2',3'-Cyclic-Nucleotide Phosphodiesterases | Profiles RNS
Cyclic-Nucleotide Phosphodiesterases" by people in Profiles.. * Kaliyaperumal S, W?thrich C, Westmoreland SV, Koralnik IJ. ... Cyclic-Nucleotide Phosphodiesterases" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, ... Cyclic-Nucleotide Phosphodiesterases" by people in this website by year, and whether "2,3-Cyclic-Nucleotide ... cyclic nucleotides. Also hydrolyzes nucleoside monophosphates. Includes EC 3.1.4.16 and EC 3.1.4.37. EC 3.1.4.-. ...
PDB 4WEX | Chain CATALYTIC DOMAIN OF MOUSE 2',3'-CYCLIC NUCLEOTIDE 3'- PHOSPHODIESTERASE, WITH MUTATION Y168S | 4WEX A | 3D...
CYCLIC NUCLEOTIDE 3- PHOSPHODIESTERASE, WITH MUTATION Y168S - 4WEX , canSARS ... CATALYTIC DOMAIN OF MOUSE 2,3-CYCLIC NUCLEOTIDE 3- PHOSPHODIESTERASE, WITH MUTATION Y168S ... CATALYTIC DOMAIN OF MOUSE 2,3-CYCLIC NUCLEOTIDE 3- PHOSPHODIESTERASE, WITH MUTATION Y168S ...
Intrinsic Sleep Disorders - Ontology Report - Rat Genome Database
... cyclic nucleotide 3 phosphodiesterase. ISO. protein:decreased expression:brain. RGD. PMID:21570342. RGD:6483334. NCBI chrNW_ ... cysteinyl leukotriene receptor 2. ISO. protein:increased expression:tonsil, T cell. RGD. PMID:18490405. RGD:4888517. NCBI chrNW ... ataxin 3. ISO. RGD. PMID:15128861. RGD:1358427. NCBI chrNW_004955438:14,405,415...14,443,457 Ensembl chrNW_004955438:14,405,643 ... nuclear receptor subfamily 3 group C member 1. ISO. mRNA, protein:increased expression:lymphoid tissue:. RGD. PMID:15611350. ...
Cnpase Antikörper, ELISA Kits
cyclic nucleotide phosphodiesterase 1. *CNP2. *2,3-cyclic nucleotide 3 phosphodiesterase. *cyclic-CMP phosphodiesterase ... cyclic nucleotide 3 phosphodiesterase (cnp.L), CNP, cnp, Cnp-1, CNP1, Cnp1, CNPase, CNPF, CNPI, CNPII, cnpl, DKFZp469F1421, ... cyclic nucleotide 3 phosphodiesterase (CNP), 2,3-cyclic nucleotide 3 phosphodiesterase (Cnp), 2,3-cyclic nucleotide 3 ... 354, Issue 2, pp. 175-83, (2015) (PubMed). Kandadai, Mok, Ali, Li: "Characterization of an RNA-cleaving deoxyribozyme with ...
phosphodiesterase 5A | Phosphodiesterases, 3',5'-cyclic nucleotide (PDEs) | IUPHAR/BPS Guide to PHARMACOLOGY
... cyclic nucleotide (PDEs). Detailed annotation on the structure, function, physiology, pharmacology and clinical relevance of ... 2000) Phosphorylation of phosphodiesterase-5 by cyclic nucleotide-dependent protein kinase alters its catalytic and allosteric ... 1999) Inhibition of cyclic GMP-binding cyclic GMP-specific phosphodiesterase (Type 5) by sildenafil and related compounds. Mol ... cGMP-binding cGMP specific phosphodiesterase 5A2 , PDE5A2 , PDE5A1 , phosphodiesterase 5A, cGMP-specific ...
CPD1 | SGD
Cyclic nucleotide PhosphoDiesterase 1 Comparative Info. Sequence Details Sequence The S. cerevisiae Reference Genome sequence ... Cyclic nucleotide phosphodiesterase; hydrolyzes ADP-ribose 1, 2-cyclic phosphate to ADP-ribose 1-phosphate; may have a ... Cyclic nucleotide phosphodiesterase that hydrolyzes nucleoside 2,3 cyclic phosphodiester bond to yield nucleoside 2- ...
BindingDB BDBM14390 5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d...
... cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human)). Plexxikon. Ligand. BDBM14390(5-[2-ethoxy-5-(4-methyl-1- ... cyclic nucleotide phosphodiesterase 1A/1B(Bos taurus). Bayer AG. Curated by ChEMBL. ... cyclic nucleotide phosphodiesterase 1A/1B(Bos taurus). Bayer AG. Curated by ChEMBL. ... cyclic nucleotide phosphodiesterase 1B/Dual specificity calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase ...
Clopidogrel-Induced Neutropenia after Coronary Stenting: Is Cilostazol a Good Alternative?
Cilostazol is an antiplatelet that selectively inhibits cyclic nucleotide phosphodiesterase type 3 (PDE III) [13] and is ... 1,2Italo Porto. ,1,2,3Antonella Gallo. ,1,2Claudia Camaioni. ,1,2Roberta Della Bona. ,1,2Antonio Grieco. ,1,2Filippo Crea. ,1,2 ... thus increasing the cyclic AMP (cAMP) content of human platelets. Additionally, cilostazol has another important ... 2. Case Report. A 65-year old Caucasian male was admitted to the Department of Internal Medicine of our Hospital for the sudden ...
NMDAR1 autoantibodies amplify behavioral phenotypes of genetic white matter inflammation: a mild encephalitis model with...
... cyclic nucleotide 3′-phosphodiesterase (Cnp) with a "cocktail" of NMDAR1 peptides. Cnp−/− mice exhibit early low-grade ... phosphodiesterase) is among the oligodendrocyte/myelin-associated genes most robustly reduced on mRNA and protein level in ... cyclic nucleotide 3′-phosphodiesterase (Cnp), which is causal of progressive, genetically induced white matter inflammation [43 ... 2) Oligodendroglial NR1 cKO cohorts: Female CnpCre+/−:NR1flox/flox (cKO, n = 16) mice and their NR1flox/flox (n = 16) ...
Sodium Nitroprusside inhibits HEK293 Cell Growth by cGMP-Dependent and Independent Mechanisms
Francis, S.H., Sekhar, K.R., Ke, H. and Corbin, J.D. (2011) Inhibition of Cyclic Nucleotide Phosphodiesterases by ... The interaction with the non-selective PDE (cyclic nucleotide phosphodiesterase) inhibitor 3-isobutyl-1-methylxanthine (IBMX) ... Chen, Z.S., Lee, K. and Kruh, G.D. (2001) Transport of Cyclic Nucleotides and Estradiol 17-Beta-d-glucuronide by Multidrug ... Schultz, C., Vaskinn, S., Kildalsen, H. and Sager, G. (1998) Cyclic AMP Stimulates the Cyclic GMP Egression Pump in Human ...
Plus it
... cyclic-nucleotide 3′-phosphodiesterase (CNP) and MBP indicates the degree of OL differentiation in the cultures, as these are ... Data represent the mean ± SEM (n = 3-4). *p , 0.05; **p , 0.01 (E, I, Students t test; G, K, two-way ANOVA with Bonferroni ... 4B). At DIV3, MAG+ve Ilk−/− OLs were predominantly Stage 1, whereas MAG+ve Ilkfl/fl OLs were largely Stage 3 (Fig. 4C). At DIV6 ... 2A,B). Accordingly, fewer Ilk−/− OLs expressed MAG or MBP as compared to wild-type (Ilkfl/fl) cells. However, a certain ...
WikiGenes - EDC4 - enhancer of mRNA decapping 4
... cyclic nucleotide 3 phosphodiesterase as major autoantigen and C3 complement-binding protein in the pathogenesis of multiple ... phosphodiesterase as major autoantigen and C3 complement-binding protein in the pathogenesis of multiple sclerosis [16]. ... The neuronal RNA-binding protein Nova-2 is implicated as the autoantigen targeted in POMA patients with dementia. Yang, Y.Y., ... Bcl-2-dependent oxidation of pyruvate dehydrogenase-E2, a primary biliary cirrhosis autoantigen, during apoptosis. Odin, J.A., ...
Assignment of the 1H, 13C and 15N resonances of the catalytic domain of the rat 2',3'-cyclic nucleotide 3'-phosphodiesterase -...
13C and 15N resonances of the catalytic domain of the rat 2,3-cyclic nucleotide 3-phosphodiesterase ... cyclic nucleotide 3-phosphodiesterase. From National Research Council Canada. Assignment of the 1H, 13C and 15N resonances of ... cyclic nucleotide 3-phosphodiesterase. DOI. Resolve DOI: https://doi.org/10.1023/A:1013898222817. ... Assignment of the 1H, 13C and 15N resonances of the catalytic domain of the rat 2,3- ...
Erection-stimulating, anti-diabetic and antioxidant properties of Hunteria umbellata and Cylicodiscus gabunensis water...
... phosphodiesterase-5 (IC 50 =539.72 µg/mL); arginase (41.53 µg/mL)] than CG [phosphodiesterase-5 (IC 50 =611.35 µg/mL); arginase ... Also, both extracts inhibited phosphodiesterase-5 and arginase in a dose-dependent manner in vitro ; nevertheless, HU showed ... arginase and phosphodiesterase-5) and type-2 diabetes (α-amylase and α-glucosidase) were determined. Antioxidant properties of ... Conclusions The ability of samples extract to inhibit some of key enzymes relevant to erectile dysfunction and type-2 diabetes ...
SCOPe 2.04: Family d.110.2.1: GAF domain
... cyclic nucleotide phosphodiesterase 2A, GAF A and GAF B domains [82760] (1 species). GAF B is the nucleotide binding domain; ... core: 2 alpha-helices and 5-stranded antiparallel sheet: order 21543; 3 layers: alpha/beta/alpha. ... Sensor protein CYB2465 [160659] (2 species). *. Species Synechococcus sp. [TaxId:1131] [160660] (4 PDB entries). Uniprot Q2JIZ5 ... automated matches [227076] (2 species). not a true protein. *. Species Deinococcus radiodurans [TaxId:1299] [226274] (5 PDB ...
The major TMEM106B dementia risk allele affects TMEM106B protein levels, fibril formation, and myelin lipid homeostasis in the...
Cyclic nucleotide 3-phosphodiesterase; MAG: Myelin-associated glycoprotein; MBP: Myelin basic protein; MOG: Myelin- ... phosphodiesterase. DHRS7:. Dehydrogenase/reductase 7. ERLIN2:. ER lipid raft associated 2 ... Linkage disequilibrium analysis for rs1990622 single-nucleotide polymorphism (SNP). Linkage disequilibrium between rs1990622 ... amino acid and nucleotide metabolism, and oxidative phosphorylation were increased (Fig. 1C and D). Proteins that were ...
DiVA - Search result
... stimulation or to inhibition of cyclic nucleotide phosphodiesterase (PDE). The inactive analogue LY-303511 did not induce ... stimulation or to inhibition of cyclic nucleotide phosphodiesterase (PDE). The inactive analogue LY-303511 did not induce ... Regulatory importance of cyclic nucleotides in smooth muscle growth of the urogenital tract. Adolfsson, Per ... Regulatory importance of cyclic nucleotides in smooth muscle growth of the urogenital tract2001Doctoral thesis, comprehensive ...
Frontiers | The Role of PDE11A4 in Social Isolation-Induced Changes in Intracellular Signaling and Neuroinflammation
... an enzyme that degrades cyclic nucleotides (cAMP and cGMP), is the only PDE whose mRNA expression in brain is restricted to the ... an enzyme that degrades cyclic nucleotides (cAMP and cGMP), is the only PDE whose mRNA expression in brain is restricted to the ... 2) if isolation-induced decreases occur uniquely in adults (i.e., not adolescents), and 3) how the loss of PDE11 signaling may ... 2) if isolation-induced decreases occur uniquely in adults (i.e., not adolescents), and 3) how the loss of PDE11 signaling may ...
Journal of Veterinary Medical Science
Effects of Various Selective Phosphodiesterase Inhibitors on Carbachol-induced Contraction and Cyclic Nucleotide Contents in ... Effects of various selective phosphodiesterase (PDE) inhibitors on muscle contractility and cyclic nucleotide contents in ... The effects of cyclic AMP increasing cardiotonics (dopamine, dobutamine, amrinone and milrinone) on the blood flow in most ... we could not find any nucleotide differences in both cDNAs between KK and C57BL/6J strains.. ...
TOP
This is probably an artifactual activity; recall that the biologically active cyclic nucleotides are those with a 3′:5′ ... phosphodiesterase. There are many higher molecular weight proteins present in the gel-electrophoretic pattern of myelin. These ... cyclic nucleotide-3′-phosphodiesterase (CNP), which comprises several percent of myelin protein [23]. Although there are low ... cyclic cytidine monophosphate (cCMP) and cyclic uridine monophosphate (cUMP) analogs, all of which are hydrolyzed to the ...
Profiles RNS
... cyclic nucleotide 3-phosphodiesterase in myelin lipid rafts. Glia. 2008 Jan 1; 56(1):118-33.View Related Profiles.. Peters, ... 2007 Oct; 55(2):256-63. PMID: 17270274; PMCID: PMC3593595; DOI: 10.1016/j.brainresrev.2006.12.002; ... 2009 Apr; 123(2):231-41.View Related Profiles.. Peters, Alan. Rosene, Douglas. Moss, Mark. Killiany, Ronald. Moore, Tara. ... Luebke JI, Medalla M, Amatrudo JM, Weaver CM, Crimins JL, Hunt B, Hof PR, Peters A. Age-related changes to layer 3 pyramidal ...
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Montelukast reduces grey matter abnormalities and functional deficits in a mouse model of inflammation-induced encephalopathy...
The lowest effective dose, 3 mg/kg, was able to improve anxiety and spatial learning deficits in this model of ... Cyclic-nucleotide 3-phosphodiesterase. CysLTs:. Cysteinyl leukotrienes. CysLTR:. Cysteinyl leukotriene receptor. d:. Diffusion ... 3B, D). The average MD in the cortex of saline-treated animals was 3.9 × 10-4 ± 0.01 × 10-4 mm2/s, which increased to 4.1 × 10- ... 2C). In contrast to the findings in the cortex, no significant alteration in the number of PV+ interneurons was found in the ...
The plasticity of primary microglia and their multifaceted effects on endogenous neural stem cells in vitro and in vivo |...
... cyclic-nucleotide 3′-phosphodiesterase (CNPase); clone 11-5B, dilution 1:500, Cat# MAB326, RRID:AB_2082608, Millipore, ... phosphodiesterase" (CNPase; green), identifying oligodendrocytes, with Hoechst (blue) as nuclear counterstain; scale bar = 20 ... 3. Switch between microglia phenotypes. *p , 0.05, **p , 0.01, ***p , 0.001 compared to control; #p , 0.05, ##p , 0.01, ###p , ... 2. Functional changes in polarized microglia. * p , 0.05, **p , 0.01, *** p , 0.001 compared to control; ##p , 0.01, ###p , ...
Isolation, cloning and characterization of a putative type-1 astrocyte cell line<...
Cyclic-Nucleotide Phosphodiesterases Medicine & Life Sciences 68% * Cell Line Medicine & Life Sciences 64% ...
ArgR: Streptomycetaceae
... cyclic-nucleotide 2-phosphodiesterase (EC 3.1.4.16) *. Streptomyces coelicolor A3(2) Site: position = -178. score = 3.59679 ... phosphodiesterase (EC 3.1.4.16) Streptomyces griseus subsp. griseus NBRC 13350 Gene: SGR_5514: 2,3-cyclic-nucleotide 2- ... 2. Streptomyces griseus subsp. griseus NBRC 13350 Site: position = -27. score = 5.06639 sequence = TCATGCATAAGAATGCATAC. Site: ... 2. Streptomyces griseus subsp. griseus NBRC 13350 Site: position = -57. score = 3.79471 sequence = CTTTGCATAAAAGTGCGCCG. Site: ...
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... cyclic phosphodiesterase-like hydrolase 42.49 597 aa 373 1e-102 Kytococcus sedentarius DSM 20547 Bacteria normal 0.593719 ... cyclic nucleotide 2-phosphodiesterase/3-nucleotidase precursor protein 26.08 1202 aa 152 2e-35 Clostridium perfringens SM101 ... Escherichia coli SMS-3-5 Bacteria normal 1 normal 0.693263 -. NC_009523 RoseRS_0843 5-nucleotidase domain-containing protein ... Escherichia coli SMS-3-5 Bacteria normal 1 normal 1 -. NC_008530 LGAS_1067 5-nucleotidase/2,3-cyclic phosphodiesterase ...
Novel oligodendroglial alpha synuclein viral vector models of multiple system atrophy: studies in rodents and nonhuman primates...
Histological analysis 3-months after injection demonstrated widespread α-syn expression throughout the striatum as determined ... cyclic nucleotide 3′-phosphodiesterase (CNP) [67], have been developed to study MSA. The resulting tg mouse lines developed ... phosphodiesterase (CNP) promoter [67]. Initial studies using PLP-driven expression reported formation of GCIs, however ... 3. α-Syn Expression in NHPs Following injection of Olig001-α-syn. Representative a LB509 and b phosphorylated serine-129 ...
Bio2Vec
Genetically induced brain inflammation by Cnp deletion transiently benefits from microglia depletion :: MPG.PuRe
... cyclic nucleotide 3′-phosphodiesterase (Cnp) in humans and mice causes white matter inflammation and catatonic signs. These ... 1 treatment alone, 2) the correlation of catatonic signs and executive dysfunction, 3) the phenotype of leftover microglia ... Importantly, 2 extended rounds of CSF1R inhibition are not superior to 1 treatment regarding any readout investigated (magnetic ... Here we address for the first time preclinical topics crucial for translation, most importantly 1) the comparison of 2 long- ...