A progressive neurodegenerative condition of the central and autonomic nervous systems characterized by atrophy of the preganglionic lateral horn neurons of the thoracic spinal cord. This disease is generally considered a clinical variant of MULTIPLE SYSTEM ATROPHY. Affected individuals present in the fifth or sixth decade with ORTHOSTASIS and bladder dysfunction; and later develop FECAL INCONTINENCE; anhidrosis; ATAXIA; IMPOTENCE; and alterations of tone suggestive of basal ganglia dysfunction. (From Adams et al., Principles of Neurology, 6th ed, p536)
Mechanical devices used to produce or assist pulmonary ventilation.
A characteristic symptom complex.
Discomfort and partial inhibition of the usual forms of behavior when in the presence of others.
A syndrome complex composed of three conditions which represent clinical variants of the same disease process: STRIATONIGRAL DEGENERATION; SHY-DRAGER SYNDROME; and the sporadic form of OLIVOPONTOCEREBELLAR ATROPHIES. Clinical features include autonomic, cerebellar, and basal ganglia dysfunction. Pathologic examination reveals atrophy of the basal ganglia, cerebellum, pons, and medulla, with prominent loss of autonomic neurons in the brain stem and spinal cord. (From Adams et al., Principles of Neurology, 6th ed, p1076; Baillieres Clin Neurol 1997 Apr;6(1):187-204; Med Clin North Am 1999 Mar;83(2):381-92)
A medical specialty concerned with the use of physical agents, mechanical apparatus, and manipulation in rehabilitating physically diseased or injured patients.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Treatment for individuals with speech defects and disorders that involves counseling and use of various exercises and aids to help the development of new speech habits.
Skilled treatment that helps individuals achieve independence in all facets of their lives. It assists in the development of skills needed for independent living.
Acquired or developmental conditions marked by an impaired ability to comprehend or generate spoken forms of language.

Novel therapeutic strategy against central baroreflex failure: a bionic baroreflex system. (1/54)

BACKGROUND: Central baroreflex failure in Shy-Drager syndrome and traumatic spinal cord injuries results in severe orthostatic hypotension and often confines the patient to the bed. We proposed a novel therapeutic strategy against central baroreflex failure: implementation of an artificial feedback control system able automatically to regulate sympathetic vasomotor tone, that is, a bionic baroreflex system (BBS). With the use of a rat model of central baroreflex failure, we developed the BBS and tested its efficacy. METHODS AND RESULTS: Our prototype BBS for the rat consisted of a pressure sensor placed into the aortic arch, stimulation electrodes implanted into the greater splanchnic nerve, and a computer-driven neural stimulator. By a white noise approach for system identification, we first estimated the dynamic properties underlying the normal baroreflex control of systemic arterial pressure (SAP) and then determined how the BBS computer should operate in real time as the artificial vasomotor center to mimic the dynamic properties of the native baroreflex. The open-loop transfer function of the artificial vasomotor center was identified as a high-pass filter with a corner frequency of 0.1 Hz. We evaluated the performance of the BBS in response to rapid-progressive hypotension secondary to sudden sympathetic withdrawal evoked by the local imposition of a pressure step on carotid sinus baroreceptors in 16 anesthetized rats. Without the BBS, SAP rapidly fell by 49+/-8 mm Hg in 10 seconds. With the BBS placed on-line with real-time execution, the SAP fall was suppressed by 22+/-6 mm Hg at the nadir and by 16+/-5 mm Hg at the plateau. These effects were statistically indistinguishable from those of the native baroreflex system. CONCLUSIONS: These results suggest the feasibility of a BBS approach for central baroreflex failure.  (+info)

Diurnal blood pressure variation in progressive autonomic failure. (2/54)

To investigate the role of the autonomic nervous system (ANS) in the generation of the circadian blood pressure (BP) variation, the degree of impairment of the ANS was related to the results of ambulatory BP recordings in 212 patients with progressive autonomic failure due to familial amyloid polyneuropathy. On the basis of BP and/or heart rate (HR) responses to the Valsalva maneuver, 60 degrees head-up tilting, deep-breathing tests, and plasma norepinephrine levels, 4 groups of patients were distinguished. In all patients and in 38 age-matched control subjects, ambulatory BP was monitored. Patients of group I (n=40, aged 32+/-3 y), with no evidence yet of impairment of their ANS, had circadian BP and HR variations indistinguishable from controls. Patients of group II (n=41, aged 34+/-5 y) had a variable degree of impairment of their parasympathetic ANS, but their sympathetic ANS was still intact. Twenty-four-hour HR was higher in these patients than in controls (88+/-11 versus 78+/-7 bpm, P<0.01). Their circadian HR variation was maintained, but their circadian BP variation was diminished (10+/-6/11+/-4 versus 17+/-6/16+/-4 mm Hg in controls, P<0.01) because of an attenuation of the nocturnal BP decline. Patients of group III (n=69, aged 36+/-6 y), with parasympathetic failure and intermediate sympathetic dysfunction, had a blunted diurnal BP variation, whereas patients of group IV (n=62, aged 38+/-6 y), with parasympathetic failure and severe sympathetic dysfunction, had an absent diurnal BP variation. In patients of groups III and IV, a decrease in daytime BP accounted for the blunted circadian BP variation. This extensive study in progressive autonomic failure confirms the important role of the ANS in the generation of circadian BP variation. For the maintenance of a normal circadian BP pattern, not only an intact sympathetic but also an intact afferent parasympathetic ANS is a prerequisite.  (+info)

Recognizing and treating diabetic autonomic neuropathy. (3/54)

Diabetic autonomic neuropathy can cause heart disease, gastrointestinal symptoms, genitourinary disorders, and metabolic disease. Strict glycemic control can slow the onset of diabetic autonomic neuropathy and sometimes reverse it. Pharmacologic and nonpharmacologic therapies are available to treat symptoms.  (+info)

Catechol-o-methyltransferase and blood pressure in humans. (4/54)

BACKGROUND: Whether catechol-O-methyltransferase (COMT), the enzyme that metabolizes extraneuronal norepinephrine, contributes to blood pressure regulation in humans is unknown. METHODS AND RESULTS: We studied incremental doses of the COMT inhibitor entacapone, the sympathetic stimulant yohimbine, and placebo in 7 patients with multiple system atrophy (Shy Drager syndrome). We selected these unique subjects because norepinephrine exerts an exaggerated increase in blood pressure in these patients. Autonomic regulation was characterized with intravenous phenylephrine, nitroprusside, and trimethaphan. Patients were extremely hypersensitive to phenylephrine and nitroprusside. Trimethaphan elicited a profound depressor response. Phenylephrine sensitivity increased only slightly during ganglionic blockade. Entacapone increased systolic blood pressure dose-dependently; however, the pressor response to yohimbine was approximately 3.5 times greater than the maximal response to entacapone. CONCLUSIONS: COMT inhibition elicits a moderate, dose-dependent pressor response in the setting of severely impaired baroreflex buffering. Patients with multiple system atrophy allow for the characterization of subtle manipulations of norepinephrine turnover and blood pressure regulation in small numbers of subjects.  (+info)

Modulation of QT interval during autonomic nervous system blockade in humans. (5/54)

BACKGROUND: It is thought that the autonomic nervous system modulates QT interval, but traditional autonomic blockade combining propranolol and atropine has produced conflicting results. We used the alternative approach of interrupting neurotransmission at the level of autonomic ganglia to determine its effect on the QT interval. METHODS AND RESULTS: We infused trimethaphan at increasing doses (0.5 to 10 mg/min IV) while monitoring heart rate, heart rate variability spectra, QT interval, and blood pressure in 10 normal volunteers, 9 patients with multiple system atrophy (MSA), and 8 patients with pure autonomic failure (PAF). The QT interval was corrected for heart rate using Bazett's formula (QTc). Patients with PAF had very low heart rate variability and a prolonged QTc at baseline (465+/-8 ms) compared with patients with MSA (448+/-6 ms) and normal subjects (432+/-6 ms). In normal subjects, trimethaphan dose-dependently prolonged QTc (to 469+/-7 ms), decreased RR interval (995+/-45 to 670+/-35 ms), and abolished heart rate variability. In MSA patients, trimethaphan also prolonged QTc (to 463+/-7 ms) and reduced heart rate variability but did not significantly change RR interval (from 813+/-38 to 801+/-39). CONCLUSIONS: Autonomic blockade prolongs QT interval in normal subjects to a similar duration as in PAF patients. Furthermore, blocking residual autonomic tone in PAF patients is associated with a further increase in QT interval length. Patients with MSA have greater residual sympathetic tone and greater prolongation of the QT interval during ganglionic blockade than PAF patients.  (+info)

Autonomic control after blockade of the norepinephrine transporter: a model of orthostatic intolerance. (6/54)

Orthostatic intolerance is a debilitating syndrome characterized by tachycardia on assumption of upright posture. The norepinephrine (NE) transporter (NET) has been implicated in a genetic form of the disorder. We assessed the combined central and peripheral effects of pharmacological NET blockade on cardiovascular regulation and baroreflex sensitivity in rats. NE reuptake was blocked chronically in female Sprague-Dawley rats by the NET antagonist desipramine (DMI). Treated animals demonstrated an elevated supine heart rate, reduced tyramine responsiveness, and a reduced plasma ratio of the intraneuronal NE metabolite dihydroxyphenylglycol relative to NE, all of which are consistent with observations in human NET deficiency. Spectral analysis revealed a dramatic decrease in low-frequency spectral power after DMI that was consistent with decreased sympathetic outflow. Stimulation of the baroreflex with the vasodilator nitroprusside revealed an attenuated tachycardia in DMI-treated animals. This indicated that the DMI-induced sympathoinhibitory effects of increased NE in the brain stem predominates over the functional elevation of NE stimulation of peripheral targets. Thus attenuated baroreflex function and reduced sympathetic outflow may contribute to the orthostatic intolerance of severe NET deficiency.  (+info)

The effects of water ingestion on orthostatic hypotension in two groups of chronic autonomic failure: multiple system atrophy and pure autonomic failure. (7/54)

BACKGROUND: Oral ingestion of water increases seated blood pressure in patients with chronic autonomic failure by mechanisms that remain unclear. As orthostatic hypotension is common in chronic autonomic failure, and is not always adequately controlled by medication, the potential benefits of water ingestion on standing blood pressure were studied in two types of autonomic failure: multiple system atrophy (MSA), in which the lesion is central and pre-ganglionic, and pure autonomic failure (PAF), in which the lesion is post-ganglionic. METHODS: In 14 patients with autonomic failure (seven PAF and seven MSA) standing blood pressure and heart rate were measured before, and 15 and 35 minutes after ingestion of 480 ml distilled water. Patients remained seated for 15 minutes after water ingestion, with beat to beat cardiovascular indices measured with the Portapres II device with subsequent Modelflow analysis. RESULTS: Standing prior to water ingestion caused a significant fall in blood pressure in all patients. After water ingestion there was a rise in seated blood pressure. Seated and standing blood pressure at 15 and 35 minutes after water ingestion was significantly higher than before water, with an improvement in orthostatic symptoms. The time to first significant rise in seated blood pressure occurred at 5 minutes post water ingestion in PAF and at 13 minutes in MSA. These increases were accompanied by increases in total peripheral resistance, reaching significance by 5 minutes in PAF and 13 minutes in MSA. There were no significant changes in cardiac output, stroke volume, or ejection fraction. CONCLUSIONS: Water is thus beneficial in improving standing BP in AF, acting within 15 minutes in both MSA and PAF. The earlier onset of the pressor effect in PAF may reflect the differing lesion site and underlying pathophysiology between these conditions.  (+info)

Cardiac and extracardiac sympathetic denervation in Parkinson's disease with orthostatic hypotension and in pure autonomic failure. (8/54)

The uptake of 6-(18)F-fluorodopamine by cardiac noradrenergic nerves enables visualization of the sympathetic innervation of the left ventricular myocardium by PET. Patients with Parkinson's disease (PD) and orthostatic hypotension (OH) (PD+OH) or with pure autonomic failure (PAF) have markedly decreased myocardial 6-(18)F-fluorodopamine-derived radioactivity, consistent with cardiac sympathetic denervation, a phenomenon that neurochemical, neuropharmacologic, and, most recently, postmortem neuropathologic studies have confirmed. In this study, we examined whether 6-(18)F-fluorodopamine can visualize sympathetic innervation in extracardiac organs and, if so, whether patients with PD+OH or PAF have neuroimaging evidence of extracardiac noradrenergic denervation. METHODS: To validate the method, healthy volunteers underwent 6-(18)F-fluorodopamine scanning of the head, thorax, and abdomen, with or without treatment with desipramine to block sympathoneural uptake of catecholamines. (13)N-Ammonia scanning was used to address possible group differences in 6-(18)F-fluorodopamine delivery by blood perfusion. RESULTS: Desipramine treatment was associated with decreased 6-(18)F-fluorodopamine-derived radioactivity in the heart, renal cortex, and thyroid gland but not in the liver, spleen, renal pelvis, or salivary glands. Both the PD+OH group and the PAF group had decreased 6-(18)F-fluorodopamine-derived radioactivity in the heart (P < 0.0001) and renal cortex (P = 0.02 and P = 0.005, respectively). The PD+OH group also had decreased radioactivity in the thyroid gland (P = 0.01). Neither group had decreased radioactivity in the other organs, after correction for (13)N-ammonia-derived radioactivity. CONCLUSION: 6-(18)F-Fluorodopamine scanning visualizes sympathetic innervation in the heart, renal cortex, and thyroid gland. Both PD+OH and PAF involve decreased noradrenergic innervation that is most prominent in the heart but is also detectable in extracardiac organs.  (+info)

Shy-Drager syndrome (SDS) is a rare and progressive neurodegenerative disorder that affects the autonomic nervous system (ANS). The ANS controls involuntary bodily functions such as heart rate, blood pressure, sweating, digestion, and pupil dilation. SDS is also known as multiple system atrophy with orthostatic hypotension or Bradbury-Eggleston syndrome.

SDS is characterized by a combination of symptoms related to the dysfunction of the autonomic nervous system, including:

1. Orthostatic hypotension (a sudden drop in blood pressure upon standing)
2. Autonomic failure (manifesting as erectile dysfunction, urinary retention or incontinence, and gastrointestinal disturbances)
3. Parkinsonian features (tremors, rigidity, bradykinesia, and postural instability)
4. Respiratory abnormalities (breathing difficulties, especially during sleep)
5. Ocular symptoms (abnormal pupil dilation and convergence insufficiency)
6. Smooth muscle atrophy (leading to reduced bladder capacity and gastrointestinal motility issues)

The underlying cause of Shy-Drager syndrome is the degeneration of nerve cells in specific areas of the brain, particularly within the autonomic nervous system centers. The exact etiology remains unclear; however, it is believed to involve a combination of genetic and environmental factors. There is no known cure for SDS, and treatment primarily focuses on managing symptoms and improving quality of life.

Mechanical Ventilators are medical devices that assist with breathing by providing mechanical ventilation to patients who are unable to breathe sufficiently on their own. These machines deliver breaths to the patient through an endotracheal tube or a tracheostomy tube, which is placed in the windpipe (trachea). Mechanical Ventilators can be set to deliver breaths at specific rates and volumes, and they can also be adjusted to provide varying levels of positive end-expiratory pressure (PEEP) to help keep the alveoli open and improve oxygenation.

Mechanical ventilation is typically used in critical care settings such as intensive care units (ICUs), and it may be employed for a variety of reasons, including respiratory failure, sedation, neuromuscular disorders, or surgery. Prolonged use of mechanical ventilation can lead to complications such as ventilator-associated pneumonia, muscle weakness, and decreased cardiac function, so the goal is usually to wean patients off the ventilator as soon as possible.

A syndrome, in medical terms, is a set of symptoms that collectively indicate or characterize a disease, disorder, or underlying pathological process. It's essentially a collection of signs and/or symptoms that frequently occur together and can suggest a particular cause or condition, even though the exact physiological mechanisms might not be fully understood.

For example, Down syndrome is characterized by specific physical features, cognitive delays, and other developmental issues resulting from an extra copy of chromosome 21. Similarly, metabolic syndromes like diabetes mellitus type 2 involve a group of risk factors such as obesity, high blood pressure, high blood sugar, and abnormal cholesterol or triglyceride levels that collectively increase the risk of heart disease, stroke, and diabetes.

It's important to note that a syndrome is not a specific diagnosis; rather, it's a pattern of symptoms that can help guide further diagnostic evaluation and management.

Shyness is not typically defined in medical terms, but it can be considered as a social anxiety or fear of social judgment and negative evaluation. It's characterized by feelings of discomfort, self-consciousness, and apprehension in social situations, which can lead to avoidance behaviors. While shyness itself is not a mental health disorder, extreme shyness can sometimes be a symptom of Social Anxiety Disorder (SAD), which is a recognized medical condition. It's always recommended to seek professional help if shyness is causing significant distress or interfering with daily life.

Multiple System Atrophy (MSA) is a rare, progressive neurodegenerative disorder that affects multiple systems in the body. It is characterized by a combination of symptoms including Parkinsonism (such as stiffness, slowness of movement, and tremors), cerebellar ataxia (lack of muscle coordination), autonomic dysfunction (problems with the autonomic nervous system which controls involuntary actions like heart rate, blood pressure, sweating, and digestion), and pyramidal signs (abnormalities in the corticospinal tracts that control voluntary movements).

The disorder is caused by the degeneration of nerve cells in various parts of the brain and spinal cord, leading to a loss of function in these areas. The exact cause of MSA is unknown, but it is thought to involve a combination of genetic and environmental factors. There is currently no cure for MSA, and treatment is focused on managing symptoms and improving quality of life.

Physical and Rehabilitation Medicine (PRM), also known as Physiatry, is a medical specialty that deals with the prevention, diagnosis, and treatment of patients with disabilities or functional limitations related to musculoskeletal, cardiovascular, pulmonary, neurologic, and other systems. The main goal of this discipline is to restore optimal function, reduce symptoms, and improve the overall quality of life for individuals who have experienced injuries, illnesses, or disabling conditions.

PRM physicians use a variety of techniques, including physical therapy, occupational therapy, speech-language pathology, assistive devices, medications, and various types of injections to manage pain and spasticity. They also perform electrodiagnostic studies to diagnose neuromuscular disorders and provide comprehensive rehabilitation plans tailored to each patient's unique needs and goals.

In addition to direct patient care, PRM specialists often work as part of multidisciplinary teams in hospitals, rehabilitation centers, and outpatient clinics, collaborating with other healthcare professionals such as nurses, therapists, psychologists, and social workers to provide coordinated, holistic care for patients.

An encyclopedia is a comprehensive reference work containing articles on various topics, usually arranged in alphabetical order. In the context of medicine, a medical encyclopedia is a collection of articles that provide information about a wide range of medical topics, including diseases and conditions, treatments, tests, procedures, and anatomy and physiology. Medical encyclopedias may be published in print or electronic formats and are often used as a starting point for researching medical topics. They can provide reliable and accurate information on medical subjects, making them useful resources for healthcare professionals, students, and patients alike. Some well-known examples of medical encyclopedias include the Merck Manual and the Stedman's Medical Dictionary.

Speech Therapy, also known as Speech-Language Pathology, is a medical field that focuses on the assessment, diagnosis, treatment, and prevention of communication and swallowing disorders in children and adults. These disorders may include speech sound production difficulties (articulation disorders or phonological processes disorders), language disorders (expressive and/or receptive language impairments), voice disorders, fluency disorders (stuttering), cognitive-communication disorders, and swallowing difficulties (dysphagia).

Speech therapists, who are also called speech-language pathologists (SLPs), work with clients to improve their communication abilities through various therapeutic techniques and exercises. They may also provide counseling and education to families and caregivers to help them support the client's communication development and management of the disorder.

Speech therapy services can be provided in a variety of settings, including hospitals, clinics, schools, private practices, and long-term care facilities. The specific goals and methods used in speech therapy will depend on the individual needs and abilities of each client.

Occupational therapy (OT) is a healthcare profession that aims to improve the daily living and functional abilities of individuals who have physical, sensory, or cognitive disabilities. OT focuses on helping people participate in the activities of everyday life, such as self-care tasks (e.g., dressing, grooming), productive tasks (e.g., work, school), and leisure activities (e.g., hobbies, sports).

Occupational therapists use a variety of interventions to achieve these goals, including:

1. Customized treatment plans that focus on the individual's specific needs and goals.
2. Adaptive equipment and assistive technology to help individuals perform activities more independently.
3. Education and training for individuals, families, and caregivers on how to use adaptive equipment and techniques.
4. Environmental modifications to make daily activities safer and more accessible.
5. Skill development and practice in areas such as fine motor coordination, cognitive skills, and sensory processing.

Occupational therapy can be provided in a variety of settings, including hospitals, rehabilitation centers, outpatient clinics, schools, and private homes. OT is often recommended for individuals who have experienced a stroke, brain injury, spinal cord injury, or other conditions that affect their ability to perform daily activities.

Speech disorders refer to a group of conditions in which a person has difficulty producing or articulating sounds, words, or sentences in a way that is understandable to others. These disorders can be caused by various factors such as developmental delays, neurological conditions, hearing loss, structural abnormalities, or emotional issues.

Speech disorders may include difficulties with:

* Articulation: the ability to produce sounds correctly and clearly.
* Phonology: the sound system of language, including the rules that govern how sounds are combined and used in words.
* Fluency: the smoothness and flow of speech, including issues such as stuttering or cluttering.
* Voice: the quality, pitch, and volume of the spoken voice.
* Resonance: the way sound is produced and carried through the vocal tract, which can affect the clarity and quality of speech.

Speech disorders can impact a person's ability to communicate effectively, leading to difficulties in social situations, academic performance, and even employment opportunities. Speech-language pathologists are trained to evaluate and treat speech disorders using various evidence-based techniques and interventions.

Shy GM, Drager GA (May 1960). "A neurological syndrome associated with orthostatic hypotension: a clinical-pathologic study". ... "Multiple System Atrophy / Shy Drager Syndrome". Vanderbilt Autonomic Dysfunction Center. Retrieved May 29, 2010. Bloomfield SM ... Schatz IJ (July 1996). "Farewell to the "Shy-Drager syndrome"". Annals of Internal Medicine. 125 (1): 74-75. doi:10.7326/0003- ... These include striatonigral degeneration (SND), olivopontocerebellar atrophy (OPCA), and Shy-Drager syndrome. A table ...
Lloyd Ohlin, 90, American criminologist, complications of Shy-Drager syndrome. Ivan Semedi, 87, Ukrainian Roman Catholic ...
He is reported to have suffered from Shy-Drager syndrome. The Chronicle Journal Staff (July 11, 2009). "Talakoski, Ronald ...
Victor Braun, 65, Canadian baritone, Shy-Drager syndrome, multiple system atrophy. Nadezhda Grigoryevna Grekova, 90, Soviet/ ...
He died in Dallas on 1 September 1993, of Shy-Drager syndrome. "Corrigan, Robert W. (Robert Willoughby), 1927-1993". SNAC. ...
... formerly known as Shy-Drager syndrome. Clinical features that distinguish Parkinson-plus syndromes from idiopathic PD include ... Parkinson-plus syndromes are usually more rapidly progressive and less likely to respond to antiparkinsonian medication than PD ... Parkinson-plus syndromes (PPS) are a group of neurodegenerative diseases featuring the classical features of Parkinson's ... Additional Parkinson-plus syndromes include Pick's disease and olivopontocerebellar atrophy. The latter is characterized by ...
Braun died of Shy-Drager syndrome at the age of 65 in 2001. Braun leaves behind several children - his son Russell Braun is ...
In 2013, his neurologist re-diagnosed his condition as Shy-Drager syndrome (SDS). SDS is a rare, aggressive disease that halts ...
... studies were done on Shy-Drager syndrome. Shy-Drager syndrome is a rare neurodegenerative disease that attacks the autonomic ... Since the main symptom of Shy-Drager syndrome is incontinence it makes it a good candidate to study its effects on Onuf's ... When the sacral sections of the spinal cord were studied in patients with Shy-Drager syndrome, it was revealed that cell death ... "The Onuf's nucleus and the external anal sphincter muscles in amyotrophic lateral sclerosis and Shy-Drager syndrome". Acta ...
Shively died of Shy-Drager syndrome at the age of 84 in Oakland, California. Most notable among his works covering popular ...
London died in New York City on June 12, 1990, of complications from Shy-Drager syndrome. He was 79 years old. He was survived ...
Perrin, who had Shy-Drager syndrome, died at his farmhouse on November 21, 2004, aged 77. A Passport Secretly Green (1961) Dr. ...
Donald Howard Shively, 84, American professor, among the first to promote modern East Asian Studies, Shy-Drager syndrome. ... Charles Alden Black, 86, American businessman, husband of Shirley Temple, myelodysplastic syndrome. "Little" Milton Campbell, ...
In 1992, after Howard was diagnosed with Shy-Drager syndrome, a progressive failure of the autonomic nervous system, he took a ...
Ohlin died at the age of 90 on December 6, 2008 at his home in Santa Barbara, California of Shy-Drager syndrome, a ...
In 1997, during a trip to New York City, Cash was diagnosed with the neurodegenerative disease Shy-Drager syndrome, a form of ... Soon afterwards, his diagnosis was changed to Shy-Drager, and Cash was told he had about 18 months to live. The diagnosis was ...
Shy-Drager syndrome, and various lesions in the brain. Medications that have been associated include Lithium, sulpiride, and a ... Meige syndrome with apraxia of lid opening after the discontinuation of sulpiride treatment. Pharmacopsychiatry. 2002 Jul. 35(4 ... Isolated eyelid-opening apraxia: report of a new levodopa-responsive syndrome. Neurology. 1994 Sep. 44(9):1752-4 Lee KC, Finley ...
... shy-drager syndrome MeSH C10.574.625.800 - striatonigral degeneration MeSH C10.574.781.500 - lambert-eaton myasthenic syndrome ... shy-drager syndrome MeSH C10.228.140.079.612.800 - striatonigral degeneration MeSH C10.228.140.079.737 - neuroleptic malignant ... shy-drager syndrome MeSH C10.228.662.550.800 - striatonigral degeneration MeSH C10.228.662.600 - parkinsonian disorders MeSH ... cri-du-chat syndrome MeSH C10.597.606.643.210 - de lange syndrome MeSH C10.597.606.643.220 - down syndrome MeSH C10.597.606.643 ...
Shy-Drager syndrome) Neuroacanthocytosis Neuronal ceroid lipofuscinosis Olivopontocerebellar atrophy Pantothenate kinase- ... Parkinsonian syndromes are a group of movement disorders characterized by classical motor symptoms such as tremors, ... GeneReviews/NIH/NCBI/UW entry on Perry syndrome GeneReviews/NCBI/NIH/UW entry on X-Linked Dystonia-Parkinsonism (CS1 Spanish- ... Carod-Artal FJ (2003). "[Neurological syndromes linked with the intake of plants and fungi containing a toxic component (I). ...
Shy-Drager syndrome MeSH C14.907.553.120 - brain ischemia MeSH C14.907.553.180 - colitis, ischemic MeSH C14.907.553.241 - ... long QT syndrome MeSH C14.280.067.565.070 - Andersen syndrome MeSH C14.280.067.565.440 - Jervell and Lange-Nielsen syndrome ... Behcet syndrome MeSH C14.907.940.110 - Churg-Strauss syndrome MeSH C14.907.940.560 - mucocutaneous lymph node syndrome MeSH ... CREST syndrome MeSH C14.907.790.100 - anterior spinal artery syndrome MeSH C14.907.790.550 - spinal cord ischemia MeSH C14.907. ...
... syndrome Shy-Drager syndrome Shy-Drager syndrome Sick building syndrome Sick sinus syndrome Silver-Russell syndrome Simpson- ... syndrome Wende-Bauckus syndrome Werner syndrome Wernicke-Korsakoff syndrome West syndrome Westerhof syndrome Wet lung syndrome ... syndrome Shone's syndrome Short anagen syndrome Short bowel syndrome short limb syndrome Short man syndrome Short QT syndrome ... syndrome Radial tunnel syndrome Rage syndrome Raghib syndrome Raine syndrome Ramos-Arroyo syndrome Ramsay Hunt syndrome type 1 ...
... syndrome Shingles Shy-Drager syndrome Sjögren's syndrome Sleep apnea Sleeping sickness Slurred speech Snatiation Sotos syndrome ... 15 Joubert syndrome Karak syndrome Kearns-Sayre syndrome Kinsbourne syndrome Kleine-Levin syndrome Klippel Feil syndrome Krabbe ... Febrile seizures Fisher syndrome Fibromyalgia Foville's syndrome Fragile X syndrome Fragile X-associated tremor/ataxia syndrome ... syndrome Rhythmic movement disorder Romberg syndrome Savant syndrome Saint Vitus dance Sandhoff disease Sanfilippo syndrome ...
Shprintzen syndrome Shwachman syndrome Shwachman-Bodian-Diamond syndrome Shwartzman phenomenon Shy-Drager syndrome Sialadenitis ... Battles syndrome Sommer-Young-Wee-Frye syndrome Sondheimer syndrome Sonoda syndrome Sosby syndrome Sotos syndrome Southwestern ... Fryns syndrome Smith-Fineman-Myers syndrome Smith-Lemli-Opitz syndrome Smith-Martin-Dodd syndrome Smith-Magenis syndrome ... syndrome Say-Barber-Hobbs syndrome Say-Barber-Miller syndrome Say-Carpenter-syndrome Say-Field-Coldwell syndrome Say-Meyer ...
Shy Drager Syndrome, which is known as multiple system atrophy, is a terminal phase of a neurological disorder which occurs ... Shy Drager Syndrome - Symptoms, Prognosis, Causes, Diagnosis, Treatment. What is Shy Drager Syndrome?. Shy Drager Syndrome, ... Shy drager syndrome diagnosis:. In diagnosing the persons with Shy Drager Syndrome, physicians, who are either in the neurology ... The life expectancy with persons having Shy Drager Syndrome falls from the time and day she was diagnosed is from 7 up to 9 ...
The treatment for Shy-Drager syndrome is to facilitate urinary storage with anticholinergic agents coupled with CIC or ... Shy-Drager syndrome is a rare, progressive, degenerative disease affecting the autonomic nervous system with multisystem organ ... Patients with Shy-Drager syndrome should avoid undergoing TURP because the risk of total incontinence is high. ... Hydrocephalus, cerebral palsy, and Shy-Drager syndrome are also central nervous system pathologies that impact voiding function ...
The treatment for Shy-Drager syndrome is to facilitate urinary storage with anticholinergic agents coupled with CIC or ... Shy-Drager syndrome is a rare, progressive, degenerative disease affecting the autonomic nervous system with multisystem organ ... Patients with Shy-Drager syndrome should avoid undergoing TURP because the risk of total incontinence is high. ... Hydrocephalus, cerebral palsy, and Shy-Drager syndrome are also central nervous system pathologies that impact voiding function ...
Shy-Drager syndrome. *Sporadic olivopontocerebellar atrophy. Additional Information & Resources. Genetic Testing Information. * ...
Shy GM, Drager GA (May 1960). "A neurological syndrome associated with orthostatic hypotension: a clinical-pathologic study". ... "Multiple System Atrophy / Shy Drager Syndrome". Vanderbilt Autonomic Dysfunction Center. Retrieved May 29, 2010. Bloomfield SM ... Schatz IJ (July 1996). "Farewell to the "Shy-Drager syndrome"". Annals of Internal Medicine. 125 (1): 74-75. doi:10.7326/0003- ... These include striatonigral degeneration (SND), olivopontocerebellar atrophy (OPCA), and Shy-Drager syndrome. A table ...
The Shy-Drager syndrome with features of parkinsonism and autonomic failure with OH was described in 1960. The term MSA was ... When autonomic failure predominates, MSA was sometimes termed Shy-Drager syndrome (not defined in the present consensus anymore ... The concept of MSA as a unitary diagnosis encompassing several clinical syndromes has a long history. The first cases of MSA ... Neuropharmacologic distinction of neurogenic orthostatic hypotension syndromes. Clin Neuropharmacol. 2006 May-Jun. 29(3):97-105 ...
Lloyd Ohlin, 90, American criminologist, complications of Shy-Drager syndrome. Ivan Semedi, 87, Ukrainian Roman Catholic ...
Also known as Shy-Drager Syndrome.. N. Expand All Collapse All * Neurobehavioral. ...
Also known as Shy-Drager Syndrome.. N. Expand All Collapse All * Neurobehavioral. ...
Shy Drager Syndrome: How to Recognize Signs and Symptoms. Medically reviewed by Angelica Balingit, MD ...
Shy Drager Syndrome: How to Recognize Signs and Symptoms. Medically reviewed by Angelica Balingit, MD ... According to the DSM-5, the broader diagnosis of ASD encompasses conditions such as Aspergers syndrome. Learn more about ...
... and Shy-Drager Syndrome (or multiple system atrophy).. Postural orthostatic tachycardia syndrome describes the feeling of ... and there may be a relationship with chronic fatigue syndrome. ... changes seen in postural orthostatic tachycardia syndrome.. For ...
Multiple sclerosis, multiple system atrophy (e.g., Shy-Drager syndrome), Parkinson disease/parkinsonism, Wernicke ... Postural tachycardia syndrome. Young adults (predominantly female); associated with chronic fatigue syndrome and mitral valve ... Cardiac syncope (long QT syndrome, Brugada syndrome, arrhythmogenic right ventricular dysplasia/cardiomyopathy, structural ... Carotid sinus syndrome/hypersensitivity. Head rotation or pressure on the carotid sinus (e.g., from shaving or tight collar) ...
QT interval and QT dispersion in multiple system atrophy (Shy-Drager syndrome). Clin Auton Res. (1996) 6:67-70. doi: 10.1007/ ... olivopontocerebellar atrophy and Shy-Drager syndrome). J Neurol Sci. (1989) 94:79-100. doi: 10.1016/0022-510X(89)90219-0 ... Baroreflex sensitivity and power spectral analysis in different extrapyramidal syndromes. J Neural Transm (Vienna). (2008) 115: ...
Multiple system atrophy (MSA; MSA-A, formerly Shy-Drager syndrome; MSA-P, striatonigral degeneration; MSA-C, ...
Shy-Drager syndrome. * MSA-P (striatonigral degeneration)*putaminal rim sign. *olivopontocerebellar atrophy (MSA-C) ... Parkinson disease is by far the most common cause of the parkinsonian syndrome, accounting for approximately 80% of cases (the ...
Shy-Drager syndrome. * MSA-P (striatonigral degeneration)*putaminal rim sign. *olivopontocerebellar atrophy (MSA-C) ... neuronal intranuclear hyaline inclusion disease strongly resemble those seen in fragile X-associated tremor/ataxia syndrome ( ...
My dad died from a very unusual and rare disease called Shy Drager syndrome. Its sort of a combination of Lou Gehrigs, MS, ...
MSA includes conditions that were previously known individually as Shy-Drager syndrome, striatonigral degeneration and sporadic ... There is no ideal way to define and distinguish Parkinsons disease from other parkinsonian syndromes. ...
See more studies on Shy-Drager syndrome and.... How is this determined? The order of these related concepts is determined by a ... start str = Shy-Drager syndrome. sql str = Shy-Drager syndrome. start str = Dopaminergic. sql str = Dopaminergic. ...
Shy-Drager syndrome is a multiple-system atrophy disorder mainly characterized by idiopathic orthostatic hypotension but also ... and Shy-Drager syndrome, while peripheral neuropathies leading to hypo- or anhidrosis include diabetes mellitus, Fabry disease ... Hyperthermic syndromes caused by medications include serotonin syndrome, neuroleptic malignant syndrome, anticholinergic ... Guillain-Barre syndrome, and Ross syndrome.. Whether selectively or disproportionally, many peripheral neuropathies affect ...
H � Shy�Drager syndrome Shy�Drager syndrome is a degenerative disease of the autonomic nervous system. It presents with ... Overlap syndromes describe instances in which sufferers have more than one connective tissue disease concurrently. Multiple ... The syndrome is characterized by retinal and intracranial haemangiomas and haemangioblastomas, renal cysts, renal cell ... carpal tunnel syndrome, hypertension, hyperglycaemia and cardiomegaly. Features embrace a number of cutaneous neurofibromas, ...
Shy-Drager syndrome. Gastroparesis Medications, ketoacidosis, gastric or intestinal obstruction. Constipation Medications, ... Three overlapping clinical syndromes have been described: * Acute painful neuropathy, an uncommon but extremely unpleasant ... Diabetic nephropathy represents a distinct clinical syndrome characterized by albuminuria, hypertension, and progressive renal ... nephrotic syndrome, elevated serum creatinine (,2 mg/dL), or diminished GFR (,50 mL per minute). * Instruct patients with ...
... formerly Shy-Drager syndrome), 23% had pure autonomic failure (Bradbury-Eggleston syndrome), 23% had diabetes mellitus, 12% had ... Orthostatic hypotension may be idiopathic (Bradbury-Eggleston syndrome) or may arise as a result of disorders affecting the ... The most common diagnosis was diabetes (27.8%), followed by Parkinsons disease (22.7%), Bradbury-Eggleston syndrome (20.6%), ... losing adrenogenital syndrome. It does not have marketing authorisation in the UK for treating orthostatic hypotension; ...
Shy-Drager Syndrome Preferred Term Term UI T037740. Date01/01/1999. LexicalTag EPO. ThesaurusID ... Shy-Drager Syndrome. Tree Number(s). C10.177.575.550.750. C10.228.140.079.612.700. C10.228.662.550.700. C14.907.514.741. Unique ... Shy-Drager Syndrome Preferred Concept UI. M0019808. Scope Note. A progressive neurodegenerative condition of the central and ... Dysautonomia-Orthostatic Hypotension Syndrome Idiopathic Orthostatic Hypotension, Shy-Drager Type Orthostatic Hypotension, ...
MSA was formerly called Shy-Drager syndrome, olivopontocerebellar atrophy or striatonigral degeneration. MSA shares many ...
In 1997, Cash was diagnosed with the neurodegenerative disease Shy-Drager syndrome, a diagnosis that was later altered to ...
Shy-Drager syndrome. Shy-Drager syndrome is a rare, progressive, and degenerative disease affecting the ANS with multisystem ... Hydrocephalus, cerebral palsy, and Shy-Drager syndrome also are brain lesions. Shy-Drager syndrome is a rare condition that ... The treatment for Shy-Drager syndrome is to facilitate urinary storage with anticholinergic agents coupled with CIC or ... Patients with Shy-Drager syndrome should avoid undergoing TURP because the risk of total incontinence is high. ...
  • MSA includes conditions that were previously known individually as Shy-Drager syndrome, striatonigral degeneration and sporadic olivopontocerebellar atrophy. (parkinson.ca)
  • MSA was formerly called Shy-Drager syndrome, olivopontocerebellar atrophy or striatonigral degeneration. (middlesexhealth.org)
  • It includes 3 disorders previously thought to be distinct: olivopontocerebellar atrophy, striatonigral degeneration, and Shy-Drager syndrome. (msdmanuals.com)
  • It is quite similar to the Parkinson's disease since the persons with this syndrome manifest Parkinsonism like symptoms, which may be described further in this article. (ehealthwall.com)
  • The Shy-Drager syndrome with features of parkinsonism and autonomic failure with OH was described in 1960. (medscape.com)
  • Parkinsonism is a clinical syndrome characterized by tremor , bradykinesia (slowed movements), rigidity , and postural instability . (wikipedia.org)
  • Neuroleptic malignant syndrome or parkinsonism-hyperpyrexia syndrome can develop if their medications are held too long or as a result of serious infection.1 Many drugs used in the perioperative period, such as metoclopramide, butyrophenones , and phenothiazines have anti-dopaminergic activity that can worsen the symptoms of PD. (parkinsonsdaily.com)
  • There is no known cure for this syndrome and the treatments which are prescribing to persons who are diagnosed with this syndrome are medications which will only control the symptoms that the person manifests. (ehealthwall.com)
  • Orthostatic intolerance syndromes refer to symptoms in which the upright position (most often the movement from sitting or lying to an upright position) causes symptomatic arterial hypotension. (camomienoteca.com)
  • The symptoms of akinesia are shown when the patient is affected with Shy drager syndrome, which is a rare medical condition. (healthmd.net)
  • After four or five years of increasing dosages their effect becomes sporadic and unpredictable (the "on-off syndrome") and patients become increasingly helpless and depressed. (digitalnaturopath.com)
  • The main difference from Parkinson's disease from this syndrome is that the damage in the person's body is extensive when a person is diagnosed with this kind of syndrome. (ehealthwall.com)
  • The most common first sign of MSA is the appearance of an "akinetic-rigid syndrome" (i.e. slowness of initiation of movement resembling Parkinson's disease) found in 62% at first presentation. (wikipedia.org)
  • There is no ideal way to define and distinguish Parkinson's disease from other parkinsonian syndromes. (parkinson.ca)
  • Parkinson's syndrome" redirects here. (wikipedia.org)
  • Parkinson disease is by far the most common cause of the parkinsonian syndrome , accounting for approximately 80% of cases (the remainder being due to other neurodegenerative diseases, such as Lewy body dementia ) 1 . (radiopaedia.org)
  • He has so much more that he's accomplished and was truly well known for his country music, but in 1997 Cash was diagnosed with the neurodegenerative disease Shy - Drager syndrome. (fortheloveofnews.com)
  • The concept of MSA as a unitary diagnosis encompassing several clinical syndromes has a long history. (medscape.com)
  • Conventional brain MRI findings of patients with neuronal intranuclear hyaline inclusion disease strongly resemble those seen in fragile X-associated tremor/ataxia syndrome (FXTAS) , including symmetric white matter involvement in combination with hyperintense changes of the middle cerebellar peduncles 4 . (radiopaedia.org)
  • Shy Drager Syndrome, which is known as multiple system atrophy , is a terminal phase of a neurological disorder which occurs rarely. (ehealthwall.com)
  • The exact causative agent or cause why this syndrome occurs is still unknown. (ehealthwall.com)
  • Besides nerve localization in the peripheral nervous system, it occurs in diseases of the presynaptic neuromuscular junction such as botulism and myasthenic syndrome. (medscape.com)
  • MSA is also different from multiple organ dysfunction syndrome, sometimes referred to as multiple organ failure, and from multiple organ system failures, an often-fatal complication of septic shock and other severe illnesses or injuries. (wikipedia.org)
  • Shy Drager Syndrome (SDS) is a movement disorder which is often referred to as a parkinson plus syndrome or Multiple System Atrophy (MSA). (camomienoteca.com)
  • Patients typically live for around 7-10 years after he or she has been diagnosed with multiple system atrophy or Shy-drager syndrome. (naturalayurvedictreatment.com)
  • MSA is distinct from multisystem proteinopathy, a more common muscle-wasting syndrome. (wikipedia.org)
  • My dad died from a very unusual and rare disease called Shy Drager syndrome. (livingontheedge.org)
  • See more studies on Shy-Drager syndrome and. (naturalnews.com)
  • Though caution is still advised, several studies have demonstrated that the risk of serotonin syndrome with these selective MAOI-B drugs is extremely low, even in combination with serotonergic antidepressants. (parkinsonsdaily.com)
  • AIDS-like syndrome: AIDS-like disease (illness) (syndrome) ARC AIDS-related complex Pre-AIDS AIDS-related conditions Prodromal-AIDS 3. (cdc.gov)
  • Moreira RK, Lee H, Stapp R, Ormsby A, Shah V. Immunohistochemical staining of inflammatory cells in liver biopsy specimens of patients with autoimmune hepatitis, primary biliary cirrhosis, and overlap syndromes. (umassmed.edu)
  • That at risk for encountering or experiencing this syndrome falls to the ages in the middle to older persons. (ehealthwall.com)
  • Aside from the age, the male gender is the one of greater risk to experiencing this syndrome. (ehealthwall.com)
  • Progressive Supranuclear Palsy (PSP), also called Stelle-Richardson-Olszewski Syndrome, reflects the combined names of the scientists who defined the disorder in 1964. (davisphinneyfoundation.org)
  • Subsequently, patients with progressive supranuclear palsy develop ophthalmoplegia, pseudobulbar syndrome, emotional and cognitive impairment. (symptomsus.com)
  • LSVT LOUD has also been applied to individuals with sub-types of PD (Shy-Drager syndrome, multi-system atrophy and progressive supranuclear palsy), however the largest dataset is for individuals with Idiopathic Parkinson disease (IPD). (ashleysmallslp.com)
  • Shy Drager Syndrome or now known by its present name, Multiple System Atrophy (MSA), is a rare neurological disorder that affects essential bodily functions such as mobility, speech, vision, and internal body functions such as blood pressure, digestive tract, and urinary tract. (seniorsbenefit.org)
  • That's why in 1998, Shy Drager Syndrome is changed to a more appropriate name which is Multiple System Atrophy or MSA. (seniorsbenefit.org)
  • Multiple system atrophy is also known as shy-drager syndrome. (naturalayurvedictreatment.com)
  • Shy drager's syndrome causes shrinkage or atrophy of portions of your brain that are cerebellum, basal ganglia and brainstem. (naturalayurvedictreatment.com)
  • Patients typically live for around 7-10 years after he or she has been diagnosed with multiple system atrophy or Shy-drager syndrome. (naturalayurvedictreatment.com)
  • The newly described addition to the prion disease canon, Shy-Drager syndrome (SDS) or multiple system atrophy (MSA), was first recognised in the early 1960s and has many features in common with Parkinson's disease. (iflscience.com)
  • The Shy-Drager syndrome is part of a spectrum of multiple systems atrophy which evidence of cerebellar and extrapyramidal involvement is generally present but not evidence of peripheral autonomic degeneration on formal testing (see Table 451-4) and brain stem autonomic nuclei, but not in autonomic ganglia. (forexinfolink.com)
  • his parents and two brothers, Robert E. and Merle L. Creed.The family would appreciate memorials for research on the Shy-Drager Syndrome, in care of Vanderbilt Shy-Drager Research Fund, Vanderbilt University Medical Center, AA-3228 Medical Center North, Nashville, TN 37232. (powelltribune.com)
  • Shy Drager Syndrome was discovered by a neurologist, Dr. Milton Shy from the National Institute of Health and Glen Drager of the College of Medicine wherein they first theorized that orthostatic hypotension is the culprit. (seniorsbenefit.org)
  • However, 'pill-rolling' Parkinson's disease tremor is often not exhibited in these other syndromes. (pharmacology2000.com)
  • Just like other chronic illnesses , Shy Drager Syndrome or MSA is common in older adults who are above 60 and is more common in older men than women. (seniorsbenefit.org)
  • However, because of the common parkinsonian features, the disorders have been collectively named Parkinson-plus syndromes. (medscape.com)
  • Sleep-related breathing disorders are a group of clinical conditions ranging from habitual snoring to obstructive sleep apnea syndrome (OSAS) during the lifespan. (intechopen.com)
  • The Movement Disorders division oversees a specialized clinic for adult and pediatric patients with Tourette syndrome. (vumc.org)
  • The Vanderbilt Center for Tourette Syndrome and Other Tic Disorders provides coordinated, multidisciplinary care for children and adults with tic disorders. (vumc.org)
  • The most common first sign of MSA is the appearance of an "akinetic-rigid syndrome" (i.e. slowness of initiation of movement resembling Parkinson's disease) found in 62% at first presentation. (wikipedia.org)
  • Modern immunocytochemical techniques and genetic findings suggest that Parkinson-plus syndromes can be broadly grouped into 2 types: synucleinopathies and tauopathies. (medscape.com)
  • MSA is distinct from multisystem proteinopathy, a more common muscle-wasting syndrome. (wikipedia.org)
  • Hallucinations and delusions become more disabled and as a powder that must also include neuropathies and spinal cord syndromes can have life threatening ventricular arrhythmia. (easternpropane.com)
  • In the search bar, type in the diagnosis as given by your doctor, or keywords, (eg MIRAGE syndrome or simply MIRAGE). (rare-e-connect.eu)
  • PMID- 5097502 TI - A pericentric inversion, 5 p-q+, and additional complex rearrangements in a case of cri-du-chat syndrome. (nih.gov)
  • Problems can affect either part of the system, as in complex regional pain syndromes , or all of the system. (blogspot.com)
  • Furthermore, and some patients may play a more benign, o en an escape rhythm either rom the backboard as soon as possible, the arterial to arterial blood pressure. (easternpropane.com)