Lesion of the subthalamic nucleus for the alleviation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced...
Lesion of the subthalamic nucleus for the alleviation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced ... Lesion of the subthalamic nucleus for the alleviation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced ...
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride - Cascade Chemistry
Brain structural changes in cynomolgus monkeys administered with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: A longitudinal...
Y1 - 2018/1. N2 - In animal models of Parkinsons disease (PD), 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is one of ... In animal models of Parkinsons disease (PD), 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is one of the most widely ... AB - In animal models of Parkinsons disease (PD), 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is one of the most ... Dive into the research topics of Brain structural changes in cynomolgus monkeys administered with 1-methyl-4-phenyl-1,2,3,6- ...
Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model...
Thus, drinking H2-containing water may be useful in daily life to prevent or minimize the risk of life style-related oxidative ... 4, No. 9, e7247, 30.09.2009.. Research output: Contribution to journal › Article › peer-review ... 1,2,3,6 Tetrahydro 1 Methyl 4 Phenylpyridine Pharmacology, Toxicology and Pharmaceutical Science 50% ... It has been shown that molecular hydrogen (H2) acts as a therapeutic antioxidant and suppresses brain injury by buffering the ...
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) disrupts social memory/recognition processes in the male mouse. · NEOMED...
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) disrupts social memory/recognition processes in the male mouse.. Title. 1- ... Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) disrupts social memory/recognition processes in the male mouse. ... Social Behavior, 1-Methyl-4-phenyl-1, 1993, 2, 3, 6-tetrahydropyridine/*analogs & derivatives/pharmacology, Animals, Brain ... Social Behavior; 1-Methyl-4-phenyl-1; 2; 3; 6-tetrahydropyridine/*analogs & derivatives/pharmacology; Animals; Brain Chemistry/ ...
Dietary supplementation of walnut partially reverses 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine induced neurodegeneration...
في: Neurochemical Research, المجلد 40, رقم 6, 2015, صفحة 1283-1293.. نتاج البحث: المساهمة في مجلة › Article › مراجعة النظراء ... Dietary supplementation of walnut partially reverses 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine induced neurodegeneration ... Dietary supplementation of walnut partially reverses 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine induced neurodegeneration ... Dietary supplementation of walnut partially reverses 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine induced neurodegeneration ...
MPTP - Wikipedia
Tetrahydropyridines, Phenyl compounds). ... It is classified as a tetrahydropyridine. It is of interest as ... Retrieved 3 September 2023. "Success reported using fetal tissue to repair a brain". The New York Times. 26 November 1992. "How ... 88 (1): 193-201. doi:10.1093/toxsci/kfi304. PMID 16141438. Langston, J. W. (2002). "Chapter 30 The Impact of MPTP on ... 1 (3): 249-254. doi:10.1016/0165-1781(79)90006-4. PMID 298352. S2CID 44304872. "Bogus Heroin Brings Illness on the Coast". The ...
Mitochondrial DNA and Parkinson disease. Methodologic review]
1 Groupe dEtudes et de Recherches sur le Muscle et le Nerf, EA 2347, Université Paris XII, Faculté de Médecine, Créteil. ... Our aim was to answer the following questions: (1) are there some abnormalities of mtDNA in PD? (2) if there are some, what are ... these abnormalities? and (3) what is the pathogenic role of these abnormalities? ...
Monoamine Oxidase - MAO Summary Report | CureHunter
Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP) 9. Dopamine Agonists (Dopamine Agonist) ... 1. Parkinson Disease (Parkinsons Disease) 01/01/2000 - "On the other hand, inhibition of MAO B appears to be an effective ... 3. Body Weight (Weight, Body) 03/01/2008 - "Goutengsan could increase the brain index, cut down the rate of death, stable ... 4. Schizophrenia (Dementia Praecox) 05/01/1978 - "MAO activity, csf amine metabolites, and drug-free improvement in ...
Parkinson disease - Symptoms, diagnosis and treatment | BMJ Best Practice US
Prosaposin maintains lipid homeostasis in dopamine neurons and counteracts experimental parkinsonism in rodents | Nature...
Overexpression of PSAP via AAV and encapsulated cell biodelivery protected against 6-OHDA and α-synuclein toxicity in wild-type ... 4: cPSAPDAT mice are more vulnerable to AAV-α-synuclein-induced toxicity, while AAV-PSAP intranigral injection counteracts the ... 2: cPSAPDAT mice show reduced levels of dopaminergic markers and behavioral deficiencies, while cPSAPSERT mice behave normally. ... NWT = 13, NcPSAPSERT = 11 in (S-W). Scale bars, 200 μm (A, E), 1 mm (C),and 20 μm (H). Data are presented as mean ± S.E.M. ...
Erowid.org: Erowid Reference 6182 : 3,4-Methylenedioxymethamphetamine (Ecstasy) Inhibits Dyskinesia Expression and Normalizes...
Jenner P 3,4-Methylenedioxymethamphetamine (Ecstasy) Inhibits Dyskinesia Expression and Normalizes Motor Activity in 1-Methyl-4 ... Phenyl-1,2,3,6-Tetrahydropyridine-Treated Primates The Journal of Neuroscience 2003 23(27):9107-9115 ... Ecstasy [3,4-methylenedioxymethamphetamine (MDMA)] was shown to prolong the action of L-3,4-dihydroxyphenylalanine (L-DOPA) ... In 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated, L-DOPA-primedcommonmarmosets,MDMAtransiently relieved motor ...
European Journal of Neuroscience
A presynaptic N-methyl-D-aspartate autoreceptor in rat hippocampus modulating amino acid release from a cytoplasmic pool. Eur J ... A possible role of the N ‐methyl‐ d ‐aspartate receptor (NMDA‐R) as a presynaptic autoreceptor was investigated using Percoll‐ ... The extent of protection was similar to that observed with the nonselective mGlu receptor antagonist (+)-alpha-methyl-4- ... Persistent suppression of N-methyl-d-aspartate (NMDA) receptor function produces enduring structural changes in neocortical and ...
Frontiers | Dopamine signaling negatively regulates striatal phosphorylation of Cdk5 at tyrosine 15 in mice
Moreover, in the 1-methyl-4-phenyl-1,2,4,6-tetrahydropyridine (MPTP) mouse model, dopamine deficiency caused increased ... Moreover, in the 1-methyl-4-phenyl-1,2,4,6-tetrahydropyridine mouse model, dopamine deficiency caused increased phosphorylation ... 4-dihydroxyphenylalanine and imatinib (STI-571), a selective c-Abl inhibitor. Our results suggest a functional link of Cdk5- ... 4-dihydroxyphenylalanine and imatinib (STI-571), a selective c-Abl inhibitor. Our results suggest a functional link of Cdk5- ...
Front Matter | Nonhuman Primate Models in Biomedical Research: State of the Science and Future Needs | The National Academies...
3 CURRENT LANDSCAPE OF USE AND AVAILABILITY OF NONHUMAN PRIMATES FOR NIH-SUPPORTED BIOMEDICAL RESEARCH ... 4 The Landscape of New Approach Methodologies 113-146 * 5 Future Needs and Opportunities for Nonhuman Primate Models in ... COMMITTEE ON THE STATE OF THE SCIENCE AND FUTURE NEEDS FOR NONHUMAN PRIMATE MODEL SYSTEMS1. KENNETH S. RAMOS (Chair), Alkek ... B-2 Tissue Archiving and Sharing Practice at National Resources. FIGURES. 1-1 Leading causes of death in the United States, ...
Apraxia of Lid Opening: Background, Pathophysiology, Etiology
3, 4, 5, 6, 7] ALO may present either in isolation or in association with blepharospasm. [8, 9, 10] The challenge for ... 1, 15, 23, 29] :. * Lithium - Lithium intoxication resulted in development of ALO; on withdrawal of lithium, symptoms may remit ... 2] Nevertheless, the designation ALO does address the main feature of the condition-namely, the inability to open the eyes at ... 1] Controversy surrounds the designation of this syndrome. Strictly speaking, ALO is not truly an apraxia or "inability to ...
Molecules | Free Full-Text | The Lactoferrin Phenomenon—A Miracle Molecule
1. Introduction. Throughout life, from birth to old age, the human body is exposed to a myriad of harmful factors such as ... PLoS Genet. 2007, 3, e220. [Google Scholar] [CrossRef]. *Cardoso, A.L.; Fernandes, A.; Aguilar-Pimentel, J.A.; De Angelis, M.H ... 3. Conclusions. Lactoferrin is a multifunctional protein derived from milk with high affinity for iron ions. It is known that ... It is also known that too strong an antioxidant response may not be beneficial [3] as in the case of high-dose vitamin E ...
Changes of D1 and D2 dopamine receptor mRNA in the brains of monkeys lesioned with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine...
The effect of L-3,4-dihydroxyphenylalanine (L-DOPA) on dopamine receptor gene expression in the brain of 1-methyl-4-phenyl-1,2, ... Changes of D1 and D2 dopamine receptor mRNA in the brains of monkeys lesioned with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine ... Changes of D1 and D2 dopamine receptor mRNA in the brains of monkeys lesioned with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine ... Changes of D1 and D2 dopamine receptor mRNA in the brains of monkeys lesioned with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine ...
Valina L. Dawson - Publications
Reduction of functional N-methyl-D-aspartate receptors in neurons by RNase P-mediated cleavage of the NR1 mRNA. Journal of ... Nitric oxide mediates N-methyl-D-aspartate receptor-induced activation of p21ras. Proceedings of the National Academy of ... 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.01881 0.8. 2020. Jia L, Liu Y, Wang W, Wang Y, Liu H, Liu F, Chen R, Dawson VL, Dawson ... 3: 1089-95. PMID 9334719 DOI: 10.1038/Nm1097-1089 0.537. 1997. Demas GE, Eliasson MJ, Dawson TM, Dawson VL, Kriegsfeld LJ, ...
Levodopa-induced dyskinesia: Mechanisms and management | British Columbia Medical Journal
4, May, 2001, Page(s) 206-209 - Clinical Articles.. Above is the information needed to cite this article in your paper or ... 4, May, 2001, Page(s) 206-209 - Clinical Articles.. Above is the information needed to cite this article in your paper or ... 1. Marsden CD, Parkes JD, Quinn N. Fluctuations of disability in Parkinsons disease-clinical aspects. In: Marsden CD, Fahn, S ... 6. Jenner P. Factors influencing the onset and persistence of dyskinesia in MPTP-treated primates. Ann Neurol 2000;47: S90-9; ...
Erowid.org: Erowid Reference 273 : More about parkinsonism after taking ecstasy : Sewell RA, Cozzi NV
hypothesized that their patient had parkinsonism as a result of a delayed neurotoxic effect of 3,4- ... on his basal ganglia and noted that his condition most closely resembled nigrostriatal damage induced by 1-methyl-4-phenyl-1,2, ...
Animal models of Parkinson's disease: an empirical comparison with the phenomenology of the disease in man
1 Department of Clinical Neurochemistry, University Neurological Clinic, University of Würzburg, Federal Republic of Germany. ... The partial elucidation of the processes underlie the selective action of neurotoxic substances such as 6-hydroxydopamine (6- ... or 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), has however revealed possible molecular mechanisms that give rise to ... experimentally-induced degeneration of nigrostriatal dopaminergic neurons with 6-OHDA, methamphetamine, MPTP, MPP+, ...
<em>In Silico</em> Studies in Predicting Mechanism of Action of Amaranthus tricolor on...
... and N-methyl-Daspartate (NMDA) receptor antagonist memantine (Namenda) [4]. However, these agents lose effectiveness as the ... 6. 4. 2.49. 0.77. Hepatotoxicity. Boropinic acid. 1.10E+07. C15 H18 O4. 262.12. 4. 1. 4.05. -0.41. Cardiac failure, myocardial ... 2. Activation of MAPK activity. 0.0278. GO:0007166. ADORA2A, APP, KDR, KIT, MAOA. 5. Cell surface receptor signaling pathway. ... 3. Regulation of synaptic plasticity. 0.0039. GO:0048169. APP, KIT. 2. Regulation of long-term neuronal synaptic plasticity. ...
Erowid.org: Erowid Reference 481 : 'Designer drugs'. A problem in clinical toxicology : Buchanan JF, Brown CR
A problem in clinical toxicology Med Toxicol Adverse Drug Exp 1988 3(1):1-17 ... 1988;3(1):1-17.. Buchanan JF, Brown CR. "Designer drugs. A problem in clinical toxicology" Med Toxicol Adverse Drug Exp. 1988 ... Attempts to synthesise pethidine have resulted in the accidental production of MPTP (1-methyl-4-phenyl-1,2,3,6- ... tetrahydropyridine), a compound which is metabolised in the brain by the monoamine oxidase system to a toxic intermediate (MPP+ ...
Determination of ER stress in the experimental 6-OHDA rat model of Parkinson´s disease
Two weeks after 6-OHDA lesions, amphetamine-induced rotation test was conducted to the rats. The rats were divided into groups ... The aim of this study was to characterize ER stress in 6-OHDA rat model. The expression of some key mediators of the UPR were ... Determination of ER stress in the experimental 6-OHDA rat model of Parkinson´s disease. Show simple item record ... For this study, the rats were euthanised at week 2 or week 4 post lesion. The rats were euthanised by carbondioxide, and the ...
SISIUS: Ficha personal: Lin Gao Chen
N m. 1-3. Pag. 256-260 Keeling, Km, Lanier, J, Du, M, Salas Marco, J, Gao Chen, Lin, et. al.:. Leaky Termination At Premature ... N m. 4. Pag. 281-284. 10.1016/j.parkreldis.2010.12.013 Gao Chen, Lin, Diaz Martin, Juan, Dillmann, W, Lopez Barneo, Jose:. Heat ... N m. 1. Pag. 41-45 Romero Ruiz, Antonio, Mejias Estevez, Rebeca Maria, Diaz Martin, Juan, Lopez Barneo, Jose, Gao Chen, Lin:. ... N m. 1. Pag. 145-158. 10.1016/j.cmet.2018.05.009 Ortega Saenz, Gracia Patricia, Caballero Eraso, Candelaria, Gao Chen, Lin:. ...
WikiGenes - Metabolism
The 3--,5 exonucleases of DNA polymerases delta and epsilon and the 5--,3 exonuclease Exo1 have major roles in ... Metabolic effect of 3,3,5-triiodothyronine in cultured growth hormone-producing rat pituitary tumor cells. Evidence for a ... Local cerebral metabolic effects of L-dopa therapy in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in ... In this study we characterized the metabolic effects of dichloroacetate in a human model of peripheral muscle ischemia [4]. ...
Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism |...
The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective ... However, oltipraz as well as the CDDO-derivative, bardoxolone methyl, because of serious side effects reported in some trials, ... 3. The role of SKN-1 in the development of C. elegans. In the early embryo skn-1 mRNA is deposited in both cells: AB and P1, ... like BEACON-bardoxolone methyl evaluation in patients with chronic kidney disease and type 2 diabetes (ClinicalTrials.gov, ...
Can the Flu and Other Viruses Cause Neurodegeneration? | The Scientist Magazine®
Judes biosafety level 3 lab, he and his colleagues infected ducks with the virus, then sacrificed the birds and removed their ... A. Ogata et al., "A rat model of Parkinsons disease induced by Japanese encephalitis virus," J Neurovirol, 3:141-47, 1997. ... One of the virus strains that induced MS symptoms in mice was herpesvirus 6, which has also been associated with the ... In the 1940s and early 1950s, diagnoses of the neurodegenerative disease appeared to increase abruptly, from 1-2 percent of the ...
PRIME PubMed | Small molecule TrkB agonist deoxygedunin protects nigrostriatal dopaminergic neurons from 6-OHDA and MPTP...
Small molecule TrkB agonist deoxygedunin protects nigrostriatal dopaminergic neurons from 6-OHDA and MPTP induced neurotoxicity ... 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAnimalsCorpus StriatumDopaminergic NeuronsLimoninsMaleMice, Inbred C57BLMotor ... Mice were given deoxygedunin 5 mg/kg (i.p.) for 2 weeks and administrated with MPTP twice at the dose of 20 mg/kg (i.p.) on day ... Mice were given deoxygedunin 5 mg/kg (i.p.) for 2 weeks and administrated with MPTP twice at the dose of 20 mg/kg (i.p.) on day ...