Stiff-Person Syndrome
Glutamate Decarboxylase
Abdominal Muscles
Lordosis
Encyclopedias as Topic
Cerebellar Ataxia
Stiff-man syndrome: from the bedside to the bench. (1/65)
The study of SMS, a rare disease, has resulted in a better understanding of a more common disorder, IDDM, and has allowed investigators to gain insights into the molecular mechanisms of autoimmunity. Many unanswered questions remain, such as the specific site of disease activity in SMS, both at the bedside (cortex, brain stem, or spinal cord) and at the bench (neuronal cytoplasma or synapse). The association of SMS with neoplastic disease and the development of autonomicdysfunction are not understood. The next decade may provide answers to these puzzling issues. (+info)Autoimmunity to gephyrin in Stiff-Man syndrome. (2/65)
Stiff-Man syndrome (SMS) is a rare disease of the central nervous system (CNS) characterized by chronic rigidity, spasms, and autoimmunity directed against synaptic antigens, most often the GABA-synthesizing enzyme glutamic acid decarboxylase (GAD). In a subset of cases, SMS has an autoimmune paraneoplastic origin. We report here the identification of high-titer autoantibodies directed against gephyrin in a patient with clinical features of SMS and mediastinal cancer. Gephyrin is a cytosolic protein selectively concentrated at the postsynaptic membrane of inhibitory synapses, where it is associated with GABA(A) and glycine receptors. Our findings provide new evidence for a close link between autoimmunity directed against components of inhibitory synapses and neurological conditions characterized by chronic rigidity and spasms. (+info)Motor cortex excitability in stiff-person syndrome. (3/65)
Muscle stiffness in stiff-person syndrome (SPS) is produced by continuous, involuntary firing of motor units that is thought to be caused by an autoimmune mediated dysfunction of GABA-ergic inhibitory neurones. We have postulated that the loss of GABA-ergic inputs from spinal interneurones alone is insufficient to produce tonic firing of motor neurones and that excessive supraspinal excitation could also play a role. To determine whether SPS is associated with dysfunction in supraspinal GABA-ergic neurones, we assessed the excitability of the motor cortex with transcranial magnetic stimulation (TMS) in seven SPS patients and seven age-matched healthy volunteers. SPS patients had normal central motor conduction times, normal thresholds for motor evoked potentials (MEPs) in leg muscles, and a normal MEP stimulus versus response recruitment curve with increasing TMS intensities in resting hand and leg muscles. Cortical silent periods were shortened in leg muscles. Intracortical inhibition and excitation were assessed while recording from the abductor pollicis brevis, using a paired pulse TMS paradigm with subthreshold conditioning stimuli. Patients had decreased inhibition and markedly increased facilitation at short intervals. Using paired suprathreshold TMS, patients exhibited increased facilitation at 20- and 40-ms intervals. These results point to a hyperexcitability of the motor cortex in SPS, which could be explained by impairment of supraspinal GABA-ergic neurones, leading to an impaired balance between inhibitory and excitatory intracortical circuitry. (+info)Stiff-person syndrome associated with cerebellar ataxia and high glutamic acid decarboxylase antibody titer. (4/65)
Glutamic acid decarboxylase (GAD) is the main target of humoral autoimmunity in patients with insulin-dependent diabetes mellitus (IDDM) and stiff-person syndrome. We reviewed the case of a 46-year-old woman who had cerebellar ataxia before getting stiff-person syndrome and IDDM with high anti-GAD autoantibody titers. This was a rare case in which there were both the clinical symptoms of stiff-person syndrome and cerebellar ataxia. In western blot analysis her serum reacted with 65-kDa proteins from rat cerebellum, cerebral cortex, and spinal cord. Autoantibodies to GAD may cause functional impairment of gamma-aminobutyric acid (GABA) neurons in the spinal cord as well as in the cerebellum. (+info)High-dose intravenous immune globulin for stiff-person syndrome. (5/65)
BACKGROUND: Stiff-person syndrome is a disabling central nervous system disorder with no satisfactory treatment that is characterized by muscle rigidity, episodic muscle spasms, high titers of antibodies against glutamic acid decarboxylase (GAD65), and a frequent association with autoimmune disorders. Because stiff-person syndrome is most likely immune-mediated, we evaluated the efficacy of intravenous immune globulin. METHODS: We assigned 16 patients who had stiff-person syndrome and anti-GAD65 antibodies, in random order, to receive intravenous immune globulin or placebo for three months, followed by a one-month washout period and then by three months of therapy with the alternative agent. Efficacy was judged by improvements in scores on the distribution-of-stiffness index and heightened-sensitivity scale from base line (month 1) to the second and third month of each treatment phase. Direct and carryover effects of treatment were compared in the two groups. RESULTS: Among patients who received immune globulin first, stiffness scores decreased significantly (P=0.02) and heightened-sensitivity scores decreased substantially during immune globulin therapy but rebounded during placebo administration. In contrast, the scores in the group that received placebo first remained constant during placebo administration but dropped significantly during immune globulin therapy (P=0.01). When the data were analyzed for a direct and a first-order carryover effect, there was a significant difference in stiffness scores (P=0.01 and P<0.001, respectively) between the immune globulin and placebo groups, and immune globulin therapy had a significant direct treatment effect on sensitivity scores (P=0.03). Eleven patients who received immune globulin became able to walk more easily or without assistance, their frequency of falls decreased, and they were able to perform work-related or household tasks. The duration of the beneficial effects of immune globulin varied from six weeks to one year. Anti-GAD65 antibody titers declined after immune globulin therapy but not after placebo administration. CONCLUSIONS: Intravenous immune globulin is a well-tolerated and effective, albeit costly, therapy for patients with stiff-person syndrome and anti-GAD65 antibodies. (+info)Intravenous immunoglobulin in neurological disease: a specialist review. (6/65)
Treatment of neurological disorders with intravenous immunoglobulin (IVIg) is an increasing feature of our practice for an expanding range of indications. For some there is evidence of benefit from randomised controlled trials, whereas for others evidence is anecdotal. The relative rarity of some of the disorders means that good randomised control trials will be difficult to deliver. Meanwhile, the treatment is costly and pressure to "do something" in often distressing disorders considerable. This review follows a 1 day meeting of the authors in November 2000 and examines current evidence for the use of IVIg in neurological conditions and comments on mechanisms of action, delivery, safety and tolerability, and health economic issues. Evidence of efficacy has been classified into levels for healthcare interventions (tables 1 and 2). (+info)Stiff person syndrome and myasthenia gravis. (7/65)
Association of stiff person syndrome, an immune related disorder of anterior horn cells and myasthenia gravis an endplate disorder with similar pathogenesis, is rare. This communication documents this association in the Indian literature for the first time. (+info)T-cell reactivity to glutamic acid decarboxylase in stiff-man syndrome and cerebellar ataxia associated with polyendocrine autoimmunity. (8/65)
Antibodies to glutamic acid decarboxilase (GAD-Abs) are present in the serum of 60-80% of newly diagnosed type 1 diabetes (DM1) patients and patients with autoimmune polyendocrine syndrome (APS) associated with DM1. Higher titre of GAD-Abs are also present in the serum of 60% of patients with stiff-man syndrome (SMS) and all reported patients with cerebellar ataxia associated with polyendocrine autoimmunity (CAPA). Several studies suggest that GAD-Abs may play a critical role in the pathogenesis of SMS and CAPA but little is known about T-cell responsiveness to GAD-65 in these neurological diseases. To analyse cell-mediated responses to GAD, we studied the peripheral blood lymphocyte proliferation and cytokine responses to recombinant human GAD-65 in 5 patients with SMS, 6 with CAPA, 9 with DM1, 8 with APS and 15 control subjects. GAD-65-specific cellular proliferation was significantly higher in SMS than in CAPA, DM1, APS or controls. In contrast, only T cells from CAPA patients showed a significantly high production of interferon-gamma after GAD stimulation, compared to all other patients and controls. No differences were found for IL-4 production. These results suggest that, despite similar humoral autoreactivity, cellular responses to GAD are different between SMS and CAPA, with a greater inflammatory response in CAPA, and this difference may be relevant to the pathogenesis of these diseases. (+info)Stiff-Person Syndrome (SPS) is a rare neurological disorder characterized by fluctuating muscle rigidity in the trunk and limbs and a heightened sensitivity to stimuli such as touch, sound, and emotional distress, which can trigger muscle spasms. The symptoms can significantly affect a person's ability to perform daily activities and can lead to frequent falls and injuries. SPS is often associated with antibodies against glutamic acid decarboxylase (GAD), an enzyme involved in the production of a neurotransmitter called gamma-aminobutyric acid (GABA) that helps regulate muscle movement. The exact cause of SPS remains unknown, but it is thought to involve both autoimmune and genetic factors.
Glutamate decarboxylase (GAD) is an enzyme that plays a crucial role in the synthesis of the neurotransmitter gamma-aminobutyric acid (GABA) in the brain. GABA is an inhibitory neurotransmitter that helps to balance the excitatory effects of glutamate, another neurotransmitter.
Glutamate decarboxylase catalyzes the conversion of glutamate to GABA by removing a carboxyl group from the glutamate molecule. This reaction occurs in two steps, with the enzyme first converting glutamate to glutamic acid semialdehyde and then converting that intermediate product to GABA.
There are two major isoforms of glutamate decarboxylase, GAD65 and GAD67, which differ in their molecular weight, subcellular localization, and function. GAD65 is primarily responsible for the synthesis of GABA in neuronal synapses, while GAD67 is responsible for the synthesis of GABA in the cell body and dendrites of neurons.
Glutamate decarboxylase is an important target for research in neurology and psychiatry because dysregulation of GABAergic neurotransmission has been implicated in a variety of neurological and psychiatric disorders, including epilepsy, anxiety, depression, and schizophrenia.
A syndrome, in medical terms, is a set of symptoms that collectively indicate or characterize a disease, disorder, or underlying pathological process. It's essentially a collection of signs and/or symptoms that frequently occur together and can suggest a particular cause or condition, even though the exact physiological mechanisms might not be fully understood.
For example, Down syndrome is characterized by specific physical features, cognitive delays, and other developmental issues resulting from an extra copy of chromosome 21. Similarly, metabolic syndromes like diabetes mellitus type 2 involve a group of risk factors such as obesity, high blood pressure, high blood sugar, and abnormal cholesterol or triglyceride levels that collectively increase the risk of heart disease, stroke, and diabetes.
It's important to note that a syndrome is not a specific diagnosis; rather, it's a pattern of symptoms that can help guide further diagnostic evaluation and management.
The abdominal muscles, also known as the abdominals or abs, are a group of muscles in the anterior (front) wall of the abdominopelvic cavity. They play a crucial role in maintaining posture, supporting the trunk, and facilitating movement of the torso. The main abdominal muscles include:
1. Rectus Abdominis: These are the pair of long, flat muscles that run vertically along the middle of the anterior abdominal wall. They are often referred to as the "six-pack" muscles due to their visible, segmented appearance in well-trained individuals. The primary function of the rectus abdominis is to flex the spine, allowing for actions such as sitting up from a lying down position or performing a crunch exercise.
2. External Obliques: These are the largest and most superficial of the oblique muscles, located on the lateral (side) aspects of the abdominal wall. They run diagonally downward and forward from the lower ribs to the iliac crest (the upper part of the pelvis) and the pubic tubercle (a bony prominence at the front of the pelvis). The external obliques help rotate and flex the trunk, as well as assist in side-bending and exhalation.
3. Internal Obliques: These muscles lie deep to the external obliques and run diagonally downward and backward from the lower ribs to the iliac crest, pubic tubercle, and linea alba (the strong band of connective tissue that runs vertically along the midline of the abdomen). The internal obliques help rotate and flex the trunk, as well as assist in forced exhalation and increasing intra-abdominal pressure during actions such as coughing or lifting heavy objects.
4. Transversus Abdominis: This is the deepest of the abdominal muscles, located inner to both the internal obliques and the rectus sheath (a strong, fibrous covering that surrounds the rectus abdominis). The transversus abdominis runs horizontally around the abdomen, attaching to the lower six ribs, the thoracolumbar fascia (a broad sheet of connective tissue spanning from the lower back to the pelvis), and the pubic crest (the front part of the pelvic bone). The transversus abdominis helps maintain core stability by compressing the abdominal contents and increasing intra-abdominal pressure.
Together, these muscles form the muscular "corset" of the abdomen, providing support, stability, and flexibility to the trunk. They also play a crucial role in respiration, posture, and various movements such as bending, twisting, and lifting.
Lordosis is a term used in the medical field to describe an excessive inward curvature of the spine. It most commonly occurs in the cervical (neck) and lumbar (lower back) regions. When it happens in the lower back, it's often referred to as swayback. While some degree of lordosis is normal and necessary for proper spinal alignment and movement, excessive curvature can lead to pain, discomfort, and difficulty with mobility. It can be caused by a variety of factors, including poor posture, obesity, pregnancy, and certain medical conditions such as kyphosis or spondylolisthesis.
An encyclopedia is a comprehensive reference work containing articles on various topics, usually arranged in alphabetical order. In the context of medicine, a medical encyclopedia is a collection of articles that provide information about a wide range of medical topics, including diseases and conditions, treatments, tests, procedures, and anatomy and physiology. Medical encyclopedias may be published in print or electronic formats and are often used as a starting point for researching medical topics. They can provide reliable and accurate information on medical subjects, making them useful resources for healthcare professionals, students, and patients alike. Some well-known examples of medical encyclopedias include the Merck Manual and the Stedman's Medical Dictionary.
Cerebellar ataxia is a type of ataxia, which refers to a group of disorders that cause difficulties with coordination and movement. Cerebellar ataxia specifically involves the cerebellum, which is the part of the brain responsible for maintaining balance, coordinating muscle movements, and regulating speech and eye movements.
The symptoms of cerebellar ataxia may include:
* Unsteady gait or difficulty walking
* Poor coordination of limb movements
* Tremors or shakiness, especially in the hands
* Slurred or irregular speech
* Abnormal eye movements, such as nystagmus (rapid, involuntary movement of the eyes)
* Difficulty with fine motor tasks, such as writing or buttoning a shirt
Cerebellar ataxia can be caused by a variety of underlying conditions, including:
* Genetic disorders, such as spinocerebellar ataxia or Friedreich's ataxia
* Brain injury or trauma
* Stroke or brain hemorrhage
* Infections, such as meningitis or encephalitis
* Exposure to toxins, such as alcohol or certain medications
* Tumors or other growths in the brain
Treatment for cerebellar ataxia depends on the underlying cause. In some cases, there may be no cure, and treatment is focused on managing symptoms and improving quality of life. Physical therapy, occupational therapy, and speech therapy can help improve coordination, balance, and communication skills. Medications may also be used to treat specific symptoms, such as tremors or muscle spasticity. In some cases, surgery may be recommended to remove tumors or repair damage to the brain.
Autoantibodies are defined as antibodies that are produced by the immune system and target the body's own cells, tissues, or organs. These antibodies mistakenly identify certain proteins or molecules in the body as foreign invaders and attack them, leading to an autoimmune response. Autoantibodies can be found in various autoimmune diseases such as rheumatoid arthritis, lupus, and thyroiditis. The presence of autoantibodies can also be used as a diagnostic marker for certain conditions.
Stiff-person syndrome
List of autoimmune diseases
Pseudoathletic appearance
Celine Dion
Satoyoshi syndrome
Fear of crossing streets
Glycine receptor
Catatonia
Glutamate decarboxylase
GAD2
Encephalomyelitis
Autoimmune encephalitis
Hyperekplexia
Courage World Tour
Gephyrin
Diazepam
Amphiphysin
Glycine receptor, alpha 1
Love Again (soundtrack)
Love Again (Celine Dion song)
Thymoma
Immunoglobulin therapy
I'll Be (Celine Dion song)
Glutamic acid
SPS
Jacqui Kapinowski
Myotonia congenita
List of MeSH codes (C20)
Scheie syndrome
List of syndromes
Stiff-person syndrome - Wikipedia
Stiff Person Syndrome: Practice Essentials, Background, Pathophysiology
Celine Dion Suffered More Issues Aside From Stiff-Person Syndrome
Stiff Person Syndrome
Celine Dion Made a Rare Public Appearance Amid Stiff-Person Syndrome Diagnosis
Céline Dion's Sister Says She's 'Strong' amid Stiff Person Syndrome Battle: 'Doing Everything to Recover'
One in a Million Odds: Living with Stiff Person Syndrome - Rare Disease Day 2023
Tara Zier - Stiff Person Syndrome Research Foundation and Finding Your Purpose - MitoAction
Celine Dion 'can barely move' as she sells home amid Stiff Person Syndrome battle - Smooth
Celine Dion Has Stiff Person Syndrome, Cancels Tour Dates
Celine Dion stiff person syndrome - Search News
Stiff-Person Syndrome - Brain, Spinal Cord, and Nerve Disorders - MSD Manual Consumer Version
Celine Dion stiff person syndrome - Bing News
Stiff person syndrome | Practical Neurology
stiff person syndrome - CSI Pharmacy
Stiff Person Syndrome - Living Forward
Bad Tad, MD » Stiff-Person Syndrome
Celine Dion stiff person syndrome - Search News
Celine Dion stiff person syndrome - Bing News
Celine Dion stiff person syndrome - Bing News
Celine Dion stiff person syndrome - Bing News
Celine Dion stiff person syndrome - Bing News
Celine Dion stiff person syndrome - Search News
Celine Dion Stiff Person Syndrome Health Update
Celine Dion stiff person syndrome - Bing News
Stiff Person Syndrome - Symptoms, Treatment, Prognosis, Causes
Celine Dion stiff person syndrome - Search Maps
Celine Dion stiff person syndrome - Search Maps
Celine Dion stiff person syndrome - Search News
20234
- The family of Grammy-winning singer Celine Dion revealed in late summer 2023 that she was dying following her diagnosis of stiff-person syndrome. (bing.com)
- Celine Dion's well-being in 2023: Battling Stiff Person Syndrome and other obstacles? (mylucena.com)
- Earlier this year, Dion announced that she would push back her planned 2022 tour until 2023, People reports. (bestlifeonline.com)
- Pop superstar Celine Dion's announcement that she was canceling her 2023 tour due to a diagnosis of stiff person syndrome (SPS) has focused the spotlight on this extremely rare autoimmune neurologic disorder. (utswmed.org)
Dion's7
- Celine Dion's (pic) loved ones are rallying for the global superstar as she lives with stiff-person syndrome, a rare neurological disorder. (bing.com)
- Celine Dion's Family Reveals She Is Dying of Stiff-Person Syndrome? (bing.com)
- Celine Dion's sister, Claudette, is letting fans know the singer is working hard to get back her strength amid her battle with Stiff Person Syndrome. (bing.com)
- Celine Dion's sister has opened up about the singer's battle Stiff Person Syndrome. (bing.com)
- Céline Dion's sister Claudette has shared an update on the singer's health nearly eight months after she revealed she was diagnosed with stiff person syndrome. (nbcbayarea.com)
- Céline Dion's sister, Claudette Dion, told Le Journal de Montreal via SheMazing, that the Grammy winner is not letting her stiff person syndrome diagnosis slow her down too much. (nbcbayarea.com)
- December 2022 - Entertainment Tonight, hosted by Nischelle Turner and Kevin Fischer, break down Celine Dion's disclosure of her SPS diagnosis, including an interview with The Stiff Person Syndrome Research Foundation Founder and President, Tara Zier. (stiffperson.org)
20228
- On December 8, 2022, she left everyone shocked and heartbroken as she confirmed that she was officially diagnosed with a rare neurological disorder, Stiff-person syndrome . (okmagazine.com)
- The performer, 55, revealed in December 2022 that she was battling a rare neurological disorder named Stiff Person Syndrome. (smoothradio.com)
- March 2022 - A thoughtful interview about invisible disabilities that we hope will help the next person get a proper diagnosis, find good doctors, and discover new purpose. (stiffperson.org)
- That was the case for Stiff Person Syndrome (SPS), a relatively unknown neurological condition until global recording star Celine Dion cancelled concerts in 2022 to deal with its symptoms. (hartfordhealthcaremedicalgroup.org)
- The pop icon, 55, revealed in late 2022 that she had been diagnosed with stiff person syndrome, a rare neurological condition that can cause severe muscle stiffness and spasms. (mylucena.com)
- While every person's situation is different, some people are able to manage the symptoms of stiff person syndrome, Dr. Desimir Mijatovic, a pain medicine specialist with the Cleveland Clinic in Ohio, told TODAY.com in 2022. (mylucena.com)
- Dion revealed in December 2022 that she'd been diagnosed with stiff person syndrome and would be postponing tour dates due to the condition. (mylucena.com)
- Dion opened up about her stiff person syndrome diagnosis in a video posted on her Instagram page in December 2022. (mylucena.com)
Amid2
Muscles17
- People with classic SPS typically first experience intermittent tightness or aching in the muscles of the trunk. (wikipedia.org)
- In many people with SPS, muscle rigidity eventually progresses from the trunk to the limbs - first affecting muscles closest to the trunk, then further. (wikipedia.org)
- [ 3 , 4 ] Usually, it begins in the axial muscles and extends to the proximal limb muscles, but the severity of the limb muscle involvement may overwhelm the axial muscle involvement (stiff limb syndrome). (medscape.com)
- Stiff person syndrome usually begins insidiously in the axial muscles. (medscape.com)
- The condition affects one in a million people, and causes muscles to tense uncontrollably, and leaves people like 'human statues' as it locks the body into rigid positions, leaving them unable to walk or talk. (smoothradio.com)
- Muscles gradually become stiffer and enlarge, starting in the trunk and abdomen but eventually affecting muscles throughout the body. (msdmanuals.com)
- When less of this enzyme is produced, nerves overstimulate muscles, which become tight and stiff. (msdmanuals.com)
- In people with stiff-person syndrome, muscles of the trunk and abdomen gradually become stiffer and enlarge. (msdmanuals.com)
- At the later stage, proximal limb muscles get stiffed. (syndromespedia.com)
- Low Frequency of Motor Unit Activity of agonist and antagonist muscles indicates the Stiff Person Syndrome in patients. (syndromespedia.com)
- SPS is a progressive disorder that causes stiff muscles in the torso, arms and legs, and triggers include sensitivity to noise, touch and stress. (hartfordhealthcaremedicalgroup.org)
- People with SPS may have overactivity in their muscles, which can cause tension and stiffness in different areas of their bodies. (com.ng)
- People with the condition can lose the ability to walk or move around due to hyperactivity in their muscles. (com.ng)
- Symptoms of the progressive condition may include stiff muscles in the torso, arms and legs, as well as muscle spasms that may be triggered by noises, touch or emotional distress, according to the National Institute of Neurological Disorders and Stroke . (mylucena.com)
- One theory is that the immune system and autoantibodies causes less GABA to be available - causing overactive nerves that signal the muscles to become stiff, rigid, and continuously contract. (utswmed.org)
- Though there is no cure for stiff person syndrome, medications to help relax the muscles - and in more severe cases, immunotherapy - can help patients manage their symptoms and return to regular activities - whether that's returning to work, playing with the grandkids, or singing on stage. (utswmed.org)
- SPS is characterized by dramatically stiff muscles in the back, chest, abdomen, or arms and legs. (utswmed.org)
Tara Zier1
- Tara Zier is a rare disease patient, mother and the Founder and President of The Stiff Person Syndrome Research Foundation, where the vision is that all people with Stiff Person Syndrome (SPS) receive a prompt diagnosis, compassionate care, effective treatments and a cure. (mitoaction.org)
Dion27
- Was Celine Dion forced to attend her son's wedding in a wheelchair after suffering from Stiff Person Syndrome? (techarp.com)
- People are sharing TikTok and YouTube videos which claim to show Celine Dion attending her son's wedding in a wheelchair, after being diagnosed with Stiff Person Syndrome . (techarp.com)
- Singer Celine Dion attending her son's wedding, she was diagnosed with a rare neurological condition known as stiff-person syndrome. (techarp.com)
- It was only recently that the muscle spasms Celine Dion was suffering from was diagnosed as Stiff Person Syndrome (SPS) - a rare neurological disorder with features of an autoimmune disease. (techarp.com)
- Just to be clear, Celine Dion is not suffering from ALS, but from SPS - Stiff Person Syndrome. (techarp.com)
- While she's been staying out of the public eye as she's handling Stiff-Person Syndrome, Celine Dion made a rare appearance at an ice hockey game in her adopted home of Las Vegas. (yahoo.com)
- Earlier this year, a source told PEOPLE that Dion, 55, was 'doing everything she can' to be healthy enough to get back onstage after canceling her concert dates through April 2024. (yahoo.com)
- Dion first revealed that she was diagnosed with stiff-person syndrome in December in an Instagram video. (yahoo.com)
- Celine Dion has reportedly sold her US home and is moving back to Canada to surround herself with family as she continues to battle Stiff Person Syndrome. (smoothradio.com)
- Celine Dion is fighting her battle with Stiff Person Syndrome and has recently made public appearances. (bing.com)
- Celine Dion is finally feeling better and has things under control after Stiff-Person syndrome diagnosis last year. (bing.com)
- Fact Check: Family of Celine Dion Announced She Is Dying of Stiff-Person Syndrome? (bing.com)
- Céline Dion is "praying for a miracle" as she contends with stiff-person syndrome, her sister Claudette said. (bing.com)
- Celine Dion has performed in public for the first time since she revealed she was diagnosed with the rare neurological disease stiff person syndrome (SPS). (bing.net)
- Celine Dion marked a rare public appearance by unexpectedly performing "a few notes" for the first time since her stiff-person syndrome diagnosis last year. (bing.com)
- Celine Dion health update: What is her illness Stiff Person Syndrome? (bing.com)
- Celine Dion is "doing everything to recover" after being diagnosed with stiff-person syndrome. (bing.com)
- The update comes 8 months after it was revealed that Dion was diagnosed with Stiff-Person Syndrome. (holrmagazine.com)
- Céline Dion dropped a new song for the upcoming movie Love Again, which is her first musical release since sharing her diagnosis with stiff-person syndrome. (nbcbayarea.com)
- In an emotional video on Instagram, Celine Dion reveals she has stiff-person syndrome. (nbcbayarea.com)
- Céline Dion Has Stiff-Person Syndrome. (stiffperson.org)
- Céline Dion opens up about having Stiff Person Syndrome. (stiffperson.org)
- My Heart Will Go On superstar, Celine Dion has cancelled her world tour after revealing she's suffering from an incurable disease called 'stiff-person syndrome', an extremely rare neurological disorder. (netmums.com)
- The Canadian singer Celine Dion revealed that she is diagnosed with a very rare neurological disorder, stiff person syndrome. (powdersvillepost.com)
- Will Celine Dion Still Be Able to Perform With Stiff Person Syndrome? (com.ng)
- In a heartfelt interview with Canadian publication Le Journal de Montréal, Claudette Dion, the sister of the renowned singer Celine Dion, shared a recent update on Celine's health as she continues to grapple with stiff-person syndrome, a rare and challenging neurological disorder characterized by muscle rigidity and spasms. (totalheadline.com)
- Céline Dion delighted her fans as she sang during a hockey game despite her stiff-person syndrome diagnosis. (bunady.com)
Diagnosed with a rare neurological1
- But in a shocking announcement on social media, the singer just told fans that she had been diagnosed with a rare neurological condition known as Stiff Person Syndrome, keeping her from performing some upcoming concert dates she has scheduled. (bestlifeonline.com)
Claudette3
- There's little we can do to support her, to alleviate her pain," said the singer's older sister Claudette Vanessa Etienne is an Emerging Content Writer-Reporter for PEOPLE. (bing.com)
- Canada for an interview published on Thursday, Claudette, 74, gave an update on her sister's recovery from stiff person syndrome. (bing.com)
- Despite the absence of a cure for stiff-person syndrome, Claudette remains hopeful and appreciates the top-notch research Celine is following in the field of this rare disease. (totalheadline.com)
Known as stiff-man synd1
- Stiff-person syndrome (SPS), also known as stiff-man syndrome, is a rare neurologic disorder of unclear cause characterized by progressive muscular rigidity and stiffness. (wikipedia.org)
Cure for stiff-person s3
- Please help support awareness and the search for a cure for Stiff Person Syndrome. (rarediseaseday.org)
- While there is currently no cure for stiff-person syndrome, medical treatments involving specific antibody injections, anti-anxiety medications, and muscle relaxants have proven helpful in managing the symptoms of the disorder. (totalheadline.com)
- There is no cure for stiff person syndrome, although symptoms may be kept under control with certain drugs, as well as physical, occupational and aqua therapy, according to Yale Medicine . (mylucena.com)
Diagnosis of stiff-person s3
- The diagnosis of stiff-person syndrome is suggested by symptoms. (msdmanuals.com)
- Diagnosis of Stiff Person Syndrome can be very complex and confusing as well. (syndromespedia.com)
- Physical examination can also be helpful for the diagnosis of Stiff Person Syndrome. (syndromespedia.com)
Neurologic syndromes2
- Paraneoplastic neurologic syndromes include many neurologic disorders including paraneoplastic cerebellar degeneration (PCD) caused by an immune-mediated mechanism other than a metastatic complication in patients with an underlying malignancy. (medscape.com)
- I think all four really stress a focus on antibody-mediated neurologic syndromes. (medscape.com)
Extremely rare neurological disorder1
- She has stiff-person syndrome (SPS), an extremely rare neurological disorder, and as a result, she canceled her European tour. (stiffperson.org)
Limb syndrome3
- Variants of the condition, such as stiff-limb syndrome which primarily affects a specific limb, are often seen. (wikipedia.org)
- A minority of people with SPS experience "partial" SPS, also called "stiff-limb syndrome", where the muscle contractions and stiffness are limited to the limbs, or sometimes a single limb. (wikipedia.org)
- Sphincter and brainstem issues often occur with stiff-limb syndrome. (wikipedia.org)
Instagram2
- Through an emotional video shared on Instagram, the Grammy-winning artist bravely disclosed her rare neurological disorder, which affects only one in a million people. (totalheadline.com)
- I miss you all so much and can't wait to be on stage talking to you in person," she said in the Instagram video. (bunady.com)
Paraneoplastic5
- Paraneoplastic syndromes are a group of rare disorders that are triggered by an abnormal immune system response to an underlying (usually undetected) malignant tumor. (medscape.com)
- Patients with paraneoplastic neurological syndrome (PNS) most often present with neurologic symptoms before an underlying tumor is detected. (medscape.com)
- However, the oncologic outcome of patients with antibody-associated paraneoplastic syndromes does not significantly differ from that of patients who do not have the antibodies or a paraneoplastic syndrome. (medscape.com)
- An association between paraneoplastic cerebellar degeneration and occult gynecologic cancers (breast or ovarian) was first identified in 1938, and the syndrome was described fully by Brain in 1951. (medscape.com)
- however, in a clinical presentation consistent with a paraneoplastic neurologic syndrome, the chances of underlying malignancy are very high. (medscape.com)
Rare21
- Stiff person syndrome is a rare disease characterized by muscle rigidity that waxes and wanes with concurrent spasms. (medscape.com)
- Recently I've been diagnosed with a very rare neurological disorder called Stiff Person Syndrome which affects something like one-in-a-million people. (techarp.com)
- about her sister's recovery since being diagnosed with stiff-person syndrome , a rare and incurable neurological disease that can cause debilitating muscle spasms. (yahoo.com)
- I came into the rare disease space because I have a rare disease called Stiff Person Syndrome (SPS), which is a rare neurological disease with autoimmune features. (mitoaction.org)
- Stiff-person syndrome (SPS) is a rare neurological disorder. (badtadmd.com)
- Stiff-person syndrome is a rare and progressive neurological disorder, according to the National Institute of Neurological Disorders and Stroke (NINDS). (bing.net)
- Stiff Person Syndrome is a rare neurological disorder that impacts the nervous system of the body. (syndromespedia.com)
- To clarify, stiff-person syndrome (SPS) is a rare, progressive neurological disorder. (holrmagazine.com)
- Karen Long Cecil (pictured), moderator of the SPS Facebook group Stiff Person Syndrome The Official UK and Ireland Support Group , is backing an appeal an NHS appeal for people to register as plasma donors to mark Rare Disease Day [February 28]. (wixsite.com)
- Stiff Person Syndrome (SPS) is a rare, progressive neurological disorder primarily characterized by muscle stiffness, spasms, and functional impairment. (pharmacreations.com)
- Sometimes all it takes to raise awareness of a rare disease is for a famous person to announce they have it. (hartfordhealthcaremedicalgroup.org)
- The Canadian singer cancelled her tour after being struck by a rare condition that affects just one in a million people. (netmums.com)
- It's so rare that it's not something that most people who present with difficulty walking or muscle pain will end up having. (com.ng)
- Stiff person syndrome (SPS) is a rare condition that can impair one's ability to perform daily tasks. (com.ng)
- Stiff person syndrome is a very rare condition that causes severe muscle stiffness and spasms in the back or limbs. (utswmed.org)
- Illness and diseases are common in the US, but did you know there are some extremely rare diseases that only a few people develop? (bewellbuzz.com)
- In the USA, a rare disease is one that affects fewer than 200,000 people. (bewellbuzz.com)
- People with extremely rare diseases are often left facing an incurable disease simply because the funding is not in place to discover more about the condition and potential treatments. (bewellbuzz.com)
- Although there are different ways for an extremely rare disease to develop, it's common that they have no treatment, and people have to manage the symptoms as best they can. (bewellbuzz.com)
- Ochoa syndrome is a rare disease that's best known for the unusual facial expressions it creates. (bewellbuzz.com)
- This syndrome is an extremely rare progressive disease that causes spasms, rigidity, and muscle stiffness. (bewellbuzz.com)
Stiffness8
- Stiff-person syndrome causes muscle stiffness that worsens gradually. (msdmanuals.com)
- Usually, stiff-person syndrome progresses, leading to disability and stiffness throughout the body. (msdmanuals.com)
- In the later stage of Stiff Person Syndrome, the muscle stiffness may spread all over the body. (syndromespedia.com)
- The patients suffering from the Stiff Person Syndrome generally live with the muscle pain and stiffness. (syndromespedia.com)
- Intravenous immunoglobulin (IVIg), a type of antibody treatment, has also been shown to reduce stiffness, sensitivity to noise, touch, and stress for people with SPS.Usually, patients will start with one of the oral medications and then transition to an IVIg treatment over time, Stoll explained. (com.ng)
- He said that people who have difficulty walking or experience muscle stiffness shouldn't assume they have SPS right away. (com.ng)
- The clinical features of muscle stiffness in SJS type I somewhat resemble those seen in myotonic disorders, stiff person syndrome, and Isaacs syndrome. (medscape.com)
- The stiffness does not disappear with sleep or benzodiazepine treatment (as in stiff person syndrome), and it is not abolished reliably with curare (as in Isaacs syndrome). (medscape.com)
Axial muscle1
- The most common symptom of the Stiff Person Syndrome is the initial axial muscle rigidity and pain. (syndromespedia.com)
Disorders5
- Stiff-person syndrome often occurs in people with type 1 diabetes, certain autoimmune disorders, or certain kinds of cancer. (msdmanuals.com)
- Stiff-person syndrome (formerly called stiff-man syndrome) affects mainly the brain and spinal cord (the central nervous system), but it causes symptoms similar to those of some peripheral nerve disorders. (msdmanuals.com)
- I was wondering if stiff-person syndrome is related to some other brain disorders. (mayoclinic.org)
- I know that ALS, alzheimers, parkinsons are nerve degenerative disorders and treatment with L-serine is now under clinical tests that look very promising… Does anyone know if this could help stiff person? (mayoclinic.org)
- I'm hoping someone more knowledgeable about stiff person syndrome can provide some information on your question is it related to other brain disorders. (mayoclinic.org)
Glutamic acid decarbox2
- Most people with stiff-person syndrome have antibodies that attack an enzyme called glutamic acid decarboxylase. (msdmanuals.com)
- The level of Glutamic Acid Decarboxylase (GAD) actually indicates the Stiff Person Syndrome. (syndromespedia.com)
Disorder4
- The features of the disorder are abnormal postures, hunched and stiffed. (syndromespedia.com)
- Stiff person syndrome is a neurological and autoimmune disorder that can cause excruciating muscle spasms and rigidity. (bing.com)
- SPS, also called Moersch-Woltmann syndrome, is a neurological disorder that causes muscle spasms and rigidity. (com.ng)
- Up to 80% of people with stiff person disorder have GAD autoantibodies in their blood. (utswmed.org)
Affects one in a million p1
- it affects one in a million people . (utswmed.org)
Clinical1
- In 1956, Moersch and Woltmann, who also coined the term stiff man syndrome , first clearly described stiff person syndrome as a neurologic clinical entity at the Mayo Clinic. (medscape.com)
Electromyography2
- Doctors suspect stiff-person syndrome based on symptoms but use electromyography and blood tests to help confirm the diagnosis. (msdmanuals.com)
- Apart from it Electromyography is an important tool to diagnose Stiff Person Syndrome. (syndromespedia.com)
Postures1
- People with stiff person syndrome may develop hunched postures and may struggle to walk or move. (mylucena.com)
Moersch-Woltmann1
- [ 2 ] The eponym for this syndrome, Moersch-Woltmann syndrome, is one of the few instances in which the eponym may be the most inclusive and at the same time the most appropriately limiting name for the disease. (medscape.com)
Patient7
- perhaps stiff individual most perfectly describes the affected patient. (medscape.com)
- The patient suffering from Stiff Person Syndrome may not walk properly or move. (syndromespedia.com)
- The patient suffering from Stiff Person Syndrome show deprived sleep and also Rapid Eye Movement (REM) can be experienced. (syndromespedia.com)
- It also reduces the sensitivity of noise, touch and stress among the patient suffering from Stiff Person Syndrome. (syndromespedia.com)
- Life Expectancy of the patient suffering from the Stiff Person Syndrome is dependent on the criticality of the syndrome. (syndromespedia.com)
- The latest updates from The SPSRF -- onboarding with NORD for the patient registry, the Northeast Stiff Person Syndrome Awareness Annual Conference, Super-75 Campaign, and more! (stiffperson.org)
- Would funding support the launch of a patient contact registry for persons with Stiff Person Syndrome? (cdc.gov)
Progressive1
- Notably, stiff-person syndrome is a progressive ailment that can become debilitating if left unmanaged. (totalheadline.com)
Battle1
- she canceled all her live appearances due to her battle with stiff-person syndrome. (bing.com)
Characterized by muscle rigidity1
- Clinically, stiff person syndrome is characterized by muscle rigidity that waxes and wanes with concurrent spasms. (medscape.com)
Treatment4
- Treatment of stiff-person syndrome focuses on relieving symptoms. (msdmanuals.com)
- Even though the treatment for the Stiff Person Syndrome is available but that does no cure the syndrome. (syndromespedia.com)
- @sanghamitra Treatment for stiff person syndrome is based on your symptoms. (reanfoundation.org)
- [ 1 ] These syndromes are difficult to diagnose and respond poorly to treatment. (medscape.com)
Antibodies7
- In stiff-person syndrome, these antibodies attack nerve cells in the spinal cord that control muscle movement. (msdmanuals.com)
- and blood tests to detect the antibodies that are present in many people with stiff-person syndrome. (msdmanuals.com)
- Finally, a blood test came back positive for Anti-GAD 65 antibodies, and the patient's regular doctor diagnosed her with Stiff-Person Syndrome. (badtadmd.com)
- The exact role of the GAD enzyme and GAD antibodies in stiff person syndrome isn't fully understood - approximately 20% of patients with the condition do not have GAD antibodies. (utswmed.org)
- Conversely, many people with GAD antibodies don't have SPS (for example, millions of people with Type 1 diabetes in the U.S. likely have GAD antibodies). (utswmed.org)
- Specific forms of this syndrome often are associated with specific antineuronal antibodies and tumors. (medscape.com)
- Therefore, detection of these antibodies greatly assists the diagnosis of this syndrome and prompts investigations for the underlying tumor. (medscape.com)
Autoantibodies1
- High titers in the patient's serum and cerebrospinal fluid (CSF) of autoantibodies directed against both neurons and tumor have been detected in some forms of this syndrome. (medscape.com)
Severe1
- People with stiff person syndrome may experience severe muscle cramps . (powdersvillepost.com)
Condition5
- The condition, according to the Stiff Person Syndrome Foundation , affects the central nervous system, specifically the brain and spinal cord. (yahoo.com)
- Check out http://en.wikipedia.org/wiki/Stiff-Person_Syndrome for more information on this amazing and sad condition. (badtadmd.com)
- Am interested in connecting with people who have this or are significant others of people who have this condition. (mayoclinic.org)
- A lot of people are able to make recovery to the point that their condition is stable. (mylucena.com)
- This is a condition where a person is born with organs situated on the opposite side of the body. (bewellbuzz.com)
Enzyme1
- The range of diseases encountered includes seizures, cerebellar dysfunction, cortical dysfunction, and myelopathy, but the association between function of the enzyme and the consequence of the disease is most clear in patients with stiff person syndrome. (medscape.com)
Public appearance1
- she hasn't made a public appearance in nearly four years, People reports. (popsugar.com)
Diseases3
- Stiff person syndrome is rather unique among neurologic diagnoses because of its lack of significant similarity to any other neurologic diseases. (medscape.com)
- More than 300 million people are affected by these diseases at some point in their lives, which adds up to about the population of the United States! (csipharmacy.com)
- Autoimmune diseases do tend to run in families, which means that certain genes may make some people more likely to develop a problem. (medlineplus.gov)
Antibody1
- Endocrinologists were excited by a discovery in the 1980s of an antibody to a 65-kd protein that was strongly associated with adult-onset diabetes mellitus and stiff person syndrome. (medscape.com)
Research Foundation2
- Can you share what The Stiff Person Syndrome Research Foundation is doing right now? (mitoaction.org)
- He joined the medical advisory board of the national Stiff Person Syndrome Research Foundation, a group focused on collecting cases in a registry to power research into therapeutic treatments. (hartfordhealthcaremedicalgroup.org)
Occurs1
- SPS occurs in about one in a million people and is most commonly found in middle-aged people. (wikipedia.org)
Spasms2
- According to the Stiff Person Syndrome Foundation, it's described as "a neurological disease with autoimmune features" with symptoms including "muscle spasms, hyper-rigidity, debilitating pain, and chronic anxiety. (bestlifeonline.com)
- People with SPS can be too disabled to walk or move, or they are afraid to leave the house because street noises, such as the sound of a horn, can trigger spasms and falls. (bestlifeonline.com)
Update1
- Opinion, findings and conclusions expressed by the original authors of items included in the update, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. (cdc.gov)
Muscle4
- Muscle rigidity is the major reason for pain and problem for Stiff Person Syndrome. (syndromespedia.com)
- Apart from it anti anxiety drugs, muscle relaxants, anti convulsants and pain relief drugs are used as part of the support programme for the Stiff Person Syndrome patients. (syndromespedia.com)
- People may also fall more frequently because they lack the muscle reflexes to catch themselves, which can lead to injury. (mylucena.com)
- Stiff person syndrome isn't curable but can be managed with muscle relaxants, physiotherapy, and exercise. (bewellbuzz.com)