The acquired form of infection by Toxoplasma gondii in animals and man.
Prenatal protozoal infection with TOXOPLASMA gondii which is associated with injury to the developing fetal nervous system. The severity of this condition is related to the stage of pregnancy during which the infection occurs; first trimester infections are associated with a greater degree of neurologic dysfunction. Clinical features include HYDROCEPHALUS; MICROCEPHALY; deafness; cerebral calcifications; SEIZURES; and psychomotor retardation. Signs of a systemic infection may also be present at birth, including fever, rash, and hepatosplenomegaly. (From Adams et al., Principles of Neurology, 6th ed, p735)
Infection caused by the protozoan parasite TOXOPLASMA in which there is extensive connective tissue proliferation, the retina surrounding the lesions remains normal, and the ocular media remain clear. Chorioretinitis may be associated with all forms of toxoplasmosis, but is usually a late sequel of congenital toxoplasmosis. The severe ocular lesions in infants may lead to blindness.
Infections of the BRAIN caused by the protozoan TOXOPLASMA gondii that primarily arise in individuals with IMMUNOLOGIC DEFICIENCY SYNDROMES (see also AIDS-RELATED OPPORTUNISTIC INFECTIONS). The infection may involve the brain diffusely or form discrete abscesses. Clinical manifestations include SEIZURES, altered mentation, headache, focal neurologic deficits, and INTRACRANIAL HYPERTENSION. (From Joynt, Clinical Neurology, 1998, Ch27, pp41-3)
A genus of protozoa parasitic to birds and mammals. T. gondii is one of the most common infectious pathogenic animal parasites of man.
Acquired infection of non-human animals by organisms of the genus TOXOPLASMA.
Inflammation of the choroid in which the sensory retina becomes edematous and opaque. The inflammatory cells and exudate may burst through the sensory retina to cloud the vitreous body.
Immunoglobulins produced in a response to PROTOZOAN ANTIGENS.
One of the short-acting SULFONAMIDES used in combination with PYRIMETHAMINE to treat toxoplasmosis in patients with acquired immunodeficiency syndrome and in newborns with congenital infections.
The co-occurrence of pregnancy and parasitic diseases. The parasitic infection may precede or follow FERTILIZATION.
Substances that are destructive to protozoans.
A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.
Infections of the lungs with parasites, most commonly by parasitic worms (HELMINTHS).
Any part or derivative of any protozoan that elicits immunity; malaria (Plasmodium) and trypanosome antigens are presently the most frequently encountered.
The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
EPIDEMIOLOGIC STUDIES based on the detection through serological testing of characteristic change in the serum level of specific ANTIBODIES. Latent subclinical infections and carrier states can thus be detected in addition to clinically overt cases.
Deoxyribonucleic acid that makes up the genetic material of protozoa.
Opportunistic infections found in patients who test positive for human immunodeficiency virus (HIV). The most common include PNEUMOCYSTIS PNEUMONIA, Kaposi's sarcoma, cryptosporidiosis, herpes simplex, toxoplasmosis, cryptococcosis, and infections with Mycobacterium avium complex, Microsporidium, and Cytomegalovirus.
Inflammation of the choroid.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Diagnostic procedures involving immunoglobulin reactions.
A hydroxynaphthoquinone that has antimicrobial activity and is being used in antimalarial protocols.
Suspensions of attenuated or killed protozoa administered for the prevention or treatment of infectious protozoan disease.
A measure of the binding strength between antibody and a simple hapten or antigen determinant. It depends on the closeness of stereochemical fit between antibody combining sites and antigen determinants, on the size of the area of contact between them, and on the distribution of charged and hydrophobic groups. It includes the concept of "avidity," which refers to the strength of the antigen-antibody bond after formation of reversible complexes.
An infant during the first month after birth.
One of the FOLIC ACID ANTAGONISTS that is used as an antimalarial or with a sulfonamide to treat toxoplasmosis.
Proteins found in any species of protozoan.
The identification of selected parameters in newborn infants by various tests, examinations, or other procedures. Screening may be performed by clinical or laboratory measures. A screening test is designed to sort out healthy neonates (INFANT, NEWBORN) from those not well, but the screening test is not intended as a diagnostic device, rather instead as epidemiologic.
The study of parasites and PARASITIC DISEASES.
Disease having a short and relatively severe course.
I'm sorry for any confusion, but "Brazil" is not a medical term or concept, it is a country located in South America, known officially as the Federative Republic of Brazil. If you have any questions related to health, medicine, or science, I'd be happy to help answer those!
Inflammation of the choroid as well as the retina and vitreous body. Some form of visual disturbance is usually present. The most important characteristics of posterior uveitis are vitreous opacities, choroiditis, and chorioretinitis.
Inflammation of the lymph nodes.
Agents useful in the treatment or prevention of COCCIDIOSIS in man or animals.
The co-occurrence of pregnancy and an INFECTION. The infection may precede or follow FERTILIZATION.
The transmission of infectious disease or pathogens from one generation to another. It includes transmission in utero or intrapartum by exposure to blood and secretions, and postpartum exposure via breastfeeding.
Skin diseases caused by ARTHROPODS; HELMINTHS; or other parasites.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
A human or animal whose immunologic mechanism is deficient because of an immunodeficiency disorder or other disease or as the result of the administration of immunosuppressive drugs or radiation.
Represents 15-20% of the human serum immunoglobulins, mostly as the 4-chain polymer in humans or dimer in other mammals. Secretory IgA (IMMUNOGLOBULIN A, SECRETORY) is the main immunoglobulin in secretions.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
Naphthalene rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups.
Inflammation of the BRAIN due to infection, autoimmune processes, toxins, and other conditions. Viral infections (see ENCEPHALITIS, VIRAL) are a relatively frequent cause of this condition.
The presence of parasites in food and food products. For the presence of bacteria, viruses, and fungi in food, FOOD MICROBIOLOGY is available.
Tests that are dependent on the clumping of cells, microorganisms, or particles when mixed with specific antiserum. (From Stedman, 26th ed)
An antibacterial agent that is a semisynthetic analog of LINCOMYCIN.
Diseases of the domestic cat (Felis catus or F. domesticus). This term does not include diseases of the so-called big cats such as CHEETAHS; LIONS; tigers, cougars, panthers, leopards, and other Felidae for which the heading CARNIVORA is used.
Determination of the nature of a pathological condition or disease in the postimplantation EMBRYO; FETUS; or pregnant female before birth.
A republic in the north of South America, bordered on the west by GUYANA (British Guiana) and on the east by FRENCH GUIANA. Its capital is Paramaribo. It was formerly called Netherlands Guiana or Dutch Guiana or Surinam. Suriname was first settled by the English in 1651 but was ceded to the Dutch by treaty in 1667. It became an autonomous territory under the Dutch crown in 1954 and gained independence in 1975. The country was named for the Surinam River but the meaning of that name is uncertain. (From Webster's New Geographical Dictionary, 1988, p1167 & Room, Brewer's Dictionary of Names, 1992, p526)
The ability of lymphoid cells to mount a humoral or cellular immune response when challenged by antigen.
Inflammation of part or all of the uvea, the middle (vascular) tunic of the eye, and commonly involving the other tunics (sclera and cornea, and the retina). (Dorland, 27th ed)
Zygote-containing cysts of sporozoan protozoa. Further development in an oocyst produces small individual infective organisms called SPOROZOITES. Then, depending on the genus, the entire oocyst is called a sporocyst or the oocyst contains multiple sporocysts encapsulating the sporozoites.
A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*15 allele family.
A mammalian fetus expelled by INDUCED ABORTION or SPONTANEOUS ABORTION.
I'm sorry for any confusion, but "Kyrgyzstan" is not a medical term and does not have a medical definition; it is the name of a country located in Central Asia, known officially as the Kyrgyz Republic.
A clear, yellowish liquid that envelopes the FETUS inside the sac of AMNION. In the first trimester, it is likely a transudate of maternal or fetal plasma. In the second trimester, amniotic fluid derives primarily from fetal lung and kidney. Cells or substances in this fluid can be removed for prenatal diagnostic tests (AMNIOCENTESIS).
Member of the genus Trichechus inhabiting the coast and coastal rivers of the southeastern United States as well as the West Indies and the adjacent mainland from Vera Cruz, Mexico to northern South America. (From Scott, Concise Encyclopedia Biology, 1996)
The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)
An infection caused by an organism which becomes pathogenic under certain conditions, e.g., during immunosuppression.
The clear, watery fluid which fills the anterior and posterior chambers of the eye. It has a refractive index lower than the crystalline lens, which it surrounds, and is involved in the metabolism of the cornea and the crystalline lens. (Cline et al., Dictionary of Visual Science, 4th ed, p319)
Sensitive tests to measure certain antigens, antibodies, or viruses, using their ability to agglutinate certain erythrocytes. (From Stedman, 26th ed)
A technique using antibodies for identifying or quantifying a substance. Usually the substance being studied serves as antigen both in antibody production and in measurement of antibody by the test substance.
Measure of the number of the PARASITES present in a host organism.
A phylum of unicellular parasitic EUKARYOTES characterized by the presence of complex apical organelles generally consisting of a conoid that aids in penetrating host cells, rhoptries that possibly secrete a proteolytic enzyme, and subpellicular microtubules that may be related to motility.
The relationship between an invertebrate and another organism (the host), one of which lives at the expense of the other. Traditionally excluded from definition of parasites are pathogenic BACTERIA; FUNGI; VIRUSES; and PLANTS; though they may live parasitically.
Premature expulsion of the FETUS in animals.
Infections of the brain, spinal cord, or meninges by single celled organisms of the former subkingdom known as protozoa. The central nervous system may be the primary or secondary site of protozoal infection. These diseases may occur as OPPORTUNISTIC INFECTIONS or arise in immunocompetent hosts.
Diseases affecting the eye.
Inflammation of the RETINA. It is rarely limited to the retina, but is commonly associated with diseases of the choroid (CHORIORETINITIS) and of the OPTIC DISK (neuroretinitis).
Animals which have become adapted through breeding in captivity to a life intimately associated with humans. They include animals domesticated by humans to live and breed in a tame condition on farms or ranches for economic reasons, including LIVESTOCK (specifically CATTLE; SHEEP; HORSES; etc.), POULTRY; and those raised or kept for pleasure and companionship, e.g., PETS; or specifically DOGS; CATS; etc.
Techniques used to carry out clinical investigative procedures in the diagnosis and therapy of disease.
Pathophysiological conditions of the FETUS in the UTERUS. Some fetal diseases may be treated with FETAL THERAPIES.
Infections with unicellular organisms formerly members of the subkingdom Protozoa.

Fetal cataract in congenital toxoplasmosis. (1/204)

We report a case of the prenatal diagnosis of fetal cataract due to congenital toxoplasmosis. To the best of our knowledge, this is the first report of such a case. We discuss the long-term ocular sequelae of the condition and how they should affect prenatal counselling.  (+info)

Congenital toxoplasmosis: systematic review of evidence of efficacy of treatment in pregnancy. (2/204)

OBJECTIVE: To summarise the evidence that treating toxoplasmosis in pregnancy reduces the risk of congenital toxoplasma infection and improves infant outcomes. DESIGN: Systematic review of studies comparing at least two concurrent groups of pregnant women with proved or likely acute toxoplasma infection in which treatments were compared with no treatment and outcomes in the children were reported. SUBJECTS: Studies were identified from Medline (1966-97), Pascal (1990-7), Embase (1993-7), and Biological abstracts (1993-5) plus contact with experts in the field, including the European Research Network on Congenital Toxoplasmosis. MAIN OUTCOME MEASURE: Proportion of infected children at 1 year born to infected pregnant women who were or were not treated. RESULTS: Out of 2591 papers identified, nine met the inclusion criteria. There were no randomised comparisons, and control groups were generally not directly comparable with the treatment groups. Congenital infection was common in treated groups. five studies showed that treatment was effective and four that it was not. CONCLUSION: It is unclear whether antenatal treatment in women with presumed toxoplasmosis reduces congenital transmission of Toxoplasma gondii. Screening is expensive, so the effects of treatment and impact of screening programmes need to be evaluated. In countries where screening or treatment is not routine, these technologies should not be introduced outside carefully controlled trials.  (+info)

The ocular manifestations of congenital infection: a study of the early effect and long-term outcome of maternally transmitted rubella and toxoplasmosis. (3/204)

PURPOSE: To study the spectrum of adverse ocular effects which result from maternally transmitted rubella and toxoplasma infection; further, to record the long-term visual and neurodevelopmental outcomes of these 2 major causes of fetal infection. STUDY DESIGN AND PATIENTS: A series of 55 patients with congenital infection have been studied prospectively on a long-term basis. The study group included a cohort of 34 cases with congenital rubella syndrome demonstrated by virus isolation, and 21 cases with a clinical diagnosis of congenital toxoplasmosis and serologic confirmation. All patients had specific disease-related ocular defects. Rubella patients were first identified during or following the last major rubella epidemic in 1963-1964, and some have been followed serially since that time. A separate study group of representative toxoplasmosis patients presented for examination and diagnosis at varying time periods between 1967 and 1991. OBSERVATIONS AND RESULTS: This study confirms that a broad spectrum of fetal injury may result from intrauterine infection and that both persistent and delayed-onset effects may continue or occur as late as 30 years after original infection. Many factors contribute to the varied outcome of prenatal infection, the 2 most important being the presence of maternal immunity during early gestation and the stage of gestation during which fetal exposure occurs in a nonimmune mother. RUBELLA: As a criteria of inclusion, all 34 rubella patients in this study exhibited one or more ocular defects at the time of birth or in the immediate neonatal period. Cataracts were present in 29 (85%) of the 34, of which 21 (63%) were bilateral. Microphthalmia, the next most frequent defect, was present in 28 (82%) of the 34 infants and was bilateral in 22 (65%). Glaucoma was recorded in 11 cases (29%) and presented either as a transient occurrence with early cloudy cornea in microphthalmic eyes (4 patients), as the infantile type with progressive buphthalmos (1 patient), or as a later-onset, aphakic glaucoma many months or years following cataract aspiration in 11 eyes of 6 patients. Rubella retinopathy was present in the majority of patients, although an accurate estimate of its incidence or laterality was not possible because of the frequency of cataracts and nystagmus and the difficulty in obtaining adequate fundus examination. TOXOPLASMOSIS: Twenty-one patients with congenital toxoplasmosis have been examined and followed for varying time periods, 7 for 20 years or more. The major reason for initial examination was parental awareness of an ocular deviation. Twelve children (57%) presented between the ages of 3 months and 4 years with an initial diagnosis of strabismus, 9 of whom had minor complaints or were diagnosed as part of routine examinations. All cases in this study have had evidence of retinochoroiditis, the primary ocular pathology of congenital toxoplasmosis. Two patients had chronic and recurrent inflammation with progressive vitreal traction bands, retinal detachments, and bilateral blindness. Macular lesions were always associated with central vision loss; however, over a period of years visual acuity gradually improved in several patients. Individuals with more severe ocular involvement were also afflicted with the most extensive central nervous system deficits, which occurred following exposure during the earliest weeks of gestation. CONCLUSIONS: Although congenital infection due to rubella virus has been almost completely eradicated in the United States, the long-term survivors from the prevaccination period continue to experience major complications from their early ocular and cerebral defects. They may be afflicted by the persistence of virus in their affected organs and the development of late manifestations of their congenital infection. Congenital toxoplasmosis continues to be the source of major defects for 3,000 to 4,100 infants in the United States each year; the spectrum of defects is wide and may vary from blindness and severe mental retardation to minor retinochoroidal lesions of little consequence. Effective solutions for either the prevention or treatment of congenital toxoplasmosis have not been developed in this country but are under intensive and continuing investigation.  (+info)

Value of prenatal diagnosis and early postnatal diagnosis of congenital toxoplasmosis: retrospective study of 110 cases. (4/204)

We reviewed the files of 110 women with Toxoplasma seroconversion during pregnancy. Prenatal diagnosis was attempted for 94 women by amniotic fluid sampling. Toxoplasma gondii was detected by PCR, with or without tissue culture and mouse inoculation. The early neonatal diagnostic procedure included placental testing by PCR and/or mouse inoculation, cord blood serological testing, and comparison of maternal and newborn antibodies by Western blotting (WB). Serological follow-up of the infants was conducted during the first year of life or until the diagnosis of congenital toxoplasmosis (CT) could be ruled out. Congenital infection was diagnosed in 27 individuals (20 live births) in the prenatal and/or neonatal period. The sensitivity and specificity of prenatal diagnosis were 81 and 100%, respectively. Placental examination was positive for 66.7% of individuals with CT and was always negative for neonates without CT. Cord blood serology detected immunoglobulin M (IgM) and/or IgA in 80% of infected newborns, with respective specificities of 91.2 and 87.7%. By WB we detected bands on IgG and IgM blots recognized by the newborn serum but not by the maternal serum (neosynthesized IgG and/or IgM) for 88.2% of infected infants within the first 2 months of life with a specificity of 100%. Early postnatal diagnosis was negative for 2 of the 20 neonates with CT. Both of these newborns had a negative prenatal diagnosis and were asymptomatic, suggesting a very low parasite load. In conclusion, despite the use of advanced methods, some cases of congenital toxoplasmosis cannot be detected early, which underlines the importance of careful follow-up of newborns who are at risk.  (+info)

A switch towards Th2 during serological rebound in children with congenital toxoplasmosis. (5/204)

Serological rebounds occur frequently in patients with congenital toxoplasmosis, but remain poorly understood. A link between Th1 and Th2 cytokines and the pathophysiology of infectious diseases has been reported. Production of interferon-gamma (IFN-gamma) and IL-4 in supernatants of whole blood after in vitro specific Toxoplasma gondii stimulation and serum-specific IgE levels were studied in 31 congenitally infected children. IFN-gamma was produced at higher levels by lymphocytes from children with stable congenital toxoplasmosis (n = 18) than from children showing serological rebound (n = 13) (P < 0.04). Conversely, supernatants from children with serological rebound showed higher levels of IL-4 than those from children with stable congenital toxoplasmosis (P < 0.03). The polarized Th2 response was confirmed by a greater (IL-4:IFN-gamma) x 100 ratio (P < 0.0001) and production of T. gondii-specific IgE in six out of 13 children showing serological rebound. These results suggest a role of Th2 cytokines in destabilization of congenital toxoplasmosis and perhaps in local reactivation of the parasite.  (+info)

Detection of specific immunoglobulin E during maternal, fetal, and congenital toxoplasmosis. (6/204)

Toxoplasma immunoglobulin E (IgE) antibodies in 664 serum samples were evaluated by using an immunocapture method with a suspension of tachyzoites prepared in the laboratory in order to evaluate its usefulness in the diagnosis of acute Toxoplasma gondii infection during pregnancy, congenital infection, and progressive toxoplasmosis. IgE antibodies were never detected in sera from seronegative women, from patients with chronic toxoplasma infection, or from infants without congenital toxoplasmosis. In contrast, they were detected in 86.6% of patients with toxoplasmic seroconversion, and compared with IgA and IgM, the short kinetics of IgE was useful to date the infection precisely. For the diagnosis of congenital toxoplasmosis, specific IgE detected was less frequently than IgM or IgA (25 versus 67.3%), but its detection during follow-up of children may be interesting, reflecting an immunological rebound. Finally, IgE was detected early and persisted longer in progressive toxoplasmosis with cervical adenopathies, so it was also a good marker of the evolution of toxoplasma infection.  (+info)

Experimental toxoplasmosis in Balb/c mice. Prevention of vertical disease transmission by treatment and reproductive failure in chronic infection. (7/204)

In a study of congenital transmission during acute infection of Toxoplasma gondii, 23 pregnant Balb/c mice were inoculated orally with two cysts each of the P strain. Eight mice were inoculated 6-11 days after becoming pregnant (Group 1). Eight mice inoculated on the 10th-15th day of pregnancy (Group 2) were treated with 100 mg/kg/day of minocycline 48 h after inoculation. Seven mice inoculated on the 10th-15th day of pregnancy were not treated and served as a control (Group 3). Congenital transmission was evaluated through direct examination of the brains of the pups or by bioassay and serologic tests. Congenital transmission was observed in 20 (60.6%) of the 33 pups of Group 1, in one (3.6%) of the 28 pups of Group 2, and in 13 (54.2%) of the 24 pups of Group 3. Forty-nine Balb/c mice were examined in the study of congenital transmission of T. gondii during chronic infection. The females showed reproductive problems during this phase of infection. It was observed accentuated hypertrophy of the endometrium and myometrium. Only two of the females gave birth. Our results demonstrate that Balb/c mice with acute toxoplasmosis can be used as a model for studies of congenital T. gondii infection. Our observations indicate the potential of this model for testing new chemotherapeutic agents against congenital toxoplasmosis.  (+info)

Discrimination between patients with acquired toxoplasmosis and congenital toxoplasmosis on the basis of the immune response to parasite antigens. (8/204)

Many persons infected with Toxoplasma gondii develop ocular lesions. Immunologic parameters in the response to T. gondii were evaluated in infected persons with and without ocular lesions and in noninfected controls. Subjects were divided into groups on the basis of presence of serum antibodies to T. gondii, presence of ocular lesions, and clinical history. Production of interleukin-2 and interferon-gamma by peripheral blood mononuclear cells from patients with probable congenital toxoplasmosis was decreased, compared with that in persons with presumed acquired infection. Cell proliferation and delayed-type skin reaction induced by soluble toxoplasma tachyzoite antigen followed the same pattern. Asymptomatic persons showed high levels of interleukin-12 and interferon-gamma, whereas persons with ocular lesions had high interleukin-1 and tumor necrosis factor-alpha responses toward soluble toxoplasma tachyzoite antigen. These data suggest that patients with ocular disease due to congenital infection show tolerance toward the parasite. Furthermore, susceptibility to ocular lesions after acquired toxoplasmosis is associated with high levels of interleukin-1 and tumor necrosis factor-alpha, whereas resistance is associated with high levels of interleukin-12 and interferon-gamma.  (+info)

Toxoplasmosis is a disease caused by the parasitic protozoan Toxoplasma gondii. It can infect humans, birds, and most warm-blooded animals, including marine mammals. In humans, it is usually contracted through eating undercooked, contaminated meat or ingesting oocysts (a form of the parasite) from cat feces, often through contact with litter boxes or gardening in soil that has been contaminated with cat feces.

The infection can also be passed to the fetus if a woman becomes infected during or just before pregnancy. Most healthy individuals who become infected with Toxoplasma gondii experience few symptoms and are not aware they have the disease. However, for those with weakened immune systems, such as people with HIV/AIDS, organ transplant recipients, and pregnant women, toxoplasmosis can cause severe complications, including damage to the brain, eyes, and other organs.

Symptoms of toxoplasmosis in individuals with weakened immune systems may include swollen lymph nodes, fever, fatigue, muscle aches, and headache. In pregnant women, infection can lead to miscarriage, stillbirth, or severe developmental problems in the baby. Treatment typically involves antiparasitic medications such as pyrimethamine and sulfadiazine.

Congenital toxoplasmosis is a medical condition that results from the transmission of the Toxoplasma gondii parasite from an infected pregnant woman to her developing fetus through the placenta. The severity of the infection can vary widely, depending on the stage of pregnancy at which the mother becomes infected.

Infection during early pregnancy is associated with a higher risk of severe symptoms in the newborn, including:

* Intracranial calcifications
* Hydrocephalus (fluid buildup in the brain)
* Microcephaly (abnormally small head)
* Chorioretinitis (inflammation of the eye's retina and choroid layer)
* Seizures
* Developmental delays
* Hearing loss

Infection later in pregnancy may result in less severe symptoms or be asymptomatic at birth, but can still lead to developmental delays, learning disabilities, and vision problems as the child grows.

Diagnosis of congenital toxoplasmosis typically involves a combination of tests, such as blood tests to detect antibodies against Toxoplasma gondii, imaging studies (e.g., ultrasound, CT, or MRI) to assess any structural abnormalities in the brain and other organs, and ophthalmologic examinations to evaluate potential eye damage.

Treatment for congenital toxoplasmosis usually involves a combination of antiparasitic medications (such as spiramycin, pyrimethamine, and sulfadiazine) and corticosteroids to reduce inflammation. Early treatment can help minimize the severity of symptoms and improve outcomes for affected children.

Ocular toxoplasmosis is an inflammatory eye disease caused by the parasitic infection of Toxoplasma gondii in the eye's retina. It can lead to lesions and scarring in the retina, resulting in vision loss or impairment. The severity of ocular toxoplasmosis depends on the location and extent of the infection in the eye. In some cases, it may cause only mild symptoms, while in others, it can result in severe damage to the eye. Ocular toxoplasmosis is usually treated with medications that target the Toxoplasma gondii parasite, such as pyrimethamine and sulfadiazine, often combined with corticosteroids to reduce inflammation.

Cerebral toxoplasmosis is a type of toxoplasmosis, which is an infection caused by the Toxoplasma gondii parasite. In cerebral toxoplasmosis, the infection primarily affects the brain, leading to inflammation and the formation of lesions or abscesses in the brain tissue.

This condition is most commonly observed in individuals with weakened immune systems, such as those living with HIV/AIDS, receiving immunosuppressive therapy after organ transplantation, or having other conditions that compromise their immune function. The infection can cause a range of neurological symptoms, including headaches, seizures, confusion, memory loss, poor coordination, and in severe cases, coma or even death. Early diagnosis and treatment with appropriate antiparasitic medications are crucial to manage the infection and prevent complications.

"Toxoplasma" is a genus of protozoan parasites, and the most well-known species is "Toxoplasma gondii." This particular species is capable of infecting virtually all warm-blooded animals, including humans. It's known for its complex life cycle that involves felines (cats) as the definitive host.

Infection in humans, called toxoplasmosis, often occurs through ingestion of contaminated food or water, or through contact with cat feces that contain T. gondii oocysts. While many people infected with Toxoplasma show no symptoms, it can cause serious health problems in immunocompromised individuals and developing fetuses if a woman becomes infected during pregnancy.

It's important to note that while I strive to provide accurate information, this definition should not be used for self-diagnosis or treatment. Always consult with a healthcare professional for medical advice.

Toxoplasmosis is a zoonotic disease, meaning it can be transmitted from animals to humans. It is caused by the intracellular protozoan parasite Toxoplasma gondii. This parasite can infect a wide range of warm-blooded animals, including birds and mammals, as intermediate hosts. However, cats are the primary definitive host for this parasite because the sexual stage of the parasite's life cycle occurs in their intestines, leading to the shedding of oocysts (environmentally resistant stages) in their feces.

Animals can become infected with Toxoplasma gondii through several routes:

1. Ingestion of sporulated oocysts from contaminated soil, water, or food.
2. Consumption of tissue cysts present in the tissues of infected animals during predation.
3. Vertical transmission (transplacental) from an infected mother to her offspring.

Clinical signs and symptoms of toxoplasmosis in animals can vary depending on their age, immune status, and the parasite's virulence. In many cases, animals may not show any apparent signs of infection, but some may develop:

1. Generalized illness with fever, lethargy, and loss of appetite.
2. Lymphadenopathy (swollen lymph nodes).
3. Neurological symptoms such as tremors, ataxia (lack of coordination), or seizures if the central nervous system is affected.
4. Eye lesions, including inflammation and scarring of the retina, which can lead to vision loss in severe cases.
5. Reproductive issues, such as abortion, stillbirths, or birth defects in offspring when pregnant females are infected.

It is important to note that while toxoplasmosis can cause significant health problems in animals, particularly in immunocompromised individuals and developing fetuses, it is often asymptomatic or mild in healthy adult animals. Nonetheless, the zoonotic potential of Toxoplasma gondii highlights the importance of practicing good hygiene and taking necessary precautions when handling infected animals or their waste to minimize the risk of transmission to humans.

Chorioretinitis is a medical term that refers to the inflammation of the choroid and the retina, which are both important structures in the eye. The choroid is a layer of blood vessels that supplies oxygen and nutrients to the retina, while the retina is a light-sensitive tissue that converts light into electrical signals that are sent to the brain and interpreted as visual images.

Chorioretinitis can be caused by various infectious and non-infectious conditions, such as bacterial, viral, fungal, or parasitic infections, autoimmune diseases, or cancer. The symptoms of chorioretinitis may include decreased vision, floaters, blurry vision, sensitivity to light, and eye pain. Treatment for chorioretinitis depends on the underlying cause and may include antibiotics, antiviral medications, corticosteroids, or other immunosuppressive therapies. It is important to seek medical attention promptly if you experience any symptoms of chorioretinitis, as timely diagnosis and treatment can help prevent permanent vision loss.

Antibodies, protozoan, refer to the immune system's response to an infection caused by a protozoan organism. Protozoa are single-celled microorganisms that can cause various diseases in humans, such as malaria, giardiasis, and toxoplasmosis.

When the body is infected with a protozoan, the immune system responds by producing specific proteins called antibodies. Antibodies are produced by a type of white blood cell called a B-cell, and they recognize and bind to specific antigens on the surface of the protozoan organism.

There are five main types of antibodies: IgA, IgD, IgE, IgG, and IgM. Each type of antibody has a different role in the immune response. For example, IgG is the most common type of antibody and provides long-term immunity to previously encountered pathogens. IgM is the first antibody produced in response to an infection and is important for activating the complement system, which helps to destroy the protozoan organism.

Overall, the production of antibodies against protozoan organisms is a critical part of the immune response and helps to protect the body from further infection.

Sulfadiazine is an antibacterial drug, specifically a sulfonamide. It is chemically described as 4-amino-N-(2-pyrimidinyl)benzenesulfonamide. Sulfadiazine works by inhibiting the bacterial synthesis of dihydrofolic acid, which is essential for bacterial growth and reproduction.

It is used to treat a wide range of infections caused by susceptible bacteria, including urinary tract infections, respiratory infections, and certain types of meningitis. Sulfadiazine is often combined with other antibiotics, such as trimethoprim, to increase its effectiveness against certain bacteria.

Like all sulfonamides, sulfadiazine can cause side effects, including skin rashes, allergic reactions, and stomach upset. It should be used with caution in people who are allergic to sulfa drugs or have kidney or liver disease. Additionally, it is important to note that the use of sulfonamides during pregnancy, especially during the third trimester, should be avoided due to the risk of kernicterus in the newborn.

Parasitic pregnancy complications refer to a rare condition where a parasitic twin takes over the development of the dominant twin's reproductive system and becomes pregnant. This condition is also known as fetus in fetu or vanishing twin syndrome with a parasitic twin. The parasitic twin may have some organs developed, but it is not fully formed and relies on the dominant twin for survival. The pregnancy can pose risks to the dominant twin, such as abnormal growth patterns, organ damage, and complications during childbirth. This condition is usually detected during prenatal ultrasound examinations.

Antiprotozoal agents are a type of medication used to treat protozoal infections, which are infections caused by microscopic single-celled organisms called protozoa. These agents work by either killing the protozoa or inhibiting their growth and reproduction. They can be administered through various routes, including oral, topical, and intravenous, depending on the type of infection and the severity of the illness.

Examples of antiprotozoal agents include:

* Metronidazole, tinidazole, and nitazoxanide for treating infections caused by Giardia lamblia and Entamoeba histolytica.
* Atovaquone, clindamycin, and pyrimethamine-sulfadoxine for treating malaria caused by Plasmodium falciparum or other Plasmodium species.
* Pentamidine and suramin for treating African trypanosomiasis (sleeping sickness) caused by Trypanosoma brucei gambiense or T. b. rhodesiense.
* Nitroimidazoles, such as benznidazole and nifurtimox, for treating Chagas disease caused by Trypanosoma cruzi.
* Sodium stibogluconate and paromomycin for treating leishmaniasis caused by Leishmania species.

Antiprotozoal agents can have side effects, ranging from mild to severe, depending on the drug and the individual patient's response. It is essential to follow the prescribing physician's instructions carefully when taking these medications and report any adverse reactions promptly.

Immunoglobulin M (IgM) is a type of antibody that is primarily found in the blood and lymph fluid. It is the first antibody to be produced in response to an initial exposure to an antigen, making it an important part of the body's primary immune response. IgM antibodies are large molecules that are composed of five basic units, giving them a pentameric structure. They are primarily found on the surface of B cells as membrane-bound immunoglobulins (mlgM), where they function as receptors for antigens. Once an mlgM receptor binds to an antigen, it triggers the activation and differentiation of the B cell into a plasma cell that produces and secretes large amounts of soluble IgM antibodies.

IgM antibodies are particularly effective at agglutination (clumping) and complement activation, which makes them important in the early stages of an immune response to help clear pathogens from the bloodstream. However, they are not as stable or long-lived as other types of antibodies, such as IgG, and their levels tend to decline after the initial immune response has occurred.

In summary, Immunoglobulin M (IgM) is a type of antibody that plays a crucial role in the primary immune response to antigens by agglutination and complement activation. It is primarily found in the blood and lymph fluid, and it is produced by B cells after they are activated by an antigen.

Parasitic lung diseases refer to conditions caused by infection of the lungs by parasites. These are small organisms that live on or in a host organism and derive their sustenance at the expense of the host. Parasitic lung diseases can be caused by various types of parasites, including helminths (worms) and protozoa.

Examples of parasitic lung diseases include:

1. Pulmonary echinococcosis (hydatid disease): This is a rare infection caused by the larval stage of the tapeworm Echinococcus granulosus. The larvae form cysts in various organs, including the lungs.
2. Paragonimiasis: This is a food-borne lung fluke infection caused by Paragonimus westermani and other species. Humans become infected by eating raw or undercooked crustaceans (such as crabs or crayfish) that contain the larval stage of the parasite.
3. Toxocariasis: This is a soil-transmitted helminth infection caused by the roundworm Toxocara canis or T. cati, which are found in the intestines of dogs and cats. Humans become infected through accidental ingestion of contaminated soil, undercooked meat, or through contact with an infected animal's feces. Although the primary site of infection is the small intestine, larval migration can lead to lung involvement in some cases.
4. Amebic lung disease: This is a rare complication of amebiasis, which is caused by the protozoan Entamoeba histolytica. The parasite usually infects the large intestine, but it can spread to other organs, including the lungs, through the bloodstream.
5. Cryptosporidiosis: This is a waterborne protozoan infection caused by Cryptosporidium parvum or C. hominis. Although the primary site of infection is the small intestine, immunocompromised individuals can develop disseminated disease, including pulmonary involvement.

Symptoms of parasitic lung diseases vary depending on the specific organism and the severity of infection but may include cough, chest pain, shortness of breath, fever, and sputum production. Diagnosis typically involves a combination of clinical evaluation, imaging studies, and laboratory tests, such as stool or blood examinations for parasites or their antigens. Treatment depends on the specific organism but may include antiparasitic medications, supportive care, and management of complications.

Antigens are substances (usually proteins) found on the surface of cells, or viruses, that can be recognized by the immune system and stimulate an immune response. In the context of protozoa, antigens refer to the specific proteins or other molecules found on the surface of these single-celled organisms that can trigger an immune response in a host organism.

Protozoa are a group of microscopic eukaryotic organisms that include a diverse range of species, some of which can cause diseases in humans and animals. When a protozoan infects a host, the host's immune system recognizes the protozoan antigens as foreign and mounts an immune response to eliminate the infection. This response involves the activation of various types of immune cells, such as T-cells and B-cells, which recognize and target the protozoan antigens.

Understanding the nature of protozoan antigens is important for developing vaccines and other immunotherapies to prevent or treat protozoan infections. For example, researchers have identified specific antigens on the surface of the malaria parasite that are recognized by the human immune system and have used this information to develop vaccine candidates. However, many protozoan infections remain difficult to prevent or treat, and further research is needed to identify new targets for vaccines and therapies.

Immunoglobulin G (IgG) is a type of antibody, which is a protective protein produced by the immune system in response to foreign substances like bacteria or viruses. IgG is the most abundant type of antibody in human blood, making up about 75-80% of all antibodies. It is found in all body fluids and plays a crucial role in fighting infections caused by bacteria, viruses, and toxins.

IgG has several important functions:

1. Neutralization: IgG can bind to the surface of bacteria or viruses, preventing them from attaching to and infecting human cells.
2. Opsonization: IgG coats the surface of pathogens, making them more recognizable and easier for immune cells like neutrophils and macrophages to phagocytose (engulf and destroy) them.
3. Complement activation: IgG can activate the complement system, a group of proteins that work together to help eliminate pathogens from the body. Activation of the complement system leads to the formation of the membrane attack complex, which creates holes in the cell membranes of bacteria, leading to their lysis (destruction).
4. Antibody-dependent cellular cytotoxicity (ADCC): IgG can bind to immune cells like natural killer (NK) cells and trigger them to release substances that cause target cells (such as virus-infected or cancerous cells) to undergo apoptosis (programmed cell death).
5. Immune complex formation: IgG can form immune complexes with antigens, which can then be removed from the body through various mechanisms, such as phagocytosis by immune cells or excretion in urine.

IgG is a critical component of adaptive immunity and provides long-lasting protection against reinfection with many pathogens. It has four subclasses (IgG1, IgG2, IgG3, and IgG4) that differ in their structure, function, and distribution in the body.

Seroepidemiologic studies are a type of epidemiological study that measures the presence and levels of antibodies in a population's blood serum to investigate the prevalence, distribution, and transmission of infectious diseases. These studies help to identify patterns of infection and immunity within a population, which can inform public health policies and interventions.

Seroepidemiologic studies typically involve collecting blood samples from a representative sample of individuals in a population and testing them for the presence of antibodies against specific pathogens. The results are then analyzed to estimate the prevalence of infection and immunity within the population, as well as any factors associated with increased or decreased risk of infection.

These studies can provide valuable insights into the spread of infectious diseases, including emerging and re-emerging infections, and help to monitor the effectiveness of vaccination programs. Additionally, seroepidemiologic studies can also be used to investigate the transmission dynamics of infectious agents, such as identifying sources of infection or tracking the spread of antibiotic resistance.

There doesn't seem to be a specific medical definition for "DNA, protozoan" as it is simply a reference to the DNA found in protozoa. Protozoa are single-celled eukaryotic organisms that can be found in various environments such as soil, water, and the digestive tracts of animals.

Protozoan DNA refers to the genetic material present in these organisms. It is composed of nucleic acids, including deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), which contain the instructions for the development, growth, and reproduction of the protozoan.

The DNA in protozoa, like in other organisms, is made up of two strands of nucleotides that coil together to form a double helix. The four nucleotide bases that make up protozoan DNA are adenine (A), thymine (T), guanine (G), and cytosine (C). These bases pair with each other to form the rungs of the DNA ladder, with A always pairing with T and G always pairing with C.

The genetic information stored in protozoan DNA is encoded in the sequence of these nucleotide bases. This information is used to synthesize proteins, which are essential for the structure and function of the organism's cells. Protozoan DNA also contains other types of genetic material, such as regulatory sequences that control gene expression and repetitive elements with no known function.

Understanding the DNA of protozoa is important for studying their biology, evolution, and pathogenicity. It can help researchers develop new treatments for protozoan diseases and gain insights into the fundamental principles of genetics and cellular function.

AIDS-related opportunistic infections (AROIs) are infections that occur more frequently or are more severe in people with weakened immune systems, such as those with advanced HIV infection or AIDS. These infections take advantage of a weakened immune system and can affect various organs and systems in the body.

Common examples of AROIs include:

1. Pneumocystis pneumonia (PCP), caused by the fungus Pneumocystis jirovecii
2. Mycobacterium avium complex (MAC) infection, caused by a type of bacteria called mycobacteria
3. Candidiasis, a fungal infection that can affect various parts of the body, including the mouth, esophagus, and genitals
4. Toxoplasmosis, caused by the parasite Toxoplasma gondii
5. Cryptococcosis, a fungal infection that affects the lungs and central nervous system
6. Cytomegalovirus (CMV) infection, caused by a type of herpes virus
7. Tuberculosis (TB), caused by the bacterium Mycobacterium tuberculosis
8. Cryptosporidiosis, a parasitic infection that affects the intestines
9. Progressive multifocal leukoencephalopathy (PML), a viral infection that affects the brain

Preventing and treating AROIs is an important part of managing HIV/AIDS, as they can cause significant illness and even death in people with weakened immune systems. Antiretroviral therapy (ART) is used to treat HIV infection and prevent the progression of HIV to AIDS, which can help reduce the risk of opportunistic infections. In addition, medications to prevent specific opportunistic infections may be prescribed for people with advanced HIV or AIDS.

Choroiditis is an inflammatory condition that affects the choroid, a layer of blood vessels in the eye located between the retina (the light-sensitive tissue at the back of the eye) and the sclera (the white outer coat of the eye). The choroid provides oxygen and nutrients to the outer layers of the retina.

Choroiditis is characterized by spots or patches of inflammation in the choroid, which can lead to damage and scarring of the tissue. This can result in vision loss if it affects the macula (the central part of the retina responsible for sharp, detailed vision). Symptoms of choroiditis may include blurred vision, floaters, sensitivity to light, and decreased color perception.

There are several types of choroiditis, including:

1. Multifocal choroiditis: This type is characterized by multiple, small areas of inflammation in the choroid, often accompanied by scarring. It can affect both eyes and may cause vision loss if it involves the macula.
2. Serpiginous choroiditis: This is a chronic, relapsing form of choroiditis that affects the outer layers of the retina and the choroid. It typically causes well-defined, wavy or serpentine-shaped lesions in the posterior pole (the back part) of the eye.
3. Birdshot chorioretinopathy: This is a rare form of choroiditis that primarily affects the peripheral retina and choroid. It is characterized by multiple, cream-colored or yellowish spots throughout the fundus (the interior surface of the eye).
4. Sympathetic ophthalmia: This is a rare condition that occurs when one eye is injured, leading to inflammation in both eyes. The choroid and other structures in the uninjured eye become inflamed due to an autoimmune response.
5. Vogt-Koyanagi-Harada (VKH) disease: This is a multisystemic autoimmune disorder that affects the eyes, skin, hair, and inner ear. In the eye, it causes choroiditis, retinal inflammation, and sometimes optic nerve swelling.

Treatment for choroiditis depends on the underlying cause and may include corticosteroids, immunosuppressive medications, or biologic agents to control inflammation. In some cases, laser therapy or surgery might be necessary to address complications such as retinal detachment or cataracts.

Pregnancy is a physiological state or condition where a fertilized egg (zygote) successfully implants and grows in the uterus of a woman, leading to the development of an embryo and finally a fetus. This process typically spans approximately 40 weeks, divided into three trimesters, and culminates in childbirth. Throughout this period, numerous hormonal and physical changes occur to support the growing offspring, including uterine enlargement, breast development, and various maternal adaptations to ensure the fetus's optimal growth and well-being.

An Enzyme-Linked Immunosorbent Assay (ELISA) is a type of analytical biochemistry assay used to detect and quantify the presence of a substance, typically a protein or peptide, in a liquid sample. It takes its name from the enzyme-linked antibodies used in the assay.

In an ELISA, the sample is added to a well containing a surface that has been treated to capture the target substance. If the target substance is present in the sample, it will bind to the surface. Next, an enzyme-linked antibody specific to the target substance is added. This antibody will bind to the captured target substance if it is present. After washing away any unbound material, a substrate for the enzyme is added. If the enzyme is present due to its linkage to the antibody, it will catalyze a reaction that produces a detectable signal, such as a color change or fluorescence. The intensity of this signal is proportional to the amount of target substance present in the sample, allowing for quantification.

ELISAs are widely used in research and clinical settings to detect and measure various substances, including hormones, viruses, and bacteria. They offer high sensitivity, specificity, and reproducibility, making them a reliable choice for many applications.

Serologic tests are laboratory tests that detect the presence or absence of antibodies or antigens in a patient's serum (the clear liquid that separates from clotted blood). These tests are commonly used to diagnose infectious diseases, as well as autoimmune disorders and other medical conditions.

In serologic testing for infectious diseases, a sample of the patient's blood is collected and allowed to clot. The serum is then separated from the clot and tested for the presence of antibodies that the body has produced in response to an infection. The test may be used to identify the specific type of infection or to determine whether the infection is active or has resolved.

Serologic tests can also be used to diagnose autoimmune disorders, such as rheumatoid arthritis and lupus, by detecting the presence of antibodies that are directed against the body's own tissues. These tests can help doctors confirm a diagnosis and monitor the progression of the disease.

It is important to note that serologic tests are not always 100% accurate and may produce false positive or false negative results. Therefore, they should be interpreted in conjunction with other clinical findings and laboratory test results.

Atovaquone is an antiprotozoal medication used for the treatment and prevention of certain parasitic infections. It works by inhibiting the mitochondria of the parasites, disrupting their energy production and ultimately leading to their death. Atovaquone is available as a oral suspension or coated tablets and is often prescribed for conditions such as Pneumocystis pneumonia (PCP), Toxoplasma gondii encephalitis, and babesiosis. It is also used for the prevention of PCP in people with weakened immune systems due to HIV/AIDS or other causes.

The medical definition of Atovaquone can be stated as:

"Atovaquone is an antiprotozoal medication (synthetic hydroxynaphthoquinone) that exhibits activity against a variety of protozoa, including Plasmodium falciparum (the parasite responsible for malaria), Pneumocystis jirovecii (the causative agent of PCP), Toxoplasma gondii, and Babesia microti. It is used primarily for the treatment and prevention of PCP in individuals with compromised immune systems, as well as for the treatment of babesiosis and toxoplasmosis."

There is no medical definition for "Protozoan Vaccines" as such because there are currently no licensed vaccines available for human protozoan diseases. Protozoa are single-celled microorganisms that can cause various diseases in humans, such as malaria, toxoplasmosis, and leishmaniasis.

Researchers have been working on developing vaccines against some of these diseases, but none have yet been approved for use in humans. Therefore, it is not possible to provide a medical definition for "Protozoan Vaccines" as a recognized category of vaccines.

Antibody affinity refers to the strength and specificity of the interaction between an antibody and its corresponding antigen at a molecular level. It is a measure of how strongly and selectively an antibody binds to its target antigen. A higher affinity indicates a more stable and specific binding, while a lower affinity suggests weaker and less specific interactions. Affinity is typically measured in terms of the dissociation constant (Kd), which describes the concentration of antigen needed to achieve half-maximal binding to an antibody. Generally, a smaller Kd value corresponds to a higher affinity, indicating a tighter and more selective bond. This parameter is crucial in the development of diagnostic and therapeutic applications, such as immunoassays and targeted therapies, where high-affinity antibodies are preferred for improved sensitivity and specificity.

A newborn infant is a baby who is within the first 28 days of life. This period is also referred to as the neonatal period. Newborns require specialized care and attention due to their immature bodily systems and increased vulnerability to various health issues. They are closely monitored for signs of well-being, growth, and development during this critical time.

Pyrimethamine is an antiparasitic medication that is primarily used to treat and prevent protozoan infections, such as toxoplasmosis and malaria. It works by inhibiting the dihydrofolate reductase enzyme, which is essential for the parasite's survival. By doing so, it interferes with the synthesis of folate, a vital component for the growth and reproduction of the parasite.

Pyrimethamine is often used in combination with other medications, such as sulfonamides or sulfones, to increase its effectiveness and prevent the development of drug-resistant strains. Common side effects of pyrimethamine include nausea, vomiting, loss of appetite, and headache. It is important to note that pyrimethamine should only be used under the supervision of a healthcare professional due to its potential for serious side effects and interactions with other medications.

I'm sorry for any confusion, but "Protozoan Proteins" is not a specific medical or scientific term. Protozoa are single-celled eukaryotic organisms, and proteins are large biological molecules consisting of one or more chains of amino acid residues. Therefore, "Protozoan Proteins" generally refers to the various types of proteins found in protozoa.

However, if you're looking for information about proteins specific to certain protozoan parasites with medical relevance (such as Plasmodium falciparum, which causes malaria), I would be happy to help! Please provide more context or specify the particular protozoan of interest.

Neonatal screening is a medical procedure in which specific tests are performed on newborn babies within the first few days of life to detect certain congenital or inherited disorders that are not otherwise clinically apparent at birth. These conditions, if left untreated, can lead to serious health problems, developmental delays, or even death.

The primary goal of neonatal screening is to identify affected infants early so that appropriate treatment and management can be initiated as soon as possible, thereby improving their overall prognosis and quality of life. Commonly screened conditions include phenylketonuria (PKU), congenital hypothyroidism, galactosemia, maple syrup urine disease, sickle cell disease, cystic fibrosis, and hearing loss, among others.

Neonatal screening typically involves collecting a small blood sample from the infant's heel (heel stick) or through a dried blood spot card, which is then analyzed using various biochemical, enzymatic, or genetic tests. In some cases, additional tests such as hearing screenings and pulse oximetry for critical congenital heart disease may also be performed.

It's important to note that neonatal screening is not a diagnostic tool but rather an initial step in identifying infants who may be at risk of certain conditions. Positive screening results should always be confirmed with additional diagnostic tests before any treatment decisions are made.

Parasitology is a branch of biology that deals with the study of parasites, their life cycles, the relationship between parasites and their hosts, the transmission of parasitic diseases, and the development of methods for their control and elimination. It involves understanding various types of parasites including protozoa, helminths, and arthropods that can infect humans, animals, and plants. Parasitologists also study the evolution, genetics, biochemistry, and ecology of parasites to develop effective strategies for their diagnosis, treatment, and prevention.

An acute disease is a medical condition that has a rapid onset, develops quickly, and tends to be short in duration. Acute diseases can range from minor illnesses such as a common cold or flu, to more severe conditions such as pneumonia, meningitis, or a heart attack. These types of diseases often have clear symptoms that are easy to identify, and they may require immediate medical attention or treatment.

Acute diseases are typically caused by an external agent or factor, such as a bacterial or viral infection, a toxin, or an injury. They can also be the result of a sudden worsening of an existing chronic condition. In general, acute diseases are distinct from chronic diseases, which are long-term medical conditions that develop slowly over time and may require ongoing management and treatment.

Examples of acute diseases include:

* Acute bronchitis: a sudden inflammation of the airways in the lungs, often caused by a viral infection.
* Appendicitis: an inflammation of the appendix that can cause severe pain and requires surgical removal.
* Gastroenteritis: an inflammation of the stomach and intestines, often caused by a viral or bacterial infection.
* Migraine headaches: intense headaches that can last for hours or days, and are often accompanied by nausea, vomiting, and sensitivity to light and sound.
* Myocardial infarction (heart attack): a sudden blockage of blood flow to the heart muscle, often caused by a buildup of plaque in the coronary arteries.
* Pneumonia: an infection of the lungs that can cause coughing, chest pain, and difficulty breathing.
* Sinusitis: an inflammation of the sinuses, often caused by a viral or bacterial infection.

It's important to note that while some acute diseases may resolve on their own with rest and supportive care, others may require medical intervention or treatment to prevent complications and promote recovery. If you are experiencing symptoms of an acute disease, it is always best to seek medical attention to ensure proper diagnosis and treatment.

I apologize, but "Brazil" is not a medical term or condition. It is the largest country in both South America and Latin America by land area and population. If you have any questions related to medical terminology or health concerns, please provide more information and I will do my best to help.

Posterior uveitis is a type of uveitis that specifically affects the back portion of the uvea, which includes the choroid (a layer of blood vessels that provides nutrients to the outer layers of the retina), the retina (the light-sensitive tissue at the back of the eye), and the optic nerve (which carries visual information from the eye to the brain).

Posterior uveitis can cause symptoms such as blurred vision, floaters, sensitivity to light, and decreased vision. It may also lead to complications such as retinal scarring, cataracts, glaucoma, and retinal detachment if left untreated. The condition can be caused by a variety of factors, including infections, autoimmune diseases, and trauma. Treatment typically involves the use of corticosteroids or other immunosuppressive medications to reduce inflammation and prevent complications.

Lymphadenitis is a medical term that refers to the inflammation of one or more lymph nodes, which are small, bean-shaped glands that are part of the body's immune system. Lymph nodes contain white blood cells called lymphocytes, which help fight infection and disease.

Lymphadenitis can occur as a result of an infection in the area near the affected lymph node or as a result of a systemic infection that has spread through the bloodstream. The inflammation causes the lymph node to become swollen, tender, and sometimes painful to the touch.

The symptoms of lymphadenitis may include fever, fatigue, and redness or warmth in the area around the affected lymph node. In some cases, the overlying skin may also appear red and inflamed. Lymphadenitis can occur in any part of the body where there are lymph nodes, including the neck, armpits, groin, and abdomen.

The underlying cause of lymphadenitis must be diagnosed and treated promptly to prevent complications such as the spread of infection or the formation of an abscess. Treatment may include antibiotics, pain relievers, and warm compresses to help reduce swelling and discomfort.

Coccidiostats are a type of medication used to prevent and treat coccidiosis, which is an infection caused by protozoan parasites of the genus Coccidia. These medications work by inhibiting the growth and reproduction of the parasites in the gastrointestinal tract of animals, particularly poultry and livestock.

Coccidiostats are commonly added to animal feed to prevent infection and reduce the spread of coccidiosis within a flock or herd. They can also be used to treat active infections, often in combination with other medications. Common examples of coccidiostats include sulfaquinoxaline, monensin, and lasalocid.

It's important to note that the use of coccidiostats in food-producing animals is regulated by government agencies such as the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) to ensure their safe use and to minimize the risk of residues in animal products.

Infectious pregnancy complications refer to infections that occur during pregnancy and can affect the mother, fetus, or both. These infections can lead to serious consequences such as preterm labor, low birth weight, birth defects, stillbirth, or even death. Some common infectious agents that can cause pregnancy complications include:

1. Bacteria: Examples include group B streptococcus, Escherichia coli, and Listeria monocytogenes, which can cause sepsis, meningitis, or pneumonia in the mother and lead to preterm labor or stillbirth.
2. Viruses: Examples include cytomegalovirus, rubella, varicella-zoster, and HIV, which can cause congenital anomalies, developmental delays, or transmission of the virus to the fetus.
3. Parasites: Examples include Toxoplasma gondii, which can cause severe neurological damage in the fetus if transmitted during pregnancy.
4. Fungi: Examples include Candida albicans, which can cause fungal infections in the mother and lead to preterm labor or stillbirth.

Preventive measures such as vaccination, good hygiene practices, and avoiding high-risk behaviors can help reduce the risk of infectious pregnancy complications. Prompt diagnosis and treatment of infections during pregnancy are also crucial to prevent adverse outcomes.

Vertical transmission of infectious diseases refers to the spread of an infection from an infected mother to her offspring during pregnancy, childbirth, or breastfeeding. This mode of transmission can occur through several pathways:

1. Transplacental transmission: The infection crosses the placenta and reaches the fetus while it is still in the womb. Examples include HIV, syphilis, and toxoplasmosis.
2. Intrauterine infection: The mother's infection causes direct damage to the developing fetus or its surrounding tissues, leading to complications such as congenital defects. Examples include rubella and cytomegalovirus (CMV).
3. Perinatal transmission: This occurs during childbirth when the infant comes into contact with the mother's infected genital tract or bodily fluids. Examples include group B streptococcus, herpes simplex virus (HSV), and hepatitis B.
4. Postnatal transmission: This occurs after birth, often through breastfeeding, when the infant ingests infected milk or comes into contact with the mother's contaminated bodily fluids. Examples include HIV and HTLV-I (human T-lymphotropic virus type I).

Vertical transmission is a significant concern in public health, as it can lead to severe complications, congenital disabilities, or even death in newborns. Preventive measures, such as prenatal screening, vaccination, and antimicrobial treatment, are crucial for reducing the risk of vertical transmission and ensuring better outcomes for both mothers and their offspring.

Parasitic skin diseases are conditions caused by parasites living on or in the skin. These parasites can be insects, mites, or fungi that feed off of the host for their own survival. They can cause a variety of symptoms including itching, rashes, blisters, and lesions on the skin. Examples of parasitic skin diseases include scabies, lice infestations, and ringworm. Treatment typically involves the use of topical or oral medications to kill the parasites and alleviate symptoms.

Sensitivity and specificity are statistical measures used to describe the performance of a diagnostic test or screening tool in identifying true positive and true negative results.

* Sensitivity refers to the proportion of people who have a particular condition (true positives) who are correctly identified by the test. It is also known as the "true positive rate" or "recall." A highly sensitive test will identify most or all of the people with the condition, but may also produce more false positives.
* Specificity refers to the proportion of people who do not have a particular condition (true negatives) who are correctly identified by the test. It is also known as the "true negative rate." A highly specific test will identify most or all of the people without the condition, but may also produce more false negatives.

In medical testing, both sensitivity and specificity are important considerations when evaluating a diagnostic test. High sensitivity is desirable for screening tests that aim to identify as many cases of a condition as possible, while high specificity is desirable for confirmatory tests that aim to rule out the condition in people who do not have it.

It's worth noting that sensitivity and specificity are often influenced by factors such as the prevalence of the condition in the population being tested, the threshold used to define a positive result, and the reliability and validity of the test itself. Therefore, it's important to consider these factors when interpreting the results of a diagnostic test.

An immunocompromised host refers to an individual who has a weakened or impaired immune system, making them more susceptible to infections and decreased ability to fight off pathogens. This condition can be congenital (present at birth) or acquired (developed during one's lifetime).

Acquired immunocompromised states may result from various factors such as medical treatments (e.g., chemotherapy, radiation therapy, immunosuppressive drugs), infections (e.g., HIV/AIDS), chronic diseases (e.g., diabetes, malnutrition, liver disease), or aging.

Immunocompromised hosts are at a higher risk for developing severe and life-threatening infections due to their reduced immune response. Therefore, they require special consideration when it comes to prevention, diagnosis, and treatment of infectious diseases.

Immunoglobulin A (IgA) is a type of antibody that plays a crucial role in the immune function of the human body. It is primarily found in external secretions, such as saliva, tears, breast milk, and sweat, as well as in mucous membranes lining the respiratory and gastrointestinal tracts. IgA exists in two forms: a monomeric form found in serum and a polymeric form found in secretions.

The primary function of IgA is to provide immune protection at mucosal surfaces, which are exposed to various environmental antigens, such as bacteria, viruses, parasites, and allergens. By doing so, it helps prevent the entry and colonization of pathogens into the body, reducing the risk of infections and inflammation.

IgA functions by binding to antigens present on the surface of pathogens or allergens, forming immune complexes that can neutralize their activity. These complexes are then transported across the epithelial cells lining mucosal surfaces and released into the lumen, where they prevent the adherence and invasion of pathogens.

In summary, Immunoglobulin A (IgA) is a vital antibody that provides immune defense at mucosal surfaces by neutralizing and preventing the entry of harmful antigens into the body.

Polymerase Chain Reaction (PCR) is a laboratory technique used to amplify specific regions of DNA. It enables the production of thousands to millions of copies of a particular DNA sequence in a rapid and efficient manner, making it an essential tool in various fields such as molecular biology, medical diagnostics, forensic science, and research.

The PCR process involves repeated cycles of heating and cooling to separate the DNA strands, allow primers (short sequences of single-stranded DNA) to attach to the target regions, and extend these primers using an enzyme called Taq polymerase, resulting in the exponential amplification of the desired DNA segment.

In a medical context, PCR is often used for detecting and quantifying specific pathogens (viruses, bacteria, fungi, or parasites) in clinical samples, identifying genetic mutations or polymorphisms associated with diseases, monitoring disease progression, and evaluating treatment effectiveness.

A fatal outcome is a term used in medical context to describe a situation where a disease, injury, or illness results in the death of an individual. It is the most severe and unfortunate possible outcome of any medical condition, and is often used as a measure of the severity and prognosis of various diseases and injuries. In clinical trials and research, fatal outcome may be used as an endpoint to evaluate the effectiveness and safety of different treatments or interventions.

Naphthoquinones are a type of organic compound that consists of a naphthalene ring (two benzene rings fused together) with two ketone functional groups (=O) at the 1 and 2 positions. They exist in several forms, including natural and synthetic compounds. Some well-known naphthoquinones include vitamin K1 (phylloquinone) and K2 (menaquinone), which are important for blood clotting and bone metabolism. Other naphthoquinones have been studied for their potential medicinal properties, including anticancer, antibacterial, and anti-inflammatory activities. However, some naphthoquinones can also be toxic or harmful to living organisms, so they must be used with caution.

Encephalitis is defined as inflammation of the brain parenchyma, which is often caused by viral infections but can also be due to bacterial, fungal, or parasitic infections, autoimmune disorders, or exposure to toxins. The infection or inflammation can cause various symptoms such as headache, fever, confusion, seizures, and altered consciousness, ranging from mild symptoms to severe cases that can lead to brain damage, long-term disabilities, or even death.

The diagnosis of encephalitis typically involves a combination of clinical evaluation, imaging studies (such as MRI or CT scans), and laboratory tests (such as cerebrospinal fluid analysis). Treatment may include antiviral medications, corticosteroids, immunoglobulins, and supportive care to manage symptoms and prevent complications.

Food parasitology is not a commonly used term in medical or scientific communities. However, it generally refers to the study of parasites that are transmitted through food, including parasitic protozoa, helminths (worms), and arthropods (e.g., tapeworms, roundworms, Giardia, Cryptosporidium, etc.). Food parasitology involves understanding the life cycles, epidemiology, diagnosis, treatment, and prevention of these foodborne parasites. It is an important field within medical and veterinary parasitology, as well as food safety and public health.

Agglutination tests are laboratory diagnostic procedures used to detect the presence of antibodies or antigens in a sample, such as blood or serum. These tests work by observing the clumping (agglutination) of particles, like red blood cells or bacteriophages, coated with specific antigens or antibodies when mixed with a patient's sample.

In an agglutination test, the sample is typically combined with a reagent containing known antigens or antibodies on the surface of particles, such as latex beads, red blood cells, or bacteriophages. If the sample contains the corresponding antibodies or antigens, they will bind to the particles, forming visible clumps or agglutinates. The presence and strength of agglutination are then assessed visually or with automated equipment to determine the presence and quantity of the target antigen or antibody in the sample.

Agglutination tests are widely used in medical diagnostics for various applications, including:

1. Bacterial and viral infections: To identify specific bacterial or viral antigens in a patient's sample, such as group A Streptococcus, Legionella pneumophila, or HIV.
2. Blood typing: To determine the ABO blood group and Rh type of a donor or recipient before a blood transfusion or organ transplantation.
3. Autoimmune diseases: To detect autoantibodies in patients with suspected autoimmune disorders, such as rheumatoid arthritis, systemic lupus erythematosus, or Hashimoto's thyroiditis.
4. Allergies: To identify specific IgE antibodies in a patient's sample to determine allergic reactions to various substances, such as pollen, food, or venom.
5. Drug monitoring: To detect and quantify the presence of drug-induced antibodies, such as those developed in response to penicillin or hydralazine therapy.

Agglutination tests are simple, rapid, and cost-effective diagnostic tools that provide valuable information for clinical decision-making and patient management. However, they may have limitations, including potential cross-reactivity with other antigens, false-positive results due to rheumatoid factors or heterophile antibodies, and false-negative results due to the prozone effect or insufficient sensitivity. Therefore, it is essential to interpret agglutination test results in conjunction with clinical findings and other laboratory data.

Clindamycin is a antibiotic medication used to treat a variety of bacterial infections. It is a type of antibiotic known as a lincosamide, which works by binding to the bacterial ribosome and inhibiting protein synthesis. This leads to the death of the bacteria and helps to clear the infection.

Clindamycin is effective against a wide range of gram-positive and some anaerobic bacteria, making it a useful antibiotic for treating many different types of infections, including skin and soft tissue infections, bone and joint infections, respiratory infections, and dental infections. It is also sometimes used to treat certain types of bacterial vaginal infections.

Like all antibiotics, clindamycin should be used only under the direction of a healthcare provider, as misuse can lead to antibiotic resistance. Additionally, clindamycin can cause side effects such as diarrhea, nausea, and vomiting, and it may increase the risk of developing a serious intestinal infection called Clostridioides difficile-associated diarrhea (CDAD). It is important to follow your healthcare provider's instructions carefully when taking this medication.

There are many diseases that can affect cats, and the specific medical definitions for these conditions can be quite detailed and complex. However, here are some common categories of feline diseases and examples of each:

1. Infectious diseases: These are caused by viruses, bacteria, fungi, or parasites. Examples include:
* Feline panleukopenia virus (FPV), also known as feline parvovirus, which can cause severe gastrointestinal symptoms and death in kittens.
* Feline calicivirus (FCV), which can cause upper respiratory symptoms such as sneezing and nasal discharge.
* Feline leukemia virus (FeLV), which can suppress the immune system and lead to a variety of secondary infections and diseases.
* Bacterial infections, such as those caused by Pasteurella multocida or Bartonella henselae, which can cause abscesses or other symptoms.
2. Neoplastic diseases: These are cancerous conditions that can affect various organs and tissues in cats. Examples include:
* Lymphoma, which is a common type of cancer in cats that can affect the lymph nodes, spleen, liver, and other organs.
* Fibrosarcoma, which is a type of soft tissue cancer that can arise from fibrous connective tissue.
* Squamous cell carcinoma, which is a type of skin cancer that can be caused by exposure to sunlight or tobacco smoke.
3. Degenerative diseases: These are conditions that result from the normal wear and tear of aging or other factors. Examples include:
* Osteoarthritis, which is a degenerative joint disease that can cause pain and stiffness in older cats.
* Dental disease, which is a common condition in cats that can lead to tooth loss, gum inflammation, and other problems.
* Heart disease, such as hypertrophic cardiomyopathy (HCM), which is a thickening of the heart muscle that can lead to congestive heart failure.
4. Hereditary diseases: These are conditions that are inherited from a cat's parents and are present at birth or develop early in life. Examples include:
* Polycystic kidney disease (PKD), which is a genetic disorder that causes cysts to form in the kidneys and can lead to kidney failure.
* Hypertrophic cardiomyopathy (HCM), which can be inherited as an autosomal dominant trait in some cats.
* Progressive retinal atrophy (PRA), which is a group of genetic disorders that cause degeneration of the retina and can lead to blindness.

Prenatal diagnosis is the medical testing of fetuses, embryos, or pregnant women to detect the presence or absence of certain genetic disorders or birth defects. These tests can be performed through various methods such as chorionic villus sampling (CVS), amniocentesis, or ultrasound. The goal of prenatal diagnosis is to provide early information about the health of the fetus so that parents and healthcare providers can make informed decisions about pregnancy management and newborn care. It allows for early intervention, treatment, or planning for the child's needs after birth.

I'm sorry for any confusion, but "Suriname" is not a medical term. It is a country located in South America, known for its diverse culture and rich biodiversity. If you have any questions about medical terminology or Surinamese health issues, I would be happy to try to help answer those!

Immunocompetence is the condition of having a properly functioning immune system that can effectively respond to the presence of foreign substances, such as pathogens (like bacteria, viruses, and parasites) and other potentially harmful agents. It involves the ability of the immune system to recognize, attack, and eliminate these foreign substances while also maintaining tolerance to self-tissues and promoting tissue repair.

Immunocompetence is essential for overall health and wellbeing, as it helps protect the body from infections and diseases. Factors that can affect immunocompetence include age, genetics, stress, nutrition, sleep, and certain medical conditions or treatments (like chemotherapy or immunosuppressive drugs) that can weaken the immune system.

Uveitis is the inflammation of the uvea, the middle layer of the eye between the retina and the white of the eye (sclera). The uvea consists of the iris, ciliary body, and choroid. Uveitis can cause redness, pain, and vision loss. It can be caused by various systemic diseases, infections, or trauma. Depending on the part of the uvea that's affected, uveitis can be classified as anterior (iritis), intermediate (cyclitis), posterior (choroiditis), or pan-uveitis (affecting all layers). Treatment typically includes corticosteroids and other immunosuppressive drugs to control inflammation.

An oocyst is a thick-walled, environmentally resistant spore-like structure produced by some protozoan parasites, such as Cryptosporidium and Cyclospora, during their life cycle. These oocysts can survive for long periods in the environment and can infect a host when ingested, leading to infection and disease. The term "oocyst" is specific to certain groups of protozoan parasites and should not be confused with other types of spores produced by fungi or bacteria.

The HLA-B15 antigen is a human leukocyte antigen (HLA) type B serotype that is encoded by the HLA-B gene located on chromosome 6 in humans. The HLA system plays an essential role in the immune system, presenting foreign peptides to T-cells and triggering an immune response.

The HLA-B15 antigen is a type of class I major histocompatibility complex (MHC) protein, which presents endogenous peptides to CD8+ cytotoxic T lymphocytes (CTLs). The HLA-B15 serotype includes several subtypes, such as HLA-B*1501, HLA-B*1502, and others.

The HLA-B15 antigen is associated with certain diseases, including an increased risk of developing Behçet's disease, a rare autoimmune disorder that causes inflammation in various parts of the body. Additionally, the HLA-B*1502 subtype has been found to be strongly associated with carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) in individuals of Asian descent.

An aborted fetus refers to a developing human organism that is expelled or removed from the uterus before it is viable, typically as a result of an induced abortion. An abortion is a medical procedure that intentionally ends a pregnancy and can be performed through various methods, depending on the stage of the pregnancy.

It's important to note that the term "abortion" is often used in different contexts and may carry different connotations depending on one's perspective. In medical terminology, an abortion refers specifically to the intentional ending of a pregnancy before viability. However, in other contexts, the term may be used more broadly to refer to any spontaneous or induced loss of a pregnancy, including miscarriages and stillbirths.

The definition of "viable" can vary, but it generally refers to the point at which a fetus can survive outside the uterus with medical assistance, typically around 24 weeks of gestation. Fetal viability is a complex issue that depends on many factors, including the availability and accessibility of medical technology and resources.

In summary, an aborted fetus is a developing human organism that is intentionally expelled or removed from the uterus before it is viable, typically as a result of a medical procedure called an abortion.

I'm sorry for any confusion, but "Kyrgyzstan" is not a medical term. It is the name of a country located in Central Asia. If you have any questions about medical terms or concepts, I would be happy to help clarify those for you.

Amniotic fluid is a clear, slightly yellowish liquid that surrounds and protects the developing baby in the uterus. It is enclosed within the amniotic sac, which is a thin-walled sac that forms around the embryo during early pregnancy. The fluid is composed of fetal urine, lung secretions, and fluids that cross over from the mother's bloodstream through the placenta.

Amniotic fluid plays several important roles in pregnancy:

1. It provides a shock-absorbing cushion for the developing baby, protecting it from injury caused by movement or external forces.
2. It helps to maintain a constant temperature around the fetus, keeping it warm and comfortable.
3. It allows the developing baby to move freely within the uterus, promoting normal growth and development of the muscles and bones.
4. It provides a source of nutrients and hydration for the fetus, helping to support its growth and development.
5. It helps to prevent infection by providing a barrier between the fetus and the outside world.

Throughout pregnancy, the volume of amniotic fluid increases as the fetus grows. The amount of fluid typically peaks around 34-36 weeks of gestation, after which it begins to gradually decrease. Abnormalities in the volume of amniotic fluid can indicate problems with the developing baby or the pregnancy itself, and may require medical intervention.

'Trichechus manatus' is the scientific name for the West Indian Manatee, also known as the American Manatee. It is a large, aquatic, herbivorous mammal that lives in warm, shallow waters of the Caribbean Sea, Gulf of Mexico, and Atlantic Ocean along the North American coast. They are known for their slow movement, wrinkled skin, and paddle-like flippers. West Indian Manatees are an endangered species due to habitat loss, boat strikes, and other human activities.

"Cat" is a common name that refers to various species of small carnivorous mammals that belong to the family Felidae. The domestic cat, also known as Felis catus or Felis silvestris catus, is a popular pet and companion animal. It is a subspecies of the wildcat, which is found in Europe, Africa, and Asia.

Domestic cats are often kept as pets because of their companionship, playful behavior, and ability to hunt vermin. They are also valued for their ability to provide emotional support and therapy to people. Cats are obligate carnivores, which means that they require a diet that consists mainly of meat to meet their nutritional needs.

Cats are known for their agility, sharp senses, and predatory instincts. They have retractable claws, which they use for hunting and self-defense. Cats also have a keen sense of smell, hearing, and vision, which allow them to detect prey and navigate their environment.

In medical terms, cats can be hosts to various parasites and diseases that can affect humans and other animals. Some common feline diseases include rabies, feline leukemia virus (FeLV), feline immunodeficiency virus (FIV), and toxoplasmosis. It is important for cat owners to keep their pets healthy and up-to-date on vaccinations and preventative treatments to protect both the cats and their human companions.

Opportunistic infections (OIs) are infections that occur more frequently or are more severe in individuals with weakened immune systems, often due to a underlying condition such as HIV/AIDS, cancer, or organ transplantation. These infections are caused by microorganisms that do not normally cause disease in people with healthy immune function, but can take advantage of an opportunity to infect and cause damage when the body's defense mechanisms are compromised. Examples of opportunistic infections include Pneumocystis pneumonia, tuberculosis, candidiasis (thrush), and cytomegalovirus infection. Preventive measures, such as antimicrobial medications and vaccinations, play a crucial role in reducing the risk of opportunistic infections in individuals with weakened immune systems.

Aqueous humor is a clear, watery fluid that fills the anterior and posterior chambers of the eye. It is produced by the ciliary processes in the posterior chamber and circulates through the pupil into the anterior chamber, where it provides nutrients to the cornea and lens, maintains intraocular pressure, and helps to shape the eye. The aqueous humor then drains out of the eye through the trabecular meshwork and into the canal of Schlemm, eventually reaching the venous system.

Hemagglutination tests are laboratory procedures used to detect the presence of antibodies or antigens in a sample, typically in blood serum. These tests rely on the ability of certain substances, such as viruses or bacteria, to agglutinate (clump together) red blood cells.

In a hemagglutination test, a small amount of the patient's serum is mixed with a known quantity of red blood cells that have been treated with a specific antigen. If the patient has antibodies against that antigen in their serum, they will bind to the antigens on the red blood cells and cause them to agglutinate. This clumping can be observed visually, indicating a positive test result.

Hemagglutination tests are commonly used to diagnose infectious diseases caused by viruses or bacteria that have hemagglutinating properties, such as influenza, parainfluenza, and HIV. They can also be used in blood typing and cross-matching before transfusions.

An immunoassay is a biochemical test that measures the presence or concentration of a specific protein, antibody, or antigen in a sample using the principles of antibody-antigen reactions. It is commonly used in clinical laboratories to diagnose and monitor various medical conditions such as infections, hormonal disorders, allergies, and cancer.

Immunoassays typically involve the use of labeled reagents, such as enzymes, radioisotopes, or fluorescent dyes, that bind specifically to the target molecule. The amount of label detected is proportional to the concentration of the target molecule in the sample, allowing for quantitative analysis.

There are several types of immunoassays, including enzyme-linked immunosorbent assay (ELISA), radioimmunoassay (RIA), fluorescence immunoassay (FIA), and chemiluminescent immunoassay (CLIA). Each type has its own advantages and limitations, depending on the sensitivity, specificity, and throughput required for a particular application.

Parasite load, in medical terms, refers to the total number or quantity of parasites (such as worms, protozoa, or other infectious agents) present in a host organism's body. It is often used to describe the severity of a parasitic infection and can be an important factor in determining the prognosis and treatment plan for the infected individual.

Parasite load can vary widely depending on the type of parasite, the route of infection, the immune status of the host, and other factors. In some cases, even a small number of parasites may cause significant harm if they are highly virulent or located in critical areas of the body. In other cases, large numbers of parasites may be necessary to produce noticeable symptoms.

Measuring parasite load can be challenging, as it often requires specialized laboratory techniques and equipment. However, accurate assessment of parasite load is important for both research and clinical purposes, as it can help researchers develop more effective treatments and allow healthcare providers to monitor the progression of an infection and evaluate the effectiveness of treatment.

Apicomplexa is a phylum of single-celled, parasitic organisms that includes several medically important genera, such as Plasmodium (which causes malaria), Toxoplasma (which causes toxoplasmosis), and Cryptosporidium (which causes cryptosporidiosis). These organisms are characterized by the presence of a unique apical complex, which is a group of specialized structures at one end of the cell that are used during invasion and infection of host cells. They have a complex life cycle involving multiple stages, including sexual and asexual reproduction, often in different hosts. Many Apicomplexa are intracellular parasites, meaning they live and multiply inside the cells of their hosts.

Host-parasite interactions refer to the relationship between a parasitic organism (the parasite) and its host, which can be an animal, plant, or human body. The parasite lives on or inside the host and derives nutrients from it, often causing harm in the process. This interaction can range from relatively benign to severe, depending on various factors such as the species of the parasite, the immune response of the host, and the duration of infection.

The host-parasite relationship is often categorized based on the degree of harm caused to the host. Parasites that cause little to no harm are called commensals, while those that cause significant damage or disease are called parasitic pathogens. Some parasites can even manipulate their hosts' behavior and physiology to enhance their own survival and reproduction, leading to complex interactions between the two organisms.

Understanding host-parasite interactions is crucial for developing effective strategies to prevent and treat parasitic infections, as well as for understanding the ecological relationships between different species in natural ecosystems.

I. Definition:

An abortion in a veterinary context refers to the intentional or unintentional termination of pregnancy in a non-human animal before the fetus is capable of surviving outside of the uterus. This can occur spontaneously (known as a miscarriage) or be induced through medical intervention (induced abortion).

II. Common Causes:

Spontaneous abortions may result from genetic defects, hormonal imbalances, infections, exposure to toxins, trauma, or other maternal health issues. Induced abortions are typically performed for population control, humane reasons (such as preventing the birth of a severely deformed or non-viable fetus), or when the pregnancy poses a risk to the mother's health.

III. Methods:

Veterinarians may use various methods to induce abortion depending on the species, stage of gestation, and reason for the procedure. These can include administering drugs that stimulate uterine contractions (such as prostaglandins), physically removing the fetus through surgery (dilation and curettage or hysterectomy), or using techniques specific to certain animal species (e.g., intrauterine infusion of hypertonic saline in equids).

IV. Ethical Considerations:

The ethics surrounding veterinary abortions are complex and multifaceted, often involving considerations related to animal welfare, conservation, population management, and human-animal relationships. Veterinarians must weigh these factors carefully when deciding whether to perform an abortion and which method to use. In some cases, legal regulations may also influence the decision-making process.

V. Conclusion:

Abortion in veterinary medicine is a medical intervention that can be used to address various clinical scenarios, ranging from unintentional pregnancy loss to deliberate termination of pregnancy for humane or population control reasons. Ethical considerations play a significant role in the decision-making process surrounding veterinary abortions, and veterinarians must carefully evaluate each situation on a case-by-case basis.

Central nervous system (CNS) protozoal infections refer to diseases caused by protozoa that invade and infect the brain and spinal cord. These infections can lead to serious neurological symptoms and complications.

There are several types of protozoa that can cause CNS infections, including:

1. Toxoplasma gondii: This parasite is commonly found in cats and can be transmitted to humans through contact with infected cat feces or consumption of undercooked meat. In people with weakened immune systems, T. gondii can cause severe CNS symptoms such as seizures, confusion, and coma.
2. Naegleria fowleri: Also known as the "brain-eating amoeba," N. fowleri is a free-living protozoan found in warm freshwater environments. When people swim or dive in infected water, the amoeba can enter the body through the nose and travel to the brain, causing primary amoebic meningoencephalitis (PAM), a rare but often fatal CNS infection.
3. Acanthamoeba: Like N. fowleri, Acanthamoeba is a free-living protozoan found in freshwater and soil. It can cause a range of CNS infections, including granulomatous amoebic encephalitis (GAE), which typically affects people with weakened immune systems.
4. Trypanosoma brucei: This parasite is transmitted through the bite of infected tsetse flies and causes African sleeping sickness, a CNS infection that can lead to coma and death if left untreated.
5. Plasmodium falciparum: While not strictly a protozoan, P. falciparum is a parasite that causes malaria, a mosquito-borne disease that can cause severe CNS symptoms such as seizures, coma, and cerebral malaria.

Treatment for CNS protozoal infections depends on the specific type of infection and may include antiprotozoal medications, antibiotics, or supportive care to manage symptoms. Prevention measures include avoiding contact with infected animals or insects, practicing good hygiene, and using appropriate protective measures such as insect repellent or bed nets in areas where these infections are common.

Eye diseases are a range of conditions that affect the eye or visual system, causing damage to vision and, in some cases, leading to blindness. These diseases can be categorized into various types, including:

1. Refractive errors: These include myopia (nearsightedness), hyperopia (farsightedness), astigmatism, and presbyopia, which affect the way light is focused on the retina and can usually be corrected with glasses or contact lenses.
2. Cataracts: A clouding of the lens inside the eye that leads to blurry vision, glare, and decreased contrast sensitivity. Cataract surgery is the most common treatment for this condition.
3. Glaucoma: A group of diseases characterized by increased pressure in the eye, leading to damage to the optic nerve and potential blindness if left untreated. Treatment includes medications, laser therapy, or surgery.
4. Age-related macular degeneration (AMD): A progressive condition that affects the central part of the retina called the macula, causing blurry vision and, in advanced stages, loss of central vision. Treatment may include anti-VEGF injections, laser therapy, or nutritional supplements.
5. Diabetic retinopathy: A complication of diabetes that affects the blood vessels in the retina, leading to bleeding, leakage, and potential blindness if left untreated. Treatment includes laser therapy, anti-VEGF injections, or surgery.
6. Retinal detachment: A separation of the retina from its underlying tissue, which can lead to vision loss if not treated promptly with surgery.
7. Amblyopia (lazy eye): A condition where one eye does not develop normal vision, often due to a misalignment or refractive error in childhood. Treatment includes correcting the underlying problem and encouraging the use of the weaker eye through patching or other methods.
8. Strabismus (crossed eyes): A misalignment of the eyes that can lead to amblyopia if not treated promptly with surgery, glasses, or other methods.
9. Corneal diseases: Conditions that affect the transparent outer layer of the eye, such as keratoconus, Fuchs' dystrophy, and infectious keratitis, which can lead to vision loss if not treated promptly.
10. Uveitis: Inflammation of the middle layer of the eye, which can cause vision loss if not treated promptly with anti-inflammatory medications or surgery.

Retinitis is a medical term that refers to the inflammation of the retina, which is the light-sensitive tissue located at the back of the eye. The retina is responsible for converting light into electrical signals that are then sent to the brain and interpreted as visual images. Retinitis can be caused by various factors, including infections, autoimmune diseases, or genetic conditions.

The inflammation associated with retinitis can affect any part of the retina, but it typically involves the retinal pigment epithelium (RPE) and the photoreceptor cells (rods and cones). Depending on the severity and location of the inflammation, retinitis can cause a range of visual symptoms, such as blurry vision, floaters, loss of peripheral vision, or night blindness.

Retinitis is often distinguished from another condition called retinopathy, which refers to damage to the retina caused by diabetes or other systemic diseases. While both conditions can affect the retina and cause visual symptoms, retinitis is characterized by inflammation, while retinopathy is characterized by damage due to circulatory problems.

It's important to note that retinitis is a serious condition that requires prompt medical attention. If left untreated, it can lead to permanent vision loss or blindness. Treatment options for retinitis depend on the underlying cause and may include antibiotics, corticosteroids, or other immunosuppressive medications.

Domestic animals, also known as domestic animals or pets, are species that have been tamed and kept by humans for various purposes. These purposes can include companionship, work, protection, or food production. Some common examples of domestic animals include dogs, cats, cows, sheep, goats, pigs, horses, and chickens.

Domestic animals are distinguished from wild animals in that they are dependent on humans for their survival and are able to live in close proximity to people. They have often been selectively bred over generations to possess certain traits or characteristics that make them more suitable for their intended uses. For example, dogs may be bred for their size, strength, agility, or temperament, while cats may be bred for their coat patterns or behaviors.

It is important to note that the term "domestic animal" does not necessarily mean that an animal is tame or safe to handle. Some domestic animals, such as certain breeds of dogs, can be aggressive or dangerous if not properly trained and managed. It is always important to approach and handle any animal, domestic or wild, with caution and respect.

Clinical laboratory techniques are methods and procedures used in medical laboratories to perform various tests and examinations on patient samples. These techniques help in the diagnosis, treatment, and prevention of diseases by analyzing body fluids, tissues, and other specimens. Some common clinical laboratory techniques include:

1. Clinical chemistry: It involves the analysis of bodily fluids such as blood, urine, and cerebrospinal fluid to measure the levels of chemicals, hormones, enzymes, and other substances in the body. These measurements can help diagnose various medical conditions, monitor treatment progress, and assess overall health.

2. Hematology: This technique focuses on the study of blood and its components, including red and white blood cells, platelets, and clotting factors. Hematological tests are used to diagnose anemia, infections, bleeding disorders, and other hematologic conditions.

3. Microbiology: It deals with the identification and culture of microorganisms such as bacteria, viruses, fungi, and parasites. Microbiological techniques are essential for detecting infectious diseases, determining appropriate antibiotic therapy, and monitoring the effectiveness of treatment.

4. Immunology: This technique involves studying the immune system and its response to various antigens, such as bacteria, viruses, and allergens. Immunological tests are used to diagnose autoimmune disorders, immunodeficiencies, and allergies.

5. Histopathology: It is the microscopic examination of tissue samples to identify any abnormalities or diseases. Histopathological techniques are crucial for diagnosing cancer, inflammatory conditions, and other tissue-related disorders.

6. Molecular biology: This technique deals with the study of DNA, RNA, and proteins at the molecular level. Molecular biology tests can be used to detect genetic mutations, identify infectious agents, and monitor disease progression.

7. Cytogenetics: It involves analyzing chromosomes and genes in cells to diagnose genetic disorders, cancer, and other diseases. Cytogenetic techniques include karyotyping, fluorescence in situ hybridization (FISH), and comparative genomic hybridization (CGH).

8. Flow cytometry: This technique measures physical and chemical characteristics of cells or particles as they flow through a laser beam. Flow cytometry is used to analyze cell populations, identify specific cell types, and detect abnormalities in cells.

9. Diagnostic radiology: It uses imaging technologies such as X-rays, computed tomography (CT), magnetic resonance imaging (MRI), and ultrasound to diagnose various medical conditions.

10. Clinical chemistry: This technique involves analyzing body fluids, such as blood and urine, to measure the concentration of various chemicals and substances. Clinical chemistry tests are used to diagnose metabolic disorders, electrolyte imbalances, and other health conditions.

Fetal diseases are medical conditions or abnormalities that affect a fetus during pregnancy. These diseases can be caused by genetic factors, environmental influences, or a combination of both. They can range from mild to severe and may impact various organ systems in the developing fetus. Examples of fetal diseases include congenital heart defects, neural tube defects, chromosomal abnormalities such as Down syndrome, and infectious diseases such as toxoplasmosis or rubella. Fetal diseases can be diagnosed through prenatal testing, including ultrasound, amniocentesis, and chorionic villus sampling. Treatment options may include medication, surgery, or delivery of the fetus, depending on the nature and severity of the disease.

Protozoan infections are diseases caused by microscopic, single-celled organisms known as protozoa. These parasites can enter the human body through contaminated food, water, or contact with an infected person or animal. Once inside the body, they can multiply and cause a range of symptoms depending on the type of protozoan and where it infects in the body. Some common protozoan infections include malaria, giardiasis, amoebiasis, and toxoplasmosis. Symptoms can vary widely but may include diarrhea, abdominal pain, fever, fatigue, and skin rashes. Treatment typically involves the use of antiprotozoal medications to kill the parasites and alleviate symptoms.

Congenital toxoplasmosis is a specific form of toxoplasmosis in which an unborn fetus is infected via the placenta. Congenital ... "Congenital toxoplasmosis". American Family Physician. 67 (10): 2131-8. PMID 12776962. "Congenital toxoplasmosis: MedlinePlus ... Toxoplasmosis Study Group) (15 May 2006). "Outcome of Treatment for Congenital Toxoplasmosis, 1981-2004: The National ... a condition known as congenital toxoplasmosis may affect the child. Toxoplasmosis is usually spread by eating poorly cooked ...
Martin S (June 2001). "Congenital toxoplasmosis". Neonatal Network. 20 (4): 23-30. doi:10.1891/0730-0832.20.4.23. PMID 12143899 ... Amniocentesis can be used to detect other congenital infections such as cytomegalovirus, hepatitis B, parvovirus B19, and ... Tissues obtained from amniotic cell lines show significant promise for patients with congenital diseases/malformations of the ... Attwood LO, Holmes NE, Hui L (December 2020). "Identification and management of congenital parvovirus B19 infection". Prenatal ...
Bobić, B; Villena, I; Stillwaggon, E (September 2019). "Prevention and mitigation of congenital toxoplasmosis. Economic costs ... and commonly toxoplasmosis. Toxoplasmosis can be acquired through eating infected undercooked meat or contaminated food, and by ... Instead, toxic exposure often causes physiological abnormalities or minor congenital malformation. Development continues ...
She has a vision impairment called congenital toxoplasmosis. As a result of the condition, she only has peripheral vision since ...
In congenital toxoplasmosis, the disease is bilateral in 65-85% of cases and involves the macula in 58%. Chronic or recurrent ... IgA : Measurement of IgA antibody titers may also be useful in a diagnosis of congenital toxoplasmosis in a fetus or newborn ... Congenital toxoplasmosis may lead to hydrocephalus, seizures, lymphadenopathy, hepatosplenomegaly, rash, and fever. However, ... Congenital disease occurs due to the acquisition of the organism by a pregnant woman exposed to tissue cysts or oocytes in ...
There was no evidence of maternal transmission of antibodies or congenital toxoplasmosis. None of the infected macaques died ...
Others are: Toxoplasmosis, Rubella, and Herpes simplex.) Congenital HCMV infection occurs when the mother has a primary ... Congenital cytomegalovirus infection can lead to significant morbidity and even death. After infection, HCMV remains latent ... Congenital HCMV is the leading infectious cause of deafness, learning disabilities, and intellectual disability in children. ... In one case also congenital CMV was encountered. In 2013, Astellas Pharma started on individuals who received a hematopoietic ...
The illness admitted by Hanley was congenital cerebral toxoplasmosis, described as an "eye disorder"; he was blind in one eye ... Toxoplasmosis is very rarely fatal in adults who do not have a weakened immune system. In 2000, Hanley's friend and colleague ...
... global status of Toxoplasma gondii seroprevalence and implications for pregnancy and congenital toxoplasmosis". International ... "Toxoplasmosis-a global threat. Correlation of latent toxoplasmosis with specific disease burden in a set of 88 countries". PLOS ... Toxoplasmosis is becoming a global health hazard as it infects 30-50% of the world human population. Clinically, the life-long ... The seroprevalence of toxoplasmosis correlated with various disease burden. Statistical associations does not necessarily mean ...
Congenital toxoplasmosis, CMV or rubella may be seen on X-ray as calcifications in the brain. Dense scars may undergo hyaline ...
Due to the risk of congenital toxoplasmosis in the fetus, pregnant women are advised not to eat raw meat. Latent toxoplasmosis ... Congenital toxoplasmosis-further thought for food". BMJ. 321 (7254): 142-147. doi:10.1136/bmj.321.7254.142. PMC 27431. PMID ... Latent toxoplasmosis in adults has been thought to, but not proven to, cause psychological effects and lower IQ in some studies ... "Toxoplasmosis , ANSES - Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail". Anses.fr. ...
... human congenital toxoplasmosis. Fetus bearer of these alleles thus suffer an increased susceptibility to this disease. GRCh38: ... "ALOX12 in human toxoplasmosis". Infection and Immunity. 82 (7): 2670-9. doi:10.1128/IAI.01505-13. PMC 4097613. PMID 24686056. ...
Congenital rubella syndrome, Cytomegalovirus, and toxoplasmosis are known to cause deafness or more severe complications in ... Congenital disorders are defined as a set of conditions present at or before birth and can be caused by genetic make up ... Deafblindness is a condition that can be either congenital or acquired. 87% of deafblind children and youth have at least one ... "Congenital disorder - Deformities". Encyclopedia Britannica. Archived from the original on 2015-09-05. CDC (2020-12-30). "Data ...
Congenital toxoplasmosis via transplacental transmission can also lead to sequelae such as chorioretinitis along with ... Chorioretinitis is often caused by toxoplasmosis and cytomegalovirus infections (mostly seen in immunodeficient subjects such ...
Idiopathic List of congenital disorders List of ICD-9 codes 740-759: Congenital anomalies Malformative syndrome March of Dimes ... Mother exposure to toxoplasmosis can cause cerebral calcification, hydrocephalus (causes mental disabilities), and intellectual ... Birth defect is a widely used term for a congenital malformation, i.e. a congenital, physical anomaly that is recognizable at ... congenital aplasia or hypoplasia, amniotic band syndrome, and cleidocranial dysostosis. Congenital heart defects include patent ...
Babies with chromosomal abnormalities or other congenital anomalies may manifest IUGR as part of their syndrome. Problems with ... Infections during pregnancy that affect the fetus, such as rubella, cytomegalovirus, toxoplasmosis, and syphilis, may also ...
Horizontal disease transmission TORCH syndrome Congenital cytomegalovirus infection Congenital rubella syndrome Congenital ... Several vertically transmitted infections are included in the TORCH complex: T - toxoplasmosis from Toxoplasma gondii O - other ... The term congenital infection can be used if the vertically transmitted infection persists after childbirth.[citation needed] ... Ford-Jones, E. L.; Kellner, J. D. (1995). ""Cheap torches": An acronym for congenital and perinatal infections". The Pediatric ...
Protozoa like Plasmodium or Toxoplasma which can cause congenital toxoplasmosis with multiple cysts in the brain and other ... congenital rubella syndrome), Zika virus, or bacteria like Treponema pallidum in congenital syphilis, which may progress to ... Common causes of congenital injury are asphyxia (obstruction of the trachea), hypoxia (lack of oxygen to the brain), and the ... see also congenital iodine deficiency syndrome). Excesses in both maternal and infant diets may cause disorders as well, with ...
... is a cluster of symptoms caused by congenital infection with toxoplasmosis, rubella, cytomegalovirus, herpes ...
Congenital infections: syphilis, cytomegalovirus, toxoplasmosis, rubella, human immunodeficiency virus (HIV), malaria, ... Congenital nephrotic syndrome 1 at NIH's Office of Rare Diseases OMIM: 609049 Pierson syndrome; Microcoria and congenital ... Congenital nephrotic syndrome is a rare kidney disease which manifests in infants during the first 3 months of life, and is ... Congenital nephrotic syndrome can be successfully controlled with early diagnosis and aggressive treatment including albumin ...
He was born with congenital toxoplasmosis which resulted in his vision gradually failing until stabilising at the age of 13 ...
4: Toxoplasmosis and Babesiosis in Asia; Edit-in-chief: Yano A; Vol Edit: Yano A, Nam H-W, Anuar A K, Shen J, Saito A & ... Congenital Infection. In: Current Trends in Pediatrics. Vol. 3; Edit: Mathur GP & Mathur S. Academa Publishers, Delhi, India ...
Premature Birth Refractive error Congenital cataract Retinopathy of prematurity Infection Congenital toxoplasmosis Congenital ... Congenital blindness refers to blindness present at birth. Congenital blindness is sometimes used interchangeably with " ... There are multiple possible causes of congenital blindness. In general, 60% of congenital blindness cases are contributed from ... Leber congenital amaurosis (LCA) has been a major focus in the development of gene therapy for treatment of the disease, as it ...
The fetus of a pregnant woman who has Zika fever may die or be born with congenital central nervous system malformations, like ... toxoplasmosis, rubella, cytomegalovirus infection, lymphocytic choriomeningitis virus infection, and herpes simplex virus. Some ... For infants with suspected congenital Zika virus disease, the CDC recommends testing with both serologic and molecular assays ... Testing should be done for any abnormalities encountered as well as for other congenital infections such as syphilis, ...
"The genetics of congenital myopathies". Handbook of Clinical Neurology. 148: 549-564. doi:10.1016/B978-0-444-64076-5.00036-3. ... dystrophy Becker's muscular dystrophy Myotubular myopathy Centronuclear myopathy Electromyogram Trichinosis Toxoplasmosis ... "Congenital myopathies: disorders of excitation-contraction coupling and muscle contraction". Nature Reviews Neurology. 14 (3): ...
Vertically transmitted infections Congenital cytomegalovirus infection Toxoplasmosis Congenital rubella syndrome Congenital ... "Congenital Disorders of Glycosylation". NORD (National Organization for Rare Disorders). Retrieved 2019-08-01. "Mito Info". ... The spread of Aedes mosquito-borne Zika virus has been implicated in increasing levels of congenital microcephaly by the ... Leviton, A.; Holmes, L.B.; Allred, E.N.; Vargas, J. (2002). "Methodologic issues in epidemiologic studies of congenital ...
Toxic conjunctivitis Toxic shock syndrome Toxocariasis Toxopachyoteose diaphysaire tibio peroniere Toxoplasmosis Toxoplasmosis ... congenital Tracheal agenesis Tracheobronchomalacia Tracheobronchomegaly Tracheobronchopathia osteoplastica Tracheoesophageal ... Thrombocytopenia cerebellar hypoplasia short stature Thrombocytopenia chromosome breakage Thrombocytopenia multiple congenital ...
... and has the potential to cause congenital toxoplasmosis in the fetus, which has many associated birth complications. Testing ... as CMV is the most common congenital infection and is associated with congenital hearing loss, major handicaps, and death in ... "Cytomegalovirus, Parvovirus B19, Varicella Zoster, and Toxoplasmosis in Pregnancy". www.acog.org. Retrieved 2021-01-25. "Table ...
TRP-004 for toxoplasmosis, TRP-005 for epileptic encephalopathy, and TRP-011 for congenital metabolic disorder. "Leadership ... Daraprim is the trade name for the drug pyrimethamine, which is indicated for the treatment of toxoplasmosis in combination ... At the time of the Daraprim acquisition Turing Pharmaceuticals indicated that it intended to develop new toxoplasmosis drug ... The company has two marketed products: Daraprim (pyrimethamine), for the treatment of toxoplasmosis, and Vecamyl (mecamylamine ...
... syndrome A result of prematurity Causes from illness/infection Rubella AIDS Cytomegalovirus Congenital syphilis Toxoplasmosis ... The two overarching types of deafblindness are congenital and acquired.: 36-74 Congenital deafblindness: the condition of ... CHARGE syndrome Cochleosaccular degeneration with progressive cataracts Down syndrome Marshall syndrome Congenital rubella ...
Congenital toxoplasmosis is a group of symptoms that occur when an unborn baby (fetus) is infected with the parasite Toxoplasma ... Congenital toxoplasmosis is a group of symptoms that occur when an unborn baby (fetus) is infected with the parasite Toxoplasma ... Congenital toxoplasmosis is a group of symptoms that occur when an unborn baby (fetus) is infected with the parasite Toxoplasma ... Treatment of infants with congenital toxoplasmosis most often includes pyrimethamine, sulfadiazine, and leucovorin for one year ...
The most common finding in congenital toxoplasmosis is the ophthalmologic manifestation retinochoroiditis, which has a ... 3] Ocular toxoplasmosis is a leading cause of posterior uveitis. [4] Macular scar secondary to congenital toxoplasmosis. Visual ... Congenital Versus Acquired Ocular Toxoplasmosis. Early studies proposed that most cases of ocular toxoplasmosis were secondary ... Couvreur J, Desmonts G. Congenital and maternal toxoplasmosis. A review of 300 congenital cases. Dev Med Child Neurol. 1962 Oct ...
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
Freeman K, Oakley L, Pollak A, Buffolano W, Petersen E, Semprini AE, Association between congenital toxoplasmosis and preterm ... toxoplasmosis), 771.2a (a special KPNC subset code specifying toxoplasmosis), and those with the more general 771.2 (congenital ... Rate of Congenital Toxoplasmosis in Large Integrated Health Care Setting, California, USA, 1998-2012 On This Page ... Rate of Congenital Toxoplasmosis in Large Integrated Health Care Setting, California, USA, 1998-2012. Emerging Infectious ...
Congenital Toxoplasmosis in Goats, Congenital Toxoplasmosis in Humans and Domestic Animals (2018) 1: 96. https://doi.org/ ... Congenital Toxoplasmosis in Goats. Author(s): Helenara Machado da Silva, Jesaias Ismael da Costa, Alvimar Jose da Costa and *,0 ... Keywords: Clinical disorders, Clinical signs, Congenital problems, Control, Diagnosis, Epidemiology, Infection toxoplasmosis, ... In this way, the objective of this chapter is to describe the main aspects of congenital toxoplasmosis in pregnant goats, in ...
The diagnosis of congenital toxoplasmosis was ruled out in 34 cases, confirmed in ten cases, and doubtful in 8 cases. ... Western blot was evaluated for the neonatal diagnosis of congenital toxoplasmosis based on a comparison of antibody profiles ... in two cases Western blot would have provided the diagnosis of congenital toxoplasmosis two months before the secondary ... thus allowing early postdelivery diagnosis of congenital toxoplasmosis before the results of other tests are available. This ...
Education and information about Toxoplasmosis including diagnosis and treatment information for Health Professionals. ... CDC MMWR: Preventing Congenital Toxoplasmosis. *Maldonado YA, Read JS, AAP Committee on Infectious Diseases. Diagnosis, ... Use in children age 2 months and younger is contraindicated unless used in the treatment of congenital toxoplasmosis. ... Diagnosis, treatment, and prevention of congenital toxoplasmosis in the United States. Pediatrics. 2017;139(2):e20163860. ...
Kim, K 2006, Time to screen for congenital toxoplasmosis?, Clinical Infectious Diseases, vol. 42, no. 10, pp. 1395-1397. ... Kim K. Time to screen for congenital toxoplasmosis? Clinical Infectious Diseases. 2006 May 15;42(10):1395-1397. doi: 10.1086/ ... Time to screen for congenital toxoplasmosis? / Kim, Kami. In: Clinical Infectious Diseases, Vol. 42, No. 10, 15.05.2006, p. ... Time to screen for congenital toxoplasmosis?. In: Clinical Infectious Diseases. 2006 ; Vol. 42, No. 10. pp. 1395-1397. ...
Congenital Toxoplasmosis - Etiology, pathophysiology, symptoms, signs, diagnosis & prognosis from the MSD Manuals - Medical ... Etiology of Congenital Toxoplasmosis Congenital toxoplasmosis is almost exclusively due to a primary maternal infection during ... See also Toxoplasmosis Toxoplasmosis Toxoplasmosis is infection with Toxoplasma gondii. Symptoms range from none to benign ... Prognosis for Congenital Toxoplasmosis Some children have a fulminant course with early death, whereas others have long-term ...
Toxoplasmosis is caused by infection with the protozoan Toxoplasma gondii, an obligate intracellular parasite. The infection ... Congenital toxoplasmosis usually is a subclinical infection. Among immunodeficient individuals, toxoplasmosis most often occurs ... Discrimination between patients with acquired toxoplasmosis and congenital toxoplasmosis on the basis of the immune response to ... Congenital toxoplasmosis. Approximately 10-20% of pregnant women infected with T gondii become symptomatic. [18] The most ...
Humans, Pregnancy Complications, Parasitic, Toxoplasmosis, Congenital, Spiramycin, Antiprotozoal Agents, Pregnancy, Infant, ...
Toxoplasmosis is an infection caused by a parasite in cat feces and undercooked meat. Pregnant and immunocompromised people are ... Pregnant people with toxoplasmosis can also pass it on to the fetus. This is called congenital toxoplasmosis and can have ... Toxoplasmosis in children. Sometimes babies with congenital toxoplasmosis arent noticeably ill at birth but develop signs and ... Treatment of congenital toxoplasmosis. Newborns with signs or symptoms of toxoplasmosis are typically treated with a ...
Humans, Pregnancy Complications, Parasitic, Toxoplasmosis, Congenital, Spiramycin, Antiprotozoal Agents, Pregnancy, Infant, ... Clinical Trials of Therapeutics for the Prevention of Congenital Zika Virus Disease: Challenges and Potential Solutions ...
Toxoplasmosis can be transmitted to mice by the introduction of Toxoplasma into the vagina. Pregnant mice were more susceptible ... EXPERIMENTAL CONGENITAL TOXOPLASMOSIS : I. THE VAGINA AS A PORTAL OF ENTRY OF TOXOPLASMA IN THE MOUSE David Cowen, David Cowen ... David Cowen, Abner Wolf; EXPERIMENTAL CONGENITAL TOXOPLASMOSIS : I. THE VAGINA AS A PORTAL OF ENTRY OF TOXOPLASMA IN THE MOUSE ... EXPERIMENTAL CONGENITAL TOXOPLASMOSIS : III. T. OXOPLASMOSIS IN THE. O. FFSPRING OF. M. ICE. I. NFECTED BY THE. V. AGINAL. R. ...
Is congenital toxoplasmosis still an important clinical problem?. Ali Joman Alghamdi, Ali Alabbas, Monika Tadla, Catherine ...
Martin S (June 2001). "Congenital toxoplasmosis". Neonatal Network. 20 (4): 23-30. doi:10.1891/0730-0832.20.4.23. PMID 12143899 ... Amniocentesis can be used to detect other congenital infections such as cytomegalovirus, hepatitis B, parvovirus B19, and ... Tissues obtained from amniotic cell lines show significant promise for patients with congenital diseases/malformations of the ... Attwood LO, Holmes NE, Hui L (December 2020). "Identification and management of congenital parvovirus B19 infection". Prenatal ...
... it can be used for the diagnosis of congenital toxoplasmosis in association with other congenital infection markers. ... Congenital Toxoplasmosis; Diagnosis; Diagnóstico; Serology; Sorologia; Toxoplasmose Congênita; Western Blotting; Western ... 15 children (15.1%) met the criteria for congenital toxoplasmosis and 32 (32.3%) had the diagnosis excluded. The symptoms were ... Evaluation of the Western blotting method for the diagnosis of congenital toxoplasmosis. ...
... infants developed complications secondary to congenital toxoplasmosis such as microphthalmia, chorioretinitis, congenital ... The incidence of congenital toxoplasmosis estimated in 2013 by the World Health Organization was of 5/10,000 live births for ... Congenital toxoplasmosis occurs when a pregnant woman becomes infected during the gestation or when there is reactivation in an ... Congenital toxoplasmosis in a Portuguese tertiary hospital - report of 4 cases. Journal of Pediatric and Neonatal ...
Median annual health-care costs per serious case of congenital, adult-acquired, and human immunodeficiency virus (HIV)- ... of toxoplasmosis cases and accounted for over half of direct health-care costs associated with clinical toxoplasmosis. A One ... associated toxoplasmosis were $1,971, $763, and $5,744, respectively, with an overall cost of C$1,686,860 annually (2015 ... Annual incidence of serious toxoplasmosis and toxocariasis was 0.257 (95% confidence interval [CI]: 0.254-0.260) and 0.010 (95 ...
IVD 0303 -Congenital infections, rubella, toxoplasmosis. *IVD 0305 -Human infections: cytomegalovirus, chlamydia ...
Ocular toxoplasmosis is usually a late result of congenital transmission. A history of infectious diseases (eg, tuberculosis) ... Toxoplasmosis titers are useful only in the presence of at least somewhat typical retinitis scars. Angiotensin-converting ... A history of ingestion of raw or undercooked meat is important in arousing suspicion for ocular toxoplasmosis. Contact with ... Focal lesions are more characteristic of toxoplasmosis. Diffuse inflammation is seen in vasculitic or ischemic disease, and ...
Freeman K, Oakley L, Pollak A, Buffolano W, Petersen E, Semprini AE, Association between congenital toxoplasmosis and preterm ... toxoplasmosis), 771.2a (a special KPNC subset code specifying toxoplasmosis), and those with the more general 771.2 (congenital ... Rate of Congenital Toxoplasmosis in Large Integrated Health Care Setting, California, USA, 1998-2012. On This Page. *Letter ... Rate of congenital toxoplasmosis in large integrated health care setting, California, USA, 1998-2012 [letter]. Emerg Infect Dis ...
Title: Toxoplasma gondii: The changing paradigm of congenital toxoplasmosis Author. LINDSAY, D. - Virginia-Maryland Regional ... These differences impact much of what we used to believe as facts about congenital toxoplasmosis (CT) and will be important in ... Toxoplasma gondii: The changing paradigm of congenital toxoplasmosis. Parasitology. 138:1829-1831.. Interpretive Summary: ... In the present study, scientists review congenital toxoplasmosis in humans. The results will be of interest to biologists, ...
There surely are infections that cause severe birth defects-rubella (German measles) may cause deafness; toxoplasmosis may ... cause blindness and other neurologic problems; congenital syphilis has a hundred different manifestations. But a new virus ...
Finally, the prevalence of toxoplasmosis among U.S. adults was associated with demographic characteristics including age, ... T. gondii infection causes toxoplasmosis, which is the leading cause of death associated with foodborne diseases in the United ... European Research Network on Congenital Toxoplasmosis. BMJ 2000, 321, 142-147. [Google Scholar] [CrossRef] [PubMed][Green ... Toxoplasmosis. Toxoplasma gondii (T. gondii) is a widespread protozoan parasite that infects one-third of the world population ...
However, the development of an effective toxoplasmosis vaccine in humans remains a challenge to date. In this study, we ... Hence, we evaluated the protective immunity of ME49Δcdpk3 as a live attenuated vaccine against toxoplasmosis. Our results ... Toxoplasmosis, a common parasitic disease, is caused by Toxoplasma gondii, which infects approximately 30% of the worlds ... and chronic Toxoplasma infections with various strains and was a potential candidate to develop a vaccine against toxoplasmosis ...
Congenital toxoplasmosis. Genotyping techniques.. Molecular diagnostic techniques. Parasite load. Polymerase Chain Reaction. ... The genotype and the parasite load are two of the main factors associated with pathogenesis in congenital toxoplasmosis. In ... Study of parasite load and genotypes of Toxoplasma gondii in congenital toxoplasmosis ... We analyzed 76 amniotic fluid samples from pregnancies with toxoplasmosis and 31 controls. The qPCR presented LOD of 10 ...
Toxoplasmosis Worldwide; Wide reservoir in Sanitation and hygiene; None -- common infection; rodents, cats, swine, education of ... congenital immunity; relapses and treatment infections severe, fatal, or chronic Toxocariasis (visceral Chronic disease of ... Low congenital) especially urban; diagnosis difficult; treatment, condoms; ,=5% prevalence in serology; sexual education; ...
  • Congenital toxoplasmosis is a group of symptoms that occur when an unborn baby (fetus) is infected with the parasite Toxoplasma gondii . (medlineplus.gov)
  • Toxoplasmosis (Toxoplasma gondii). (medlineplus.gov)
  • Congenital transmission can occur when a woman is infected with Toxoplasma gondii during, or just before, pregnancy. (cdc.gov)
  • Diagnosis of toxoplasmosis is usually made by detection of Toxoplasma -specific IgG, IgM, IgA, or IgE antibodies. (cdc.gov)
  • Congenital toxoplasmosis is caused by transplacental acquisition of Toxoplasma gondii . (msdmanuals.com)
  • Toxoplasmosis Toxoplasmosis is infection with Toxoplasma gondii . (msdmanuals.com)
  • Toxoplasma gondii , a parasite found worldwide, causes congenital infection in about 1/10,000 to 80/10,000 births. (msdmanuals.com)
  • Toxoplasmosis can be transmitted to mice by the introduction of Toxoplasma into the vagina. (silverchair.com)
  • Toxoplasmosis is a parasitic disease caused by Toxoplasma gondii, an apicomplexan. (wikipedia.org)
  • To evaluate the Western blotting method for the detection of IgG anti- Toxoplasma gondii (T. gondii) ( IgG -WB) in the serum of children with suspected congenital toxoplasmosis . (bvsalud.org)
  • Toxoplasma gondii is an intracellular parasite responsible for toxoplasmosis, a zoonosis with a worldwide distribution. (jpnim.com)
  • Toxoplasmosis, a common parasitic disease, is caused by Toxoplasma gondii , which infects approximately 30% of the world's population. (nature.com)
  • These data demonstrated that ME49Δ cdpk3 inoculation induced effective cellular and humoral immune responses against acute and chronic Toxoplasma infections with various strains and was a potential candidate to develop a vaccine against toxoplasmosis. (nature.com)
  • The above characteristics of Toxoplasma strains pose great challenges to the control of toxoplasmosis. (nature.com)
  • Thus, the development of an effective toxoplasmosis vaccine is critical for limiting the infection of various Toxoplasma strains. (nature.com)
  • Toxoplasma gondii variant influences clinical profile in human congenital and ocular toxoplasmosis. (frontiersin.org)
  • Toxoplasmosis is a parasitic infection caused by Toxoplasma gondii . (glowm.com)
  • Approximately 1 to 2 cases of congenital toxoplasma occur per 10,000 children born. (glowm.com)
  • Maternal Anti- Toxoplasma Treatment during Pregnancy Is Associated with Reduced Sensitivity of Diagnostic Tests for Congenital Infection in the Neonate. (sutterhealth.org)
  • Toxoplasmosis Outbreak Associated With Toxoplasma gondii-Contaminated Venison-High Attack Rate, Unusual Clinical Presentation, and Atypical Genotype. (sutterhealth.org)
  • Toxoplasmosis infection can be passed to a developing baby if the mother becomes infected while pregnant. (medlineplus.gov)
  • For example, toxoplasmosis infection can be passed from cats if you clean the cat's litter box. (medlineplus.gov)
  • Early studies proposed that most cases of ocular toxoplasmosis were secondary to congenital infection and that they tended to occur during the chronic phase of infection. (medscape.com)
  • Because reports showed that up to 75% of patients with congenital toxoplasmosis had chorioretinal scars at birth, most cases of intraocular toxoplasmosis were believed to be secondary to reactivation of a congenital infection. (medscape.com)
  • however, serologic studies suggest that ocular toxoplasmosis is more commonly associated with acquired infection than was previously believed. (medscape.com)
  • Later studies demonstrated the importance of acquired infection in the pathogenesis of ocular toxoplasmosis. (medscape.com)
  • Wolf, Cowan, and Paige (1937-1939) determined that these findings represented the syndrome of severe congenital T gondii infection. (medscape.com)
  • Congenital toxoplasmosis usually is a subclinical infection. (medscape.com)
  • Among immunodeficient individuals, toxoplasmosis most often occurs in those with defects of T-cell-mediated immunity, such as those with hematologic malignancies, bone marrow and solid organ transplants, or acquired immunodeficiency syndrome ( AIDS ).In most immunocompetent individuals, primary or chronic (latent) T gondii infection is asymptomatic. (medscape.com)
  • Serologic testing is important in diagnosing maternal and congenital infection. (msdmanuals.com)
  • Keep reading to learn more about toxoplasmosis, how it's diagnosed and treated, and the steps you can take to avoid getting this parasitic infection. (healthline.com)
  • A cat with toxoplasmosis can shed millions of eggs in its feces for 1 to 3 weeks after infection. (healthline.com)
  • The high susceptibility of the pregnant mouse to toxoplasmosis under the conditions of these experiments suggests a possible explanation for the higher incidence of congenital as compared to postnatal human toxoplasmosis and for the associated asymptomatic maternal infection. (silverchair.com)
  • Infection has three stages: Acute toxoplasmosis is often asymptomatic in healthy adults. (wikipedia.org)
  • People with weakened immune systems are likely to experience headache, confusion, poor coordination, seizures, lung problems that may resemble tuberculosis or Pneumocystis jiroveci pneumonia (a common opportunistic infection that occurs in people with AIDS), or chorioretinitis caused by severe inflammation of the retina (ocular toxoplasmosis). (wikipedia.org)
  • Reviews of serological studies have estimated that 30-50% of the global population has been exposed to and may be chronically infected with latent toxoplasmosis, although infection rates differ significantly from country to country. (wikipedia.org)
  • therefore, it can be used for the diagnosis of congenital toxoplasmosis in association with other congenital infection markers. (bvsalud.org)
  • Congenital toxoplasmosis occurs when a pregnant woman becomes infected during the gestation or when there is reactivation in an immunocompromised pregnant woman of a previous latent infection. (jpnim.com)
  • Clinical manifestations of congenital infection can vary in severity, ranging from asymptomatic infection to abortion and still-birth. (jpnim.com)
  • T. gondii infection causes toxoplasmosis, which is the leading cause of death associated with foodborne diseases in the United States. (mdpi.com)
  • Toxoplasmosis is the most common parasitic infection worldwide, because it affects all homoeothermic species, including humans ( Montoya and Liesenfeld, 2004 ). (frontiersin.org)
  • According to a 1999 CDC report, toxoplasmosis is the third leading cause of death due to food borne infections and leads to an estimated 400 to 6,000 cases of congenital infection in the United States. (cdc.gov)
  • T. gondii type II strains, identified predominantly in the populations of some European countries and the United States, were reported to generate congenital toxoplasmosis, including lethal infection, severe neuro-ocular involvement, isolated chorioretinitis, and/or latent toxoplasmosis [ 7 ]. (springer.com)
  • When acquired during pregnancy, toxoplasmosis often goes unrecognized in the mother, but it can produce a severe congenital infection with ocular and neurologic damage to the infant. (glowm.com)
  • Education about the primary prevention of toxoplasmosis has decreased the rate of primary infection, but it is still an important pathogen. (glowm.com)
  • Antibody formation elicited in response to the parasite converts the parasite from the trophozoite to the tissue cyst form, and the parasite no longer circulates in blood to cause congenital infection. (glowm.com)
  • Thus, fetal infection has not been reported in women with chronic toxoplasmosis that occurred before pregnancy. (glowm.com)
  • I'm delighted to welcome you to today's COCA Call, Zika Update: Clinical Laboratory Testing and Care of Infants with Congenital Zika Infection . (cdc.gov)
  • At this conclusion of today's session, the participant will be able to interpret revised testing guidance for newborn with possible congenital Zika virus infection, discuss clinical evaluation of infants born to mothers with laboratory evidence of Zika virus infection and outline outpatient management of infants with laboratory evidence of congenital Zika virus infection with, and without, abnormalities consistent with congenital syndrome. (cdc.gov)
  • [ 10 ] Moreover, in a Canadian epidemic of toxoplasmosis, up to 21% of persons who were affected developed ocular lesions. (medscape.com)
  • [ 3 ] Ocular toxoplasmosis is a leading cause of posterior uveitis. (medscape.com)
  • Therapy for ocular toxoplasmosis. (cdc.gov)
  • Serology in ocular toxoplasmosis. (bmj.com)
  • No relation was observed between the level of the dye test titres and the diagnosis of ocular toxoplasmosis (groups I and II). (bmj.com)
  • Our study shows that the definite diagnosis of ocular toxoplasmosis or its exclusion by serological means only is not yet feasible. (bmj.com)
  • Approach to ocular toxoplasmosis including pregnant women. (sutterhealth.org)
  • congenital syphilis has a hundred different manifestations. (thedailybeast.com)
  • Despite an effective vaccine for rubella and reliable serological methods for detecting syphilis, these pathogens remain important potential causes of congenital infections. (researchgate.net)
  • This article describes the epidemiological factors that have contributed to the reemergence of these disorders and summarizes the clinical features, microbiological diagnosis, and strategies for treatment or prevention of congenital rubella and congenital syphilis. (researchgate.net)
  • Regarding the care provided to newborns, 28.6% did not undergo cerebrospinal fluid assessment and 23.9% did not perform long-bone radiography, which is essential for screening children exposed to congenital syphilis. (bvsalud.org)
  • Currently recommended treatment drugs for toxoplasmosis target the tachyzoite stage of the parasite and do not eradicate encysted parasites in the tissues. (cdc.gov)
  • Of those with the parasite, the people most at risk of serious illness are people with weakened immune systems and babies born to parents with toxoplasmosis. (healthline.com)
  • The name of the parasite that causes toxoplasmosis is T. gondii . (healthline.com)
  • Aside from congenital toxoplasmosis, which is passed from a pregnant parent to their baby, most people become infected when they ingest the T. gondii parasite. (healthline.com)
  • The genotype and the parasite load are two of the main factors associated with pathogenesis in congenital toxoplasmosis. (usp.br)
  • High parasite burdens were observed in all tissues except the central nervous system, and toxoplasmosis with severe protozoal steatitis was the primary cause of death for all cases. (frontiersin.org)
  • We conclude that studies on TLR contributions in the maternal-fetal transmission of particular parasite strains and congenital toxoplasmosis are warranted. (springer.com)
  • Congenital Toxoplasmosis in Goats, Congenital Toxoplasmosis in Humans and Domestic Animals (2018) 1: 96. (eurekaselect.com)
  • Overall, it's very rare for humans to get toxoplasmosis from cats. (healthline.com)
  • In the present study, scientists review congenital toxoplasmosis in humans. (usda.gov)
  • However, the development of an effective toxoplasmosis vaccine in humans remains a challenge to date. (nature.com)
  • The COUG genotype was first isolated from mountain lions in British Columbia, Canada during investigation of a waterborne outbreak of toxoplasmosis in humans. (frontiersin.org)
  • When infects humans, toxoplasmosis can cause blindness or congenital birth defects. (smithsonianmag.com)
  • In humans, type I and atypical strains usually associate with severe toxoplasmosis. (springer.com)
  • Hence, it was suggested that T. gondii strains virulent for mice might not lead to a similar course of toxoplasmosis in humans. (springer.com)
  • Infections with toxoplasmosis are associated with a variety of neuropsychiatric and behavioral conditions. (wikipedia.org)
  • In Europe and the USA, genotype II is the most prevalent in congenital infections, while in South America there is evidence pointing to a higher frequency of atypical or recombinant genotypes associated with more severe cases. (usp.br)
  • Supplement your learning for the ISUOG Course 'Diagnosis and Management of Congenital Infections' with the following learning resources. (isuog.org)
  • Join us for this one day online education course on Saturday 15h of May 2021 to learn about the diagnosis and management of congenital infections. (isuog.org)
  • Blueberry muffin baby" is a term describing the cutaneous manifestations of various congenital infections and neoplastic diseases. (thieme-connect.de)
  • The increased occurrence of microcephaly associated with cerebral damage characteristically seen in congenital infections in Zika virus-affected areas is suggestive of a possible relationship. (cdc.gov)
  • Tests for other congenital infections were negative. (cdc.gov)
  • The present findings on human toxoplasmosis in Gabon suggest that at an older age, reactivation of old infections seems more frequent than new infections , as indicated by the presence of T. gondii using PCR among elevated IgG subjects without IgM . (bvsalud.org)
  • Treatment of infants with congenital toxoplasmosis most often includes pyrimethamine, sulfadiazine, and leucovorin for one year. (medlineplus.gov)
  • In 2 out of the 4 cases, infants developed complications secondary to congenital toxoplasmosis such as microphthalmia, chorioretinitis, congenital hydrocephalus, diabetes insipidus, seizures, intracranial calcifications, central apnea and disturbances of the thermal regulation. (jpnim.com)
  • For these reasons we aimed to identify pregnancy, 40%-60% give birth to infected the true contribution of toxoplasmosis to infants. (who.int)
  • Combined clinical and in vitro studies showed that outbreaks of toxoplasmosis presented with asymptomatic to symptomatic courses related to the genotypes involved. (springer.com)
  • Up to half babies who become infected with toxoplasmosis during the pregnancy are born early (prematurely). (medlineplus.gov)
  • If a person becomes infected during pregnancy, a condition known as congenital toxoplasmosis may affect the child. (wikipedia.org)
  • Toxoplasmosis is usually spread by eating poorly cooked food that contains cysts, exposure to infected cat feces, and from an infected person to their baby during pregnancy. (wikipedia.org)
  • We accompanied 47 mothers with acquired toxoplasmosis in pregnancy and their children , between June of 2011 and June of 2014. (bvsalud.org)
  • This leaves about 62% of women at risk to acquire toxoplasmosis during pregnancy. (glowm.com)
  • Many young women in Jahrom Province are susceptible to primary toxoplasmosis during pregnancy, therefore, appropriate educational programmes to improve knowledge in this population should be implemented to prevent toxoplasmosis-related congenital malformations. (who.int)
  • Western blot was evaluated for the neonatal diagnosis of congenital toxoplasmosis based on a comparison of antibody profiles between serum samples obtained from the mother at delivery and from the neonate. (pasteur.fr)
  • Passively transferred antibodies can be distinguished from antibodies produced by the neonate, thus allowing early postdelivery diagnosis of congenital toxoplasmosis before the results of other tests are available. (pasteur.fr)
  • The diagnosis of congenital toxoplasmosis was ruled out in 34 cases, confirmed in ten cases, and doubtful in 8 cases. (pasteur.fr)
  • Importantly, in two cases Western blot would have provided the diagnosis of congenital toxoplasmosis two months before the secondary elevation in IgM titers in one case and three weeks before the result of mouse placenta inoculation in another case. (pasteur.fr)
  • Evaluation of the Western blotting method for the diagnosis of congenital toxoplasmosis. (bvsalud.org)
  • In this way, the objective of this chapter is to describe the main aspects of congenital toxoplasmosis in pregnant goats, in different gestational stages, infected and reinfected with T. gondii and their offspring. (eurekaselect.com)
  • Pregnant people with toxoplasmosis can also pass it on to the fetus. (healthline.com)
  • In 2020, 133 confirmed cases of congenital toxoplasmosis were reported in the EU/EEA, with France accounting for 83% of all the confirmed cases due to its active screening of pregnant women. (europa.eu)
  • The incidence of congenital toxoplasmosis estimated in 2013 by the World Health Organization was of 5/10,000 live births for the region where Portugal is inserted (European region A). In this study, we aimed to describe the cases of congenital toxoplasmosis in Centro Hospitalar Universitário de São João (CHUSJ) between January of 1999 and December of 2018. (jpnim.com)
  • In Europe and the United States, type II genotype is responsible for most cases of congenital toxoplasmosis. (medscape.com)
  • This is called congenital toxoplasmosis and can have serious consequences like miscarriage or stillbirth . (healthline.com)
  • Miscarriage, abortion, and congenital toxoplasmosis are also possible. (frontiersin.org)
  • Approximately 200,000 cases of congenital toxoplasmosis occur a year. (wikipedia.org)
  • About 75 percent of newborns born with toxoplasmosis don't have any noticeable symptoms at birth. (healthline.com)
  • Sometimes babies with congenital toxoplasmosis aren't noticeably ill at birth but develop signs and symptoms as they get older. (healthline.com)
  • Cats don't usually show symptoms of toxoplasmosis. (healthline.com)
  • Due to the absence of obvious symptoms, hosts easily become infected with T. gondii and develop toxoplasmosis without knowing it. (wikipedia.org)
  • When symptoms are seen, they are toxoplasmosis which created a type of pan- most frequently mild and the disease pic- ic reaction in the population. (who.int)
  • however, there are exceptions, including reinfection with a new serotype of T. gondii or reactivation of toxoplasmosis in mothers with severe cell-mediated immunodeficiencies. (msdmanuals.com)
  • Mothers with toxoplasmosis must be completely informed of the disease's potential consequences to the fetus. (medscape.com)
  • Although congenital toxoplasmosis occurs throughout the United States, little information is available about the rates of diagnosed illness in most of the nation, including California. (cdc.gov)
  • Rarely, it may gain access through the choroidal circulation as evidenced by the cases of punctate outer retinal toxoplasmosis where the RPE and the outer retina are selectively affected. (medscape.com)
  • Our goal was to determine the rate of clinically identified cases of congenital toxoplasmosis in children from birth to 2 years of age within the Northern California Kaiser Permanente Medical Care Program (KPNC) during a 15-year period. (cdc.gov)
  • After electronic and paper charts were reviewed, 2 cases of congenital toxoplasmosis were confirmed. (cdc.gov)
  • In some cases, congenital toxoplasmosis can be detected alongside irregularities in a baby's brain and eyes. (healthline.com)
  • We are not aware of any published cases neither of confirmed congenital toxoplasmosis nor of any of its complications in Portugal. (jpnim.com)
  • Macular scar secondary to congenital toxoplasmosis. (medscape.com)
  • Peripapillary scars secondary to toxoplasmosis. (medscape.com)
  • Pyrimethamine, considered the most effective drug against toxoplasmosis, is a standard component of therapy. (cdc.gov)
  • Rural areas (villages) were selected immunocompetent persons characterize toxoplasmosis. (bvsalud.org)
  • Individuals at risk for toxoplasmosis include fetuses, newborns, and immunologically impaired patients. (medscape.com)
  • However, due to the inherent difficulty in diagnosing acute toxoplasmosis, physicians are advised to seek confirmatory testing through the reference laboratory at Palo Alto Medical Foundation / Jack S. Remington Laboratory for Specialty Diagnostics. (cdc.gov)
  • The toxoplasmic trophozoites causing acute toxoplasmosis are referred to as tachyzoites, and are typically found in various tissues and body fluids, but rarely in blood or cerebrospinal fluid. (wikipedia.org)
  • Young children and immunocompromised people, such as those with HIV/AIDS, those taking certain types of chemotherapy, or those who have recently received an organ transplant, may develop severe toxoplasmosis. (wikipedia.org)
  • There were no infant deaths for which congenital toxoplasmosis was recorded as a cause. (cdc.gov)
  • The most frequent anomalies involve palatal function, facial features and congenital cardiac defects. (researchgate.net)
  • Survey of European programmes for the epidemiological surveillance of congenital toxoplasmosis.Euro Surveill 2008, 13, 1883-4. (oslo-universitetssykehus.no)
  • From February 2020 to March 2022, four southern sea otters ( Enhydra lutris nereis ) stranded in California with severe protozoal steatitis and systemic toxoplasmosis. (frontiersin.org)
  • The most common finding in congenital toxoplasmosis is the ophthalmologic manifestation retinochoroiditis, which has a predilection for the posterior pole. (medscape.com)
  • Acute macular retinitis associated with primary acquired toxoplasmosis, requiring immediate systemic therapy. (medscape.com)
  • 2019). Moreover, congenital transmission population. (bvsalud.org)
  • Serologic tests are available to determine who has become infected with toxoplasmosis. (cdc.gov)