintained regu- larly [ 11,12 ]. (who.int)
- The developmental origins of chronic rheumatic heart disease. (medscape.com)
- Untreated ARF can lead to chronic rheumatic heart disease (RHD). (unboundmedicine.com)
Streptococcus1
- Rheumatic fever occurs after infections with a germ or bacteria called Streptococcus pyogenes or group A streptococcus. (medlineplus.gov)
Recurrent1
- Fortunately, the recently announced National Rheumatic Fever Strategy, comprising recurrent funding to the Northern Territory, Queensland and Western Australia for control programmes, as well as the creation of a National Coordination Unit suggest that RHD control in Australia is now a tangible prospect. (nt.gov.au)
Heart valves4
- If rheumatic fever damages the heart valves, this is called rheumatic heart disease. (kidshealth.org.nz)
- What if rheumatic heart disease causes leaky heart valves? (kidshealth.org.nz)
- Not everyone with rheumatic fever will have heart valve damage, but people with badly damaged heart valves may need heart surgery. (kidshealth.org.nz)
- 1. Cardiac Rheumatic Fever: In this type, the heart is primarily affected, leading to inflammation of the heart valves (valvulitis), which can cause long-term damage and result in heart murmurs, heart failure, or other cardiac complications. (cims.org)
Bacteria2
- It's tied to the bacteria that… What is rheumatic fever? (familydoctor.org)
- Rheumatic fever is caused by an immune response to group A streptococcal bacteria. (cims.org)
20211
- The global infant fever stickers market revenue was around US$ 390.1 million in 2021 and is estimated to reach US$ 860.3 million by 2031, growing at a compound annual growth rate (CAGR) of 8.3% during the forecast period from 2022 to 2031. (openpr.com)
Autoimmune2
- Guilherme L, Kalil J, Cunningham M. Molecular mimicry in the autoimmune pathogenesis of rheumatic heart disease. (medscape.com)
- Guilherme L, Kalil J. Rheumatic Heart Disease: Molecules Involved in Valve Tissue Inflammation Leading to the Autoimmune Process and Anti-S. pyogenes Vaccine. (medscape.com)
Cardiac3
- The organization cared for Ebola patients in Sierra Leone and, at the Salam Center for Cardiac Surgery in Khartoum, Sudan, children whose hearts were damaged by rheumatic fever . (dictionary.com)
- The significance of rheumatic fever is almost solely due to its cardiac sequel. (longdom.org)
- Cardiac involvement leads to Rheumatic Heart Disease (RHD). (longdom.org)
20231
- Chapter 13: Global Infant Fever Stickers market Size Forecast (2023-2031). (openpr.com)
Severe1
- Rheumatic fever can cause severe heart problems and heart damage. (medlineplus.gov)
Occurs1
- Rheumatic fever occurs in about 325,000 children each year and about 33.4 million people currently have rheumatic heart disease. (wikipedia.org)
Regurgitation1
- Untreated gum infections and rheumatic fever could lead to stenosis or regurgitation later in life. (uky.edu)
Occur1
- When rheumatic fever does occur in the United States, it is most often in small outbreaks. (medlineplus.gov)
20182
- According to Ministry of Health figures, there were 171 recorded cases of rheumatic fever in 2018, two thirds of whom were aged under 14 years. (heartfoundation.org.nz)
- In 2018 the World Health Organization issued a referendum recognizing rheumatic heart disease as an important disease that member states and ministries of health need to prioritize in their public health efforts. (childrensnational.org)
Aspirin1
- Aspirin, ibuprofen or naproxen may be recommended to reduce fever, joint pain and inflammation. (internal-medicine-centers.com)
American Samoa1
- The heart screening is made possible by American Samoa Department of Health partnering with BYU (Brigham Young University) Rheumatic Relief and The Church of Jesus Christ of Latter-day Saints. (churchofjesuschrist.org)
Joints3
- It is marked by fever and inflammation of the joints, nerves, and heart, where it can progress to scarring and permanent dysfunction of the valves. (dictionary.com)
- Pain and swelling of the joints ( Arthritis ) is the most common symptom of rheumatic fever, affecting three out offour people. (zana.com)
- 2. Joint Rheumatic Fever: Joint involvement is a characteristic feature of rheumatic fever, resulting in painful, swollen, and inflamed joints. (cims.org)
Common symptom1
- 2. Fever: High-grade fever, often accompanied by chills and sweating, is a common symptom. (cims.org)
Erythema marginatum1
- Around 1 in 10 children with rheumatic fever will develop a skin rash, known as erythema marginatum. (zana.com)
Complications1
- Regular heart exams are important throughout the life of a person who has had rheumatic fever to ensure no complications have developed, and, if they have, proper treatment is administered. (internal-medicine-centers.com)