Nov 2003). "Structural evidence that brain cyclic nucleotide phosphodiesterase is a member of the 2H phosphodiesterase ... selectively activates the calcium-calmodulin sensitive isoform of cyclic nucleotide phosphodiesterase from human myometrium". ... "Purification to homogeneity and general properties of a novel phosphodiesterase hydrolyzing cyclic CMP and cyclic AMP". The ... "A homogeneous cyclic CMP phosphodiesterase hydrolyzes both pyrimidine and purine cyclic 2:3- and 3:5-nucleotides". The ...
Cyclic-Nucleotide Phosphodiesterases" by people in Profiles.. * Kaliyaperumal S, W?thrich C, Westmoreland SV, Koralnik IJ. ... Cyclic-Nucleotide Phosphodiesterases" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, ... Cyclic-Nucleotide Phosphodiesterases" by people in this website by year, and whether "2,3-Cyclic-Nucleotide ... cyclic nucleotides. Also hydrolyzes nucleoside monophosphates. Includes EC 3.1.4.16 and EC 3.1.4.37. EC 3.1.4.-. ...
CYCLIC NUCLEOTIDE 3- PHOSPHODIESTERASE, WITH MUTATION Y168S - 4WEX , canSARS ... CATALYTIC DOMAIN OF MOUSE 2,3-CYCLIC NUCLEOTIDE 3- PHOSPHODIESTERASE, WITH MUTATION Y168S ... CATALYTIC DOMAIN OF MOUSE 2,3-CYCLIC NUCLEOTIDE 3- PHOSPHODIESTERASE, WITH MUTATION Y168S ...
... cyclic nucleotide 3 phosphodiesterase. ISO. protein:decreased expression:brain. RGD. PMID:21570342. RGD:6483334. NCBI chrNW_ ... cysteinyl leukotriene receptor 2. ISO. protein:increased expression:tonsil, T cell. RGD. PMID:18490405. RGD:4888517. NCBI chrNW ... ataxin 3. ISO. RGD. PMID:15128861. RGD:1358427. NCBI chrNW_004955438:14,405,415...14,443,457 Ensembl chrNW_004955438:14,405,643 ... nuclear receptor subfamily 3 group C member 1. ISO. mRNA, protein:increased expression:lymphoid tissue:. RGD. PMID:15611350. ...
cyclic nucleotide phosphodiesterase 1. *CNP2. *2,3-cyclic nucleotide 3 phosphodiesterase. *cyclic-CMP phosphodiesterase ... cyclic nucleotide 3 phosphodiesterase (cnp.L), CNP, cnp, Cnp-1, CNP1, Cnp1, CNPase, CNPF, CNPI, CNPII, cnpl, DKFZp469F1421, ... cyclic nucleotide 3 phosphodiesterase (CNP), 2,3-cyclic nucleotide 3 phosphodiesterase (Cnp), 2,3-cyclic nucleotide 3 ... 354, Issue 2, pp. 175-83, (2015) (PubMed). Kandadai, Mok, Ali, Li: "Characterization of an RNA-cleaving deoxyribozyme with ...
... cyclic nucleotide (PDEs). Detailed annotation on the structure, function, physiology, pharmacology and clinical relevance of ... 2000) Phosphorylation of phosphodiesterase-5 by cyclic nucleotide-dependent protein kinase alters its catalytic and allosteric ... 1999) Inhibition of cyclic GMP-binding cyclic GMP-specific phosphodiesterase (Type 5) by sildenafil and related compounds. Mol ... cGMP-binding cGMP specific phosphodiesterase 5A2 , PDE5A2 , PDE5A1 , phosphodiesterase 5A, cGMP-specific ...
Cyclic nucleotide PhosphoDiesterase 1 Comparative Info. Sequence Details Sequence The S. cerevisiae Reference Genome sequence ... Cyclic nucleotide phosphodiesterase; hydrolyzes ADP-ribose 1, 2-cyclic phosphate to ADP-ribose 1-phosphate; may have a ... Cyclic nucleotide phosphodiesterase that hydrolyzes nucleoside 2,3 cyclic phosphodiester bond to yield nucleoside 2- ...
Francis, S.H., Sekhar, K.R., Ke, H. and Corbin, J.D. (2011) Inhibition of Cyclic Nucleotide Phosphodiesterases by ... The interaction with the non-selective PDE (cyclic nucleotide phosphodiesterase) inhibitor 3-isobutyl-1-methylxanthine (IBMX) ... Chen, Z.S., Lee, K. and Kruh, G.D. (2001) Transport of Cyclic Nucleotides and Estradiol 17-Beta-d-glucuronide by Multidrug ... Schultz, C., Vaskinn, S., Kildalsen, H. and Sager, G. (1998) Cyclic AMP Stimulates the Cyclic GMP Egression Pump in Human ...
Cyclic-Nucleotide 3′-phosphodiesterase (CNPase) and Myelin Oligodendrocyte Glycoprotein (MOG) (Fig. 2E,F and Suppl. Fig. 2A,B ... phosphodiesterase, MOG Myelin Oligodendrocyte Glycoprotein. *P , 0.05; **P , 0.01; ***P , 0.001; ****P , 0.0001. ... Figure 3. JNK1 loss increases OPC proliferation and alters OPC territory and architecture in vivo. (A) Distribution of PDGFRα+ ... Figure 2. Myelin alterations in JNK1 KO are not related to axonal abundance. (A) MBP+ (red) and SMI31 neurofilaments (green) ...
... cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human)). Plexxikon. Ligand. BDBM14390(5-[2-ethoxy-5-(4-methyl-1- ... cyclic nucleotide phosphodiesterase 1A/1B(Bos taurus). Bayer AG. Curated by ChEMBL. ... cyclic nucleotide phosphodiesterase 1A/1B(Bos taurus). Bayer AG. Curated by ChEMBL. ... cyclic nucleotide phosphodiesterase 1B/Dual specificity calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase ...
Cilostazol is an antiplatelet that selectively inhibits cyclic nucleotide phosphodiesterase type 3 (PDE III) [13] and is ... 1,2Italo Porto. ,1,2,3Antonella Gallo. ,1,2Claudia Camaioni. ,1,2Roberta Della Bona. ,1,2Antonio Grieco. ,1,2Filippo Crea. ,1,2 ... thus increasing the cyclic AMP (cAMP) content of human platelets. Additionally, cilostazol has another important ... 2. Case Report. A 65-year old Caucasian male was admitted to the Department of Internal Medicine of our Hospital for the sudden ...
... cyclic-nucleotide 3′-phosphodiesterase (CNP) and MBP indicates the degree of OL differentiation in the cultures, as these are ... Data represent the mean ± SEM (n = 3-4). *p , 0.05; **p , 0.01 (E, I, Students t test; G, K, two-way ANOVA with Bonferroni ... 4B). At DIV3, MAG+ve Ilk−/− OLs were predominantly Stage 1, whereas MAG+ve Ilkfl/fl OLs were largely Stage 3 (Fig. 4C). At DIV6 ... 2A,B). Accordingly, fewer Ilk−/− OLs expressed MAG or MBP as compared to wild-type (Ilkfl/fl) cells. However, a certain ...
... cyclic nucleotide 3 phosphodiesterase as major autoantigen and C3 complement-binding protein in the pathogenesis of multiple ... phosphodiesterase as major autoantigen and C3 complement-binding protein in the pathogenesis of multiple sclerosis [16]. ... The neuronal RNA-binding protein Nova-2 is implicated as the autoantigen targeted in POMA patients with dementia. Yang, Y.Y., ... Bcl-2-dependent oxidation of pyruvate dehydrogenase-E2, a primary biliary cirrhosis autoantigen, during apoptosis. Odin, J.A., ...
... phosphodiesterase-5 (IC 50 =539.72 µg/mL); arginase (41.53 µg/mL)] than CG [phosphodiesterase-5 (IC 50 =611.35 µg/mL); arginase ... Also, both extracts inhibited phosphodiesterase-5 and arginase in a dose-dependent manner in vitro ; nevertheless, HU showed ... arginase and phosphodiesterase-5) and type-2 diabetes (α-amylase and α-glucosidase) were determined. Antioxidant properties of ... Conclusions The ability of samples extract to inhibit some of key enzymes relevant to erectile dysfunction and type-2 diabetes ...
13C and 15N resonances of the catalytic domain of the rat 2,3-cyclic nucleotide 3-phosphodiesterase ... cyclic nucleotide 3-phosphodiesterase. From National Research Council Canada. Assignment of the 1H, 13C and 15N resonances of ... cyclic nucleotide 3-phosphodiesterase. DOI. Resolve DOI: https://doi.org/10.1023/A:1013898222817. ... Assignment of the 1H, 13C and 15N resonances of the catalytic domain of the rat 2,3- ...
... cyclic nucleotide phosphodiesterase 2A, GAF A and GAF B domains [82760] (1 species). GAF B is the nucleotide binding domain; ... core: 2 alpha-helices and 5-stranded antiparallel sheet: order 21543; 3 layers: alpha/beta/alpha. ... Sensor protein CYB2465 [160659] (2 species). *. Species Synechococcus sp. [TaxId:1131] [160660] (4 PDB entries). Uniprot Q2JIZ5 ... automated matches [227076] (2 species). not a true protein. *. Species Deinococcus radiodurans [TaxId:1299] [226274] (5 PDB ...
... an enzyme that degrades cyclic nucleotides (cAMP and cGMP), is the only PDE whose mRNA expression in brain is restricted to the ... an enzyme that degrades cyclic nucleotides (cAMP and cGMP), is the only PDE whose mRNA expression in brain is restricted to the ... 2) if isolation-induced decreases occur uniquely in adults (i.e., not adolescents), and 3) how the loss of PDE11 signaling may ... 2) if isolation-induced decreases occur uniquely in adults (i.e., not adolescents), and 3) how the loss of PDE11 signaling may ...
Cyclic nucleotide 3-phosphodiesterase; MAG: Myelin-associated glycoprotein; MBP: Myelin basic protein; MOG: Myelin- ... phosphodiesterase. DHRS7:. Dehydrogenase/reductase 7. ERLIN2:. ER lipid raft associated 2 ... Linkage disequilibrium analysis for rs1990622 single-nucleotide polymorphism (SNP). Linkage disequilibrium between rs1990622 ... amino acid and nucleotide metabolism, and oxidative phosphorylation were increased (Fig. 1C and D). Proteins that were ...
Effects of Various Selective Phosphodiesterase Inhibitors on Carbachol-induced Contraction and Cyclic Nucleotide Contents in ... Effects of various selective phosphodiesterase (PDE) inhibitors on muscle contractility and cyclic nucleotide contents in ... The effects of cyclic AMP increasing cardiotonics (dopamine, dobutamine, amrinone and milrinone) on the blood flow in most ... we could not find any nucleotide differences in both cDNAs between KK and C57BL/6J strains.. ...
... stimulation or to inhibition of cyclic nucleotide phosphodiesterase (PDE). The inactive analogue LY-303511 did not induce ... stimulation or to inhibition of cyclic nucleotide phosphodiesterase (PDE). The inactive analogue LY-303511 did not induce ... Regulatory importance of cyclic nucleotides in smooth muscle growth of the urogenital tract. Adolfsson, Per ... Regulatory importance of cyclic nucleotides in smooth muscle growth of the urogenital tract2001Doctoral thesis, comprehensive ...
Cyclic-Nucleotide Phosphodiesterases 2,3-Didehydro-3-deoxythymidine use Stavudine 2,3-Dideoxy-3-thiacytidine use ... 2-Fluoro-2-deoxyglucose use Fluorodeoxyglucose F18 2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10- ... 2-Amino-5-phosphonovaleric Acid use 2-Amino-5-phosphonovalerate 2-Amino-6-(1,2,3-trihydroxypropyl)-4(3H)-pteridinone use ... 3-Deoxyarabinoheptulosonate-7-Phosphate Synthetase use 3-Deoxy-7-Phosphoheptulonate Synthase 3 End Processing, RNA use RNA 3 ...
Cyclic-Nucleotide Phosphodiesterases 2,3-Didehydro-3-deoxythymidine use Stavudine 2,3-Dideoxy-3-thiacytidine use ... 2-Amino-5-phosphonovaleric Acid use 2-Amino-5-phosphonovalerate 2-Amino-6-(1,2,3-trihydroxypropyl)-4(3H)-pteridinone use ... 2-Dehydro-3-Deoxyphosphoheptonate Aldolase use 3-Deoxy-7-Phosphoheptulonate Synthase 2-Fluoro-2-deoxy-D-glucose use ... 2,6-Dichlorophenolindophenol use 2,6-Dichloroindophenol 3 beta-Hydroxy-delta-5-Steroid Dehydrogenase use Progesterone Reductase ...
Cyclic-Nucleotide Phosphodiesterases 2,3-Didehydro-3-deoxythymidine use Stavudine 2,3-Dideoxy-3-thiacytidine use ... 2-Fluoro-2-deoxyglucose use Fluorodeoxyglucose F18 2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10- ... 2-Amino-5-phosphonovaleric Acid use 2-Amino-5-phosphonovalerate 2-Amino-6-(1,2,3-trihydroxypropyl)-4(3H)-pteridinone use ... 3-Deoxyarabinoheptulosonate-7-Phosphate Synthetase use 3-Deoxy-7-Phosphoheptulonate Synthase 3 End Processing, RNA use RNA 3 ...
Cyclic-Nucleotide Phosphodiesterase use 3,5-Cyclic-AMP Phosphodiesterases. 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific) ... 3-Keto-5-alpha-Steroid delta-4-Dehydrogenase use Testosterone 5-alpha-Reductase ... 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester ... 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer ...
Cyclic-Nucleotide Phosphodiesterases 2,3-Didehydro-3-deoxythymidine use Stavudine 2,3-Dideoxy-3-thiacytidine use ... 2-Fluoro-2-deoxyglucose use Fluorodeoxyglucose F18 2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10- ... 2-Amino-5-phosphonovaleric Acid use 2-Amino-5-phosphonovalerate 2-Amino-6-(1,2,3-trihydroxypropyl)-4(3H)-pteridinone use ... 3-Deoxyarabinoheptulosonate-7-Phosphate Synthetase use 3-Deoxy-7-Phosphoheptulonate Synthase 3 End Processing, RNA use RNA 3 ...
Cyclic-Nucleotide Phosphodiesterases 2,3-Didehydro-3-deoxythymidine use Stavudine 2,3-Dideoxy-3-thiacytidine use ... 2-Amino-5-phosphonovaleric Acid use 2-Amino-5-phosphonovalerate 2-Amino-6-(1,2,3-trihydroxypropyl)-4(3H)-pteridinone use ... 2-Dehydro-3-Deoxyphosphoheptonate Aldolase use 3-Deoxy-7-Phosphoheptulonate Synthase 2-Fluoro-2-deoxy-D-Glucose use ... 2,6-Dichlorophenolindophenol use 2,6-Dichloroindophenol 3 beta-Hydroxy-delta-5-Steroid Dehydrogenase use Progesterone Reductase ...
Cyclic-Nucleotide Phosphodiesterases 2,3-Didehydro-3-deoxythymidine use Stavudine 2,3-Dideoxy-3-thiacytidine use ... 2-Amino-5-phosphonovaleric Acid use 2-Amino-5-phosphonovalerate 2-Amino-6-(1,2,3-trihydroxypropyl)-4(3H)-pteridinone use ... 2-Dehydro-3-Deoxyphosphoheptonate Aldolase use 3-Deoxy-7-Phosphoheptulonate Synthase 2-Fluoro-2-deoxy-D-Glucose use ... 2,6-Dichlorophenolindophenol use 2,6-Dichloroindophenol 3 beta-Hydroxy-delta-5-Steroid Dehydrogenase use Progesterone Reductase ...
Cyclic-Nucleotide Phosphodiesterase use 3,5-Cyclic-AMP Phosphodiesterases. 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific) ... 3-Keto-5-alpha-Steroid delta-4-Dehydrogenase use Testosterone 5-alpha-Reductase ... 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester ... 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer ...
Cyclic-Nucleotide Phosphodiesterases 2,3-Didehydro-3-deoxythymidine use Stavudine 2,3-Dideoxy-3-thiacytidine use ... 2-Amino-5-phosphonovaleric Acid use 2-Amino-5-phosphonovalerate 2-Amino-6-(1,2,3-trihydroxypropyl)-4(3H)-pteridinone use ... 2-Dehydro-3-Deoxyphosphoheptonate Aldolase use 3-Deoxy-7-Phosphoheptulonate Synthase 2-Fluoro-2-deoxy-D-Glucose use ... 2,6-Dichlorophenolindophenol use 2,6-Dichloroindophenol 3 beta-Hydroxy-delta-5-Steroid Dehydrogenase use Progesterone Reductase ...