Thalamic Diseases
Disorders of the centrally located thalamus, which integrates a wide range of cortical and subcortical information. Manifestations include sensory loss, MOVEMENT DISORDERS; ATAXIA, pain syndromes, visual disorders, a variety of neuropsychological conditions, and COMA. Relatively common etiologies include CEREBROVASCULAR DISORDERS; CRANIOCEREBRAL TRAUMA; BRAIN NEOPLASMS; BRAIN HYPOXIA; INTRACRANIAL HEMORRHAGES; and infectious processes.
Maneb
Manganese Poisoning
Manganese poisoning is associated with chronic inhalation of manganese particles by individuals who work with manganese ore. Clinical features include CONFUSION; HALLUCINATIONS; and an extrapyramidal syndrome (PARKINSON DISEASE, SECONDARY) that includes rigidity; DYSTONIA; retropulsion; and TREMOR. (Adams, Principles of Neurology, 6th ed, p1213)
Zineb
Encyclopedias as Topic
Manganese
A trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035)
Facilitated Diffusion
The passive movement of molecules exceeding the rate expected by simple diffusion. No energy is expended in the process. It is achieved by the introduction of passively diffusing molecules to an enviroment or path that is more favorable to the movement of those molecules. Examples of facilitated diffusion are passive transport of hydrophilic substances across a lipid membrane through hydrophilic pores that traverse the membrane, and the sliding of a DNA BINDING PROTEIN along a strand of DNA.
Dyskinesias
Abnormal involuntary movements which primarily affect the extremities, trunk, or jaw that occur as a manifestation of an underlying disease process. Conditions which feature recurrent or persistent episodes of dyskinesia as a primary manifestation of disease may be referred to as dyskinesia syndromes (see MOVEMENT DISORDERS). Dyskinesias are also a relatively common manifestation of BASAL GANGLIA DISEASES.
An 18-mer peptide fragment of prosaposin ameliorates place navigation disability, cortical infarction, and retrograde thalamic degeneration in rats with focal cerebral ischemia. (1/96)
It was previously reported that prosaposin possesses neurotrophic activity that is ascribed to an 18-mer peptide comprising the hydrophilic sequence of the rat saposin C domain. To evaluate the effect of the 18-mer peptide on ischemic neuronal damage, the peptide was infused in the left lateral ventricle immediately after occlusion of the left middle cerebral artery (MCA) in stroke-prone spontaneously hypertensive (SP-SH) rats. The treatment ameliorated the ischemia-induced space navigation disability and cortical infarction and prevented secondary thalamic degeneration in a dose-dependent manner. In culture experiments, treatment with the 18-mer peptide attenuated free radical-induced neuronal injury at low concentrations (0.002 to 2 pg/mL), and the peptide at higher concentrations (0.2 to 20 ng/mL) protected neurons against hypoxic insult. Furthermore, a saposin C fragment comprising the 18-mer peptide bound to synaptosomal fractions of the cerebral cortex, and this binding decreased at the 1st day after MCA occlusion and recovered to the preischemic level at the 7th day after ischemia. These findings suggest that the 18-mer peptide ameliorates neuronal damage in vivo and in vitro through binding to the functional receptor, although the cDNA encoding prosaposin receptor has not been determined yet. (+info)Bilateral enhancing thalamic lesions in a 10 year old boy: case report. (2/96)
A young boy presented with monoparesis of the left arm. MRI disclosed bilateral enhancing thalamic lesions. Biopsy results and subsequent clinical history were most compatible with postinfectious or acute disseminated encephalomyelitis. This represents one of the first cases of acute disseminated encephalomyelitis affecting the thalami, established by biopsy. This uncommon disease entity is reviewed and how it may affect the deep grey matter is described. (+info)MR spectroscopy of bilateral thalamic gliomas. (3/96)
This study reports the MR spectroscopic patterns of two patients with bithalamic glioma. In one patient, phosphorus (31P) MR spectroscopy was performed. In both patients, the proton MR spectroscopic scans showed an increased creatine-phosphocreatine peak in the tumor. In the patient who underwent 31P-MR spectroscopy, an increased phosphocreatine peak was also observed. This group of thalamic tumors may be distinguished from other gliomas clinically, radiologically, and metabolically. (+info)A case of thalamic syndrome: somatosensory influences on visual orientation. (4/96)
The ability to set a straight line to the perceived gravitational vertical (subjective visual vertical, SVV) was investigated in a 21 year old woman with long standing left hemihypaesthesia due to a posterior thalamic infarct. The putative structures involved were the somatosensory and vestibular thalamus (VPL, VPM) and associative (pulvinar) thalamus. The SVV was normal when seated upright. When lying on her right side, line settings deviated about 17 degrees to the right, which is the normal A-effect. When lying on the hypaesthetic side the mean SVV remained close to true vertical-that is, the A-effect was absent, and there was a large increase in variability of the SVV settings. The findings support the view that the body tilt-induced bias of the SVV (A-effect) is largely mediated by somatosensory afferents. The finding that the A-effect was absent only when lying on the hypaesthetic side suggests that, during body tilt, the somatosensory system participates in visuogravitational orientation. (+info)The clinical efficacy of neuroendoscope in surgical treatment for deafferentation pain. (5/96)
Spinal cord stimulation (SCS) is one of the most minimally invasive and effective treatments for intractable pain. We report the efficacy of a very small diameter neuroendoscope on setting the electrode to the proper site in the epidural space. Our cases include thalamic hemorrhage, and each patient had unilateral intractable pain on L1 or less as the main complaint. They had been treated for over two years in other hospitals, but no significant relief was achieved. Because each patient had been given frequent epidural blocks, the adhesion in the epidural space was expected. In Group A (3 cases), we used very small diameter neuroendoscope to dissect adhesion in the epidural space and to make optimal space for lead placement under direct vision. Conventional lead placement under fluoroscopy was performed in Group B (3 cases). Medtronic's PISCES lead system was used for SCS. In Group A, stimulation and pain regions matched in all cases, and good pain relief was also achieved. In Group B, however, stimulation and pain regions matched incompletely and the increase in stimulation caused stimulation on the pain-free side. (+info)Bilateral simultaneous thalamic hemorrhages--case report. (6/96)
A 54-year-old male presented with bilateral simultaneous thalamic hemorrhages manifesting as semicoma, tetraplegia, and skew deviation. Magnetic resonance imaging and angiography demonstrated no lesions responsible for the bleeding. Coagulant factors were within normal ranges. The cause of these hemorrhages was considered to be hypertension. Conservative treatment was performed. He was discharged with serious neurological deficits. (+info)Influenza A-associated encephalopathy with bilateral thalamic necrosis in Japan. (7/96)
Two cases of acute encephalopathy in young children clearly showed evidence of influenza A virus infection and bilateral thalamic lesions. Influenza-associated encephalopathy with bilateral thalamic lesions has mostly been reported in Japan; it differs from Reye's syndrome in several respects. Other factors in addition to influenza virus infection may have contributed to the etiology of encephalopathy in our case patients. (+info)Preoperative shunts in thalamic tumours. (8/96)
Thirty one patients with thalamic glioma underwent a pre-tumour resection shunt surgery. The procedure was uneventful in 23 patients with relief from symptoms of increased intracranial pressure. Eight patients worsened after the procedure. The level of sensorium worsened from excessively drowsy state to unconsciousness in seven patients. Three patients developed hemiparesis, 4 developed paresis of extra-ocular muscles and altered pupillary reflexes, and 1 developed incontinence of urine and persistent vomiting. Alteration in the delicately balanced intracranial pressure and movements in the tumour and vital adjacent brain areas could be the probable cause of the worsening in the neurological state in these 8 patients. On the basis of these observations and on review of literature, it is postulated that the ventricular dilatation following an obstruction in the path of the cerebrospinal fluid flow by a tumour could be a natural defense phenomenon of the brain. (+info)Thalamic diseases refer to a group of disorders that primarily affect the thalamus, a part of the brain that serves as a relay station for sensory and motor signals, and can cause various symptoms such as sensory loss, motor dysfunction, cognitive impairment, and altered consciousness.
Thalamic diseases refer to conditions that affect the thalamus, which is a part of the brain that acts as a relay station for sensory and motor signals to the cerebral cortex. The thalamus plays a crucial role in regulating consciousness, sleep, and alertness. Thalamic diseases can cause a variety of symptoms depending on the specific area of the thalamus that is affected. These symptoms may include sensory disturbances, motor impairment, cognitive changes, and altered levels of consciousness. Examples of thalamic diseases include stroke, tumors, multiple sclerosis, infections, and degenerative disorders such as dementia and Parkinson's disease. Treatment for thalamic diseases depends on the underlying cause and may include medications, surgery, or rehabilitation therapy.
Maneb is a fungicide from the class of dithiocarbamates, which is used to control various plant diseases, but its use is restricted due to potential health risks including neurotoxicity and potential endocrine disruption.
Maneb is not a term that has a widely accepted medical definition. However, in the field of agriculture and toxicology, Maneb is a commonly used fungicide to control various plant diseases. It is a complex organometallic compound containing manganese.
In some contexts, Maneb may be mentioned in relation to human health because it has been found to have potential reproductive and developmental effects, as well as being potentially carcinogenic. However, it is not considered a medical term or diagnosis. If you have any concerns about exposure to Maneb or its potential health effects, it would be best to consult with a healthcare professional.
Manganese poisoning, also known as manganism, is a neurological disorder caused by excessive exposure to manganese, characterized by symptoms such as Parkinsonian-like movement disorders, cognitive impairment, and psychiatric disturbances.
Manganese poisoning, also known as manganism, is a condition that results from excessive exposure to manganese. Manganese is an essential nutrient, but at high levels, it can become toxic to the body. The symptoms of manganese poisoning can be similar to those of Parkinson's disease and may include tremors, difficulty walking, and mood changes. In severe cases, manganese poisoning can lead to irreversible neurological damage. Exposure to manganese can occur through inhalation, ingestion, or skin contact, and is often associated with occupational exposure in industries such as welding, mining, and manufacturing of batteries and fertilizers.
Zineb is a fungicide from the class of dithiocarbamates, used to control various fungal diseases in crops such as grapes, vegetables, and ornamental plants, with the chemical formula (C4H4N2S4)n.
I apologize for any confusion, but "Zineb" is not a medical term or concept that I am familiar with in the field of medicine. Zineb is actually a pesticide that contains the active ingredient ferbam, which is used to control fungi on crops such as grapes, apples, and potatoes. It is not a term used within the context of medical definitions or human health. I hope this clarifies any confusion. If you have any questions related to medicine or healthcare, I would be happy to try and help answer them for you.
"Encyclopedias, as a medical topic, refer to comprehensive and organized collections of information on various medical disciplines, theories, practices, diseases, treatments, and related health sciences, serving as extensive reference sources for medical professionals, students, researchers, and general public." (29 words)
An encyclopedia is a comprehensive reference work containing articles on various topics, usually arranged in alphabetical order. In the context of medicine, a medical encyclopedia is a collection of articles that provide information about a wide range of medical topics, including diseases and conditions, treatments, tests, procedures, and anatomy and physiology. Medical encyclopedias may be published in print or electronic formats and are often used as a starting point for researching medical topics. They can provide reliable and accurate information on medical subjects, making them useful resources for healthcare professionals, students, and patients alike. Some well-known examples of medical encyclopedias include the Merck Manual and the Stedman's Medical Dictionary.
Manganese is an essential trace element that functions as a co-factor for various enzymes, including manganese superoxide dismutase, arginase, and pyruvate carboxylase, involved in different physiological processes such as antioxidant defense, protein metabolism, and energy production.
Manganese is not a medical condition, but it's an essential trace element that is vital for human health. Here is the medical definition of Manganese:
Manganese (Mn) is a trace mineral that is present in tiny amounts in the body. It is found mainly in bones, the liver, kidneys, and pancreas. Manganese helps the body form connective tissue, bones, blood clotting factors, and sex hormones. It also plays a role in fat and carbohydrate metabolism, calcium absorption, and blood sugar regulation. Manganese is also necessary for normal brain and nerve function.
The recommended dietary allowance (RDA) for manganese is 2.3 mg per day for adult men and 1.8 mg per day for adult women. Good food sources of manganese include nuts, seeds, legumes, whole grains, green leafy vegetables, and tea.
In some cases, exposure to high levels of manganese can cause neurological symptoms similar to Parkinson's disease, a condition known as manganism. However, this is rare and usually occurs in people who are occupationally exposed to manganese dust or fumes, such as welders.
Facilitated diffusion is a type of passive transport that involves the process of specific proteins, called transporters or channels, assisting in the movement of molecules or ions across the cell membrane from an area of higher concentration to a lower concentration, without requiring energy input, while still maintaining a degree of substrate specificity and transport rate regulation.
Facilitated diffusion is a type of passive transport that involves the movement of molecules or ions across a biological membrane with the assistance of a transport protein. Unlike simple diffusion, which occurs spontaneously down a concentration gradient, facilitated diffusion allows for the movement of substances against a concentration gradient, although it does not directly consume energy.
In facilitated diffusion, the transport protein binds to the substance (also known as the solute) on one side of the membrane and then changes shape, releasing the solute on the other side. This process can increase the rate of diffusion by providing a more efficient pathway for the solute to move through the membrane.
Examples of substances that use facilitated diffusion include glucose, amino acids, and ions such as sodium and potassium. These substances are too large or too polar to pass through the hydrophobic interior of the lipid bilayer that makes up the cell membrane, so they rely on transport proteins to help them move across the membrane.
It's important to note that facilitated diffusion is a passive process and does not require energy input from the cell. However, it is a regulated process, as the number of transport proteins in the membrane can be adjusted to control the rate of solute movement.
Dyskinesias are involuntary, irregular, and often repetitive movements that can affect various parts of the body, typically caused by disorders in the basal ganglia region of the brain or as a side effect of long-term use of certain medications like levodopa in Parkinson's disease.
Dyskinesias are a type of movement disorder characterized by involuntary, erratic, and often repetitive muscle movements. These movements can affect any part of the body and can include twisting, writhing, or jerking motions, as well as slow, writhing contortions. Dyskinesias can be caused by a variety of factors, including certain medications (such as those used to treat Parkinson's disease), brain injury, stroke, infection, or exposure to toxins. They can also be a side effect of some medical treatments, such as radiation therapy or chemotherapy.
Dyskinesias can have a significant impact on a person's daily life, making it difficult for them to perform routine tasks and affecting their overall quality of life. Treatment for dyskinesias depends on the underlying cause and may include medication adjustments, surgery, or physical therapy. In some cases, dyskinesias may be managed with the use of assistive devices or by modifying the person's environment to make it easier for them to move around.
Parkinsonism
Halliday, Glenda M. (2009-12-15). "Thalamic changes in Parkinson's disease". Parkinsonism & Related Disorders. 15: S152-S155. ... Frontotemporal dementia (Pick's disease) Gerstmann-Sträussler-Scheinker syndrome Huntington's disease Lytico-bodig disease (ALS ... hereditary juvenile dystonia Parkinson's disease Parkinson's disease dementia Progressive supranuclear palsy Wilson's disease X ... "Role of neuroimaging on differentiation of Parkinson's disease and its related diseases". Yonago Acta Med (Review). 61 (3): 145 ...
Paroxysmal kinesigenic choreoathetosis
It is not fully known, however, what role a thalamic abnormality plays in the disease pathophysiology. Paroxysmal kinesigenic ... The first gene to be identified was the PRRT2 gene on chromosome 16, found in 2011 to be the cause of the disease in some ... Finally in a review in 1995 Demirkiran and Jankovic stated the disease should be called paroxysmal kinesigenic dyskinesia ... Zhou, B.; Chen, Q.; Gong, Q.; Tang, H.; Zhou, D. (2009). "The thalamic ultrastructural abnormalities in paroxysmal kinesigenic ...
Pain and pleasure
"Unilateral thalamic deep brain stimulation for refractory essential tremor and Parkinson's disease tremor". Neurology. 51 (4): ... So far, DBS has been recognized as a treatment for Parkinson's disease, tremors, and dystonia by the Food and Drug ... The following neurological and/or mental diseases have been linked to forms of pain or anhedonia: schizophrenia, depression, ... Braithwaite, V.A.; Boulcott, P. (2007). "Pain perception, aversion and fear in fish" (PDF). Diseases of Aquatic Organisms. 75 ( ...
Intralaminar thalamic nuclei
"Loss of thalamic intralaminar nuclei in progressive supranuclear palsy and Parkinson's disease: clinical and therapeutic ... The intralaminar thalamic nuclei (ITN) are collections of neurons in the internal medullary lamina of the thalamus that are ... Diagram at University of Florida v t e (Articles with TA98 identifiers, Thalamic nuclei, All stub articles, Neuroanatomy stubs) ... Maxwell, William L.; MacKinnon, Mary Anne; Smith, Douglas H.; McIntosh, Tracy K.; Graham, David I. (2006). "Thalamic Nuclei ...
Centromedian nucleus
"Loss of thalamic intralaminar nuclei in progressive supranuclear palsy and Parkinson's disease: clinical and therapeutic ... Unilateral lesions can lead to unilateral thalamic neglect. A patient with electrodes implanted into more than 50 different ... is a part of the intralaminar thalamic nuclei (ITN) in the thalamus. There are two centromedian nuclei arranged bilaterally. In ...
Benton Visual Retention Test
Dementia, brain lesions, thalamic stroke, and Alzheimer's disease are among the conditions that have been shown to greatly ... The Benton Test is sensitive to many forms of brain impairments and diseases, but it is difficult to diagnose a particular ... disease through the test. In fact, according to the test manual, a high number of a single category of error should not be used ...
Thalamocortical dysrhythmia
It was also proposed that psychotic disorders present in Parkinson disease‐dementia with Lewy bodies depend on thalamic ... At the base of the theory lies diminished excitatory or increased inhibitory input at the thalamic level. This leads to a ... means of lesioning small parts of the central lateral thalamic areas has proven successful as a therapy for Parkinson's Disease ... The thalamic loss of input or gated activity allows the frequency of the thalamo-cortical column to slow into the theta or ...
List of MeSH codes (C10)
... thalamic diseases MeSH C10.228.228.090 - brain abscess MeSH C10.228.228.090.800 - toxoplasmosis, cerebral MeSH C10.228.228.180 ... lewy body disease MeSH C10.228.140.079.862.500 - parkinson disease MeSH C10.228.140.079.862.800 - parkinson disease, secondary ... lewy body disease MeSH C10.228.662.600.400 - parkinson disease MeSH C10.228.662.600.700 - parkinson disease, secondary MeSH ... lewy body disease MeSH C10.228.140.380.615 - pick disease of the brain MeSH C10.228.140.400 - diffuse cerebral sclerosis of ...
Salience network
Cortico-striatal-thalamic loop circuits contribute to the salience network. While the function of the salience network is not ... and Alzheimer's disease. The AI node of the salience network has been observed to be hyperactive in anxiety disorders, which is ... Peters, SK; Dunlop, K; Downar, J (2016). "Cortico-Striatal-Thalamic Loop Circuits of the Salience Network: A Central Pathway in ... Psychiatric Disease and Treatment". Frontiers in Systems Neuroscience. 10: 104. doi:10.3389/fnsys.2016.00104. PMC 5187454. PMID ...
Blocq's disease
This specific disinhibition enables movement initiation, by releasing excitatory thalamic neurons. Ventral striatum ... its dysfunction has been related in some diseases such as Parkinson's disease and movement disorders. Striatum is a subcortical ... Diseases that affect the vestibular system such as gait disorders often impair the initiation of a movement. Most of the ... Blocq's disease was first considered by Paul Blocq (1860-1896), who described this phenomenon as the loss of memory of ...
Creutzfeldt-Jakob disease
"Thalamic involvement in sporadic Creutzfeldt-Jakob disease: a diffusion-weighted MR imaging study". AJNR. American Journal of ... Creutzfeldt-Jakob disease @ Who Named It "Creutzfeldt-Jakob Disease, Classic (CJD) , Prion Diseases , CDC". www.cdc.gov. 1 ... These neurodegenerative diseases are commonly called prion diseases. People can also develop CJD because they carry a mutation ... "Creutzfeldt-Jakob Disease, Classic (CJD) , Prion Diseases". CDC. 6 February 2015. Archived from the original on 18 July 2017. ...
Joshua B. Bederson
Bederson is co-author of Treatment of Carotid Disease: A Practitioner's Manual (ISBN 1-879284-55-3), 12 chapters and 53 peer- ... "Clinical improvement related to thrombolysis of third ventricular blood clot in a patient with thalamic hemorrhage." J Stroke ... "Clinical improvement related to thrombolysis of third ventricular blood clot in a patient with thalamic hemorrhage." Journal of ... "Patient Selection for Carotid Endarterectomy." In: Bederson JB, Tuhrim S, (eds), Treatment of Carotid Disease: A Practitioner's ...
Thalamic stimulator
A thalamic stimulator is a medical device that can suppress tremors, such as those caused by Parkinson's disease or essential ... It is notable that the presence of thalamic stimulators significantly changes ECG patterns, and prevents the use of MRI. It is ... Differential electrocardiographic artifact from implanted thalamic stimulator FDA Okays Powerful Brain Implant Washington ...
Parkinson's disease
DBS of the globus pallidus interna improves motor function, while DBS of the thalamic DBS improves tremor, but has little ... Parkinson's disease dementia becomes common in advanced stages of the disease. The motor symptoms of the disease result from ... Some autoimmune diseases may even increase one's risk of developing PD, up to 33% in one study. Autoimmune diseases linked to ... The stage of the disease and the age at disease onset determine which group is most useful. Braak staging of PD uses six stages ...
List of diseases (T)
Tetrasomy X Thakker-Donnai syndrome Thalamic degeneration symmetrical infantile Thalamic degenerescence infantile Thalamic ... This is a list of diseases starting with the letter "T" with syptoms similar to seizures. Diseases Alphabetical list 0-9 A B C ... gestational trophoblastic disease) Trophoblastic tumor Tropical spastic paraparesis Tropical sprue Troyer syndrome Trueb-Burg- ... Todd's paralysis Todd's syndrome Togaviridae disease Tollner-Horst-Manzke syndrome Tolosa-Hunt syndrome Toluene antenatal ...
List of diseases (I)
... osteomyolitis Infantile sialic acid storage disorder Infantile spasms broad thumbs Infantile spasms Infantile striato thalamic ... This is a list of diseases starting with the letter "I". Diseases Alphabetical list 0-9 A B C D E F G H I J K L M N O P Q R S T ... type A Intercellular cholesterol esterification disease Interferon gamma, receptor 1, deficiency Internal carotid agenesis ... familial Infantile digital fibromatosis Infantile dysphagia Infantile multisystem inflammatory disease Infantile ...
List of diseases (S)
Sybert-Smith syndrome Sydenham's chorea Symmetrical thalamic calcifications Symphalangism brachydactyly craniosynostosis ... This is a list of diseases starting with the letter "S". Diseases Alphabetical list 0-9 A B C D E F G H I J K L M N O P Q R S T ... hemangiomas Suriphobia Susac syndrome Sutherland-Haan syndrome Sutton disease II Sutton disease II Sweeley-Klionsky disease ... disorder Schamberg's disease Scheie syndrome Schereshevskij Turner Scheuermann's disease Schimke syndrome Schindler disease ...
Low-threshold spikes
Thalamic relay cells show two types of responses. One response mode is a relay or tonic mode, in which the cell is depolarized ... Hypo-bradykinesia, as seen in Parkinson's disease, is improved by medial thalamotomy; this suggests that it is caused by ... All thalamic relay cells experience these specific voltage-dependent calcium currents, and the cat has proven to be a useful ... Low-threshold calcium spikes have been described in neurons from a variety of brain nuclei, including the thalamic relay, ...
Demyelinating disease
... deep brain thalamic stimulation (to ameliorate tremors).: 227-248 Prognosis depends on the condition itself. Some conditions ... A demyelinating disease refers to any disease affecting the nervous system where the myelin sheath surrounding neurons is ... Demyelinating diseases are traditionally classified into two types: demyelinating myelinoclastic diseases and demyelinating ... The Poser criteria named this second group dysmyelinating diseases. In the most well-known demyelinating disease, multiple ...
Astasis
The two are most commonly seen in astasia-abasia, which is also called Blocq's disease. It is more common for astasia and ... Astasis has been seen in patients with diverse thalamic lesions, predominantly affecting the posterior lateral region of the ... Since astasis itself is more a symptom than a disease, it is more often seen associated with other signs and symptoms. People ... This balance impairment is similar to patients with vestibulocerebellar syndrome, which is a progressive neurological disease ...
Hans Hoff (psychiatrist)
... thalamic and cerebellum, time lapse phenomena, nervous vascular regulation, sleep studies, adrenal disturbances in infectious ... diseases, epilepsy, multiple sclerosis, psychopathy, and alcoholism. In addition to his scientific research, Hoff did pioneer ...
Nystagmus
Canavan disease COVID-19 Head trauma Lateral medullary syndrome Ménière's disease and other balance disorders Multiple ... Cerebellar ataxia Chiari malformation Multiple sclerosis Stroke Thalamic hemorrhage Trauma Tumor Infantile cerebellar retinal ... Some of the diseases that present nystagmus as a pathological sign or symptom are as follows: Aniridia Benign paroxysmal ... An example of disease state in which this occurs is benign paroxysmal positional vertigo (BPPV). Post rotational nystagmus ...
Stereotactic surgery
From then on, thalamic lesions became the target point with more satisfactory results. More recent clinical applications can be ... Functional disorders are: trigeminal neuralgia, Parkinson's disease, and epilepsy. Stereotactic surgery works on the basis of ... Functional neurosurgery comprises treatment of several disorders such as Parkinson's disease, hyperkinesia, disorder of muscle ... and are affected by Parkinson's disease. The electrode is connected to a small battery operated stimulator that is placed under ...
Akinetic mutism
... a rare degenerative brain disease) and can help diagnose patients with this disease. It can also occur in a stroke that affects ... Many cases of akinetic mutism occur after a thalamic stroke. The thalamus helps regulate consciousness and alertness.[citation ... It often occurs after brain injury or as a symptom of other diseases. Akinetic mutism is often the result of severe frontal ... Creutzfeldt-Jakob disease (mesencephalic form) Akinetic mutism can be misdiagnosed as depression, delirium, or locked-in ...
James B. Preston
In: Motor Control in Health and Disease. Ed., Desmedt, J.E. Raven Press, NY, 1983. Holsapple, J.W., Preston, J.B., and Strick, ... P.L. The origin of thalamic inputs to the "hand" representation in the primary motor cortex. Journal of Neuroscience 11: 2644- ...
Oculogyric crisis
... bilateral thalamic infarction, lesions of the fourth ventricle, cystic glioma of the third ventricle, herpes encephalitis, ... kernicterus and juvenile Parkinson's disease. Patients with procyclidine addiction or craving may simulate signs of ...
Intention tremor
This disease affects the proximal muscles of the head, shoulders, and neck. Tremors of this disease occur at frequencies of 2-4 ... Deep brain stimulation and surgical lesioning of the thalamic nuclei has been found to be an effective long-term treatment with ... Wilson's disease, Creutzfeldt-Jakob disease, Guillain-Barré syndrome, and fragile X syndrome, as well as brain tumors, low ... The disease often destroys physical and cognitive function of individuals.[citation needed] Intention tremors can be a first ...
Expressive aphasia
Alzheimer's disease may present with either fluent aphasia or expressive aphasia. There are case reports of Creutzfeldt-Jakob ... Orzeren, A; F Koc; M Demirkiran; A Sonmezler (2006). "Global aphasia due to left thalamic hemorrhage". Neurology India. 54 (4 ... Mahboob, Hafiz B.; Kaokaf, Kazi H.; Gonda, Jeremy M. (2018-02-14). "Creutzfeldt-Jakob Disease Presenting as Expressive Aphasia ... Brain tumor Brain trauma Autoimmune disease Paraneoplastic syndrome Micrometastasis neurodegenerative disorders Certain ...
Neuromodulation (medicine)
For Parkinson's disease central nervous system targets include the subthalamic nucleus, globus pallidus interna, and the ... Dystonias are often treated by implants targeting globus pallidus interna, or less often, parts of the ventral thalamic group. ... Disease states and conditions that have been discussed as targets for future electroceutical therapy include diabetes, ... Ultimately, the electroceuticals quest aims to find the electro-neural signature of disease and at a cellular level, in real ...
Yunis-Varon syndrome
"Yunis-Varon syndrome". Disease Information from NORD, National Organization for Rare Disorders, Inc. Corona-Rivera JR, Romo- ... Intraneural inclusions (bodies within neural cells) with vacuolar degeneration are prominent mostly in the patient's thalamic ... These deformities in addition to microcephaly and reduced ossification from the disease might be partially due to the affected ... Some mutations lead to various forms of Charcot-Marie-Tooth disease, Amyotrophic lateral sclerosis 11, and bilateral ...
CRCNS: Propagation of beta oscillations in cortico-basal ganglia-thalamic loop - JPND Neurodegenerative Disease Research
... loop has been implicated in disorders of importance to public health including Parkinsons disease, Huntingtons disease, ... their dysfunction in Parkinsons disease but also the role they play in other disorders of the cortico-basal ganglia-thalamic ... They propose to extend this model to include mathematical models of each of the nuclei of the cortico-basal ganglia-thalamic ... It is estimated that 5 million people worldwide have Parkinsons disease, and this number is projected to reach 8.7 million by ...
ISMRM 2022) Thalamic volume and lateralization on Parkinson Disease associated with cognitive and motor deficits
Thalamic volume and lateralization on Parkinson Disease associated with cognitive and motor deficits. Vicente Jose Ferrer- ... thalamic variance neuroscience brain disease contributing anterior reflected interrogated digit relationship motor variables ... Cognitive deficits in semantic fluency and symbols and digits tests in PD are related to ventral, central and medial thalamic ... This study sheds light on the relationship between the thalamic nuclei volume and their lateralization with cognitive and motor ...
Parkinsonism - Wikipedia
Halliday, Glenda M. (2009-12-15). "Thalamic changes in Parkinsons disease". Parkinsonism & Related Disorders. 15: S152-S155. ... Frontotemporal dementia (Picks disease) Gerstmann-Sträussler-Scheinker syndrome Huntingtons disease Lytico-bodig disease (ALS ... hereditary juvenile dystonia Parkinsons disease Parkinsons disease dementia Progressive supranuclear palsy Wilsons disease X ... "Role of neuroimaging on differentiation of Parkinsons disease and its related diseases". Yonago Acta Med (Review). 61 (3): 145 ...
Posterior Cerebral Artery Stroke: Background, Anatomy, Pathophysiology
Isolated lateral thalamic infarction: the role of posterior cerebral artery disease. Eur J Neurol. 2012 Feb. 19(2):265-70. [ ... Proximal vertebrobasilar artery disease. Atheromatous disease may be found within the vertebral artery in patients with ... Paramedian thalamic infarction. This syndrome results from bilateral medial thalamic infarction. The presentation in these ... Intrinsic basilar atheromatous disease may result in misery perfusion or artery-to-artery embolization in the PCA distribution. ...
Improvement of levodopa induced dyskinesias by thalamic deep brain stimulation is related to slight variation in electrode...
1993) Chronic thalamic stimulation improves tremor and levodopa induced dyskinesias in Parkinsons disease. J Neurol Neurosurg ... 1994) Long-term thalamic stimulation in Parkinsons disease: postmortem anatomo-clinical study. Neurology 44:1856-1860. ... 1987) Combined (thalamotomy and stimulation) stereotactic surgery of the Vim thalamic nucleus for bilateral Parkinson disease. ... 1987) In : Fahn S, Marsden CD, Calne D, et al eds. Recent developments in Parkinsons disease. (Mac Millan HI, New Jersey), 2: ...
Publications
... the Anatomy and Microstructure of the Dentato-rubro-thalamic and Subthalamo-ponto-cerebellar Tracts in Parkinsons Disease. ... The impact of genetic risk for Alzheimers disease on the structural brain networks of young adults. Frontiers in Neuroscience ... The ENIGMA-Epilepsy working group: mapping disease from large data sets. Human Brain Mapping 43 (1), pp.113-128. (10.1002/hbm. ... HD-DRUM - a novel computerised drumming training for movement and cognitive abilities in people with Huntingtons disease - app ...
Deep Brain Stimulation for Gait and Postural Disturbances in Parkinson's Disease | SpringerLink
Parkinsons disease (PD) is a progressive neurodegenerative disorder characterized by distal (i.e., tremor, bradykinesia, and ... subthalamic nucleus deep brain stimulation reverses cortico-thalamic coupling during voluntary movements in Parkinsons disease ... H.J. Lee, W.W. Lee, S.K. Kim, H. Park, H.S. Jeon, H.B. Kim, et al., Tremor frequency characteristics in Parkinsons disease ... N.I. Bohnen, K.A. Frey, S. Studenski, V. Kotagal, R.A. Koeppe, P.J.H. Scott, et al., Gait speed in Parkinson disease correlates ...
Überwindung des "Homo oeconomicus" | Max-Planck-Institut für Kognitions- und Neurowissenschaften
... the anatomy and microstructure of the dentato-rubro-thalamic and subthalamo-ponto-cerebellar tracts in Parkinsons disease. ... Jandric, D.; Lipp, I.; Castellazzi, G.; Parker, G. J. M.; Tomassini, V.; Muhlert, N.: The role of disease duration in ... A critical review of white matter changes in Huntingtons disease. Movement Disorders 35 (8), S. 1302 - 1311 (2020) ...
Connecting white matter injury and thalamic atrophy in clinically isolated syndromes
Previous studies suggest that thalamic degeneration is prominent in multiple sclerosis (MS) and even in pre-MS patients ... Demyelinating Diseases / pathology* * Diffusion Magnetic Resonance Imaging / methods * Female * Humans * Imaging, Three- ... Connecting white matter injury and thalamic atrophy in clinically isolated syndromes J Neurol Sci. 2009 Jul 15;282(1-2):61-6. ... Previous studies suggest that thalamic degeneration is prominent in multiple sclerosis (MS) and even in pre-MS patients ...
Plus it
Thalamic atrophy in multiple sclerosis: a magnetic resonance imaging marker of neurodegeneration throughout disease. Ann Neurol ... prediction of disease progression, and monitoring and prediction of the response to disease-modifying treatments.1 Actually, ... it is common to acquire brain and spinal cord MR imaging sequences separately to assess the extent of the disease. The goal of ... qualitative and quantitative assessment of both the brain and the spinal cord is important for diagnosis and monitoring disease ...
Table 2 - Characterization of Sporadic Creutzfeldt-Jakob Disease and History of Neurosurgery to Identify Potential Iatrogenic...
MM2-thalamic type sporadic CJD; ND, not done; PRNP, prion protein gene; Th, thalamus.. †Disease duration is the time between ... The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. ... Disease duration, mo†. Codon 129 of PRNP. Lesions on DW-MRI. Pathology findings. ... Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting People ...
Identification and validation of oxidative stress and immune-related hub genes in Alzheimer's disease through bioinformatics...
Alzheimers disease (AD) is the leading cause of dementia in aged population. Oxidative stress and neuroinflammation play ... Aggleton, J. P., Pralus, A., Nelson, A. J. & Hornberger, M. Thalamic pathology and memory loss in early Alzheimers disease: ... Alzheimers disease (AD) is an insidious, progressive, and devastating neurodegenerative disease, which is recognized as the ... Efthymiou, A. G. & Goate, A. M. Late onset Alzheimers disease genetics implicates microglial pathways in disease risk. Mol. ...
Tremor - Neurologic Disorders - MSD Manual Professional Edition
In Parkinson disease, tremor substantially lessens after thalamic, internal globus pallidus, or subthalamic nucleus deep brain ... or Wilson disease Wilson Disease Wilson disease results in accumulation of copper in the liver and other organs. Hepatic or ... Serum ceruloplasmin and urinary copper levels should be measured to check for Wilson disease Wilson Disease Wilson disease ... Muscle rigidity, gait and postural problems, and slowness of movement: Parkinson disease Parkinson Disease Parkinson disease is ...
Pathophysiology of Motor Dysfunction in Parkinson's Disease as the Rationale for Drug Treatment and Rehabilitation
... which appear in the early stages of the disease and largely depend on dopaminergic nigrostriatal denervation. Intermediate and ... s disease (PD) include bradykinesia, rest tremor, and rigidity, ... ventrolateral thalamic nucleus, and pallidum) or the CTC (VIM) ... L. V. Kalia, S. K. Kalia, and A. E. Lang, "Disease-modifying strategies for Parkinsons disease," Movement Disorders, vol. 30, ... Parkinsons disease (PD) is the second most common neurodegenerative disorder after Alzheimers disease (AD), with an overall ...
Deep brain stimulation changes rhythms to treat Parkinson's disease and tremor | ScienceDaily
Deep brain stimulation may stop uncontrollable shaking in patients with Parkinsons disease and essential tremor by imposing ... Short latency activation of cortex by clinically effective thalamic brain stimulation for tremor. Movement Disorders, 2012; DOI ... Deep brain stimulation changes rhythms to treat Parkinsons disease and tremor. Date:. August 28, 2012. Source:. University of ... In these diseases, an effective dose measurement could be especially useful in optimizing DBS therapy. ...
Elimination of huntingtin in the adult mouse leads to progressive behavioral deficits, bilateral thalamic calcification, and...
To date there is no cure for Huntingtons Disease, and current therapeutic strategies are only palliative, and far from optimal ... However, since normal and mutant huntingtin (the protein product of the Huntingtons disease gene) differ only on the ... Gene silencing currently appears as the most attractive approach for the treatment of Huntingtons Disease. ... Author summary Huntingtons Disease is a genetic disorder characterized by progressive cognitive, behavioral and motor ...
Survival and functional outcomes in paediatric thalamic and thalamopeduncular low grade gliomas
Seven patients were without evidence of disease, 6 had stable disease, 7 stable following progression and 1 had progressive ... Disease progression was observed in 9 patients (median progression-free survival 7.3 years). At last follow-up (median 6.1 ... Survival and functional outcomes in paediatric thalamic and thalamopeduncular low grade gliomas Acta Neurochir (Wien). 2022 Jun ... disease managed expectantly. Conclusion: Paediatric patients with low-grade thalamopeduncular gliomas have excellent long-term ...
Prosaposin maintains lipid homeostasis in dopamine neurons and counteracts experimental parkinsonism in rodents | Nature...
Prosaposin (PSAP) variants are linked to Parkinsons disease (PD). Here, the authors report PSP changes in PD and lipid ... modulates glycosphingolipid metabolism and variants have been linked to Parkinsons disease (PD). Here, we find altered PSAP ... shift in midbrain dopaminergic projections and increased thalamic/raphe serotonergic function in early Parkinson disease. J. ... Cenci, M. A. & Widner, H. Parkinson disease: poor results for retinal cell transplants in Parkinson disease. Nat. Rev. Neurol. ...
帕金森综合征 - 医生与科室 - 妙佑医疗
Parkinsons disease, Tourette syndrome, Facial pain disorder, Thalamic pain, Epilepsy, Mesial temporal sclerosis, DYT1 dystonia ... Motor neuron disease, Muscle atrophy, Sacroiliac pain syndromes, Radiculopathy, Charcot-Marie-Tooth disease, Spasticity, Lumbar ... Grand mal seizure, Dementia, Primary lateral sclerosis, Migraine with aura, Parkinsons disease, Absence seizure, Amyot... ... Electroconvulsive therapy, Deep brain stimulation, Narcolepsy, Sleep disorders, Alcohol use disorder, Parkinsons disea...se ...
speech perception; Speech Discrimination
A similarity measure between symptoms and diseases is provided. ... Ranked list of possible diseases from either several symptoms ... Thalamic Diseases. 1. + + We do not evaluate or guarantee the accuracy of any content in this site. Click here for the full ... Diseases. Frequent searches. Medicinal plants. Health topics. Medical dictionary. Health sites. Questions and answers. ...
MHI Newest Research | MH Insights
Frontiers | Fixel-Based Analysis Effectively Identifies White Matter Tract Degeneration in Huntington's Disease
Diffusion weighted images were acquired from 12 patients with Huntingtons Disease and 12 healthy unrelated controls using a 3 ... Fixel-based analysis is effective in studying white matter tractography and fiber changes in Huntingtons Disease. ... Microstructure damage in white matter might be linked to regional and global atrophy in Huntington Disease. We hypothesize that ... Microstructure damage in white matter might be linked to regional and global atrophy in Huntingtons Disease (HD). We ...
Variant Creutzfeldt-Jakob Disease and Bovine Spongiform Encephalopathy: Background, Pathophysiology and Etiology, Epidemiology
... also known as mad cow disease, and variant Creutzfeldt-Jakob disease (CJD) are related disorders. They belong to the family of ... diseases known as the transmissible spongiform encephalopathies (TSEs). ... Fluid-attenuated inversion recovery (FLAIR) image shows symmetrical pulvinar and dorsomedial thalamic nuclear hyperintensity. ... Centers for Disease Control and Prevention. Fact Sheet: New Variant Creutzfeldt-Jakob Disease. Centers for Disease Control and ...
Christopher Moran - Research output
- Research Profiles at Washington University School of Medicine
Division of Movement Disorders - Research output
- Research Profiles at Washington University School of Medicine
Thalamic and ventricular volumes predict motor response to deep brain stimulation for Parkinsons disease. Younce, J. R., ... Neuroinflammation and myelin status in Alzheimers disease, Parkinsons disease, and normal aging brains: A small sample study ... Younce, J. R., Davis, A. A. & Black, K. J., 2019, In: Journal of Parkinsons Disease. 9, 1, p. 63-71 9 p.. Research output: ... Silver, M. R., Racette, B. A., Dube, U., Faust, I. M. & Nielsen, S. S., 2020, In: Journal of Parkinsons Disease. 10, 2, p. 693 ...
Effect of Leukocyte Telomere Length on Total and Regional Brain Volumes in a Large Population-Based Cohort | Genetics and...
Combining shape and connectivity analysis: an MRI study of thalamic degeneration in Alzheimers disease. Neuroimage. 2010;49(1 ... Combining shape and connectivity analysis: an MRI study of thalamic degeneration in Alzheimers disease. Neuroimage. 2010;49(1 ... Mouiha A, Duchesne S; Alzheimers Disease Neuroimaging Initiative. Hippocampal atrophy rates in Alzheimers disease: automated ... Mouiha A, Duchesne S; Alzheimers Disease Neuroimaging Initiative. Hippocampal atrophy rates in Alzheimers disease: automated ...
Frontiers | Thalamic Circuit Mechanisms Link Sensory Processing in Sleep and Attention
As such, we propose that common thalamic circuit principles regulate sensory processing in a state-invariant manner and that in ... As such, we propose that common thalamic circuit principles regulate sensory processing in a state-invariant manner and that in ... Using multi-electrode recordings in mice, we find that rate and rhythmicity of thalamic reticular nucleus (TRN) neurons are ... Using multi-electrode recordings in mice, we find that rate and rhythmicity of thalamic reticular nucleus (TRN) neurons are ...
PATH51 Investigating adenosine A2A receptor availability in Parkinson's disease patients with and without levodopa induced...
Thalamic BP was similar between all PD subjects. The striatal BPs of controls lay within the BP range of the PD subjects ... Striatal and thalamic binding potentials (BP) reflecting the ratio of specific:nonspecific uptake were compared between groups. ... Objective To investigate adenosine 2A (A2A) receptor availability in Parkinsons disease (PD) patients with and without ... PATH51 Investigating adenosine A2A receptor availability in Parkinsons disease patients with and without levodopa induced ...
Diagnosis of Celiac Disease and Environmental Enteropathy on Biopsy
Images Using Color Balancing on Convolutional Neural...
Celiac Disease (CD) and Environmental Enteropathy (EE) are common causes of malnutrition and adversely impact normal childhood ... A Contrast Synthesized Thalamic Nuclei Segmentation Scheme using Convolutional Neural Networks Thalamic nuclei have been ... CeliacNet: Celiac Disease Severity Diagnosis on Duodenal Histopathological Images Using Deep Residual Networks Celiac Disease ( ... Classification of Alzheimers Disease using fMRI Data and Deep Learning Convolutional Neural Networks Over the past decade, ...
Parkinson'sNucleiAtrophyCortico-basal ganglia-thalamicNucleusMultiple sclerosisNeuronsNeuronalInfarctionDysfunctionLesionsStimulationNeurological diseasesNeuropathic painEssential tremorDopaminergicAlzheimer'sNeurodegenerativeVolumesCerebellarBasal gangliaStriatalSymptomsPatientsCognitiveClinicalParkinson DiseaseDisordersStructuralCerebralOnsetAutoimmuneHuntington's DiseaseChronicParkinsonismBrainCeliac DiseaseTherapeutic
Parkinson's53
- DESCRIPTION (provided by applicant): Parkinson's disease is a chronic, disabling neurologic disorder causing resting tremor, muscular rigidity, bradykinesia and impairment of gait. (neurodegenerationresearch.eu)
- It is estimated that 5 million people worldwide have Parkinson's disease, and this number is projected to reach 8.7 million by 2030. (neurodegenerationresearch.eu)
- A pathologic hallmark of Parkinson's disease is degeneration of the dopaminergic neurons in the substantia nigra pars compacta projecting to the striatum. (neurodegenerationresearch.eu)
- The efficacy of new treatments such as deep brain stimulation (DBS) to the subthalamic nucleus (STN) or the internal segment of the globus pallidus (GPi) highlights the fact that Parkinson's disease is a network disorder, involving alteration of the dynamics within and between the nuclei of the basal ganglia, the thalamus and the cortex. (neurodegenerationresearch.eu)
- Modulation of beta oscillations occurs with normal movement, and exaggeration of beta oscillations in the basal ganglia and cortex are characteristic of Parkinson's disease. (neurodegenerationresearch.eu)
- This will help us understand not only points of interception of the pathologic beta rhythm in Parkinson's disease, which may help alleviate symptoms of motor disability, but also identify how to minimize side effects of potential therapeutic interventions such as DBS that are thought to interfere with the transmission of beta oscillations in Parkinson's disease. (neurodegenerationresearch.eu)
- Drs. Han and McCarthy have successfully worked together integrating mathematical modeling and experimentation to put forth a new hypothesis for the origin of the pathologic beta rhythm in Parkinson's disease. (neurodegenerationresearch.eu)
- Broader Impact: Dysfunction of cortico-basal ganglia-thalamic loop has been implicated in other disorders of importance on both the individual and societal levels including Parkinson's disease, schizophrenia, Huntington's disease, depression, obsessive-compulsive disorder, addiction, Tourette's syndrome, dystonias and dyskinesias. (neurodegenerationresearch.eu)
- Defining the micro-circuitry of the cortio-basal ganglia-thalamic loop is not only a critical step towards understanding alternative therapeutic interventions in Parkinson's disease, it has the potential to advance new therapeutic options for individuals with other disorders with basal ganglia involvement. (neurodegenerationresearch.eu)
- These are the four motor symptoms found in Parkinson's disease (PD) - after which it is named - dementia with Lewy bodies (DLB), Parkinson's disease dementia (PDD), and many other conditions. (wikipedia.org)
- Parkinsonism is a clinical syndrome characterized by the four motor symptoms found in Parkinson's disease: tremor, bradykinesia (slowed movements), rigidity, and postural instability. (wikipedia.org)
- Drug-induced parkinsonism tends to remain at its presenting level and does not worsen like Parkinson's disease. (wikipedia.org)
- After 10 years of experience with DBS in Parkinson's disease, a comparison of results between the teams of Lille (A) and Grenoble (B) was carried out, for as long as they used intraoperative ventriculography. (bmj.com)
- Deep brain stimulation (DBS) has become a widely accepted method for the treatment of Parkinson's disease symptoms and concerns three major targets-namely, the nucleus ventralis intermedius (VIM), the internal part of the globus pallidus (GPi), and the subthalamic nucleus (STN). (bmj.com)
- Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by distal (i.e., tremor, bradykinesia, and rigidity) and axial motor symptoms (i.e., gait and postural disturbances). (springer.com)
- Prevalence of Parkinson's disease across North America. (springer.com)
- S.L. Kowal, T.M. Dall, R. Chakrabarti, M.V. Storm, A. Jain, The current and projected economic burden of Parkinson's disease in the United States. (springer.com)
- Freezing of gait in patients with advanced Parkinson's disease. (springer.com)
- B.R. Bloem, J.M. Hausdorff, J.E. Visser, N. Giladi, Falls and freezing of gait in Parkinson's disease: a review of two interconnected, episodic phenomena. (springer.com)
- J.J. Crouse, J.R. Phillips, M. Jahanshahi, A.A. Moustafa, Postural instability and falls in Parkinson's disease. (springer.com)
- Investigating the anatomy and microstructure of the dentato-rubro-thalamic and subthalamo-ponto-cerebellar tracts in Parkinson's disease. (mpg.de)
- Cardinal motor features of Parkinson's disease (PD) include bradykinesia, rest tremor, and rigidity, which appear in the early stages of the disease and largely depend on dopaminergic nigrostriatal denervation. (hindawi.com)
- Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease (AD), with an overall prevalence of 300 per 100,000 [ 1 ] that rises from 41 in the 40-49 years' age range to 1903 in people older than age of 80 years [ 2 ]. (hindawi.com)
- The glossary of the main motor and nonmotor symptoms and signs in Parkinson's disease. (hindawi.com)
- Deep brain stimulation may stop uncontrollable shaking in patients with Parkinson's disease and essential tremor by imposing its own rhythm on the brain, according to two recent studies. (sciencedaily.com)
- Deep-brain stimulation (DBS) may stop uncontrollable shaking in patients with Parkinson's disease and essential tremor by imposing its own rhythm on the brain, according to two studies published recently by University of Alabama at Birmingham researchers in the journal Movement Disorders . (sciencedaily.com)
- a related article on Parkinson's disease was released May 30. (sciencedaily.com)
- This suggests that DBS may synchronize the firing of nerve cells and break the abnormal rhythms associated with involuntary movements in Parkinson's disease and essential tremor. (sciencedaily.com)
- Prosaposin (PSAP) modulates glycosphingolipid metabolism and variants have been linked to Parkinson's disease (PD). (nature.com)
- Parkinson's disease (PD) is a progressive neurodegenerative disorder featured by dopaminergic neuronal loss in the substantia nigra pars compacta (SNc) and accumulation of intracellular α-synuclein (α-syn)-containing Lewy bodies 1 . (nature.com)
- Objective To investigate adenosine 2A (A2A) receptor availability in Parkinson's disease (PD) patients with and without levodopa induced dyskinesias (LID). (bmj.com)
- Hypomania and saccadic changes in Parkinson's disease: influence of D2 and D3 dopaminergic signalling. (mpg.de)
- Cortico-basal white matter alterations occurring in Parkinson's disease. (mpg.de)
- Dopamine substitution alters effective connectivity of cortical prefrontal, premotor, and motor regions during complex bimanual finger movements in Parkinson's disease. (mpg.de)
- Axonal degeneration in Parkinson's disease - Basal ganglia circuitry and D2 receptor availability. (mpg.de)
- Altered thalamic glucose metabolism in cerebellar projections in Parkinson's disease. (mpg.de)
- Classification of symptom-side predominance in idiopathic Parkinson's disease. (mpg.de)
- Background: Parkinson's disease (PD) is characterized by motor deficits and brain alterations having a detrimental impact on balance, gait, and cognition. (lu.se)
- DBS is currently approved in the U.S. or Europe for the treatment of essential tremor, Parkinson's disease, dystonia (a motor disorder that causes extreme twisting and repetitive motions), epilepsy, and obsessive-compulsive disorder (OCD). (the-scientist.com)
- In Parkinson's disease and dystonia, neurons in the motor circuits misfire, causing aberrant movements of the limbs and torso. (the-scientist.com)
- More than 100,000 patients worldwide have received DBS, mostly to treat Parkinson's disease, according to Medtronic, a prominent supplier of DBS devices. (the-scientist.com)
- We leveraged this experience and combined it with conceptual advances and surgical developments in the field of Parkinson's disease, and soon applied DBS to treat that disease and other movement disorders. (the-scientist.com)
- Deep brain stimulation in early stage Parkinson's disease: Is it disease modifying? (mdsabstracts.org)
- A brainwave abnormality could be a common link between Parkinson's disease, neuropathic pain, tinnitus, and depression-a link that authors of a new study suggest could lead to treatment for all four conditions. (hearingreview.com)
- About half were healthy control subjects, while the remainder were patients with tinnitus, chronic pain, Parkinson's disease, or major depression. (hearingreview.com)
- Moreover, the duration of Parkinson's disease was an independent predictor of visual hallucinations in the multivariate analysis. (parkinsonsdaily.com)
- For almost 25 years, the Parkinson Foundation has been funding basic scientific research into the cause of Parkinson's disease. (parkinsonfonds.nl)
- And it is desperately needed - especially now that Parkinson's disease is the fastest growing brain disease and is being diagnosed more often in younger people. (parkinsonfonds.nl)
- Title study: Is isolated REM-sleep-without-Atonia a very early (earlier than REM Sleep Behavior Disorder prodromal stage of Parkinson's disease? (parkinsonfonds.nl)
- Although open-label observations report a positive effect of cannabinoids on non-motor symptoms (NMS) in Parkinson's disease (PD) patients, these effects remain to be investigated in a controlled trial for a broader use in NMS in PD patients. (springer.com)
- The primary efficacy criterion will be the change in Movement Disorders Society-Unified Parkinson's Disease-Rating Scale Part I score between baseline (i.e. randomization) and week 4. (springer.com)
- Although Parkinson's disease (PD) is generally considered a paradigmatic movement disorder, it has long been recognized that the neuropathology underlying PD involves many brain areas that are not directly involved in motor control (Braak et al. (springer.com)
- Finally, welders' motor function was examined using the Unified Parkinson's Disease Rating Scale (UPDRS). (cdc.gov)
Nuclei15
- They propose to extend this model to include mathematical models of each of the nuclei of the cortico-basal ganglia-thalamic loop. (neurodegenerationresearch.eu)
- The results of the combined mathematical and experimental work will promote insight into the networks both within and between the nuclei of the cortico-basal ganglia-thalamic loop that support the propagation of beta rhythms in the normal dopamine state and the alterations that occur to these networks in the parkinsonian state. (neurodegenerationresearch.eu)
- This study sheds light on the relationship between the thalamic nuclei volume and their lateralization with cognitive and motor scores in PD. (ismrm.org)
- Cognitive deficits in semantic fluency and symbols and digits tests in PD are related to ventral, central and medial thalamic nuclei rather than to specific nuclei differences, except for the right-AV. Motor deterioration seems to be reflected in specific lateralization of the medial and pulvinar areas. (ismrm.org)
- Thalamus Optimized Multi Atlas Segmentation (THOMAS): fast, fully automated segmentation of thalamic nuclei from structural MRI. (umassmed.edu)
- In vivo high-resolution structural MRI-based atlas of human thalamic nuclei. (umassmed.edu)
- White-matter-nulled MPRAGE at 7T reveals thalamic lesions and atrophy of specific thalamic nuclei in multiple sclerosis. (umassmed.edu)
- Thalamic nuclei have been implicated in several neurological diseases. (deepai.org)
- These areas are the cerebral cortex, the hippocampus, the amygdala, several basal and thalamic nuclei, and the cerebellar cortical Purkinje cells. (vin.com)
- Specific thalamic nuclei are implicated in healthy aging and age-related neurodegenerative diseases. (umassmed.edu)
- However, few methods are available for robust automated segmentation of thalamic nuclei. (umassmed.edu)
- The threefold aims of this study were to validate the use of a modified thalamic nuclei segmentation method on standard T1 MRI data, to apply this method to quantify age-related volume declines, and to test functional meaningfulness by predicting performance on motor testing. (umassmed.edu)
- A modified version of THalamus Optimized Multi-Atlas Segmentation (THOMAS) generated 22 unilateral thalamic nuclei. (umassmed.edu)
- Significant sICV-adjusted correlations between age and thalamic nuclear volumes were detected in 20 of the 22 unilateral nuclei and whole thalamus. (umassmed.edu)
- Pfefferbaum A, Sullivan EV, Zahr NM, Pohl KM, Saranathan M. Multi-atlas thalamic nuclei segmentation on standard T1-weighed MRI with application to normal aging. (umassmed.edu)
Atrophy11
- Hippocampal CA1 apical neuropil atrophy and memory performance in Alzheimer's disease. (umassmed.edu)
- These results provide compelling evidence for a direct relationship between white matter lesions and thalamic atrophy in CIS patients. (nih.gov)
- Microstructure damage in white matter might be linked to regional and global atrophy in Huntington's Disease (HD). (frontiersin.org)
- Brain atrophy progression measured from registered serial MRI: validation and application to Alzheimer's disease. (jamanetwork.com)
- Rate of medial temporal lobe atrophy in typical aging and Alzheimer's disease. (jamanetwork.com)
- Hippocampal atrophy rates in Alzheimer disease: added value over whole brain volume measures. (jamanetwork.com)
- Serial magnetic resonance imaging of cerebral atrophy in preclinical Alzheimer's disease. (jamanetwork.com)
- Recent studies found atrophy of the thalamus in all different MS disease types and detected thalamic volume loss in pediatric MS patients. (dieurope.com)
- Thalamic atrophy may become a hallmark of how we look at the disease and how we develop drugs to treat it," Dr Zivadinov said. (dieurope.com)
- For this study, his colleagues and he investigated the association between the development of thalamic atrophy and conversion to clinically definite MS. "One of the most important reasons for the study was to understand which regions of the brain are most predictive of a second clinical attack," he said. (dieurope.com)
- Thalamic atrophy is an ideal MRI biomarker because it's detectable at very early stage," Dr. Zivadinov said. (dieurope.com)
Cortico-basal ganglia-thalamic7
- The search for alternative therapies has begun to focus on the interactions of networks within the cortico-basal ganglia-thalamic loop. (neurodegenerationresearch.eu)
- Intellectual Merit: This proposed research is designed to characterize the network dynamics that allow the propagation of beta oscillations through the cortico-basal ganglia-thalamic loop in both the normal and parkinsonian states. (neurodegenerationresearch.eu)
- Thus, we seek to understand the networks supporting transmission of beta oscillations in the normal cortico-basal ganglia-thalamic loop and then determine how the network interactions are altered to allow the exaggeration and abnormal propagation of beta oscillations in the parkinsonian state. (neurodegenerationresearch.eu)
- The research proposed here will make use of their model of striatal beta rhythm generation to understand the propagation of beta oscillations throughout the cortico-basal ganglia-thalamic loop in both the normal and low dopamine states. (neurodegenerationresearch.eu)
- Circuit-level analyses of cortico-basal ganglia-thalamic networks. (lu.se)
- The cortico-basal ganglia-thalamic (CBT) circuit is thought to be involved in control of voluntary and goal-directed movements and action selection. (lu.se)
- Dive into the research topics of 'Circuit-level analyses of cortico-basal ganglia-thalamic networks. (lu.se)
Nucleus7
- Although DBS at the subthalamic nucleus (STN) and the internal globus pallidus (GPi) are well established for the treatment of the distal symptoms in PD, long-term studies of axial symptoms show a decline in efficacy with progression of the disease. (springer.com)
- Sensitivity of ventrolateral posterior thalamic nucleus to back pain in alcoholism and CD4 nadir in HIV. (umassmed.edu)
- Using multi-electrode recordings in mice, we find that rate and rhythmicity of thalamic reticular nucleus (TRN) neurons are predictive of their functional organization in sleep and suggestive of their participation in sensory processing across states. (frontiersin.org)
- Spindles are generated by interactions between thalamic reticular nucleus (TRN) neurons and thalamo-cortical relay neurons. (frontiersin.org)
- Probabilistic tractography in the ventrolateral thalamic nucleus: cerebellar and pallidal connections. (mpg.de)
- However, the optimal target for SRS treatment within the thalamic ventral intermediate nucleus (VIM) is not clearly defined. (thejns.org)
- Within the anatomically distinct thalamo-cortical projection systems, magnetic resonance imaging derived cortical thickness was correlated significantly with both a measure of myelination in the connected tract and a measure of connected thalamic nucleus cell density. (ox.ac.uk)
Multiple sclerosis5
- My current research interests are focused on ultra high-resolution imaging and segmentation of deep brain structures like thalamus and hippocampus and the specificity of their involvement in pathology such as alcoholism, multiple sclerosis, Alzheimer's disease, and essential tremor. (umassmed.edu)
- Previous studies suggest that thalamic degeneration is prominent in multiple sclerosis (MS) and even in pre-MS patients presenting with a clinically isolated syndrome (CIS). (nih.gov)
- It's never too early to stay ahead of progression in multiple sclerosis, since the early identification of physical and cognitive changes-even subtle ones—can indicate MS disease progression and therefore allow for timely intervention. (neurologylive.com)
- Multiple sclerosis is a common, chronic demyelinating neurological disease primarily affecting young adults, with a prevalence of ~0.1% in the Caucasian population (Miller and Leary, 2007). (medscape.com)
- Diagnostic criteria and classification of multiple sclerosis subtypes have evolved in recent decades, and, although successive versions have differed in emphasis, all have required dissemination of disease in space (requiring involvement of multiple areas of the CNS) and in time (requiring ongoing disease activity over time). (medscape.com)
Neurons4
- When the cortex sends top-down signals to the thalamus, it can enhance or suppress the activity of thalamic neurons, depending on the task at hand. (springernature.com)
- For example, when we focus our attention on a particular sensory input, such as a sound or visual cue, the cortex can increase the activity of thalamic neurons that relay information about that stimulus. (springernature.com)
- Conversely, when we ignore a particular stimulus, the cortex can suppress the activity of thalamic neurons that relay information about that stimulus. (springernature.com)
- A key property of alpha waves is to induce thalamic lateral inhibition, which means that specific neurons can quiet the activity of adjacent neurons. (hearingreview.com)
Neuronal1
- Our SPECT study revealed that neuropathic pain altered thalamic neuronal activity. (openneuroimagingjournal.com)
Infarction4
- The usual differential diagnosis for posterior cerebral artery (PCA) stroke includes other vascular diseases such as intracerebral hemorrhage, cerebral venous infarction, subarachnoid hemorrhage, and subdural hemorrhage. (medscape.com)
- Isolated lateral thalamic infarction: the role of posterior cerebral artery disease. (medscape.com)
- A case report: Numb Chin Syndrome due to thalamic infarction: a rare case. (iasp-pain.org)
- In this article we present the very rare case of a clinical NCS caused by thalamic lacunar infarction. (iasp-pain.org)
Dysfunction3
- Here, we provide an alternative explanation for this correlation: common thalamic circuits regulate sensory processing across sleep and attention, and their disruption may lead to correlated dysfunction. (frontiersin.org)
- Celiac Disease and diabetes mellitus Diabetes mellitus Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia and dysfunction of the regulation of glucose metabolism by insulin. (lecturio.com)
- Title : Thalamocortical Dysfunction and Thalamic Injury after Asphyxial Cardiac Arrest in Developing Rats Personal Author(s) : Shoykhet, Michael;Simons, Daniel J.;Alexander, Henry;Hosler, Christina;Kochanek, Patrick M.;Clark, Robert S. B. (cdc.gov)
Lesions1
- DTI metrics in the lesions and normal-appearing white matter (NAWM) regions were compared between CIS and controls, and correlated with thalamic volume changes estimated by voxel-based morphometry. (nih.gov)
Stimulation1
- Interestingly, this rapid response on the brain surface was present in both studies, regardless of the stimulation target or the disease state of the patient. (sciencedaily.com)
Neurological diseases2
- Magnetic resonance imaging (MRI) is a non-invasive technique that provides insight about diagnosis and treatment for neurological diseases. (frontiersin.org)
- The strength of our paper is that we have a large enough data sample to show that TCD could be an explanation for several neurological diseases. (hearingreview.com)
Neuropathic pain2
- We employed single photon emission computed tomography (SPECT) to evaluate the thalamic perfusion in patients with spontaneous neuropathic pain. (openneuroimagingjournal.com)
- In one study, we found elevation of CTUI in patients with symptoms of neuropathic pain for less than 12 month, whereas no change was observed in the case of a longer lasting disease. (openneuroimagingjournal.com)
Essential tremor1
- Stereotactic radiosurgery (SRS) treats severe, medically refractory essential tremor and tremor-dominant Parkinson disease. (thejns.org)
Dopaminergic1
- Pharmacological therapy is based on levodopa and dopamine agonists and is very successful in the early stages of the disease, when dopaminergic symptoms and signs are predominant and long term motor complications still have not developed, but other treatment strategies are almost invariably necessary as time passes [ 3 ]. (hindawi.com)
Alzheimer's9
- Alzheimer's disease (AD) is the leading cause of dementia in aged population. (nature.com)
- Alzheimer's disease (AD) is an insidious, progressive, and devastating neurodegenerative disease, which is recognized as the leading cause of dementia in aged population. (nature.com)
- Imaging of onset and progression of Alzheimer's disease with voxel-compression mapping of serial magnetic resonance images. (jamanetwork.com)
- Alzheimer's Disease Neuroimaging Initiative. (jamanetwork.com)
- Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease. (jamanetwork.com)
- Telomere shortening in T cells correlates with Alzheimer's disease status. (jamanetwork.com)
- Thomas P, O'Callaghan NJ, Fenech M. Telomere length in white blood cells, buccal cells and brain tissue and its variation with ageing and Alzheimer's disease. (jamanetwork.com)
- The therapy is currently in clinical trials for depression, Alzheimer's disease, addiction, and more. (the-scientist.com)
- Impairment of the activity in circuits that control memory and cognitive function is characteristic of Alzheimer's disease. (the-scientist.com)
Neurodegenerative1
- This set of symptoms occurs in a wide range of conditions and may have many causes, including neurodegenerative conditions, drugs, toxins, metabolic diseases, and neurological conditions other than PD. (wikipedia.org)
Volumes1
- To examine the effects of age/sex on thalamic nuclear volumes, T1 MRI available from a second data set of 121 men and 117 women, ages 20-86 years, were segmented using THOMAS. (umassmed.edu)
Cerebellar1
- In the HiBalance group we found community structure changes and stronger thalamic-cerebellar connectivity in structural covariance networks. (lu.se)
Basal ganglia1
- Thalamic interactions of cerebellum and basal ganglia. (mpg.de)
Striatal2
Symptoms4
- Nonmotor symptoms and signs are integral to PD at onset and throughout the disease course, but to date their treatment is largely unsatisfactory [ 9 ]. (hindawi.com)
- One of the lesser-known symptoms of Parkinsons Disease is Parkinsons psychosis. (parkinsonsdaily.com)
- The continuum hypothesis states that medication-induced psychiatric symptoms in Parkinsons disease starts with sleep disturbances accompanied by vivid dreams, and then develops into hallucinations and delusions, and ends in delirium. (parkinsonsdaily.com)
- Approximately 15% of patients follow a primary progressive or progressive relapsing course from disease onset, usually characterized by symptoms of progressive myelopathy (gait instability, spasticity, bladder symptoms) and cognitive impairment. (medscape.com)
Patients5
- Long term levodopa-induced motor complications include motor fluctuations and dyskinesia and affect almost all PD patients at some point during the disease course, with relevant implications in global health status [ 11 ]. (hindawi.com)
- Disease progression was observed in 9 patients (median progression-free survival 7.3 years). (nih.gov)
- Seven patients were without evidence of disease, 6 had stable disease, 7 stable following progression and 1 had progressive disease managed expectantly. (nih.gov)
- The disease is usually asymptomatic, although some patients Patients Individuals participating in the health care system for the purpose of receiving therapeutic, diagnostic, or preventive procedures. (lecturio.com)
- For both, PPMS patients according to revised McDonald 2010 criteria and RMS patients meeting criteria for PMS disease course as per Lublin et al. (who.int)
Cognitive1
- Hanlon RE, Dobkin BH, Hadler B, Ramirez S, Cheska Y. Neurorehabilitation following right thalamic infarct: effects of cognitive retraining on functional performance. (medscape.com)
Clinical1
- Both conditions require a tissue biopsy for diagnosis, and a major challenge of interpreting clinical biopsy images to differentiate between these gastrointestinal diseases is striking histopathologic overlap between them. (deepai.org)
Parkinson Disease1
- J.M. Fearnley, A.J. Lees, Ageing and Parkinson' disease: substantia nigra regional selectivity. (springer.com)
Disorders5
- Bovine spongiform encephalopathy (BSE), also known as mad cow disease, and variant Creutzfeldt-Jakob disease (CJD) are related disorders. (medscape.com)
- As such, we propose that common thalamic circuit principles regulate sensory processing in a state-invariant manner and that in certain disorders, targeting these circuits may be a more viable therapeutic strategy than considering individual states in isolation. (frontiersin.org)
- These findings support a model in which common thalamic circuits regulate sensory processing across sleep and attention, and suggest that targeting these circuits or their computational principles may be an effective therapeutic strategy in neurodevelopmental disorders. (frontiersin.org)
- But no one combined the different disorders to say, 'What's the difference between these diseases in terms of brainwaves, and what do they have in common? (hearingreview.com)
- This group includes lysosomal storage disorders, various mitochondrial diseases, other neurometabolic disorders, and several other miscellaneous disorders. (medscape.com)
Structural1
- OBJECTIVE: To characterize abnormal cortico-thalamic structural/streamline connectivity (SC) patterns in the disease, as well as their potential co-occurrence with abnormal subcortico-thalamo-cortical projections using diffusion tractography. (bvsalud.org)
Cerebral1
- 5 Any diseases which affect the cerebral blood vessels will cause disturbances of the cerebral blood flow (CBF) which in turn can lead to tissue damage. (vin.com)
Onset3
- Disease duration is the time between onset of CJD and the appearance of akinetic mutism or death. (cdc.gov)
- For some time we've been trying to understand MRI biomarkers that predict MS development from the first onset of the disease," said Dr Robert Zivadinov, of the Buffalo Neuroimaging Analysis Center. (dieurope.com)
- Have a length of disease duration since PMS disease symptom onset =10 years if baseline EDSS =5.0 and =15 years if baseline EDSS >5.0. (who.int)
Autoimmune2
- Celiac Disease (CD) is a chronic autoimmune disease that affects the sma. (deepai.org)
- Clinician-Patient Relationship with autoimmune diseases such as celiac disease Celiac disease Celiac disease (also known as celiac sprue or gluten enteropathy) is an autoimmune reaction to gliadin, which is a component of gluten. (lecturio.com)
Huntington's Disease2
- A critical review of white matter changes in Huntington's disease. (mpg.de)
- Huntington's Disease (HD) is an autosomal dominant genetic disease that results in progressive neurodegeneration. (frontiersin.org)
Chronic2
- Other TSEs include scrapie (a disease of sheep), feline spongiform encephalopathy, transmissible mink encephalopathy, and chronic wasting disease of deer and elk. (medscape.com)
- CTUIs were increased in early stage of the disease but decreased as the disease progressed to the chronic stage. (openneuroimagingjournal.com)
Parkinsonism1
- A mutation of the SLC30A10 gene, a manganese efflux transporter necessary for decreasing intracellular Mn, has been linked with the development of this parkinsonism-like disease. (wikipedia.org)
Brain4
- In MS, it is common to acquire brain and spinal cord MR imaging sequences separately to assess the extent of the disease. (ajnr.org)
- Depending on the disease, different areas of the brain become involved. (hearingreview.com)
- From here, we hope to stimulate specific brain areas involved in these diseases at alpha frequencies to normalize the brainwaves again. (hearingreview.com)
- In conclusion, our study shows that effects from changes in Mn exposure are reflected in thalamic GABA levels and brain Mn levels, as measured by R1, in most brain regions. (cdc.gov)
Celiac Disease3
- Celiac Disease (CD) and Environmental Enteropathy (EE) are common causes of malnutrition and adversely impact normal childhood development. (deepai.org)
- Celiac Disease (CD) and Environmental Enteropathy (EE) are common causes. (deepai.org)
- Celiac disease is closely associated with HLA-DQ2 and HLA-DQ8. (lecturio.com)
Therapeutic1
- And, for the first time, this 4th edition describes the current efforts to translate the discoveries in epilepsy disease mechanisms into new therapeutic strategies. (ebooksmedicine.net)
