4-Nitroquinoline 1-oxide (also known as 4-NQO, 4NQO, 4Nqo, NQO and NQNO) is a quinoline derivative and a tumorigenic compound ... 28 (4): 409-21. doi:10.1101/gad.228940.113. PMC 3937518. PMID 24532717. Fry, Rebecca C.; Begley, Thomas J.; Samson, Leona D. ( ... 4-nitroquinoline 1-oxide (4NQO) is a quinoline, a carcinogenic and mutagenic chemical. Quinolines, like 4NQO, possess a ... 4 (9): 1169-73. doi:10.1093/carcin/4.9.1169. PMID 6883639. Ikenaga, Mituo; Ichikawa-Ryo, Haruko; Kondo, Sohei (1975). "The ...
Nitroquinoline-N-oxide reductase. In enzymology, a nitroquinoline-N-oxide reductase (EC 1.7.1.9) is an enzyme that catalyzes ... nitroquinoline-N-oxide reductase] EC 1.6.6.11: Now EC 1.7.1.10, ... S-oxide reductase EC 1.8.4.13: L-methionine (S)-S-oxide ... IIDNAOxidesGlutathione TransferaseNitric Oxide Synthase Type IIINitric Oxide Synthase Type IPyridinesNitrogen OxidesZinc Oxide ... oxide reductase EC 1.7.2.4: nitrous-oxide reductase EC 1.7.2.5: nitric oxide reductase (cytochrome c) EC 1.7. ... S-oxide ...
4-nitroquinoline 1-oxide. Definition / meaning of 4-nitroquinoline 1-oxide. A substance that is used in cancer research to ...
107-21-1) and formic acid (CAS No. 64-18-6): In vitro gene mutation in bacteria: negative with and without metabolic activation ... Effects of pH: The pH value was measured in Experiment 1 and 2 (7.58 and 7.56) and thus represented no problem to the Ames Test ... other: 2-Aminoanthracene (2AA; 1, 2 and 10 µg/plate, +S9, TA100, TA1535 and TA1537, WP2uvrA, respectively); Benzo(a)pyrene (BP ... 4-Nitroquinoline-1-oxide (4NQO; 0.2 µg/plate, -S9, TA98). Untreated negative controls:. yes. Negative solvent / vehicle ...
Experiment 1. All of the plates were incubated at 37ºC for approximately 48 hours and scored for the presence of revertant ... 1. A dose-related increase in mutant frequency over the dose range tested (De Serres and Shelby, 1979).. 2. A reproducible ... 4. Biological relevance against in-house historical control ranges.. A test item is considered non-mutagenic (negative) in the ... See table 1 and 2. Vehicle controls validity:. valid. Untreated negative controls validity:. valid. Positive controls validity: ...
... quinoline N-oxide + H2O + 2 NADP(+) <=> 4-nitroquinoline N-oxide + 2 H(+) + 2 NADPH ... quinoline N-oxide + H2O + 2 NAD(+) <=> 4-nitroquinoline N-oxide + 2 H(+) + 2 NADH ... All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.7.1.-. All ENZYME / UniProtKB/Swiss-Prot entries corresponding to ...
1Lin Peng. ,1Vicki Weidenbacher-Hoper. ,2Shixin Deng. ,3Gary Anderson. ,1and Brett J. West. 3 ... A 1 : 1 gender ratio was maintained in each group, with mean ages ranging from 37 to 43 yr. The average number of cigarettes ... Samples were centrifuged and diluted 1 : 10 with deionized water. The diluted samples (10 μL) were mixed with 800 μL deionized ... Table 4 Phytochemical compositions (mean ± standard deviation) of the noni juice product and placebo evaluated in the clinical ...
Chemical/Drug : 4-nitroquinoline-1-oxide (4NQO) • Propylene glycol Tumor Synonyms. esophagus hyperplasia • markedly ... Tang XH, Clin Cancer Res 2004 Jan 1;10(1 Pt 1):301-13 ... Tang XH, Clin Cancer Res 2004 Jan 1;10(1 Pt 1):301-13 ...
References: Hendler FJ, 1996;():79-87 ⋅ Yuan B, Mol Carcinog 1997 May;19(1):8-16 ⋅ Yuan B, Oncogene 1997 Sep 4;15(10):1161-70 ... References: Sundberg J, MGI Direct Data Submission 2007;(): ⋅ Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1(): ⋅ Tillmann T ... References: Berndt A, Cancer Res 2011 Sep 1;71(17):5779-91 ⋅ Sundberg J, MGI Direct Data Submission 2007;(): ⋅ Sundberg JP, ... References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1(): ⋅ Tillmann T, Exp Toxicol Pathol 2000 Jun;52(3):221-5 ...
CD-1. Details on species / strain selection:. Out-bred CD-1 mice (Crl:CD1(ICR)). Sex:. male. Details on test animals or test ... Experiment 1: 3+21h without S-9; 3+21h with S-9; 24+24h without S-9. Experiment 2: 3+21h without S-9; 3+21h with S-9; 24+24h ... Reference 1. Endpoint:. in vitro gene mutation study in mammalian cells. Remarks:. Type of genotoxicity: gene mutation. Type of ... Experiment 1: 3+21h without S-9; 3+21h with S-9; 24+24h without S-9. Experiment 2:3+21h with S-9.. - Expression time (cells in ...
1. Sulser GF, Brening RH, Fosdick LS. Some conditions that affect the odor concentration of the breath. J Dent Res 1939; 18:355 ... CDA members can find out about our complete list of fees and services by contacting us at 1-800-267-6354 or (613) 523-1770, ext ... 4. Kaizu T. [Halitosis, its etiology and prevention]. Nippon Shika Ishikai Zasshi 1976; 29:228-35. Japanese. ... Scores from 1 to 3 are borderline, but some patients may still be diagnosed as having a psychological condition because of ...
FIGURE 4. Figure 4. HSC-3 xenograft-induced change in orofacial nociceptive behavior was measured in adult nude male (A) and ... Nicole N. Scheff1 Robel G. Alemu2 Richard Klares III1 Ian M. Wall2 Stephen C. Yang2 John C. Dolan1 Brian L. Schmidt1* ... FIGURE 1. Figure 1. Recombinant granulocyte colony stimulating factor (rG-CSF)-mediated mobilization of neutrophils was ... Mice were inoculated with 1 × 105 HSC-3 cells in 30 μL of 1:1 DMEM and Matrigel into the anterior lateral portion of the tongue ...
mice were treated with 4-Nitroquinoline N-oxide (4NQO) in drinking water for 11-13 weeks, followed by normal water for 11-12 ... GPR68, or ovarian cancer G protein-coupled receptor 1, responds to extracellular acidity and is highly expressed in head and ...
Bradykinin B2 receptor knockout mice are protected from thrombosis by increased nitric oxide and prostacyclin. Shariat-Madar, Z ... Neonatal end-stage renal failure associated with maternal ingestion of cyclo-oxygenase-type-1 selective inhibitor nimesulide as ... Acceleration of atherogenesis by COX-1-dependent prostanoid formation in low density lipoprotein receptor knockout mice. ... Increased expression of cyclooxygenase-2 protein in 4-nitroquinoline-1-oxide-induced rat tongue carcinomas and chemopreventive ...
Concepts are listed by decreasing relevance which is based on many factors, including how many publications the person wrote about that topic, how long ago those publications were written, and how many publications other people have written on that same topic ...
... inhibits the TORC1 kinase signaling pathway causing rapid alteration in gene expression and ultimately cell cycle arrest in G 1 ... Rapamycin induces G1 arrest in the H2B WT, but not in the H2B R95A mutant-When WT cells are challenged with α-factor, the ... 7A, lanes 1 to 4 and quantified as in Fig. 7B, and supplementary Fig. S3), but not to the same extent as the ste5Δ mutant. ... 1(2): p. 132-6.. *Schmitt, M.E., T.A. Brown, and B.L. Trumpower, A rapid and simple method for preparation of RNA from ...
P. 1-7 ERDA-TR-263 KIRILLIN, V. A. //DOKLADY AKADEMIYA NAUK SSSR/l 00/00/1%9,VO185,NO002, PP 0316-0319 EXPLOSIVELY DRIVEN MHO ... 1;1 KIPELAINEN, H. //PAPERI JU PUU// OO/OO/1974,VOO5f6,N----, PP 0702-0704 DIMESION CHANGES OF PLYWOOD AS A FUNCTION OF 0 ... VIRUSOL// 00/00/1%7,V----,NO001, PP 0145-0146 AN INDUCED CHANGE IN THE TYPE CHARACTERISTICS OF FOOT~AND-MOUTH DISEASE VIRUS * ... 1. STUDIES ON GERMINATION OF BARLEY SEEDS 216 PP NRCC C 22020 KIRIBUCHI, S. //DENPUN KOGYO GAKKAISHI/l 00/00/1974,VO021,NO004, ...
... On-line free medical diagnosis assistant. Ranked list of possible diseases from either several symptoms or a full patient history. A similarity measure between symptoms and diseases is provided.
4 (2015) * Elena Lo Piparo, Lydia Siragusa, Frederic Raymond, Giovanna I. Passeri, Gabriele Cruciani, Benoît Schilter, ... The lowest effective concentration of the genotoxin 4-nitroquinoline-1-oxide (0.53 nM; 20 pg/band) in the SOS-Umu-C assay was ... ILSI Europe Report Series, 1-70. Oda, Y. (2016). Development and progress for three decades in umu test systems. Genes Environ ... doi:10.1556/1006.2019.32.3.1 Veyrand, J., Marin-Kuan, M. and Bezencon, C. et al. (2017). Integrating bioassays and analytical ...
Yeh, C. F., Li, W. Y., Chu, P. Y., Kao, S. Y., Chen, Y. W., Lee, T. L., Hsu, Y. B., Yang, C. C. & Tai, S. K., 1 Oct 2016, In: ... Lin, Y. C., Lin, Y. H., Lo, M. T., Peng, C. K., Huang, N. E., Yang, C. C. H. & Kuo, T. B. J., 1 Feb 2016, In: Chaos. 26, 2, ... Kao, S. Y., Tsai, M. M., Wu, C. H., Chen, J. J., Tseng, S. H., Lin, S. C. & Chang, K. W., 1 Apr 2016, In: Head and Neck. 38, 4 ... Yang, C. C., Tu, H. F., Wu, C. H., Chang, H. C., Chiang, W. F., Shih, N. C., Lee, Y. S., Kao, S. Y. & Chang, K. W., 1 May 2016 ...
Heterocyclic Oxides [D03.661] * Cyclic N-Oxides [D03.661.243] * 4-Hydroxyaminoquinoline-1-oxide [D03.661.243.320] ... Cyclic N-Oxides (1972-1974). Hydroxylamines (1974). Quinolines (1972-1974). Public MeSH Note. 91; was see under AMINOQUINOLINES ... 4-Hydroxyaminoquinoline-1-oxide Preferred Term Term UI T044125. Date01/01/1999. LexicalTag NON. ThesaurusID NLM (1975). ... 4-Hydroxyaminoquinoline-N-oxide Term UI T044126. Date11/11/1974. LexicalTag NON. ThesaurusID UNK (19XX). ...
Only D4-Ro 47-8634 had a more pronounced effect on bosentan metabolism. Apparent Ki values were 6.6 μM on the formation of Ro ... The apparent terminal half-life (T1/2) was estimated from the terminal rate constant λz with t1/2 = ln2/λz (λz was determined ... 1. Plasma concentration-time profiles in rats of bosentan alone and in combination with cyclosporin A or verapamil. Rats (n = 5 ... Experiments with D4-Ro 47-8634 were performed at inhibitor concentrations of 10, 30, and 100 μM, whereas D4-Ro 48-5033 was used ...
1. Incidence, characteristics, risk factors and outcomes of diabetic ketoacidosis in COVID-19 patients: Comparison with ... Type 1 diabetes, steroid therapy for COVID-19, COVID-19 status, black race and male gender were associated with increased risk ... The optimal combination of measures was RAI and day 1 uNGAL, giving an AUC of 0â 80 for severe AKI prediction (95% CI 0â 71, 0â ... This model employs 4-nitroquinoline-1-oxide (4NQO) as an RS-inducing agent. Upon drinking 4NQO-containing water, Brca1 ...
Alteration of cell-mediated immunity in the mouse following administration of 4-nitroquinoline 1-oxide. ...
Grape seed extract and resveratrol prevent 4-nitroquinoline 1-oxide induced oral tumorigenesis in mice by modulating AMPK ...
response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine + ...
Other DNA-damaging agents such as bleomycin or 4-nitroquinoline 1-oxide also caused the nick translation rate to increase. When ... Other DNA-damaging agents such as bleomycin or 4-nitroquinoline 1-oxide also caused the nick translation rate to increase. When ... Other DNA-damaging agents such as bleomycin or 4-nitroquinoline 1-oxide also caused the nick translation rate to increase. When ... Other DNA-damaging agents such as bleomycin or 4-nitroquinoline 1-oxide also caused the nick translation rate to increase. When ...
His Chromatin and Methylnitronitrosoguanidine study in the realm of Biochemistry connects with subjects such as Fowl and 4- ... Nitroquinoline 1-oxide.. His most cited work include:. *A simple technique for quantitation of low levels of DNA damage in ...
produced higher levels of nitric oxide, nuclear factor (NF)-. κ. B, cytokines (e.g., interleukin-1β and tumor necrosis factor-α ... 1. Weissella cibaria. Weissella. is a newly separated lactic acid bacteria of lactobacillus family that was identified by a ... species are shown in Table 1.33. W. cibaria. , newly named by Bjorkroth and others, has been separated from Korean kimchi and ... The total number of deaths due to cancer in 2012 was 267,221, which was increased by 9,825 (3.8%) compared to 2011.1 This was ...