Congenital defects of closure of one or more vertebral arches, which may be associated with malformations of the spinal cord, nerve roots, congenital fibrous bands, lipomas, and congenital cysts. These malformations range from mild (e.g., SPINA BIFIDA OCCULTA) to severe, including rachischisis where there is complete failure of neural tube and spinal cord fusion, resulting in exposure of the spinal cord at the surface. Spinal dysraphism includes all forms of spina bifida. The open form is called SPINA BIFIDA CYSTICA and the closed form is SPINA BIFIDA OCCULTA. (From Joynt, Clinical Neurology, 1992, Ch55, p34)
A common congenital midline defect of fusion of the vertebral arch without protrusion of the spinal cord or meninges. The lesion is also covered by skin. L5 and S1 are the most common vertebrae involved. The condition may be associated with an overlying area of hyperpigmented skin, a dermal sinus, or an abnormal patch of hair. The majority of individuals with this malformation are asymptomatic although there is an increased incidence of tethered cord syndrome and lumbar SPONDYLOSIS. (From Joynt, Clinical Neurology, 1992, Ch55, p34)
A form of spinal dysraphism associated with a protruding cyst made up of either meninges (i.e., a MENINGOCELE) or meninges in combination with spinal cord tissue (i.e., a MENINGOMYELOCELE). These lesions are frequently associated with spinal cord dysfunction, HYDROCEPHALUS, and SYRINGOMYELIA. (From Davis et al., Textbook of Neuropathology, 2nd ed, pp224-5)
A malformation of the nervous system caused by failure of the anterior neuropore to close. Infants are born with intact spinal cords, cerebellums, and brainstems, but lack formation of neural structures above this level. The skull is only partially formed but the eyes are usually normal. This condition may be associated with folate deficiency. Affected infants are only capable of primitive (brain stem) reflexes and usually do not survive for more than two weeks. (From Menkes, Textbook of Child Neurology, 5th ed, p247)
A fibrous degeneration, cyst formation, and the presence of fibrous nodules in bone, usually due to HYPERPARATHYROIDISM.
Excessive accumulation of cerebrospinal fluid within the cranium which may be associated with dilation of cerebral ventricles, INTRACRANIAL HYPERTENSION; HEADACHE; lethargy; URINARY INCONTINENCE; and ATAXIA.
Congenital, or rarely acquired, herniation of meningeal and spinal cord tissue through a bony defect in the vertebral column. The majority of these defects occur in the lumbosacral region. Clinical features include PARAPLEGIA, loss of sensation in the lower body, and incontinence. This condition may be associated with the ARNOLD-CHIARI MALFORMATION and HYDROCEPHALUS. (From Joynt, Clinical Neurology, 1992, Ch55, pp35-6)
Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy generally occurring between days 18-29 of gestation. Ectodermal and mesodermal malformations (mainly involving the skull and vertebrae) may occur as a result of defects of neural tube closure. (From Joynt, Clinical Neurology, 1992, Ch55, pp31-41)
An irregularly shaped cavity in the RHOMBENCEPHALON, located between the MEDULLA OBLONGATA; the PONS; and the isthmus in front, and the CEREBELLUM behind. It is continuous with the central canal of the cord below and with the CEREBRAL AQUEDUCT above, and through its lateral and median apertures it communicates with the SUBARACHNOID SPACE.
Any fluid-filled closed cavity or sac that is lined by an EPITHELIUM. Cysts can be of normal, abnormal, non-neoplastic, or neoplastic tissues.
Brain tissue herniation through a congenital or acquired defect in the skull. The majority of congenital encephaloceles occur in the occipital or frontal regions. Clinical features include a protuberant mass that may be pulsatile. The quantity and location of protruding neural tissue determines the type and degree of neurologic deficit. Visual defects, psychomotor developmental delay, and persistent motor deficits frequently occur.
Inflammation of the GASTRIC MUCOSA, a lesion observed in a number of unrelated disorders.
Tubes inserted to create communication between a cerebral ventricle and the internal jugular vein. Their emplacement permits draining of cerebrospinal fluid for relief of hydrocephalus or other condition leading to fluid accumulation in the ventricles.
A process of differentiation having for its goal the development of the individual personality.
Dysfunction of the URINARY BLADDER due to disease of the central or peripheral nervous system pathways involved in the control of URINATION. This is often associated with SPINAL CORD DISEASES, but may also be caused by BRAIN DISEASES or PERIPHERAL NERVE DISEASES.
A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses (POACEAE). Folic acid is used in the treatment and prevention of folate deficiencies and megaloblastic anemia.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
Marked developmental anomalies of a fetus or infant.
An FAD-dependent oxidoreductase found primarily in BACTERIA. It is specific for the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate. This enzyme was formerly listed as EC 1.1.1.68 and 1.1.99.15.
Abortion induced to save the life or health of a pregnant woman. (From Dorland, 28th ed)
Autosomal recessive syndrome characterized by hypogenesis or agenesis of CORPUS CALLOSUM. Clinical features include MENTAL RETARDATION; CRANIOFACIAL ABNORMALITIES; digital malformations, and growth retardation.
An infant during the first month after birth.
Malformations of organs or body parts during development in utero.
A tube of ectodermal tissue in an embryo that will give rise to the CENTRAL NERVOUS SYSTEM, including the SPINAL CORD and the BRAIN. Lumen within the neural tube is called neural canal which gives rise to the central canal of the spinal cord and the ventricles of the brain. For malformation of the neural tube, see NEURAL TUBE DEFECTS.
Determination of the nature of a pathological condition or disease in the postimplantation EMBRYO; FETUS; or pregnant female before birth.
In utero measurement corresponding to the sitting height (crown to rump) of the fetus. Length is considered a more accurate criterion of the age of the fetus than is the weight. The average crown-rump length of the fetus at term is 36 cm. (From Williams Obstetrics, 18th ed, p91)
A group of congenital malformations involving the brainstem, cerebellum, upper spinal cord, and surrounding bony structures. Type II is the most common, and features compression of the medulla and cerebellar tonsils into the upper cervical spinal canal and an associated MENINGOMYELOCELE. Type I features similar, but less severe malformations and is without an associated meningomyelocele. Type III has the features of type II with an additional herniation of the entire cerebellum through the bony defect involving the foramen magnum, forming an ENCEPHALOCELE. Type IV is a form a cerebellar hypoplasia. Clinical manifestations of types I-III include TORTICOLLIS; opisthotonus; HEADACHE; VERTIGO; VOCAL CORD PARALYSIS; APNEA; NYSTAGMUS, CONGENITAL; swallowing difficulties; and ATAXIA. (From Menkes, Textbook of Child Neurology, 5th ed, p261; Davis, Textbook of Neuropathology, 2nd ed, pp236-46)

Neural tube defects along the Texas-Mexico border, 1993-1995. (1/26)

In response to a 1991 anencephaly cluster in Cameron County, Texas, a surveillance and neural tube defect (NTD) recurrence prevention project for NTDs was implemented in the 14 Texas-Mexico border counties. For 1993-1995, NTD-affected pregnancies were identified at all gestational ages through active surveillance of multiple case-ascertainment sources. There were 87 cases of anencephaly, 96 cases of spina bifida, and 14 cases of encephalocele for respective rates of 6.4, 7.1, and 1.1 per 10,000 live births. Of the 197 NTD case-women, 93% were Hispanic. The overall, Hispanic, and Anglo NTD rates were, respectively, 14.6, 14.9, and 10.6 per 10,000 live births. The NTD rate for El Paso County (9.8 per 10,000), the most northwestern Texas county, was significantly lower (p = 0.001) than the aggregate rate for the rest of the Texas border (17.1 per 10,000). The overall Texas border rate was significantly higher (p < 0.001) than a recently estimated rate of 9.3 for California and minimally higher than a recently adjusted rate of 11.3 for the Metropolitan Atlanta Congenital Defects Program counties (p = 0.052), both of which now reflect all gestational ages. Of the 197 Texas border cases, 85% (168 cases) reached a gestational age of > or =20 weeks. Excluding cases of <20 weeks' gestation in the rate had a more marked effect on reducing the anencephaly rate (4.9 per 10,000) than the spina bifida rate (6.7 per 10,000). A country of birth was known for 153 (83%) of the 184 Hispanic case-women: 63% were born in Mexico; 24%, in Texas; and 11%, elsewhere in the United States. Rates for Mexico-born Hispanic women (15.1 per 10,000) were significantly higher than rates for United States-born Hispanic women (9.5 per 10,000) (p = 0.006).  (+info)

Teratogenic response to arsenite during neurulation: relative sensitivities of C57BL/6J and SWV/Fnn mice and impact of the splotch allele. (2/26)

Arsenic is an environmental contaminant that induces congenital malformations, primarily neural tube defects, in laboratory animals, and it may contribute to human birth defects. The acute doses of arsenicals required to elicit teratogenesis in outbred strains of mice, however, are orders of magnitude higher than those to which humans are exposed environmentally. In order to examine interactions between arsenite administration during neurulation and murine genotype, the present study compares two inbred mouse strains, establishes a teratogenic dose of arsenite, and evaluates the effect of the splotch mutation on arsenic-induced teratogenesis. SWV/Fnn or C57BL/6J females were injected intraperitoneally with sodium arsenite (10 mg/kg) on days 6.5, 7.0, 7.5, 8.0, 8.5, or 9.0 of gestation. A dose-response study was carried out in the C57BL/6J strain, and the effect of the splotch mutation, introduced via the male (C57BL/6J Sp/+), was assessed. Fetuses were examined for external, visceral, and skeletal malformations. Fetuses from crosses of C57BL/6J females with C57BL/6J Sp/+ males were genotyped by PCR. Ten-mg/kg sodium arsenite was teratogenic in nearly 50% of C57BL/6J fetuses, and the C57BL/6J strain was significantly more sensitive to arsenite-induced embryo-lethality and teratogenicity than the SWV/Fnn strain. The spectrum of malformations produced was dependent on the gestational time point of arsenite administration. Introduction of the splotch allele significantly increased neural tube defects and other specific malformations. This result demonstrates that a mutation in a single gene can increase sensitivity to arsenic-induced birth defects. This murine study examines the interaction between arsenite-induced teratogenicity and genotype.  (+info)

Prevalence of aneuploidy and additional anatomic abnormalities in fetuses with open spina bifida: population based study in Utah. (3/26)

Data were used to determine the population prevalence of aneuploidy and additional anatomic abnormalities in fetuses with open spina bifida. The ability of sonography to predict aneuploidy and identify additional anatomic abnormalities in euploid fetuses was assessed. All cases of spina bifida occurring in the state of Utah from 1995 through 1997 were reviewed using Utah Birth Defect Network data, including stillborn, liveborn, and terminated cases. Chromosomes were known in 45 of 51 cases of open spina bifida. Of the 45 fetuses, 6 (13%) were aneuploid. Major anatomic abnormalities were present in four of six (67%) cases, and two of six (33%) cases had additional anomalies that could be missed sonographically. Of 39 euploid fetuses, 12 (31%) had additional abnormalities, but only half likely would be detected sonographically. Our 4% risk of aneuploidy in sonographically isolated spina bifida is substantially higher than the risk associated with advanced maternal age (0.37%).  (+info)

Audit of prenatal and postnatal diagnosis of isolated open spina bifida in three university hospitals in The Netherlands. (4/26)

OBJECTIVE: To audit the current Dutch policy of prenatal detection of isolated open spina bifida based on offering detailed ultrasound examination only on indication. METHODS: A retrospective analysis of prenatally diagnosed isolated spina bifida cases and of newborns diagnosed with this condition was carried out in three university hospitals. The data were collected from databases and clinical records of the departments of prenatal diagnosis, obstetrics, neonatology, child neurology and neurosurgery of the three centers. RESULTS: Between January 1996 and December 1999, 88 cases of isolated open spina bifida were diagnosed prenatally by ultrasound investigation. Thirty-eight cases (43%) were diagnosed before the 24th week of gestation. Of these, 35 (92%) ended in termination of the pregnancy at the parents' request. Of the remaining 50 cases (57%) diagnosed after the 24th week of gestation, eight (16%) pregnancies were terminated beyond the legal limit for termination due to the severity of the condition. Of the 88 cases of isolated spina bifida, 25 infants (28%) were still alive at the age of 4 years. In the same audit period 112 newborn infants with isolated open spina bifida were admitted to the neonatology, child neurology, or neurosurgery ward of the three centers. Of these cases, 47 (42%) had been diagnosed prenatally and 65 (58%) were an unexpected finding at birth. In 24 infants (21%) surgical treatment was withheld because of the severity of the condition and predicted poor outcome, whereas the remaining 88 infants (79%) underwent surgical repair. CONCLUSION: The current practice in The Netherlands of offering ultrasound screening to high-risk patients only leads to the early detection of a minority of cases of spina bifida. Most cases are diagnosed either after the 24th week of gestation or they remain undiagnosed until after birth. When spina bifida is diagnosed before the 24th week of gestation the vast majority of parents opt for termination. In order to reduce the birth prevalence of spina bifida in The Netherlands the introduction of a policy of routine ultrasound screening should be considered.  (+info)

Long-term outcome in open spina bifida. (5/26)

BACKGROUND: Doctors need reliable data on outcome in order to help parents faced with difficult decisions about termination of an affected pregnancy or treatment after birth. AIM: To determine survival, health and lifestyle at the mean age of 30 years in a complete cohort of adults born with open spina bifida. DESIGN OF STUDY: Prospective cohort study. PARTICIPANTS: Well-documented cohort of 117 consecutive cases of open spina bifida whose backs were closed non-selectively at birth between 1963 and 1971. METHOD: Survivors (age range = 26 to 33 years) were surveyed by postal questionnaire and telephone interview. The main outcome measures were the health, independence and lifestyle of the survivors in terms of living in the community, driving a car and working in open employment. RESULTS: Ascertainment was 100%. Sixty (51%) had died, mainly the most disabled. Of the 57 survivors, 84% had a cerebrospinal fluid (CSF) shunt, 70% had an IQ of 80 or more, 37% lived independently in the community, 39% drove a car, 30% could walk more than 50 metres and 26% were in open employment. However one-third (19) still needed daily care, three were on respiratory support, two were blind, two had diabetes mellitus, and one was on dialysis. Mortality, disability and achievement reflected the neurological deficit that had been recorded in infancy in terms of sensory level. Attainment and independence were reduced in those who had needed revision of CSF shunt. CONCLUSION: The survivors in this unselected cohort showed a wide range of outcome from apparent normality to very severe disability. This reflected both the extent of their original neurological deficit and events in the history of their CSF shunt.  (+info)

Perineal sensation: an important predictor of long-term outcome in open spina bifida. (6/26)

OBJECTIVES: To see if perineal sensation in infants with open spina bifida is associated with a better long-term outcome, particularly in terms of survival, renal-related deaths and incontinence. METHODS: We conducted a prospective cohort study on a complete cohort of 117 consecutive patients with open spina bifida, whose backs were closed non-selectively at birth between 1963 and 1971. A meticulous neurological examination in infancy showed that 33 (28%) of them had perineal sensation, defined as intact sensation to pinprick in at least one dermatome on one side in the saddle area (S2-4). Data recorded within 48 h of birth and during six reviews between 1972 and 2002 were used. Details of deaths were obtained from medical records and from the Office of National Statistics. RESULTS: By December 2005, 57% (67/117) of the cohort had died. There were 50 survivors with a mean age 38 years (range 35-41). More of those with perineal sensation survived than those without (23/33 v 27/84, p<0.001). This difference was mainly caused by 19 renal deaths in those lacking perineal sensation. Crucially there were no renal-related deaths in those with perineal sensation (0/33 v 19/84, p = 0.003). Among the survivors, those with perineal sensation were more likely than the remainder to be continent of urine and faeces (10/23 v 1/27, p<0.001 and 18/23 v 9/27, p = 0.002 respectively). They were also more likely to be able to walk at least 50 m (11/23 v 5/27, p = 0.027) and never to have had pressure sores (15/23 v 9/27, p = 0.025). CONCLUSIONS: A simple assessment of perineal sensation in infancy predicts long-term outcome in terms of survival, renal prognosis and incontinence in open spina bifida.  (+info)

Potential association between infertility and spinal neural tube defects in offspring. (7/26)

BACKGROUND: We examined the possible association between infertility and spinal neural tube defects (NTDs). METHODS: This is a nested case-control study within the Kaiser Permanente Medical Care Program (KPMCP) in Northern California. Among a birth cohort of 110,624 singleton infants > or = 36 weeks gestation, 1994-1997, we electronically identified cases of spinal NTDs and confirmed the diagnosis by chart review. Controls (n = 1,608) were randomly selected from the birth population. History of infertility was defined as: (1) physician diagnosis of infertility; (2) prescription for an infertility medication noted in the KPMCP pharmacy; and/or (3) evaluation at 1 of 15 infertility clinics in Northern California. RESULTS: Eighteen infants diagnosed with spinal NTDs (prevalence 1.6/10,000) included 13 with spina bifida cystica and 5 with spina bifida occulta. Case mothers were more likely to have a history of infertility (4/18 vs. 96/1,608, OR 4.3, 95% CI 1.01-14.0), and to have been prescribed clomiphene citrate within the window spanning 60 days before to 15 days after conception (3/18 vs. 32/1,608, OR 11.7, 95% CI 2.0-44.8). CONCLUSION: This exploratory study suggests that infertility may be associated with an increased risk of spinal NTDs among liveborn, term infants.  (+info)

Why IQ is not a covariate in cognitive studies of neurodevelopmental disorders. (8/26)

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Spinal dysraphism is a broad term used to describe a group of congenital malformations of the spine and spinal cord. These defects occur during embryonic development when the neural tube, which eventually forms the brain and spinal cord, fails to close properly. This results in an incomplete development or formation of the spinal cord and/or vertebral column.

There are two main categories of spinal dysraphism: open (also called exposed or overt) and closed (also called hidden or occult). Open spinal dysraphisms, such as myelomeningocele and myelocele, involve exposure of the spinal cord and/or its coverings through an opening in the back. Closed spinal dysraphisms, such as lipomyelomeningocele, tethered cord syndrome, and diastematomyelia, are more subtle and may not be visibly apparent at birth.

Symptoms of spinal dysraphism can vary widely depending on the type and severity of the defect. They may include motor and sensory impairments, bowel and bladder dysfunction, orthopedic deformities, and increased risk for neurological complications such as hydrocephalus (accumulation of fluid in the brain). Early diagnosis and intervention are crucial to optimize outcomes and minimize potential complications.

Spina Bifida Occulta is a type of spinal dysraphism, which is a birth defect involving incomplete closure of the spine. In Spina Bifida Occulta, the spinal bones (vertebrae) do not fully form and close around the spinal cord during fetal development, leaving a small gap or split in the lower back region. However, the spinal cord and nerves usually develop normally and are not exposed or damaged, unlike in more severe forms of spina bifida.

In many cases, individuals with Spina Bifida Occulta do not experience any symptoms and may not even know they have the condition unless it is discovered during an imaging test for another reason. In some instances, people with this condition might develop late-onset neurological symptoms or complications such as back pain, muscle weakness, or changes in bladder or bowel function.

It's essential to note that while Spina Bifida Occulta is generally less severe than other forms of spina bifida, it can still pose risks and may require medical evaluation and monitoring to ensure proper development and address any potential issues.

Spina Bifida Cystica is a type of neural tube defect that occurs when the bones of the spine (vertebrae) do not form properly around the developing spinal cord, resulting in a sac-like protrusion of the spinal cord and its surrounding membranes through an opening in the spine. This sac, called a meningocele or myelomeningocele, can be covered with skin or exposed, and it may contain cerebrospinal fluid, nerve roots, or portions of the spinal cord.

Myelomeningocele is the most severe form of Spina Bifida Cystica, where the sac contains a portion of the spinal cord and nerves. This can lead to various neurological complications such as weakness or paralysis below the level of the spine affected, loss of sensation, bladder and bowel dysfunction, and hydrocephalus (accumulation of cerebrospinal fluid in the brain). Early diagnosis and intervention, including prenatal surgery, can help improve outcomes for individuals with Spina Bifida Cystica.

Anencephaly is a serious birth defect that affects the neural tube, which is the structure that develops into the brain and spinal cord. In anencephaly, the neural tube fails to close properly during fetal development, resulting in the absence of a major portion of the brain, skull, and scalp.

Anencephaly is typically diagnosed through prenatal ultrasound or other imaging tests. Unfortunately, it is a fatal condition, and most babies with anencephaly do not survive birth or live for more than a few hours or days after birth.

The exact cause of anencephaly is not fully understood, but it is believed to be related to genetic factors as well as environmental influences such as folic acid deficiency and exposure to certain medications or chemicals during pregnancy. Pregnant women are often advised to take folic acid supplements to reduce the risk of neural tube defects, including anencephaly.

Osteitis fibrosa cystica is a medical condition that refers to the abnormal bone remodeling process characterized by increased bone resorption and formation, leading to bone thickening and weakening. It is also known as "von Recklinghausen's disease of bone" or "monostotic fibrous dysplasia."

This condition is typically caused by excessive production of parathyroid hormone (PTH) due to a benign or malignant tumor of the parathyroid gland, known as hyperparathyroidism. The overproduction of PTH leads to an imbalance in calcium and phosphorus metabolism, resulting in increased bone resorption and fibrous tissue deposition within the bone marrow.

The clinical features of osteitis fibrosa cystica include bone pain, fractures, bone deformities, and elevated levels of calcium and alkaline phosphatase in the blood. Radiographic findings may show characteristic "rugger jersey" or "salt and pepper" patterns of alternating areas of increased and decreased bone density.

Treatment typically involves surgical removal of the abnormal parathyroid gland tissue, followed by medical management to prevent further bone loss and promote healing.

Hydrocephalus is a medical condition characterized by an abnormal accumulation of cerebrospinal fluid (CSF) within the brain, leading to an increase in intracranial pressure and potentially causing damage to the brain tissues. This excessive buildup of CSF can result from either overproduction or impaired absorption of the fluid, which typically causes the ventricles (fluid-filled spaces) inside the brain to expand and put pressure on surrounding brain structures.

The condition can be congenital, present at birth due to genetic factors or abnormalities during fetal development, or acquired later in life as a result of injuries, infections, tumors, or other disorders affecting the brain's ability to regulate CSF flow and absorption. Symptoms may vary depending on age, severity, and duration but often include headaches, vomiting, balance problems, vision issues, cognitive impairment, and changes in behavior or personality.

Treatment for hydrocephalus typically involves surgically implanting a shunt system that diverts the excess CSF from the brain to another part of the body where it can be absorbed, such as the abdominal cavity. In some cases, endoscopic third ventriculostomy (ETV) might be an alternative treatment option, creating a new pathway for CSF flow within the brain. Regular follow-ups with neurosurgeons and other healthcare professionals are essential to monitor the condition and make any necessary adjustments to the treatment plan.

Meningomyelocele is a type of neural tube defect that affects the development of the spinal cord and the surrounding membranes known as meninges. In this condition, a portion of the spinal cord and meninges protrude through an opening in the spine, creating a sac-like structure on the back. This sac is usually covered by skin, but it may be open in some cases.

Meningomyelocele can result in various neurological deficits, including muscle weakness, paralysis, and loss of sensation below the level of the lesion. It can also cause bladder and bowel dysfunction, as well as problems with sexual function. The severity of these symptoms depends on the location and extent of the spinal cord defect.

Early diagnosis and treatment are crucial for managing meningomyelocele and preventing further complications. Treatment typically involves surgical closure of the opening in the spine to protect the spinal cord and prevent infection. Physical therapy, occupational therapy, and other supportive care measures may also be necessary to help individuals with meningomyelocele achieve their full potential for mobility and independence.

Neural Tube Defects (NTDs) are a group of birth defects that affect the brain, spine, or spinal cord. They occur when the neural tube, which forms the early brain and spinal cord of the embryo, does not close properly during fetal development. This can result in various conditions such as:

1. Anencephaly: a severe defect where most of the brain and skull are missing. Infants with anencephaly are usually stillborn or die shortly after birth.
2. Spina bifida: a condition where the spine does not close properly, leaving a portion of the spinal cord and nerves exposed. This can result in various neurological problems, including paralysis, bladder and bowel dysfunction, and hydrocephalus (fluid buildup in the brain).
3. Encephalocele: a condition where the skull does not close properly, allowing the brain to protrude through an opening in the skull. This can result in various neurological problems, including developmental delays, vision and hearing impairments, and seizures.

NTDs are thought to be caused by a combination of genetic and environmental factors, such as folic acid deficiency, obesity, diabetes, and exposure to certain medications during pregnancy. Folic acid supplementation before and during early pregnancy has been shown to reduce the risk of NTDs.

The fourth ventricle is a part of the cerebrospinal fluid-filled system in the brain, located in the posterior cranial fossa and continuous with the central canal of the medulla oblongata and the cerebral aqueduct. It is shaped like a cavity with a roof, floor, and lateral walls, and it communicates rostrally with the third ventricle through the cerebral aqueduct and caudally with the subarachnoid space through the median and lateral apertures (foramina of Luschka and Magendie). The fourth ventricle contains choroid plexus tissue, which produces cerebrospinal fluid. Its roof is formed by the cerebellar vermis and the superior medullary velum, while its floor is composed of the rhomboid fossa, which includes several important structures such as the vagal trigone, hypoglossal trigone, and striae medullares.

A cyst is a closed sac, having a distinct membrane and division between the sac and its surrounding tissue, that contains fluid, air, or semisolid material. Cysts can occur in various parts of the body, including the skin, internal organs, and bones. They can be caused by various factors, such as infection, genetic predisposition, or blockage of a duct or gland. Some cysts may cause symptoms, such as pain or discomfort, while others may not cause any symptoms at all. Treatment for cysts depends on the type and location of the cyst, as well as whether it is causing any problems. Some cysts may go away on their own, while others may need to be drained or removed through a surgical procedure.

An Encephalocele is a type of neural tube defect that occurs when the bones of the skull do not close completely during fetal development. This results in a sac-like protrusion of the brain and the membranes that cover it through an opening in the skull. The sac may be visible on the scalp, forehead, or back of the head, and can vary in size. Encephaloceles can cause a range of symptoms, including developmental delays, intellectual disabilities, vision problems, and seizures, depending on the severity and location of the defect. Treatment typically involves surgical repair of the encephalocele soon after birth to prevent further damage to the brain and improve outcomes.

Gastritis is a medical condition characterized by inflammation of the lining of the stomach. It can be caused by various factors, including bacterial infections (such as Helicobacter pylori), regular use of nonsteroidal anti-inflammatory drugs (NSAIDs), excessive alcohol consumption, and stress.

Gastritis can present with a range of symptoms, such as abdominal pain or discomfort, nausea, vomiting, loss of appetite, and bloating. In some cases, gastritis may not cause any noticeable symptoms. Depending on the severity and duration of inflammation, gastritis can lead to complications like stomach ulcers or even stomach cancer if left untreated.

There are two main types of gastritis: acute and chronic. Acute gastritis develops suddenly and may last for a short period, while chronic gastritis persists over time, often leading to atrophy of the stomach lining. Diagnosis typically involves endoscopy and tissue biopsy to assess the extent of inflammation and rule out other potential causes of symptoms. Treatment options depend on the underlying cause but may include antibiotics, proton pump inhibitors, or lifestyle modifications.

Cerebrospinal fluid (CSF) shunts are medical devices used to divert the flow of excess CSF from the brain and spinal cord to another part of the body, usually the abdominal cavity. The shunt consists of a catheter, a valve, and a reservoir.

The catheter is inserted into one of the ventricles in the brain or the subarachnoid space surrounding the spinal cord to drain the excess CSF. The valve regulates the flow of CSF to prevent over-drainage, which can cause complications such as low CSF pressure and brain sagging. The reservoir is a small chamber that allows for easy access to the shunt system for monitoring and adjusting the pressure settings.

CSF shunts are typically used to treat conditions associated with increased production or impaired absorption of CSF, such as hydrocephalus, communicating hydrocephalus, normal pressure hydrocephalus, and pseudotumor cerebri. By reducing the buildup of CSF in the brain, shunts can help alleviate symptoms such as headaches, nausea, vomiting, vision problems, and cognitive impairment.

It is important to note that while CSF shunts are effective in managing these conditions, they also carry risks of complications such as infection, obstruction, malfunction, and over-drainage. Regular monitoring and follow-up care are necessary to ensure proper functioning and minimize the risk of complications.

In the context of psychology and psychiatry, "individuation" is a term that was developed by Carl Jung to describe the process of psychological differentiation and integration that an individual undergoes in order to become a unique and whole person. It involves the development of a distinct identity and sense of self, separate from the collective or societal expectations and pressures.

However, I should clarify that "individuation" is not a term commonly used in medical terminology, but rather a concept from depth psychology. Therefore, it may not have a specific medical definition as such.

Neurogenic bladder is a term used to describe bladder dysfunction due to neurological damage or disease. The condition can result in problems with bladder storage and emptying, leading to symptoms such as urinary frequency, urgency, hesitancy, incontinence, and retention.

Neurogenic bladder can occur due to various medical conditions, including spinal cord injury, multiple sclerosis, Parkinson's disease, diabetic neuropathy, and stroke. The damage to the nerves that control bladder function can result in overactivity or underactivity of the bladder muscle, leading to urinary symptoms.

Management of neurogenic bladder typically involves a multidisciplinary approach, including medications, bladder training, catheterization, and surgery in some cases. The specific treatment plan depends on the underlying cause of the condition and the severity of the symptoms.

Folic acid is the synthetic form of folate, a type of B vitamin (B9). It is widely used in dietary supplements and fortified foods because it is more stable and has a longer shelf life than folate. Folate is essential for normal cell growth and metabolism, and it plays a critical role in the formation of DNA and RNA, the body's genetic material. Folic acid is also crucial during early pregnancy to prevent birth defects of the brain and spine called neural tube defects.

Medical Definition: "Folic acid is the synthetic form of folate (vitamin B9), a water-soluble vitamin involved in DNA synthesis, repair, and methylation. It is used in dietary supplementation and food fortification due to its stability and longer shelf life compared to folate. Folic acid is critical for normal cell growth, development, and red blood cell production."

Pregnancy is a physiological state or condition where a fertilized egg (zygote) successfully implants and grows in the uterus of a woman, leading to the development of an embryo and finally a fetus. This process typically spans approximately 40 weeks, divided into three trimesters, and culminates in childbirth. Throughout this period, numerous hormonal and physical changes occur to support the growing offspring, including uterine enlargement, breast development, and various maternal adaptations to ensure the fetus's optimal growth and well-being.

I could not find a medical definition for "Severe Teratoid Abnormalities" as it is not a widely recognized or established medical term. However, the term "teratoid" is used in medical contexts to describe abnormal growths or tumors that contain a mixture of tissue types, such as skin, muscle, bone, and nerve cells. A severe teratoid abnormality would likely refer to a particularly serious or extreme case of such a condition.

If you are looking for information on a specific medical condition or issue, I would be happy to help you try to find more accurate and relevant information. Can you please provide me with more context or details?

A therapeutic abortion is the deliberate termination of a pregnancy before viability (the ability of the fetus to survive outside the womb), which is generally considered to be around 24 weeks of gestation. The term "therapeutic" is used to describe abortions that are performed for medical reasons, such as to protect the life or health of the pregnant individual, or in cases where the fetus has a severe abnormality and cannot survive outside the womb.

Therapeutic abortions may be recommended in situations where continuing the pregnancy poses a significant risk to the health or life of the pregnant individual. For example, if a pregnant person has a serious medical condition such as heart disease, cancer, or severe pre-eclampsia, continuing the pregnancy could worsen their condition and put them at risk of serious complications or even death. In these cases, a therapeutic abortion may be necessary to protect the health or life of the pregnant individual.

Therapeutic abortions may also be recommended in cases where the fetus has a severe abnormality that is not compatible with life outside the womb. For example, if the fetus has a condition such as anencephaly (a neural tube defect where the brain and skull do not form properly), or a chromosomal abnormality such as Trisomy 13 or 18, continuing the pregnancy may result in a stillbirth or a short, painful life for the infant after birth. In these cases, a therapeutic abortion may be considered a compassionate option to prevent unnecessary suffering.

It's important to note that the decision to undergo a therapeutic abortion is a deeply personal one, and should be made in consultation with medical professionals and trusted family members or support networks. Ultimately, the decision should be based on what is best for the physical and emotional health of the pregnant individual, taking into account their values, beliefs, and circumstances.

Acrocallosal syndrome is a rare genetic disorder characterized by the underdevelopment or absence of the corpus callosum (the part of the brain that connects the two hemispheres) and abnormalities of the fingers, toes, and face. The symptoms of this condition can vary widely in severity, but may include intellectual disability, developmental delays, seizures, weak muscle tone, abnormalities of the skull and facial bones, widely spaced eyes, a flat nasal bridge, a short nose with upturned nostrils, an open mouth with a highly arched roof, and a small jaw. In addition, individuals with Acrocallosal syndrome often have extra fingers or toes (polydactyly) and other skeletal abnormalities.

Acrocallosal syndrome is caused by mutations in the KIF7 gene, which provides instructions for making a protein that helps regulate the development and organization of cells in the body. Mutations in this gene are thought to disrupt the normal functioning of this protein, leading to the characteristic signs and symptoms of Acrocallosal syndrome. The disorder is inherited in an autosomal recessive manner, which means that an individual must inherit two copies of the mutated gene (one from each parent) in order to be affected.

A newborn infant is a baby who is within the first 28 days of life. This period is also referred to as the neonatal period. Newborns require specialized care and attention due to their immature bodily systems and increased vulnerability to various health issues. They are closely monitored for signs of well-being, growth, and development during this critical time.

Congenital abnormalities, also known as birth defects, are structural or functional anomalies that are present at birth. These abnormalities can develop at any point during fetal development, and they can affect any part of the body. They can be caused by genetic factors, environmental influences, or a combination of both.

Congenital abnormalities can range from mild to severe and may include structural defects such as heart defects, neural tube defects, and cleft lip and palate, as well as functional defects such as intellectual disabilities and sensory impairments. Some congenital abnormalities may be visible at birth, while others may not become apparent until later in life.

In some cases, congenital abnormalities may be detected through prenatal testing, such as ultrasound or amniocentesis. In other cases, they may not be diagnosed until after the baby is born. Treatment for congenital abnormalities varies depending on the type and severity of the defect, and may include surgery, therapy, medication, or a combination of these approaches.

The Neural Tube is a structure that forms during the development of an embryo and eventually becomes the brain, spinal cord, and other parts of the nervous system. It is a narrow channel that runs along the back of the embryo, forming from the ectoderm (one of the three germ layers) and closing around the 23rd or 26th day after conception. Defects in the closure of the neural tube can lead to conditions such as spina bifida and anencephaly.

Prenatal diagnosis is the medical testing of fetuses, embryos, or pregnant women to detect the presence or absence of certain genetic disorders or birth defects. These tests can be performed through various methods such as chorionic villus sampling (CVS), amniocentesis, or ultrasound. The goal of prenatal diagnosis is to provide early information about the health of the fetus so that parents and healthcare providers can make informed decisions about pregnancy management and newborn care. It allows for early intervention, treatment, or planning for the child's needs after birth.

Crown-rump length (CRL) is a medical measurement used in obstetrics to estimate the age of a developing fetus. It refers to the length from the top of the head (crown) to the bottom of the buttocks (rump). This measurement is typically taken during an ultrasound examination in the first trimester of pregnancy, between 8 and 13 weeks of gestation.

The CRL is used to calculate the estimated due date and to monitor fetal growth and development. It can also help identify potential issues or abnormalities in fetal development. As the pregnancy progresses, other measurements such as head circumference, abdominal circumference, and femur length are used to assess fetal growth and development.

Arnold-Chiari malformation is a structural abnormality of the brain and skull base, specifically the cerebellum and brainstem. It is characterized by the descent of the cerebellar tonsils and sometimes parts of the brainstem through the foramen magnum (the opening at the base of the skull) into the upper spinal canal. This can cause pressure on the brainstem and cerebellum, potentially leading to a range of symptoms such as headaches, neck pain, unsteady gait, swallowing difficulties, hearing or balance problems, and in severe cases, neurological deficits. There are four types of Arnold-Chiari malformations, with type I being the most common and least severe form. Types II, III, and IV are progressively more severe and involve varying degrees of hindbrain herniation and associated neural tissue damage. Surgical intervention is often required to alleviate symptoms and prevent further neurological deterioration.

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