Keratoacanthoma
A benign, non-neoplastic, usually self-limiting epithelial lesion closely resembling squamous cell carcinoma clinically and histopathologically. It occurs in solitary, multiple, and eruptive forms. The solitary and multiple forms occur on sunlight exposed areas and are identical histologically; they affect primarily white males. The eruptive form usually involves both sexes and appears as a generalized papular eruption.
Skin
Skin Diseases
Skin Aging
Pancreatic Neoplasms
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
Neoplasms
Dictionaries, Medical
A medical dictionary is a specialized reference book containing terms, definitions, and explanations related to medical science, healthcare practices, and associated disciplines, used by healthcare professionals, students, researchers, and patients to enhance understanding of medical concepts and terminology.
Malignant Atrophic Papulosis
Variously described as a vasculopathy, endovasculitis, or occlusive arteriopathy, this condition occurs in a benign cutaneous form and a lethal multiorgan systemic variant. It is characterized by a narrowing and occlusion of the lumen of small to medium-sized blood vessels, leading to ischemia and infarction in the involved organ systems. The etiology and pathophysiology are unknown.
Activation of telomerase and its association with G1-phase of the cell cycle during UVB-induced skin tumorigenesis in SKH-1 hairless mouse. (1/10127)
Telomerase is a ribonucleoprotein enzyme that adds hexanucleotide repeats TTAGGG to the ends of chromosomes. Telomerase activation is known to play a crucial role in cell-immortalization and carcinogenesis. Telomerase is shown to have a correlation with cell cycle progression, which is controlled by the regulation of cyclins, cyclin dependent kinases (cdks) and cyclin dependent kinase inhibitors (cdkis). Abnormal expression of these regulatory molecules may cause alterations in cell cycle with uncontrolled cell growth, a universal feature of neoplasia. Skin cancer is the most prevalent form of cancer in humans and the solar UV radiation is its major cause. Here, we investigated modulation in telomerase activity and protein expression of cell cycle regulatory molecules during the development of UVB-induced tumors in SKH-1 hairless mice. The mice were exposed to 180 mjoules/cm2 UVB radiation, thrice weekly for 24 weeks. The animals were sacrificed at 4 week intervals and the studies were performed in epidermis. Telomerase activity was barely detectable in the epidermis of non-irradiated mouse. UVB exposure resulted in a progressive increase in telomerase activity starting from the 4th week of exposure. The increased telomerase activity either persisted or further increased with the increased exposure. In papillomas and carcinomas the enzyme activity was comparable and was 45-fold higher than in the epidermis of control mice. Western blot analysis showed an upregulation in the protein expression of cyclin D1 and cyclin E and their regulatory subunits cdk4 and cdk2 during the course of UVB exposure and in papillomas and carcinomas. The protein expression of cdk6 and ckis viz. p16/Ink4A, p21/Waf1 and p27/Kip1 did not show any significant change in UVB exposed skin, but significant upregulation was observed both in papillomas and carcinomas. The results suggest that telomerase activation may be involved in UVB-induced tumorigenesis in mouse skin and that increased telomerase activity may be associated with G1 phase of the cell cycle. (+info)L-[1-11C]-tyrosine PET to evaluate response to hyperthermic isolated limb perfusion for locally advanced soft-tissue sarcoma and skin cancer. (2/10127)
PET with L-[1-11C]-tyrosine (TYR) was investigated in patients undergoing hyperthermic isolated limb perfusion (HILP) with recombinant tumor necrosis factor alpha (rTNF-alpha) and melphalan for locally advanced soft-tissue sarcoma and skin cancer of the lower limb. METHODS: Seventeen patients (5 women, 12 men; age range 24-75 y; mean age 52 y) were studied. TYR PET studies were performed before HILP and 2 and 8 wk afterwards. The protein synthesis rates (PSRs) in nanomoles per milliliter per minute were calculated. After final PET studies, tumors were resected and pathologically examined. Patients with pathologically complete responses (pCR) showed no viable tumors after treatment. Those with pathologically partial responses (pPR) showed various amounts of viable tumors in the resected tumor specimens. RESULTS: Six patients (35%) showed a pCR and 11 patients (65%) showed a pPR. All tumors were depicted as hot spots on PET studies before HILP. The PSR in the pCR group at 2 and 8 wk after perfusion had decreased significantly (P < 0.05) in comparison to the PSR before HILP. A significant difference was found in PSR between the pCR and pPR groups at 2 and at 8 wk (P < 0.05). Median PSR in nonviable tumor tissue was 0.62 and ranged from 0.22 to 0.91. With a threshold PSR of 0.91, sensitivity and specificity of TYR PET were 82% and 100%, respectively. The predictive value of a PSR > 0.91 for having viable tumor after HILP was 100%, whereas the predictive value of a PSR < or = 0.91 for having nonviable tumor tissue after HILP was 75%. The 2 patients in the pPR groups with a PSR < 0.91 showed microscopic islets of tumor cells surrounded by extensive necrosis on pathological examination. CONCLUSION: Based on the calculated PSR after HILP, TYR PET gave a good indication of the pathological outcome. Inflammatory tissue after treatment did not interfere with viable tumor on the images, suggesting that it may be worthwhile to pursue TYR PET in other therapy evaluation settings. (+info)Frequent nuclear/cytoplasmic localization of beta-catenin without exon 3 mutations in malignant melanoma. (3/10127)
Beta-Catenin has a critical role in E-cadherin-mediated cell-cell adhesion, and it also functions as a downstream signaling molecule in the wnt pathway. Mutations in the putative glycogen synthase kinase 3beta phosphorylation sites near the beta-catenin amino terminus have been found in some cancers and cancer cell lines. The mutations render beta-catenin resistant to regulation by a complex containing the glycogen synthase kinase 3beta, adenomatous polyposis coli, and axin proteins. As a result, beta-catenin accumulates in the cytosol and nucleus and activates T-cell factor/ lymphoid enhancing factor transcription factors. Previously, 6 of 27 melanoma cell lines were found to have beta-catenin exon 3 mutations affecting the N-terminal phosphorylation sites (Rubinfeld B, Robbins P, Elgamil M, Albert I, Porfiri E, Polakis P: Stabilization of beta-catenin by genetic defects in melanoma cell lines. Science 1997, 275:1790-1792). To assess the role of beta-catenin defects in primary melanomas, we undertook immunohistochemical and DNA sequencing studies in 65 melanoma specimens. Nuclear and/or cytoplasmic localization of beta-catenin, a potential indicator of wnt pathway activation, was seen focally within roughly one third of the tumors, though a clonal somatic mutation in beta-catenin was found in only one case (codon 45 Ser-->Pro). Our findings demonstrate that beta-catenin mutations are rare in primary melanoma, in contrast to the situation in melanoma cell lines. Nonetheless, activation of beta-catenin, as indicated by its nuclear and/or cytoplasmic localization, appears to be frequent in melanoma, and in some cases, it may reflect focal and transient activation of the wnt pathway within the tumor. (+info)Interleukin-10-treated human dendritic cells induce a melanoma-antigen-specific anergy in CD8(+) T cells resulting in a failure to lyse tumor cells. (4/10127)
Dendritic cells (DC) are critically involved in the initiation of primary immune processes, including tumor rejection. In our study, we investigated the effect of interleukin-10 (IL-10)-treated human DC on the properties of CD8(+) T cells that are known to be essential for the destruction of tumor cells. We show that IL-10-pretreatment of DC not only reduces their allostimulatory capacity, but also induces a state of alloantigen-specific anergy in both primed and naive (CD45RA+) CD8(+) T cells. To investigate the influence of IL-10-treated DC on melanoma-associated antigen-specific T cells, we generated a tyrosinase-specific CD8(+) T-cell line by several rounds of stimulation with the specific antigen. After coculture with IL-10-treated DC, restimulation of the T-cell line with untreated, antigen-pulsed DC demonstrated peptide-specific anergy in the tyrosinase-specific T cells. Addition of IL-2 to the anergic T cells reversed the state of both alloantigen- or peptide-specific anergy. In contrast to optimally stimulated CD8(+) T cells, anergic tyrosinase-specific CD8(+) T cells, after coculture with peptide-pulsed IL-10-treated DC, failed to lyse an HLA-A2-positive and tyrosinase-expressing melanoma cell line. Thus, our data demonstrate that IL-10-treated DC induce an antigen-specific anergy in cytotoxic CD8(+) T cells, a process that might be a mechanism of tumors to inhibit immune surveillance by converting DC into tolerogenic antigen-presenting cells. (+info)Gardner's syndrome and steatocystoma multiplex. Two unusual genetically determined conditions occurring in same patient. (5/10127)
A 43-year-old man is described who had Gardner's syndrome and steatocystoma multiplex. These two unusual genetically determined conditions were associated because he had inherited the Gardner's syndrome from his father and the steatocystoma multiplex from his mother. (+info)MDM2 overexpression generates a skin phenotype in both wild type and p53 null mice. (6/10127)
The MDM2 proto-oncogene is overexpressed in human tumours and regulates the activities of the tumour suppressors p53 and pRB. We created mice that overexpress MDM2 under the control of the CMV promoter. These mice did not display an increased tumour incidence, but rather a specific skin phenotype, characterized by desquamation and hyperkeratosis. Transgenic MDM2 was found to be overexpressed in the epidermis, a tissue that normally expresses high levels of MDM2. The phenotype appeared during the first week after birth and then lessened with age, closely following the level of expression of the transgene. MDM2 overexpression was associated with an increase in proliferation in the basal layer, thickening of the epidermis, altered expression of the differentiation markers cytokeratin CK14, CK10 and CK1, and a decrease in the size and the number of granules that contain products of differentiation. Transgenic mice on a p53 null background displayed similar although not identical changes, showing that the effects of MDM2 are to a certain degree p53 independent. The skin is a major site of MDM2 expression in mice, raising the possibility that MDM2 overexpression perturbs the normal pattern of MDM2 expression and inhibits differentiation of the epidermis. (+info)Tumor suppression in human skin carcinoma cells by chromosome 15 transfer or thrombospondin-1 overexpression through halted tumor vascularization. (7/10127)
The development of skin carcinomas presently is believed to be correlated with mutations in the p53 tumor suppressor and ras gene as well as with the loss of chromosome 9. We now demonstrate that, in addition, loss of chromosome 15 may be a relevant genetic defect. Reintroduction of an extra copy of chromosome 15, but not chromosome 4, into the human skin carcinoma SCL-I cells, lacking one copy of each chromosome, resulted in tumor suppression after s.c. injection in mice. Transfection with thrombospondin-1 (TSP-1), mapped to 15q15, induced the same tumor suppression without affecting cell proliferation in vitro or in vivo. Halted tumors remained as small cysts encapsulated by surrounding stroma and blood vessels. These cysts were characterized by increased TSP-1 matrix deposition at the tumor/stroma border and a complete lack of tumor vascularization. Coinjection of TSP-1 antisense oligonucleotides drastically reduced TSP-1 expression and almost completely abolished matrix deposition at the tumor/stroma border. As a consequence, the tumor phenotype reverted to a well vascularized, progressively expanding, solid carcinoma indistinguishable from that induced by the untransfected SCL-I cells. Thus, these data strongly suggest TSP-1 as a potential tumor suppressor on chromosome 15. The data further propose an unexpected mechanism of TSP-1-mediated tumor suppression. Instead of interfering with angiogenesis in general, in this system TSP-1 acts as a matrix barrier at the tumor/stroma border, which, by halting tumor vascularization, prevents tumor cell invasion and, thus, tumor expansion. (+info)Glucocorticoid mediation of dietary energy restriction inhibition of mouse skin carcinogenesis. (8/10127)
Dietary energy restriction (DER) inhibits carcinogenesis in numerous animal models. DER is a potent and reproducible inhibitor of two-stage mouse skin carcinogenesis when administered during the promotion phase. Previous research demonstrated that adrenalectomy abolished cancer prevention by food restriction. Several lines of evidence suggest that glucocorticoid elevation in the DER mouse mediates the prevention of skin cancer. Our research tested the hypothesis that elevated glucocorticoid hormone activates the glucocorticoid receptor (GR) and that this activated receptor interferes with the activator protein-1 (AP-1) transcription factor. Induction of AP-1 by the phorbol ester tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) is essential to tumor promotion. We have been unable to demonstrate elevated activated GR in the epidermis of the DER mouse, perhaps because only indirect strategies have been possible with the use of epidermis from DER mice. However, DER blocked the induction of AP-1 and c-jun, a constituent protein of AP-1, in the epidermis of mice. Current studies are focused on the inhibition of signaling down the MAP-1/Raf-1 kinase pathway that leads to induction of constituent proteins of AP-1, including c-Jun. Although several pathways lead to the induction of AP-1 transcriptional activity, the MAP-1/Raf-1 pathway can be activated by protein kinase C (PKC); previous studies from our laboratory demonstrated an inhibition of PKC activity and a reduction in selected isoforms of PKC in the epidermis of the DER mouse. Our current working hypothesis is that elevated glucocorticoid hormone in the DER mouse reduces the amount and activity of PKC isoforms important in the activation of MAP-1/Raf-1 kinase pathway. We propose that this results in attenuation in the induction of the AP-1 transcription factor by TPA. Because AP-1 induction by TPA is obligatory for mouse skin promotion, we propose this as an essential component of the mechanism of DER prevention of mouse skin carcinogenesis. (+info)Keratoacanthoma is a rapidly growing, well-differentiated, low-grade squamous cell carcinoma that usually presents as a solitary nodule with a central keratin-filled crater, primarily occurring on sun-exposed areas of the skin in elderly individuals.
Keratoacanthoma is a rapidly growing, dome-shaped, skin tumor that typically arises on sun-exposed areas such as the face, arms, and legs. It is considered a low-grade squamous cell carcinoma (a type of skin cancer) because it shares some characteristics with both benign and malignant tumors.
Keratoacanthomas usually develop over a period of several weeks to months, growing rapidly in size before eventually stabilizing and then gradually regressing on their own within a few months to a year. However, the regression process can take years, and some lesions may not regress completely, leading to cosmetic concerns or even local invasion.
Histologically, keratoacanthomas are characterized by a central keratin-filled crater surrounded by a well-differentiated layer of squamous epithelial cells. The tumor's growth pattern and histological features can make it difficult to distinguish from other types of skin cancer, such as squamous cell carcinoma.
Treatment options for keratoacanthomas include surgical excision, cryosurgery, curettage and electrodesiccation, and topical therapies like imiquimod or 5-fluorouracil. The choice of treatment depends on various factors such as the size, location, and number of lesions, as well as patient preferences and overall health status.
Skin neoplasms are abnormal growths or tumors of the skin that can be benign (non-cancerous) or malignant (cancerous), originating from the skin's epidermis, dermis, or subcutaneous tissue.
Skin neoplasms refer to abnormal growths or tumors in the skin that can be benign (non-cancerous) or malignant (cancerous). They result from uncontrolled multiplication of skin cells, which can form various types of lesions. These growths may appear as lumps, bumps, sores, patches, or discolored areas on the skin.
Benign skin neoplasms include conditions such as moles, warts, and seborrheic keratoses, while malignant skin neoplasms are primarily classified into melanoma, squamous cell carcinoma, and basal cell carcinoma. These three types of cancerous skin growths are collectively known as non-melanoma skin cancers (NMSCs). Melanoma is the most aggressive and dangerous form of skin cancer, while NMSCs tend to be less invasive but more common.
It's essential to monitor any changes in existing skin lesions or the appearance of new growths and consult a healthcare professional for proper evaluation and treatment if needed.
"Skin is the largest organ of the human body, acting as a protective barrier and involved in sensory perception, temperature regulation, and immune function."
In medical terms, the skin is the largest organ of the human body. It consists of two main layers: the epidermis (outer layer) and dermis (inner layer), as well as accessory structures like hair follicles, sweat glands, and oil glands. The skin plays a crucial role in protecting us from external factors such as bacteria, viruses, and environmental hazards, while also regulating body temperature and enabling the sense of touch.
'Skin diseases' is a broad term for various conditions affecting the skin, including inflammatory disorders, infections, benign and malignant tumors, congenital abnormalities, and degenerative diseases, which can cause symptoms such as rashes, discoloration, eruptions, lesions, itching, or pain.
Skin diseases, also known as dermatological conditions, refer to any medical condition that affects the skin, which is the largest organ of the human body. These diseases can affect the skin's function, appearance, or overall health. They can be caused by various factors, including genetics, infections, allergies, environmental factors, and aging.
Skin diseases can present in many different forms, such as rashes, blisters, sores, discolorations, growths, or changes in texture. Some common examples of skin diseases include acne, eczema, psoriasis, dermatitis, fungal infections, viral infections, bacterial infections, and skin cancer.
The symptoms and severity of skin diseases can vary widely depending on the specific condition and individual factors. Some skin diseases are mild and can be treated with over-the-counter medications or topical creams, while others may require more intensive treatments such as prescription medications, light therapy, or even surgery.
It is important to seek medical attention if you experience any unusual or persistent changes in your skin, as some skin diseases can be serious or indicative of other underlying health conditions. A dermatologist is a medical doctor who specializes in the diagnosis and treatment of skin diseases.
"Skin aging is a complex biological process characterized by various intrinsic and extrinsic factors, resulting in changes such as fine lines, wrinkles, dryness, and pigmentary alterations over time."
Skin aging, also known as cutaneous aging, is a complex and multifactorial process characterized by various visible changes in the skin's appearance and function. It can be divided into two main types: intrinsic (chronological or natural) aging and extrinsic (environmental) aging.
Intrinsic aging is a genetically determined and time-dependent process that results from internal factors such as cellular metabolism, hormonal changes, and genetic predisposition. The primary features of intrinsic aging include gradual thinning of the epidermis and dermis, decreased collagen and elastin production, reduced skin cell turnover, and impaired wound healing. Clinically, these changes present as fine wrinkles, dryness, loss of elasticity, and increased fragility of the skin.
Extrinsic aging, on the other hand, is caused by external factors such as ultraviolet (UV) radiation, pollution, smoking, alcohol consumption, and poor nutrition. Exposure to these environmental elements leads to oxidative stress, inflammation, and DNA damage, which accelerate the aging process. The main features of extrinsic aging are coarse wrinkles, pigmentary changes (e.g., age spots, melasma), irregular texture, skin laxity, and increased risk of developing skin cancers.
It is important to note that intrinsic and extrinsic aging processes often interact and contribute to the overall appearance of aged skin. A comprehensive approach to skincare should address both types of aging to maintain healthy and youthful-looking skin.
Pancreatic neoplasms are abnormal growths of tissue in the pancreas that can be benign or malignant, often characterized by progressive and invasive growth which can interfere with normal endocrine and exocrine functions, leading to serious health consequences if not detected and treated early.
Pancreatic neoplasms refer to abnormal growths in the pancreas that can be benign or malignant. The pancreas is a gland located behind the stomach that produces hormones and digestive enzymes. Pancreatic neoplasms can interfere with the normal functioning of the pancreas, leading to various health complications.
Benign pancreatic neoplasms are non-cancerous growths that do not spread to other parts of the body. They are usually removed through surgery to prevent any potential complications, such as blocking the bile duct or causing pain.
Malignant pancreatic neoplasms, also known as pancreatic cancer, are cancerous growths that can invade and destroy surrounding tissues and organs. They can also spread (metastasize) to other parts of the body, such as the liver, lungs, or bones. Pancreatic cancer is often aggressive and difficult to treat, with a poor prognosis.
There are several types of pancreatic neoplasms, including adenocarcinomas, neuroendocrine tumors, solid pseudopapillary neoplasms, and cystic neoplasms. The specific type of neoplasm is determined through various diagnostic tests, such as imaging studies, biopsies, and blood tests. Treatment options depend on the type, stage, and location of the neoplasm, as well as the patient's overall health and preferences.
Neoplasms are abnormal growths of cells or tissues that form tumors, which can be benign (noncancerous) or malignant (cancerous), and have the potential to invade local tissues and spread to distant sites in the body.
Neoplasms are abnormal growths of cells or tissues in the body that serve no physiological function. They can be benign (non-cancerous) or malignant (cancerous). Benign neoplasms are typically slow growing and do not spread to other parts of the body, while malignant neoplasms are aggressive, invasive, and can metastasize to distant sites.
Neoplasms occur when there is a dysregulation in the normal process of cell division and differentiation, leading to uncontrolled growth and accumulation of cells. This can result from genetic mutations or other factors such as viral infections, environmental exposures, or hormonal imbalances.
Neoplasms can develop in any organ or tissue of the body and can cause various symptoms depending on their size, location, and type. Treatment options for neoplasms include surgery, radiation therapy, chemotherapy, immunotherapy, and targeted therapy, among others.
An Acanthoma is a benign skin condition characterized by the formation of an irregular, thickened patch or nodule on the epidermis, often as a result of abnormal keratinocyte proliferation.
An acanthoma is a benign skin tumor characterized by the proliferation of epidermal cells, specifically the pickle cell layer (stratum spinosum). The term "acanthoma" comes from the Greek word "akantha," which means "thorn" or "spine."
There are several types of acanthomas, including:
1. Seborrheic keratosis: Also known as seborrheic warts, these are common benign growths that appear as rough, scaly patches on the skin. They can be tan, brown, or black and may have a waxy or greasy appearance.
2. Benign lichenoid keratosis: These are small, flat lesions with a scaly surface that typically occur on sun-exposed areas of the skin. They are usually asymptomatic but may occasionally itch.
3. Psoriasiform acanthoma: This is a rare type of acanthoma that resembles psoriasis, a chronic skin condition characterized by red, scaly patches.
4. Clear cell acanthoma: This is a distinctive type of acanthoma that appears as a solitary, dome-shaped nodule with a smooth surface and a central crust. It typically occurs on the lower legs of older adults.
Acanthomas are generally harmless and do not require treatment unless they become irritated or unsightly. In such cases, they can be removed through various methods, including cryosurgery (freezing), curettage (scraping), or excision (cutting).
A medical dictionary is a specialized reference book containing terms, definitions, and explanations related to medical science, healthcare practices, and associated disciplines, used by healthcare professionals, students, researchers, and patients to enhance understanding of medical concepts and terminology.
A medical dictionary is a reference book that contains definitions and explanations of medical terms and jargon. It serves as a useful tool for healthcare professionals, students, patients, and anyone else who needs to understand medical terminology. Medical dictionaries can include definitions of diseases, conditions, treatments, procedures, drugs, equipment, anatomy, and more. They may also provide pronunciation guides, etymologies, and abbreviations.
Medical dictionaries can be found in print or digital form, and some are specialized to cover specific areas of medicine, such as oncology, psychiatry, or surgery. Some medical dictionaries are also bilingual, providing translations of medical terms between different languages. Overall, a medical dictionary is an essential resource for anyone who needs to communicate effectively in the field of medicine.
Malignant atrophic papulosis (Kohlmeier-Degos disease) is a rare, progressive cutaneous vasculopathy characterized by the development of porcelain-white atrophic macules, surrounded by erythematous borders, and evolving into necrotic papules or pustules, which can lead to systemic involvement of internal organs.
Malignant atrophic papulosis (MAP), also known as Kohlmeier-Degos disease, is a rare and progressive cutaneous vasculopathy of unknown etiology. It is characterized by the development of porcelain-white atrophic macules, which evolve into papules with a central necrotic depression or ulceration, surrounded by an erythematous halo. The lesions typically appear on the trunk and extremities, but may also affect mucous membranes, gastrointestinal tract, and other organs.
MAP is considered to be a chronic inflammatory disorder that affects small-sized blood vessels, leading to tissue ischemia and necrosis. The disease can have a variable clinical course, ranging from self-limited cutaneous involvement to systemic manifestations with potentially life-threatening complications.
The diagnosis of MAP is based on the clinical presentation, histopathological findings, and exclusion of other similar conditions. Treatment options for MAP are limited, and there is no cure for this disease. The management typically involves a multidisciplinary approach to address the various organ manifestations and prevent complications.
"Encyclopedias, as a medical topic, refer to comprehensive and organized collections of information on various medical disciplines, theories, practices, diseases, treatments, and related health sciences, serving as extensive reference sources for medical professionals, students, researchers, and general public." (29 words)
An encyclopedia is a comprehensive reference work containing articles on various topics, usually arranged in alphabetical order. In the context of medicine, a medical encyclopedia is a collection of articles that provide information about a wide range of medical topics, including diseases and conditions, treatments, tests, procedures, and anatomy and physiology. Medical encyclopedias may be published in print or electronic formats and are often used as a starting point for researching medical topics. They can provide reliable and accurate information on medical subjects, making them useful resources for healthcare professionals, students, and patients alike. Some well-known examples of medical encyclopedias include the Merck Manual and the Stedman's Medical Dictionary.
Acanthoma
An acanthoma is a skin neoplasm composed of squamous or epidermal cells. It is located in the prickle cell layer. Types of ... In 2005, "Acanthoma" was added to MeSH as an index term; previous indexing was "Skin Neoplasms" (1965-2004). At that time, ...
Mouse model of colorectal and intestinal cancer
1996). "Spontaneous intestinal carcinomas and skin neoplasms in Msh2-deficient mice". Cancer Res. 56 (16): 3842-9. PMID 8706033 ...
Human skin
Diseases of the skin include skin infections and skin neoplasms (including skin cancer). Dermatology is the branch of medicine ... Human skin is similar to most of the other mammals' skin, and it is very similar to pig skin. Though nearly all human skin is ... especially pig skin. Pig skin shares similar epidermal and dermal thickness ratios to human skin; pig and human skin share ... hairy and glabrous skin (hairless). The adjective cutaneous literally means "of the skin" (from Latin cutis, skin). Skin plays ...
Hidradenoma
Obaidat NA, Alsaad KO, Ghazarian D (February 2007). "Skin adnexal neoplasms--part 2: an approach to tumours of cutaneous sweat ... Tumours of the Skin Appendages: Eccrine gland tumours". Rook's Textbook of Dermatology (8th ed.). Chichester, West Sussex: John ... It usually presents as a single, small skin-colored lesion, and may be considered closely related to or a variant of poromas. ... Tumours of the Skin Appendages: Eccrine or aprocrine/follicular tumours". Rook's Textbook of Dermatology (8th ed.). Chichester ...
Skin condition
Diseases of the skin include skin infections and skin neoplasms (including skin cancer). In 1572, Geronimo Mercuriali of Forlì ... The two main types of human skin are glabrous skin, the nonhairy skin on the palms and soles (also referred to as the " ... Atrophy refers to a loss of skin, and can be epidermal, dermal, or subcutaneous. With epidermal atrophy, the skin appears thin ... Dermal or subcutaneous atrophy is represented by depression of the skin. Maceration: softening and turning white of the skin ...
Malignant chondroid syringoma
Obaidat NA, Alsaad KO, Ghazarian D (February 2007). "Skin adnexal neoplasms--part 2: an approach to tumours of cutaneous sweat ... List of cutaneous conditions Neoplasm James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: ... The rare neoplasms generally do not follow a determinate development path and are often difficult to diagnose. Histologically, ... The masses were described as skin lesions that had developed in a nodular fashion on the patient's right arm. To remove the ...
Trichoepithelioma
... is a neoplasm of the adnexa of the skin. Its appearance is similar to basal cell carcinoma. One form has been ... 2006). Andrews' Diseases of the Skin: Clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0. Stanoszek, Lauren M.; Wang, ... Articles with short description, Short description is different from Wikidata, Epidermal nevi, neoplasms, and cysts). ... Trichoblastoma Pilomatricoma CYLD cutaneous syndrome List of cutaneous conditions List of cutaneous neoplasms associated with ...
Pathology
More than 1500 different disorders of the skin exist, including cutaneous eruptions ("rashes") and neoplasms. Therefore, ... Sometimes, however, those criteria do not lead to a conclusive diagnosis, and a skin biopsy is taken to be examined under the ... Excisional biopsies of skin lesions and gastrointestinal polyps are very common. The pathologist's interpretation of a biopsy ... Dermatopathology is a subspecialty of anatomic pathology that focuses on the skin and the rest of the integumentary system as ...
Trichoblastoma
... s are a skin condition characterized by benign neoplasms of the follicular germinative cells known as ... Skin lesion List of cutaneous conditions List of cutaneous conditions associated with increased risk of nonmelanoma skin cancer ... v t e (Articles with short description, Short description matches Wikidata, Epidermal nevi, neoplasms, and cysts, All stub ... 2006). Andrews' Diseases of the Skin: Clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0. Rapini, Ronald P.; Bolognia ...
Extramammary Paget's disease
In these cases an involvement of the skin by a noncutaneous internal neoplasm may occur. EMPD occurs due to an invasion of the ... The lesion is clearly separated from normal skin in most cases, and sometimes scattered areas of white scale can be present, ... neoplasms, and cysts, Rare diseases, Diseases named for discoverer). ...
CYLD cutaneous syndrome
Genetic Tests which analyzed skin tumors rather than blood leukocytes, analyzed two or more skin tumors or blood leucocyte ... Articles with short description, Short description is different from Wikidata, Epidermal nevi, neoplasms, and cysts, Conditions ... Trichoepithelioma-like CCS tumors appear as skin-coloured, small, papules usually located in the skin around the nose, ... These individuals have skin tumors that tend to cluster into MFT1, BSS, and/or FC types that differ form each other in their ...
Spiradenoma
Areas of the skin that do not have hair follicles (e.g. palms of the hands and soles of feet) do not develop these nodules. ... "Current Diagnosis and Treatment Options for Cutaneous Adnexal Neoplasms with Apocrine and Eccrine Differentiation". ... SA tumors usually occur as slow-growing, single, small, nodular lesions located in the skin of the head, neck, or trunk. SAC ... Individuals with CCS commonly develop an increasingly large number of skin tumors, including SA and SAC, over time. Usually, ...
Eumycetoma
... a vascular tumour of skin usually seen in AIDS. Leprosy Syphilis Malignant neoplasm Tropical ulcer Botryomycosis, a skin ... Eumycetoma, also known as Madura foot, is a persistent fungal infection of the skin and the tissues just under the skin, ... The initial lesion is a small swelling under the skin following minor trauma. It appears as a painless wet nodule, which may be ... "Skin-nontumor Infectious disorders Botryomycosis". PathologyOutlines.com, Inc. Archived from the original on 24 July 2012. ...
Skin cancer in horses
Sarcoids are the most common type of skin neoplasm and are the most common type of cancer overall in horses. Squamous-cell ... Exposure of light-colored skin to UV light has often been cited as a predisposing factor, but lesions can occur in dark skin ... but they are most often located in non-pigmented skin near mucocutaneous junctions (where skin meets mucous membranes) such as ... Skin cancer, or neoplasia, is the most common type of cancer diagnosed in horses, accounting for 45 to 80% of all cancers ...
Corticosteroid
... ranging from hematological neoplasms to brain tumors or skin diseases. Dexamethasone and its derivatives are almost pure ... When topical steroid medication is lost, the skin experiences redness, burning, itching, hot skin, swelling, and/or oozing for ... For use topically on the skin, eye, and mucous membranes. Topical corticosteroids are divided in potency classes I to IV in ... This is also called 'red skin syndrome' or 'topical steroid withdrawal' (TSW). After the withdrawal period is over the atopic ...
Laugier-Hunziker syndrome
Melanocytic nevi and neoplasms, Syndromes affecting the skin, All stub articles, Dermatology stubs). ...
Nevus spilus
Melanocytic nevi and neoplasms". Andrews' Diseases of the Skin: Clinical Dermatology (13th ed.). Edinburgh: Elsevier. pp. 686- ... Lentigines, nevi and melanomas". Weedon's Skin Pathology Essentials (2nd ed.). Elsevier. p. 530. ISBN 978-0-7020-6830-0. DE, ... Prevalence is between 0.2% and 2.8%. Phakomatosis pigmentokeratotica Skin lesion List of cutaneous conditions James, William D ... Elder; D, Massi; RA, Scolyer; R, Willemze (2018). "2. Melanocytic tumours:Nevus spilus". WHO Classification of Skin Tumours. ...
Sebaceous carcinoma
SGc accounts for approximately 0.7% of all skin cancers and 0.2 to 4.6% of all malignant cutaneous neoplasms. Notable risk ... ulcerated papule on the head or neck and may mimic nonmelanoma skin cancers, molluscum contagiosum, adnexal neoplasms, or ... SGc accounts for approximately 0.7% of all skin cancers, and the incidence of SGc is highest in Caucasian, Asian, and Indian ... The incidence of MTS in patients with sebaceous neoplasms as high as 14 to 50%. Besides mutations in mismatch repair genes, Wnt ...
Neoplasms of the nailbed
v t e (All stub articles, Condition of the skin appendages stubs, Conditions of the skin appendages). ... Neoplasms of the nailbed may often present with paronychia, ingrown nail, onycholysis, pyogenic granuloma, nail-plate dystrophy ... Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. ISBN 0-7216-2921-0. "Nails Matsun Supplement". Matsun ... longitudinal erythronychia, bleeding, and discolorations.: 792 There are various benign and malignant neoplasms that may occur ...
Dysplastic nevus syndrome
Melanocytic nevi and neoplasms, Syndromes affecting the skin). ... Monthly self-performed skin examinations and early referral to ... Screening for melanoma in FAMMM kindreds should begin at age 10 with a baseline total body skin examination including scalp, ... Treatment consists of resection of malignant skin lesions (melanoma). Screening for pancreatic cancer may be considered, ... 2006). Andrews' Diseases of the Skin: Clinical Dermatology. Saunders Elsevier. ISBN 978-0-7216-2921-6. Czajkowski, R., FAMMM ...
Carney complex
Melanocytic nevi and neoplasms, Syndromes affecting the skin, Syndromes affecting the heart, Syndromes with tumors). ... The spotty skin pigmentation and lentigines occur most commonly on the face, especially on the lips, eyelids, conjunctiva and ... Myxomas may also occur outside the heart, usually in the skin and breast. Endocrine tumors may manifest as disorders such as ... hyperpigmentation of the skin (lentiginosis), and endocrine overactivity. It is distinct from Carney's triad. Approximately 7% ...
List of skin conditions
... neoplasms, and cysts are skin lesions that develop from the epidermal layer of the skin. Aberrant basal cell carcinoma ... Peeling skin syndrome (acral peeling skin syndrome, continual peeling skin syndrome, familial continual skin peeling, ... The two main types of human skin are: glabrous skin, the hairless skin on the palms and soles (also referred to as the " ... primary neuroendocrine carcinoma of the skin, primary small cell carcinoma of the skin, trabecular carcinoma of the skin) ...
List of MeSH codes (C04)
... skin appendage MeSH C04.557.470.565 - neoplasms, basal cell MeSH C04.557.470.565.165 - carcinoma, basal cell MeSH C04.557. ... skull base neoplasms MeSH C04.588.149.828 - spinal neoplasms MeSH C04.588.180.260 - breast neoplasms, male MeSH C04.588.180.390 ... bile duct neoplasms MeSH C04.588.274.120.250.250 - common bile duct neoplasms MeSH C04.588.274.120.401 - gallbladder neoplasms ... femoral neoplasms MeSH C04.588.149.721 - skull neoplasms MeSH C04.588.149.721.450 - jaw neoplasms MeSH C04.588.149.721.450.583 ...
Rombo syndrome
... conditions List of cutaneous conditions associated with increased risk of nonmelanoma skin cancer List of cutaneous neoplasms ... The skin atrophy was referred to as vermiculate atrophoderma. Basal cell carcinomas may develop around the age of 35. ... James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders ... somewhat cyanotic redness of the lips and hands was evident as well as moderate follicular atrophy of the skin on the cheeks. ...
Comorbidity
In the comorbid structure of these patients, most frequently present are malignant neoplasms, locomotorium disorders, skin and ... Greenfield to evaluate comorbidity in patients with malignant neoplasms, later it also became useful for other categories of ... advantage of the Kaplan-Feinstein Index as compared to CIRS is in the capability of independent analysis of malignant neoplasms ...
Liver spot
Melanocytic nevi and neoplasms, Human skin color). ... Skin-bleaching products that inhibit pigmentation or cosmetic ... taken from human skin biopsies of patients facial senile lentigo of Fitzpatrick skin type III or IV aged 55-62 are enriched ... From the age of 40, the skin is less able to regenerate from sun exposure, and liver spots are very common in this age group, ... Differently from the melanotic nevi and the verrucous nevi on the skin, age spots change in color and in shape with time. ...
List of ICD-9 codes 140-239: neoplasms
Malignant melanoma of skin 173 Other malignant neoplasm of skin 174 Malignant neoplasm of female breast 175 Malignant neoplasm ... 140 Malignant neoplasm of lip 141 Malignant neoplasm of tongue 142 Malignant neoplasm of major salivary glands 143 Malignant ... 215 Other benign neoplasm of connective and other soft tissue 216 Benign neoplasm of skin Melanocytic nevus 217 Benign neoplasm ... benign neoplasm of uterus 220 Benign neoplasm of ovary 221 Benign neoplasm of other female genital organs 222 Benign neoplasm ...
STK11
... pigmented macules on the skin and mouth, and other neoplasms. However, the LKB1 gene was also found to be mutated in lung ... December 2001). "STK11/LKB1 Peutz-Jeghers gene inactivation in intraductal papillary-mucinous neoplasms of the pancreas". The ... pancreatic and skin cancer. LKB1 has been implicated as a potential target for inducing cardiac regeneration after injury as ...
Oral pigmentation
HIV Antimalarial drug therapy This is an intermediate neoplasm which affects the skin and mucous membranes; usually arising in ... of the population and is most likely seen in those with dark skin; however people with light skin have, on average, 30 local ... Due to this, dark pigmentation may be visible on the oral mucosa or skin. Most common oral sites include: buccal mucosa, lips, ... Nevus cells in the skin and oral mucosa also produce melanin. Oral melanosis can present as black, gray, blue or brown lesions ...
Neoplasm
... skin moles). They are circumscribed and localized and do not transform into cancer. Potentially-malignant neoplasms include ... ICD-10 classifies neoplasms into four main groups: benign neoplasms, in situ neoplasms, malignant neoplasms, and neoplasms of ... The word neoplasm is from Ancient Greek νÎος- neo 'new' and πλάσμα plasma 'formation, creation'. A neoplasm can be benign, ... The process that occurs to form or produce a neoplasm is called neoplasia. The growth of a neoplasm is uncoordinated with that ...
Information for Benign neoplasm of skin
Mesenchymal Neoplasms Affecting the Skin and Subcutaneous Tissues in the Dog and Cat<...
Mesenchymal Neoplasms Affecting the Skin and Subcutaneous Tissues in the Dog and Cat. / Fan, Timothy M. Small Animal ... Mesenchymal Neoplasms Affecting the Skin and Subcutaneous Tissues in the Dog and Cat. In Small Animal Dermatology Secrets. ... Fan, T. M. (2003). Mesenchymal Neoplasms Affecting the Skin and Subcutaneous Tissues in the Dog and Cat. In Small Animal ... Fan, TM 2003, Mesenchymal Neoplasms Affecting the Skin and Subcutaneous Tissues in the Dog and Cat. in Small Animal Dermatology ...
Skin Diseases - Skin Neoplasms | CU Experts | CU Boulder
Skin Diseases - Skin Neoplasms PubMed MeSh Term *Overview. Overview. subject area of * A cornucopia of human polyomaviruses ... MicroRNA-mediated control in the skin Journal Article * Number of Nevi and early-life ambient UV exposure are associated with ... Global mortality from conditions with skin manifestations Journal Article * Interaction of CDKN2A and Sun Exposure in the ... The experience of outdoor physical activity for skin cancer survivors: understanding the importance of the built and natural ...
Skin, benign neoplasm - CCMDB Wiki
Endocrine neoplasm, Exposure, Eye, Female genital neoplasm, Fistula, Fracture, Fungus, GI ulcer, Gastroenteritis, ... Retrieved from "https://ccmdb.kuality.ca/index.php?title=Skin,_benign_neoplasm&oldid=160251" ... Male genital neoplasm, Mechanism, Meningitis, Metabolic/nutrition, Metastasis, Misc, Muscle problem, Muscles/tendon trauma, ... Benign neoplasm, Breast disease, Burn, COVID, Cannabis related, Cardiac septum problem, Cardiovascular, Cerebral Hemorrhage/ ...
Sentinel Lymph Node Biopsy in Nonmelanoma Skin Cancer Patients
... and other rare skin neoplasms have a well-known risk to spread to regional lymph nodes. The use of sentinel lymph node biopsy ( ... We observed overall 30.8% positive SNs in 13 consecutive patients operated for high-risk nonmelanoma skin cancer between ... These high rates support recommendation to implement SLNB for nonmelanoma skin cancer especially for SCC patients. Completion ... SLNB has allowed sparing a lot of morbidity and could therefore be used in nonmelanoma skin cancer patients, even though a ...
Pathology of Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN): Overview, Definition and Epidemiology, Clinical Features
Plasmacytoid monocytes are seen in blastic plasmacytoid dendritic cell (BPDC) neoplasm; and myeloid cells are seen in stem cell ... Myeloid-related precursor neoplasms derive from precursor cells that have at least one form of myeloid differentiation. ... CD56-positive haematological neoplasms of the skin: a multicentre study of the Cutaneous Lymphoma Project Group of the European ... Frequent sites of occurrence of blastic plasmacytoid dendritic cell neoplasm (BPDCN) include the skin, as well as the ...
Malignant neoplasm of skin (Concept Id: C0007114)
- MedGen - NCBI
Primary malignant skin neoplasms most often are carcinomas (either basal cell or squamous cell carcinomas) or melanomas. ... Metastatic malignant neoplasms to the skin include carcinomas and lymphomas. ... A primary or metastatic malignant neoplasm involving the skin. ... Malignant skin neoplasm; Skin cancer. SNOMED CT: Malignant ... Neoplasm*Malignant neoplastic disease*Malignant neoplasm of skin*CD4+/CD56+ hematodermic neoplasm*Recurrent Blastic ...
October 1976 - Volume 58 - Issue 4 : Plastic and Reconstructive Surgery
NEOPLASMS: Benign, Clinical study of liquid nitrogen spray technique on various skin lesions. (Japanese). M, Seki; Fukuda, ... NECK: Neoplasms, Combined approach for massive nasopharyngeal fibroma. Rege, S. R.; Shah, K. L.; Kantawala, S. A.; More ... GRAFTS AND FLAPS: Skin, Somersault flap as a substitute for the cross-leg flap. P, Lemos; Guerrero-Santos, José ... NEOPLASMS: Malignant, Adeno-cystic carcinoma of the scalp with pulmonary metastasis. Sanderson, K. V.; Batten, J. C.; Wood, ...
Skin Cancer Types (Nonmelanoma) | Moffitt
Click here to explore the various types of nonmelanoma skin cancer, all of which can be diagnosed and treated at Moffitt Cancer ... The skin lesion often looks red and scaly, similar to eczema.. Skin adnexal neoplasm. These tumors originate in the hair ... When sarcomas develop in the skin, theyre referred to as cutaneous sarcomas or skin sarcomas. These sarcomas of the skin often ... This skin cancer can appear as a firm lesion on the skin. These lesions can appear in various sizes and are typically red, blue ...
Skin Cancer | Basal Cell Carcinoma | MedlinePlus
Try ABCDE on a mole to check for signs of skin cancer: Asymmetry, Border, Color, Diameter, Elevation. Learn more on advanced ... ClinicalTrials.gov: Skin Neoplasms (National Institutes of Health) Journal Articles References and abstracts from MEDLINE/ ... Skin Cancer Screening (National Library of Medicine) Also in Spanish * Skin Cancer Screening (National Cancer Institute) Also ... Stages of Skin Cancer (National Cancer Institute) Also in Spanish * Tests for Basal and Squamous Cell Skin Cancers (American ...
ICD-10 Code for Malignant neoplasm of external lower lip- C00.1- Codify by AAPC
ICD-10 code C00.1 for Malignant neoplasm of external lower lip is a medical classification as listed by WHO under the range - ... other and unspecified malignant neoplasm of skin of lip (C44.0-). Use additional code to identify:. alcohol abuse and ... Malignant neoplasm of external lower lip Malignant neoplasm of lower lip NOS. Malignant neoplasm of lipstick area of lower lip ... Neoplasm of uncertain behavior versus neoplasm of unspecified behavior. [I]Any[/I] ICD-10 code from chapter 2 (neoplasms C00- ...
A case of blastic plasmacytoid dendritic cell neoplasm involving the skin<...
A case of blastic plasmacytoid dendritic cell neoplasm involving the skin. In: Japanese Journal of Cancer and Chemotherapy. ... A case of blastic plasmacytoid dendritic cell neoplasm involving the skin. Japanese Journal of Cancer and Chemotherapy. 2013 ... A case of blastic plasmacytoid dendritic cell neoplasm involving the skin. Shota Fukuoka, Yoshitaka Miyakawa, Takahiro Suzuki, ... Dive into the research topics of A case of blastic plasmacytoid dendritic cell neoplasm involving the skin. Together they ...
Prognostic factors related to clinical response in patients with metastatic melanoma treated by CTL-associated antigen-4...
38 CFR § 4.118 - Schedule of ratings-skin. | Electronic Code of Federal Regulations (e-CFR) | US Law | LII / Legal Information...
7819 Benign skin neoplasms: Rate as disfigurement of the head, face, or neck (DC 7800), scars (DCs 7801, 7802, 7803, 7804, or ... 4.25 only if separate areas of skin are involved. If two or more skin conditions involve the same area of skin, then only the ... 7818 Malignant skin neoplasms (other than malignant melanoma): Rate as disfigurement of the head, face, or neck (DC 7800), ... other than the skin, and topical therapy is treatment that is administered through the skin. ...
Acanthoma - Wikipedia
Imiquimod induced regression of clinically diagnosed superficial basal cell carcinoma is associated with early infiltration by...
A study of tumor progression: the precursor lesions of superficial spreading and nodular melanoma
Maraviroc: Package Insert - Drugs.com
... squamous cell carcinoma of skin, tongue neoplasm (malignant stage unspecified), anaplastic large cell lymphomas T- and null- ... Severe skin rash and allergic reactions. Severe and potentially life-threatening skin reactions and allergic reactions have ... 5.2 Severe Skin and Hypersensitivity Reactions. Severe, potentially life-threatening skin and hypersensitivity reactions have ... Neoplasms Benign, Malignant, and Unspecified (Including Cysts and Polyps):Abdominal neoplasm, anal cancer, basal cell carcinoma ...
Regulations - WTC Health Program
Malignant neoplasms of the skin (melanoma and non-melanoma), including scrotal cancer. ... Malignant neoplasm of the urinary bladder.. * Malignant neoplasm of the kidney.. * Malignant neoplasms of the renal pelvis; ... Malignant neoplasm of the thyroid.. * Malignant neoplasms of the blood and lymphoid tissues (including, but not limited to, ... Malignant neoplasms of the liver and intrahepatic bile duct.. * Malignant neoplasms of the retroperitoneum and peritoneum; ...
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Spencer Wells (Author of The Journey of Man)
Nonmelanoma Skin Cancer- Epidemiology Forecast to 2032
Nonmelanoma Skin Cancer - Epidemiology Forecast to 2032 report delivers an in-depth understanding of the disease, historical ... Skin Neoplasms - Epidemiology Forecast to 2032. January, 2022 , Published by: DelveInsight , USD $3,950 ... 2. Executive Summary of Nonmelanoma Skin Cancer. 3. Nonmelanoma Skin Cancer: Disease Background and Overview. 3.1. Introduction ... Nonmelanoma Skin Cancer Treatment and Management. 6.2. Nonmelanoma Skin Cancer Treatment Algorithm. 7. KOL Views. 8. Unmet ...
Advanced Search Results - Public Health Image Library(PHIL)
Glatopa (glatiramer acetate Injection): Uses, Dosage, Side Effects, Interactions, Warning
... benign skin neoplasm, skin carcinoma, skin striae, and vesiculobullous rash. ... Damage to your skin. Damage to the fatty tissue just under your skins surface (lipoatrophy) and, rarely, death of your skin ... Frequent: Eczema, herpes zoster, pustular rash, skin atrophy, and warts.. Infrequent: Dry skin, skin hypertrophy, dermatitis, ... Lipoatrophy And Skin Necrosis. At injection sites, localized lipoatrophy and, rarely, injection site skin necrosis may occur. ...
The EPA National Library Catalog | EPA National Library Network | US EPA
Dermatologic Surgery and Cutaneous Oncology | Dermatology
The Dermatologic and Laser Surgery Unit focuses on skin conditions amenable to surgical or laser intervention. The keystone of ... The Dermatologic and Laser Surgery Unit focuses on skin conditions amenable to surgical or laser intervention. The keystone of ... Sophisticated approaches for the management of other complicated or rare skin cancers are also provided. ... applied specifically for recurrent or other high-risk skin cancers. ...
Connie Rong Shi, M.D. | Harvard Catalyst Profiles | Harvard Catalyst
Biblio | Page 9 | Linus Pauling Institute | Oregon State University
Skin Neoplasms. Siddens LK, Bunde KL, Harper TA, McQuistan TJ, Löhr CV, Bramer LM, Waters KM, Tilton SC, Krueger SK, Williams ... Cytochrome P450 1b1 in polycyclic aromatic hydrocarbon (PAH)-induced skin carcinogenesis: Tumorigenicity of individual PAHs and ... Cytochrome P450 1b1 in polycyclic aromatic hydrocarbon (PAH)-induced skin carcinogenesis: Tumorigenicity of individual PAHs and ... Cytochrome P450 1b1 in polycyclic aromatic hydrocarbon (PAH)-induced skin carcinogenesis: Tumorigenicity of individual PAHs and ...
Christine Ko, MD | Yale School of Medicine
Skin Neoplasms; Neoplasms, Adnexal and Skin Appendage; Vascular Neoplasms ... Chapter 1 The basics Diagnostic terms, skin anatomy, and stainsFerringer T, Ko C. Chapter 1 The basics Diagnostic terms, skin ... Chapter 1 The basics: diagnostic terms, skin anatomy, and stainsFerringer T, Ko C. Chapter 1 The basics: diagnostic terms, skin ... I am studying skin cancer, particularly squamous cell carcinoma and keratoacanthoma. I am also interested in clinical- ...
Melanoma15
- Pathology of the skin in cutaneous melanoma. (nih.gov)
- Another type of skin cancer, melanoma , is more dangerous but less common. (medlineplus.gov)
- There was no obvious difference in the biodistribution of (I) and (IV) in relation to the site of the melanoma growth, i.e. eyes and skin. (curehunter.com)
- HCM-BROD-0221-C43 ( ATCC PDM-281 ) was isolated from metastatic melanoma of skin tissue. (atcc.org)
- Sylatron is a prescription medication used to prevent malignant melanoma (a kind of skin cancer ) from coming back after it has been removed by surgery. (rxwiki.com)
- Skin cancer, commonly classified as either melanoma or non-melanoma skin cancer (NMSC), is the most common type of cancer in Canada. (canada.ca)
- Footnote 1 The incidence of melanoma, the most fatal form of skin cancer, is increasing steadily-2.1% in males and 2.0% in females Footnote 1 , Footnote 2 every year between 1992 and 2013. (canada.ca)
- The risk of skin cancer due to indoor tanning is especially pronounced if first use occurs at an early age: there is a 59% higher risk of cutaneous melanoma among people who begin using indoor tanning devices before the age of 35 than among those who have never used tanning beds. (canada.ca)
- Footnote 3 The use of these devices before the age of 25 can also increase the risk of developing non-melanoma skin cancer, including basal cell carcinoma and squamous cell carcinoma. (canada.ca)
- The term non-melanoma skin cancer refers to all types of skin cancer apart from melanoma. (dermnetnz.org)
- A partial skin biopsy may be taken in cases of suspected non-melanoma skin cancer to confirm the diagnosis or determine a subtype which may influence treatment. (dermnetnz.org)
- The three most common malignant skin cancers are basal cell cancer, squamous cell cancer, and melanoma, each of which is named after the type of skin cell from which it arises. (medicalxpress.com)
- Melanoma survival rates are poorer than for non-melanoma skin cancer, although when melanoma is diagnosed at an early stage, treatment is easier and more people survive. (medicalxpress.com)
- Melanoma and non-melanoma skin cancers combined are more common than lung, breast, colorectal, and prostate cancer. (medicalxpress.com)
- Non-melanoma skin cancers are the most common skin cancers. (medicalxpress.com)
Cutaneous7
- The neoplastic cells in blastic plasmacytoid dendritic cell neoplasm (BPDCN) are typically positive for CD45, HLA-DR, CD43, CD4, CD56, and cutaneous lymphocyte-associated antigen (CLA). (medscape.com)
- We report nine cases of persistent/recurrent cutaneous CD30+ lymphoid neoplasms that demonstrated variable CD30 expression after treatment with brentuximab vedotin. (nih.gov)
- Next, co-exposure studies (combining topical HOCl and UV) performed in SKH-1 hairless mouse skin revealed that the HOCl-induced cutaneous stress response blocks redox and inflammatory gene expression elicited by subsequent acute UV exposure (Nos2, Ptgs2, Hmox1, Srxn1), a finding consistent with emerging clinical evidence in support of a therapeutic role of topical HOCl formulations for the suppression of inflammatory skin conditions (e.g. atopic dermatitis, psoriasis). (nih.gov)
- Intertrigo is caused by cutaneous inflammation of opposing skin surfaces. (aafp.org)
- Footnote 2 Exposure to ultraviolet (UV) radiation, including that from tanning equipment, has been demonstrated to increase the risk of skin cancer, including potentially fatal cutaneous and ocular melanomas. (canada.ca)
- Agranular CD4+/CD56+ hematodermic neoplasm is a distinct form of lymphoma with aggressive behavior and marked predilection for cutaneous involvement. (mcmaster.ca)
- Human papillomaviruses (HPVs) are etiologically associated with various benign and malignant neoplasms of cutaneous and mucosal epithelia. (mdpi.com)
Tumors7
- Tumors or cancer of the SKIN. (selfdecode.com)
- Following craniospinal irradiation in children with medulloblastoma, secondary neoplasms are among the most serious long-term sequelae that include leukemias and solid tumors of the urinary or digestive tracts, thyroid, skin, and central nervous system. (amjcaserep.com)
- Metachronous of development of 4 histopathologically different skin tumors following craniospinal irradiation for medulloblastoma in long-term survivors has not previously been reported. (amjcaserep.com)
- They are not true neoplasms ( tumors ), but they are invasive, spreading into nearby tissue. (ivis.org)
- 2017. Divergent roles of p120-catenin isoforms linked to altered cell viability, proliferation, and invasiveness in carcinogen-induced rat skin tumors. . (oregonstate.edu)
- The skin rash of mycosis fungoides may consist of patches, plaques, or tumors, which may have a long natural history. (medscape.com)
- For multiple neoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, codes for each site should be assigned. (icdcodelookup.com)
Malignant Skin Neoplasms1
- The development of malignant skin neoplasms in PLS patients is extremely rare. (karger.com)
Table of Neoplasms2
- See also, ICD-10 Table of Neoplasms . (icd10coded.com)
- The Table of Neoplasms should be used to identify the correct topography code. (icdcodelookup.com)
Benign Neoplasms1
- Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms . (lookformedical.com)
Plasmacytoid dend6
- Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a malignancy derived from plasmacyoid dendritic cells. (medscape.com)
- The precursors of plasmacytoid dendritic cells are the cells of origin for blastic plasmacytoid dendritic cell neoplasm (BPDCN), a clinically aggressive disease with a proclivity for the skin and leukemic involvement and for which no consensus currently exists regarding optimal treatment modalities. (medscape.com)
- Frequent sites of occurrence of blastic plasmacytoid dendritic cell neoplasm (BPDCN) include the skin, as well as the peripheral blood (PB) and bone marrow (BM). (medscape.com)
- A diffuse infiltrate of medium-sized cells with dispersed chromatin ("blastic") is characteristic of blastic plasmacytoid dendritic cell neoplasm (BPDCN). (medscape.com)
- Pathology of blastic plasmacytoid dendritic cell neoplasm (BPDCN).Skin involvement by blastic plasmacytoid dendritic cell neoplasm. (medscape.com)
- In the recent World Health Organization-European Organization for Research and Treatment of Cancer classification, the term blastic natural killer cell lymphoma has been replaced with CD4+/CD56+ hematodermic neoplasm because of its derivation from a plasmacytoid dendritic cell precursor. (mcmaster.ca)
Carcinoma2
- The development of aggressive squamous cell carcinoma (SCC) in areas of affected skin is a distinctive feature of the syndrome, occurring in approximately 15% of patients. (mcw.edu)
- Basal cell carcinoma (BCC) is a malignant epithelial neoplasm and is the most common cancer in the head and neck region. (who.int)
Lesions2
- A Congenital Nevocytic Nevus Registry has been established in the Oncology Section of the Skin and Cancer Unit at New York University Medical Center in the attempt to begin a long-term prospective study which might eventually provide some meaningful information concerning the natural history of such lesions, including the incidence of malignant melanomas. (nih.gov)
- Early in the course of mycosis fungoides, as well as in erythrodermic cases, the skin lesions may be nonspecific, with a nondiagnostic biopsy result, so that confusion with benign conditions is common (eg, eczema, neurodermatitis, pseudolymphoma syndrome). (medscape.com)
Squamous Cell1
- What's New in Basal and Squamous Cell Skin Cancer Research? (medlineplus.gov)
Cancer23
- Skin cancer is the most common form of cancer in the United States. (medlineplus.gov)
- If not treated, some types of skin cancer cells can spread to other tissues and organs. (medlineplus.gov)
- What Can I Do to Reduce My Risk of Skin Cancer? (medlineplus.gov)
- Our findings suggest that many children are at subsequent risk of skin cancer because of suboptimal sunscreen use, high rates of sunburning, and tanning bed use. (nih.gov)
- Nationally coordinated campaigns with strong policy components must be developed and sustained to prevent skin cancer in a new generation of children and adolescents. (nih.gov)
- Since this is not the first case of skin cancer in PLS patients, we are supporting the possibility that cathepsin-C play a role in cancer development. (karger.com)
- Legislative gaps should be addressed in order to better protect Canadians from this avoidable skin cancer risk. (canada.ca)
- Each subtype of skin cancer has unique characteristics. (dermnetnz.org)
- Many different types of less common skin cancer are listed in the related information section at the bottom of this page. (dermnetnz.org)
- Who gets skin cancer? (dermnetnz.org)
- Skin cancer most commonly affects older adults, but it can also affect younger adults, and rarely, children. (dermnetnz.org)
- Skin cancer tends to affect individuals with fair skin ( Fitzpatrick skin phototype I, II and III), although people with darker skin can also develop skin cancer. (dermnetnz.org)
- People who have had skin cancer have an increased risk of developing other skin cancers. (dermnetnz.org)
- A family history of skin cancer also increases risk. (dermnetnz.org)
- Certain genes such as melanocortin-1 receptor have been identified as carrying an increased risk of skin cancer. (dermnetnz.org)
- The common forms of skin cancer listed above are related to exposure to ultraviolet radiation (from sunlight or tanning beds ) and the effects of ageing. (dermnetnz.org)
- What are the clinical features of skin cancer? (dermnetnz.org)
- Skin cancer can usually be treated and cured before complications occur. (dermnetnz.org)
- How is skin cancer diagnosed? (dermnetnz.org)
- Clinicopathologic features, immunohistochemical features, and differential diagnosis of this rare neoplasm with emphasis on the recent World Health Organization-European Organization for Research and Treatment of Cancer classification are discussed. (mcmaster.ca)
- Skin neoplasms (also known as " skin cancer ") are skin growths with differing causes and varying degrees of malignancy. (medicalxpress.com)
- Skin cancer generally develops in the epidermis (the outermost layer of skin), so a tumor can usually be seen. (medicalxpress.com)
- Skin cancer is the most commonly diagnosed type of cancer. (medicalxpress.com)
Syndromes1
- Genetics of skin appendage neoplasms and related syndromes. (dermnetnz.org)
Acanthoma1
- An acanthoma is a skin neoplasm composed of squamous or epidermal cells. (wikipedia.org)
Tumour2
- The tumour is most common on those parts of the skin exposed to sunlight, which is thought to be a possible etiological factor [1]. (who.int)
- Brooke-Spiegler syndrome results in a predisposition to three types of benign skin appendage tumour. (dermnetnz.org)
Biopsy1
- Therefore skin biopsy is required to confirm the diagnosis. (dermnetnz.org)
Cancers5
- The keystone of the program is a technique known as Microscopically Controlled Excision (Mohs Technique, applied specifically for recurrent or other high-risk skin cancers. (yale.edu)
- Sophisticated approaches for the management of other complicated or rare skin cancers are also provided. (yale.edu)
- Skin cancers are malignant tumours in which there is an uncontrolled proliferation of any one of the many skin cell types, whereas the normal process of regeneration of skin involves replication of the cells in a controlled fashion. (dermnetnz.org)
- Skin cancers are generally diagnosed clinically by a dermatologist or family doctor, when learning of an enlarging, crusting , or bleeding lesion. (dermnetnz.org)
- This means that it is often possible to detect skin cancers at an early stage. (medicalxpress.com)
Melanocytic3
- Melanocytic Skin Neoplasms: What Lesson From Genomic Aberrations? (nih.gov)
- Studies on the genomic aberrations in melanocytic neoplasms have shown a complex genomic landscape. (nih.gov)
- In this context, the notion that melanocytic neoplasms can be classified as benign/malignant is hardly supportable, because all neoplasms harbor a certain number of mutations and the progression risk, that is, the malignant potential, is related and proportional to the burden of pathogenic mutations. (nih.gov)
Uncommon2
- Acquired digital fibrokeratoma (ADF), or acral fibrokeratoma, is an uncommon, benign neoplasm that presents as a solitary asymptomatic papule on the digit (finger or toe), nail bed, or periungual area of middle-aged adults. (logicalimages.com)
- DFSP is an uncommon neoplasm with low metastatic potential, carrying a 2%-5% risk of distant metastasis. (logicalimages.com)
Epidermis1
- Here, for the first time, we have profiled the HOCl-induced stress response in reconstructed human epidermis and SKH-1 hairless mouse skin. (nih.gov)
Tumor1
- Fifteen years later, she developed a primary adnexal tumor at the medial aspect of her left thigh, glomangioma at the skin of her upper abdomen, dermatofibrosarcoma protruberans at the skin of her upper back, and Kaposiform hemangioendothelioma of the upper abdomen. (amjcaserep.com)
Diagnosis2
- The median duration from the onset of skin symptoms to diagnosis is 6 years. (medscape.com)
- C63.7 is a valid billable ICD-10 diagnosis code for Malignant neoplasm of other specified male genital organs . (icd10coded.com)
Chronic1
- Intertrigo is often a chronic disorder that begins insidiously with the onset of pruritus, stinging, and a burning sensation in skin folds. (aafp.org)
Primary2
- Skin-testing with flea extracts is not as reliable as in the dog and the therapeutic response to a thorough flea-control of the animals and the environment is of primary importance. (vin.com)
- A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. (icdcodelookup.com)
Chapter2
- All neoplasms are classified in this chapter, whether they are functionally active or not. (icdcodelookup.com)
- An additional code from Chapter 4 may be used, to identify functional activity associated with any neoplasm. (icdcodelookup.com)
Tissue4
- We will obtain tissue (skin, blood, hair, buccal swabs) for laboratory examination of DNA repair and for genetic analysis. (nih.gov)
- Inability or unwillingness to provide tissue (skin, blood, buccal cells or hair) for laboratory studies. (nih.gov)
- 17,18 Therapy usually includes surgical resection, although with diffuse tissue involvement there may be an insufficient amount of normal skin to close the wound. (ivis.org)
- Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignant neoplasms are coded to pancreas, unspecified (C25.9). (icdcodelookup.com)
Symptoms2
- Immediately discontinue maraviroc and other suspected agents if signs or symptoms of severe skin or hypersensitivity reactions develop and monitor clinical status, including liver aminotransferases, closely. (nih.gov)
- Symptoms of thyroid changes include feeling cold or hot all the time, a change in your weight, and changes to your skin, trouble concentrating. (rxwiki.com)
Epidermal1
- BCC of the skin is generally believed to arise from the basal cell layer of the epithelium associated with epidermal adnexal structures. (who.int)
Arises1
- A non-metastasizing neoplasm that arises from the skin. (nih.gov)
Recurrent2
- This study seeks to assess for antigen loss in the setting of recurrent CD30+ neoplasms treated with brentuximab vedotin. (nih.gov)
- Skin barrier protectants, such as zinc oxide ointment and petrolatum, as part of a structured skin care routine that also includes gentle cleansing and moisturizing may reduce recurrent intertrigo infections. (aafp.org)
Organs1
- These are masses of foamy macrophages ( cells that are part of the immune system ), multinucleated giant cells ( fused epithelioid cells ), and cholesterol clefts that produce thickened, dimpled skin with yellow-to-orange coloration and occur infrequently in internal organs. (ivis.org)
20161
- [ 1 ] Within the 2016 World Health Organization (WHO) category of "acute myeloid leukemia and related neoplasms," the related neoplasms derive from immature cells with evidence of myeloid differentiation, or from precursors of plasmacytoid dendritic cells. (medscape.com)
Secondary1
- Excessive friction and inflammation can cause skin breakdown and create an entry point for secondary fungal and bacterial infections, such as Candida , group A beta-hemolytic streptococcus, and Corynebacterium minutissimum . (aafp.org)
Diseases1
- A handout on this topic is available at https://familydoctor.org/familydoctor/en/diseases-conditions/intertrigo.html . (aafp.org)
