An idiopathic systemic inflammatory granulomatous disorder comprised of epithelioid and multinucleated giant cells with little necrosis. It usually invades the lungs with fibrosis and may also involve lymph nodes, skin, liver, spleen, eyes, phalangeal bones, and parotid glands.
Sarcoidosis affecting predominantly the lungs, the site most frequently involved and most commonly causing morbidity and mortality in sarcoidosis. Pulmonary sarcoidosis is characterized by sharply circumscribed granulomas in the alveolar, bronchial, and vascular walls, composed of tightly packed cells derived from the mononuclear phagocyte system. The clinical symptoms when present are dyspnea upon exertion, nonproductive cough, and wheezing. (Cecil Textbook of Medicine, 19th ed, p431)
Intradermal injection of a heated (pasteurized) saline suspension of sarcoid tissue obtained from a sarcoid spleen or lymph node. In patients with active sarcoidosis a dusky red nodule develops slowly over the next few weeks at the injection site. Histologic examination, an essential part of the complete test, reveals sarcoid tissue.
A relatively small nodular inflammatory lesion containing grouped mononuclear phagocytes, caused by infectious and noninfectious agents.
Washing liquid obtained from irrigation of the lung, including the BRONCHI and the PULMONARY ALVEOLI. It is generally used to assess biochemical, inflammatory, or infection status of the lung.
Pathological processes involving any part of the LUNG.
Diseases of LYMPH; LYMPH NODES; or LYMPHATIC VESSELS.
'Skin diseases' is a broad term for various conditions affecting the skin, including inflammatory disorders, infections, benign and malignant tumors, congenital abnormalities, and degenerative diseases, which can cause symptoms such as rashes, discoloration, eruptions, lesions, itching, or pain.
An erythematous eruption commonly associated with drug reactions or infection and characterized by inflammatory nodules that are usually tender, multiple, and bilateral. These nodules are located predominantly on the shins with less common occurrence on the thighs and forearms. They undergo characteristic color changes ending in temporary bruise-like areas. This condition usually subsides in 3-6 weeks without scarring or atrophy.
A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS).
Unstable isotopes of gallium that decay or disintegrate emitting radiation. Ga atoms with atomic weights 63-68, 70 and 72-76 are radioactive gallium isotopes.
Inflammation of part or all of the uvea, the middle (vascular) tunic of the eye, and commonly involving the other tunics (sclera and cornea, and the retina). (Dorland, 27th ed)
Endoscopic examination, therapy or surgery of the bronchi.
A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
A peptidyl-dipeptidase that catalyzes the release of a C-terminal dipeptide, -Xaa-*-Xbb-Xcc, when neither Xaa nor Xbb is Pro. It is a Cl(-)-dependent, zinc glycoprotein that is generally membrane-bound and active at neutral pH. It may also have endopeptidase activity on some substrates. (From Enzyme Nomenclature, 1992) EC 3.4.15.1.
Granulomatous disorders affecting one or more sites in the respiratory tract.
A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.
Adrenal cortex hormones are steroid hormones produced by the outer portion of the adrenal gland, consisting of glucocorticoids, mineralocorticoids, and androgens, which play crucial roles in various physiological processes such as metabolism regulation, stress response, electrolyte balance, and sexual development and function.
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
A manifestation of sarcoidosis marked by chronic inflammation of the parotid gland and the uvea.
Characteristic cells of granulomatous hypersensitivity. They appear as large, flattened cells with increased endoplasmic reticulum. They are believed to be activated macrophages that have differentiated as a result of prolonged antigenic stimulation. Further differentiation or fusion of epithelioid cells is thought to produce multinucleated giant cells (GIANT CELLS).
Abnormally high level of calcium in the blood.

Fitzgerald factor (high molecular weight kininogen) clotting activity in human plasma in health and disease in various animal plasmas. (1/1112)

Fitzgerald factor (high molecular weight kininogen) is an agent in normal human plasma that corrects the impaired in vitro surface-mediated plasma reactions of blood coagulation, fibrinolysis, and kinin generation observed in Fitzgerald trait plasma. To assess the possible pathophysiologic role of Fitzgerald factor, its titer was measured by a functional clot-promoting assay. Mean +/- SD in 42 normal adults was 0.99+/-0.25 units/ml, one unit being the activity in 1 ml of normal pooled plasma. No difference in titer was noted between normal men and women, during pregnancy, or after physical exercise. Fitzgerald factor activity was significantly reduced in the plasmas of eight patients with advanced hepatic cirrhosis (0.40+/-0.09 units/ml) and of ten patients with disseminated intravascular coagulation (0.60+/-0.30 units/ml), but was normal in plasmas of patients with other congenital clotting factor deficiencies, nephrotic syndrome, rheumatoid arthritis, systemic lupus erythematosus, or sarcoidosis, or under treatment with warfarin. The plasmas of 21 mammalian species tested appeared to contain Fitzgerald factor activity, but those of two avian, two repitilian, and one amphibian species did not correct the coagulant defect in Fitzgerald trait plasmas.  (+info)

Abnormal calcium metabolism in normocalcaemic sarcoidosis. (2/1112)

In studies of calcium metabolism in 13 unselected patients with untreated sarcoidosis all were normocalcaemic but five had hypercalcuria. All had normal renal function. Calcium absorption was indexed by a double isotope test. 45Ca hyperabsorption occurred in six patients. Ten kinetic studies were carried out with 47Ca and in six bone turnover was increased. 45Ca absorption correlated well with the calculated bone uptake rate of calcium, and with urine calcium excretion. These results suggest that in sarcoidosis abnormalities in calcium metabolism are fairly common although they rarely result in sustained hypercalcaemia.  (+info)

Sarcoidosis of the upper respiratory tract and its association with lupus pernio. (3/1112)

In a series of 34 patients with sarcoidosis affecting the upper respiratory tract and nose, 26 had lupus pernio (LP) and 17 had sarcoidosis of the upper respiratory tract (SURT). In nine patients these features coexisted. A patient presenting with SURT carried a 50% risk of developing LP although one feature could be present without the other. Both were disorders of women of the child-bearing years of life. SURT, like LP, was an indicator of chronic fibrotic sarcoidosis, developing insidiously and progressing indolently over the years. It was complicated by ulceration, septal perforation, and LP. Three patients had nasal septal perforations, in two instances following submucous resection. This operation is contraindicated in patients with active sarcoidosis, particularly when granulomas are found on nasal biopsy. The Kveim-Siltzbach skin test was positive in all patients with SURT, making it invaluable in the differential diagnosis of granuloma of the nasal cavity.  (+info)

Mycobacterium tuberculosis DNA in tissues affected by sarcoidosis. (4/1112)

BACKGROUND: Although some studies have reported the presence of Mycobacterium tuberculosis (MTb) DNA in tissues affected by sarcoidosis, the data are conflicting. The aim of this study was to collect prospectively tissue from patients with sarcoidosis in whom tuberculosis had been excluded, and to use polymerase chain reaction (PCR) to search for DNA sequences specific for MTb. METHODS: Fresh tissue samples (node or lung biopsy) taken from 23 patients with newly diagnosed sarcoidosis, 10 with other respiratory disease, and four patients with culture positive tuberculosis were analysed using PCR to amplify a 123 bp fragment of IS6110, the insertion element present in MTb, and nested PCR to further amplify an 85 bp sequence within the 123 bp product. DNA was also extracted from formalin fixed tissue from eight additional patients with sarcoidosis. RESULTS: MTb DNA was not detected in any of the tissue samples from patients with sarcoidosis or other respiratory disease but was found in all four patients with tuberculosis. CONCLUSIONS: This study has shown the absence of MTb DNA in lymph node and lung biopsy samples from patients with sarcoidosis. MTb is therefore unlikely to be a factor in the pathogenesis of this disease.  (+info)

Cutaneous sarcoidosis. (5/1112)

Sarcoidosis is a multi-organ granulomatous disorder of unknown cause. Skin sarcoidosis occurs in about 25% of patients with systemic disease and may also arise in isolation. A wide range of clinical presentations of cutaneous sarcoidosis is recognised. The diagnosis rests on the presence of non-caseating granulomas on skin biopsy and the exclusion of other granulomatous skin disease. The treatment and overall prognosis of cutaneous sarcoidosis is primarily dependent on the degree of systemic involvement. In patients with aggressive disease limited to the skin immunosuppressive therapy may be indicated.  (+info)

Enhanced expression of human metalloelastase (MMP-12) in cutaneous granulomas and macrophage migration. (6/1112)

Accumulation of inflammatory cells such as macrophages may lead to degeneration of connective tissue matrix in various skin diseases. Macrophage metalloelastase, is a matrix metalloproteinase (MMP-12) capable of degrading elastin as well as various basement membrane components. To investigate the role of human macrophage metalloelastase in skin, we assessed by in situ hybridization and immunohistochemistry 66 specimens representing skin diseases characterized either by changes in elastic fibers or by pronounced infiltrations of extravasating and migrating macrophages. CD68 immunostaining was performed to identify the human macrophage metalloelastase-positive cells and Weigert's Resorcin-Fuchsin staining to reveal the status of elastic fibers. We found abundant expression of human macrophage metalloelastase mRNA in macrophages in areas devoid of normal elastic fibers in granulomatous skin diseases sarcoidosis, necrobiosis lipoidica diabeticorum, and granuloma annulare. Positive cells for human macrophage metalloelastase protein could be detected in the same regions as well as positive immunostaining for urokinase plasminogen activator. Of the other matrix metalloproteinases capable of degrading elastin, 92 kDa gelatinase colocalized with human macrophage metalloelastase, while 72 kDa gelatinase was produced by surrounding fibroblast-like cells. Furthermore, human macrophage metalloelastase was expressed by macrophages in areas with disrupted basement membrane, as assessed by type IV collagen staining, in pityriasis lichenoides and dermatitis herpetiformis. Specimens of anetoderma, acrodermatitis chronica atrophicans and pseudoxanthoma elasticum showed no signal for human macrophage metalloelastase. Matrilysin was not detected in any of the samples investigated. Our study suggests that human macrophage metalloelastase may contribute to elastin degradation occurring in granulomatous skin diseases and may aid macrophage migration through the epidermal and vascular basement membranes in inflammatory disorders.  (+info)

Antibodies to the IL-12 receptor beta 2 chain mark human Th1 but not Th2 cells in vitro and in vivo. (7/1112)

Great attention has been placed on the possibility of distinguishing Th1 from Th2 cells on the basis of differential expression of surface receptors. We have recently shown that the differential expression of the IL-12R beta 2 chain in Th1 and Th2 cells, as measured at the mRNA level, accounts for an important regulatory mechanism in the differentiation of the two cell subsets. In this study, we identify IL-12R expression at the protein level. We have generated an anti-IL-12R beta 2-specific mAb and analyzed IL-12R beta 2 expression on polarized Th cell populations generated in vitro and on T cells derived from patients with Th1- or Th2-mediated inflammatory conditions. Although IL-12R beta 2 was absent in freshly isolated PBMC and in cord blood cells, we were able to detect IL-12R beta 2 expression selectively in differentiated Th1 and T cytotoxic 1, but not Th2 or T cytotoxic 2 cells. In the presence of IL-12, cell surface expression of the IL-12R beta 2 subunit was readily detected on T cells after 24 h, reached the maximum at day 5, and declined thereafter. Most importantly, the anti-IL-12R beta 2 mAb recognizes lung T cells from patients with sarcoidosis, a disease characterized by a typical cell-mediated, Th1-type inflammatory response. In contrast, IL-12R beta 2 was absent in lung T cells from patients with allergic asthma, a disease characterized by a Th2-type inflammatory response. The mAb reported in this study should represent a powerful tool to investigate the role of Th1 and Th2 cells in inflammatory conditions and to monitor therapies aimed at altering the balance of Th cell subsets.  (+info)

Central nervous system sarcoidosis--diagnosis and management. (8/1112)

A series of 68 patients with neurosarcoidosis is reported, with particular emphasis on clinical aspects, diagnosis and treatment. A classification system based on clinical diagnostic probability is proposed, consisting of probable and definite disease, the latter being dependent on finding sarcoid granulomas on nervous system histology, which was obtained in 12 patients (18%). The role of investigations, including magnetic resonance imaging (MRI), chest radiography, Kveim skin test, Gallium 67 isotope scanning and cerebrospinal fluid (CSF) studies, is considered. Sixty-two percent of patients presented with nervous system disease, most commonly affecting the optic nerve and chiasm. Other common presentations included cranial nerve palsies, spinal cord and brainstem manifestations. Investigations yielding most diagnostic information included the Kveim test (41/48, 85% positive), raised CSF protein and/or cells (50/62, 81%) and gallium 67 scan (14/31, 45%). Eleven out of 29 patients (38%) patients showed meningeal enhancement on MRI scanning and 43% of scans demonstrated multiple white-matter lesions. Mean follow-up for the group was 4.6 years. Forty-seven patients were seen for > 18 months, and over half of these patients progressed despite corticosteroid and other immunosuppressive therapies. The benefit of a large patient database prospectively studied, with extended follow-up is discussed in order to learn more about prognosis and advance therapy in neurosarcoidosis.  (+info)

Sarcoidosis is a multi-system disorder characterized by the formation of granulomas (small clumps of inflammatory cells) in various organs, most commonly the lungs and lymphatic system. These granulomas can impair the function of the affected organ(s), leading to a variety of symptoms. The exact cause of sarcoidosis is unknown, but it's thought to be an overactive immune response to an unknown antigen, possibly triggered by an infection, chemical exposure, or another environmental factor.

The diagnosis of sarcoidosis typically involves a combination of clinical evaluation, imaging studies (such as chest X-rays and CT scans), and laboratory tests (including blood tests and biopsies). While there is no cure for sarcoidosis, treatment may be necessary to manage symptoms and prevent complications. Corticosteroids are often used to suppress the immune system and reduce inflammation, while other medications may be prescribed to treat specific organ involvement or symptoms. In some cases, sarcoidosis may resolve on its own without any treatment.

Sarcoidosis, pulmonary is a specific form of sarcoidosis, which is a multisystem inflammatory disorder characterized by the formation of noncaseating granulomas (small clusters of immune cells) in one or more organs. In pulmonary sarcoidosis, these granulomas primarily affect the lungs, but can also involve the lymph nodes within the chest. The condition is often asymptomatic, but some individuals may experience symptoms such as cough, shortness of breath, chest pain, and fatigue. Pulmonary sarcoidosis can lead to complications like pulmonary fibrosis (scarring of lung tissue) and chronic interstitial lung disease, which can impact lung function and quality of life. The exact cause of sarcoidosis is unknown, but it is believed to involve an abnormal immune response triggered by exposure to certain antigens, such as environmental particles or infectious agents.

The Kveim test is a specific intradermal skin test that was used in the diagnosis of certain forms of vasculitis, such as sarcoidosis. The test involves the injection of a small amount of tissue from a patient with known sarcoidosis into the skin of the person being tested. If the individual has sarcoidosis, a positive reaction will occur within 2-3 months, characterized by the formation of a granuloma (a small nodular inflammatory lesion) at the injection site.

However, it's important to note that the Kveim test is no longer widely used due to several limitations, including the subjective nature of the results and the risk of transmitting infectious diseases from the donor tissue. Currently, sarcoidosis is diagnosed based on a combination of clinical symptoms, radiological findings, laboratory tests, and sometimes biopsy results.

A granuloma is a small, nodular inflammatory lesion that occurs in various tissues in response to chronic infection, foreign body reaction, or autoimmune conditions. Histologically, it is characterized by the presence of epithelioid macrophages, which are specialized immune cells with enlarged nuclei and abundant cytoplasm, often arranged in a palisading pattern around a central area containing necrotic debris, microorganisms, or foreign material.

Granulomas can be found in various medical conditions such as tuberculosis, sarcoidosis, fungal infections, and certain autoimmune disorders like Crohn's disease. The formation of granulomas is a complex process involving both innate and adaptive immune responses, which aim to contain and eliminate the offending agent while minimizing tissue damage.

Bronchoalveolar lavage (BAL) fluid is a type of clinical specimen obtained through a procedure called bronchoalveolar lavage. This procedure involves inserting a bronchoscope into the lungs and instilling a small amount of saline solution into a specific area of the lung, then gently aspirating the fluid back out. The fluid that is recovered is called bronchoalveolar lavage fluid.

BAL fluid contains cells and other substances that are present in the lower respiratory tract, including the alveoli (the tiny air sacs where gas exchange occurs). By analyzing BAL fluid, doctors can diagnose various lung conditions, such as pneumonia, interstitial lung disease, and lung cancer. They can also monitor the effectiveness of treatments for these conditions by comparing the composition of BAL fluid before and after treatment.

BAL fluid is typically analyzed for its cellular content, including the number and type of white blood cells present, as well as for the presence of bacteria, viruses, or other microorganisms. The fluid may also be tested for various proteins, enzymes, and other biomarkers that can provide additional information about lung health and disease.

Lung diseases refer to a broad category of disorders that affect the lungs and other structures within the respiratory system. These diseases can impair lung function, leading to symptoms such as coughing, shortness of breath, chest pain, and wheezing. They can be categorized into several types based on the underlying cause and nature of the disease process. Some common examples include:

1. Obstructive lung diseases: These are characterized by narrowing or blockage of the airways, making it difficult to breathe out. Examples include chronic obstructive pulmonary disease (COPD), asthma, bronchiectasis, and cystic fibrosis.
2. Restrictive lung diseases: These involve stiffening or scarring of the lungs, which reduces their ability to expand and take in air. Examples include idiopathic pulmonary fibrosis, sarcoidosis, and asbestosis.
3. Infectious lung diseases: These are caused by bacteria, viruses, fungi, or parasites that infect the lungs. Examples include pneumonia, tuberculosis, and influenza.
4. Vascular lung diseases: These affect the blood vessels in the lungs, impairing oxygen exchange. Examples include pulmonary embolism, pulmonary hypertension, and chronic thromboembolic pulmonary hypertension (CTEPH).
5. Neoplastic lung diseases: These involve abnormal growth of cells within the lungs, leading to cancer. Examples include small cell lung cancer, non-small cell lung cancer, and mesothelioma.
6. Other lung diseases: These include interstitial lung diseases, pleural effusions, and rare disorders such as pulmonary alveolar proteinosis and lymphangioleiomyomatosis (LAM).

It is important to note that this list is not exhaustive, and there are many other conditions that can affect the lungs. Proper diagnosis and treatment of lung diseases require consultation with a healthcare professional, such as a pulmonologist or respiratory therapist.

Lymphatic diseases refer to a group of conditions that affect the lymphatic system, which is an important part of the immune and circulatory systems. The lymphatic system consists of a network of vessels, organs, and tissues that help to transport lymph fluid throughout the body, fight infection, and remove waste products.

Lymphatic diseases can be caused by various factors, including genetics, infections, cancer, and autoimmune disorders. Some common types of lymphatic diseases include:

1. Lymphedema: A condition that causes swelling in the arms or legs due to a blockage or damage in the lymphatic vessels.
2. Lymphoma: A type of cancer that affects the lymphatic system, including Hodgkin's and non-Hodgkin's lymphoma.
3. Infections: Certain bacterial and viral infections can affect the lymphatic system, such as tuberculosis, cat-scratch disease, and HIV/AIDS.
4. Autoimmune disorders: Conditions such as rheumatoid arthritis, lupus, and scleroderma can cause inflammation and damage to the lymphatic system.
5. Congenital abnormalities: Some people are born with abnormalities in their lymphatic system, such as malformations or missing lymph nodes.

Symptoms of lymphatic diseases may vary depending on the specific condition and its severity. Treatment options may include medication, physical therapy, surgery, or radiation therapy. It is important to seek medical attention if you experience symptoms of a lymphatic disease, as early diagnosis and treatment can improve outcomes.

Skin diseases, also known as dermatological conditions, refer to any medical condition that affects the skin, which is the largest organ of the human body. These diseases can affect the skin's function, appearance, or overall health. They can be caused by various factors, including genetics, infections, allergies, environmental factors, and aging.

Skin diseases can present in many different forms, such as rashes, blisters, sores, discolorations, growths, or changes in texture. Some common examples of skin diseases include acne, eczema, psoriasis, dermatitis, fungal infections, viral infections, bacterial infections, and skin cancer.

The symptoms and severity of skin diseases can vary widely depending on the specific condition and individual factors. Some skin diseases are mild and can be treated with over-the-counter medications or topical creams, while others may require more intensive treatments such as prescription medications, light therapy, or even surgery.

It is important to seek medical attention if you experience any unusual or persistent changes in your skin, as some skin diseases can be serious or indicative of other underlying health conditions. A dermatologist is a medical doctor who specializes in the diagnosis and treatment of skin diseases.

Erythema nodosum is a type of inflammation that occurs in the fatty layer of the skin, causing painful, red or purple bumps (nodules) to form. It is a type of panniculitis, which refers to any condition that causes inflammation of the fatty layer of tissue beneath the skin.

Erythema nodosum is often associated with a variety of underlying conditions, such as infections (e.g., streptococcus, tuberculosis), medications (e.g., sulfa drugs, oral contraceptives), inflammatory bowel disease (e.g., Crohn's disease, ulcerative colitis), and pregnancy.

The bumps associated with erythema nodosum typically appear on the shins, ankles, knees, or other areas of the legs, although they can also occur on the arms, hands, or face. The bumps may be tender to the touch, warm, and swollen, and they may cause pain or discomfort when walking or standing for prolonged periods.

In most cases, erythema nodosum resolves on its own within a few weeks to several months, although symptoms can be managed with medications such as nonsteroidal anti-inflammatory drugs (NSAIDs) and corticosteroids. Treating the underlying condition is also important for resolving erythema nodosum and preventing recurrences.

Cardiomyopathies are a group of diseases that affect the heart muscle, leading to mechanical and/or electrical dysfunction. The American Heart Association (AHA) defines cardiomyopathies as "a heterogeneous group of diseases of the myocardium associated with mechanical and/or electrical dysfunction that usually (but not always) exhibit inappropriate ventricular hypertrophy or dilatation and frequently lead to heart failure."

There are several types of cardiomyopathies, including:

1. Dilated cardiomyopathy (DCM): This is the most common type of cardiomyopathy, characterized by an enlarged left ventricle and impaired systolic function, leading to heart failure.
2. Hypertrophic cardiomyopathy (HCM): In this type, there is abnormal thickening of the heart muscle, particularly in the septum between the two ventricles, which can obstruct blood flow and increase the risk of arrhythmias.
3. Restrictive cardiomyopathy (RCM): This is a rare form of cardiomyopathy characterized by stiffness of the heart muscle, impaired relaxation, and diastolic dysfunction, leading to reduced filling of the ventricles and heart failure.
4. Arrhythmogenic right ventricular cardiomyopathy (ARVC): In this type, there is replacement of the normal heart muscle with fatty or fibrous tissue, primarily affecting the right ventricle, which can lead to arrhythmias and sudden cardiac death.
5. Unclassified cardiomyopathies: These are conditions that do not fit into any of the above categories but still significantly affect the heart muscle and function.

Cardiomyopathies can be caused by genetic factors, acquired conditions (e.g., infections, toxins, or autoimmune disorders), or a combination of both. The diagnosis typically involves a comprehensive evaluation, including medical history, physical examination, electrocardiogram (ECG), echocardiography, cardiac magnetic resonance imaging (MRI), and sometimes genetic testing. Treatment depends on the type and severity of the condition but may include medications, lifestyle modifications, implantable devices, or even heart transplantation in severe cases.

Gallium radioisotopes refer to specific types of gallium atoms that have unstable nuclei and emit radiation as they decay towards a more stable state. These isotopes are commonly used in medical imaging, such as in gallium scans, to help diagnose conditions like inflammation, infection, or cancer.

Gallium-67 (^67^Ga) is one of the most commonly used radioisotopes for medical purposes. It has a half-life of about 3.26 days and decays by emitting gamma rays. When administered to a patient, gallium-67 binds to transferrin, a protein that carries iron in the blood, and is taken up by cells with increased metabolic activity, such as cancer cells or immune cells responding to infection or inflammation. The distribution of gallium-67 in the body can then be visualized using a gamma camera, providing valuable diagnostic information.

Uveitis is the inflammation of the uvea, the middle layer of the eye between the retina and the white of the eye (sclera). The uvea consists of the iris, ciliary body, and choroid. Uveitis can cause redness, pain, and vision loss. It can be caused by various systemic diseases, infections, or trauma. Depending on the part of the uvea that's affected, uveitis can be classified as anterior (iritis), intermediate (cyclitis), posterior (choroiditis), or pan-uveitis (affecting all layers). Treatment typically includes corticosteroids and other immunosuppressive drugs to control inflammation.

Bronchoscopy is a medical procedure that involves the examination of the inside of the airways and lungs with a flexible or rigid tube called a bronchoscope. This procedure allows healthcare professionals to directly visualize the airways, take tissue samples for biopsy, and remove foreign objects or secretions. Bronchoscopy can be used to diagnose and manage various respiratory conditions such as lung infections, inflammation, cancer, and bleeding. It is usually performed under local or general anesthesia to minimize discomfort and risks associated with the procedure.

Prednisolone is a synthetic glucocorticoid drug, which is a class of steroid hormones. It is commonly used in the treatment of various inflammatory and autoimmune conditions due to its potent anti-inflammatory and immunosuppressive effects. Prednisolone works by binding to specific receptors in cells, leading to changes in gene expression that reduce the production of substances involved in inflammation, such as cytokines and prostaglandins.

Prednisolone is available in various forms, including tablets, syrups, and injectable solutions. It can be used to treat a wide range of medical conditions, including asthma, rheumatoid arthritis, inflammatory bowel disease, allergies, skin conditions, and certain types of cancer.

Like other steroid medications, prednisolone can have significant side effects if used in high doses or for long periods of time. These may include weight gain, mood changes, increased risk of infections, osteoporosis, diabetes, and adrenal suppression. As a result, the use of prednisolone should be closely monitored by a healthcare professional to ensure that its benefits outweigh its risks.

Peptidyl-dipeptidase A is more commonly known as angiotensin-converting enzyme (ACE). It is a key enzyme in the renin-angiotensin-aldosterone system (RAAS), which regulates blood pressure and fluid balance.

ACE is a membrane-bound enzyme found primarily in the lungs, but also in other tissues such as the heart, kidneys, and blood vessels. It plays a crucial role in converting the inactive decapeptide angiotensin I into the potent vasoconstrictor octapeptide angiotensin II, which constricts blood vessels and increases blood pressure.

ACE also degrades the peptide bradykinin, which is involved in the regulation of blood flow and vascular permeability. By breaking down bradykinin, ACE helps to counteract its vasodilatory effects, thereby maintaining blood pressure homeostasis.

Inhibitors of ACE are widely used as medications for the treatment of hypertension, heart failure, and diabetic kidney disease, among other conditions. These drugs work by blocking the action of ACE, leading to decreased levels of angiotensin II and increased levels of bradykinin, which results in vasodilation, reduced blood pressure, and improved cardiovascular function.

A granuloma in the respiratory tract refers to a small nodular lesion that forms in the lung tissue due to an ongoing immune response. It is typically composed of macrophages, lymphocytes, and other inflammatory cells that cluster together around a foreign substance or organism that the body cannot eliminate.

Granulomas can form in response to various stimuli, including infectious agents such as mycobacteria (tuberculosis, nontuberculous mycobacteria), fungi, and parasites, as well as non-infectious causes like inhaled particles (e.g., silica, beryllium) or autoimmune diseases (e.g., sarcoidosis).

These lesions can cause damage to the lung tissue over time, leading to symptoms such as cough, shortness of breath, chest pain, and fatigue. Diagnosis often involves imaging studies like chest X-rays or CT scans, followed by biopsy and microscopic examination to confirm the presence of granulomas and identify the underlying cause. Treatment depends on the underlying cause but may include antibiotics, corticosteroids, or other immunosuppressive medications.

Pulmonary fibrosis is a specific type of lung disease that results from the thickening and scarring of the lung tissues, particularly those in the alveoli (air sacs) and interstitium (the space around the air sacs). This scarring makes it harder for the lungs to properly expand and transfer oxygen into the bloodstream, leading to symptoms such as shortness of breath, coughing, fatigue, and eventually respiratory failure. The exact cause of pulmonary fibrosis can vary, with some cases being idiopathic (without a known cause) or related to environmental factors, medications, medical conditions, or genetic predisposition.

The adrenal cortex hormones are a group of steroid hormones produced and released by the outer portion (cortex) of the adrenal glands, which are located on top of each kidney. These hormones play crucial roles in regulating various physiological processes, including:

1. Glucose metabolism: Cortisol helps control blood sugar levels by increasing glucose production in the liver and reducing its uptake in peripheral tissues.
2. Protein and fat metabolism: Cortisol promotes protein breakdown and fatty acid mobilization, providing essential building blocks for energy production during stressful situations.
3. Immune response regulation: Cortisol suppresses immune function to prevent overactivation and potential damage to the body during stress.
4. Cardiovascular function: Aldosterone regulates electrolyte balance and blood pressure by promoting sodium reabsorption and potassium excretion in the kidneys.
5. Sex hormone production: The adrenal cortex produces small amounts of sex hormones, such as androgens and estrogens, which contribute to sexual development and function.
6. Growth and development: Cortisol plays a role in normal growth and development by influencing the activity of growth-promoting hormones like insulin-like growth factor 1 (IGF-1).

The main adrenal cortex hormones include:

1. Glucocorticoids: Cortisol is the primary glucocorticoid, responsible for regulating metabolism and stress response.
2. Mineralocorticoids: Aldosterone is the primary mineralocorticoid, involved in electrolyte balance and blood pressure regulation.
3. Androgens: Dehydroepiandrosterone (DHEA) and its sulfate derivative (DHEAS) are the most abundant adrenal androgens, contributing to sexual development and function.
4. Estrogens: Small amounts of estrogens are produced by the adrenal cortex, mainly in women.

Disorders related to impaired adrenal cortex hormone production or regulation can lead to various clinical manifestations, such as Addison's disease (adrenal insufficiency), Cushing's syndrome (hypercortisolism), and congenital adrenal hyperplasia (CAH).

A biopsy is a medical procedure in which a small sample of tissue is taken from the body to be examined under a microscope for the presence of disease. This can help doctors diagnose and monitor various medical conditions, such as cancer, infections, or autoimmune disorders. The type of biopsy performed will depend on the location and nature of the suspected condition. Some common types of biopsies include:

1. Incisional biopsy: In this procedure, a surgeon removes a piece of tissue from an abnormal area using a scalpel or other surgical instrument. This type of biopsy is often used when the lesion is too large to be removed entirely during the initial biopsy.

2. Excisional biopsy: An excisional biopsy involves removing the entire abnormal area, along with a margin of healthy tissue surrounding it. This technique is typically employed for smaller lesions or when cancer is suspected.

3. Needle biopsy: A needle biopsy uses a thin, hollow needle to extract cells or fluid from the body. There are two main types of needle biopsies: fine-needle aspiration (FNA) and core needle biopsy. FNA extracts loose cells, while a core needle biopsy removes a small piece of tissue.

4. Punch biopsy: In a punch biopsy, a round, sharp tool is used to remove a small cylindrical sample of skin tissue. This type of biopsy is often used for evaluating rashes or other skin abnormalities.

5. Shave biopsy: During a shave biopsy, a thin slice of tissue is removed from the surface of the skin using a sharp razor-like instrument. This technique is typically used for superficial lesions or growths on the skin.

After the biopsy sample has been collected, it is sent to a laboratory where a pathologist will examine the tissue under a microscope and provide a diagnosis based on their findings. The results of the biopsy can help guide further treatment decisions and determine the best course of action for managing the patient's condition.

A lung is a pair of spongy, elastic organs in the chest that work together to enable breathing. They are responsible for taking in oxygen and expelling carbon dioxide through the process of respiration. The left lung has two lobes, while the right lung has three lobes. The lungs are protected by the ribcage and are covered by a double-layered membrane called the pleura. The trachea divides into two bronchi, which further divide into smaller bronchioles, leading to millions of tiny air sacs called alveoli, where the exchange of gases occurs.

Uveoparotid fever, also known as Heerfordt's syndrome, is not precisely defined as a fever. Instead, it is a rare manifestation of sarcoidosis, a multisystem granulomatous disorder of unknown cause. The condition is named after the Danish ophthalmologist, Christian Frederik Heerfordt, who first described it in 1909.

Uveoparotid fever is characterized by the following symptoms:

1. Uveitis: Inflammation of the uveal tract, which includes the iris, ciliary body, and choroid, leading to eye pain, redness, photophobia (sensitivity to light), blurred vision, and floaters.
2. Parotid gland enlargement: Swelling of one or both parotid glands, located in front of and below the ears.
3. Facial palsy: Weakness or loss of movement on one side of the face, similar to Bell's palsy.
4. Fever: Elevated body temperature may be present but is not always a consistent finding.

Other possible symptoms associated with sarcoidosis include cough, shortness of breath, skin rashes, fatigue, and joint pain. The diagnosis typically involves a combination of clinical presentation, imaging studies, and tissue biopsy to confirm the presence of noncaseating granulomas, which are characteristic of sarcoidosis. Treatment usually includes corticosteroids and immunosuppressive therapy to manage inflammation and prevent complications.

Epithelioid cells are a type of cell that can be found in certain types of tissue in the body, including connective tissue and some organs. These cells have a characteristic appearance under a microscope, with an enlarged, oval or round shape and a pale, abundant cytoplasm. They may also have a nucleus that is centrally located and has a uniform, rounded shape.

Epithelioid cells are often seen in the context of inflammation or disease, particularly in relation to granulomatous disorders such as sarcoidosis and tuberculosis. In these conditions, epithelioid cells can form clusters known as granulomas, which are a hallmark of the diseases. The exact function of epithelioid cells is not fully understood, but they are thought to play a role in the immune response and may help to contain and eliminate foreign substances or pathogens from the body.

Hypercalcemia is a medical condition characterized by an excess of calcium ( Ca2+ ) in the blood. While the normal range for serum calcium levels is typically between 8.5 to 10.2 mg/dL (milligrams per deciliter) or 2.14 to 2.55 mmol/L (millimoles per liter), hypercalcemia is generally defined as a serum calcium level greater than 10.5 mg/dL or 2.6 mmol/L.

Hypercalcemia can result from various underlying medical disorders, including primary hyperparathyroidism, malignancy (cancer), certain medications, granulomatous diseases, and excessive vitamin D intake or production. Symptoms of hypercalcemia may include fatigue, weakness, confusion, memory loss, depression, constipation, nausea, vomiting, increased thirst, frequent urination, bone pain, and kidney stones. Severe or prolonged hypercalcemia can lead to serious complications such as kidney failure, cardiac arrhythmias, and calcification of soft tissues. Treatment depends on the underlying cause and severity of the condition.

... may be divided into the following types: Annular sarcoidosis Erythrodermic sarcoidosis Ichthyosiform sarcoidosis ... in sarcoidosis Asteroid body in sarcoidosis Hamazaki-Wesenberg bodies in sarcoidosis in lymph node Diagnosis of sarcoidosis is ... Papular sarcoid Scar sarcoid Subcutaneous sarcoidosis Systemic sarcoidosis Ulcerative sarcoidosis Treatments for sarcoidosis ... especially CNS sarcoidosis; minimally effective in sarcoidosis myopathy), and pulmonary sarcoidosis. As the granulomas are ...
Sarcoidosis is a systemic disease of unknown cause that results in the formation of non-caseating granulomas in multiple organs ... Testicular sarcoidosis can present as a diffuse painless scrotal mass or can mimic acute epididymo-orchitis. Usually it appears ... The peak incidence of sarcoidosis and testicular neoplasia coincide at 20-40 years and this is why most patients end up having ... Paknejad O, Gilani MA, Khoshchehreh M (2011). "Testicular masses in a man with a plausible sarcoidosis". Indian J. Urol. 27 (2 ...
Ulcerative sarcoidosis is a cutaneous condition affecting roughly 5% of people with sarcoidosis.: 710 Annular sarcoidosis is a ... 711 Erythrodermic sarcoidosis is a cutaneous condition and very rare form of sarcoidosis.: 710 Hypopigmented sarcoidosis is a ... by caused by sarcoidosis.: 710 Subcutaneous sarcoidosis (also known as "Darier-Roussy disease" and "Darier-Roussy sarcoid") is ... 709 Morpheaform sarcoidosis is a very rare cutaneous condition characterized by specific cutaneous skin lesions of sarcoidosis ...
It was co-founded by D. Geraint James, who had set up the first international conference on sarcoidosis almost 30 years earlier ... "Statement on Sarcoidosis". American Journal of Respiratory and Critical Care Medicine. 160 (2): 736-755. 1 August 1999. doi: ... The World Association of Sarcoidosis and other Granulomatous Disorders, also known as WASOG is an organisation of physicians ... Drent, M.; Costabel, U. (2005). Sarcoidosis: European Respiratory Monograph. European Respiratory Society. p. 336. ISBN ...
... it was classified as a distinct manifestation of sarcoidosis. Darier-Roussy disease Sarcoidosis List of cutaneous conditions ... Heerfordt syndrome is present in 4.1 to 5.6% of those with sarcoidosis. The condition was first described in 1909 by Danish ... In the United States, sarcoidosis has a prevalence of approximately 10 cases per 100,000 whites and 36 cases per 100,000 blacks ... In patients that have already been diagnosed with sarcoidosis, Heerfordt syndrome can be inferred from the major symptoms of ...
Subcutaneous sarcoidosis (Darier-Roussy disease, Darier-Roussy sarcoid) Systemic sarcoidosis Ulcerative sarcoidosis Xanthoma ... Letterer-Siwe disease Localized granuloma annulare Löfgren syndrome Lupus pernio Morpheaform sarcoidosis Mucosal sarcoidosis ... Dempsey OJ, Paterson EW, Kerr KM, Denison AR (2009). "Sarcoidosis". BMJ. 339: b3206. doi:10.1136/bmj.b3206. PMID 19717499. ... disease Heerfordt's syndrome Hereditary progressive mucinous histiocytosis Hypopigmented sarcoidosis Ichthyosiform sarcoidosis ...
"Sarcoidosis". The Lecturio Medical Concept Library. Retrieved 22 August 2021. "Whipple's Disease". The Lecturio Medical Concept ... Henoch-Schönlein purpura Hyperimmunoglobulinemia D with recurrent fever Sarcoidosis Whipple's disease TNF receptor associated ...
Sharma OP (March 1993). "Arthur Conan Doyle and Jonathan Hutchinson: the sarcoidosis connection". Sarcoidosis. 10 (1): 69-70. ... Geraint DJ (June 2002). "Pioneers of sarcoidosis: Jonathan Hutchinson (1828-1913)". Sarcoidosis, Vasculitis and Diffuse Lung ... Sharma OP (March 1986). "Vanity Fair, Spy and Jonathan Hutchinson". Sarcoidosis. 3 (1): 75-6. PMID 3554427. Key JD, Mann RJ ( ... James, D. G. (1969). "Centenary commemoration of sarcoidosis and of Jonathan Hutchinson". British Medical Journal. 2 (5649): ...
Subsequently, with the personal financial support of Gianfranco Rizzato, the journal Sarcoidosis, later renamed Sarcoidosis ... Sarcoidosis and Other Granulomatous Disorders, co-authored with W. Jones, and published by W. B. Saunders, the clinical and ... James's lifetime work on sarcoidosis led him to be known as the "King of Sarcoid". In 1964 James was elected President of the ... By 1958, James had written seven papers on sarcoidosis, two being on its effects on eyes, and had published his first book The ...
"Sarcoidosis , Doctor , Patient". Patient. Retrieved 2016-03-11. Dennis, Mark; Bowen, William Talbot; Cho, Lucy (2012-01-01). ... Sarcoidosis The mechanism of hepatomegaly consists of vascular swelling, inflammation (infectious in origin), and deposition of ...
Sarcoidosis is a disease of unknown cause characterized by non-necrotizing ("non-caseating") granulomas in multiple organs and ... The granulomas of sarcoidosis are similar to those of tuberculosis and other infectious granulomatous diseases. In most cases ... Necrosis in granulomas Granuloma without necrosis in a lymph node of a person with sarcoidosis Granuloma with central necrosis ... Iannuzzi M, Rybicki BA, Teirstein AS (2007). "Sarcoidosis". New England Journal of Medicine. 357 (21): 2153-2165. doi:10.1056/ ...
James WE (2019-01-01). "Chapter 23 - Nonpharmacological Therapy for Pulmonary Sarcoidosis". In Baughman RP, Valeyre D (eds.). ... Sarcoidosis. Philadelphia: Elsevier. pp. 277-284. doi:10.1016/b978-0-323-54429-0.00023-9. ISBN 978-0-323-54429-0. S2CID ...
"More Information". Sarcoidosis Program. Retrieved 2019-08-09. Sanofi halts tests of arthritis drug for use as a COVID-19 ... In July 2019, a multi-center trial was launched to study 'Sarilumab in Patients With Glucocorticoid-Dependent Sarcoidosis.' In ...
He had sarcoidosis. Armstrong was born in Holden, Alberta, in 1941. He bought his first car, a 1936 Ford Coupe, for five ...
... can also occur as a result of vocal cord dysfunction (VCD). Sarcoidosis is an inflammatory disease of ... Bokhari, SRA; Zulfiqar, H; Mansur, A (January 2021). Sarcoidosis in StatPearls. PMID 28613460. Harrison's Principles of ...
... has been used off-label in treating refractory sarcoidosis, where other treatments have not been effective. ... Wijsenbeek MS, Culver DA (December 2015). "Treatment of Sarcoidosis". Clinics in Chest Medicine. 36 (4): 751-767. doi:10.1016/j ...
List of cutaneous conditions Sarcoidosis Ohta H, Tazawa R, Nakamura A, et al. (2006). "Acute-onset sarcoidosis with erythema ... Löfgren syndrome is a type of acute sarcoidosis, an inflammatory disorder characterized by swollen lymph nodes in the chest, ... Löfgren S (1953). "Primary pulmonary sarcoidosis. I. Early signs and symptoms". Acta Med Scand. 145 (6): 424-431. doi:10.1111/j ...
HGSNAT Sarcoidosis, early-onset; 609464; NOD2 SC phocomelia syndrome; 269000; ESCO2 Scapuloperoneal myopathy, X-linked dominant ...
Scott RB (15 October 1938). "The Sarcoidosis of Boeck". Br Med J. 2 (4058): 777-781, 800-1. doi:10.1136/bmj.2.4058.777. PMC ...
van Maarsseveen, Ton C.; de Groot, Jan; Stam, Jaap; van Diest, Paul J. (1993-05-01). "Peripolesis in Alveolar Sarcoidosis". ... In patients with active sarcoidosis, which is characterized by lymphocyte-macrophage cooperation, lymphocyte peripolesis ...
Hedfors E, Holm G, Pettersson D (June 1974). "Lymphocyte subpopulations in sarcoidosis". Clinical and Experimental Immunology. ... sarcoidosis, multiple sclerosis, and iatrogenic (caused by other medical treatments) conditions. Lymphocytopenia is a frequent ...
Ishihara M, Ohno S (Nov 1997). "Genetic influences on sarcoidosis". Eye. 11. 11 (2): 155-61. doi:10.1038/eye.1997.44. PMID ...
Early onset sarcoidosis is Blau syndrome without a family history, Blau syndrome has been diagnosed in patients who have not ... "Blau's Disease / Juvenile Sarcoidosis". www.printo.it. Kaufman, Katherine; Becker, Mara (9 February 2021). "Distinguishing Blau ... Symptoms usually begin before the age of four, and the disease manifests as early onset cutaneous sarcoidosis, granulomatous ... from Blau syndrome and early-onset sarcoidosis to NOD2-mediated disease and Crohn's disease. RMD Open 2015; 1: e000097. PMID ...
KaradaÄŸ, AS; Parish, LC (2019-05-01). "Sarcoidosis: a great imitator". Clinics in Dermatology. 37 (3): 240-254. doi:10.1016/j. ... Tchernev, G (2006). "Cutaneous sarcoidosis: The 'great imitator': Etiopathogenesis, morphology, differential diagnosis, and ... Sarcoidosis Endometriosis, often misdiagnosed Multiple sclerosis Celiac disease Closely related to gut function is liver ...
Sarcoidosis: Nephrocalcinosis is one of the most common symptoms. Vitamin D: This can cause nephrocalcinosis because of vitamin ... Muther, R. S.; McCarron, D. A.; Bennett, W. M. (April 1981). "Renal manifestations of sarcoidosis". Archives of Internal ...
Bogart, A.S.; Daniel, D.D.; Poster, K.G. (1954). "Cortisone Treatment of Sarcoidosis". Diseases of the Chest. 26 (2): 224-228. ... and stop the development of sarcoidosis. Oral use of cortisone has a number of potential systemic adverse effects, including ...
... sarcoidosis in the lungs; and to treat edema in certain nephrotic syndromes. In the UK tetracosactide is used for short-term ...
Chen ES (September 2016). "Innate immunity in sarcoidosis pathobiology". Current Opinion in Pulmonary Medicine. 22 (5): 469-475 ... of function with development of Crohn's disease and early-onset sarcoidosis. Mutations in NOD2 in cooperation with ...
Heck AW, Phillips LH (August 1989). "Sarcoidosis and the nervous system". Neurologic Clinics. 7 (3): 641-54. doi:10.1016/S0733- ... sarcoidosis. Multiple sclerosis may also be causal. Vitamin deficiency states: Vitamin B12 (Methylcobalamin), vitamin A, ... HIV Sarcoidosis Cryoglobulinemia Reactions to exposure to chemical agents, including trichloroethylene and dapsone[medical ...
"T-lymphocyte activity in HLA-DR17 positive patients with active and clinically recovered sarcoidosis". Sarcoidosis Vasc Diffuse ... 2007). "HLA class I and class II frequencies in patients with sarcoidosis from Croatia: role of HLA-B8, −DRB1*0301, and −DQB1* ... DR17 is associated with non-chronic sarcoidosis, infantile spasm/epilepsy, rabies vaccine-induced autoimmune encephalomyelitis ... "HLA-DR predicts the prognosis in Scandinavian patients with pulmonary sarcoidosis". Am J Respir Crit Care Med. 156 (5): 1601-5 ...
Sarcoidosis may be divided into the following types: Annular sarcoidosis Erythrodermic sarcoidosis Ichthyosiform sarcoidosis ... in sarcoidosis Asteroid body in sarcoidosis Hamazaki-Wesenberg bodies in sarcoidosis in lymph node Diagnosis of sarcoidosis is ... Papular sarcoid Scar sarcoid Subcutaneous sarcoidosis Systemic sarcoidosis Ulcerative sarcoidosis Treatments for sarcoidosis ... especially CNS sarcoidosis; minimally effective in sarcoidosis myopathy), and pulmonary sarcoidosis. As the granulomas are ...
... Arch Neurol. 1985 Sep;42(9):909-17. doi: 10.1001/archneur.1985.04060080095022. ... The presenting manifestation of sarcoidosis was neurological in 16 (48%) of them. Cranial neuropathy was the most frequent ...
Perhaps more likely is that, as is the case in sarcoidosis occurring in scars, tattoos act to localize the granulomatous ...
Sarcoidosis was originally called Hutchinsons disease or Boecks disease. Sarcoidosis was once considered a rare disease. We ... Much about the cause(s) of sarcoidosis remains unknown. But, if you have sarcoidosis you can be reassured that patients with ... Sarcoidosis is a disease due to inflammation. It can appear in almost any organ of the body most often affecting the lungs, ... Sarcoidosis is not cancer. It is not contagious, and your friends and family will not catch it from you. ...
The description of sarcoidosis goes back to 1899, when Caesar Boeck described the skin nodules characterized by epithelioid ... Sarcoidosis, a systemic, granulomatous disease, can occur in adult and pediatric patients, but it is nonetheless relatively ... Management of pediatric sarcoidosis. The goal of therapy in sarcoidosis is to prevent or minimize inflammation and granuloma ... Signs and symptoms of pediatric sarcoidosis. The presentation in sarcoidosis can vary widely, depending on the extent and ...
Basic facts about sarcoidosis, including its signs and symptoms, how it affects breathing, and ways to manage the disease after ... Basic facts about sarcoidosis, including its signs and symptoms, how it affects breathing, and ways to manage the disease after ...
Johns Hopkins Sarcoidosis Registry, which is working to understand the extent and severity of sarcoidosis in our patients and ... Johns Hopkins remains in the forefront of sarcoidosis research with a mission to improve our understanding of sarcoidosis and ... If you would like to be part of our mission to improve the lives of those affected by sarcoidosis, please reach out to us at [ ... Understanding medication adherence and its effect on clinical outcomes and quality of life in sarcoidosis ...
ORGANS MOST OFTEN INVOLVED BY SARCOIDOSIS * Lung * Skin * Eye OTHER ORGANS INVOLVED BY SARCOIDOSIS * Liver * Musculoskeletal ... In symptomatic patients, sarcoidosis can involve one or more body systems and present with a wide variety of signs and symptoms ... The organs affected by sarcoidosis are listed roughly in their order of frequency and then considered individually. ... As many as one-half of patients with sarcoidosis are asymptomatic. These patients are usually discovered because of an abnormal ...
Subscribe and receive a weekly email with important information about scleroderma and the National Scleroderma Foundation. ...
Sarcoidosis is manifested by the presence of noncaseating granulomas (NCGs) in affected organ tissues. ... Sarcoidosis is a multisystem inflammatory disease of unknown etiology that predominantly affects the lungs and intrathoracic ... encoded search term (Sarcoidosis) and Sarcoidosis What to Read Next on Medscape ... Sarcoidosis Workup. Updated: Feb 09, 2022 * Author: Nader Kamangar, MD, FACP, FCCP, FCCM; Chief Editor: Zab Mosenifar, MD, FACP ...
Neurological symptoms can be significant manifestations of sarcoidosis. Facial nerve paralysis is a common, but usually self- ... Diagnosis and management of neurological sarcoidosis Arch Intern Med. 1997 Sep 8;157(16):1864-8. ... Methods: We analyzed all patients with sarcoidosis seen in our clinic during a 10-year period. Evaluation for neurological ... Our interest in immunosuppressive agents for chronic sarcoidosis has given us experience with various agents for the treatment ...
Sarcoidosis, an inflammatory disease of unknown cause that can affect almost any organ, has been noted in unexpectedly large ... Clinical Course of Sarcoidosis in World Trade Center Exposed Firefighters. Chest. 153(1):114-123. ... We will also assess genetic differences with similarly WTC-exposed firefighters who did not develop sarcoidosis. The results ... their clinical patterns and genetic markers and compare them with those of previously reported non-WTC-exposed sarcoidosis ...
What is sarcoidosis?. What are the symptoms of sarcoidosis?. How is sarcoidosis diagnosed?. How is sarcoidosis treated?. ... Sarcoidosis very rarely affects children.. What are the symptoms of sarcoidosis?. Sarcoidosis can affect almost any organ so ... How is sarcoidosis treated?. Acute sarcoidosis goes away without treatment in up to 90 per cent of cases. Painkillers such as ... What is sarcoidosis?. Sarcoidosis is a disease that leads to tiny lumps (called granulomas) developing in and on your body. ...
PET/MRI superior for diagnosing cardiac sarcoidosis. PET/MRI scans are more accurate for diagnosing cardiac sarcoidosis than ... Cardiac sarcoidosis is an inflammatory disease that can adversely affect heart function and lead to morbidity and mortality. ... On the other hand, many cardiac sarcoidosis patients have implantable cardiac devices (ICDs). It is unlikely that will change, ... "The true generalizability of hybrid PET/MRI for cardiac sarcoidosis, therefore, remains in question," they added. "Although the ...
... () Halil Yanardag, Cuneyt Tetikkurt, Aslı Sezgin, Ertuğrul ... Tani, K., Kasho, M., Sano, N., Nalamura, Y., Ogushi, F. and Sone, S. (1998) A case of sarcoidosis associated with chronic ... Yanardag, H. , Tetikkurt, C. , Sezgin, A. , Oruc, E. and Bilir, M. (2014) A case of sarcoidosis associated with chronic ... 2000) Peripheral blood eosinophilia in association with sarcoidosis. Mayo Clinic Proceedings, 75, 586-590.. http://dx.doi.org/ ...
Sarcoidosis is a rare disease where small lumps form in the body. The lumps are called granulomas. They can lead to ... Sarcoidosis may not cause symptoms at first. Symptoms that happen depend on the organs involved. Symptoms may be:. *Lasting ... There is no cure for sarcoidosis. The goal is to manage symptoms. If the condition is mild, treatment may not be needed. If ... The exact cause of sarcoidosis is not known. It is likely due to genes and the environment. ...
i,Methods,/i,. A sample of 1197 German sarcoidosis patients was examined with the Epworth Sleepiness Scale (ESS), the Fatigue ... i,Conclusions,/i,. The issue of excessive daytime sleepiness should be considered in the management of sarcoidosis. ... i,Background,/i,. The aim of this study was to analyze daytime sleepiness in a sample of patients diagnosed with sarcoidosis. , ... R. Marcellis, M. van der Veeke, I. Mesters et al., "Does physical training reduce fatigue in sarcoidosis?" Sarcoidosis ...
Sarcoidosis is a multisystem granulomatous inflammatory disease that usually clears on its own. But if it affects certain ... Tags:#sarcoidosis symptoms #sarcoidosis disease #sarcoidosis treatment #cardiac sarcoidosis #sarcoidosis diagnosis #sarcoidosis ... Cardiac Sarcoidosis Sarcoidosis affects the heart in 5 to 25% of sarcoidosis cases. Sarcoidosis can affect any part of the ... Sarcoidosis is also known as sarcoid or Besnier-Boeck disease.. Sarcoidosis. Sarcoidosis can appear all of a sudden and vanish ...
Patient had a normal coronary angiogram, and biopsy results consistent with sarcoidosis.. Figure 4: Whole body FDG PET image ... Figure 2: Perfusion and metabolic patterns on FDG PET CT corresponding with cardiac sarcoidosis.. Figure 3: Patient with a ... These findings are considered secondary to chronic fibrosis in this patient with longstanding sarcoidosis.. Figure 6: Use of ... Sarcoidosis is an inflammatory disorder of non-caseating granulomas, involving any organ. Cardiac involvement is common, and ...
Sarcoidosis. Sacroidosis is a disease that occurs as a result of inflammation to certain forms of body tissues. All organs in ...
Sarcoidosis is a disease that causes the formation of tiny clumps of cells on one or more organs in the body. ... Sarcoidosis is an inflammatory disease that causes the formation of tiny clusters of cells, called granulomas, in one or more ... Sarcoidosis can either be acute or chronic, with the condition considered chronic if it remains active longer than two years. ... Because treatment for sarcoidosis isnt curative, ongoing care is required. Your medical provider will create a care plan that ...
A group for people in our area dealing with this incurable disease, to come together to share their stories, health tips and support. For more information, call Sabrina Sonnier at 337-287-6709.
After youre diagnosed with sarcoidosis, its important to find a specialist who has experience with sarcoidosis. ... If youve been diagnosed with sarcoidosis, you might feel anxious and unsure about your health or have symptoms that interfere ... Managing Sarcoidosis. If you have sarcoidosis, you may need to work with doctors and specialists in different areas of ... People with sarcoidosis can have very different symptoms from each other. Many people with sarcoidosis have breathing problems ...
1994) A search for mycobacterial DNA in sarcoidosis using the polymerase chain reaction. Am J Clin Pathol 101:733-737, . ... The debate about sarcoidosis MTb and mycobacteria is not over.20 Cell wall deficient forms of mycobacteria have been postulated ... Graham et al identified mycobacteria found in skin lesions of patients with sarcoidosis as M avium 9 but the report is in ... Bocart et al studied tissue or cells from 16 patients with new or old sarcoidosis using similar technology to our study.12 In ...
Sarcoidosis. Sarcoidosis is a rare disease that causes inflammation and scar tissue throughout the body, especially the lungs, ... The cause of sarcoidosis is not known.. Symptoms may include fever, body aches, swollen lymph nodes, shortness of breath, ... But sometimes sarcoidosis does not cause any symptoms. It may lead to lung (respiratory) failure and heart problems in some ... Not everyone who has sarcoidosis needs treatment. Sometimes the disease goes away on its own. It may be treated with ...
Both Sarcoidosis and Lymphoma cause the lymph glands as well as nodes to swell. Sarcoidosis involves a high risk of cancer in ... Both Sarcoidosis and Lymphoma cause the lymph glands as well as nodes to swell. Sarcoidosis involves a high risk of cancer in ... What is Sarcoidosis?. Sarcoidosis is a disease or disorder that is specified by the development of small collections of ... Difference between Sarcoidosis and Lymphoma. The following table highlights the major differences between Sarcoidosis and ...
Sarcoidosis, Large Nodular Type. definition. Skin manifestation of sarcoidosis characterized by large bluish-red nodules and ... It is often associated with other forms of sarcoidosis including upper respiratory tract sarcoidosis, bone cysts, lacrimal ...
Mount Sinai Health System offers expert sarcoidosis services at locations in Manhattan and Brooklyn. ... Sarcoidosis. Mount Sinai Health System offers expert sarcoidosis services at these metropolitan New York locations. ...
  • In 2015, pulmonary sarcoidosis and interstitial lung disease affected 1.9 million people globally and they resulted in 122,000 deaths. (wikipedia.org)
  • Sarcoidosis, the etiology of which is unknown, most commonly affects young adults, who frequently present with hilar lymphadenopathy , pulmonary infiltration, and ocular and cutaneous lesions. (medscape.com)
  • Air trapping is a common feature in sarcoidosis that can be supported with imaging studies and correlates with evidence of small airways disease on pulmonary function testing. (medscape.com)
  • Of the four cases with elevated sACE, one had respiratory function test abnormalities and an abnormal chest x ray compatible with pulmonary sarcoidosis. (bmj.com)
  • If you're experiencing signs or symptoms of pulmonary sarcoidosis, schedule an appointment or call 800-TEMPLE-MED (800-836-7536) today. (templehealth.org)
  • Learn more about our doctors and care team who diagnose and treat pulmonary sarcoidosis. (templehealth.org)
  • Participate in group discussions about sarcoidosis and hear from pulmonary experts. (templehealth.org)
  • Patients are currently being enrolled in the first clinical trial to investigate the efficacy of immunological therapy for chronic pulmonary sarcoidosis. (medicalxpress.com)
  • The current standard treatment for chronic pulmonary sarcoidosis is corticosteroids ," said Adam Morgenthau, MD, principal investigator of the study and Director of the Sarcoidosis Clinic and the Alvin S. Teirstein Sarcoidosis Support Group at Mount Sinai. (medicalxpress.com)
  • Patients with pulmonary sarcoidosis typically exhibit symptoms of shortness of breath, cough and/or wheeze. (medicalxpress.com)
  • That's why Rice, who has pulmonary sarcoidosis (pronounced SAR-COY-DOE-SIS), is taking a lead role in Walgreens' first Sarcoidosis Awareness campaign, taking place Sept. 16-27. (alabamawx.com)
  • In patients treated with repository corticotrophin injection (RCI) for pulmonary sarcoidosis, effective management of adverse events may improve adherence. (ersjournals.com)
  • In the absence of clinical evidence, our Delphi consensus opinions may provide practical guidance to physicians on the management of RCI to treat pulmonary sarcoidosis. (ersjournals.com)
  • In this paper, a modified Delphi method was used to develop an expert consensus on the use of repository corticotrophin injection therapy for pulmonary sarcoidosis, including dosing, concomitant medications, contraindications and adverse event management. (ersjournals.com)
  • For most patients, pulmonary sarcoidosis may be a benign and self-limiting disorder, and spontaneous remission occurs in the majority of patients with asymptomatic disease [ 4 ]. (ersjournals.com)
  • Although the optimal treatment for sarcoidosis remains unclear, corticosteroid therapy has been the mainstay of therapy for those with significantly symptomatic or progressive pulmonary disease or serious extrapulmonary disease [ 10 , 11 ]. (ersjournals.com)
  • Baltzan M, Mehta S, Kirkham TH, Cosio MG. Randomized trial of prolonged chloroquine therapy in advanced pulmonary sarcoidosis. (medscape.com)
  • Thalidomide for improving cutaneous and pulmonary sarcoidosis in patients resistant or with contraindications to corticosteroids. (medscape.com)
  • Russell E, Luk F, Manocha S, Ho T, O'Connor C, Hussain H. Long term follow-up of infliximab efficacy in pulmonary and extra-pulmonary sarcoidosis refractory to conventional therapy. (medscape.com)
  • Evidence for local dendritic cell activation in pulmonary sarcoidosis. (medscape.com)
  • Mechanisms of hypergammaglobulinemia in pulmonary sarcoidosis. (medscape.com)
  • KL-6, surfactant protein A and D in bronchoalveolar lavage fluid from patients with pulmonary sarcoidosis. (medscape.com)
  • Comparative evaluation of serum markers in pulmonary sarcoidosis. (medscape.com)
  • Sarcoidosis (also known as Besnier-Boeck-Schaumann disease) is a disease involving abnormal collections of inflammatory cells that form lumps known as granulomata. (wikipedia.org)
  • Sarcoidosis is a systemic inflammatory disease that can affect any organ, although it can be asymptomatic and is discovered by accident in about 5% of cases. (wikipedia.org)
  • Sarcoidosis of the lung is primarily an interstitial lung disease in which the inflammatory process involves the alveoli, small bronchi, and small blood vessels. (wikipedia.org)
  • Sarcoidosis is a chronic inflammatory disease characterized by a highly focused, exaggerated immune response to an unknown antigen at the target organs. (medscape.com)
  • Sarcoidosis, an inflammatory disease of unknown cause that can affect almost any organ, has been noted in unexpectedly large numbers of World Trade Center (WTC)-exposed persons, including 76 FDNY firefighters. (cdc.gov)
  • Cardiac sarcoidosis is an inflammatory disease that can adversely affect heart function and lead to morbidity and mortality. (auntminnie.com)
  • Sarcoidosis is a multisystem granulomatous inflammatory disease that usually clears on its own. (targetwoman.com)
  • Growth and development of inflammatory cells in small clusters in different areas of the body (a multi-system granulomatous inflammatory disease) is sarcoidosis . (targetwoman.com)
  • Sarcoidosis is a multisystem inflammatory disease, characterized by epitheloid granulomas [ 1 ]. (hindawi.com)
  • Sarcoidosis is an inflammatory disorder of non-caseating granulomas, involving any organ. (asnc.org)
  • Sarcoidosis is an inflammatory disease that causes the formation of tiny clusters of cells, called granulomas, in one or more organs of the body. (uky.edu)
  • Sarcoidosis is a disease or disorder that is specified by the development of small collections of inflammatory cells in different parts of human body, mostly in lungs and lymph nodes, eyes, skin, heart, and other organs. (tutorialspoint.com)
  • Sarcoidosis is an inflammatory disease that can appear in almost any body organ, but most often starts in the lungs or lymph nodes. (aaanativearts.com)
  • Dr. Rohit Gupta joined FOX29 with a patient to bring awareness to sarcoidosis and explain how patients can live with this rare, inflammatory disease. (templehealth.org)
  • Sarcoidosis is a kind of inflammatory disease that affects multiple organs in the body. (planetayurveda.com)
  • The inflammatory process in sarcoidosis leads to formation of noncaseating granulomas and fibrosis in any tissue. (merckmanuals.com)
  • Sarcoidosis is a multisystem disorder of unknown etiology characterized by the formation of inflammatory non-caseating granulomas within affected tissues. (radiopaedia.org)
  • Sarcoidosis is a rare inflammatory disease that can affect any organ but most commonly involves the lungs. (medicalxpress.com)
  • Sarcoidosis is a disease in which abnormal collections of inflammatory cells (granulomas) form in many organs of the body. (msdmanuals.com)
  • Sarcoidosis is characterized by the presence of collections of inflammatory cells (granulomas). (msdmanuals.com)
  • Treatment is the same as for sarcoidosis and includes nonsteroidal anti-inflammatory drugs, including corticosteroids. (msdmanuals.com)
  • Sarcoidosis is an inflammatory disease that affects multiple organs in the body when abnormal masses or nodules consisting of inflamed tissues form in certain organs of the body. (wth.org)
  • To date, there is no curative treatment for sarcoidosis, but only anti-inflammatory drugs limiting the pathologic impact of sarcoidosis in reducing enhanced immunity reactions, granulomatous formation, and their consequences. (medscape.com)
  • Sarcoidosis is a disease due to inflammation. (iaff.org)
  • The goal of therapy in sarcoidosis is to prevent or minimize inflammation and granuloma formation leading to organ system dysfunction, which may ultimately cause end-stage organ destruction by the development of hyaline fibrosis. (medscape.com)
  • One study has shown that the severity of liver function test abnormalities is significantly related with the degree of fibrosis and extensiveness of the granulomatous inflammation in sarcoidosis. (medscape.com)
  • In simple terms sarcoidosis can be defined as a specific type of body tissues inflammation. (targetwoman.com)
  • Treatment aims to alleviate specific symptoms and resolve the underlying inflammation that causes sarcoidosis. (uky.edu)
  • It has been found that environmental antigens and pollutants can also trigger the inflammation or the response leading to sarcoidosis. (tutorialspoint.com)
  • Sarcoidosis is a rare disease that causes inflammation and scar tissue throughout the body, especially the lungs, lymph nodes, liver, skin, and eyes. (peacehealth.org)
  • ABSTRACT: Granulomatous inflammation of the uterus is rare, and sarcoidosis involving the uterus is even less common. (scirp.org)
  • We report here a case of granulomatous inflammation involving a leiomyoma in a patient with a previous clinical diagnosis of sarcoidosis. (scirp.org)
  • The recipes that Chrystal talks about are Sesame Avocado Chicken Salad and Quinoa Salad, both of which have ingredients that help with inflammation and can help reduce the symptoms of Sarcoidosis. (wth.org)
  • Sarcoidosis and tuberculoid leprosy (TL) are prototypes of granulomatous inflammation in dermatology , which embody one of the histopathology limitations in distinguishing some diseases . (bvsalud.org)
  • The diagnosis of sarcoidosis is established when histopathologic evidence of noncaseating granulomata in affected organs and reasonable exclusion of other granulomatous diseases support compatible clinical and radiographic findings. (medscape.com)
  • The inclusion criteria were a diagnosis of sarcoidosis, age 18 years and above, and the willingness to take part in the study. (hindawi.com)
  • 9-14 However, the reports to date have not always provided clear clinical evidence supporting the diagnosis of sarcoidosis nor have they excluded patients with prior tuberculous disease or infection. (bmj.com)
  • In addition, formalin fixed paraffin embedded tissue was obtained from eight patients with an earlier diagnosis of sarcoidosis who were still being followed up. (bmj.com)
  • The objective of the current study was to assess the yield of endoscopic ultrasound (EUS)-guided fine-needle aspiration (FNA) for the diagnosis of sarcoidosis in a large patient group. (ersjournals.com)
  • EUS-FNA demonstrated noncaseating granulomas without necrosis in 41 of 50 patients (82%) with the final diagnosis of sarcoidosis. (ersjournals.com)
  • The current authors expect that endoscopic ultrasound-guided fine-needle aspiration will reduce the number of mediastinoscopies for the diagnosis of sarcoidosis dramatically. (ersjournals.com)
  • In total, 51 consecutive patients with the differential diagnosis of sarcoidosis were included in this study. (ersjournals.com)
  • The diagnosis of sarcoidosis with oesophageal involvement was made and treatment with prednisolone 30 mg OD initiated. (bmj.com)
  • This was the patient's first tissue-based diagnosis of sarcoidosis and highlighted the importance of adequate sampling of routine surgical specimens, as they may harbor signs of systemic disease. (scirp.org)
  • [ 48 ] Whole-body FDG-PET scanning is of value in identifying occult and reversible granulomas in patients with sarcoidosis. (medscape.com)
  • It may still be helpful in a subset of patients in whom the clinical picture remains confusing despite histologic evidence of noncaseating granulomas (NCGs) (eg, differentiating chronic hypersensitivity pneumonitis from sarcoidosis). (medscape.com)
  • Sarcoidosis is a disease that leads to tiny lumps (called granulomas) developing in and on your body. (lunguk.org)
  • The most common areas for granulomas to grow are the lungs, lymph nodes, eyes, and skin, but sarcoidosis can affect any organ or area of the body. (templehealth.org)
  • In people with Sarcoidosis, nodules or abnormal masses called granulomas may alter the normal structure and functions of affected organ. (planetayurveda.com)
  • Our immune system protects us from foresight bacteria and virus and other substances but in Sarcoidosis our immune cells get collected in the form of granulomas in particular organ of body and produce the symptoms. (planetayurveda.com)
  • In a preliminary report in patients with suspected sarcoidosis, EUS-FNA has also been shown to be accurate in demonstrating noncaseating granulomas 13 . (ersjournals.com)
  • We use SHG images to analyze the collagen network, to distinguish differences between sarcoidosis and TL granulomas . (bvsalud.org)
  • The results may indicate insufficient differentiating power for most tested FOS and GLCM parameters in classifying sarcoidosis and TL granulomas , when used individually. (bvsalud.org)
  • The aims of this study were (a) to determine the degree of EDS in sarcoidosis patients in comparison with the general population and to test psychometric properties of the ESS in a large sample of sarcoidosis patients, (b) to analyze the impact of affected organs and concomitant diseases on EDS, and (c) to investigate associations between daytime sleepiness and QoL. (hindawi.com)
  • What is PET/MRI's value for cardiac sarcoidosis? (auntminnie.com)
  • While the hybrid modality's range of clinical applications appears expansive, the authors of an editorial published online February 7 in the Journal of Nuclear Cardiology pose the opinion that it might be time to pump the brakes on wider use of PET/MRI, at least in cases of cardiac sarcoidosis. (auntminnie.com)
  • A December 2015 study by Hanneman et al found that when paired with MRI, PET achieved positive results for cardiac sarcoidosis for all eight patients (100%), compared with only four patients (50%) with PET/CT. (auntminnie.com)
  • Notable beneficiaries would include young patients with cardiac sarcoidosis who face a series of imaging scans. (auntminnie.com)
  • On the other hand, many cardiac sarcoidosis patients have implantable cardiac devices (ICDs). (auntminnie.com)
  • The true generalizability of hybrid PET/MRI for cardiac sarcoidosis, therefore, remains in question," they added. (auntminnie.com)
  • Although the potential benefits are undeniable, the practical value in patients with suspected or confirmed cardiac sarcoidosis is yet to be determined. (auntminnie.com)
  • PET/MRI scans are more accurate for diagnosing cardiac sarcoidosis than established imaging approaches, as well as reduces patient radiation and imaging times. (auntminnie.com)
  • Diagnosis of cardiac sarcoidosis (CS) can often be challenging with no clear diagnostic gold standard. (asnc.org)
  • 1 Diagnosis of CS currently relies mainly on clinical criteria published by Japanese Ministry of Health and Heart Rhythm Society, both of which require a proven histologic or clinical diagnosis of extra-cardiac sarcoidosis along with clinical criteria mentioned above and/or imaging evidence of CS by cardiac magnetic resonance imaging (CMR) or F-18- Flouro dexoy glucose positron emission tomography (FDG PET). (asnc.org)
  • However, diagnosis of isolated cardiac sarcoidosis using these diagnostic criteria or with endomyocardial biopsy can be challenging. (asnc.org)
  • If performed well, it provides diagnostic quality images in patients with implantable cardiac devices or severe renal dysfunction, and also allows whole body imaging which can help identify foci of extra-cardiac sarcoidosis. (asnc.org)
  • In cardiac sarcoidosis, the conducting system and/or myocardium are typically involved in patients with clinically apparent cardiac sarcoidosis, but valvular, papillary muscle, and pericardial involvement may also occur. (merckmanuals.com)
  • Nearly all patients with cardiac sarcoidosis have involvement of other organs (typically the lungs), but cardiac sarcoidosis may rarely occur in isolation. (merckmanuals.com)
  • The predilection of cardiac sarcoid involvement of the interventricular septum causes atrioventricular (AV) conduction system blocks in many patients with cardiac sarcoidosis. (merckmanuals.com)
  • Most patients with cardiac sarcoidosis are asymptomatic, but the associated bradyarrhythmias and tachyarrhythmias may cause palpitations, syncope, and sometimes cardiac arrest or sudden death. (merckmanuals.com)
  • Corticosteroids remain the cornerstone for the treatment of sarcoidosis particularly at induction with a rapid response in most patients and the potential occurrence of adverse events. (medscape.com)
  • citation needed] Treatments for sarcoidosis include corticosteroids and immunosuppressive drugs. (wikipedia.org)
  • Indeed, it is the most common fibrotic lung disorder and occurs often enough in the United States for Congress to have declared a National Sarcoidosis Awareness Day in 1990. (iaff.org)
  • Lung sarcoidosis results in shortness of breath and unrelenting dry cough. (targetwoman.com)
  • METHODS Fresh tissue samples (node or lung biopsy) taken from 23 patients with newly diagnosed sarcoidosis, 10 with other respiratory disease, and four patients with culture positive tuberculosis were analysed using PCR to amplify a 123 bp fragment of IS6110, the insertion element present in MTb, and nested PCR to further amplify an 85 bp sequence within the 123 bp product. (bmj.com)
  • CONCLUSIONS This study has shown the absence of MTb DNA in lymph node and lung biopsy samples from patients with sarcoidosis. (bmj.com)
  • Sarcoidosis involves a high risk of cancer in some organs like lung, liver, stomach and of melanoma and lymphoma as well. (tutorialspoint.com)
  • Bronchoscopy with transbronchial lung biopsy (TBLB) is nondiagnostic in 30% of patients with suspected sarcoidosis and has a risk of pneumothorax and haemoptysis. (ersjournals.com)
  • Sarcoidosis is a systemic disease of unknown cause characterized by the formation of granulomatous lesions in involved organs, usually with lung and lymphatic involvement. (medscape.com)
  • You can also learn more from our partner organization the Foundation for Sarcoidosis Research (FSR) . (lung.org)
  • Pulmonologist Dr. Joseph Barney of UAB Hospital, which is a founding member of the Foundation for Sarcoidosis Research (FSR) Global Sarcoidosis Clinic Alliance (GSCA). (alabamawx.com)
  • Sarcoidosis is a systemic granulomatous disease that is relatively rare in children. (medscape.com)
  • Sarcoidosis, a systemic, granulomatous disease, can occur in adult and pediatric patients, but it is nonetheless relatively rare in children. (medscape.com)
  • About 25% of patients with systemic sarcoidosis have cardiac involvement identifiable using imaging techniques, but cardiac involvement is symptomatic in only about 20% of these (5% of all patients with sarcoidosis). (merckmanuals.com)
  • A significant number of deaths resulting from systemic sarcoidosis are due to sudden cardiac death, including in many patients who have had no previous indication of cardiac involvement. (merckmanuals.com)
  • Localization to the lungs is by far the most common manifestation of sarcoidosis. (wikipedia.org)
  • 2.) Chronic sarcoidosis causes scarring (fibrosis) of the lungs that gets worse over time. (lunguk.org)
  • Most commonly Sarcoidosis occurs in lungs, skin, eyes and lymph nodes. (planetayurveda.com)
  • [ 1 , 52 ] Considering its prognostic significance, the heart rate recovery index may have clinical use in identifying patients with sarcoidosis who are at high risk for ventricular arrhythmias and sudden death. (medscape.com)
  • This project is a detailed re-examination of this group, to define their clinical patterns and genetic markers and compare them with those of previously reported non-WTC-exposed sarcoidosis patients. (cdc.gov)
  • Sarcoidosis is a non-caseating granulomatous multisystem disease with a wide range of clinical and radiographic manifestations. (radiopaedia.org)
  • The randomized placebo Phase II clinical trial at Mount Sinai for patients with sarcoidosis is designed to assess the safety, tolerability and efficacy of an antibody directed against macrophage colony-stimulating factor (m-CSF), a protein associated with the development of sarcoidosis. (medicalxpress.com)
  • Of these, the clinical features of sarcoidosis are most similar to the characteristics of CBD ( Table 3 ). (cdc.gov)
  • No curative treatment for sarcoidosis is known, and in many cases, the condition resolves on its own. (uky.edu)
  • What are the symptoms of sarcoidosis? (lunguk.org)
  • Symptoms of sarcoidosis depend upon the organ affected. (targetwoman.com)
  • Because the symptoms of sarcoidosis can be very similar to those of other medical conditions, your first visit will include a careful review of your symptoms, your personal and family medical history, and your lifestyle habits. (uky.edu)
  • Some of the common symptoms of sarcoidosis include night sweats, enlarged lymph nodes as well as lymph glands, short breath and wheezing. (tutorialspoint.com)
  • Generally, shortness of breath and a cough that will not go away are among the first symptoms of sarcoidosis. (aaanativearts.com)
  • The presenting manifestation of sarcoidosis was neurological in 16 (48%) of them. (nih.gov)
  • This included 24 patients with facial nerve palsy as the only manifestation of neurological sarcoidosis in whom complete recovery was seen in all but 1 patient. (nih.gov)
  • Skin manifestation of sarcoidosis characterized by large bluish-red nodules and plaques occurring on the nose, cheeks, ears, fingers and hands. (dermis.net)
  • Heerfordt syndrome is a rare manifestation of sarcoidosis. (wikipedia.org)
  • It was originally attributed to mumps, but after further studies by Swedish doctor Jan G. Waldenström in 1937, it was classified as a distinct manifestation of sarcoidosis. (wikipedia.org)
  • Sarcoidosis occurs all over the world in all ages and races. (radiopaedia.org)
  • Sarcoidosis was first described in 1877 by the English doctor Jonathan Hutchinson as a non-painful skin disease. (wikipedia.org)
  • Sarcoidosis was originally called Hutchinson's disease or Boeck's disease. (iaff.org)
  • Sarcoidosis was once considered a rare disease. (iaff.org)
  • Basic facts about sarcoidosis, including its signs and symptoms, how it affects breathing, and ways to manage the disease after a diagnosis. (nih.gov)
  • Neurological disease was identified in 71 of 554 patients with sarcoidosis. (nih.gov)
  • Sarcoidosis is a relatively rare disease. (lunguk.org)
  • Sarcoidosis is a rare disease where small lumps form in the body. (epnet.com)
  • Sarcoidosis is also known as sarcoid or Besnier-Boeck disease . (targetwoman.com)
  • Sarcoidosis can affect young women more than it does men and is no longer a considered a rare disease. (targetwoman.com)
  • If you have sarcoidosis, you may need to work with doctors and specialists in different areas of healthcare to manage your disease and symptoms. (lung.org)
  • RESULTS MTb DNA was not detected in any of the tissue samples from patients with sarcoidosis or other respiratory disease but was found in all four patients with tuberculosis. (bmj.com)
  • The aim of this study was to collect prospectively tissue from a carefully characterised cohort of patients with newly diagnosed sarcoidosis in whom tuberculous infection or prior disease had been excluded and to use PCR to search for DNA sequences specific for MTb. (bmj.com)
  • Once considered a rare disease, sarcoidosis is now known to be a common chronic illness that appears all over the world. (aaanativearts.com)
  • Key consensus recommendations included a starting dose of 40 units twice a week for patients with less severe disease, continued at a maintenance dose for patients who responded, particularly those with chronic refractory sarcoidosis. (ersjournals.com)
  • We are looking to recruit a genetic specialist in the Group of Johan Grunewald in the Respiratory Medicine Division to work on sarcoidosis projects to explore genetic variation across population ancestries associated with disease risk and sarcoidosis target organ phenotypes. (varbi.com)
  • Darier-Roussy disease Sarcoidosis List of cutaneous conditions Rapini, Ronald P. (wikipedia.org)
  • TNF inhibitors are considered in severe refractory sarcoidosis. (medscape.com)
  • The results should help to determine the extent and severity of sarcoidosis triggered by a unique occupational exposure. (cdc.gov)
  • But, if you have sarcoidosis you can be reassured that patients with sarcoidosis are usually asymptomatic or have mild symptoms. (iaff.org)
  • As many as one-half of patients with sarcoidosis are asymptomatic. (luc.edu)
  • Honore, L.H. (1981) Asymptomatic Genital Sarcoidosis. (scirp.org)
  • Computed tomography of the chest can suggest intrathoracic sarcoidosis, but diagnosis relies on cardiac MRI and/or 18 F-fluorodeoxyglucose positron emission tomography ( 18 F-FDG-PET). (acc.org)
  • CONCLUSIONS--In all of these cases a diagnosis of FHU may represent a specific secondary ocular response to sarcoidosis rather than a primary idiopathic uveitis syndrome. (bmj.com)
  • People suffering from sarcoidosis should meet their physician on a regular basis and take regular follow-up checkups so as to avoid any future complications. (targetwoman.com)
  • What could be the Complications of Sarcoidosis? (planetayurveda.com)
  • Sarcoidosis is a multisystem granulomatous disorder of unknown cause [ 1 , 2 ]. (ersjournals.com)
  • The presentation in sarcoidosis can vary widely, depending on the extent and severity of organ involvement. (medscape.com)
  • Neurological involvement is a significant cause of morbidity and mortality in patients with sarcoidosis. (nih.gov)
  • Coexistent meningeal or hypothalamic involvement is often present, but extracranial sarcoidosis may be absent. (neurology.org)
  • Since chest x-rays are readily available and have a low radiation burden, the pattern of nodal and parenchymal involvement is typically used to 'stage' sarcoidosis ( chest x-ray staging of sarcoidosis ) 3 . (radiopaedia.org)
  • Oesophageal involvement of sarcoidosis is extremely rare and only a few cases have been reported. (bmj.com)
  • BACKGROUND Although some studies have reported the presence of Mycobacterium tuberculosis (MTb) DNA in tissues affected by sarcoidosis, the data are conflicting. (bmj.com)
  • The aim of this study was to collect prospectively tissue from patients with sarcoidosis in whom tuberculosis had been excluded, and to use polymerase chain reaction (PCR) to search for DNA sequences specific for MTb. (bmj.com)
  • Mycobacterium tuberculosis (MTb) has long been a likely contender as the inciting antigen in sarcoidosis, although Koch's postulates have never been fulfilled. (bmj.com)
  • In patients with suspected sarcoidosis a tissue diagnosis is strongly recommended to exclude malignant diseases or tuberculosis, especially when treatment is considered 1 . (ersjournals.com)
  • Sarcoidosis can affect almost any organ so there are a large range of possible symptoms. (lunguk.org)
  • The effects of sarcoidosis vary from person to person depending on the organ affected. (targetwoman.com)
  • Symptoms for sarcoidosis are specific to the organ or tissue affected. (targetwoman.com)
  • If sarcoidosis affects more than one organ, you may need longer treatment or combinations of medication. (lung.org)
  • Myocardial sarcoidosis unresponsive to steroids. (medscape.com)
  • Our interest in immunosuppressive agents for chronic sarcoidosis has given us experience with various agents for the treatment of sarcoidosis, including cyclophosphamide and methotrexate. (nih.gov)
  • Planet Ayurveda provides best combination of effective herbal remedies such as Sarco Care Pack for ayurvedic treatment of sarcoidosis. (planetayurveda.com)
  • Treatment of sarcoidosis with infliximab. (medscape.com)
  • Sarcoidosis can be diagnosed through a biopsy of the lymph nodes or lymph glands along with chest-X rays. (tutorialspoint.com)
  • Sarcoidosis can affect any part of the heart ranging from the heart muscle, valves and the layers of tissue that cover the heart to the heart's electrical signaling system. (targetwoman.com)
  • DNA was also extracted from formalin fixed tissue from eight additional patients with sarcoidosis. (bmj.com)
  • Some investigators have found evidence of MTb in tissues using the polymerase chain reaction (PCR) to amplify mycobacterial DNA or rRNA 6-8 but more recent studies have failed to identify such organisms in the majority of tissue samples from patients with sarcoidosis. (bmj.com)
  • Fresh tissue samples were prospectively collected from a cohort of 23 patients with newly diagnosed sarcoidosis all seen at one outpatient clinic at one hospital. (bmj.com)
  • Neurological symptoms can be significant manifestations of sarcoidosis. (nih.gov)
  • Two skin doctors working independently, Dr. Jonathan Hutchinson and Dr. Caesar Boeck in Norway, first identified sarcoidosis over 100 years ago. (iaff.org)
  • The description of sarcoidosis goes back to 1899, when Caesar Boeck described the skin nodules characterized by epithelioid cells with large, pale nuclei and giant cells as "multiple benign sarcoid of skin," due to its resemblance to sarcoma. (medscape.com)
  • Chest radiograph showing bilateral hilar lymphadenopathy in a 10-year-old girl with sarcoidosis. (medscape.com)
  • As intrathoracic lymphadenopathy is common in sarcoidosis, with radiographic evidence of hilar node enlargement in up to 90% of patients 1 , lymph nodes (LNs) are a likely target to confirm the diagnosis. (ersjournals.com)
  • The pathophysiology of chronic sarcoidosis is poorly understood, and is an important gap in our understanding of sarcoidosis. (jefferson.edu)
  • Muller-Quernheim J, Kienast K, Held M, Pfeifer S, Costabel U. Treatment of chronic sarcoidosis with an azathioprine/prednisolone regimen. (medscape.com)
  • Cyclosporine and chronic sarcoidosis. (medscape.com)
  • Thalidomide for chronic sarcoidosis. (medscape.com)
  • The anergic state in sarcoidosis is associated with diminished dendritic cell function. (cdc.gov)
  • The aetiology of sarcoidosis remains unclear 100 years after its first description, although ample evidence supports an antigen driven immunopathogenic process. (bmj.com)
  • 1.) Acute sarcoidosis (sometimes called Lofgren's syndrome) can flare up quickly. (lunguk.org)
  • In most cases acute sarcoidosis goes away without treatment. (lunguk.org)
  • Healthy lifestyle habits are important following an episode of acute sarcoidosis. (uky.edu)
  • We will also assess genetic differences with similarly WTC-exposed firefighters who did not develop sarcoidosis. (cdc.gov)
  • Fuchs' heterochromic uveitis and sarcoidosis. (bmj.com)
  • In patients that have already been diagnosed with sarcoidosis, Heerfordt syndrome can be inferred from the major symptoms of the syndrome, which include parotitis, fever, facial nerve palsy and anterior uveitis. (wikipedia.org)
  • The cause for sarcoidosis is yet to be identified therefore prognosis of the condition is not an easy task. (targetwoman.com)
  • Sarcoidosis typically develops between the ages of 20 and 40 years. (msdmanuals.com)
  • Zic JA, Horowitz DH, Arzubiaga C, King LE Jr. Treatment of cutaneous sarcoidosis with chloroquine. (medscape.com)
  • Many people with sarcoidosis have no symptoms, and the disorder is discovered on a chest x-ray that is taken for other reasons. (msdmanuals.com)
  • In a small number of cases sarcoidosis affects more than one person in the same family. (lunguk.org)
  • Sarcoidosis very rarely affects children. (lunguk.org)
  • Bones and jointsYou can get pain in any joint but sarcoidosis most commonly affects your knees and ankles. (lunguk.org)
  • Sarcoidosis in the nervous system only affects a small number of people. (lunguk.org)
  • Sarcoidosis affects the heart in 5 to 25% of sarcoidosis cases. (targetwoman.com)
  • Depression and anxiety affects many people with any illness, including sarcoidosis. (lung.org)
  • Mount Sinai Health System offers expert sarcoidosis services at these metropolitan New York locations. (mountsinai.org)
  • Mount Sinai is a National Institutes of Health Center of Excellence for research in sarcoidosis. (medicalxpress.com)
  • Sarcoidosis patients suffer from a broad spectrum of symptoms such as muscle pain, weight loss, fever, night sweats, cough, breathlessness, and reduced exercise capacity, which results in reduced quality of life (QoL) [ 2 , 3 ]. (hindawi.com)
  • It is not unusual, however, for sarcoidosis symptoms to be more general: weight loss, fatigue, night sweats, fever or an overall feeling of ill health. (aaanativearts.com)