Spinal Cord Diseases
Spinal Cord
Wasting of the small hand muscles in upper and mid-cervical cord lesions. (1/700)
Four patients are described with destructive rheumatoid arthritis of the cervical spine and neurogenic wasting of forearm and hand muscles. The pathological connection is not immediately obvious, but a relationship between these two observations is described here with clinical, radiological, electrophysiological and necropsy findings. Compression of the anterior spinal artery at upper and mid-cervical levels is demonstrated to be the likely cause of changes lower in the spinal cord. These are shown to be due to the resulting ischaemia of the anterior part of the lower cervical spinal cord, with degeneration of the neurones innervating the forearm and hand muscles. These findings favour external compression of the anterior spinal artery leading to ischaemia in a watershed area as the likeliest explanation for this otherwise inappropriate and bizarre phenomenon. (+info)A clinical study of motor evoked potentials using a triple stimulation technique. (2/700)
Amplitudes of motor evoked potentials (MEPs) are usually much smaller than those of motor responses to maximal peripheral nerve stimulation, and show marked variation between normal subjects and from one stimulus to another. Consequently, amplitude measurements have low sensitivity to detect central motor conduction failures due to the broad range of normal values. Since these characteristics are mostly due to varying desynchronization of the descending action potentials, causing different degrees of phase cancellation, we applied the recently developed triple stimulation technique (TST) to study corticospinal conduction to 489 abductor digiti minimi muscles of 271 unselected patients referred for possible corticospinal dysfunction. The TST allows resynchronization of the MEP, and thereby a quantification of the proportion of motor units activated by the transcranial stimulus. TST results were compared with those of conventional MEPs. In 212 of 489 sides, abnormal TST responses suggested conduction failure of various degrees. By contrast, conventional MEPs detected conduction failures in only 77 of 489 sides. The TST was therefore 2.75 times more sensitive than conventional MEPs in disclosing corticospinal conduction failures. When the results of the TST and conventional MEPs were combined, 225 sides were abnormal: 145 sides showed central conduction failure, 13 sides central conduction slowing and 67 sides both conduction failure and slowing. It is concluded that the TST is a valuable addition to the study of MEPs, since it improves detection and gives quantitative information on central conduction failure, an abnormality which appears to be much more frequent than conduction slowing. This new technique will be useful in following the natural course and the benefit of treatments in disorders affecting central motor conduction. (+info)Cauda equina syndrome in ankylosing spondylitis: a report of six cases. (3/700)
Six patients with ankylosing spondylitis and features of a cauda equina syndrome are described. The myelographic findings are discussed in relation to the pathogenesis of the disorder and its natural history. Present experience suggests that the cauda equina syndrome is a more common complication of ankylosing spondylitis than is usually thought. (+info)A clinico-pathological study of cervical myelopathy in rheumatoid arthritis: post-mortem analysis of two cases. (4/700)
Two patients who developed cervical myelopathy secondary to rheumatoid arthritis were analyzed post mortem. One patient had anterior atlanto-axial subluxation (AAS) combined with subaxial subluxation (SS), and the other had vertical subluxation (VS) combined with SS. In the patient with AAS, the posterior aspect of the spinal cord demonstrated severe constriction at the C2 segment, which arose from dynamic osseous compression by the C1 posterior arch. A histological cross-section of the spinal cord at the segment was characterized by distinct necrosis in the posterior white columns and the gray matter. In the patient with VS, the upper cervical cord and medulla oblongata showed angulation over the invaginated odontoid process, whereas no significant pathological changes were observed. At the level of SS, the spinal cord was pinched and compressed between the upper corner of the vertebral body and the lower edge of the lamina. Histologically, demyelination and gliosis were observed in the posterior and lateral white columns. (+info)MR of CNS sarcoidosis: correlation of imaging features to clinical symptoms and response to treatment. (5/700)
BACKGROUND AND PURPOSE: Sarcoidosis is an idiopathic systemic granulomatous disease, recognized in a patient when clinical and radiologic findings are confirmed by histopathologic analysis. The objective was to identify a relationship between MR imaging and clinical findings in CNS sarcoidosis. METHODS: The clinical charts of 461 patients with biopsy-proved sarcoidosis were reviewed retrospectively. Criteria for including patients in the study included those with symptoms referable to the CNS, excluding those with another explanation for their symptoms, those with headaches or other subjective complaints without accompanying objective findings, and those with peripheral neuropathy other than cranial nerve involvement or myopathy without CNS manifestations. Thirty-four of 38 patients whose conditions met the criteria for CNS sarcoidosis underwent a total of 82 MR examinations. The positive imaging findings were divided into categories as follows: pachymeningeal, leptomeningeal, nonenhancing brain parenchymal, enhancing brain parenchymal, cranial nerve, and spinal cord and nerve root involvement. Treatment response, clinical symptomatology, and any available histopathologic studies were analyzed with respect to imaging manifestations in each of the categories. RESULTS: Eighty-two percent of the patients with sarcoidosis with neurologic symptoms referable to the CNS had findings revealed by MR imaging. However, eight (40%) of 20 cranial nerve deficits seen at clinical examination of 13 patients were not seen at contrast-enhanced MR imaging, and 50% of the patients with symptoms referable to the pituitary axis had no abnormal findings on routine contrast-enhanced MR images. In contradistinction, 44% of 18 cranial nerves in nine patients with MR evidence of involvement had no symptoms referable to the involved cranial nerve. Clinical and radiologic deterioration occurred more commonly with leptomeningeal and enhancing brain parenchymal lesions. CONCLUSION: MR imaging can be used to confirm clinical suspicion and to show subclinical disease and the response of pathologic lesions to treatment. (+info)Idiopathic spinal cord herniation: value of MR phase-contrast imaging. (6/700)
We report two patients with an idiopathic transdural spinal cord herniation at the thoracic level. Phase-contrast MR imaging was helpful in showing an absence of CSF flow ventral to the herniated cord and a normal CSF flow pattern dorsal to the cord, which excluded a compressive posterior arachnoid cyst. (+info)Myelopathy due to calcification of the cervical ligamenta flava: a report of two cases in West Indian patients. (7/700)
Two cases of cervical myelopathy due to calcification of the ligamenta flava (CLF) are described for the first time in black patients from the French West Indies. A pre-operative CT scan differentiated the diagnosis from one of ossification of the ligamenta flava. Microanalysis on the operatively excised specimen in one patient revealed a mixture of calcium pyrophosphate dihydrate crystals and hydroxypatite crystals. Poor outcome in one patient contrasting with excellent recovery in the other one, who had undergone posterior decompressive laminectomy, emphasizes the importance of surgery in the management of CLF. (+info)Spinal xanthomatosis: a variant of cerebrotendinous xanthomatosis. (8/700)
We describe seven Dutch patients from six families with a slowly progressive, mainly spinal cord syndrome that remained for many years the sole expression of cerebrotendinous xanthomatosis (CTX). MRI demonstrated white matter abnormalities in the lateral and dorsal columns of the spinal cord. Post-mortem examination of one of the patients showed extensive myelin loss in these columns. An array of genotypes was found in these patients. We conclude that 'spinal xanthomatosis' is a clinical and radiological separate entity of CTX that should be included in the differential diagnosis of 'chronic myelopathy'. (+info)'Spinal cord diseases' refer to a group of medical conditions that affect the spinal cord's structure, function, or both, leading to various neurological symptoms such as pain, sensory loss, motor dysfunction, and autonomic disturbances.
Spinal cord diseases refer to a group of conditions that affect the spinal cord, which is a part of the central nervous system responsible for transmitting messages between the brain and the rest of the body. These diseases can cause damage to the spinal cord, leading to various symptoms such as muscle weakness, numbness, pain, bladder and bowel dysfunction, and difficulty with movement and coordination.
Spinal cord diseases can be congenital or acquired, and they can result from a variety of causes, including infections, injuries, tumors, degenerative conditions, autoimmune disorders, and genetic factors. Some examples of spinal cord diseases include multiple sclerosis, spina bifida, spinal cord injury, herniated discs, spinal stenosis, and motor neuron diseases such as amyotrophic lateral sclerosis (ALS).
The treatment for spinal cord diseases varies depending on the underlying cause and severity of the condition. Treatment options may include medication, physical therapy, surgery, and rehabilitation. In some cases, the damage to the spinal cord may be irreversible, leading to permanent disability or paralysis.
The spinal cord is a major part of the central nervous system, consisting of a thick bundle of nerve fibers and associated tissue that extends from the brainstem to the lower back, transmitting signals between the brain and the rest of the body for motor control, sensory perception, and autonomic functions.
The spinal cord is a major part of the nervous system, extending from the brainstem and continuing down to the lower back. It is a slender, tubular bundle of nerve fibers (axons) and support cells (glial cells) that carries signals between the brain and the rest of the body. The spinal cord primarily serves as a conduit for motor information, which travels from the brain to the muscles, and sensory information, which travels from the body to the brain. It also contains neurons that can independently process and respond to information within the spinal cord without direct input from the brain.
The spinal cord is protected by the bony vertebral column (spine) and is divided into 31 segments: 8 cervical, 12 thoracic, 5 lumbar, 5 sacral, and 1 coccygeal. Each segment corresponds to a specific region of the body and gives rise to pairs of spinal nerves that exit through the intervertebral foramina at each level.
The spinal cord is responsible for several vital functions, including:
1. Reflexes: Simple reflex actions, such as the withdrawal reflex when touching a hot surface, are mediated by the spinal cord without involving the brain.
2. Muscle control: The spinal cord carries motor signals from the brain to the muscles, enabling voluntary movement and muscle tone regulation.
3. Sensory perception: The spinal cord transmits sensory information, such as touch, temperature, pain, and vibration, from the body to the brain for processing and awareness.
4. Autonomic functions: The sympathetic and parasympathetic divisions of the autonomic nervous system originate in the thoracolumbar and sacral regions of the spinal cord, respectively, controlling involuntary physiological responses like heart rate, blood pressure, digestion, and respiration.
Damage to the spinal cord can result in various degrees of paralysis or loss of sensation below the level of injury, depending on the severity and location of the damage.
"Spinal cord injuries refer to damage to the spinal cord's nerve fibers, which can result in loss of muscle function, sensation, or autonomic nervous system regulation below the level of injury."
Spinal cord injuries (SCI) refer to damage to the spinal cord that results in a loss of function, such as mobility or feeling. This injury can be caused by direct trauma to the spine or by indirect damage resulting from disease or degeneration of surrounding bones, tissues, or blood vessels. The location and severity of the injury on the spinal cord will determine which parts of the body are affected and to what extent.
The effects of SCI can range from mild sensory changes to severe paralysis, including loss of motor function, autonomic dysfunction, and possible changes in sensation, strength, and reflexes below the level of injury. These injuries are typically classified as complete or incomplete, depending on whether there is any remaining function below the level of injury.
Immediate medical attention is crucial for spinal cord injuries to prevent further damage and improve the chances of recovery. Treatment usually involves immobilization of the spine, medications to reduce swelling and pressure, surgery to stabilize the spine, and rehabilitation to help regain lost function. Despite advances in treatment, SCI can have a significant impact on a person's quality of life and ability to perform daily activities.
C. U. Velmurugendran
Diseases of the Spinal Cord. Springer Science & Business Media. 2012. ISBN 9781447133537. Retrieved 10 February 2016. "Padma ... Edmund Critchley, Andrew Eisen (Editors) (2012). Diseases of the Spinal Cord. Springer Science & Business Media. p. 453. ISBN ... Tirupati and has contributed chapters to books including Diseases of the Spinal Cord, published in 2012. The Government of ...
Blood-spinal cord barrier
... making treatment of spinal cord diseases difficult. Furthermore, drugs that do pass through the barrier may be subjected to ... Blood-spinal cord barrier permeability in experimental spinal cord injury: dynamic contrast-enhanced MRI. NMR Biomed 2009;22: ... Because of its function as a protective barrier for the spinal cord, disruption of the BSCB exposes spinal cord tissue to ... The cross-talk between autophagy and endoplasmic reticulum stress in blood-spinal cord barrier disruption after spinal cord ...
Spinal cord stimulator
"Spinal cord stimulation for Parkinson's disease: a systematic review". Neurosurgical Review. 39 (1): 27-35, discussion 35. doi: ... There are also spinal cord stimulators under research and development that could enable patients with spinal cord injury to ... the spinal cord. In September 2018, Mayo Clinic and UCLA reported that spinal cord stimulation supported with physical therapy ... of lead migration for spinal cord stimulation. The neurophysiological mechanisms of action of spinal cord stimulation are not ...
Syringomyelia
Diseases of the Spine and Spinal Cord. Carol DerSarkissian, MD, ed. (11 November 2021). "Pain Management: Arachnoiditis". WebMD ... It is most usually observed in the part of the spinal cord corresponding to the neck area. Symptoms are due to spinal cord ... The diagnosis is confirmed with a spinal CT, myelogram or MRI of the spinal cord. The cavity may be reduced by surgical ... If the syrinx is higher up in the spinal cord or affecting the brainstem, as in syringobulbia, vocal cord paralysis, ...
Brain abscess
Macewan W (1893). Pyogenic Infective Diseases of the Brain and Spinal Cord. Glasgow: James Maclehose and Sons. Ingraham FD, ... Brain abscess is usually associated with congenital heart disease in young children. It may occur at any age but is most ... Raimondi AJ, Matsumoto S, Miller RA (December 1965). "Brain abscess in children with congenital heart disease. I". Journal of ... congenital heart disease with right-to-left shunts often result in abscesses in the distribution of the middle cerebral artery ...
Nutritional muscular dystrophy
"Degenerative Diseases of the Spinal Column and Cord - Nervous System". Merck Veterinary Manual. Retrieved 2019-09-05. Burns, ... Commons category link is on Wikidata, Sheep and goat diseases, Bovine diseases, Horse diseases). ... The diseases are characterized by the damage and degeneration of the central nervous system. This disease process is heritable ... Nutritional Muscular Dystrophy (Nutritional Myopathy or White Muscle Disease) is a disease caused by a deficiency of selenium ...
Friedreich's ataxia
The disease primarily affects the spinal cord and peripheral nerves. The spinal cord becomes thinner and nerve cells lose some ... The spinal cord becomes thinner, and nerve cells lose some myelin sheath. In February 2023, the first approval of a treatment ... The motor neurons of the spinal cord are affected to a lesser extent than sensory neurons. In peripheral nerves, a loss of ... MRI and CT scans of brain and spinal cord are done to rule out other neurological conditions. Finally, a genetic test is ...
Peter Staats
Erdek MA, Staats PS (2003). "Spinal cord stimulation for angina pectoris and peripheral vascular disease". Anesthesiol Clin ...
Satralizumab
NMOSD is a rare autoimmune disease of the central nervous system that mainly affects the optic nerves and spinal cord. In ... "FDA Approves Treatment for Rare Disease Affecting Optic Nerves, Spinal Cord". U.S. Food and Drug Administration (FDA). 17 ... Patients with NMO and NMOSD have elevated levels of IL-6 in cerebro-spinal fluid and serum during periods of active disease. ... most often those in the optic nerves and spinal cord. Individuals with NMOSD typically have attacks of optic neuritis, which ...
Galen
He even dealt with diseases affecting the spinal cord and nerves. In his work De motu musculorum, Galen explained the ... Galen went on to be the first physician to study what happens when the spinal cord is transected on multiple different levels. ... spinal cord, and vertebral column. Galen also played a major role in the discoveries of the Central Nervous System. He was also ... He had first-hand knowledge of the disease, and was present in Rome when it first struck in 166, and was also present in the ...
Neuromyelitis optica spectrum disorder
The most common initial manifestation of the disease is inflammation of the spinal cord (myelitis). Myelitis causes spinal cord ... in patients with long-standing MS resulting in confluent spinal cord lesions mimicking the longitudinally extensive spinal cord ... "FDA Approves New Therapy for Rare Disease Affecting Optic Nerve, Spinal Cord". U.S. Food and Drug Administration (FDA) (Press ... "FDA Approves Treatment for Rare Disease Affecting Optic Nerves, Spinal Cord". U.S. Food and Drug Administration (FDA). 17 ...
MMP3
"Neutrophils mediate blood-spinal cord barrier disruption in demyelinating neuroinflammatory diseases". Journal of Immunology. ... barrier and blood-spinal cord barrier permeability allows for more neutrophils to infiltrate the brain and spinal cord at the ... early blood-spinal cord barrier disruption and hemorrhage and impairs long-term neurological recovery after spinal cord injury ... MMP-3 also does damage to the blood-spinal cord barrier (BSCB), the functional equivalent of the blood-brain barrier, after ...
Neuromechanics
They cannot detect disease in the spinal cord or the brain. In most disorders of the muscle, nerve, or neuromuscular junction, ... was increased and on occasion separated from the M2 spinal reflex response. The separation between the M2 and M3 spinal reflex ... Claus, D; Schöcklmann, HO; Dietrich, HJ (1986). "Long latency muscle responses in cerebellar diseases". European Archives of ... Aminoff, [edited by] William F. Brown, Charles F. Bolton, Michael J. (2002). Neuromuscular function and disease : basic, ...
Chugai Pharmaceutical Co.
"FDA Approves Treatment for Rare Disease Affecting Optic Nerves, Spinal Cord". U.S. Food and Drug Administration. 17 August 2020 ... for treatment of the orphan disease neuromyelitis optica Biotech and pharmaceutical companies in the New York metropolitan area ...
Inebilizumab
"FDA Approves New Therapy for Rare Disease Affecting Optic Nerve, Spinal Cord". U.S. Food and Drug Administration (FDA) (Press ... a rare autoimmune disorder in which immune system cells and autoantibodies attack and damage the optic nerves and spinal cord. ... Clinically, the disease is manifested with attacks/relapses that result in neurological impairment such as blindness, ... making neuromyelitis optica spectrum disorder a chronically debilitating and potentially life-threatening disease. The label ...
Surfer's myelopathy
Acton, Ashton (2012-12-26). Spinal Cord Vascular Diseases-Advances in Research and Treatment: 2012 Edition: ScholarlyPaper. ... such as the anterior spinal artery, can become kinked, depriving the spinal cord of oxygen. Although the condition derives its ... Surfer's myelopathy is a rare, nontraumatic spinal cord injury caused by hyperextension of the back injury and resulting in ... Rehabilitation in spinal cord injury Hawkes, Christopher H.; Sethi, Kapil D.; Swift, Thomas R. (2016-03-29). Instant ...
John Abercrombie (physician)
Abercrombie, John (1828). Pathological and practical researches on diseases of the brain and the spinal cord. Edinburgh: Waugh ... Pathological and Practical Researches on Diseases of the Brain and Spinal Cord, regarded as the first textbook in ... neuropathology, and Researches on the Diseases of the Intestinal Canal, Liver and other Viscera of the Abdomen, both published ...
William Gowers (neurologist)
The Diagnosis of Diseases of the Spinal Cord, (London: J & A Churchill, 1880). Epilepsy and other Chronic Convulsive Disorders ... A Manual of Diseases of the Nervous System, Vol 1, (London: J & A Churchill, 1886). A Manual of Diseases of the Nervous System ... Gowers produced the majority of his major works, including the two-volume Manual of Diseases of the Nervous System, in the ... The book is still used today by medical professionals as a primary reference for this disease.[citation needed] A master of ...
Paralyzed Veterans of America
The primary focus of PVA services is veterans with spinal cord injuries and diseases; it extends support to able-bodied, ill, ... The organization was created to allow its members, veterans of the armed forces living with spinal cord injuries or diseases ... improved quality of life for everyone with spinal cord injury or disorders SCI/D, and diseases like MS and ALS. The PVA ... PVA promotes state-of-the-art healing facilities for spinal cord injured veterans at VA hospitals, as well as barrier-free ...
Carl Nipperdey
Nipperdey fell ill with a nerve and spinal cord disease, which got progressively worse; in January 1875 he died by suicide. ...
Pierre Marie
English translation by M. Lubbock as "Lectures on Diseases of the Spinal Cord", London, 1895. Sur l'hérédo-ataxie cérébelleuse ... "Marie-Strümpel Disease": also known as ankylosing spondylitis; a severe arthritic spinal deformity. Named along with German ... Charcot-Marie-Tooth disease Archived 2011-05-14 at the Wayback Machine @ Who Named It Tumblety, Joan (2012). Remaking the Male ... His analysis of the disease was an important contribution in the emerging field of endocrinology. Marie is also credited as the ...
James Hill (surgeon)
Abercrombie J. Pathological and practical researches on diseases of the brain and the spinal cord. Edinburgh: Printed for Waugh ... Hill concluded that syphilis and sibbens were the same disease and that sibbens, having been introduced into a family by sexual ... Hill was clear that sibbens and what he termed West Indian yaws were distinct diseases. Subsequent writers credited Hill and ... His report on two cases of hydatid disease describes one patient discharging hydatid cysts via a chronic cutaneous fistula from ...
Spinal tumor
"Spinal Cord Tumors: New Views and Future Directions". Neurologic Clinics. Spinal Cord Diseases. 31 (1): 241-268. doi:10.1016/j. ... Spinal tumors are neoplasms located in either the vertebral column or the spinal cord. There are three main types of spinal ... Spinal cord compression is commonly found in patients with metastatic malignancy. Back pain is a primary symptom of spinal cord ... Spinal cord tumors are classified based on their location within the spinal cord: intradural (intradmedullary and ...
Outline of the human brain
Multiple sclerosis - an inflammatory disease in which the myelin sheaths around the axons of the brain and spinal cord are ... Spinal cord - many neurons originate or terminate in the brain and extend down into the spinal column. The spinal cord itself ... Neuropathology - biopsy of tissue from the brain and spinal cord to aid in diagnosis of disease. Frequent neurosurgery ... but synapse in the spinal cord. This characteristic allows reflex actions to occur relatively quickly by activating spinal ...
Central Institute for Experimental Animals
Developing spinal cord injury model and Parkinson's disease model using the common marmoset (New World monkey). Establishment ...
Julius Althaus
On sclerosis of the spinal cord: including locomotor ataxy, spastic spinal paralysis, and other system-diseases of the spinal ... "Charcot's disease" after the disease's first descriptor, Jean-Martin Charcot. He gave two lectures on spinal cord sclerosis in ... On infantile paralysis and some allied diseases of the spinal cord: their diagnosis and treatment, 1878. Functions of the brain ... This facility in Regent's Park later became the Maida Vale Hospital for Nervous Diseases and it is now part of National ...
Lateral grey column
Benzel, E., Waxman, C., Stephen, G., Byrne, T. N. "Diseases of the Spine and Spinal Cord." Oxford University Press, USA, 2000. ... lateral horn of spinal cord, intermediolateral column) is one of the three grey columns of the spinal cord (which give the ... Each of these roots is the end of a spinal nerve connecting the spinal cord to the body. The vertebral column is divided into ... The spinal cord is divided into 31 segments, located between the vertebrae. Each segment is defined by a posterior root ...
HĹŤĹŤ UmagorĹŤ
He later developed spinal cord disease and passed away at the young age of 40, in 1907. In 1974, Nishonoseki stable wrestler ...
Caudal cell mass
The caudal cell mass plays a role in many diseases and abnormalities related to the spinal cord. One group of abnormalities it ... The caudal end of the spinal cord first begins to form after primary neurulation has taken place, indicating that it develops ... or abnormalities in which the spinal cord and the complementary organ systems may be malformed. Some of the abnormalities that ... it could result in a type of spinal dysraphism. One example of spinal dysraphism is caudal regression syndrome. Patients with ...
P. A. L. Wight
Wight, P. a. L. (1960). A histological study of the spinal cord and peripheral nervous system in scrapie disease of sheep ( ... The Histopathology of Marek's Disease Oregon Disease in Turkeys Who's Who in Commerce and Industry vol 14 SILLER, WALTER G. " ... Here he mainly worked on mainstream African animal diseases such as Heartwater and Rabies. As these involve the animal's ...
Anne Haney Cross
"Spinal Cord Tract Diffusion Tensor Imaging Reveals Disability Substrate in Demyelinating Disease". Neurology. 80 (24): 2201- ... Cross later found that DTI could also be used to effectively detect spinal cord tissue injury as well in ms and neuromyelitis ... "Radial Diffusivity Predicts Demyelination in Ex Vivo Multiple Sclerosis Spinal Cords". NeuroImage. 55 (4): 1454-1460. doi: ... This process is thought to be similar to the onset of autoimmune disease in humans when a complex protein antigen is the ...
Spinal Cord Diseases | MedlinePlus
Read about diseases of the spinal cord, the bundle of nerves running down the middle of your back. It carries signals between ... Advances in Brain and Spinal Cord Tumor Research (National Cancer Institute) * Key Statistics for Brain and Spinal Cord Tumors ... The primary NIH organization for research on Spinal Cord Diseases is the National Institute of Neurological Disorders and ... Brain and Spinal Cord Tumors in Adults (American Cancer Society) * Brown-Sequard Syndrome (National Institute of Neurological ...
Spinal Cord Trauma and Related Diseases: Background, Pathophysiology, Epidemiology
Spinal cord disease can result from diverse pathologic processes including trauma. Irrespective of the pathogenesis, it can ... encoded search term (Spinal Cord Trauma and Related Diseases) and Spinal Cord Trauma and Related Diseases What to Read Next on ... Spinal trauma and other spinal cord diseases often cause severe physical impairment secondary to motor, sensory, and autonomic ... Retraining the human spinal cord. Lin VW, ed. Spinal Cord Medicine: Principles and Practice. New York, NY: Demos; 2003. 817-26 ...
Paralyzed Veterans of America Educates Hundreds of Spinal Cord Injury and Disease Health Care Professionals at 6th Annual...
"Our goal is to ensure that health care providers who work in specialty care fields such as spinal cord injury and disease have ... Paralyzed Veterans of America Educates Hundreds of Spinal Cord Injury and Disease Health Care Professionals at 6th Annual ... treatments and therapies in spinal cord injury or disease (SCI/D), multiple sclerosis (MS) and amyotrophic lateral sclerosis ( ... and other equipment to assist individuals living with spinal cord injury or disease live life to the fullest. ...
Disease - Spinal cord trauma
Spinal cord trauma. Spinal cord injury; Compression of spinal cord; SCI; Cord compression ... Spinal cord trauma is damage to the spinal cord. It may result from direct injury to the cord itself or indirectly from disease ... which normally protects the spinal cord. Injury can also occur if the spinal canal protecting the spinal cord has become too ... The spinal cord contains nerve fibers and cells. These nerve fibers carry messages between your brain and body. The spinal cord ...
Characterization of spatiotemporal gait characteristics in clinically normal dogs and dogs with spinal cord disease in:...
Animals-42 clinically normal dogs and 24 dogs with myelopathy at spinal cord segment T3-L3. Procedures-Gait was analyzed for ... of spatiotemporal gait characteristics appears to have potential for use as an outcome measure for dogs with neurologic disease ... the spatiotemporal gait characteristics and associated covariates of clinically normal dogs and dogs with spinal cord disease. ... Twenty-four dogs with neurologic disease (22 with intervertebral disk disease and 2 with spinal cord trauma) with a median age ...
Effects of spinal cord stimulation on postural control in Parkinson's disease patients with freezing of gait | eLife
Effects of spinal cord stimulation on postural control in Parkinsons disease patients with freezing of gait. ... Effects of spinal cord stimulation on postural control in Parkinsons disease patients with freezing of gait ... Effects of spinal cord stimulation on postural control in Parkinsons disease patients with freezing of gait ... Spinal cord stimulation (SCS) is a promising intervention for FoG in patients with PD, however its effects on distinct domains ...
Feline Traumatic Spinal Cord Diseases, Clinical Evaluation and How to Achieve Best Outcome - WSAVA 2015 Congress - VIN
Further investigation is necessary to demonstrate the spinal cord integrity. However, a structurally intact spinal cord seen on ... Feline Traumatic Spinal Cord Diseases, Clinical Evaluation and How to Achieve Best Outcome ... Following traumatic spinal cord injury (SCI), one of the main concerns from cat-owners is whether their cat can recover (i.e., ... From the neuro-exam, try to localize the lesion anatomically to the regions: C1-5, C6-T2, T3-L3, L4-S3 spinal cord segments. ...
Other Primary Demyelinating Diseases - Brain, Spinal Cord, and Nerve Disorders - MSD Manual Consumer Version
Other Primary Demyelinating Diseases - Learn about the causes, symptoms, diagnosis & treatment from the MSD Manuals - Medical ... Much like the insulation... read more of nerves in the brain and spinal cord. Acute disseminated encephalomyelitis is more ... A spinal tap Spinal Tap Diagnostic procedures may be needed to confirm a diagnosis suggested by the medical history and ... These fats accumulate mainly in the brain, spinal cord, and adrenal glands. In the brain, they cause demyelination of nerves. ...
Perceptions of Adults With Spinal Cord Injury or Disease Before and After Riding in an Autonomous Shuttle | Citedby Results |...
Nervous System Diseases - Spinal Cord Injuries | CU Experts | CU Boulder
Nervous System Diseases - Spinal Cord Injuries PubMed MeSh Term *Overview. Overview. subject area of * (+)-Naloxone, an Opioid- ... Spinal Cord Injury in Rats Disrupts the Circadian System Journal Article * Spinal Cord Injury in Rats Dysregulates Diurnal ... An automated pressure-swing absorption system to administer low oxygen therapy for persons with spinal cord injury Journal ... Mild to Moderate Sleep Apnea Is Linked to Hypoxia-induced Motor Recovery after Spinal Cord Injury Journal Article ...
Spinal Cord Trauma and Related Diseases Differential Diagnoses
Spinal cord disease can result from diverse pathologic processes including trauma. Irrespective of the pathogenesis, it can ... encoded search term (Spinal Cord Trauma and Related Diseases) and Spinal Cord Trauma and Related Diseases What to Read Next on ... Retraining the human spinal cord. Lin VW, ed. Spinal Cord Medicine: Principles and Practice. New York, NY: Demos; 2003. 817-26 ... Spinal cord injury medicine. 5. Preserving wellness and independence of the aging patient with spinal cord injury: a primary ...
Spinal Cord Injury | Diseases and Disorders
Spinal Cord Injury answers are found in the Diseases and Disorders powered by Unbound Medicine. Available for iPhone, iPad, ... Sommers, Marilyn Sawyer.. "Spinal Cord Injury." Diseases and Disorders, 6th ed., F.A. Davis Company, 2019. Nursing Central, ... Spinal Cord Injury [Internet]. In: Diseases and Disorders. F.A. Davis Company; 2019. [cited 2023 December 05]. Available from: ... nursing.unboundmedicine.com/nursingcentral/view/Diseases-and-Disorders/73718/5/Spinal_Cord_Injury PB - F.A. Davis Company ET - ...
Lamina X of the spinal cord in motor neuron disease
| Italian Journal of Anatomy and Embryology
The present data confirm the scarce NPC activity in the intact spinal cord which is enhanced by disease conditions; in the ... Lamina X of the spinal cord in motor neuron disease. Italian Journal of Anatomy and Embryology, 119(1), 86. Retrieved from ... A number of plastic events were described in the spinal cord in the course of amyotrophic lateral sclerosis (ALS). These ... due to the strong gliogenic effect of the spinal cord "milieu". In the present work, we used immunohistochemistry and electron ...
Spinal Cord Disease in Cats - EveryCat Health Foundation
Spinal cord disease is a diagnostic challenge in cats. As well, no antemortem studies on the relative frequency of the ... The authors reviewed the medical records of 92 cats with spinal cord disease that had undergone an MRI study. Seven diagnostic ... Clinical and magnetic resonance imaging findings in 92 cats with clinical signs of spinal cord disease. Journal of Feline ... Neuroanatomic diagnosis and specific spinal cord diseases. J Feline Med Surg 2009;11:361-372.. >> PubMed Abstract ...
Neurodegenerative diseases of the spinal cord treatment in India
... , ➤ 13 clinics, Addresses, $ Prices for treatments and ... Neurodegenerative diseases of the spinal cord treatment. Neurodegenerative diseases of the spinal cord treatment in India. ➠... Neurodegenerative diseases of the spinal cord treatment in other cities. New Delhi Chennai Mumbai Gurgaon Delhi Hyderabad ... We found 13 clinics specialized in neurodegenerative diseases of the spinal cord with cumulative rating ...
Neurological disease of the spinal cord - the description, diagnostics, treatment
Neurological disease often go undetected in the early stages, when people can get rid of serious disorders. Over time he will ... Neurological disease of the spinal cord - the description, diagnostics, treatment. Neurological disease of the spinal cord - ... Spinal stroke - a disease that violates the circulation in the spinal cord. Patients with suspected should be immediately ... Paresis in diseases of the spinal cord and spine: the main causes, treatment. read more... ...
Spinal Cord Diseases | University of Edinburgh Archive and Manuscript Collections
... intramedullary spinal tumour; disseminated scoliosis; brown-sequard lesion on spinal cord; and spinal cord disease. No ... Scope Note: Notes = Diseases of spinal cord,Created For = LHSA-Dott Found in 97 Collections and/or Records:. PR2.473, 1941-1942 ... Conditions mentioned include: progressive spinal cord disease; paraesthesiae; neuritis; and spastic paraparesis. No treatment ... Conditions mentioned include: spinal cord lesion; staggering; leg numbness; and spastic paraparesis. No treatment given. ...
Degenerative Disc Disease Waxahachie TX | Spinal Cord Decompression Mansfield TX
TX offers discectomy and fusion to treat degenerative disc disease, spinal cord decompression, spinal stenosis and ... Decompression of the spinal cord along with a discectomy and fusion will be performed to remove the affected disc and fuse the ... What is Degenerative Disc Disease?. Degenerative disc disease (DDD) refers to the gradual deterioration of the intervertebral ... Diagnosis of Degenerative Disc Disease. The diagnosis of degenerative disc disease comprises of complete medical history and ...
Spinal cord tumor - Care at Mayo Clinic - Mayo Clinic
Spinal cord tumors can cause serious problems such as pain and paralysis. Find out how more about management and treatment. ... Mayo Clinics world-renowned spinal tumor teams have been treating and removing spinal cord tumors for more than 100 years. ... Living with spinal cord tumor?. Connect with others like you for support and answers to your questions in the Proton Beam ... Each year, Mayo Clinic spinal cord tumor experts provide comprehensive care for nearly 400 adults and children. ...
Conditions treated by Doctor Zannos Grekos, MD in Bonita Springs, FL
Tumors of the spinal cord - Diagnosis, Treatment - Causes,Symptoms,Diagnosis,Treatment,Analysis,disease
Tumors of the spinal cord - Diagnosis, Treatment. Anatomy of spinal cord. The spinal cord - a body. Along with the brain ... The spinal cord is located in the spinal canal, which is formed by the bodies and the vertebral arch. However, the spinal cord ... Intramedullary spinal cord tumors - they are in the matter of the spinal cord (make up about 5% of all spinal tumors). The most ... Tumors of the spinal cord. As in the case with brain tumors, spinal cord tumors is important to not look or structure of the ...
Generation of Human Oligodendrocyte Progenitors for Treatment of Demyelinating Diseases and Spinal Cord Injury
... spinal cord, or optic nerve. Similarly, spinal cord injury is typically accompanied by progressive demyelination of axons and ... Focal spinal cord chemical demyelination: Under isoflurane anesthesia and while spinal-clamped in a stereotaxic frame, a ... NSI-777 was also grafted into the mechanically injured rat spinal cord 7 days after injury. Spinal contusion was generated via ... Diseases such as Alzheimers disease (AD), Parkinsons disease (PD), and Multiple Sclerosis (MS) affect millions of individuals ...
Spinal arachnoid cyst
... operative and postoperative radiological examinations and operative notes of 31 patients with spinal arachnoid cyst operated on ... Spinal Cord Diseases / complications * Spinal Cord Diseases / pathology * Spinal Cord Diseases / surgery* ... Spinal arachnoid cyst J Clin Neurosci. 2011 Sep;18(9):1189-92. doi: 10.1016/j.jocn.2010.11.023. Epub 2011 Jul 2. ... Preoperative, operative and postoperative radiological examinations and operative notes of 31 patients with spinal arachnoid ...
Traumatic and non-traumatic spinal cord impairment in New Zealand: incidence and characteristics of people admitted to spinal...
Commentary on community participation following spinal cord injury in New Zealand. Top Spinal Cord Inj Rehabil 2010;15:63-71. ... Incidence, prevalence and epidemiology of spinal cord injury: what learns a worldwide literature survey? Spinal Cord 2006;44: ... Reference for the 2011 revision of the international standards for neurological classification of spinal cord injury. J Spinal ... Traumatic and non-traumatic spinal cord impairment in New Zealand: incidence and characteristics of people admitted to spinal ...
Article By Diseases
| Bentham Science
The Use of Erythropoietin and its Derivatives to Treat Spinal Cord Injury Journal: Mini-Reviews in Medicinal Chemistry Volume: ... Articles by Disease Articles By Disease Bentham is offering subject-based scholarly content collections which are tailored to ... Neural Stem Cell Niches in Health and Diseases Journal: Current Pharmaceutical Design Volume: 18 Page: 1755-1783 Author(s): ... Neurocysticercosis: The Enigmatic Disease Journal: Central Nervous System Agents in Medicinal Chemistry Volume: 11 Page: 261- ...
C. U. Velmurugendran - Wikipedia
Diseases of the Spinal Cord. Springer Science & Business Media. 2012. ISBN 9781447133537. Retrieved 10 February 2016. "Padma ... Edmund Critchley, Andrew Eisen (Editors) (2012). Diseases of the Spinal Cord. Springer Science & Business Media. p. 453. ISBN ... Tirupati and has contributed chapters to books including Diseases of the Spinal Cord, published in 2012. The Government of ...
Coronary artery disease and hypertension in a non-selected spinal cord injury patient population - Fingerprint
- Tel Aviv...
New Study Presents Cell-based Therapy for MN Diseases or Spinal Cord DisordersUNIST News Center | UNIST News Center
Spinal cord injuries (SCIs) tend to be devastating ... The spinal cord is a bundle of nerves inside the spine that ... The spinal cord is a bundle of nerves inside the spine that gives your body structure and support. Spinal cord injuries (SCIs) ... Home All News Research New Study Presents Cell-based Therapy for MN Diseases or Spinal Cord Disorders ... New Study Presents Cell-based Therapy for MN Diseases or Spinal Cord Disorders. Their findings have been published in eLife on ...
The Lionheart Community - GuideStar Profile
Spinal cord injuries and diseases. Show more subject areas Ă— Subject area. Health care access ... Queens of Spinal Cord Injury is a monthly support group for women with SCI/D and other disabilities. All are welcome no matter ... I sustained a spinal cord injury in 2000 from a snowboarding accident. In the beginning of my injury, I joined a mentoring ... An online community for those who want to connect with others that have spinal cord injuries or neurological challenges. We ...
InjuryNeurologicalInjuriesDisordersTraumaMultiple SclerosisCervicalDamage to the spinal cordNervesSpineAnatomyTraumaticStenosisDegenerative Disc DiSymptomsTumors in AdultsDiagnosisComplicationsParalysisIntramedullary spinalAmyotrophicSensoryAutoimmune diseasesSACRALArachnoid cystAdultsIntact spinal cordLesionLesionsPatientsNeurodegenerativeCentersExtraduralStrokeClinicalDiverse pathologic processesVertebralThoracicCompressionSubacuteCanalMeningitisOpticParaplegiaTractsShockIntervertebralIntraduralGaitSymptomTumorAffects
Injury47
- Considerable differences exist in terms of clinical complications after traumatic and nontraumatic spinal cord injury (SCI). (medscape.com)
- Trauma to the spinal cord typically leads to a combination of symptoms and signs resulting from immediate and delayed injury. (medscape.com)
- The cord fills the whole spinal canal at the injury level and leads to further secondary ischemia. (medscape.com)
- The annual Summit brings together doctors, nurses, occupational, recreational and physical therapists, social workers, psychologists, pharmacists and researchers to learn about the latest scientific advances, treatments and therapies in spinal cord injury or disease (SCI/D), multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS). (prnewswire.com)
- Our goal is to ensure that health care providers who work in specialty care fields such as spinal cord injury and disease have the most up-to-date information in research and best practices so they can bring that information back to their respective hospitals and immediately put it to use to improve the care of their patients. (prnewswire.com)
- The Summit EXPO will be open to attendees August 30 and 31st, and will feature the latest in technology, medical devices and supplies, and other equipment to assist individuals living with spinal cord injury or disease live life to the fullest. (prnewswire.com)
- Paralyzed Veterans of America is the only congressionally chartered veterans service organization dedicated solely for the benefit and representation of veterans with spinal cord injury or disease . (prnewswire.com)
- It may result from direct injury to the cord itself or indirectly from disease of the nearby bones, tissues, or blood vessels. (adam.com)
- A minor injury can damage the spinal cord. (adam.com)
- Injury can also occur if the spinal canal protecting the spinal cord has become too narrow ( spinal stenosis ). (adam.com)
- Injury is due to a weakened spine from aging or bone loss ( osteoporosis ) or spinal stenosis. (adam.com)
- Following traumatic spinal cord injury (SCI), one of the main concerns from cat-owners is whether their cat can recover (i.e., a "functional pet" that can walk, able to regain urinary/fecal continence). (vin.com)
- O'Connor P. Incidence and patterns of spinal cord injury in Australia. (medscape.com)
- Priapism in acute spinal cord injury. (medscape.com)
- Tator CH, Fehlings MG. Review of clinical trials of neuroprotection in acute spinal cord injury. (medscape.com)
- Administration of methylprednisolone for 24 or 48 hours or tirilazad mesylate for 48 hours in the treatment of acute spinal cord injury. (medscape.com)
- Results of the Third National Acute Spinal Cord Injury Randomized Controlled Trial. (medscape.com)
- National Acute Spinal Cord Injury Study. (medscape.com)
- Ito Y, Sugimoto Y, Tomioka M, Kai N, Tanaka M. Does high dose methylprednisolone sodium succinate really improve neurological status in patient with acute cervical cord injury? (medscape.com)
- Sugarman B. Medical complications of spinal cord injury. (medscape.com)
- Comparison of medical complications following nontraumatic and traumatic spinal cord injury. (medscape.com)
- McDonald JW, Sadowsky C. Spinal-cord injury. (medscape.com)
- The development of evidence-informed physical activity guidelines for adults with spinal cord injury. (medscape.com)
- Biering-Sorensen B, Kristensen IB, Kjaer M, Biering-Sorensen F. Muscle after spinal cord injury. (medscape.com)
- Efficacy and safety of vardenafil in men with erectile dysfunction caused by spinal cord injury. (medscape.com)
- Chronic spinal cord injury. (medscape.com)
- A prospective assessment of mortality in chronic spinal cord injury. (medscape.com)
- 5. Preserving wellness and independence of the aging patient with spinal cord injury: a primary care approach for the rehabilitation medicine specialist. (medscape.com)
- Hagen EM, Faerestrand S, Hoff JM, Rekand T, Gronning M. Cardiovascular and urological dysfunction in spinal cord injury. (medscape.com)
- Nursing Central , nursing.unboundmedicine.com/nursingcentral/view/Diseases-and-Disorders/73718/5/Spinal_Cord_Injury. (unboundmedicine.com)
- DDD is a misnomer as it is not actually a disease but a condition that affects the strength, resilience and structural integrity of the intervertebral discs due to advancing age, trauma, injury, repetitive movement, improper posture or poor body mechanics. (ilyasspine.com)
- Hazel T, Hefferan M, Schwartz K, Yu N, Johe K, Levy M. Generation of Human Oligodendrocyte Progenitors for Treatment of Demyelinating Diseases and Spinal Cord Injury. (scientificarchives.com)
- This unmet medical need is a primary driver for the development of therapies based on transplantation of neural stem cells that have the potential to replace cells of the central nervous system (CNS) lost to disease or injury [1]. (scientificarchives.com)
- Similarly, spinal cord injury is typically accompanied by progressive demyelination of axons and concomitant neuronal atrophy [3]. (scientificarchives.com)
- Similarly, recovery of locomotor function after grafting of neural stem cells (NSC) in animal models of spinal cord injury has been demonstrated to be due at least in part to myelinating oligodendrocytes [11]. (scientificarchives.com)
- The research team further investigated the therapeutic effects of iMNs for treating traumatic spinal cord injury using rodent spinal cord injury model. (unist.ac.kr)
- We serve people presented with spinal cord injury or neurological injury and disorders. (guidestar.org)
- Queens of Spinal Cord Injury is a monthly support group for women with SCI/D and other disabilities. (guidestar.org)
- I sustained a spinal cord injury in 2000 from a snowboarding accident. (guidestar.org)
- Therefore, a sensory level to light touch may be absent unless both of these are involved (e.g., a complete injury that involves all spinal cord tracts). (emcrit.org)
- We are national leaders in the research field of bladder dysfunction and urinary symptoms that follow nervous system injury or disease. (medstarhealth.org)
- [ 1 ] Neurogenic bladder is a term applied to urinary bladder malfunction due to neurologic dysfunction emanating from internal or external trauma, disease, or injury. (medscape.com)
- The research may lead to treatments for motor neuron disease and spinal cord injury. (sci-info-pages.com)
- Physicians in the neurosciences program treat ailments including spinal cord injury, brain tumors, headaches, Parkinson's disease and stroke. (beckershospitalreview.com)
- Trauma is the most common cause of spinal cord injury. (medscape.com)
- Depression, disease and disability: application to patients with traumatic spinal cord injury. (bvsalud.org)
- spinal cord injury / lesion below C3. (who.int)
Neurological9
- A thorough neurological examination is fundamental to evaluate the spinal cord function and provide the client with a reasonable prognosis. (vin.com)
- There have been several trials of mesenchymal stem cells injected intravenously, intrathecally or both in relapsing remitting and in progressive MS. Results suggest that mesenchymal stem cells can slow the progression of disease and might improve neurological function. (scientificarchives.com)
- A longitudinal cohort study of people with spinal cord neurological impairment (SCI) in New Zealand is underway. (bmj.com)
- An online community for those who want to connect with others that have spinal cord injuries or neurological challenges. (guidestar.org)
- Researchers are making great strides toward developing gene-based strategies to treat a variety of inherited neurometabolic diseases characterized by severe neurological involvement. (news-medical.net)
- MOG (35-55) is able to induce autoantibody production and relapsing-remitting neurological disease causing extensive plaque-like demyelination. (anaspec.com)
- Using this information, we hope to develop techniques for diagnosing some of the most devastating neurological diseases and treat them by designing future Brain-Machine interfaces devices. (upstate.edu)
- Amyotrophic lateral sclerosis (ALS) is a rapidly progressive, fatal neurological disease. (cdc.gov)
- Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a rapidly progressive, fatal neurological disease that affects nerve cells in the brain and spinal cord, causing nerves in the muscle to die, thereby affecting voluntary muscle movement. (cdc.gov)
Injuries12
- Many spinal cord injuries and cauda equina syndrome cases are medical emergencies and need surgery right away. (adam.com)
- When spinal cord injuries are in the neck area, symptoms can affect the arms, legs, and middle of the body. (adam.com)
- When spinal injuries are at chest level, symptoms can affect the legs. (adam.com)
- When spinal injuries are at the lower back level, symptoms can affect one or both legs. (adam.com)
- Spine injuries can damage the spinal cord if they are at the upper portion of the lumbar spine or the lumbar and sacral nerve roots (cauda equina) if they are at the lower lumbar spine. (adam.com)
- Spinal cord injuries (SCIs) tend to be devastating and most are permanent. (unist.ac.kr)
- Recent research has shown that motor neuron obtained from skin cells could serve as potential treatments for spinal cord injuries, and thus has received considerable research attention. (unist.ac.kr)
- With this, a new door has been opened for treating not only spinal cord injuries, caused by workplace accidents and car crashes, but also Lou Gehrig's disease, known as amyotrophic lateral sclerosis or ALS. (unist.ac.kr)
- Causes of spinal cord disorders include injuries include infections, a blocked blood supply, and compression by a fractured bone or a tumor. (nomsdrs.com)
- In addition to providing insight into the development and circuit formation of this critical population of neurons, these results might lead to the future ability to treat motor neuron disorders and spinal cord injuries. (sci-info-pages.com)
- These neurons degenerate in motor neuron diseases, and their damage contributes to loss of motor function in spinal cord injuries. (sci-info-pages.com)
- Hill, M 2023, ' Cardiopulmonary Health in Middle-aged People with Long-term Cervical and Upper Thoracic Spinal Cord Injuries ', Doctor, Department of Health Sciences, Lund. (lu.se)
Disorders7
- Freezing of gait (FoG) in Parkinson's disease (PD) is an incapacitating transient phenomenon, followed by continuous postural disorders. (elifesciences.org)
- Acute and chronic disorders such as MS, neuromyelitis optica spectrum disorder, transverse myelitis, and optic neuritis result in progressive demyelination of nerve axons in the brain, spinal cord, or optic nerve. (scientificarchives.com)
- In a recent clinical trial, a gene therapy to treat cerebral adrenoleukodystrophy (CALD) -- a neurodegenerative disease that typically claims young boys' lives within 10 years of diagnosis -- effectively stabilized the disease's progression in 88 percent of patients, researchers from the Dana-Farber/Boston Children's Cancer and Blood Disorders Center and Massachusetts General Hospital report today. (news-medical.net)
- Viking Therapeutics, Inc., a clinical-stage biopharmaceutical company focused on the development of novel, first-in-class or best-in-class therapies for metabolic and endocrine disorders, today announced that it has submitted an investigational new drug (IND) application to the U.S. Food and Drug Administration to conduct a Phase 2 study of VK2809 in patients with hypercholesterolemia and fatty liver disease. (news-medical.net)
- CDC takes concerns about vaccines and immune system diseases and disorders very seriously. (cdc.gov)
- International experts show how to generate state-of-the-art images and define diagnoses from crucial clinical/pathologic MR imaging correlations for neurologic, neurosurgical, and psychiatric diseases spanning fetal CNS anomalies to disorders of the aging brain. (chipsbooks.com)
- The risk of developing MS increases if a person has other autoimmune disorders, such as thyroid disease , rheumatoid arthritis , pernicious anemia , psoriasis , type 1 diabetes or inflammatory bowel disease . (medicinenet.com)
Trauma2
- Spinal cord disease can result from diverse pathologic processes including trauma . (medscape.com)
- Spinal cord trauma is damage to the spinal cord. (adam.com)
Multiple Sclerosis6
- For specific nontraumatic neurologic diseases that affect the spinal cord, see Multiple Sclerosis , Amyotrophic Lateral Sclerosis , and other articles listed in Differentials. (medscape.com)
- Diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), and Multiple Sclerosis (MS) affect millions of individuals in the US at a cost of hundreds of billions of dollars annually. (scientificarchives.com)
- In 1998, some research caused concern that hepatitis B vaccination might be linked with multiple sclerosis (MS), a progressive nerve disease. (cdc.gov)
- Multiple sclerosis (MS) external icon is an autoimmune disease that affects the brain and spinal cord (central nervous system). (cdc.gov)
- Multiple sclerosis ( MS ) is a potentially disabling autoimmune disease that affects the brain and spinal cord (central nervous system). (medicinenet.com)
- Nerves in any part of the brain or spinal cord may be damaged causing multiple sclerosis symptoms to appear in many parts of the body. (medicinenet.com)
Cervical3
- Nerves to the cervical cord are located closest to the middle of the cord, whereas nerves to the sacrum are located farthest towards the edges of the spinal cord. (emcrit.org)
- Lhermitte's sign (an electric-shock sensation elicited by neck flexion that runs down the spine and sometimes into the limbs) suggests involvement of the posterior columns of the cervical spinal cord. (emcrit.org)
- The spinal cord is located inside the vertebral canal, which is formed by the foramina of 7 cervical, 12 thoracic, 5 lumbar, and 5 sacral vertebrae, which together form the spine. (medscape.com)
Damage to the spinal cord1
- Along with motor and sensory deficits, damage to the spinal cord can cause long-term complications, including limited mobility. (unist.ac.kr)
Nerves11
- Your spinal cord is a bundle of nerves that runs down the middle of your back. (medlineplus.gov)
- If spinal cord pressure can be relieved or reduced before the spinal nerves are completely destroyed, paralysis may improve. (adam.com)
- of nerves in the brain and spinal cord. (msdmanuals.com)
- The spinal cord is a bundle of nerves inside the spine that gives your body structure and support. (unist.ac.kr)
- Spinal nerves and corresponding sensory dermatomes are shown above. (emcrit.org)
- Autonomic nerves run within the grey matter, near the center of the cord. (emcrit.org)
- MS is a disease that affects the spinal cord, brain and optic nerves. (yahoo.com)
- Located within the backbone, the spinal cord is tube-like and contains a bundle of nerves from the base of the brain down the back. (nomsdrs.com)
- It affects nerve cells in the brain and spinal cord, causing nerves in the muscle to die. (cdc.gov)
- The spinal nerves consist of the sensory nerve roots, which enter the spinal cord at each level, and the motor roots, which emerge from the cord at each level. (medscape.com)
- The spinal nerves are named and numbered according to the site of their emergence from the vertebral canal. (medscape.com)
Spine6
- If you have an accident that damages the vertebrae or other parts of the spine, this can also injure the spinal cord. (medlineplus.gov)
- The spinal cord is located in the spinal canal of your spine in your neck, chest, and back down to the first lumbar vertebra. (adam.com)
- Conditions such as rheumatoid arthritis , infection, cancer, or osteoporosis can weaken the spine, which normally protects the spinal cord. (adam.com)
- Decompression of the spinal cord along with a discectomy and fusion will be performed to remove the affected disc and fuse the adjoining vertebrae to stabilize the spine. (ilyasspine.com)
- Mayo Clinic doctors trained in spine conditions (neurologists) and spinal surgery (neurosurgeons and orthopedic surgeons) have experience in evaluating and treating people with vertebral tumors. (mayoclinic.org)
- Note that the spinal cord level doesn't line up precisely with the corresponding vertebrae, especially caudal to the thoracic spine. (emcrit.org)
Anatomy2
- This review focuses on spinal cord anatomy. (medscape.com)
- Basic clinical descriptions of common patterns of spinal cord involvement are related to essential aspects of spinal cord anatomy. (medscape.com)
Traumatic3
- Traumatic animals in shock should be treated prior to assess spinal cord function. (vin.com)
- Collignon F, Martin D, Lenelle J, Stevenaert A. Acute traumatic central cord syndrome: magnetic resonance imaging and clinical observations. (medscape.com)
- Management of acute traumatic central cord syndrome (ATCCS). (medscape.com)
Stenosis1
- Other conditions such as spinal stenosis and osteoarthritis (spondylosis) can also affect the intervertebral joints and spinal stability. (ilyasspine.com)
Degenerative Disc Di4
- Degenerative disc disease (DDD) refers to the gradual deterioration of the intervertebral discs between the vertebrae. (ilyasspine.com)
- Every patient is different, and it is important to realize that not everyone develops symptoms because of degenerative disc disease. (ilyasspine.com)
- The diagnosis of degenerative disc disease comprises of complete medical history and physical examination. (ilyasspine.com)
- If degenerative disc disease is present, the X-rays will often show a narrowing of the spaces between the vertebral bodies, which indicates that the disc has become very thin or has collapsed. (ilyasspine.com)
Symptoms6
- These symptoms can occur around the spinal cord, and also in other areas such as your arms and legs. (medlineplus.gov)
- The severity of the symptoms depends on whether the entire cord is injured (complete) or only partially injured (incomplete). (adam.com)
- The symptoms of brain diseases vary widely. (nomsdrs.com)
- however, the symptoms of chronic, untreated Lyme disease can occur at any time of the year. (cdc.gov)
- Symptoms may vary with people because of the location of affected nerve fibers and the severity of the disease. (medicinenet.com)
- As a result of dependence upon higher brain centers, certain lesions or diseases of the brain (eg, stroke, cancer, dementia) can result in a loss of voluntary control of the normal micturition reflex as well as symptoms such as urinary urgency. (medscape.com)
Tumors in Adults1
- Pain is the most common symptom of intramedullary spinal cord tumors in adults and 60-70% of patients with pain is the first sign of disease. (ucoz.com)
Diagnosis5
- Neuroanatomic diagnosis and specific spinal cord diseases. (everycat.org)
- For the diagnosis of tumors of the spinal cord is also applied this method of radiography, myelography as the - method, which is administered in the subarachnoid space of the spinal cord of contrast medium (eg air) and carrying out radiography. (ucoz.com)
- The first step towards diagnosis and therapy is recognizing that the patient has some sort of spinal cord pathology. (emcrit.org)
- A thorough investigation of patients with suspected neurosarcoidosis is recommended to establish the diagnosis, delineate the extent of disease, and guide therapy. (nih.gov)
- The diagnosis can be made by a laboratory testing for the cryptococcal antigen, X- ray of the lung, or examination of spinal fluid. (cdc.gov)
Complications1
- Drug therapy is aimed at stopping the progression of the disease and prevention of complications. (doclandmed.com)
Paralysis2
- Thus, diseases affecting the anterior horn of the spinal cord cause flaccid paralysis. (emcrit.org)
- A drug used to control Type II diabetes can help repair the spinal cords of mice suffering from the inherited disease adrenoleukodystrophy which, untreated, leads eventually to a paralysis, a vegetative state and death. (news-medical.net)
Intramedullary spinal1
- Intramedullary spinal cord tumors - they are in the matter of the spinal cord (make up about 5% of all spinal tumors). (ucoz.com)
Amyotrophic3
- A number of plastic events were described in the spinal cord in the course of amyotrophic lateral sclerosis (ALS). (fupress.net)
- this group of diseases include Friedreich's ataxia, hereditary spastic paraplegia, cerebellar ataxia, amyotrophic lateral sclerosis. (doclandmed.com)
- Parker Beam, 71, was diagnosed with amyotrophic lateral sclerosis, better known as ALS or Lou Gehrig's disease, last year. (manufacturing.net)
Sensory5
- Evaluating for a sensory level using a pin to detect pain sensation is more sensitive to detect a spinal level originating from a lesion in the spinothalamic tract. (emcrit.org)
- Patients with partial cord involvement may fail to display a sensory level. (emcrit.org)
- Grey matter is found within the medial portion of the spinal cord and has two dorsal or posterior horns that contain cell bodies of sensory neurons and two ventral or anterior horns that contain cell bodies of motor neurons. (osmosis.org)
- For this to happen, a first order neuron, found inside a dorsal root ganglion carries sensory input from the skin to the dorsal horn of the spinal cord , where it synapses with the second order neuron. (osmosis.org)
- Depending on its pathogenesis, spinal cord disease can manifest with variable impairment of motor, sensory, or autonomic function. (medscape.com)
Autoimmune diseases2
SACRAL3
- The signal transmitted by the brain is routed through 2 intermediate segments (the brainstem and the sacral spinal cord) prior to reaching the bladder. (medscape.com)
- The lumbar and sacral portions of the cord have 5 segments each. (medscape.com)
- The cauda equina (Latin for horse tail) is the collection of lumbar and sacral spinal nerve roots that travel caudally prior to exiting at their respective intervertebral foramina. (medscape.com)
Arachnoid cyst2
- Preoperative, operative and postoperative radiological examinations and operative notes of 31 patients with spinal arachnoid cyst operated on during 2002-2009 at the Institute of Medical Sciences, Banaras Hindu University, were evaluated. (nih.gov)
- Did you mean intramural spinal arachnoid cyst ? (nih.gov)
Adults2
- Mayo Clinic's spinal tumor experts provide comprehensive care for adults and children with spinal tumors. (mayoclinic.org)
- 2001) compared 422 adults with demyelinating diseases external icon , including MS, and 921 matched controls (people similar in age, gender, and enrollment in a healthcare system, but who did not have demyelinating disease). (cdc.gov)
Intact spinal cord1
- However, a structurally intact spinal cord seen on MR/CT is not equivalent to intact function. (vin.com)
Lesion3
- and vascular spinal cord lesion. (ed.ac.uk)
- Motor weakness may be used to evaluate the level of a spinal lesion that involves the corticospinal tract. (emcrit.org)
- Thus, a central spinal cord lesion may cause neurologic deficits in a descending order. (emcrit.org)
Lesions1
- and lesions in the spinal cord. (ed.ac.uk)
Patients5
- Today, in well-organized spinal cord centers, 94% of patients survive the initial hospitalization. (medscape.com)
- Spinal cord stimulation (SCS) is a promising intervention for FoG in patients with PD, however its effects on distinct domains of postural control is not well known. (elifesciences.org)
- MRI is a noninvasive tool that represents the method of choice for imaging the spinal cord in human patients. (everycat.org)
- Acute Lyme disease, except for the peculiar skin rash it produces in 60 to 80% of the patients in which it occurs, is a summer 'flu-like' illness without a cough. (cdc.gov)
- Patients who do not receive treatment can become completely well, with a possibility of recurrent problems later, or they can develop further problems involving the heart, joints or nervous system as the disease progresses. (cdc.gov)
Neurodegenerative5
- Neurodegenerative diseases of the spinal cord develop mainly in the late old age, but can be congenital and progress throughout life. (doclandmed.com)
- to Treat neurodegenerative diseases of the spinal cord must under the supervision of experienced doctors. (doclandmed.com)
- Neurodegenerative diseases have a profound societal impact and pose significant healthcare costs. (scientificarchives.com)
- Scientists from the University of Bonn, the German Center for Neurodegenerative Diseases and the German Cancer Research Center investigated such peroxisomal diseases on fruit flies. (news-medical.net)
- The neurodegenerative disease affects nerve cells in the brain and spinal cord. (manufacturing.net)
Centers3
Extradural1
- Extradural spinal cord tumors - they are the most malignant. (ucoz.com)
Stroke1
- Spinal stroke - a disease that violates the circulation in the spinal cord. (vsebolezni.com)
Clinical7
- This review focuses on the clinical description of common patterns of spinal cord involvement. (medscape.com)
- Clinical and magnetic resonance imaging findings in 92 cats with clinical signs of spinal cord disease. (everycat.org)
- The most important predictors of an abnormal MRI study were the presence of spinal pain and the severity of clinical signs. (everycat.org)
- Clinical signs of spinal cord tumors are extremely different. (ucoz.com)
- Demographic and clinical data on all people admitted to New Zealand's two spinal units (mid-2007 to mid-2009) were included for the estimate of incidence. (bmj.com)
- Demographic and clinical data on all people (all ages), admitted during the study period to either of New Zealand's two spinal units for the first time following acute impairment, were included for the estimate of incidence. (bmj.com)
- The first five chapters deal with spinal tumors, either primary or metastatic, giving the reader a clear clinical review of the disease and its pathophysiology, as well as therapeutic options. (novapublishers.com)
Diverse pathologic processes1
- Spinal cord disease results from multiple diverse pathologic processes. (medscape.com)
Vertebral3
- The spinal cord is located in the spinal canal, which is formed by the bodies and the vertebral arch. (ucoz.com)
- And that neuron ascends 1-2 vertebral levels and decussates or crosses to the opposite side of the spinal cord via an area of white matter called the anterior white commissure. (osmosis.org)
- The cord ends at vertebral levels L1-L2. (medscape.com)
Thoracic1
- The thoracic cord has 12 segments and provides motor control to the thoracoabdominal musculature. (medscape.com)
Compression3
- The nerve roots exit the spinal canal through a bony tunnel called the neural foramen, and it is at this point, that the nerve roots are especially vulnerable to compression. (ilyasspine.com)
- As in the case with brain tumors, spinal cord tumors is important to not look or structure of the tumor and its location and the compression on certain segments of the brain, it exerts. (ucoz.com)
- Following IV placement, anesthesia, hand bagging to get the radiographs and do a myelogram that should a ruptured C4-5 space and cord compression. (dvm360.com)
Subacute1
- and subacute combined cord affection. (ed.ac.uk)
Canal2
- A CT scan can show the amount of space available for the nerve roots, as well as the space within the neural foramina and spinal canal. (ilyasspine.com)
- However, the spinal cord fills the entire spinal canal is not, and he goes up to 2 - 3 lumbar vertebra. (ucoz.com)
Meningitis3
- Christopher Uejio] C. gattii usually infects the lungs or the central nervous system (the brain and the spinal cord), causing diseases like pneumonia and meningitis, but it can also affect other parts of the body. (cdc.gov)
- Meningitis is an inflammation of the membranes that surround the brain and the spinal cord. (who.int)
- Meningococcal meningitis disease is characterized by high fatality and high frequency. (who.int)
Optic1
- The damage can occur in any part of the brain, optic nerve or spinal cord. (medicinenet.com)
Paraplegia1
- In general, any SCI patient presented with paraplegia/tetraplegia without deep pain perception (DPP), the prognosis for functional recovery is guarded as the "spinal cord function" is completely blocked or transected at the injured site. (vin.com)
Tracts2
- Three major tracts run through the spinal cord, as shown below. (emcrit.org)
- The secondary neuron then ascends up the length of the spinal cord via the spinothalamic tracts , and eventually synapse with a 3rd order neuron located in the ventral posterior nucleus of the thalamus . (osmosis.org)
Shock3
- Loss of autoregulation and spinal shock cause systemic hypotension and exacerbate ischemia. (medscape.com)
- Hypoperfusion of gray matter extends to the surrounding white matter and alters the propagation of action potentials along the axons, contributing to spinal shock. (medscape.com)
- Spinal shock. (medscape.com)
Intervertebral2
- As well, no antemortem studies on the relative frequency of the different etiologies responsible for feline spinal cord disease, such as lymphoma, feline infectious peritonitis, and intervertebral disc disease, exist in the literature. (everycat.org)
- Harris JE, Dhupa S. Lumbosacral intervertebral disk disease in six cats. (everycat.org)
Intradural1
- Intradural - extramedullary spinal tumors. (ucoz.com)
Gait1
- Normal gait, spinal pain only. (vin.com)
Symptom1
- The most characteristic symptom of early Lyme disease is the skin rash which occurs at the site of the tick bite from 5 to 40 or more days after the bite. (cdc.gov)
Tumor1
- Having all this expertise in a single place, focused on you, means that you're not just getting one opinion - your care is discussed among the team, your test results are available quickly, appointments are scheduled in coordination, and the most highly specialized spinal tumor experts in the world are all working together for you. (mayoclinic.org)
Affects1
- Guillain-Barre Syndrome is a severe disease that affects the polarity of the immune system. (vsebolezni.com)