Taxus
Paclitaxel
Drug-Eluting Stents
Coronary Restenosis
Cardiovascular Agents
Plant Poisoning
Tubulin Modulators
Chromium Alloys
Angioplasty, Balloon, Coronary
Hawks
Encyclopedias as Topic
Paris
Restaurants
Water
New taxane diterpenoid from seed of the Chinese yew, Taxus yunnanensis. (1/79)
A novel taxane diterpenoid with a rearranged 5/7/6-membered ring system was isolated from seeds of the Chinese yew, Taxus yunnanensis. Its structure was established as 9alpha,13alpha-diacetoxy-10beta-benzoxy-5alpha- cinnamoyl-11(1 5-->1)-abeotaxa-4(20),11-dien-15-ol on the basis of a spectroscopic analysis. Its relative stereochemistry is proposed from the results of NOESY experiments. (+info)Two novel taxane diterpenoids from the needles of Japanese yew, Taxus cuspidata. (2/79)
Two novel taxane diterpenoids were isolated from the needles of Japanese yew, Taxus cuspidata, and their structures were determined to be lbeta-hydroxy-7beta-acetoxytaxinine (1) and lbeta,7beta-dihydroxytaxinine (2) on the basis of spectral analyses including 2D-NMR studies. (+info)Reversal of P-glycoprotein and multidrug-resistance protein-mediated drug resistance in KB cells by 5-O-benzoylated taxinine K. (3/79)
A newly synthesized taxoid originally from the Japanese yew Taxus cuspidata, 5-O-benzoylated taxinine K (BTK) was examined for its ability to reverse P-glycoprotein (P-gp) and multidrug resistance protein (MRP)-mediated multidrug resistance. BTK reversed the resistance to paclitaxel, doxorubicin (ADM), and vincristine (VCR) of KB-8-5 and KB-C2 cells that overexpress P-gp by directly interacting with P-gp. BTK also moderately reversed the resistance to ADM of KB/MRP cells that overexpress MRP. However, BTK neither inhibited the transporting activity of MRP nor reduced intracellular glutathione levels in KB/MRP cells. BTK shifted the distribution of ADM in KB/MRP cells from punctate cytoplasmic compartments to the nucleoplasm and cytoplasm by inhibiting acidification of cytoplasmic organelles. These two functions of BTK make it able to reverse both P-gp- and MRP-mediated MDR. BTK in combination with ADM should be useful for treating patients with tumors that overexpress both P-gp and MRP. (+info)Intramolecular proton transfer in the cyclization of geranylgeranyl diphosphate to the taxadiene precursor of taxol catalyzed by recombinant taxadiene synthase. (4/79)
BACKGROUND: The committed step in the biosynthesis of the anticancer drug taxol in yew (Taxus) species is the cyclization of geranylgeranyl diphosphate to taxa-4(5),11(12)-diene. The enzyme taxadiene synthase catalyzes this complex olefin cation cyclization cascade involving the formation of three rings and three stereogenic centers. RESULTS: Recombinant taxadiene synthase was incubated with specifically deuterated substrates, and the mechanism of cyclization was probed using MS and NMR analyses of the products to define the crucial hydrogen migration and terminating deprotonation steps. The electrophilic cyclization involves the ionization of the diphosphate with closure of the A-ring, followed by a unique intramolecular transfer of the C11 proton to the re-face of C7 to promote closure of the B/C-ring juncture, and cascade termination by proton elimination from the beta-face of C5. CONCLUSIONS: These findings provide insight into the molecular architecture of the first dedicated step of taxol biosynthesis that creates the taxane carbon skeleton, and they have broad implications for the general mechanistic capability of the large family of terpenoid cyclization enzymes. (+info)New 11(15-->1)abeotaxane, 11(15-->1),11(10-->9)bisabeotaxane and 3,11-cyclotaxanes from Taxus yunnanensis. (5/79)
Chemical examination of the seeds of Chinese yew, Taxus yunnanensis Cheng et L. K. Fu resulted in the isolation of an 11(15-->1)abeotaxane, an 11(15-->1), 11(10-->9)bisabeotaxane and two 3,11-cyclotaxanes. The structures of these new taxoids were established as 13alpha-acetoxy-5alpha-cinnamoyloxy-11(15-->1)abeotaxa-4(20),11-diene-9alpha,10be ta,15-triol (1), 20-acetoxy-2alpha-benzoyloxy-4alpha, 5alpha, 7beta, 9alpha, 13alpha-pentahydroxy-11(15-->1), 11(10-->9) bisabeotax-11-eno-10,15-lactone (2), 2alpha,10beta-diacetoxy-5alpha-cinnamoyloxy-9alpha-hydroxy-3,11 -cyclotax-4(20)-en-13-one (3) and 10beta-acetoxy-2alpha,5alpha,9alpha-trihydroxy-3,11-cyclotax-4(20)-en-13-one (4) on the basis of spectral analyses. (+info)Taxol biosynthesis: taxane 13 alpha-hydroxylase is a cytochrome P450-dependent monooxygenase. (6/79)
A central feature in the biosynthesis of Taxol is oxygenation at multiple positions of the taxane core structure, reactions that are considered to be mediated by cytochrome P450-dependent monooxygenases. A PCR-based differential display-cloning approach, using Taxus (yew) cells induced for Taxol production, yielded a family of related cytochrome P450 genes, one of which was assigned as a taxane 10 beta-hydroxylase by functional expression in yeast. The acquired clones that did not function in yeast were heterologously expressed by using the Spodoptera fugiperda-baculovirus-based system and were screened for catalytic capability by using taxa-4(20),11(12)-dien-5 alpha-ol and its acetate ester as test substrates. This approach allowed identification of one of the cytochrome P450 clones (which bore 63% deduced sequence identity to the aforementioned taxane 10 beta-hydroxylase) as a taxane 13 alpha-hydroxylase by chromatographic and spectrometric characterization of the corresponding recombinant enzyme product. The demonstration of a second relevant hydroxylase from the induced family of cytochrome P450 genes validates this strategy for elucidating the oxygenation steps of taxane diterpenoid (taxoid) metabolism. Additionally, substrate specificity studies with the available cytochrome P450 hydroxylases now indicate that there is likely more than one biosynthetic route to Taxol in yew species. (+info)New taxane diterpenoids from the roots of Taiwanese Taxus mairei. (7/79)
Five new taxane diterpenoids, taxumairols G (1), H (2), I (3), J (4), and L (5) were isolated from extracts of the roots of Taiwanese Taxus mairei (LEMEE & LEVL.) S. Y. Hu. Compounds 1-4 belong to the new 11(15-->1)-abeo-taxene system, having a tetrahydrofuran ring along carbons C-2, C-3, C-4 and C-20. Compounds 3 and 4 contain an isopropenyl group at C-1 while compounds 1 and 2 are attached with a benzoxyl group at C-15. The structures of compounds 1-5 were determined on the basis of two-dimensional (2D)-NMR techniques including correlation spectroscopy (COSY), heteronuclear single quantum coherence (HSQC), heteronuclear multiple bond correlation (HMBC), and nuclear Overhauser effect spectroscopy (NOESY) experiments. (+info)The final acylation step in taxol biosynthesis: cloning of the taxoid C13-side-chain N-benzoyltransferase from Taxus. (8/79)
The formation of several acyl groups and an amide group of Taxol is catalyzed by regioselective CoA thioester-dependent acyltransferases. Several full-length acyltransferase sequences, obtained from a cDNA library constructed from mRNA isolated from Taxus cuspidata cells induced for Taxol production with methyl jasmonate, were individually expressed in Escherichia coli, from which a cDNA clone encoding a 3'-N-debenzoyl- 2'-deoxytaxol N-benzoyltransferase was identified. This recombinant enzyme catalyzes the stereoselective coupling of the surrogate substrate N-debenzoyl-(3'RS)-2'-deoxytaxol with benzoyl-CoA to form predominantly one 3'-epimer of 2'-deoxytaxol. The product 2'-deoxytaxol was confirmed by radio-HPLC,(1)H-NMR, and chemical ionization-MS. This enzymatic reaction constitutes the final acylation in the Taxol biosynthetic pathway. The full-length cDNA coding for the N-benzoyltransferase has an ORF of 1,323 nucleotides and encodes a 441-residue protein with a calculated molecular weight of 49,040. The recombinant enzyme expressed in E. coli has a pH optimum at 8.0, a k(cat) approximately 1.5 +/- 0.3 s(-1) and K(m) values of 0.42 mM and 0.40 mM for the N-deacylated taxoid and benzoyl-CoA, respectively. In addition to improving the production yields of Taxol in genetically engineered host systems, this enzyme provides a means of attaching modified aroyl groups to taxoid precursors for the purpose of improving drug efficacy. (+info)"Taxus" is a genus of evergreen trees and shrubs, also known as yews. While it is primarily a term used in botanical classification, some species of this plant have medicinal importance. The most notable example is "Taxus brevifolia," or the Pacific Yew, from which the chemotherapy drug Paclitaxel (also known as Taxol) is derived. This drug is used to treat various types of cancer, including ovarian, breast, and lung cancers. It works by interfering with the division of cancer cells. Please note that Paclitaxel must be administered under the supervision of a medical professional, as it can have serious side effects.
Paclitaxel is a chemotherapeutic agent derived from the bark of the Pacific yew tree (Taxus brevifolia). It is an antimicrotubule agent that promotes the assembly and stabilization of microtubules, thereby interfering with the normal dynamic reorganization of the microtubule network that is essential for cell division.
Paclitaxel is used in the treatment of various types of cancer including ovarian, breast, lung, and pancreatic cancers. It works by inhibiting the disassembly of microtubules, which prevents the separation of chromosomes during mitosis, leading to cell cycle arrest and apoptosis (programmed cell death).
Common side effects of paclitaxel include neutropenia (low white blood cell count), anemia (low red blood cell count), alopecia (hair loss), peripheral neuropathy (nerve damage causing numbness or tingling in the hands and feet), myalgias (muscle pain), arthralgias (joint pain), and hypersensitivity reactions.
Drug-eluting stents (DES) are medical devices used in the treatment of coronary artery disease. They are small, flexible tubes that are coated with a medication that is slowly released (eluted) over time to prevent the formation of scar tissue and reduce the risk of renarrowing (restenosis) of the artery after it has been treated with angioplasty and stenting.
The stent is typically placed in a narrowed or blocked coronary artery during a percutaneous coronary intervention (PCI) procedure, such as angioplasty, to open up the blood vessel and improve blood flow to the heart muscle. The medication on the DES helps to prevent the growth of smooth muscle cells and the formation of scar tissue in the artery, which can cause restenosis and require additional treatments.
The most commonly used medications on DES are sirolimus, paclitaxel, zotarolimus, and everolimus. These drugs work by inhibiting the growth of smooth muscle cells and reducing inflammation in the artery. While DES have been shown to reduce the risk of restenosis compared to bare-metal stents, they also carry a small increased risk of late stent thrombosis (blood clots forming in the stent), which can lead to serious complications such as heart attack or stroke. Therefore, patients who receive DES are typically prescribed long-term antiplatelet therapy to reduce this risk.
Coronary restenosis is the re-narrowing or re-occlusion of a coronary artery after a previous successful procedure to open or widen the artery, such as angioplasty or stenting. This narrowing is usually caused by the excessive growth of scar tissue or smooth muscle cells in the artery lining, which can occur spontaneously or as a response to the initial procedure. Restenosis can lead to recurrent symptoms of coronary artery disease, such as chest pain or shortness of breath, and may require additional medical intervention.
Cardiovascular agents are a class of medications that are used to treat various conditions related to the cardiovascular system, which includes the heart and blood vessels. These agents can be further divided into several subcategories based on their specific mechanisms of action and therapeutic effects. Here are some examples:
1. Antiarrhythmics: These drugs are used to treat abnormal heart rhythms or arrhythmias. They work by stabilizing the electrical activity of the heart and preventing irregular impulses from spreading through the heart muscle.
2. Antihypertensives: These medications are used to lower high blood pressure, also known as hypertension. There are several classes of antihypertensive drugs, including diuretics, beta-blockers, calcium channel blockers, and angiotensin-converting enzyme (ACE) inhibitors.
3. Anticoagulants: These drugs are used to prevent blood clots from forming or growing larger. They work by interfering with the coagulation cascade, which is a series of chemical reactions that lead to the formation of a blood clot.
4. Antiplatelet agents: These medications are used to prevent platelets in the blood from sticking together and forming clots. They work by inhibiting the aggregation of platelets, which are small cells in the blood that help form clots.
5. Lipid-lowering agents: These drugs are used to lower cholesterol and other fats in the blood. They work by reducing the production or absorption of cholesterol in the body or increasing the removal of cholesterol from the bloodstream. Examples include statins, bile acid sequestrants, and PCSK9 inhibitors.
6. Vasodilators: These medications are used to widen blood vessels and improve blood flow. They work by relaxing the smooth muscle in the walls of blood vessels, causing them to dilate or widen. Examples include nitrates, calcium channel blockers, and ACE inhibitors.
7. Inotropes: These drugs are used to increase the force of heart contractions. They work by increasing the sensitivity of heart muscle cells to calcium ions, which are necessary for muscle contraction.
These are just a few examples of cardiovascular medications that are used to treat various conditions related to the heart and blood vessels. It is important to note that these medications can have side effects and should be taken under the guidance of a healthcare provider.
Plant poisoning is a form of poisoning that occurs when someone ingests, inhales, or comes into contact with any part of a plant that contains toxic substances. These toxins can cause a range of symptoms, depending on the type and amount of plant consumed or exposed to, as well as the individual's age, health status, and sensitivity to the toxin.
Symptoms of plant poisoning may include nausea, vomiting, diarrhea, abdominal pain, difficulty breathing, skin rashes, seizures, or in severe cases, even death. Some common plants that can cause poisoning include poison ivy, poison oak, foxglove, oleander, and hemlock, among many others.
If you suspect plant poisoning, it is important to seek medical attention immediately and bring a sample of the plant or information about its identity if possible. This will help healthcare providers diagnose and treat the poisoning more effectively.
Tubulin modulators are a class of drugs that target and alter the function or structure of tubulin, which is a key component of microtubules in cells. These drugs can either stabilize or destabilize microtubules by interacting with tubulin, leading to various effects on cell division and other processes that rely on microtubule dynamics.
There are two main types of tubulin modulators:
1. Microtubule stabilizers: These drugs promote the assembly and stability of microtubules by binding to tubulin, preventing its disassembly. Examples include taxanes (e.g., paclitaxel) and vinca alkaloids (e.g., vinblastine). They are primarily used as anticancer agents because they interfere with the division of cancer cells.
2. Microtubule destabilizers: These drugs inhibit the formation and stability of microtubules by binding to tubulin, promoting its disassembly. Examples include colchicine, vinca alkaloids (e.g., vinorelbine), and combretastatins. They can also be used as anticancer agents because they disrupt the mitotic spindle during cell division, leading to cancer cell death.
Tubulin modulators have various other effects on cells beyond their impact on microtubules, such as interfering with intracellular transport and signaling pathways. These diverse actions contribute to their therapeutic potential in treating diseases like cancer, but they can also lead to side effects that limit their clinical use.
Prosthesis design is a specialized field in medical device technology that involves creating and developing artificial substitutes to replace a missing body part, such as a limb, tooth, eye, or internal organ. The design process typically includes several stages: assessment of the patient's needs, selection of appropriate materials, creation of a prototype, testing and refinement, and final fabrication and fitting of the prosthesis.
The goal of prosthesis design is to create a device that functions as closely as possible to the natural body part it replaces, while also being comfortable, durable, and aesthetically pleasing for the patient. The design process may involve collaboration between medical professionals, engineers, and designers, and may take into account factors such as the patient's age, lifestyle, occupation, and overall health.
Prosthesis design can be highly complex, particularly for advanced devices such as robotic limbs or implantable organs. These devices often require sophisticated sensors, actuators, and control systems to mimic the natural functions of the body part they replace. As a result, prosthesis design is an active area of research and development in the medical field, with ongoing efforts to improve the functionality, comfort, and affordability of these devices for patients.
Chromium alloys are materials made by combining chromium with other metals, such as nickel, cobalt, or iron. The addition of chromium to these alloys enhances their properties, making them resistant to corrosion and high temperatures. These alloys have a wide range of applications in various industries, including automotive, aerospace, and medical devices.
Chromium alloys can be classified into two main categories: stainless steels and superalloys. Stainless steels are alloys that contain at least 10.5% chromium by weight, which forms a passive oxide layer on the surface of the material, protecting it from corrosion. Superalloys, on the other hand, are high-performance alloys designed to operate in extreme environments, such as jet engines and gas turbines. They contain significant amounts of chromium, along with other elements like nickel, cobalt, and molybdenum.
Chromium alloys have several medical applications due to their excellent properties. For instance, they are used in surgical instruments, dental implants, and orthopedic devices because of their resistance to corrosion and biocompatibility. Additionally, some chromium alloys exhibit superelasticity, a property that allows them to return to their original shape after being deformed, making them suitable for use in stents and other medical devices that require flexibility and durability.
Coronary balloon angioplasty is a minimally invasive medical procedure used to widen narrowed or obstructed coronary arteries (the blood vessels that supply oxygen-rich blood to the heart muscle) and improve blood flow to the heart. This procedure is typically performed in conjunction with the insertion of a stent, a small mesh tube that helps keep the artery open.
During coronary balloon angioplasty, a thin, flexible catheter with a deflated balloon at its tip is inserted into a blood vessel, usually through a small incision in the groin or arm. The catheter is then guided to the narrowed or obstructed section of the coronary artery. Once in position, the balloon is inflated to compress the plaque against the artery wall and widen the lumen (the inner space) of the artery. This helps restore blood flow to the heart muscle.
The procedure is typically performed under local anesthesia and conscious sedation to minimize discomfort. Coronary balloon angioplasty is a relatively safe and effective treatment for many people with coronary artery disease, although complications such as bleeding, infection, or re-narrowing of the artery (restenosis) can occur in some cases.
I'm not aware of a specific medical definition for "bathing beaches." The term "bathing beach" is commonly used to refer to a public shoreline area, such as on a lake or ocean, that is designated for swimming or bathing. However, in a public health context, the term might be used to describe a body of water where people are more likely to swim and therefore where water quality and safety need to be closely monitored.
Public health agencies may test the water at bathing beaches for contaminants such as bacteria or chemicals that could pose a risk to swimmers' health. If high levels of these contaminants are detected, the agency may issue an advisory or closure of the beach to protect public health. For example, the U.S. Environmental Protection Agency (EPA) sets standards for water quality at bathing beaches and provides guidance to states and localities on monitoring and managing beach water quality.
I'm sorry for any confusion, but "Hawks" is not a commonly used medical term. It is most frequently associated with the bird of prey or a sports team name. If you have encountered this term in a medical context and are unsure of its meaning, I would recommend checking the source again or consulting with a healthcare professional for clarification.
An encyclopedia is a comprehensive reference work containing articles on various topics, usually arranged in alphabetical order. In the context of medicine, a medical encyclopedia is a collection of articles that provide information about a wide range of medical topics, including diseases and conditions, treatments, tests, procedures, and anatomy and physiology. Medical encyclopedias may be published in print or electronic formats and are often used as a starting point for researching medical topics. They can provide reliable and accurate information on medical subjects, making them useful resources for healthcare professionals, students, and patients alike. Some well-known examples of medical encyclopedias include the Merck Manual and the Stedman's Medical Dictionary.
I'm sorry for any confusion, but "Paris" is not a medical term. Paris is the capital city of France, known for its rich history, art, fashion, and cuisine. If you have any questions related to medical topics or definitions, I would be happy to help with those.
I believe there might be a misunderstanding in your question. "Restaurants" are establishments where food and drinks are prepared and served to customers for a profit. They are part of the hospitality industry, not a medical term or concept. If you have any questions about medical terminology or concepts, I would be happy to help!
Medical definitions of water generally describe it as a colorless, odorless, tasteless liquid that is essential for all forms of life. It is a universal solvent, making it an excellent medium for transporting nutrients and waste products within the body. Water constitutes about 50-70% of an individual's body weight, depending on factors such as age, sex, and muscle mass.
In medical terms, water has several important functions in the human body:
1. Regulation of body temperature through perspiration and respiration.
2. Acting as a lubricant for joints and tissues.
3. Facilitating digestion by helping to break down food particles.
4. Transporting nutrients, oxygen, and waste products throughout the body.
5. Helping to maintain healthy skin and mucous membranes.
6. Assisting in the regulation of various bodily functions, such as blood pressure and heart rate.
Dehydration can occur when an individual does not consume enough water or loses too much fluid due to illness, exercise, or other factors. This can lead to a variety of symptoms, including dry mouth, fatigue, dizziness, and confusion. Severe dehydration can be life-threatening if left untreated.
Public-Private Sector Partnerships (PPPs) in the context of healthcare, according to the World Health Organization (WHO), are "arrangements between public and private sector entities based on clearly defined roles and responsibilities, where all participants share risks and benefits, in which a significant portion of the investment and/or risk is taken on by the private sector partner(s) for the delivery of an essential healthcare service."
PPPs can take various forms, such as:
1. Service contracts: The public sector hires a private company to manage and operate specific services.
2. Management contracts: A private entity manages and operates public health facilities or services while the ownership remains with the government.
3. Public-private mixed ownership: Both public and private sectors share ownership of an enterprise, often through joint ventures.
4. Lease agreements: The government leases its healthcare infrastructure to a private company for management and operation.
5. Joint financing arrangements: Both public and private sectors contribute funds towards the development or expansion of healthcare services.
6. Corporate Social Responsibility (CSR) initiatives: Private companies support healthcare projects as part of their CSR commitments.
PPPs aim to improve access, quality, and efficiency in healthcare delivery while promoting innovation and financial sustainability. However, they also pose challenges related to governance, accountability, and potential conflicts of interest. Therefore, careful planning, monitoring, and evaluation are essential for successful PPPs in the healthcare sector.
Taxus
Taxus × media
Taxus canadensis
Taxus floridana
Taxus mairei
Taxus contorta
Taxus cuspidata
Taxus sumatrana
Taxus brevifolia
Taxus masonii
Taxus globosa
Taxus chinensis
Taxus celebica
Taxus wallichiana
Taxus baccata
Taxi!
Taxi
Taxi!!!
Taxis
Taxi Chor
Easy Taxi
Taxi Sense
Bicycle taxi
Pet taxi
Water taxi
Odd Taxi
Taxi Violence
Taxi Blues
Taxi Brooklyn
Taxus - Wikipedia
Taxi Drivers
Taxi Drivers
Water Taxi Beach - Wikipedia
A1 Taxis videos - Dailymotion
Ola Taxi - Articles & Biography | Entrepreneur
Taxi ranks - Transport for London
MCDOT - Taxi Users
TAXI
Taxi Drivers How to Prevent Robbery | NIOSH | CDC
Taxi Services - Yahoo Local Search Results
Taxi Driver - The Simulation on Steam
Bombay Taxi | Addicting Games
Bronzeville taxi driver robbed; police seek attacker
Bangkok Plugging Into Electric Taxis - CSMonitor.com
JoJo Pets Taxi (@jojopetstaxi) | TikTok
Istanbul Taxi Complaints
Links - Rain Taxi
taxi Archives - Marketplace
Massachusetts will tax ridesharing services to compensate taxis
Excellent service - Nerja Taxis, Nerja Traveller Reviews - Tripadvisor
Atu Taxi on the App Store
Taxi apps
Taxi fares to rise in NYC
In Historic Ruling, NLRB Says Tucson Taxi Drivers are Employees
MALLET EYES - Rain Taxi
Karen Mitchell | TAXI Member
All Hail ... Taxi - Marketplace
20192
- Police are asking for the public's help in finding a man who robbed a taxi driver on June 3, 2019, in the Bronzeville neighborhood. (baltimoresun.com)
- In 2019, the country was ranked number 2 among other countries in Road Freight Volume of Taxi Operation Sector with 12 Thousand Journeys. (nationmaster.com)
Uber and Lyft1
- It's the first known US attempt to directly subsidize taxis through the likes of Uber and Lyft. (engadget.com)
Baccata3
- under this treatment, the species name used is Taxus baccata, the first yew described scientifically. (wikipedia.org)
- Plants of the World Online recognizes 12 confirmed species: Taxus baccata L., European yew Taxus brevifolia Nutt. (wikipedia.org)
- Oregon, USA †Taxus schornii - Miocene, northern Idaho Commonly reported hybrids Taxus × media = Taxus baccata × Taxus cuspidata Taxus × hunnewelliana = Taxus cuspidata × Taxus canadensis Below are cladograms showing the evolutionary relationships between yew species and their global distribution. (wikipedia.org)
Cabs2
- One thing that's new (for me) is that the taxi meter on most of the cabs we took displayed the information in light blue diodes on the rear-view mirror , and it flashes on and off. (turkeytravelplanner.com)
- Cabs, taxis, Ola, Uber, privately owned but yellow number plated cars, et should no more be the base model of the car. (change.org)
Shuttles1
- En route, the shuttles will also call at a river-bus stop and a cable car terminal. (newscientist.com)
Hail2
- Yes, every Lyft or Uber you hail will directly fund the taxis they're competing against. (engadget.com)
- Riders used an app to hail electric taxis driven by salaried drivers. (cbc.ca)
Autonomous1
- Boeing is investing $450 million in Wisk, which is working on autonomous, electric air taxis. (popsci.com)
Passengers4
- Passengers board a Chicago Water Taxi on July 5, 2018, along the Chicago Riverwalk. (chicagotribune.com)
- The taxis could carry hundreds of passengers daily during the trial, according to Simon Tong at TRL, a transport consultancy involved in the work. (newscientist.com)
- Getting into a taxi when traveling could result in passengers paying more than they should, so the 'hagglestar' app is positioned as a way to help travelers avoid overpaying by keeping them informed. (trendhunter.com)
- Taxi drivers and passengers are exposed to high levels of traffic-related air pollutants, but their exposures to fine (PM2.5) and ultrafine particles (UFPs) and related mitigation strategies are rarely explored. (cdc.gov)
Traditional taxi3
- Reuters notes that he same law also lets companies pick you up at traditional taxi bastions like the airport or convention center, albeit with limits. (engadget.com)
- Taillefer co-founded Téo Taxi, an app-based service, in 2015 and bought out two of the main traditional taxi companies that operate in Montreal as well. (cbc.ca)
- With backers including Goldman Sachs and BlackRock and valued at more than $70 billion, Uber has faced protests, bans and restrictions around the world as it challenges traditional taxi operators, angering some unions. (yahoo.com)
Buses1
- Booked four taxis over the week of our visit and the service overall was very poor must do better or people will choose other resorts which would be a shame as Nerja is a great resort but taxis and buses can do better. (tripadvisor.co.uk)
Branch1
- Rigid branch yew, Japanese yew Taxus floridana Nutt. (wikipedia.org)
Service12
- For some suspensions, a temporary taxi rank must be provided to ensure that there is still designated space for taxi drivers to provide a service to the public. (tfl.gov.uk)
- The Maryland Public Service Commission, which regulates the taxi industry in Maryland, has authorized Montgomery County to regulate local taxicab service. (montgomerycountymd.gov)
- Although it could improve the overall quality of taxi service, it's still protecting one industry at the expense of another. (engadget.com)
- When I visited New York two years ago, I was amazed at how efficient and cheap the New York taxi service was. (kottke.org)
- Chicago Water Taxi service started in 2007 and has been on an "upward trajectory" since then, seeing more than 400,000 riders last year. (chicagotribune.com)
- The Metropolitan Planning Council, a Chicago-based public policy research group, issued a report in 2016 supporting "infill" water taxi stations on both North and South branches of the river, and recommended integrating the service into Ventra, transit system maps, on-board announcements, schedules and system planning. (chicagotribune.com)
- The council's report also suggested looking at the longer-term feasibility of expanding water taxi service south from Ping Tom Park on the Chicago River and on the Calumet River. (chicagotribune.com)
- Blade, a New York-based "urban air mobility" provider, announced Thursday it has partnered with the downtown heliport Vertiport Chicago to launch air taxi service as early as this summer. (chicagotribune.com)
- Blade, a New York-based "urban air mobility" provider, hopes to eventually use electric vertical aircraft, seen in an artist's rendering, for a planned air taxi service to O'Hare International Airport. (chicagotribune.com)
- Founded in 2014, Blade has established helicopter air taxi service in New York, Miami and India. (chicagotribune.com)
- Dubai has conducted its first test of a drone taxi service that it hopes will become a viable transportation system in the city. (bbc.com)
- Driverless taxis are coming into service elsewhere, too. (newscientist.com)
Drivers16
- Industries with the highest published employment and wages for Taxi Drivers are provided. (bls.gov)
- For a list of all industries with employment in Taxi Drivers, see the Create Customized Tables function. (bls.gov)
- Taxi drivers who receive a Penalty Charge Notice (PCN) from a borough or from us can appeal against this. (tfl.gov.uk)
- This fact sheet recommends strategies for taxi drivers to prevent or reduce the likelihood of violence during a shift. (cdc.gov)
- Before being licensed our drivers have an independent local authority endorsed taxi driving assessment. (google.com)
- This article (in English, 2018) from Hürriyet Daily News , a prominent Turkish newspaper, shows that the bad taxi drivers victimize not just foreign visitors, but Istanbullus as well. (turkeytravelplanner.com)
- If you have a drink or meal in a restaurant and need a Taxi it will be there in under 10mins and the drivers are friendly. (tripadvisor.co.uk)
- TUCSON, Ariz. , Oct. 28, 2015 /PRNewswire-USNewswire/ -- In a groundbreaking ruling, the National Labor Relations Board (NLRB) in Tucson, Arizona , has determined that more than 200 taxi drivers employed by AAA Transportation/Yellow Cab are employees and are therefore eligible for union representation. (prnewswire.com)
- The ruling is the first of its kind for taxi drivers, following a number of cases where taxi drivers were instead ruled to be independent contractors, and is in line with new analysis used in the FedEx Home Delivery, Inc. decision that found those drivers qualified as employees. (prnewswire.com)
- After filing a Request for Review, which was granted by the NLRB, the drivers sought assistance from the Office and Professional Employees International Union (OPEIU), AFL-CIO, which represents more than 4,000 taxi drivers in Las Vegas and San Diego. (prnewswire.com)
- The Office and Professional Employees International Union (OPEIU) represents more than 105,000 members in the United States , Puerto Rico and Canada , including more than 4,000 taxi drivers. (prnewswire.com)
- Téo Taxi, a Montreal-based electric taxi company, is shutting down for good - leaving some 450 drivers without work, according to the employee's union. (cbc.ca)
- MADRID (Reuters) - Spanish taxi drivers blocked major city streets including Barcelona's Gran Via and Madrid's Castellana on Monday in a protest to pressure the government to curb licences to online ride-hailing services such as Uber. (yahoo.com)
- Union representatives were due to meet officials of Prime Minister Pedro Sanchez's government later in the day to try to resolve the dispute, in which taxi drivers have choked main roads and snarled airports, bus and train stations since Saturday. (yahoo.com)
- Along with counterparts in many other European countries, Spain's taxi drivers say that ride-hailing apps have made it impossible to compete. (yahoo.com)
- Union representatives say the current law of one ride-hailing licence for every 30 taxi licences is not being respected and want an end to the practise of transferring ride-hailing permits between drivers. (yahoo.com)
Ranks8
- Taxi ranks are a vital part of London's transport network and help ensure that taxi services can meet passenger demands. (tfl.gov.uk)
- We are responsible for appointing taxi ranks on the public highway in all Greater London boroughs, with the exception of the City of London. (tfl.gov.uk)
- Cars and other vehicles parked on taxi ranks can be reported to the relevant borough, or to us if the taxi rank is on a red route, so action can be taken. (tfl.gov.uk)
- Private hire vehicles (PHVs) parked on ranks or unattended taxis on ranks should be reported directly to us so as we can take action. (tfl.gov.uk)
- These links will help you to report PHVs, unattended taxis and other vehicles on taxi ranks in London. (tfl.gov.uk)
- There are taxi ranks at key stations around the Night Tube network. (tfl.gov.uk)
- Never any taxis at the ranks, took for ever to arrive when booked and not good value. (tripadvisor.co.uk)
- There are taxi ranks on most main squares in Geneva and outside CICG. (who.int)
Borough1
- Water Taxi Beach was an artificial temporary beach operated from 2005 to 2010 on a wharf on the East River in the Hunters Point section of Long Island City , in the New York City borough of Queens . (wikipedia.org)
Fleet2
Water Taxi15
- It was operated by the New York Water Taxi Company and was open to the public for free during the summer months. (wikipedia.org)
- In concept, Water Taxi Beach is similar to Paris Beach in Paris , France . (wikipedia.org)
- [1] The beach was operated by Harry Hawk and Tony Rosciglione and partners who ran the beach owned by NY Water Taxi, now Harbor Experience Companies. (wikipedia.org)
- The restaurant Harry's at Water Taxi Beach served barbecue -type foods such as hamburgers , hot dogs , beer , wine , and tropical drinks . (wikipedia.org)
- The beach concept was created in 2005 as an experiment in community and economic development by New York Water Taxi to attract Manhattanites to Long Island City and to make weekend ferries serving the new residential high-rises near the beach financially viable. (wikipedia.org)
- The success of the beach has led New York Water Taxi to propose a similar project in Red Hook, Brooklyn . (wikipedia.org)
- Since 2007, Water Taxi Beach has been one of the main sites of the annual NYC Food Film Festival. (wikipedia.org)
- Water Taxi Beach was built and located on property owned by the Port Authority of New York and New Jersey . (wikipedia.org)
- A Wendella water taxi Thursday, July 5, 2018 on the Chicago River. (chicagotribune.com)
- Planned development along the river has led to talks between Chicago Water Taxi, part of Wendella Sightseeing, and builders about adding new stops north and south of downtown, starting in the next two to three years. (chicagotribune.com)
- Andrew Sargis, chief of operations for Chicago Water Taxi, said his company has been meeting with developers and is interested in more stops, though it wants to wait until projects are ready so it is clear what locations would be best. (chicagotribune.com)
- Right now, Chicago Water Taxi has seven stops - Ogilvie/Union Station, Michigan Avenue, LaSalle Street, the Chicago Riverwalk at Clark Street, North Avenue, Chinatown and its recently added location at Chicago Avenue. (chicagotribune.com)
- A Chicago Water Taxi, run by Wendella Sightseeing, docks at a stop near the Wrigley Building on July 5, 2018, on the Chicago River. (chicagotribune.com)
- The added residential and employment density anticipated at those sites will help build a customer base, and while the water taxi may not be the fastest option in all situations, it's a very, very pleasurable one, and that will only further the appeal of these new riverfront areas," Ellis said. (chicagotribune.com)
- Ellis said the current water taxi system is "pretty competitive" timewise with the bus or train for some routes, particularly Union Station to Chinatown or to Michigan Avenue. (chicagotribune.com)
Regulation1
- A review has been carried out and the Minister for Transport and Technical Services believes that significant change to the regulation of the taxi industry in Jersey is both desirable and necessary. (www.gov.je)
20181
- Parked taxis block a section of Paseo de la Castellana, one of Madrid's main avenues, during a strike against what they say is unfair competition from ride-hailing and car-sharing services such as Uber and Cabify in Madrid, Spain, July 30, 2018. (yahoo.com)
Lunds1
- A taxi ride to or from Lunds station costs around 100 SEK one way during weekdays. (lu.se)
Company6
- A1 Taxis are the St Alban's fastest growing Taxi Company and Couriers. (dailymotion.com)
- A1 Taxis, Your local taxi company in St Albans. (dailymotion.com)
- Menevä is the biggest family owned taxi company in Finland, serving customers nationwide and propelled by local taxi entrepreneurs. (google.com)
- Although the difficult situation of Téo Taxi had been public for some time, the announcement took several employees by surprise since they believed that the company still had a chance to be saved,' union spokesperson Stéphane Lacroix said in a statement. (cbc.ca)
- Aviation company Wisk announced yesterday that it is receiving a $450 million investment from Boeing as it works on its sixth-generation electric air taxi. (popsci.com)
- Brown says the influx of money will help them expand the company as they work on their next air taxi. (popsci.com)
Fares1
- every taxi ride, despite settling on fares (even writing it down so it was crystal clear), always ended up being an issue, i.e., more. (turkeytravelplanner.com)
City5
- Start your career as a taxi driver in the US City Hamside. (steampowered.com)
- Start your day behind the wheel of a yellow taxicab and begin your career as a taxi driver in the US City Hamside. (steampowered.com)
- State and city governments have been trying to protect the taxi industry from ridesharing services for a while, but Massachusetts is taking an unusual route. (engadget.com)
- I live in a town in Scotland that has more taxis per captia than any other town or city in Europe, and it's never difficult to get hold of a cab - but the prices are farcical at times. (kottke.org)
- A Jewish taxi driver from Holon was shot by assailants after taking an Arab passenger in to the Palestinian city of Kalkilya . (jpost.com)
Passenger1
- After our first negative experience, I took to quite visibly making a big production of my taking a smart-phone photo of the inside placard with his taxi number - this is usually on the passenger dash board and/or in the back passenger compartment (putting him on notice that we didn't want any BS). (turkeytravelplanner.com)
Istanbul2
- As I mentioned on the main Istanbul Taxi page , you cannot look forward to a good experience when using Istanbul taxis . (turkeytravelplanner.com)
- I returned from several days in Istanbul and want to mention something about the inevitable negative experience with taxis. (turkeytravelplanner.com)
Temporary3
- This will take more than 10 working days to arrange and so where a temporary taxi rank is needed you should provide as much notice as possible. (tfl.gov.uk)
- If you are holding an event then we can assist you with appointing a temporary taxi rank to help ensure that your guests can get home safely when it finishes. (tfl.gov.uk)
- Please email Taxi and Private Hire if you would like to discuss appointing a temporary taxi rank for an event in London. (tfl.gov.uk)
Taps1
- Download the app and you are always just a couple of taps of the screen away from a taxi ride. (google.com)
Electric3
- Chicago-based United Airlines said Feb. 10 it will buy up to 200 small electric air taxis to help customers get to the airport in major urban markets. (chicagotribune.com)
- Péladeau-Bisseger realized something was up when he tried access his assigned electric taxi with his key card. (cbc.ca)
- A notable competitor is Archer , which is also working on an electric air taxi. (popsci.com)
Follow1
- Also, the measures don't go as far as the taxi business might like -- Boston's Taxi Operators Association would prefer an outright ban on any ridesharing firm that doesn't follow the same rules that taxis do. (engadget.com)
Open2
- This taxi stand is centrally located and is open 24 hours. (visitbarbados.org)
- Téo Taxi clients were open to a reasonable price adjustment. (cbc.ca)
Driver6
- Chicago police have released a picture of a man who allegedly robbed a taxi driver in the Bronzeville neighborhood on the South Side earlier this week. (baltimoresun.com)
- Around 11:20 p.m. Monday in the 4600 block of South Prairie Avenue, an unknown man grabbed the 47-year-old taxi driver, implied he had a weapon and stole the driver's personal property, police said.Area Central Detectives are investigating. (baltimoresun.com)
- My friend," the driver sternly said, "This taxi is going to Sharjah. (marketplace.org)
- The taxi driver, approximately 35 years old, was shot in the shoulder and the leg, but continued to drive until he reached the Zofim checkpoint, where he alerted authorities to the incident. (jpost.com)
- The taxi driver was treated by MDA teams and taken to Meir Hospital in Kfar Saba in moderate condition. (jpost.com)
- The taxi was recovered near the checkpoint, where the taxi driver apparently parked it. (jpost.com)
Transportation2
- Its governor recently enacted a law (the first known in the US) that will charge ridesharing services a 20-cent fee for subsidizing transportation infrastructure, 5 cents of which will go to the taxi industry. (engadget.com)
- Transportation from Malmö Airport to Lund by taxi takes approximately 25 minutes and costs about 450 SEK (50 Euro). (lu.se)
Services1
- I've never understood why there's the threat of police force if you offer taxi services outside of a centrally-determined pricing structure. (kottke.org)
Sector2
- Uber and Cabify are putting the viability of the taxi sector and 130,000 jobs at risk. (yahoo.com)
- Since 2014, Austria Road Freight Volume of Taxi Operation Sector was down by 1.6% year on year. (nationmaster.com)
Ride3
- You can book a taxi straight away or prebook a ride for a later time and date. (google.com)
- Would you take a ride in a pilotless sky taxi? (bbc.com)
- 908 for an Uber Taxi Ride. (smartertravel.com)
Industry1
- Quebec's strict rules governing the taxi industry also prevented Téo from raising its rates, according Bécotte, an XPND Capital partner. (cbc.ca)
Free2
- Menevä taxis are discrimination free zones. (google.com)
- Bombay Taxi is a free parking game. (addictinggames.com)
Tours1
- Shoreline Sightseeing, known for its architecture tours, also has water taxis, though they cater to tourists more than commuters, with a shorter daily schedule, a calendar limited to the summer months and higher prices, at $6 to $10 a trip for adults. (chicagotribune.com)
Similar1
- Taxus species appear similar. (wikipedia.org)
Customers2
- Carry your customers safely and on time to their final destination, build a reputation and upgrade your Taxi. (steampowered.com)
- He is proposing increased numbers of taxis in a single taxi system (combining rank taxis and private hire), with a harmonised system of capped tariffs for customers. (www.gov.je)
China1
- Rehder, China yew Taxus contorta Griff. (wikipedia.org)
Private1
- If you have a suggestion for a new taxi rank, then you can send this to us by emailing Taxi and Private Hire . (tfl.gov.uk)
Good1
- The easiest way to get from the Lund central station to the Division of Astrophysics is to take a taxi, but if you have limited or no luggage then the 20 minute uphill walk is also a good choice. (lu.se)
Public1
- Le présent article est le dernier de trois articles de synthèse qui constituent le contexte de recherche d'une série de cinq études interdépendantes sur les modes de prescription et les erreurs de médication dans les secteurs public et privé des soins de santé primaires en Arabie saoudite. (who.int)
Rank4
- If you would like to suspend a taxi rank then you must contact us first. (tfl.gov.uk)
- All taxi rank suspension requests are considered on a case-by-case basis. (tfl.gov.uk)
- In order for us to consider your request, you must submit a fully completed taxi rank suspension form, along with any traffic management plans, to us at least 10 full working days before you would like the suspension to start. (tfl.gov.uk)
- Before you submit a request to suspend a taxi rank you must read our taxi rank suspension policy. (tfl.gov.uk)
Canada1
- Pacific yew, western yew Taxus calcicola L.M.Gao & Mich.Möller, Asian limestone yew Taxus canadensis Marshall, Canada yew Taxus chinensis (Pilg. (wikipedia.org)
Major1
- Taxis normally accept all major credit cards. (lu.se)
Delivery2
- Tuk-tuks look like a cross between a scooter and a golf cart and are used as low-cost taxis and delivery trucks. (csmonitor.com)
- Noel Sharkey, a computer scientist and robotics expert at Sheffield University, said of the drone plans: 'The big challenge will be dynamic obstacle avoidance of other taxis, buildings, birds and delivery drones. (bbc.com)