Tinea Pedis
Tinea
Trichophyton
Onychomycosis
Tinea Versicolor
Tinea Capitis
Candidiasis, Cutaneous
Arthrodermataceae
Tinea Favosa
Antifungal Agents
Microsporum
Management and morbidity of cellulitis of the leg. (1/41)
Ascending cellulitis of the leg is a common emergency. An audit was conducted in two district general hospitals to determine how it is managed and the long-term morbidity, and to formulate a treatment strategy. Case notes were reviewed for 92 patients admitted to hospital under adult specialties. Mean duration of inpatient therapy was 10 days. A likely portal of entry was identified in 51/92 cases, of which the commonest were minor injuries and tinea pedis. Pathogens were rarely identified, group G streptococci being the single most frequent organism. Benzylpenicillin was administered in only 43 cases. Long-term morbidity, identified in 8 of 70 patients with over six months' follow-up, included persistent oedema (6) and leg ulceration (2); an additional 19 patients had either suffered previous episodes or experienced a further episode subsequently. Ascending cellulitis of the leg has substantial short-term and long-term morbidity. Important but often neglected therapeutic suggestions are the inclusion of benzylpenicillin in all cases without a contraindication, assessment and treatment of tinea pedis, use of support hosiery, and serological testing for streptococci to confirm the diagnosis in retrospect. The high frequency of recurrent episodes suggests that longer courses of penicillin, or penicillin prophylaxis, might be useful. (+info)Prevalence and risk factors of tinea unguium and tinea pedis in the general population in Spain. (2/41)
This study prospectively evaluated the prevalence and risk factors of tinea unguium and tinea pedis in the general adult population in Madrid, Spain. One thousand subjects were clinically examined, and samples of nails and scales from the interdigital spaces of the feet were taken from those patients presenting with signs or symptoms of onychomycosis and/or tinea pedis, respectively. In addition, a sample from the fourth interdigital space of both feet was collected from all individuals with a piece of sterilized wool carpet. Tinea unguium was defined as a positive direct examination with potassium hydroxide and culture of the etiological agent from subjects with clinically abnormal nails. Patients with positive dermatophyte cultures of foot specimens were considered to have tinea pedis. The prevalence of tinea unguium was 2.8% (4.0% for men and 1.7% for women), and the prevalence of tinea pedis was 2.9% (4.2% for men and 1.7% for women). The etiological agents of tinea unguium were identified as Trichopyton rubrum (82.1%), followed by Trichopyton mentagrophytes var. interdigitale (14.3%) and Trichopyton tonsurans (3.5%). Trichophyton rubrum (44.8%) and Trichophyton mentagrophytes (44.8%), followed by Epidermophyton floccosum (7%) and T. tonsurans (3.4%), were the organisms isolated from patients with tinea pedis. The percentage of subjects who suffered simultaneously from both diseases was 1.1% (1.7% for men and 0.6% for women). In a multivariate logistic regression analysis, age (relative risk [RR], 1.03) and gender (RR, 2.50) were independent risk factors for tinea unguium, while only gender (RR, 2.65) was predictive for the occurrence of tinea pedis. In both analyses, the presence of one of the two conditions was associated with a higher risk for the appearance of the other disease (RR, >25). (+info)Lactoferrin given in food facilitates dermatophytosis cure in guinea pig models. (3/41)
Dermatophytosis is the most common skin infection caused by dermatophytic fungi, such as Trichophyton spp. We studied the in vitro and in vivo antifungal effects of lactoferrin against Trichophyton. Human and bovine lactoferrin, and a bovine lactoferrin-derived peptide, lactoferricin B, showed in vitro antifungal activity that was dependent on the test strain and medium used. In guinea pigs infected on the back with Trichophyton mentagrophytes (i.e. those with tinea corporis), consecutive daily po administration of bovine lactoferrin did not prevent development of symptoms during the early phase of infection, but facilitated clinical improvement of skin lesions after the peak of the symptoms. The fungal burden in lesions was less in guinea pigs that had been given lactoferrin than in untreated controls 21 days after infection. In guinea pigs infected on the foot with T. mentagrophytes (i.e. those with tinea pedis), the fungal burden of the skin on the heel portion of the infected foot 35 days after infection was lower in animals fed lactoferrin than in controls. These results suggest the potential usefulness of lactoferrin as a food component for promoting dermatophytosis cure. (+info)In vitro antifungal activity of KP-103, a novel triazole derivative, and its therapeutic efficacy against experimental plantar tinea pedis and cutaneous candidiasis in guinea pigs. (4/41)
The in vitro activity of KP-103, a novel triazole derivative, against pathogenic fungi that cause dermatomycoses and its therapeutic efficacy against plantar tinea pedis and cutaneous candidiasis in guinea pigs were investigated. MICs were determined by a broth microdilution method with morpholinepropanesulfonic acid-buffered RPMI 1640 medium for Candida species and with Sabouraud dextrose broth for dermatophytes and by an agar dilution method with medium C for Malassezia furfur. KP-103 was the most active of all the drugs tested against Candida albicans (geometric mean [GM] MIC, 0.002 microg/ml), other Candida species including Candida parapsilosis and Candida glabrata (GM MICs, 0.0039 to 0.0442 microg/ml), and M. furfur (GM MIC, 0.025 microg/ml). KP-103 (1% solution) was highly effective as a treatment for guinea pigs with cutaneous candidiasis and achieved mycological eradication in 8 of the 10 infected animals, whereas none of the imidazoles tested (1% solutions) was effective in even reducing the levels of the infecting fungi. KP-103 was as active as clotrimazole and neticonazole but was less active than lanoconazole and butenafine against Trichophyton rubrum (MIC at which 80% of isolates are inhibited [MIC(80)], 0.125 microg/ml) and Trichophyton mentagrophytes (MIC(80), 0.25 microg/ml). However, KP-103 (1% solution) exerted therapeutic efficacy superior to that of neticonazole and comparable to those of lanoconazole and butenafine, yielding negative cultures for all samples from guinea pigs with plantar tinea pedis tested. This suggests that KP-103 has better pharmacokinetic properties in skin tissue than the reference drugs. Because the in vitro activity of KP-103, unlike those of the reference drugs, against T. mentagrophytes was not affected by hair as a keratinic substance, its excellent therapeutic efficacy seems to be attributable to good retention of its antifungal activity in skin tissue, in addition to its potency. (+info)A prospective epidemiological study on tinea pedis and onychomycosis in Hong Kong. (5/41)
OBJECTIVE: To study the epidemiology of foot diseases, including tinea pedis and onychomycosis in clinic attendees in Hong Kong. METHODS: Two groups were included: the institutional group consisted of clinical evaluation and mycological investigations by dermatologists; and the private group consisted of clinical evaluation only by the private physicians. Patients who had a regular visit to the clinics were randomly invited to have a clinical examination of their feet. RESULTS: A total of 1014 patients were studied. The prevalence rate of foot disease, fungal infections, tinea pedis and toe nail onychomycosis were respectively 50.7%, 26.9%, 20.4% and 16.6%. More male and elderly patients were affected except that the sex prevalence in toe nail onychomycosis was not shown to be significant. Vascular disease, diabetes mellitus and obesity were the three most prevalent predisposing factors in foot disease, fungal disease and fungal nail disease. Dermatophytes, in particular Trichophyton rubrum, were shown to be the most common pathogen in both skin and nail infections. CONCLUSIONS: Foot diseases, especially tinea pedis and toe nail onychomycosis, are common in patients attending local clinics in Hong Kong. Both physicians and patients should be more aware of foot problems and have more active approaches and management strategies. (+info)Therapeutic efficacy of topically applied KP-103 against experimental tinea unguium in guinea pigs in comparison with amorolfine and terbinafine. (6/41)
The therapeutic efficacy of KP-103, a novel topical triazole, in a guinea pig tinea unguium model was investigated. Experimental tinea unguium and tinea pedis were produced by inoculation of Trichophyton mentagrophytes SM-110 between the toes of the hind paw of guinea pigs. One percent solution (0.1 ml) of KP-103, amorolfine, or terbinafine was topically applied to the nails and whole sole of an infected foot once daily for 30 consecutive days, and terbinafine was also orally administered at a daily dose of 40 mg/kg of body weight for 30 consecutive days, starting on day 60 postinfection. The fungal burdens of nails and plantar skin were assessed using a new method, which makes it possible to recover infecting fungi by removing a carryover of the drug remaining in the treated tissues into the culture medium. Topically applied KP-103 inhibited the development of nail collapse, significantly reduced the fungal burden of the nails, and sterilized the infected plantar skin. On the other hand, topical amorolfine and topical or oral terbinafine were ineffective for tinea unguium, although these drugs eradicated or reduced the fungal burden of plantar skin. The in vitro activities of amorolfine and terbinafine against T. mentagrophytes SM-110 were 8- and 32-fold, respectively, decreased by the addition of 5% keratin to Sabouraud dextrose broth medium. In contrast, the activity of KP-103 was not affected by keratin because its keratin affinity is lower than those of the reference drugs, suggesting that KP-103 largely exists in the nails as an active form that was not bound to keratin and diffuses in the nail without being trapped by keratin. The effectiveness of KP-103 against tinea unguium is probably due to its favorable pharmacokinetic properties in the nails together with its potent antifungal activity. (+info)Skin disease among staff in a large Korean nursing home. (7/41)
Although previous studies have documented reasonably high rates of skin disease among nursing home staff, the prevalence among Korean workers is not well known. For this investigation we selected a large Korean nursing home and distributed a skin disease questionnaire to all staff. Questions included job title, job description, employment history, working hours, patient contact and the occurrence of skin disease over the past 12 months. Workers who reported a dermatological problem then underwent skin examinations conducted by specialist occupational physicians and a dermatologist. Contact dermatitis was the most common skin disease detected, with 4.8% of staff currently suffering from it and 6.0% reporting it in the previous 12-month period. Tinea pedis was another common condition, affecting 3.6% on our examination day. However, only two-thirds of them (2.4%) recounted a past history of tinea pedis. Scabies was diagnosed among 2.4% of staff and reported as a previous infection by 6.0%. Overall, the prevalence of dermatitis and scabies were quite low when compared to previous studies, while fungal infection rates were similar to other investigations. Further research into this growing occupational demographic is indicated. (+info)Relation between vesicular eruptions on the hands and tinea pedis, atopic dermatitis and nickel allergy. (8/41)
The aetiology of vesicular eruptions on the palms and on the sides of the fingers (pompholyx) is unclear. The present study was undertaken to establish whether tinea pedis, atopic dermatitis or nickel allergy is a risk factor for development of vesicular eruptions. Three-hundred-and-ninety-eight individuals (included from an ongoing population study on hand eczema in twins) were included. A history of previous hand eczema and atopic dermatitis was taken, and a clinical examination including a patch test with nickel was performed. A test sample for tinea pedis was taken from the fourth interdigital space on the right foot. The relative risk for vesicular eruptions present in individuals with tinea pedis was 3.58 (confidence limits 1.19-10.82, p < 0.05). For individuals with atopic dermatitis, relative risk was 1.44 (confidence limits 0.34-6.07, n.s.) and for those with nickel allergy it was 0.45 (confidence limits 0.06-3.36, n.s.). A relationship between tinea pedis and vesicular eruptions on the hands was statistically confirmed in the present study. In this part of the population study material, no association with atopic dermatitis or nickel allergy was observed. (+info)Tinea Pedis, also known as athlete's foot, is a fungal infection that affects the skin on the feet, particularly between the toes. The causative agents are dermatophytes, which thrive in warm and damp environments. Common symptoms include itching, burning, cracked, blistered, or scaly skin, and sometimes painful peeling or cracking of the skin. It is contagious and can spread to other parts of the body or to other people through direct contact or via contaminated surfaces. Proper hygiene, keeping the feet dry, and using antifungal medications are common methods of preventing and treating this condition.
Tinea is a common fungal infection of the skin, also known as ringworm. It's called ringworm because of its characteristic red, circular, and often scaly rash with raised edges that can resemble a worm's shape. However, it has nothing to do with any kind of actual worm.
The fungi responsible for tinea infections belong to the genus Trichophyton, Microsporum, or Epidermophyton. These fungi thrive in warm, damp environments and can be contracted from infected people, animals, or contaminated soil. Common types of tinea infections include athlete's foot (tinea pedis), jock itch (tinea cruris), and ringworm of the scalp (tinea capitis).
Treatment for tinea typically involves antifungal medications, either topical or oral, depending on the location and severity of the infection. Proper hygiene and avoiding sharing personal items can help prevent the spread of this contagious condition.
Trichophyton is a genus of fungi that are primarily responsible for causing various superficial and cutaneous infections in humans and animals. These infections, known as dermatophytoses or ringworm, typically involve the skin, hair, and nails. Some common examples of diseases caused by Trichophyton species include athlete's foot (T. rubrum), jock itch (T. mentagrophytes), and scalp ringworm (T. tonsurans).
The fungi in the Trichophyton genus are called keratinophilic, meaning they have a preference for keratin, a protein found in high concentrations in skin, hair, and nails. This characteristic allows them to thrive in these environments and cause infection. The specific species of Trichophyton involved in an infection will determine the clinical presentation and severity of the disease.
In summary, Trichophyton is a medical term referring to a group of fungi that can cause various skin, hair, and nail infections in humans and animals.
Onychomycosis is a medical term that refers to a fungal infection in the nails (both fingernails and toenails). This condition occurs when fungi, usually dermatophytes, invade the nail bed and cause damage to the nail plate. It can lead to symptoms such as discoloration, thickening, crumbling, and separation of the nail from the nail bed. Onychomycosis can be challenging to treat and may require long-term antifungal therapy, either topical or oral, or even removal of the infected nail in severe cases.
Tinea versicolor is a superficial fungal infection of the skin, caused by the pathogen Malassezia furfur (previously known as Pityrosporum ovale). It is characterized by the appearance of multiple round or oval patches that are hypopigmented (lighter than the surrounding skin) or hyperpigmented (darker than the surrounding skin), scaly, and can be pruritic (itchy). The lesions typically appear on the trunk and proximal extremities, often in a symmetrical pattern. Tinea versicolor is more common in warm, humid climates and in individuals with oily skin or weakened immune systems. It is usually diagnosed based on the clinical presentation and can be confirmed by microscopic examination of skin scrapings or fungal cultures. Treatment typically involves topical antifungal medications, such as clotrimazole, miconazole, or selenium sulfide, but oral medication may be necessary for severe or widespread infections.
'Epidermophyton' is a genus of fungi that can cause skin and nail infections in humans. These types of infections are known as dermatophytoses or ringworm infections. The most common species that infect humans is Epidermophyton floccosum, which tends to cause infections of the feet (athlete's foot), nails, and groin (jock itch).
Epidermophyton fungi thrive on keratin, a protein found in skin, hair, and nails. They invade the dead outer layers of the skin or nails, causing inflammation, itching, scaling, and other symptoms. The infections can be spread through direct contact with an infected person or contaminated objects like towels, shoes, or floors.
To diagnose an Epidermophyton infection, a healthcare professional may collect a sample from the affected area and examine it under a microscope for the presence of fungal elements. The diagnosis can also be confirmed through culture methods, where the sample is grown on specialized media to identify the specific fungal species.
Treatment for Epidermophyton infections typically involves topical or oral antifungal medications, depending on the severity and location of the infection. Preventive measures such as keeping the skin clean and dry, avoiding sharing personal items, and wearing breathable footwear can help reduce the risk of contracting and spreading these types of infections.
Tinea capitis is a dermatophyte infection, primarily affecting the scalp and hair. It is commonly known as "ringworm of the scalp." The term "ringworm" is a misnomer because it has nothing to do with worms; instead, it refers to the ring-like appearance of the rash caused by these fungi.
The infection is more prevalent in children than adults and can spread through direct contact with an infected person or animal (like pets), or via contaminated objects such as combs, brushes, hats, etc. The causative agents are typically mold-like fungi called dermatophytes, which belong to the genera Microsporum or Trichophyton.
Symptoms of tinea capitis include itchiness, scaling, hair loss (in patches), and the presence of black dots on the scalp where broken hairs remain. In some cases, inflammation and pustules may occur. Diagnosis is usually confirmed through microscopic examination of hair or scale samples, and sometimes by culture.
Treatment typically involves oral antifungal medications like griseofulvin, terbinafine, itraconazole, or fluconazole for several weeks to ensure complete eradication of the fungus. Topical antifungals are often used in conjunction with oral therapy. Good hygiene practices and avoiding sharing personal items can help prevent transmission.
Dermatomycoses are a group of fungal infections that affect the skin, hair, and nails. These infections are caused by various types of fungi, including dermatophytes, yeasts, and molds. Dermatophyte infections, also known as tinea, are the most common type of dermatomycoses and can affect different areas of the body, such as the scalp (tinea capitis), beard (tinea barbae), body (tinea corporis), feet (tinea pedis or athlete's foot), hands (tinea manuum), and nails (tinea unguium or onychomycosis). Yeast infections, such as those caused by Candida albicans, can lead to conditions like candidal intertrigo, vulvovaginitis, and balanitis. Mold infections are less common but can cause skin disorders like scalded skin syndrome and phaeohyphomycosis. Dermatomycoses are typically treated with topical or oral antifungal medications.
Foot dermatoses refer to various skin conditions that affect the feet. These can include inflammatory conditions like eczema and psoriasis, infectious diseases such as athlete's foot (tinea pedis), fungal infections, bacterial infections, viral infections (like plantar warts caused by HPV), and autoimmune blistering disorders. Additionally, contact dermatitis from irritants or allergens can also affect the feet. Proper diagnosis is essential to determine the best course of treatment for each specific condition.
Cutaneous candidiasis is a fungal infection of the skin caused by Candida species, most commonly Candida albicans. The infection can occur anywhere on the skin, but it typically affects warm, moist areas such as the armpits, groin, and fingers. The symptoms of cutaneous candidiasis include redness, itching, burning, and cracking of the skin. In severe cases, pustules or blisters may also be present.
The infection can occur in people of all ages but is more common in those with weakened immune systems, such as individuals with HIV/AIDS, diabetes, or cancer. Other risk factors include obesity, poor hygiene, and the use of certain medications, such as antibiotics and corticosteroids.
Treatment for cutaneous candidiasis typically involves topical antifungal medications, such as clotrimazole or miconazole. In severe cases, oral antifungal medications may be necessary. Keeping the affected area clean and dry is also important to prevent the spread of the infection.
Arthrodermataceae is a family of fungi that includes several medically important dermatophytes, which are fungi that can cause skin and nail infections known as tinea. Some notable genera within this family include:
1. Trichophyton: This genus contains several species that can cause various types of tinea infections, such as athlete's foot (tinea pedis), ringworm (tinea corporis), and jock itch (tinea cruris). Some species can also cause nail infections (tinea unguium or onychomycosis).
2. Microsporum: This genus includes some of the less common causes of tinea infections, such as tinea capitis (scalp ringworm) and tinea corporis.
3. Epidermophyton: This genus contains species that can cause tinea infections of the feet, hands, and nails.
These fungi primarily feed on keratin, a protein found in skin, hair, and nails, and typically invade dead or damaged tissue. Infections caused by Arthrodermataceae are usually treatable with antifungal medications, either topical or oral, depending on the severity and location of the infection.
Tolnaftate is an antifungal medication used to treat various fungal infections such as athlete's foot, jock itch, and ringworm. It works by preventing the growth of fungus. According to the medical definition, Tolnaftate is a synthetic thiocarbamate derivative with antifungal properties. It is available as a cream, powder, spray, or solution for topical application.
It's important to note that Tolnaftate should be used only on the skin and not on mucous membranes or inside the mouth or nose, unless directed by a healthcare professional. Additionally, it may take several days to weeks of using Tolnaftate before symptoms start to improve, and it is important to continue using the medication as directed even after symptoms have improved to ensure that the infection is fully treated.
Tinea favosa, also known as "black dot ringworm," is a chronic and severe form of tinea capitis (ringworm of the scalp). It is caused by the fungus Trichophyton schoenleinii. The name "black dot" refers to the appearance of hair shafts that become broken off at the skin surface, leaving small black dots on the scalp.
The infection often affects children and can cause scaling, alopecia (hair loss), and formation of kerion (a severely inflamed and pustular lesion). The condition is highly contagious and can spread through contact with infected individuals or contaminated objects such as combs, brushes, hats, and towels.
Tinea favosa can be challenging to treat due to its chronic nature and the development of extensive scarring and permanent hair loss if left untreated. Treatment typically involves oral antifungal medications for an extended period, along with proper hygiene measures to prevent the spread of infection.
Griseofulvin is an antifungal medication used to treat various fungal infections, including those affecting the skin, hair, and nails. It works by inhibiting the growth of fungi, particularly dermatophytes, which cause these infections. Griseofulvin can be obtained through a prescription and is available in oral (by mouth) and topical (on the skin) forms.
The primary mechanism of action for griseofulvin involves binding to tubulin, a protein necessary for fungal cell division. This interaction disrupts the formation of microtubules, which are crucial for the fungal cell's structural integrity and growth. As a result, the fungi cannot grow and multiply, allowing the infected tissue to heal and the infection to resolve.
Common side effects associated with griseofulvin use include gastrointestinal symptoms (e.g., nausea, vomiting, diarrhea), headache, dizziness, and skin rashes. It is essential to follow the prescribing physician's instructions carefully when taking griseofulvin, as improper usage may lead to reduced effectiveness or increased risk of side effects.
It is important to note that griseofulvin has limited use in modern medicine due to the development of newer and more effective antifungal agents. However, it remains a valuable option for specific fungal infections, particularly those resistant to other treatments.
Antifungal agents are a type of medication used to treat and prevent fungal infections. These agents work by targeting and disrupting the growth of fungi, which include yeasts, molds, and other types of fungi that can cause illness in humans.
There are several different classes of antifungal agents, including:
1. Azoles: These agents work by inhibiting the synthesis of ergosterol, a key component of fungal cell membranes. Examples of azole antifungals include fluconazole, itraconazole, and voriconazole.
2. Echinocandins: These agents target the fungal cell wall, disrupting its synthesis and leading to fungal cell death. Examples of echinocandins include caspofungin, micafungin, and anidulafungin.
3. Polyenes: These agents bind to ergosterol in the fungal cell membrane, creating pores that lead to fungal cell death. Examples of polyene antifungals include amphotericin B and nystatin.
4. Allylamines: These agents inhibit squalene epoxidase, a key enzyme in ergosterol synthesis. Examples of allylamine antifungals include terbinafine and naftifine.
5. Griseofulvin: This agent disrupts fungal cell division by binding to tubulin, a protein involved in fungal cell mitosis.
Antifungal agents can be administered topically, orally, or intravenously, depending on the severity and location of the infection. It is important to use antifungal agents only as directed by a healthcare professional, as misuse or overuse can lead to resistance and make treatment more difficult.
Microsporum is a genus of fungi belonging to the family Arthrodermataceae. These fungi are known to cause various types of tinea (ringworm) infections in humans and animals. They are characterized by their ability to produce large, thick-walled macroconidia that are typically round to oval in shape.
The most common species of Microsporum that infect humans include M. canis, M. audouinii, and M. gypsum. These fungi are often found in soil and on the skin or fur of animals such as cats, dogs, and cattle. They can cause a variety of skin infections, including tinea capitis (scalp ringworm), tinea corporis (body ringworm), and tinea unguium (nail ringworm).
Microsporum infections are typically treated with topical or oral antifungal medications. Prevention measures include good personal hygiene, avoiding contact with infected animals, and prompt treatment of any fungal infections.