Cytotoxic cardenolide glycosides of Roupellina (Strophanthus) boivinii from the Madagascar rainforest. (1/2)
Bioassay-guided fractionation of an ethanol extract of Roupellina (Strophanthus) boivinii from the rainforest of Madagascar afforded the six new cardenolide glycosides boivinides 1-6, as well as the four known cardenolide glycosides digitoxigenin 3-O-[beta-D-glucopyrananosyl-(1-->4)-alpha-L-acofriopyranoside], corotoxigenin 3-O-beta-D-boivinoside, 17alpha-corotoxigenin 3-O-beta-D-sarmentoside, and uzarigenin 3-O-alpha-L-rhamnoside. The structures of these compounds were elucidated by various 1D and 2D NMR techniques. All new compounds showed significant antiproliferative activity against the A2780 human ovarian cancer cell line, with boivinide A being the most active at IC50 = 0.17 microM. (+info)Glycosylation of trans-resveratrol by plant-cultured cells. (2/2)
Plant-cultured cells of Catharanthus roseus converted trans-resveratrol into its 3-O-beta-D-glucopyranoside, 4'-O-beta-D-glucopyranoside, 3-O-(6-O-beta-D-xylopyranosyl)-beta-D-glucopyranoside, and 3-O-(6-O-alpha-L-arabinopyranosyl)-beta-D-glucopyranoside. The 3-O-(6-O-beta-D-xylopyranosyl)-beta-D-glucopyranoside and 3-O-(6-O-alpha-L-arabinopyranosyl)-beta-D-glucopyranoside compounds of trans-resveratrol are both new. Incubation of plant-cultured cells of Ipomoea batatas and Strophanthus gratus with trans-resveratrol gave trans-resveratrol 3-O-beta-D-glucopyranoside and trans-resveratrol 4'-O-beta-D-glucopyranoside. (+info)Strophanthus is not a medical term itself, but it refers to a genus of plants that contain cardiac glycosides, which have been used in traditional medicine and pharmacology. The most notable cardiac glycoside found in Strophanthus species is strophanthin (ouabain).
Strophanthin has positive inotropic (contractility-enhancing) and negative chronotropic (rate-slowing) effects on the heart, making it useful in treating various cardiac conditions. However, due to its narrow therapeutic index and potential toxicity, strophanthin is not commonly used in modern medicine.
In a medical context, when referring to 'Strophanthus,' it would typically be in relation to these pharmacological properties or historical/traditional uses of the plant's extracts.