Diseases
Stevens-Johnson Syndrome
Stevens-Johnson Syndrome
Rare cutaneous eruption characterized by extensive KERATINOCYTE apoptosis resulting in skin detachment with mucosal involvement. It is often provoked by the use of drugs (e.g., antibiotics and anticonvulsants) or associated with PNEUMONIA, MYCOPLASMA. It is considered a continuum of Toxic Epidermal Necrolysis.

Epithelial hyperproliferation and transglutaminase 1 gene expression in Stevens-Johnson syndrome conjunctiva. (1/219)

In Stevens-Johnson syndrome, pathological keratinization of the ordinarily nonkeratinized corneal and conjunctival mucosal epithelia results in severe visual loss. We examined conjunctiva covering cornea in five eyes in the chronic cicatricial phase of Stevens-Johnson syndrome. Normal conjunctiva from five age-matched individuals was studied also. The number of epithelial cells in Stevens-Johnson syndrome conjunctiva that were immunoreactive with a monoclonal antibody, Ki-67, to a nuclear antigen found only in proliferating cells was greater than normal (93.8+/-19.8 cells above 100 basal cells versus 12.8+/-0.5 cells above 100 basal cells; P = 0.009). In addition, although clinical inflammation was mild, massive lymphocytic infiltration was seen in the substantia propria of conjunctiva covering cornea. In situ hybridization documented transglutaminase 1 (keratinocyte transglutaminase) mRNA in suprabasal cells of the abnormally thickened conjunctival epithelium in all Stevens-Johnson syndrome patients. In contrast, no message was detected in normal conjunctival or corneal epithelia. Transglutaminase 1 is expressed during the terminal differentiation of keratinocytes where it helps synthesize cornified cell envelopes. We speculate that in Stevens-Johnson syndrome, epithelial hyperproliferation, and transglutaminase 1 gene expression lead to the pathological keratinization of ocular surface mucosal epithelia.  (+info)

Blister fluid T lymphocytes during toxic epidermal necrolysis are functional cytotoxic cells which express human natural killer (NK) inhibitory receptors. (2/219)

Toxic epidermal necrolysis (TEN) is a rare life-threatening adverse drug reaction characterized by a massive destruction of the epidermis. Immunohistological studies of skin biopsies of TEN showed infiltrates of predominantly CD8+ T lymphocytes even though other authors reported a prominent involvement of cells of the monocyte-macrophage lineage. The aim of this study was to characterize phenotypically and functionally the cells present in the cutaneous blister fluid of four patients with TEN. We first determined that lymphocytes were predominant in blister fluid obtained early, while monocytes/macrophages later became the most important population. We then showed that this lymphocyte population, mainly CD3+CD8+, corresponded to a peculiar cell subset as they expressed cutaneous leucocyte antigen, killer inhibitory receptors KIR/KAR and failed to express CD28 molecule. Functionally, we determined that blister T lymphocytes had a cytotoxic T lymphocyte (CTL)- and NK-like cytotoxicity. The role of this cytotoxic lymphocyte population present at the site of lesions during TEN remains to be understood.  (+info)

Nitric oxide synthase in toxic epidermal necrolysis and Stevens-Johnson syndrome. (3/219)

Toxic epidermal necrolysis and Stevens-Johnson syndrome are severe cutaneous drug reactions of unknown mechanism. Nitric oxide can cause apoptosis and necrosis. The inducible form of nitric oxide synthase generates large amounts of nitric oxide and has been described in human skin. We propose that a large burst of nitric oxide in toxic epidermal necrolysis and Stevens-Johnson syndrome may cause the epidermal apoptosis and necrosis. Skin biopsies were taken from seven patients with actively progressing Stevens-Johnson syndrome or toxic epidermal necrolysis. Expression of inducible nitric oxide synthase was examined by reverse transcription-polymerase chain reaction and by immunoperoxidase staining for inducible nitric oxide synthase protein. Messenger RNA for inducible nitric oxide synthase was detected by reverse transcription-polymerase chain reaction and confirmed by the sequencing of polymerase chain reaction products. Strong staining for inducible nitric oxide synthase was observed in inflammatory cells in the lower epidermis and upper dermis. Diffuse, weaker staining was observed in keratinocytes. Expression of inducible nitric oxide synthase is consistent with the hypothesis that nitric oxide mediates the epidermal necrosis in toxic epidermal necrolysis and provides a potential target for therapeutic intervention.  (+info)

SCORTEN: a severity-of-illness score for toxic epidermal necrolysis. (4/219)

The mortality of toxic epidermal necrolysis is about 30%. Our purpose was to develop and validate a specific severity-of-illness score for cases of toxic epidermal necrolysis admitted to a specialized unit and to compare it with the Simplified Acute Physiology Score and a burn scoring system. A sample of 165 patients was used to develop the toxic epidermal necrolysis-specific severity-of-illness score and evaluate the other scores, a sample of 75 for validation. Model development used logistic regression equations that were translated into probability of hospital mortality; validation used measures of calibration and discrimination. We identified seven independent risk factors for death and constituted the toxic epidermal necrolysis-specific severity-of-illness score: age above 40 y, malignancy, tachycardia above 120 per min, initial percentage of epidermal detachment above 10%, serum urea above 10 mmol per liter, serum glucose above 14 mmol per liter, and bicarbonate below 20 mmol per liter. For each toxic epidermal necrolysis-specific severity-of-illness score point the odds ratio was 3.45 (confidence interval 2.26-5.25). Probability of death was: P(death) = elogit/1 + elogit with logit = -4.448 + 1.237 (toxic epidermal nec-rolysis-specific severity-of-illness score). Calibration demonstrated excellent agreement between expected (19. 6%) and actual (20%) mortality; discrimination was also excellent with a receiver operating characteristic area of 82%. The Simplified Acute Physiology Score and the burn score were also associated with mortality. The discriminatory powers were poorer (receiver operating characteristic area: 72 and 75%) and calibration of the Simplified Acute Physiology Score indicated a poor agreement between expected (9.1%) and actual (26.7%) mortality. This study demonstrates that the risk of death of toxic epidermal necrolysis patients can be accurately predicted by the toxic epidermal necrolysis-specific severity-of-illness score. The Simplified Acute Physiology Score and burn score appear to be less adequate.  (+info)

Diagnosis, classification, and management of erythema multiforme and Stevens-Johnson syndrome. (5/219)

BACKGROUND: In adults, erythema multiforme (EM) is thought to be mainly related to herpes infection and Stevens-Johnson syndrome (SJS) to drug reactions. AIMS: To investigate this hypothesis in children, and to review our experience in the management of these patients. METHODS: A retrospective analysis of 77 paediatric cases of EM or SJS admitted to the Children's Hospital in Bordeaux between 1974 and 1998. RESULTS: Thirty five cases, inadequately documented or misdiagnosed mostly as urticarias or non-EM drug reactions were excluded. Among the remaining 42 patients (14 girls and 28 boys), 22 had EM (11 EM minor and 11 EM major), 17 had SJS, and three had isolated mucous membrane involvement and were classified separately. Childhood EM was mostly related to herpes infection and SJS to infectious agents, especially Mycoplasma pneumoniae. Only two cases were firmly attributed to drugs (antibiotics). No patient died. EM and SJS sequelae were minor and steroids were of no overall benefit. CONCLUSION: In paediatric practice EM is frequently misdiagnosed. The proposal that SJS is drug related in adults does not apply to children, and in our recruitment EM and SJS are mostly triggered by infectious agents. The course of both diseases, even though dramatic at onset, leads to low morbidity and mortality when appropriate symptomatic treatment is given.  (+info)

Conjunctival inflammation in the chronic phase of Stevens-Johnson syndrome. (6/219)

AIMS: To understand the immunopathogenesis of the corneal conjunctivalisation in Stevens-Johnson syndrome. METHODS: Conjunctivalised corneas from five patients with Stevens-Johnson syndrome were studied immunohistochemically for several cell surface antigens and two cytokines. Chemical injury specimens were also studied. RESULTS: In all cases, immunohistochemistry revealed LFA-1, CD4, CD8, and CD68 on subepithelial infiltrating cells. Also, HLA-DR and ICAM-1 were found on the surfaces of epithelial cells, subepithelial infiltrating cells, subepithelial fibroblasts, and endothelial cells in blood vessels. IFN-gamma was found in basal epithelial cells; subepithelial cells and subepithelial extracellular matrix CD19 and IL4 were not detected. CONCLUSIONS: The infiltrating cell population in the Stevens-Johnson syndrome samples includes macrophages, CD4 positive T cells, and CD8 positive T cells. The cytokine expression pattern suggests CD4 positive T cells are Th1 cells. The infiltrating cell population is similar in Stevens-Johnson syndrome and chemical injury conjunctivalised corneas.  (+info)

Toxic epidermal necrolysis in a monkey (Macaca fascicularis). (7/219)

An adult male Macaca fascicularis monkey developed toxic epidermal necrolysis after ingestion of methylmercury. The clinical picture was characterized by the development of large cutaneous bullae with subsequent full-thickness epidermal exfoliation. Areas of sparse pelage were most affected, with the most severe exfoliation occurring on the palms, soles, face and ears. Erosions also developed within the oral mucosa and conjunctivae.  (+info)

Patients with acute skin loss: are they best managed on a burns unit? (8/219)

Patients who are critically ill and have large areas of skin loss or breakdown present a difficult management problem. They require the combination of intensive therapy facilities to support failing organs and specialized skin care, sometimes including extensive debridement and reconstruction. The expertise required for both aspects of treatment are found uniquely on a burns unit. We present five patients with large areas of cutaneous loss or damage secondary to a variety of non-burn aetiologies who were managed on a burns unit. We suggest that a burns unit may be the most appropriate place for such patients to be treated during both the acute phase of their illness and the later stages of surgical reconstruction and physical rehabilitation.  (+info)

Stevens-Johnson syndrome (SJS) is a rare, serious cutaneous adverse reaction typically characterized by flu-like symptoms followed by widespread erythema, necrosis and bullous detachment of the epidermis and mucous membranes.

Stevens-Johnson Syndrome (SJS) is a rare, serious and potentially life-threatening skin reaction that usually occurs as a reaction to medication but can also be caused by an infection. SJS is characterized by the detachment of the epidermis (top layer of the skin) from the dermis (the layer underneath). It primarily affects the mucous membranes, such as those lining the eyes, mouth, throat, and genitals, causing painful raw areas that are prone to infection.

SJS is considered a severe form of erythema multiforme (EM), another skin condition, but it's much more serious and can be fatal. The symptoms of SJS include flu-like symptoms such as fever, sore throat, and fatigue, followed by a red or purplish rash that spreads and blisters, eventually leading to the detachment of the top layer of skin.

The exact cause of Stevens-Johnson Syndrome is not always known, but it's often triggered by medications such as antibiotics, anti-convulsants, nonsteroidal anti-inflammatory drugs (NSAIDs), and antiretroviral drugs. Infections caused by herpes simplex virus or Mycoplasma pneumoniae can also trigger SJS.

Treatment for Stevens-Johnson Syndrome typically involves hospitalization, supportive care, wound care, and medication to manage pain and prevent infection. Discontinuing the offending medication is crucial in managing this condition. In severe cases, patients may require treatment in a burn unit or intensive care unit.

Mucous membranesToxicLess than 10LesionsComplicationsCases of Stevens-JohnsonAllopurinolErythema multiformeAtypical pneumoniaSystemic2016EpidermalDiagnosisReactionReactionsManifestationsMedicationsLawsuitInfectionPatientsRashFeverMucosalInvolvement1922InjuryRequires hospitalizationOverlapTreatmentsSeverityMedicalSepsisAffects
Mucous membranes8
  • Mucosal desquamation in a person with Stevens-Johnson syndrome Inflammation and peeling of the lips-with sores presenting on the tongue and the mucous membranes in SJS Conjunctivitis in SJS SJS is thought to arise from a disorder of the immune system. (wikipedia.org)
  • Stevens-Johnson syndrome is a type IV (subtype C) hypersensitivity reaction that typically involves the skin and the mucous membranes. (medscape.com)
  • Typically,Stevens-Johnson syndrome affects the mucous membranes of the oral cavity, nostril, eyes, and both the anal and genital regions. (2keller.com)
  • Stevens-Johnson syndrome is a rare but extremely serious disorder of the skin and mucous membranes. (schmidtandclark.com)
  • Stevens-Johnson Syndrome (SJS) is a rare, serious disorder of the skin and mucous membranes. (torranceasc.com)
  • Stevens-Johnson syndrome is a rare and life-threatening acute allergic reaction aff ecting the skin and mucous membranes. (paedcro.com)
  • Stevens-Johnson syndrome is a result of hypersensitivity reaction in the skin and mucous membranes as a result of immune-complex mediation. (syndromespedia.com)
  • They studied that Stevens-Johnson syndrome has distinct mucous membrane erosion and small blisters on a macula different from EMM with edematous papules with or without the involvement of the mucous membranes. (syndromespedia.com)
Toxic48
  • Together with toxic epidermal necrolysis (TEN) and Stevens-Johnson/toxic epidermal necrolysis (SJS/TEN), it forms a spectrum of disease, with SJS being less severe. (wikipedia.org)
  • It is also included with drug reaction with eosinophilia and systemic symptoms (DRESS syndrome), acute generalized exanthematous pustulosis (AGEP) and toxic epidermal necrolysis in a group of conditions known severe cutaneous adverse reactions (SCARs). (wikipedia.org)
  • NATIENS is a clinical trial for Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis patients in the acute stage. (sjsupport.org)
  • The purpose of the SJS Survivor study is to recruit individuals who have been diagnosed with Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis (SJS/TEN). (sjsupport.org)
  • In some cases, the condition is caused by a bacterial infection, and in many cases there is no known cause for the onset of Stevens-Johnson Syndrome or Toxic Epidermal Necrolysis. (2keller.com)
  • People that have taken or are taking medications such as the ones mentioned above are urged to familiarise themselves with the symptoms of SJS (Stevens-Johnson Syndrome) and Toxic Epidermal Necrolysis (TEN). (2keller.com)
  • If you or a loved one is suffering from Stevens-Johnson Syndrome also known as SJS or Toxic Epidermal Necrolysis, which may be the result of a drug reaction call our Law Firm at 800-862-1260. (carabinshaw.com)
  • Practical guidelines for the treatment and management of Stevens-Johnson syndrome and toxic epidermal necrolysis, rare but life-threatening conditions that are normally caused by drugs or infections. (pharmaceutical-journal.com)
  • Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but severe mucocutaneous conditions, which are often adverse effects of newly started pharmacotherapy. (pharmaceutical-journal.com)
  • If you or a loved one was diagnosed with Stevens-Johnson Syndrome (SJS) or Toxic Epidermal Necrolysis (TEN) after taking Allopurinol, you should contact dangerous drugs law firm immediately. (schmidtandclark.com)
  • Allopurinol is well-known for its association with severe cutaneous adverse reactions including Stevens-Johnson syndrome (SJS) and a more severe form of the condition known as Toxic Epidermal Necrolysis (TEN) . (schmidtandclark.com)
  • Approximately 10% of people with Stevens-Johnson syndrome die from the disease, while the condition is fatal in up to half of those who develop toxic epidermal necrolysis. (schmidtandclark.com)
  • Stevens-Johnson syndrome and toxic epidermal necrolysis are uncommon acute der-matologic disorders. (uwi.edu)
  • The purpose of this study was to examine the frequency, aetiology and outcome of cases of Stevens-Johnson syndrome and toxic epidermal necrolysis admitted to the dermatology ward at the University Hospital of the West Indies. (uwi.edu)
  • This was a retrospective study looking at all patients who were admitted with a diagnosis of Stevens-Johnson syndrome, Stevens-Johnson syndrome/toxic epidermal necrolysis overlap syndrome and toxic epidermal necrolysis over a nine-year period. (uwi.edu)
  • Stevens-Johnson syndrome and toxic epidermal necrolysis contribute significantly to morbidity and mortality of patients on the dermatology ward although mortality was low compared to other studies. (uwi.edu)
  • by Saira B. Momin, DO James Q. Del Rosso, DO, FAOCD Abstract Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare and serious cutaneous adverse reactions. (jcadonline.com)
  • Phenytoin is one of the most common causes of antiepileptic-related cutaneous adverse reactions, including life-threatening Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). (www.gov.uk)
  • Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous adverse drug reactions characterized by different extents of epidermal necrosis and mucosal breakdown. (medicaljournals.se)
  • The dermatologic manifestations of either toxic epidermal necrolysis or Stevens-Johnson syndrome may constitute a true emergency. (medscape.com)
  • Stevens-Johnson syndrome and toxic epidermal necrolysis are thought to be a single disease entity with common causes and mechanisms that is a severe cutaneous adverse reaction differentiated by the severity and extent of skin detachment. (medscape.com)
  • In some cases, Mycoplasma infections may induce Stevens-Johnson syndrome or toxic epidermolysis syndrome, although it may present atypically with no skin lesions and only mucosal involvement, which is known as Fuchs syndrome. (medscape.com)
  • [ 3 ] The mortality rate associated with Stevens-Johnson syndrome is much lower than the rate associated with toxic epidermal necrolysis, approaching 5% of cases. (medscape.com)
  • Together, Stevens-Johnson syndrome and toxic epidermal necrolysis may represent a spectrum of a single disease process. (medscape.com)
  • The initial skin lesions of Stevens-Johnson syndrome/toxic epidermal necrolysis are poorly defined, erythematous macules with darker, purpuric centers. (medscape.com)
  • Steven Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN) are dermatologic emergencies that are more likely to be encountered by primary care providers rather than dermatologists. (ku.edu)
  • Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare and serious cutaneous adverse reactions. (jcadonline.com)
  • Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare, but serious and potentially life-threatening adverse cutaneous reactions commonly associated with the use of specific medications. (jcadonline.com)
  • Stevens-Johnson syndrome and toxic epidermal necrolysis are severe cutaneous hypersensitivity reactions. (msdmanuals.com)
  • Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are clinically similar except for their distribution. (msdmanuals.com)
  • Formerly known as Lyell sickness, SJS (Stevens-Johnson syndrome), TEN (toxic epidermal necrolysis), and erythema multiform primary staphylococcal scalded epidermal syndrome- are different manifestations of the same illness. (medtigo.com)
  • It is estimated that 2 to 7 persons per million experience Stevens-Johnson syndrome/toxic epidermal necrolysis each year. (medtigo.com)
  • 3 times more people experience Stevens-Johnson syndrome than toxic epidermal necrolysis. (medtigo.com)
  • There have been many reports of medicines causing Stevens-Johnson syndrome or toxic epidermal necrolysis. (medtigo.com)
  • SJS Canada's vision is to facilitate an umbrella of services for the SJS/TEN patient community in Canada, through health promotion by providing people suffering from Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis (SJS/TEN), their families, and caregivers with access to related counseling, education, support groups, and information programs. (skinpatientalliance.ca)
  • Stevens-Johnson syndrome can be seen as a mild form of TEN or toxic epidermal necrolysis. (syndromespedia.com)
  • Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN) are both life-threatening skin reactions that can result in death. (thelyonfirm.com)
  • If it is not diagnosed and treated in a timely manner, Stevens Johnson Syndrome can take a more severe form, known as Toxic Epidermal Necrolysis. (arfaalawgroup.com)
  • Steven-Johnsons Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are very unpredictable and sudden illnesses that are typically a reaction to a medication, an infection, or both. (thelakelawfirm.com)
  • Did you or a loved one endure Stevens-Johnsons Syndrome or Toxic Epidermal Necrolysis? (thelakelawfirm.com)
  • Reach out today to learn more about how The Lake Law Firm can help you with a Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis lawsuit. (thelakelawfirm.com)
  • Our law firm is currently handling lawsuits on behalf of individuals diagnosed with Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis (SJS/TEN). (thelakelawfirm.com)
  • What Do We Know about Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Lawsuits? (thelakelawfirm.com)
  • Stevens Johnson syndrome (SJS) and the more severe variant of the disease, toxic epidermal necrolysis syndrome (TENS), are intense autoimmune sensitivity reactions to infections or medications that primarily affect the skin and mucus membranes, including the eyes. (scleralcontacts.org)
  • Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) represent opposite ends of a spectrum of disease that results from an adverse reaction, most often to certain medications. (rarediseases.org)
  • The term toxic epidermal necrolysis was introduced in the medical literature in 1956 by Dr. A. Lyell and is also known as Lyell syndrome. (rarediseases.org)
  • The overall objective of the guidelines is to provide up-to-date, evidence-based recommendations for the diagnosis and management of the full spectrum of Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and SJS-TEN overlap in adults during the acute phase of the disease. (posticu.org)
  • Oxcarbazepine may cause serious, life-threatening dermatologic reactions including Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). (medicinenet.com)
Less than 101
  • The diagnosis of Stevens-Johnson syndrome is based on involvement of less than 10% of the skin. (wikipedia.org)
Lesions4
  • Diagnosis is usually obvious by appearance of initial lesions and clinical syndrome. (msdmanuals.com)
  • However, the characteristic lesions of Stevens-Johnson syndrome were different so the former was ruled out. (syndromespedia.com)
  • The Stevens-Johnson syndrome (SJS) is a variant of erythema multiforme by the conformation and distribution of skin lesions and more severe mucosal involvement. (bvsalud.org)
  • Steven-Johnson syndrome is a common condition characterised by erythematous target lesions on the skin and involvement of the oral mucosa, genitals and conjunctivae. (ox.ac.uk)
Complications1
  • Dr. Irwin Azman prescribes PVR PROSE Lenses for a variety of hard-to-fit eyes, including patients with Stevens-Johnson Syndrome, Radial Keratotomy (RK) and Lasik Complications, Keratoconus, Corneal Ectasia, Post-Surgical Vision Loss, and Pellucid Marginal Degeneration. (scleralcontacts.org)
Cases of Stevens-Johnson3
  • Most cases of Stevens-Johnson syndrome must be treated in a hospital, often in an intensive care unit (ICU). (schmidtandclark.com)
  • We have treated and documented some cases of Stevens - Johnson syndrome. (homeodoctor.co.in)
  • We would like to undertake and study more cases of Stevens - Johnson syndrome. (homeodoctor.co.in)
Allopurinol3
  • Allopurinol, a prescription medication used to treat gout and prevent kidney stones, has recently been linked to an increased risk for the development of Stevens-Johnson Syndrome (SJS), a rare but severe skin condition that causes a painful rash that spreads and blisters. (schmidtandclark.com)
  • You may be entitled to obtain compensation for medical bills by filing an Allopurinol Stevens-Johnson Syndrome Lawsuit and our lawyers can help. (schmidtandclark.com)
  • If the physician determines that Stevens-Johnson syndrome is being caused by Allopurinol or another medication you're taking, the medicine will be discontinued immediately for a drug with less severe side effects. (schmidtandclark.com)
Erythema multiforme2
  • Stevens-Johnson syndrome may also have features of the dermatologic condition erythema multiforme (which has led to confusion in nosology). (medscape.com)
  • Erythema multiforme major (EMM) was synonymously considered Stevens-Johnson syndrome. (syndromespedia.com)
Atypical pneumonia1
  • She was diagnosed with Stevens-Johnson syndrome following atypical pneumonia caused by Mycoplasma pneumoniae with microbiological and pathological confirmation. (archbronconeumol.org)
Systemic3
  • Autoimmune disease was present in 6 patients: Sjögren's syndrome or Sjögren-like syndrome in 5 patients and concomitant systemic lupus erythematosus and Hashimoto thyroiditis in one patient. (medicaljournals.se)
  • Recurrent Stevens-Johnson syndrome in a patient with systemic lupus erythematosus: a case report. (ouhsc.edu)
  • Stevens-Johnson Syndrome eventually leads to a systemic condition that has high rates of mortality. (syndromespedia.com)
20161
  • 2016. https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307702/all/Stevens���������johnson_Syndrome. (unboundmedicine.com)
Epidermal1
  • Stevens-Johnson syndrome and TEN is classified under exanthematic necrolysis or acute disseminated epidermal necrosis with different severity, Stevens-Johnson syndrome as the milder form. (syndromespedia.com)
Diagnosis2
  • We can investigate your Stevens Johnson Syndrome to determine whether medical malpractice played a role in a delayed or inaccurate diagnosis or treatment. (arfaalawgroup.com)
  • Knowledge of this syndrome, the dentist is crucial, since the establishment of early diagnosis can minimize sequelae and even prevent extreme cases death. (bvsalud.org)
Reaction11
  • Stevens-Johnson syndrome (SJS) is a type of severe skin reaction. (wikipedia.org)
  • A case study links the glaucoma drug Neptazane with a case of Stevens-Johnson Syndrome, a serious skin reaction which can lead to severe injury, hospitalization and death. (aboutlawsuits.com)
  • The multiple myeloma drug Velcade was linked to a potentially deadly skin reaction known as Stevens-Johnson Syndrome in a recent case report from Korea. (aboutlawsuits.com)
  • Stevens-Johnson Syndrome is a potentially deadly skin disease that usually results from a drug reaction. (2keller.com)
  • Stevens-Johnson Syndrome (SJS) is a serious and potentially life-threatening skin reaction. (goldenberglaw.com)
  • Stevens-Johnson Syndrome is a severe skin reaction often triggered by certain over the counter and prescription medications. (vlaw.com)
  • Stevens-Johnson syndrome starts from a delayed hypersensitivity reaction as a result of slow acetylators resulting from a dysfunction in the liver. (syndromespedia.com)
  • Normal doses of Tylenol (acetaminophen) are associated with a rare but life-threatening skin reaction called Stevens-Johnson Syndrome (SJS). (theclarkfirmtexas.com)
  • Stevens-Johnson Syndrome (SJS) is a hypersensitive skin reaction that can result in death. (theclarkfirmtexas.com)
  • Epifania Malakaya has been BEDRIDDEN for 3 months already due to STEVEN JOHNSON SYNDROME which is a potentially DEADLY SKIN DISEASE that usually results from a drug reaction. (quantuminplusonline.net)
  • Stevens-Johnson syndrome is a rare and unpredictable reaction. (soundhealthdoctor.com)
Reactions8
  • A new study calls for more accurate testing for drugs which may be linked to Stevens-Johnson Syndrome skin reactions. (aboutlawsuits.com)
  • A new study finds that antibiotics are the type of drug most associated with potentially deadly skin reactions known as Stevens-Johnson Syndrome. (aboutlawsuits.com)
  • A new study identifies antibiotics, anticonvulsants as NSAIDs as the drugs most commonly linked to Stevens-Johnson Syndrome skin reactions. (aboutlawsuits.com)
  • Hypersensitivity reactions from medications have been studied to cause Stevens-Johnson syndrome. (syndromespedia.com)
  • Steven-Johnsons Syndrome (SJS) is a rare but life-threatening skin disorder caused by adverse reactions to certain drugs. (thelakelawfirm.com)
  • July 31, 2013 - The U.S. Food and Drug Administration (FDA) has published a Drug Safety Communication to warn that normal doses of Tylenol (acetaminophen) are associated with rare but life-threatening skin reactions, including Stevens-Johnson Syndrome (SJS) . (theclarkfirmtexas.com)
  • Briefing journalists in Abuja, on Friday, Professor Adewole said the health condition known as Stevens Johnson Syndrome (SJS) was an unusual allergic reactions in Nigeria and some parts of Europe. (soundhealthdoctor.com)
  • Unfavorable medication reactions like Stevens-Johnson syndrome (SJS) have the potential to be fatal. (ajphs.com)
Manifestations1
  • The actual clinical manifestations of a vesicant exposure may be more variable than the syndrome described above. (cdc.gov)
Medications4
  • What Medications Cause Stevens-Johnson Syndrome? (goldenberglaw.com)
  • HIV infection also intensifies Stevens-Johnson syndrome caused by medications. (syndromespedia.com)
  • Stevens-Johnson Syndrome ( SJS ) is a skin disorder associated with the use of a variety of medications, including Ibuprofen, SJS , which have the active ingredient of acetaminophen. (thelyonfirm.com)
  • Patients who developed Stevens-Johnson Syndrome may have claims against the manufacturers of certain medications or medical professionals after experiencing rashes and blisters that can lead to severe injury or death. (thelakelawfirm.com)
Lawsuit2
Infection3
  • The exposed skin is highly-susceptible to infection, which is the most common cause of death from Stevens-Johnson Syndrome. (theclarkfirmtexas.com)
  • Treatment of Steven-Johnson syndrome remains supportive along with treating the underlying infection if recognised. (ox.ac.uk)
  • For efforts for T. vaginalis infection have traditionally lagged far symptomatic men, the most common syndrome is urethri- behind efforts to control other STIs. (cdc.gov)
Patients6
  • Minimal dermal inflammatory cell infiltrate and full-thickness necrosis of the epidermis are typical histopathologic findings in patients with Stevens-Johnson syndrome. (medscape.com)
  • Most patients with Stevens-Johnson syndrome are treated symptomatically. (medscape.com)
  • At Arfaa Law Group, our seasoned Baltimore medical malpractice attorneys have extensive experience representing patients in lawsuits involving many complex conditions and syndromes. (arfaalawgroup.com)
  • Patients with Stevens-Johnson Syndrome have a tendency to have ocular difficulties including dry eyes, eye pain, light sensitivity, scarring, and corneal erosion. (scleralcontacts.org)
  • A new option for treatment of severe cicatricial entropion in patients with Stevens-Johnson syndrome. (bvsalud.org)
  • Calcium folinate rescue has to be performed by parenteral administration in patients with malabsorption syndromes or other gastrointestinal disorders where enteral absorption is not assured. (janusinfo.se)
Rash3
  • It is unknown exactly how many adults contract Stevens Johnson Syndrome after using lamotrigine, but the German Rash Registry suggests that it occurs in 0.02 percent of adults. (mishkindlaw.com)
  • Often, Stevens-Johnson syndrome begins with flu-like symptoms, followed by a painful red or purplish rash that spreads and blisters. (soundhealthdoctor.com)
  • Recently, there has been several documentation of an incomplete presentation of this syndrome-without the typical rash but with mucosal, conjunctival and genital involvement. (ox.ac.uk)
Fever2
  • Stevens-Johnson syndrome is characterized by generalized exanthema associated with high fever, catarrhal symptoms and mucositis. (archbronconeumol.org)
  • These open sores and fever were early indicators of Stevens Johnson Syndrome (SJS). (mishkindlaw.com)
Mucosal1
  • Our case illustrates that the incomplete Steven-Johnson syndrome may present with oral mucosal and conjunctival involvement alone without skin or genital involvement. (ox.ac.uk)
Involvement1
  • A patient with severe eye involvement associated with Stevens-Johnson syndrome. (medscape.com)
19222
  • Stevens-Johnson syndrome was named after two American pediatricians in 1922, Albert Stevens and Frank Johnson. (syndromespedia.com)
  • SJS was first described in the medical literature in 1922 by doctors A.M. Stevens and F.C. Johnson. (rarediseases.org)
Injury1
  • If you believe that you or someone close to you developed Stevens Johnson Syndrome due to a medical professional's negligence, you should immediately contact an injury attorney who can help. (arfaalawgroup.com)
Requires hospitalization2
  • Stevens-Johnson syndrome is a medical emergency that requires hospitalization in most cases. (schmidtandclark.com)
  • Stevens-Johnson syndrome is a medical emergency that usually requires hospitalization. (soundhealthdoctor.com)
Overlap1
  • The term SJS/TEN-overlap syndrome is used to describe cases in which 10%-30% of the body surface area is detached. (rarediseases.org)
Treatments1
  • A new Chinese study found glucocorticoids are effective treatments for Stevens-Johnson Syndrome. (aboutlawsuits.com)
Severity1
  • Recovery after Stevens-Johnson syndrome can take weeks to months, depending on the severity of your condition. (soundhealthdoctor.com)
Medical4
  • There have been reports in the medical literature of Stevens-Johnson syndrome associated with the administration of this medication. (schmidtandclark.com)
  • Stevens-Johnson Syndrome" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ouhsc.edu)
  • If you or a loved one has suffered from Stevens Johnson Syndrome (SJS) due to a medical professional's negligence, you may be able to recover compensation through a medical malpractice claim. (arfaalawgroup.com)
  • If you suspect you have Stevens-Johnson syndrome, it's vital that you seek medical help right away as it can be life-threatening. (activebeat.com)
Sepsis1
  • The findings of a new study indicate those with diabetes face a higher risk of sepsis, death and other risks from Stevens-Johnson Syndrome. (aboutlawsuits.com)
Affects2

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