Skin
Skin Diseases
Identification of heparin-binding EGF-like growth factor as a target in intercellular regulation of epidermal basal cell growth by suprabasal retinoic acid receptors. (1/156)
The role of retinoic acid receptors (RARs) in intercellular regulation of cell growth was assessed by targeting a dominant-negative RARalpha mutant (dnRARalpha) to differentiated suprabasal cells of mouse epidermis. dnRARalpha lacks transcriptional activation but not DNA-binding and receptor dimerization functions. Analysis of transgenic mice revealed that dnRARalpha dose-dependently impaired induction of basal cell proliferation and epidermal hyperplasia by all-trans RA (tRA). dnRARalpha formed heterodimers with endogenous retinoid X receptor-alpha (RXRalpha) over RA response elements in competition with remaining endogenous RARgamma-RXRalpha heterodimers, and dose-dependently impaired retinoid-dependent gene transcription. To identify genes regulated by retinoid receptors and involved in cell growth control, we analyzed the retinoid effects on expression of the epidermal growth factor (EGF) receptor, EGF, transforming growth factor-alpha, heparin-binding EGF-like growth factor (HB-EGF) and amphiregulin genes. In normal epidermis, tRA rapidly and selectively induced expression of HB-EGF but not the others. This induction occurred exclusively in suprabasal cells. In transgenic epidermis, dnRARalpha dose-dependently inhibited tRA induction of suprabasal HB-EGF and subsequent basal cell hyperproliferation. Together, our observations suggest that retinoid receptor heterodimers located in differentiated suprabasal cells mediate retinoid induction of HB-EGF, which in turn stimulates basal cell growth via intercellular signaling. These events may underlie retinoid action in epidermal regeneration during wound healing. (+info)Limb and skin abnormalities in mice lacking IKKalpha. (2/156)
The gene encoding inhibitor of kappa B (IkappaB) kinase alpha (IKKalpha; also called IKK1) was disrupted by gene targeting. IKKalpha-deficient mice died perinatally. In IKKalpha-deficient fetuses, limb outgrowth was severely impaired despite unaffected skeletal development. The epidermal cells in IKKalpha-deficient fetuses were highly proliferative with dysregulated epidermal differentiation. In the basal layer, degradation of IkappaB and nuclear localization of nuclear factor kappa B (NF-kappaB) were not observed. Thus, IKKalpha is essential for NF-kappaB activation in the limb and skin during embryogenesis. In contrast, there was no impairment of NF-kappaB activation induced by either interleukin-1 or tumor necrosis factor-alpha in IKKalpha-deficient embryonic fibroblasts and thymocytes, indicating that IKKalpha is not essential for cytokine-induced activation of NF-kappaB. (+info)Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase. (3/156)
The oligomeric IkappaB kinase (IKK) is composed of three polypeptides: IKKalpha and IKKbeta, the catalytic subunits, and IKKgamma, a regulatory subunit. IKKalpha and IKKbeta are similar in structure and thought to have similar function-phosphorylation of the IkappaB inhibitors in response to proinflammatory stimuli. Such phosphorylation leads to degradation of IkappaB and activation of nuclear factor kappaB transcription factors. The physiological function of these protein kinases was explored by analysis of IKKalpha-deficient mice. IKKalpha was not required for activation of IKK and degradation of IkappaB by proinflammatory stimuli. Instead, loss of IKKalpha interfered with multiple morphogenetic events, including limb and skeletal patterning and proliferation and differentiation of epidermal keratinocytes. (+info)IKK1-deficient mice exhibit abnormal development of skin and skeleton. (4/156)
IkappaB kinases (IKKs) IKK1 and IKK2 are two putative IkappaBalpha kinases involved in NF-kappaB activation. To examine the in vivo functions of IKK1, we generated IKK1-deficient mice. The mutant mice are perinatally lethal and exhibit a wide range of developmental defects. Newborn mutant mice have shiny, taut, and sticky skin without whiskers. Histological analysis shows thicker epidermis, which is unable to differentiate. Limbs and tail are wrapped inside the skin and do not extend properly out of the body trunk. Skeleton staining reveals a cleft secondary palate, split sternebra 6, and deformed incisors. NF-kappaB activation mediated by TNFalpha and IL-1 is diminished in IKK1-deficient mouse embryonic fibroblast (MEF) cells. The IKK complex in the absence of IKK1 is capable of phosphorylating IkappaBalpha and IkappaBbeta in vitro. Our results support a role for IKK1 in NF-kappaB activation and uncover its involvement in skin and skeleton development. We conclude further that the two related kinases IKK1 and IKK2 have distinct functions and can not be substituted for each other's functions. (+info)Ectopic expression of the nude gene induces hyperproliferation and defects in differentiation: implications for the self-renewal of cutaneous epithelia. (5/156)
Nude mice are characterized by the absence of visible hair, epidermal defects, and the failure to develop a thymus. This phenotype results from loss-of-function mutations in Whn (Hfh11), a winged-helix transcription factor. In murine epidermis and hair follicles, endogenous whn expression is induced as epithelial cells initiate terminal differentiation. Using the promoter for the differentiation marker involucrin, transgenic mice that ectopically express whn in stratified squamous epithelia, hair follicles, and the transitional epithelium of the urinary tract were generated. Transgenic epidermis and hair follicles displayed impaired terminal differentiation and a subset of hair defects, such as delayed growth, a waved coat, and curly whiskers, correlated with decreased transforming growth factor (TGF)-alpha expression. The exogenous Whn protein also stimulated epithelial cell multiplication. In the epidermis, basal keratinocytes exhibited hyperproliferation, though transgene expression was restricted to suprabasal, postmitotic cells. Hair follicles failed to enter telogen (a resting period) and remained continuously in an abnormal anagen (the growth phase of the hair cycle). Ureter epithelium developed severe hyperplasia, leading to the obstruction of urine outflow and death from hydronephrosis. Though an immune infiltrate was present occasionally in transgenic skin, the infiltrate was not the primary cause of the epithelial hyperproliferation, as the immune reaction was not observed in all affected transgenics, and the transgene induced identical skin and urinary tract abnormalities in immunodeficient Rag1-null mice. Given the effects of the transgene on cell proliferation and TGFalpha expression, the results suggest that Whn modulates growth factor production by differentiating epithelial cells, thereby regulating the balance between proliferative and postmitotic populations in self-renewing epithelia. (+info)Skin and hair follicle integrity is crucially dependent on beta 1 integrin expression on keratinocytes. (6/156)
beta 1 integrins are ubiquitously expressed receptors that mediate cell-cell and cell-extracellular matrix interactions. To analyze the function of beta1 integrin in skin we generated mice with a keratinocyte-restricted deletion of the beta 1 integrin gene using the cre-loxP system. Mutant mice developed severe hair loss due to a reduced proliferation of hair matrix cells and severe hair follicle abnormalities. Eventually, the malformed hair follicles were removed by infiltrating macrophages. The epidermis of the back skin became hyperthickened, the basal keratinocytes showed reduced expression of alpha 6 beta 4 integrin, and the number of hemidesmosomes decreased. Basement membrane components were atypically deposited and, at least in the case of laminin-5, improperly processed, leading to disruption of the basement membrane and blister formation at the dermal-epidermal junction. In contrast, the integrity of the basement membrane surrounding the beta 1-deficient hair follicle was not affected. Finally, the dermis became fibrotic. These results demonstrate an important role of beta 1 integrins in hair follicle morphogenesis, in the processing of basement membrane components, in the maintenance of some, but not all basement membranes, in keratinocyte differentiation and proliferation, and in the formation and/or maintenance of hemidesmosomes. (+info)New insights into the assembly of extracellular microfibrils from the analysis of the fibrillin 1 mutation in the tight skin mouse. (7/156)
The Tight skin (Tsk) mutation is a duplication of the mouse fibrillin 1 (Fbn1) gene that results in a larger (418 kD) than normal (350 kD) protein; Tsk/+ mice display increased connective tissue, bone overgrowth, and lung emphysema. Lung emphysema, bone overgrowth, and vascular complications are the distinctive traits of mice with reduced Fbn1 gene expression and of Marfan syndrome (MFS) patients with heterozygous fibrillin 1 mutations. Although Tsk/+ mice produce equal amounts of the 418- and 350-kD proteins, they exhibit a relatively mild phenotype without the vascular complications that are associated with MFS patients and fibrillin 1-deficient mice. We have used genetic crosses, cell culture assays and Tsk-specific antibodies to reconcile this discrepancy and gain new insights into microfibril assembly. Mice compound heterozygous for the Tsk mutation and hypomorphic Fbn1 alleles displayed both Tsk and MFS traits. Analyses of immunoreactive fibrillin 1 microfibrils using Tsk- and species-specific antibodies revealed that the mutant cell cultures elaborate a less abundant and morphologically different meshwork than control cells. Cocultures of Tsk/Tsk fibroblasts and human WISH cells that do not assemble fibrillin 1 microfibrils, demonstrated that Tsk fibrillin 1 copolymerizes with wild-type fibrillin 1. Additionally, copolymerization of Tsk fibrillin 1 with wild-type fibrillin 1 rescues the abnormal morphology of the Tsk/Tsk aggregates. Therefore, the studies suggest that bone and lung abnormalities of Tsk/+ mice are due to copolymerization of mutant and wild-type molecules into functionally deficient microfibrils. However, vascular complications are not present in these animals because the level of functional microfibrils does not drop below the critical threshold. Indirect in vitro evidence suggests that a potential mechanism for the dominant negative effects of incorporating Tsk fibrillin 1 into microfibrils is increased proteolytic susceptibility conferred by the duplicated Tsk region. (+info)Magnetic resonance imaging detection of occult skin and subcutaneous abnormalities in juvenile dermatomyositis. Implications for diagnosis and therapy. (8/156)
OBJECTIVE: To assess the utility of magnetic resonance imaging (MRI) of skin, subcutaneous tissue, and fascia in evaluating disease activity in juvenile dermatomyositis (DM). METHODS: Short tau inversion recovery (STIR) MRI of the proximal thighs and buttocks, cutaneous assessment, and other measures of disease activity were prospectively obtained in 26 children meeting criteria for probable or definite juvenile DM. Also undergoing STIR MRI assessment were 8 subjects who were being evaluated for muscle disorders and who were not diagnosed as having juvenile DM. RESULTS: Skin, subcutaneous, or fascial edema of the thighs and buttocks were seen on STIR MRI in up to 85% of juvenile DM patients at baseline evaluation compared with no more than 38% of the comparison group without juvenile DM. In juvenile DM, STIR MRI skin and subcutaneous edema scores correlated (r(s) = 0.51, P = 0.008), as did fascial and muscle edema scores (r(s) = 0.58, P = 0.002). Skin global disease activity scores correlated with MRI skin edema scores (r(s) = 0.41, P = 0.04), and serum aldolase levels correlated with both MRI skin and subcutaneous edema scores (r = 0.44 and 0.40, P = 0.03 and 0.05 respectively). The extent and severity of STIR MRI changes in the skin, subcutaneous tissue, and fascia were not predicted by most other measures of juvenile DM disease activity. Five juvenile DM patients with thigh MRI subcutaneous edema developed clinically apparent calcinosis at the same location within 9 months. CONCLUSION: Edema or inflammation in the skin, subcutaneous tissue, and fascia, found on STIR MRI, is common in juvenile DM patients and is often undetected by standard assessments. These MRI changes can precede the development of calcinosis. STIR MRI may be a useful adjunct for assessing disease activity and guiding the treatment of juvenile DM. (+info)Skin abnormalities refer to any changes in the skin that deviate from its normal structure, function, or color. These can manifest as various conditions such as lesions, growths, discolorations, or textural alterations. Examples include moles, freckles, birthmarks, rashes, hives, acne, eczema, psoriasis, rosacea, skin cancer, and many others. Some skin abnormalities may be harmless and require no treatment, while others might indicate an underlying medical condition that requires further evaluation and management.
Hair diseases is a broad term that refers to various medical conditions affecting the hair shaft, follicle, or scalp. These conditions can be categorized into several types, including:
1. Hair shaft abnormalities: These are conditions that affect the structure and growth of the hair shaft. Examples include trichorrhexis nodosa, where the hair becomes weak and breaks easily, and pili torti, where the hair shaft is twisted and appears sparse and fragile.
2. Hair follicle disorders: These are conditions that affect the hair follicles, leading to hair loss or abnormal growth patterns. Examples include alopecia areata, an autoimmune disorder that causes patchy hair loss, and androgenetic alopecia, a genetic condition that leads to pattern baldness in both men and women.
3. Scalp disorders: These are conditions that affect the scalp, leading to symptoms such as itching, redness, scaling, or pain. Examples include seborrheic dermatitis, psoriasis, and tinea capitis (ringworm of the scalp).
4. Hair cycle abnormalities: These are conditions that affect the normal growth cycle of the hair, leading to excessive shedding or thinning. Examples include telogen effluvium, where a large number of hairs enter the resting phase and fall out, and anagen effluvium, which is typically caused by chemotherapy or radiation therapy.
5. Infectious diseases: Hair follicles can become infected with various bacteria, viruses, or fungi, leading to conditions such as folliculitis, furunculosis, and kerion.
6. Genetic disorders: Some genetic disorders can affect the hair, such as Menkes syndrome, which is a rare inherited disorder that affects copper metabolism and leads to kinky, sparse, and brittle hair.
Proper diagnosis and treatment of hair diseases require consultation with a healthcare professional, often a dermatologist or a trichologist who specializes in hair and scalp disorders.
In medical terms, the skin is the largest organ of the human body. It consists of two main layers: the epidermis (outer layer) and dermis (inner layer), as well as accessory structures like hair follicles, sweat glands, and oil glands. The skin plays a crucial role in protecting us from external factors such as bacteria, viruses, and environmental hazards, while also regulating body temperature and enabling the sense of touch.
Skin diseases, also known as dermatological conditions, refer to any medical condition that affects the skin, which is the largest organ of the human body. These diseases can affect the skin's function, appearance, or overall health. They can be caused by various factors, including genetics, infections, allergies, environmental factors, and aging.
Skin diseases can present in many different forms, such as rashes, blisters, sores, discolorations, growths, or changes in texture. Some common examples of skin diseases include acne, eczema, psoriasis, dermatitis, fungal infections, viral infections, bacterial infections, and skin cancer.
The symptoms and severity of skin diseases can vary widely depending on the specific condition and individual factors. Some skin diseases are mild and can be treated with over-the-counter medications or topical creams, while others may require more intensive treatments such as prescription medications, light therapy, or even surgery.
It is important to seek medical attention if you experience any unusual or persistent changes in your skin, as some skin diseases can be serious or indicative of other underlying health conditions. A dermatologist is a medical doctor who specializes in the diagnosis and treatment of skin diseases.
Skin aging, also known as cutaneous aging, is a complex and multifactorial process characterized by various visible changes in the skin's appearance and function. It can be divided into two main types: intrinsic (chronological or natural) aging and extrinsic (environmental) aging.
Intrinsic aging is a genetically determined and time-dependent process that results from internal factors such as cellular metabolism, hormonal changes, and genetic predisposition. The primary features of intrinsic aging include gradual thinning of the epidermis and dermis, decreased collagen and elastin production, reduced skin cell turnover, and impaired wound healing. Clinically, these changes present as fine wrinkles, dryness, loss of elasticity, and increased fragility of the skin.
Extrinsic aging, on the other hand, is caused by external factors such as ultraviolet (UV) radiation, pollution, smoking, alcohol consumption, and poor nutrition. Exposure to these environmental elements leads to oxidative stress, inflammation, and DNA damage, which accelerate the aging process. The main features of extrinsic aging are coarse wrinkles, pigmentary changes (e.g., age spots, melasma), irregular texture, skin laxity, and increased risk of developing skin cancers.
It is important to note that intrinsic and extrinsic aging processes often interact and contribute to the overall appearance of aged skin. A comprehensive approach to skincare should address both types of aging to maintain healthy and youthful-looking skin.
List of dental abnormalities associated with cutaneous conditions
Thermography
List of skin conditions
Smith-Fineman-Myers syndrome
Griscelli syndrome type 2
Taxi dance hall
Lipomeningomyelocele
Diglyceride acyltransferase
Fountain syndrome
Filippi syndrome
Cat skin disorders
Stiff skin syndrome
Abetalipoproteinemia
Griscelli syndrome
Persian cat
Bart syndrome
SKIV2L
Benign fasciculation syndrome
LIG4 syndrome
Severe achondroplasia with developmental delay and acanthosis nigricans
Acrodysostosis
Collagen, type VII, alpha 1
Kallmann syndrome
CHIME syndrome
Dog skin disorders
2023 Shama quarry explosion
Ethylin Wang Jabs
Lykoi
Neu-Laxova syndrome
Muehrcke's nails
Metal fume fever
Persistent thyroglossal duct
Vascular Abnormalities ( Angiomas, Port Wine Stains ) In Alsager
Multi-task weak supervision enables anatomically-resolved abnormality detection in whole-body FDG-PET/CT | Nature Communications
Walking abnormalities: MedlinePlus Medical Encyclopedia
EEG in Brain Tumors: Overview, Background, Types of EEG Abnormalities Associated With Brain Tumors
The aged epidermal permeability barrier: basis for functional abnormalities
Treatment for Skin Abnormalities | EveresT
Skin Abnormalities Affecting the Penis - Men's Health Issues - MSD Manual Consumer Version
Sperm Abnormalities - Gluten Free Works: TREATMENT GUIDE
Azithromycin for Injection
Vascular proliferations and abnormalities of blood vessels | DermNet
Branchial Cleft Abnormalities in Children | University Hospitals
List of dental abnormalities associated with cutaneous conditions - Wikipedia
Cardiovascular disease - Abnormalities, Heart Chambers, Risk Factors | Britannica
A Case of Perineal Hemangioma, External Genitalia Malformations, Lipomyelomeningocele, Vesicorenal Abnormalities, Imperforate...
Radon Toxicity: Initial Check | Environmental Medicine | ATSDR
Salivary Abnormalities in Dentistry: Overview, Salivary Gland Anatomy, Salivation and Age
Tetrachloroethylene (PERC) | Medical Management Guidelines | Toxic Substance Portal | ATSDR
Normal Abnormalities in Dogs: Typical Changes Caused by Age or Stress
Cutaneous features of myotonic dystrophy types 1 and 2: Implication of premature aging and vitamin D homeostasis
Head and Neck Surgery | Baylor Medicine
Integrative Medicine: Search About Herbs | Memorial Sloan Kettering Cancer Center
Journal Summary: Vitiligo
What Is Coeliac Disease? Coeliac Awareness Week: All you need to know | HELLO!
DailyMed - FUZEON- enfuvirtide kit
Hypothyroidism in Dogs: Symptoms, Causes and Treatment - Dogster
Dr. Lisa Thebner, MD - Pediatrics Specialist in New York, NY | Healthgrades
Oral and Topical Centella asiatica in Type 2 Diabetes Mellitus Patients with Dry Skin: A Three-Arm Prospective Randomized...
Erythroderma
Skeletal1
- Researchers have determined that loss of a particular gene on chromosome 2, called HDAC4 , is likely to account for many of the syndrome's characteristic signs (such as intellectual disability and skeletal abnormalities). (medlineplus.gov)
Chromosomal abnormalities3
- Chromosomal abnormalities typically occur due to a problem with cell division. (medicinenet.com)
- Between 9 and 36 percent of patients with mental retardation have chromosomal abnormalities. (aafp.org)
- In one study, four out of 10 patients with mental retardation attributed to chromosomal abnormalities had no dysmorphologic features, emphasizing the need for cytogenic testing. (aafp.org)
Infection13
- Some dogs bite or scratch at these skin growths resulting in bleeding or infection , and the need for removal. (pethealthnetwork.com)
- or (4) had a history of Koebnerization, a history of keloid or hypertrophic scar formation, allergy to anesthesia , bleeding issues, active infection, or skin cancer or were pregnant or lactating. (medscape.com)
- 3 ] found that 74% of T2DM patients had one or more skin problems, with the highest amount being dry skin (47%), followed by infection (10%), diabetic foot (5%), hair loss, and diabetic dermopathy (4%), respectively. (hindawi.com)
- Dry skin treated properly in early stages can lower diabetes patients' morbidities and prevent complications, which includes infection, ulcer, and gangrene, which could result in amputation [ 4 ]. (hindawi.com)
- The pericarp of this fruit or its fruit rind is used as a traditional medicine in treating various ailments such as trauma, skin infection, abdominal pain, dysentery, and wounds [ 3 ]. (hindawi.com)
- Damage to the skin around your nails could cause infection, too. (healthline.com)
- What Is a Yeast Infection (Skin Rash)? (emedicinehealth.com)
- Candidiasis is by far the most common type of yeast infection in human skin. (emedicinehealth.com)
- It is caused by candidal infection that is allowed to penetrate the skin due to moisture. (emedicinehealth.com)
- Candida can also affect the digestive system and may be associated with ulcers and inflammatory bowel disease ( IBD ), but Candida colonization in the digestive tract is not usually associated with a yeast infection skin rash. (emedicinehealth.com)
- Ringworm is another type of fungal infection caused by a type of fungus called a dermatophyte and can result in athlete's foot, jock itch , scalp infections, and infections of the nails and in skin folds. (emedicinehealth.com)
- How Do You Get a Yeast Infection Skin Rash? (emedicinehealth.com)
- People with diabetes should regularly examine their feet for any skin abnormalities such as ulcers or signs of infection. (who.int)
Systemic3
- Significant amounts of deoxygenated blood in the systemic circulation impart a blue-gray cast to the skin (called cyanosis). (britannica.com)
- Thus, systemic toxicity is unlikely unless liquid on the skin is prevented from evaporating by heavy clothing or other impermeable covering. (cdc.gov)
- Eyelid disorders may be associated with facial and orbital abnormalities, specific breeds, and adjunct skin diseases, as well as with many systemic diseases. (merckvetmanual.com)
Salivary glands2
- Significant abnormality or disease of the salivary glands, such as that associated with Sjögren syndrome or neoplasm, necessitates additional evaluation by an otolaryngologist or an otolaryngologist/head and neck surgeon for comprehensive treatment of the gland pathology itself. (medscape.com)
- Baylor ENT (Otolaryngology) has nationally and internationally recognized surgeons who specialize in diagnosing, treating and rehabilitating cancers and tumors of the head and neck region, including those of the thyroid, skin, salivary glands, ears, sinuses, mouth, throat and voice box. (bcm.edu)
Lesions4
- Skin lesions associated with Rosai-Dorfman disease are usually yellow or purple. (rarediseases.org)
- Skin lesions may occur anywhere on the body, but most often affect the head and neck. (rarediseases.org)
- Porphyrias are divided into two types according to the predominant symptoms: (1) the neurovisceral or acute porphyrias, with abdominal pain, neuropathy, autonomic instability, and psychosis, and (2) the cutaneous porphyrias, with symptoms of photosensitive lesions on the skin. (medscape.com)
- Chronic mucocutaneous candidiasis is a condition that results from a genetic defect that leaves those who have it with thick, horny skin lesions and with nail abnormalities. (emedicinehealth.com)
Moles1
- Common skin abnormalities include moles, warts, and skin tags. (everestmenshealth.com)
Symptoms6
- What are the symptoms of a branchial cleft abnormality in a child? (uhhospitals.org)
- The symptoms of a branchial cleft abnormality can seem like other health conditions. (uhhospitals.org)
- In some cases, affected individual may experience nonspecific symptoms that are common to many different conditions including fever, paleness of the skin (pallor), unintended weight loss, a general feeling of ill health (malaise) and a chronically runny nose (rhinitis). (rarediseases.org)
- The cause may be a dysfunctional skin barrier, and food sensitivities can also trigger symptoms. (medicalnewstoday.com)
- People should avoid scratching, as this can lead to very inflamed areas of skin that may bleed and worsen eczema symptoms. (medicalnewstoday.com)
- Know what the symptoms of exposure are and learn how to treat exposed skin . (cdc.gov)
Granular2
- Leveraging recent advancements in natural language processing, we describe a weak supervision framework that extracts imperfect, yet highly granular, regional abnormality labels from free-text radiology reports. (nature.com)
- Our findings indicate a strong association between ultrastructural abnormalities in the granular layer of epidermis and ichthyin mutations. (bmj.com)
Disorders4
- Some are bodywide skin disorders that affect the penis as well as other parts of the skin. (msdmanuals.com)
- Autosomal recessive congenital ichthyosis (ARCI) is a heterogeneous group of skin disorders. (bmj.com)
- It is frequently associated with autoimmune disorders, particularly with thyroid abnormalities. (medscape.com)
- Uncontrolled diabetes mellitus (DM) is related to skin disorders, particularly dry skin. (hindawi.com)
Recurrent1
- Cases of acute recurrent conjunctivitis and rhinitis were found along with skin pruritus, mainly on exposure to barley dust. (cdc.gov)
Cysts1
- Non-cancerous breast abnormalities include benign masses like fibroadenomas and cysts as well as infections. (who.int)
Chronic4
- Seborrheic Dermatitis Seborrheic dermatitis is chronic inflammation that causes yellow, greasy scales and dandruff to form on areas of the skin that have a high number of oil glands such as the scalp and face, along. (msdmanuals.com)
- occurs when long-term (chronic) inflammation causes the skin near the tip of the penis to harden and turn white. (msdmanuals.com)
- Pathogenesis of dry skin in type 2 diabetes mellitus (T2DM) rises from the chronic hyperglycemia causing an increase in advanced glycation end-products (AGEs), proinflammatory cytokines, and oxidative stress. (hindawi.com)
- Uncontrolled DM is highly correlated with various chronic complications, and amongst them is skin complication. (hindawi.com)
Seizures1
- Other features of 2q37 deletion syndrome can include seizures and an inflammatory skin disorder called eczema. (medlineplus.gov)
Malformations1
- A Case of Perineal Hemangioma, External Genitalia Malformations, Lipomyelomeningocele, Vesicorenal Abnormalities, Imperforate Anus, and Skin Tag (PELVIS) Syndrome with Extensive Perineal Infantile Hemangioma. (bvsalud.org)
Rash2
- A reddish rash-like inflammation of the skin (erythema), small solid elevations on the skin (papules), or knots visible under the skin (nodules) may be present. (rarediseases.org)
- Candidal body rash can result from excess sweating , antibiotic use, or lack of movement leading to skin occlusion (for example, when a medication is applied to the skin and covered). (emedicinehealth.com)
Cutaneous2
- cardio-), facial features (facio-), and the skin and hair (cutaneous). (medlineplus.gov)
- Skin changes are the hallmark of the cutaneous porphyrias. (medscape.com)
Nevi1
- It revealed quantitative and qualitative abnormalities of nevi and typical signs of premature aging in both DM1 and DM2 patients, with a significantly higher frequency of dysplastic nevi, alopecia, xerosis and seborrheic dermatitis. (nih.gov)
Liver1
- I liken such abnormalities to the brown "liver spots" many people develop on their skin in response to sun exposure and aging. (pethealthnetwork.com)
Bone1
- Instead a specific area of the body such as the skin, a solitary bone, or the central nervous system may be affected. (rarediseases.org)
Benign1
- These benign fatty tumors develop under the skin in mature dogs. (pethealthnetwork.com)
Congenital1
- Small defects are among the most common congenital cardiovascular abnormalities and may be less life-threatening, since many such defects close spontaneously. (britannica.com)
Veterinarian2
- Your veterinarian will have various tricks up her sleeve to determine whether such changes represent "normal abnormalities" or are indicators of underlying disease . (pethealthnetwork.com)
- While you are doing your "watchful waiting" count your blessings because, of all the abnormalities you and your veterinarian can find, a "normal abnormality" is the very best kind! (pethealthnetwork.com)
Facial2
- Our results in skin rejuvenation, facial tightening and body shaping, anti-ageing and removal of skin problems are truly. (consultingroom.com)
- Multi award winning clinic of advanced facial skincare treatments & medical aesthetics with an holistic approach for healthy, radiant skin. (consultingroom.com)
Detection4
- The representation also contributes to more accurate mortality prediction from imaging data, suggesting the potential utility of our framework beyond abnormality detection and location estimation. (nature.com)
- This task, which we call anatomically-resolved abnormality detection, is clinically important in FDG-PET/CT studies. (nature.com)
- However, manually labeling a data set for anatomically-resolved abnormality detection is particularly painstaking because it requires either performing pixel-level annotations or sorting abnormalities into a hierarchy of anatomical regions 10 . (nature.com)
- Detection of such abnormalities may signal a need for additional follow-up (e.g., electroencephalography, neuroimaging, genetic testing, referral). (aafp.org)
Tumors1
- It has been established by recent studies that pomegranate derived products abrogate chemically induced tumors of lung, skin, breast and colon and it also abates the metastasis of xenografted lung and prostrate tumors in rodents 13 . (nature.com)
Significant1
- A "normal abnormality" is the term I use to describe something that is worthy of note within my patient's medical record, yet is an anticipated abnormality (given the animal's age , breed , or circumstances) that is highly unlikely to ever become a significant health issue. (pethealthnetwork.com)
Neck2
- A branchial cleft abnormality is a cluster of abnormally formed tissue in the neck. (uhhospitals.org)
- Branchial cleft abnormalities are often found in front of the large muscles on either side of the neck. (uhhospitals.org)
Diseases1
- 2006). Andrews' Diseases of the Skin: Clinical Dermatology. (wikipedia.org)
Abnormal2
- Various cytokine/growth factor signaling pathways are abnormal in aged skin, particularly in the interleukin-1 family. (nih.gov)
- Both complex regional pain syndrome (CRPS) I and II have a hallmark of allodynia, severe hyperalgesia, edema , skin changes, and abnormal alterations in sudomotor and vasomotor function. (medicinenet.com)
Inflammation of the skin1
- There are different types of dermatitis, which means inflammation of the skin. (medicalnewstoday.com)
Birth2
- A branchial cleft abnormality is a birth defect. (uhhospitals.org)
- A 2-month-old girl presented with infantile hemangioma on her perineum and genitalia with imperforate anus , rectovaginal fistula and perineal skin tag at birth . (bvsalud.org)
Epidermal1
- The study showed that CML was detected in the skin epidermal layer [ 5 ]. (hindawi.com)
Specific2
Infections3
- Candidal infections commonly occur in warm, moist body areas, such as the underarms, in the groin, under the breasts, between the legs, and under the folds of the skin of the abdomen of people who are obese . (emedicinehealth.com)
- Candidal infections commonly occur in warm, moist body areas, such as the underarms or where skin folds over itself like breast /chest skin. (emedicinehealth.com)
- Adults can also have yeast infections around dentures , in the folds under the breast and lower abdomen, in the nail beds, and beneath other skin folds. (emedicinehealth.com)
Chromosome4
- The genetic abnormality can range from minuscule to major -- from a discrete mutation in a single base in the DNA of a single gene to a gross chromosomal abnormality involving the addition or subtraction of an entire chromosome or set of chromosomes. (medicinenet.com)
- Because chromosomes are the carriers of the genetic material, abnormalities in chromosome number or structure can result in disease. (medicinenet.com)
- Fluorescence in situ hybridization (FISH) techniques can examine the subtelomeric regions of each chromosome to look for abnormalities that cause mental retardation. (aafp.org)
- In children with mental retardation and normal results on routine chromosome analysis, the FISH technique detects subtelomeric abnormalities in 7.4 percent. (aafp.org)
Redness2
- A stage that may last up to three months, characterized by a constant severe burning or aching pain and increased sensitivity to touch, fluctuations in skin temperature between hot and cold followed by swelling and joint stiffness along with increased warmth and redness in the affected limb. (medicinenet.com)
- Skin softening and redness occur. (emedicinehealth.com)
Serum1
- DM1 and DM2 patients display a high frequency of skin abnormalities, the most common of which correlate with genotype severity and serum vitamin D levels. (nih.gov)
Dogs2
- Here are some examples of commonly encountered "normal abnormalities" in dogs . (pethealthnetwork.com)
- These small, warty appearing skin growths commonly develop in older dogs. (pethealthnetwork.com)
Trauma1
- For example, gait abnormalities from trauma to part of the leg will improve as the leg heals. (medlineplus.gov)
Growths1
- They appear as small, usually skin-colored growths shaped like domes or hairs on the shaft of the penis. (msdmanuals.com)
Erythema1
- The most common adverse events were erythema and skin discomfort such as pruritus, burning sensation, and pain, which occurred only in patients who received phototherapy and laser therapy. (medscape.com)
Epidermis1
- Aged epidermis develops an abnormality in permeability barrier homeostasis, which is accentuated further in photoaged skin. (nih.gov)
Problems2
- Walking abnormalities can be caused by many different types of problems. (medlineplus.gov)
- Although skin problems are often found in T2DM patients, the awareness and choice of treatment are commonly lacking. (hindawi.com)
Conditions1
- Many conditions of or affecting the human integumentary system have associated abnormalities of the teeth. (wikipedia.org)
Scans2
- Using these generated labels, we then train an attention-based, multi-task CNN architecture to detect and estimate the location of abnormalities in whole-body scans. (nature.com)
- CT scans help to find the exact location of the abnormality and how large it is. (uhhospitals.org)
Irritation5
- Dermal exposure to the liquid can cause burns and irritation, but absorption across intact skin is slow. (cdc.gov)
- Direct contact with the liquid can cause skin and eye irritation and burns. (cdc.gov)
- Repellents can cause eye irritation and skin reactions. (epnet.com)
- Acute dermal and eye irritation tests in New Zealand white rabbits indicate that the test item is nonirritant to the skin and eyes. (hindawi.com)
- Intertrigo is an irritation of the folds of the skin. (emedicinehealth.com)
Examination5
- The medical providers at EveresT Men's Health will complete a localized skin examination and may take a small sample of tissue to biopsy in order to rule out skin cancer. (everestmenshealth.com)
- Schedule a skin examination with EveresT Men's Health today! (everestmenshealth.com)
- Skin examination was performed in 60 DM1, 15 DM2, and 103 control, unselected patients by means of dermoscopy. (nih.gov)
- Skin examination is highly informative in these patients and reveals features suggestive of premature aging and impaired vitamin D homeostasis. (nih.gov)
- The neurologic examination (i.e., physical examination focused on detecting neurologic abnormalities) is critical in the evaluation of the child with developmental delays or mental retardation. (aafp.org)
Occur anywhere1
- Skin cancer can occur anywhere on the penis, but it most commonly occurs at the glans penis (the cone-shaped end of the penis), especially. (msdmanuals.com)
Disease4
- What Are Sperm Abnormalities In Celiac Disease and/or Gluten Sensitivity? (glutenfreeworks.com)
- Skin and nail findings could indicate a dermatological problem or disease somewhere else in the body. (webmd.com)
- Abnormalities in an individual's genetic makeup cause genetic disease. (medicinenet.com)
- A genetic disease is any disease caused by an abnormality in the genetic makeup of an individual. (medicinenet.com)
Complications2
- What are possible complications of a branchial cleft abnormality in a child? (uhhospitals.org)
- The primary outcomes assessed were degree of ear anomaly correction and incidence of skin complications. (stanford.edu)
Muscles1
- It can last 3 to 12 months, characterized by a more constant swelling, increased stiffness , brittle and cracked nails, weakening of muscles, the disappearance of skin wrinkles , increased sensitivity to touch, and a lower-than-normal skin temperature. (medicinenet.com)
Small2
- and a skin condition called keratosis pilaris, which causes small bumps to form on the arms, legs, and face. (medlineplus.gov)
- This small sliver of skin at the base of your nail protects the new nail from germs as it grows through your skin. (healthline.com)
Organ1
- The skin is the largest organ of the body, so it only makes sense that you may need to address skin issues occasionally. (everestmenshealth.com)
Anomaly1
- If you have noticed a new or changing skin anomaly, it's a good idea to have it examined. (everestmenshealth.com)
Heart2
- Abnormalities of the heart chambers may be serious and even life-threatening. (britannica.com)
- possibly it's because the merle mutation affects melanocytes, the cells that produce melanin pigment, and melanocytes are found not only in the skin but in the eye and inner ear, as well as the bones and heart. (akc.org)
Cancers1
- Penile Cancer Cancers of the penis are usually types of skin cancers. (msdmanuals.com)
Muscle weakness1
- Similar to the other forms of myositis, JM is characterized by muscle weakness and skin rashes. (healthline.com)