Trophoblastic growth, which may be gestational or nongestational in origin. Trophoblastic neoplasia resulting from pregnancy is often described as gestational trophoblastic disease to distinguish it from germ cell tumors which frequently show trophoblastic elements, and from the trophoblastic differentiation which sometimes occurs in a wide variety of epithelial cancers. Gestational trophoblastic growth has several forms, including HYDATIDIFORM MOLE and CHORIOCARCINOMA. (From Holland et al., Cancer Medicine, 3d ed, p1691)
Trophoblastic hyperplasia associated with normal gestation, or molar pregnancy. It is characterized by the swelling of the CHORIONIC VILLI and elevated human CHORIONIC GONADOTROPIN. Hydatidiform moles or molar pregnancy may be categorized as complete or partial based on their gross morphology, histopathology, and karyotype.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
A malignant metastatic form of trophoblastic tumors. Unlike the HYDATIDIFORM MOLE, choriocarcinoma contains no CHORIONIC VILLI but rather sheets of undifferentiated cytotrophoblasts and syncytiotrophoblasts (TROPHOBLASTS). It is characterized by the large amounts of CHORIONIC GONADOTROPIN produced. Tissue origins can be determined by DNA analyses: placental (fetal) origin or non-placental origin (CHORIOCARCINOMA, NON-GESTATIONAL).
A uterine tumor derived from persistent gestational TROPHOBLASTS, most likely after a molar pregnancy (HYDATIDIFORM MOLE). Invasive hyadatiform mole develops in about 15% of patients after evacuation of a complete mole and less frequently after other types of gestation. It may perforate the MYOMETRIUM and erode uterine vessels causing hemorrhage.
Tumors or cancer of the UTERUS.
NATIONAL LIBRARY OF MEDICINE service for health professionals and consumers. It links extensive information from the National Institutes of Health and other reviewed sources of information on specific diseases and conditions.

Gestational trophoblastic disease: does central nervous system chemoprophylaxis have a role? (1/110)

In the UK there are standardized surveillance procedures for gestational trophoblastic disease. However, there are differences in practice between the two treatment centres in terms of definition of persistent gestational trophoblastic disease, prognostic risk assessment and chemotherapeutic regimens. The role of prophylactic chemotherapy for cerebral micrometastatic disease in persistent gestational trophoblastic disease is unclear. We have analysed the outcome of 69 patients with lung metastases who elsewhere might have received prophylactic intrathecal chemotherapy. Of the 69 patients, 67 received intravenous chemotherapy only. The other two patients had cerebral metastases at presentation. One patient who received only intravenous chemotherapy subsequently developed a cerebral metastasis, but this patient's initial treatment was compromised by non-compliance. This experience supports our current policy of not treating patients with pulmonary metastases, without clinical evidence of central nervous system (CNS) involvement, with prophylactic intrathecal therapy.  (+info)

Early pregnancy human chorionic gonadotropin (hCG) isoforms measured by an immunometric assay for choriocarcinoma-like hCG. (2/110)

Human chorionic gonadotropin (hCG) exhibits molecular heterogeneity in both its protein and carbohydrate moieties. This communication describes changes in hCG isoforms detected directly in clinical samples. These isoforms, quantified in blood or urine specimens, show a progression of change throughout normal pregnancy. Early pregnancy produces a type of hCG that resembles, in terms of immunoreactivity, a major form of hCG excreted in choriocarcinoma. The isoforms predominate for the first 5-6 weeks of gestation and then diminish, being replaced with the hCG isoforms which predominate throughout the remainder of pregnancy. The alteration in hCG isoform content occurs in both blood and urine. The progression of isoforms is best delineated by calculating the change in the ratio of the two forms, as many hCG assays either do not detect or fail to discriminate among these isoforms. An analogous pattern of hCG isoforms was observed in patients with in vitro fertilization pregnancies. hCG isolated from the pituitary displayed binding characteristics similar to those of the hCG derived from normal pregnancy urine. The early pregnancy hCG isoforms appear to have a differential expression in normal pregnancy as opposed to pregnancies which will not carry to term, suggesting that a determination of the relative balance of hCG isoforms may have diagnostic application in predicting pregnancy outcome.  (+info)

Oral contraceptive use and risk of gestational trophoblastic tumors. (3/110)

BACKGROUND: Gestational trophoblastic disease refers to a spectrum of rare benign and malignant gynecologic disorders whose pathogenesis is not well understood. Recent studies from China and the United States have raised the hypothesis that long-term use of oral contraceptives before conception may increase the risk of gestational trophoblastic tumors. A multicenter case-control study of gestational trophoblastic tumors was undertaken to test this hypothesis. METHODS: Telephone interviews were conducted with 235 case patients, including 50 with gestational choriocarcinoma, and 413 control subjects matched on recentness of pregnancy, age at pregnancy, and area of residence. Relative risks (odds ratios) were computed by conditional logistic regression. Reported P values are two-sided. RESULTS: The relative risk estimate for ever having used oral contraceptives before the index pregnancy was 1.9 (95% confidence interval [CI] = 1.2-3.0), and the risk increased with duration of use (P for trend = .05). The estimate was highest for women who used oral contraceptives during the cycle in which they became pregnant (relative risk = 4.0; 95% CI=1.6-10), but there was no consistent pattern according to the time interval since last use. Separate analyses of choriocarcinoma and persistent mole yielded similar results, i.e., the relative risk estimates for oral contraceptive use were 2.2 (95% CI=0.8-6.4) and 1.8 (95% CI=1.0-3.0), respectively. Control for the number of sexual partners, which was independently associated with risk (P for trend = .05), did not materially change the results. CONCLUSIONS: This study, the largest to date, indicates that long duration of oral contraceptive use before conception increases the risk of gestational trophoblastic tumors. These findings may provide clues to the pathogenesis of this rare disease. Changes in use of oral contraceptives are not warranted, however, because the incidence attributable to oral contraceptive use is very low.  (+info)

Structure, pathology and function of the N-linked sugar chains of human chorionic gonadotropin. (4/110)

Human chorionic gonadotropin (hCG) contains five acidic N-linked sugar chains, which are derived from three neutral oligosaccharides by sialylation. Each of the two subunits (hCGalpha and hCGbeta) of hCG contain two glycosylated Asn residues. Glycopeptides, each containing a single glycosylated Asn, were obtained by digestion of hCGalpha with trypsin, and of hCGbeta with chymotrypsin and lysyl endopeptidase. Comparative study of the sugar chains of the four glycopeptides revealed the occurrence of site-directed glycosylation. Studies of the sugar chains of hCGs, purified from urine of patients with various trophoblastic diseases, revealed that choriocarcinoma hCGs contain sialylated or non-sialylated forms of eight neutral oligosaccharides. In contrast, hCGs from invasive mole patients contain sialyl derivatives of five neutral oligosaccharides. The structural characteristics of the five neutral oligosaccharides, detected in choriocarcinoma hCGs but not in normal placental hCGs, indicate that N-acetylglucosaminyltransferase IV (GnT-IV) is abnormally expressed in the malignant cells. This supposition was confirmed by molecular biological study of GnT-IV in placenta and choriocarcinoma cell lines. The appearance of tumor-specific sugar chains in hCG has been used to develop a diagnostic method of searching for malignant trophoblastic diseases. In addition, a summary of the current knowledge concerning the functional role of N-linked sugar chains in the expression of the hormonal activity of hCG has been presented.  (+info)

Serosal complications of single-agent low-dose methotrexate used in gestational trophoblastic diseases: first reported case of methotrexate-induced peritonitis. (5/110)

Methotrexate (MTX) is a folate antagonist widely used both as an anticancer drug and as an immunosupressant. Administration of an 8-day methotrexate and folinic acid regime may be associated with pleuritic chest pain and pneumonitis. We have reviewed the toxicity seen in 168 consecutive patients treated with low-dose MTX for persistent trophoblastic disease. Twenty-five per cent of patients developed serosal symptoms, pleurisy was the commonest complaint. The majority of patients had mild to moderate symptoms which were controlled with simple analgesia and did not necessitate a change in treatment; 11.9% had severe symptoms which necessitated a change in treatment. One patient developed a pericardial effusion and a second patient developed severe reversible peritoneal irritation. The possible aetiology and pathophysiology of methotrexate-induced serosal toxicity is discussed.  (+info)

Etoposide and cisplatin/etoposide, methotrexate, and actinomycin D (EMA) chemotherapy for patients with high-risk gestational trophoblastic tumors refractory to EMA/cyclophosphamide and vincristine chemotherapy and patients presenting with metastatic placental site trophoblastic tumors. (6/110)

PURPOSE: To evaluate the results of etoposide, cisplatin/etoposide, methotrexate, and actinomycin D (EP/EMA) chemotherapy in patients with gestational trophoblastic tumors (GTTs), who have relapsed after or who have become refractory to EMA/cyclophosphamide and vincristine (CO) chemotherapy, and in patients presenting with metastatic placental site trophoblastic tumors (PSTTs). PATIENTS AND METHODS: We have treated a total of 34 patients with GTT and eight patients with metastatic PSTT with the EP/EMA chemotherapy schedule. RESULTS: Twenty-two patients received EP/EMA because of apparent drug resistance to EMA/CO, and because the human chorionic gonadotropin (hCG) was near normal, they were not assessable for response. Twenty-one of these patients (95%) are alive and in remission. In the group where the hCG was high enough to confirm a response (greater than one log fall in hCG) to EP/EMA, all 12 patients responded and nine of these patients (75%) are alive and in remission. We have treated three patients with PSTT where the interval from antecedent pregnancy was less than 2 years, and all patients (100%) are alive and in remission. We have treated five patients where the interval from antecedent pregnancy was greater than 2 years and one fifth (20%) remain in remission. The survival for patients with GTT is 30 (88%) out of 34 patients and four (50%) out of eight patients for PSTT, giving an overall survival for these two cohorts of 34 (81%) out of 42 patients. The toxicity of this schedule is significant, with grade 3 or 4 toxicity (National Cancer Institute common toxicity criteria) recorded in hemoglobin (21%), WBC (68%), and platelets (40%). The role of surgery in this group of patients is important and contributed to sustained remission in five patients (23%) and possibly helped an additional seven patients (32%). CONCLUSION: EP/EMA is an effective but moderately toxic regimen for patients with high-risk GTT who become refractory to or relapse from EMA/CO chemotherapy. Also, EP/EMA clearly has activity in patients with metastatic PSTT.  (+info)

Treatment of persistent trophoblastic disease later than 6 months after diagnosis of molar pregnancy. (7/110)

Of 4257 patients with gestational trophoblastic disease (GTD) registered between 1986 and 1996 with the Trophoblastic Screening and Treatment Centre, Sheffield, 231 women required chemotherapy; 28 were treated 24 weeks or more after the initial evacuation of products of conception. In 18 patients late treatment was a result of a predetermined watch and wait policy on the part of the Centre; these patients formed the study group. Patients were identified from the Centre's computer database. The time interval from first evacuation (diagnosis) to start of chemotherapy was calculated for each patient. Hospital records were reviewed when the interval of observation was 24 weeks or greater to determine patient characteristics, treatment and outcome. Eighteen women were treated 'late' (according to Centre policy), with a median age of 30 years (range 21-57 years). The interval from diagnosis to treatment ranged from 24 to, in one case, 56 weeks (median 33 weeks). Fourteen of 18 women had complete moles, 3/18 had partial moles and one had unclassified disease. All women had low-risk disease and were treated with single-agent methotrexate; 17 were cured with this regimen, one also required salvage chemotherapy. In conclusion, where a successful surveillance programme is in operation for GTD, a wait and watch policy can be adopted without compromising patients whose definitive treatment is commenced more than 6 months after the initial diagnosis.  (+info)

Persistent gestational trophoblastic disease: results of MEA (methotrexate, etoposide and dactinomycin) as first-line chemotherapy in high risk disease and EA (etoposide and dactinomycin) as second-line therapy for low risk disease. (8/110)

Persistent gestational trophoblastic disease is potentially fatal, but the majority of patients are cured with chemotherapy. Any developments in treatment are therefore being directed towards maintaining efficacy and reducing toxicity. We evaluated efficacy and toxicity of methotrexate, etoposide and dactinomycin (MEA) as first-line therapy for high risk disease and etoposide and dactinomycin (EA) as second-line therapy for methotrexate-refractory low risk disease in a retrospective analysis of 73 patients (38 MEA, 35 EA) treated since 1986 at a supra-regional centre. The median follow-up period was 5.5 years and the median number of cycles received was 7. The overall complete response rate was 85% (97% for EA, 75% for MEA). Of eight patients who failed to respond, four have since died and four were cured with platinum-based chemotherapy. Alopecia was universal. Grade II or worse nausea, emesis, or stomatitis was observed in 29%, 30% and 37% respectively. Fifty-one per cent experienced grade II/III anaemia, 8% grade II or higher thrombocytopenia and 64% grade III or IV neutropenia; in six cases this was complicated by sepsis. Fifty-four per cent of patients went on to have a normal pregnancy. No patient has developed a second malignancy. In conclusion, the MEA and EA chemotherapy regimens for persistent trophoblastic disease are very well tolerated, do not appear to affect future fertility and are associated with excellent, sustained complete response rates.  (+info)

Trophoblastic neoplasms are a group of rare tumors that originate from the trophoblast, which is the outer layer of cells that surrounds a developing embryo and helps to form the placenta during pregnancy. These tumors can be benign or malignant and are characterized by their ability to produce human chorionic gonadotropin (hCG), a hormone that is normally produced during pregnancy.

There are several types of trophoblastic neoplasms, including:

1. Hydatidiform mole: A benign growth that forms in the uterus when a fertilized egg implants but does not develop into a normal embryo. There are two types of hydatidiform moles: complete and partial. Complete moles have no fetal tissue, while partial moles have some fetal tissue.
2. Invasive mole: A malignant form of hydatidiform mole that invades the uterine wall and may spread to other parts of the body.
3. Choriocarcinoma: A rapidly growing and highly invasive malignant tumor that can arise from a hydatidiform mole, a normal pregnancy, or an ectopic pregnancy. It can spread quickly to other parts of the body, such as the lungs, liver, and brain.
4. Placental site trophoblastic tumor (PSTT): A rare type of trophoblastic neoplasm that arises from the cells that attach the placenta to the uterine wall. It is usually slow-growing but can be aggressive in some cases.
5. Epithelioid trophoblastic tumor (ETT): Another rare type of trophoblastic neoplasm that arises from the cells that form the placental villi. It is typically low-grade and has a good prognosis, but it can recur in some cases.

The treatment for trophoblastic neoplasms depends on the type and stage of the tumor. Treatment options may include surgery, chemotherapy, radiation therapy, or a combination of these approaches. Regular monitoring of hCG levels is also important to ensure that the tumor has been completely removed and to detect any recurrence early.

A hydatidiform mole, also known as a molar pregnancy, is a type of gestational trophoblastic disease (GTD), which is a group of rare disorders that involve abnormal growth of the placental tissue.

In a hydatidiform mole, there is an abnormal fertilization event leading to the growth of a mass of grapelike cysts in the uterus instead of a normal pregnancy. The chromosomes from the sperm and egg do not combine properly, resulting in an extra set of chromosomes, which leads to the development of the mole.

Hydatidiform moles can be complete or partial:

* Complete hydatidiform mole (CHM): This type arises when an egg without a nucleus is fertilized by one or two sperm, leading to the growth of abnormal placental tissue with no embryo. The chromosomes come from the father only, and there are typically 46 chromosomes, all of paternal origin.
* Partial hydatidiform mole (PHM): This type occurs when an egg is fertilized by two sperm or a single sperm that duplicates itself, resulting in an abnormal placenta with some fetal tissue. The chromosomes are of both maternal and paternal origin, and the placental tissue has a mix of normal and abnormal cells.

Hydatidiform moles can cause vaginal bleeding, rapid uterine enlargement, and high levels of human chorionic gonadotropin (hCG) hormone in the blood. They are usually detected during an ultrasound exam and require medical treatment to prevent complications such as gestational trophoblastic neoplasia, a malignant form of GTD that can spread to other organs.

An encyclopedia is a comprehensive reference work containing articles on various topics, usually arranged in alphabetical order. In the context of medicine, a medical encyclopedia is a collection of articles that provide information about a wide range of medical topics, including diseases and conditions, treatments, tests, procedures, and anatomy and physiology. Medical encyclopedias may be published in print or electronic formats and are often used as a starting point for researching medical topics. They can provide reliable and accurate information on medical subjects, making them useful resources for healthcare professionals, students, and patients alike. Some well-known examples of medical encyclopedias include the Merck Manual and the Stedman's Medical Dictionary.

Choriocarcinoma is a rapidly growing and invasive type of gestational trophoblastic disease (GTD), which are abnormal growths that develop in the tissues that are supposed to become the placenta during pregnancy. It occurs when a malignant tumor develops from trophoblast cells, which are normally found in the developing embryo and help to form the placenta.

Choriocarcinoma can occur after any type of pregnancy, including normal pregnancies, molar pregnancies (a rare mass that forms inside the uterus after conception), or ectopic pregnancies (when a fertilized egg implants outside the uterus). It is characterized by the presence of both trophoblastic and cancerous cells, which can produce human chorionic gonadotropin (hCG) hormone.

Choriocarcinoma can spread quickly to other parts of the body, such as the lungs, liver, brain, or vagina, through the bloodstream. It is important to diagnose and treat choriocarcinoma early to prevent serious complications and improve the chances of a successful treatment outcome. Treatment typically involves surgery, chemotherapy, or radiation therapy.

An invasive hydatidiform mole (IHM) is a rare and aggressive complication of a gestational trophoblastic disease (GTD), which itself originates from the abnormal proliferation of trophoblastic cells, the tissue that normally develops into the placenta during pregnancy. IHMs are characterized by the invasion of molar villi into the myometrium (the muscular layer of the uterus) and can potentially spread to other organs through the bloodstream, leading to distant metastases.

IHMs usually arise from a complete hydatidiform mole (CHM), which is an abnormal conceptus with no embryonic or fetal development. CHMs are typically diploid and originate from the fertilization of an egg without genetic material (an empty egg or an egg with two sets of paternal chromosomes) by one or two sperm cells. This results in a conceptus with only paternal chromosomes, which leads to uncontrolled proliferation of trophoblastic tissue and the formation of grapelike vesicles filled with fluid (hydatidiform moles).

Invasive hydatidiform moles can cause various symptoms, such as vaginal bleeding, pelvic pain, or the presence of an enlarged uterus. They also pose a risk for developing choriocarcinoma, another type of gestational trophoblastic neoplasia (GTN), which is a malignant tumor that can metastasize and spread to other organs. Proper diagnosis and timely treatment are crucial to prevent severe complications and improve the prognosis for patients with IHMs. Treatment usually involves surgical removal of the mole, followed by chemotherapy to eliminate any residual disease and reduce the risk of GTN development.

Uterine neoplasms refer to abnormal growths in the uterus, which can be benign (non-cancerous) or malignant (cancerous). These growths can originate from different types of cells within the uterus, leading to various types of uterine neoplasms. The two main categories of uterine neoplasms are endometrial neoplasms and uterine sarcomas.

Endometrial neoplasms develop from the endometrium, which is the inner lining of the uterus. Most endometrial neoplasms are classified as endometrioid adenocarcinomas, arising from glandular cells in the endometrium. Other types include serous carcinoma, clear cell carcinoma, and mucinous carcinoma.

Uterine sarcomas, on the other hand, are less common and originate from the connective tissue (stroma) or muscle (myometrium) of the uterus. Uterine sarcomas can be further divided into several subtypes, such as leiomyosarcoma, endometrial stromal sarcoma, and undifferentiated uterine sarcoma.

Uterine neoplasms can cause various symptoms, including abnormal vaginal bleeding or discharge, pelvic pain, and difficulty urinating or having bowel movements. The diagnosis typically involves a combination of imaging tests (such as ultrasound, CT, or MRI scans) and tissue biopsies to determine the type and extent of the neoplasm. Treatment options depend on the type, stage, and patient's overall health but may include surgery, radiation therapy, chemotherapy, or hormone therapy.

MedlinePlus is not a medical term, but rather a consumer health website that provides high-quality, accurate, and reliable health information, written in easy-to-understand language. It is produced by the U.S. National Library of Medicine, the world's largest medical library, and is widely recognized as a trusted source of health information.

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"References: Gestational Trophoblastic Disease". www.cancer.org. 25 June 2012. Retrieved 2020-12-16. "Gestational Trophoblastic ... "Epithelioid trophoblastic tumor", Definitions, Qeios, 2020-02-10, doi:10.32388/ka4bji "Gestational Trophoblastic Neoplasia ... "Gestational Trophoblastic Disease - Diagnosis". Cancer.Net. 2012-06-25. Retrieved 2020-12-16. "Gestational Trophoblastic ... placental site trophoblastic tumor (PSTT) and epithelioid trophoblastic tumor (ETT). The choriocarcinoma has 2 significant ...
Trophoblastic neoplasms Seckl MJ, Sebire NJ, Berkowitz RS (August 2010). "Gestational trophoblastic disease". Lancet. 376 (9742 ... Gestational trophoblastic disease (GTD) may also be called gestational trophoblastic tumour (GTT). Hydatidiform mole (one type ... The four malignant tumours Invasive mole Choriocarcinoma Placental site trophoblastic tumour Epithelioid trophoblastic tumour ... Lurain JR (January 2011). "Gestational trophoblastic disease II: classification and management of gestational trophoblastic ...
Tumors that express keratin include carcinomas, thymomas, sarcomas and trophoblastic neoplasms. Furthermore, the precise ...
This includes Wilms tumor, rhabdomyosarcoma, Ewing's sarcoma, trophoblastic neoplasm, testicular cancer, and certain types of ... Gestational trophoblastic neoplasia Wilms' tumor Rhabdomyosarcoma Ewing's sarcoma Malignant hydatidiform mole Sometimes it will ... chemotherapy in gestational trophoblastic neoplasia". International Journal of Gynecological Cancer. 16 (3): 1432-1438. doi: ...
... trophoblastic neoplasms, and ovarian carcinoma. Moreover, it also has been used as an immunosuppressive drug for various ...
... gestational trophoblastic diseases (GTD), and gestational trophoblastic neoplasms). bacterial contamination and blood in urine ...
Trisomy 14 mosaicism Trisomy 2 mosaicism Trisomy 3 mosaicism Trisomy 6 Trisomy Trochlear dysplasia Trophoblastic Neoplasms ( ... gestational trophoblastic disease) Trophoblastic tumor Tropical spastic paraparesis Tropical sprue Troyer syndrome Trueb-Burg- ... Temtamy-Shalash syndrome TEN Ter Haar-Hamel-Hendricks syndrome Ter Haar syndrome Teratocarcinosarcoma Teratoma Testes neoplasm ... mental retardation Thymic carcinoma Thymic epithelial tumor Thymic renal anal lung dysplasia Thymoma Thymus neoplasm ...
... trophoblastic tumor, placental site MeSH C04.557.465.955.416 - gestational trophoblastic neoplasms MeSH C04.557.465.955.416.202 ... gestational trophoblastic neoplasms MeSH C04.850.908.416.186 - choriocarcinoma MeSH C04.850.908.416.186.875 - trophoblastic ... skull base neoplasms MeSH C04.588.149.828 - spinal neoplasms MeSH C04.588.180.260 - breast neoplasms, male MeSH C04.588.180.390 ... bile duct neoplasms MeSH C04.588.274.120.250.250 - common bile duct neoplasms MeSH C04.588.274.120.401 - gallbladder neoplasms ...
... decidual vasculopathy Chorangiosis Chorangioma Placental infarction Trophoblastic neoplasms derive from trophoblastic tissue. ...
... trophoblastic tumors, and neoplasms of gonads Other malignant epithelial neoplasms and malignant melanomas Other and ... diseases Lymphomas and reticuloendothelial neoplasms CNS and miscellaneous intracranial and intraspinal neoplasms Neuroblastoma ... unspecified malignant neoplasms "International Classification of Childhood Cancer (ICCC)". National Cancer Institute. Retrieved ...
... and choriocarcinoma and other trophoblastic neoplasms. Although originally designed as a chemotherapy drug, in lower doses ... Types of cancers it is used for include breast cancer, leukemia, lung cancer, lymphoma, gestational trophoblastic disease, and ... a study of 93 patients with incurable neoplasms". Journal of the National Medical Association. 43 (4): 211-40. PMC 2616951. ...
A placental site trophoblastic tumor is a monophasic neoplasm of the implantation site intermediate trophoblast, and usually a ... Placental site trophoblastic tumor is a form of gestational trophoblastic disease, which is thought to arise from intermediate ... Shih IM, Kurman RJ (January 2001). "The pathology of intermediate trophoblastic tumors and tumor-like lesions". International ... Whitney KA (December 2009). "Placental site trophoblastic tumor". The American Journal of Nursing. 109 (12): 32-7, quiz 38. doi ...
... trophoblastic neoplasms MeSH C13.703.720.949.416 - gestational trophoblastic neoplasms MeSH C13.703.720.949.416.218 - ... vaginal neoplasms MeSH C13.371.820.800.418.968 - vulvar neoplasms MeSH C13.371.820.800.820 - urologic neoplasms MeSH C13.371. ... fallopian tube neoplasms MeSH C13.371.820.800.418.685 - ovarian neoplasms MeSH C13.371.820.800.418.685.265 - brenner tumor MeSH ... ureteral neoplasms MeSH C13.371.820.800.820.890 - urethral neoplasms MeSH C13.371.852.150 - uterine cervical diseases MeSH ...
Prostate cancer Testicular cancer Gestational trophoblastic tumor Ureter and renal pelvis, transitional cell cancer(urothelial ... Marginal zone B-cell lymphoma Mast cell leukemia Mediastinal large B cell lymphoma Multiple myeloma/plasma cell neoplasm ...
Gershinibaruch-Leibo syndrome Gerstmann syndrome Gestational diabetes mellitus Gestational pemphigoid Gestational trophoblastic ... neuroendocrine tumor Gastroenteritis Gastroesophageal reflux Gastrointestinal autonomic nerve tumor Gastrointestinal neoplasm ...
The presence of multiloculation suggests a neoplasm, although the thin septation implies that the neoplasm is benign. For any ... in particular gestational trophoblastic disease. Ovarian hyperstimulation occurs more often with invasive moles and ...
It is a malignant neoplasm and is one of the most treatable and curable cancers, with a survival rate above 95% if discovered ... These areas of hemorrhage usually correspond to trophoblastic cell clusters within the tumour. Microscopic examination shows ...
A study of 93 patients with incurable neoplasms". J Natl Med Assoc. 43 (4): 211-240. PMC 2616951. PMID 14850976. Li, MC; Hertz ... Li MC, Hertz R, Bergenstal DM (July 1958). "Therapy of choriocarcinoma and related trophoblastic tumors with folic acid and ... a germ-cell malignancy that originates in trophoblastic cells of the placenta. In 1960 Wright et al. produced remissions in ...
... gestational trophoblastic disease - gestational trophoblastic neoplasia - gestational trophoblastic tumor - GI14721 - giant ... neoplasm - nephrotomogram - nephrotoxic - nephroureterectomy - nerve block - nerve grafting - nerve-sparing radical ... Hürthle cell neoplasm - hydrazine sulfate - hydromorphone - hydronephrosis - hydroureter - hydroxychloroquine - hydroxyurea - ...
Research areas include iron-deficiency Anemia, neoplasms of blood and infectious diseases. One among the expert committee which ... The OB-GYN department administers the postpartum, family-welfare counseling, infertility, trophoblastic, adolescent and ...
NOS M8000/6 Neoplasm, metastatic Neoplasm, metastatic Tumor, metastatic Tumor, secondary Tumor embolus M8000/9 Neoplasm, ... trophoblastic M9103/0 Partial hydatidiform mole M9104/1 Placental site trophoblastic tumor M9105/3 Trophoblastic tumor, ... benign M8000/1 Neoplasm, uncertain whether benign or malignant Neoplasm, NOS Tumor, NOS Unclassified tumor, uncertain whether ... M8130/1 Papillary transitional cell neoplasm of low malignant potential (C67._) Papillary urothelial neoplasm of low malignant ...
Dirnhofer, S; M Freund; H Rogatsch; S Krabichler; P Berger (2000). "Selective expression of trophoblastic hormones by lung ... hCG was discovered to be expressed in certain kinds of malignant neoplasms, including breast cancer, adenocarcinoma of the ... Dirnhofer S, Koessler P, Ensinger C, Feichtinger H, Madersbacher S, Berger P (April 1998). "Production of trophoblastic ...
"References: Gestational Trophoblastic Disease". www.cancer.org. 25 June 2012. Retrieved 2020-12-16. "Gestational Trophoblastic ... "Epithelioid trophoblastic tumor", Definitions, Qeios, 2020-02-10, doi:10.32388/ka4bji "Gestational Trophoblastic Neoplasia ... "Gestational Trophoblastic Disease - Diagnosis". Cancer.Net. 2012-06-25. Retrieved 2020-12-16. "Gestational Trophoblastic ... placental site trophoblastic tumor (PSTT) and epithelioid trophoblastic tumor (ETT). The choriocarcinoma has 2 significant ...
"Gestational Trophoblastic Neoplasms" by people in Harvard Catalyst Profiles by year, and whether "Gestational Trophoblastic ... "Gestational Trophoblastic Neoplasms" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, ... Below are the most recent publications written about "Gestational Trophoblastic Neoplasms" by people in Profiles. ... Below are MeSH descriptors whose meaning is more general than "Gestational Trophoblastic Neoplasms". ...
Gestational trophoblastic neoplasia (GTN) is staged by The American Joint Committee on Cancer (AJCC) and the Féderation ... Gestational Trophoblastic Neoplasms. Amin MB, Edge S, Greene F, Byrd DR, Brookland RK, et al, eds. AJCC Cancer Staging Manual. ... Staging and Scoring for Gestational Trophoblastic Neoplasia. Gestational trophoblastic neoplasia (GTN) is staged by the ... encoded search term (Gestational Trophoblastic Tumor Staging) and Gestational Trophoblastic Tumor Staging What to Read Next on ...
Lack of a Y-chromosomal complement in the majority of gestational trophoblastic neoplasms. In: Journal of Oncology. 2010 ; Vol ... Lack of a Y-chromosomal complement in the majority of gestational trophoblastic neoplasms. / Yap, Kai Lee; Hafez, Michael J.; ... Gestational trophoblastic neoplasms (GTNs) are a rare group of neoplastic diseases composed of choriocarcinomas, placental site ... Lack of a Y-chromosomal complement in the majority of gestational trophoblastic neoplasms. Journal of Oncology. 2010;2010: ...
I have expertise in robotic surgery, as well as in treating endometrial cancers and gestational trophoblastic neoplasms. My ...
Gestational trophoblastic neoplasia (GTN) is staged by The American Joint Committee on Cancer (AJCC) and the Féderation ... Gestational Trophoblastic Neoplasms. Amin MB, Edge S, Greene F, Byrd DR, Brookland RK, et al, eds. AJCC Cancer Staging Manual. ... Staging and Scoring for Gestational Trophoblastic Neoplasia. Gestational trophoblastic neoplasia (GTN) is staged by the ... encoded search term (Gestational Trophoblastic Tumor Staging) and Gestational Trophoblastic Tumor Staging What to Read Next on ...
X Germ-cell, trophoblastic and other gonadal neoplasms 101 X(a) Intracranial and intraspinal germ-cell tumors 102 X(b) Other ... III(e) Misc intracranial and intraspinal neoplasms 36 III(f) Unspecified intracranial and intraspinal neoplasm 40 IV ... II Lymphoma and reticuloendothelial neoplasms 21 II(a) Hodgkin lymphoma 22 II(b) Non-Hodgkin lymphoma 23 II(c) Burkitt lymphoma ... III CNS and misc intracranial and intraspinal neoplasms 31 III(a) Ependymoma 32 III(b) Astrocytoma 33 III(c) Primitive ...
It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of ... Trophoblastic Neoplasms (Trophoblastic Tumor) 06/01/2004 - "Floxuridine-containing regimens in the treatment of gestational ... Neoplasms (Cancer) 08/01/1991 - "More importantly, the tumor/liver ratio of FUDR uptake was significantly greater in the HA/A- ... Neoplasm Metastasis (Metastasis) 02/01/1999 - "Improved results with high response rates have been reported after development ...
Gestational Trophoblastic Neoplasms. *Kidney. *Larynx. *Leukemia. *Liver. *Lung. *Lymphoma (Hodgkin and Non-Hodgkin) ...
Malignant trophoblastic neoplasms with different modes of origin.. Arima T et al. ... Gestational and nongestational trophoblastic tumors distinguished by DNA analysis.. Fisher RA et al. ... Genetics and molecular markers in gestational trophoblastic disease with special reference to their clinical application.. ... Combination chemotherapy with methotrexate, etoposide, and actinomycin D for high-risk gestational trophoblastic tumors.. ...
Suppressed follicle-stimulating hormone (FSH) in women with gestational trophoblastic neoplasms. J Clin Endocrinol Metab. 1973 ... A malignant metastatic form of trophoblastic tumors. Unlike the HYDATIDIFORM MOLE, choriocarcinoma contains no CHORIONIC VILLI ... CTLA-4 and p53 gene polymorphism and susceptibility to gestational trophoblastic diseases. J Reprod Med. 2009 Jan; 54(1):25-31. ... Interleukin-18 gene promoter polymorphisms in women with gestational trophoblastic diseases. J Reprod Med. 2008 Nov; 53(11):853 ...
6.2 Germ cell and trophoblastic neoplasms of nongonadal sites. 0.3. 0.3. 0.5. 0.3. 0.1. 0.1. ... 9.2.4 Other specified neoplasms, NOS. -. -. 0.2. 0.7. 6.6. 8.5. 10. UNSPECIFIED MALIGNANT NEOPLASMS. -. -. 0.3. 0.5. 36.1. 25.9 ... 6.1 Germ cell and trophoblastic neoplasms of gonads. 0.2. 0.3. 10.6. 0.7. 3.9. 0.1. ... 6. GERM CELL AND TROPHOBLASTIC NEOPLASMS. 0.5. 0.6. 11.1. 1.1. 4.1. 0.2. ...
Trophoblastic Neoplasms, Pelvic Reconstructive Surgery, Neovagina, Obstetrics and Gynecology ... Cause-specific mortality was evaluated in eligible survivors (n = 568), and subsequent malignant neoplasms, chronic health ... Cause-specific mortality was evaluated in eligible survivors (n = 568), and subsequent malignant neoplasms, chronic health ... Cause-specific mortality was evaluated in eligible survivors (n = 568), and subsequent malignant neoplasms, chronic health ...
... levels comparable to those observed in early pregnancy may also be associated with trophoblastic or nontrophoblastic neoplasms ...
... while the constituent ratio of abortion and trophoblastic diseases, ovarian tumor, uterine and endometrial lesions, was no ... ovarian neoplasms, and uterine and endometrial lesions in daytime and at night (P,0.05), as shown in Figure 1 and Table 3. ... abortion and trophoblastic diseases, which include inevitable abortion, complete abortion, incomplete abortion, missed abortion ... while the constituent ratio of abortion and trophoblastic diseases, ovarian tumor, uterine and endometrial lesions, was no ...
Gestational trophoblastic neoplasm and women living with HIV and/or AIDS. (AOSIS Publishing, 2015-07-03. ) Barnardt, Pieter; ... Managing gestational trophoblastic neoplasm (GTN) and people living with HIV (PLWH). (MedPharm Publications, 2019. ) Barnardt, ... Gestational trophoblastic neoplasm (GTN) is a rare pregnancy-related disorder with an incidence ranging from 0.12-0.7/1000 ... poor performance status and extent of metastatic disease in gestational trophoblastic neoplasm patients receiving chemotherapy ...
Gestational trophoblastic neoplasm. Data from Orphanet are used to provide information on a diseases name, synonym(s), and ... A form of gestational trophoblastic neoplasia similar to a hydatidiform mole but with deep invasion into the myometrium and ...
Gestational Trophoblastic Neoplasms. Gestational Trophoblastic Disease. C23 - Pathological Conditions, Signs and Symptoms. ... C04 - Neoplasms. Gestational Trophoblastic Neoplasms. Gestational Trophoblastic Disease. Sarcoma, Ewings. Sarcoma, Ewing. ...
Gestational Trophoblastic Neoplasms. Gestational Trophoblastic Disease. C23 - Pathological Conditions, Signs and Symptoms. ... C04 - Neoplasms. Gestational Trophoblastic Neoplasms. Gestational Trophoblastic Disease. Sarcoma, Ewings. Sarcoma, Ewing. ...
Gestational Trophoblastic Neoplasms. Gestational Trophoblastic Disease. C23 - Pathological Conditions, Signs and Symptoms. ... C04 - Neoplasms. Gestational Trophoblastic Neoplasms. Gestational Trophoblastic Disease. Sarcoma, Ewings. Sarcoma, Ewing. ...
Gestational Trophoblastic Neoplasms. Gestational Trophoblastic Disease. C23 - Pathological Conditions, Signs and Symptoms. ... C04 - Neoplasms. Gestational Trophoblastic Neoplasms. Gestational Trophoblastic Disease. Sarcoma, Ewings. Sarcoma, Ewing. ...
Gestational Trophoblastic Neoplasms. Gestational Trophoblastic Disease. C23 - Pathological Conditions, Signs and Symptoms. ... C04 - Neoplasms. Gestational Trophoblastic Neoplasms. Gestational Trophoblastic Disease. Sarcoma, Ewings. Sarcoma, Ewing. ...
Gestational Trophoblastic Neoplasms. Gestational Trophoblastic Disease. C23 - Pathological Conditions, Signs and Symptoms. ... C04 - Neoplasms. Gestational Trophoblastic Neoplasms. Gestational Trophoblastic Disease. Sarcoma, Ewings. Sarcoma, Ewing. ...
Gestational Trophoblastic Neoplasms. Gestational Trophoblastic Disease. C23 - Pathological Conditions, Signs and Symptoms. ... C04 - Neoplasms. Gestational Trophoblastic Neoplasms. Gestational Trophoblastic Disease. Sarcoma, Ewings. Sarcoma, Ewing. ...
Gestational Trophoblastic Neoplasms. K. *Kidney. L. *Larynx. *Leukemia. *Liver. *Lung. *Lymphoma (Hodgkin and Non-Hodgkin) ...
Tumors of the uterine corpus and gestational trophoblastic disease. 第一作者值,用於查詢 ...
Gestational trophoblastic disease (GTD) can be benign or malignant. Histologically, it is classified into hydatidiform mole, ... invasive mole (chorioadenoma destruens), choriocarcinoma, and placental site trophoblastic tumor (PSTT). ... The goals of pharmacotherapy are to reduce morbidity and to eradicate the neoplasm. ... Placental site trophoblastic tumors and epithelioid trophoblastic tumors: Biology, natural history, and treatment modalities. ...
Label: childhood kidney neoplasm Synonyms: childhood kidney neoplasm Alternative IDs: als API: GO ...
Trophoblastic Neoplasms Medicine & Life Sciences 52% * Choriocarcinoma Medicine & Life Sciences 22% View full fingerprint ... All met the National Cancer Institute criteria for high-risk gestational trophoblastic tumors. Response was evaluated by ... All met the National Cancer Institute criteria for high-risk gestational trophoblastic tumors. Response was evaluated by ... All met the National Cancer Institute criteria for high-risk gestational trophoblastic tumors. Response was evaluated by ...
  • Benign lesions include placental site nodule and hydatidiform moles while malignant lesions have four subtypes including invasive mole, gestational choriocarcinoma, placental site trophoblastic tumor (PSTT) and epithelioid trophoblastic tumor (ETT). (wikipedia.org)
  • Placental side trophoblastic tumor (PSTT) is differentiated by low β-hCG levels because it is a neoplastic proliferation of intermediate trophoblastic cells. (wikipedia.org)
  • [ 2 ] The modified WHO prognostic scoring system is not applicable to patients with placental-site trophoblastic disease (PSTT) or epithelioid trophoblastic tumor (ETT). (medscape.com)
  • Choriocarcinoma of the ovary is a highly malignant ovarian tumor which is characterized pathologically by the presence of trophoblastic malignant cells, and biochemically by the production of the pregnancy hormone human chorionic gonadotrophin (hCG) in the absence of an ongoing pregnancy. (atlasgeneticsoncology.org)
  • Microscopically, hemorrheage and necrosis are found, and tumor cells resemble placental trophoblastic cells: cytotrophoblast (CT), intermediate trophoblast (IT), and syncytiotrophoblast (ST). The CT and IT tend to grow in clusters and sheets separated by ST. The typical pattern of choriocarcinoma has been called two cell pattern, biphasic-terms that reflect the relatively regular, alternating arrangement of CT and ST in the tumor interspread with intermediate trophoblast. (atlasgeneticsoncology.org)
  • Clinical characteristics and treatment of gestational trophoblastic tumor with vaginal metastasis. (medscape.com)
  • Relapse rate of patients with low-risk gestational trophoblastic tumor initially treated with single-agent chemotherapy. (medscape.com)
  • BACKGROUND: Gestational choriocarcinoma (GC) is a highly malignant trophoblastic tumor that often develops from a complete hydatidiform mole (HM). (bvsalud.org)
  • Here, we investigated the mechanism by which NLRP7 controls these processes in malignant (JEG-3) and non-tumor (HTR8/SVneo) trophoblastic cells. (bvsalud.org)
  • Chromosomes of the neoplasm were studied by the fluorescence in situ hybridization technique and the tumor was found to carry XX chromosomes. (biomedcentral.com)
  • whether the tumor is a primary placental or uterine neoplasm. (biomedcentral.com)
  • It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. (lookformedical.com)
  • Although the most common cause of an elevated HCG level in females is pregnancy, occasionally, a HCG-secreting tumor is suspected and other conditions such as gestational trophoblastic disease (GTD), nontrophoblastic neoplasms, or a pituitary source of HCG, must be considered. (sheppard-arts.com)
  • Gestational trophoblastic neoplasms (GTNs) are a rare group of neoplastic diseases composed of choriocarcinomas, placental site trophoblastic tumors (PSTTs) and epithelioid trophoblastic tumors (ETTs). (johnshopkins.edu)
  • Since these tumors are derivatives of fetal trophoblastic tissue, approximately 50% of GTN cases are expected to originate from a male conceptus and carry a Y-chromosomal complement according to a balanced sex ratio. (johnshopkins.edu)
  • A malignant metastatic form of trophoblastic tumors. (umassmed.edu)
  • Gestational trophoblastic tumors are sensitive to many antineoplastic agents, especially those that act in the S phase or the M phase of the cell cycle. (medscape.com)
  • What is the best protocol of single-agent methotrexate chemotherapy in nonmetastatic or low-risk metastatic gestational trophoblastic tumors? (medscape.com)
  • Roberts JP, Lurain JR. Treatment of low-risk metastatic gestational trophoblastic tumors with single-agent chemotherapy. (medscape.com)
  • To evaluate the efficacy and toxicity of a regimen of etoposide, methotrexate, actinomycin D, cyclophosphamide, and vincristine in patients with metastatic, high-risk gestational trophoblastic tumors. (elsevierpure.com)
  • All met the National Cancer Institute criteria for high-risk gestational trophoblastic tumors. (elsevierpure.com)
  • Performed by an interventional radiologist, selective embolization of the uterine artery is reported as a well-tolerated and effective treatment option for managing severe bleeding from residual uterine vascular malformations in patients with gestational trophoblastic tumors that have been treated. (medscape.com)
  • Neoplasms originating from the blood or bone marrow (leukemias and myeloproliferative disorders) are not considered solid tumors. (mycancergenome.org)
  • Smith HO, Kohorn E, Cole LA. Choriocarcinoma and gestational trophoblastic disease. (medscape.com)
  • Corresponding antigens seem to be expressed on placenta, since the lymphocytotoxic antibodies could be absorbed out with trophoblastic homogenates and one serum reacted with JAR cells (cultured choriocarcinoma line). (ox.ac.uk)
  • The elevated HCG levels are also associated with trophoblastic diseases and certain nontrophoblastic neoplasms. (artronlab.com)
  • A number of conditions other than pregnancy including trophoblastic disease and certain nontrophoblastic neoplasms cause elevated levels of hCG. (mydiscountpill.com)
  • Stage I - Disease confined to the uterus Stage II - GTN extends outside of the uterus, but is limited to the genital structures (adnexa, vagina, broad ligament) Stage III - GTN extends to the lungs, with or without known genital tract involvement Stage IV - All other metastatic sites All types of gestational trophoblastic neoplasia originate from the placenta. (wikipedia.org)
  • The response to treatment is generally favourable but the associated complications of HIV, comorbidities, poor performance status and extent of metastatic disease in gestational trophoblastic neoplasm patients receiving chemotherapy, compromises the outcome and survival. (sun.ac.za)
  • 5-day methotrexate for women with metastatic gestational trophoblastic disease. (medscape.com)
  • Conclusions: Chemotherapy with etoposide, methotrexate, actinomycin D, cyclophosphamide, and vincristine is well tolerated and highly effective for metastatic, high-risk gestational trophoblastic disease. (elsevierpure.com)
  • Neoplasms, Germ Cell and Embryonal" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (sdsu.edu)
  • This graph shows the total number of publications written about "Neoplasms, Germ Cell and Embryonal" by people in this website by year, and whether "Neoplasms, Germ Cell and Embryonal" was a major or minor topic of these publications. (sdsu.edu)
  • Below are the most recent publications written about "Neoplasms, Germ Cell and Embryonal" by people in Profiles. (sdsu.edu)
  • A form of gestational trophoblastic neoplasia similar to a hydatidiform mole but with deep invasion into the myometrium and histologically characterized by hyperplasia of trophoblasts generalized cystic degeneration of chorionic villi and the presence of molar villi in the myometrium and/ or uterine blood vessels. (globalgenes.org)
  • Gestational trophoblastic neoplasia (GTN) is group of rare diseases related to pregnancy and included in gestational trophoblastic disease (GTD) in which abnormal trophoblast cells grow in the uterus. (wikipedia.org)
  • Gestational trophoblastic neoplasm (GTN) is a rare pregnancy-related disorder with an incidence ranging from 0.12-0.7/1000 pregnancies in Western nations. (sun.ac.za)
  • However, elevated hCG levels are frequently associated with trophoblastic and non-trophoblastic neoplasms and hence these conditions should be considered before a diagnosis of pregnancy can be made. (hematologyanalyzerreagent.com)
  • A case report of effusion cytology of a mucinous neoplasm is illustrated. (sun.ac.za)
  • A primary malignant neoplasm of epithelial liver cells. (lookformedical.com)
  • Representative examples include epithelial neoplasms (e.g. lung carcinoma, prostate carcinoma, breast carcinoma, colon carcinoma), and neoplasms arising from the soft tissues and bones (e.g. leiomyosarcoma, liposarcoma, chondrosarcoma, osteosarcoma). (mycancergenome.org)
  • Kashef MA, Dehaghani AS, Naeimi S, Fattahi MJ, Ghaderi A. Interleukin-18 gene promoter polymorphisms in women with gestational trophoblastic diseases. (umassmed.edu)
  • Gestational trophoblastic neoplasia (GTN) represents a spectrum of premalignant and malignant diseases that occur after abnormal fertilization. (medscape.com)
  • Renal metastases of gestational trophoblastic disease: a report of eight cases. (medscape.com)
  • Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. (lookformedical.com)
  • Management of liver metastasis from gestational trophoblastic neoplasia. (medscape.com)
  • Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms. (lookformedical.com)
  • Gestational trophoblastic neoplasia (GTN) is staged by the American Joint Committee on Cancer (AJCC) and the Féderation Internationale de Gynécologie et d'Obstétrique (FIGO) systems, based on the criteria below (see Table 1). (medscape.com)
  • Current FIGO staging for cancer of the vagina, fallopian tube, ovary, and gestational trophoblastic neoplasia. (medscape.com)
  • To describe the prevalence of inadequate nutritional status of children and adolescents with malignant neoplasm at hospital admission in childhood cancer reference centers in Brazil. (bvsalud.org)
  • I have expertise in robotic surgery, as well as in treating endometrial cancers and gestational trophoblastic neoplasms. (rochester.edu)
  • Heterozygous/dispermic complete mole confers a significantly higher risk for post-molar gestational trophoblastic disease. (cdc.gov)
  • It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract. (curehunter.com)
  • Liver neoplasms. (lookformedical.com)
  • Is lack of response to single-agent chemotherapy in gestational trophoblastic disease associated with dose scheduling or chemotherapy resistance? (medscape.com)
  • Lymphocytotoxic antibodies reacting with husband's lymphocytes were demonstrated in 24 sera from women with trophoblastic neoplasia studied before any chemotherapy. (ox.ac.uk)
  • Neoplasms composed of primordial GERM CELLS of embryonic GONADS or of elements of the germ layers of the EMBRYO, MAMMALIAN. (sdsu.edu)
  • The concept does not refer to neoplasms located in the gonads or present in an embryo or FETUS. (sdsu.edu)
  • Patients who did not undergo full colonoscopy preoperatively should undergo colonoscopy within 3-6 months postoperatively to exclude other synchronous colorectal neoplasms and 1 year thereafter. (health.am)
  • Characterization of antibodies reacting with husband's lymphocytes in sera from patients with trophoblastic malignancies. (ox.ac.uk)
  • An enhancing role of such antibodies in the growth of trophoblastic malignancies may be suggested. (ox.ac.uk)
  • Rapid escalation of weekly intramuscular methotrexate for nonmetastatic gestational trophoblastic disease: a Gynecologic Oncology Group study. (medscape.com)
  • HCG is a hormone produced by trophoblastic tissue and it appears around the 8-9th day after ovulation, or around the 4th day after conception. (artronlab.com)
  • Serologic studies of embryonic and trophoblastic tissues of the mouse. (jax.org)
  • A benign or malignant neoplasm arising from tissues that do not include fluid areas. (mycancergenome.org)
  • Gestational Trophoblastic Disease: Current Evaluation and Management. (medscape.com)
  • This is called persistent trophoblastic disease. (sheppard-arts.com)
  • Neoplasms containing cyst-like formations or producing mucin or serum. (lookformedical.com)
  • These neoplasms have varying propensities for invasion and spread. (harvard.edu)
  • It is useful in malignant forms of gestational trophoblastic neoplasia (GTN) to characterize the degree of myometrial and/or parametrial invasion and to assess the treatment response. (medscape.com)