Effect of 6-Aminonicotinamide and Other Protein Synthesis Inhibitors on Formation of Platinum-DNA Adducts and Cisplatin...
Effect of 6-Aminonicotinamide and Other Protein Synthesis Inhibitors on Formation of Platinum-DNA Adducts and Cisplatin ... Effect of 6-Aminonicotinamide and Other Protein Synthesis Inhibitors on Formation of Platinum-DNA Adducts and Cisplatin ... Effect of 6-Aminonicotinamide and Other Protein Synthesis Inhibitors on Formation of Platinum-DNA Adducts and Cisplatin ... Effect of 6-Aminonicotinamide and Other Protein Synthesis Inhibitors on Formation of Platinum-DNA Adducts and Cisplatin ...
Substance Information - ECHA
Effects of neonatal treatment with 6-aminonicotinamide on basal and isoproterenol-stimulated ornithine decarboxylase activity...
6-Aminonicotinamide (6-AN) is a nicotinic acid (vitamin B3) antagonist which, when administered to immature animals, has a ... When given to neonatal rats, 6-aminonicotinamide (10 mg/kg, i.p., on days 1, 3, 5 and 7) caused a prompt and persistent ... Morris, G., Nadler, J. V., Nemeroff, C. B., & Slotkin, T. A. (1985). Effects of neonatal treatment with 6-aminonicotinamide on ... Assessment of cerebellar morphology indicated an early adverse effect of 6-AN on granule cell division, resulting in eventual ...
Tumor metabolome - Wikipedia
20 (1): 51-6. doi:10.1016/j.gde.2009.10.009. PMC 2822127. PMID 19942427. Dang CV (May 2012). "Links between metabolism and ... January 1998). "6-Aminonicotinamide sensitizes human tumor cell lines to cisplatin". Clinical Cancer Research. 4 (1): 117-30. ... p53 activates hexokinase 2 (HK2) that converts glucose to glucose-6-phosphate (G6P) which enters glycolysis to produce ATP, or ... In preclinical studies, drugs such as 6-amino-nicotinamide (6-AN), which inhibits G6P dehydrogenase, the enzyme that initiates ...
C&L Inventory
Wnt9b MGI Mouse Gene Detail - MGI:1197020 - wingless-type MMTV integration site family, member 9B
Niacin - New World Encyclopedia
The designation vitamin B3, whose chemical formula is C5H4NCOOH (or alternatively, C6H6NO2), also includes the corresponding ... "Behavioral changes in rats and guinea pigs induced by the administration of indole 3-acetic acid and 6-aminonicotinamide." The ... is cleaved and rearranged with the alpha amino group of tryptophan into the 6-membered aromatic heterocycle of niacin by the ... whose chemical formula is C6H6N2O. ...
Therapeutic Targeting of DGKA-Mediated Macropinocytosis Leads to Phospholipid Reprogramming in Tuberous Sclerosis Complex |...
6). These data taken together with our lipidomic analyses indicate that DGKA plays a crucial role maintaining phospholipid ... Cells were seeded in 6-well plates and grown in 1% FBS DMEM overnight. Treatments with ritanserin (10 μmol/L) or EIPA (25 μmol/ ... In addition, the macropinocytosis inhibitor EIPA (6 μmol/L; 48 hours) selectively inhibited the proliferation of Tsc2−/− MEFs ... Autophagy-dependent metabolic reprogramming sensitizes TSC2-deficient cells to the antimetabolite 6-aminonicotinamide ...
Gurcharan Kaur
Volume 6 Issue 3 September 1984 pp 331-336 Effect of 6-Aminonicotinamide on the activity of hexokinase and lactate ... in the activity of hexokinase and lactate dehydrogenase isoenzymes in the three brain regions and heart were studied in the 6- ... Aminonicotinamide-treated rats. Drug administration decreased the particulate hexokinase and lactate dehydrogenase activity, ...
Anti-cancer agents and reactive oxygen species modulators that target cancer cell metabolism
6] N. Wong, D. Ojo, J. Yan, D. Tang. Cancer Lett.356, 184 (2015).10.1016/j.canlet.2014.01.031Search in Google Scholar PubMed ... Med.6, 221 (2014).Search in Google Scholar. [121] A. P. Savitsky, T. Finkel. J. Biol. Chem. 277, 20535 (2002).10.1074/jbc. ... Rep.6, 27458 (2016).10.1038/srep27458Search in Google Scholar. [129] E. Schneider, H. Yamazaki, B. K. Sinha, K. H. Cowan. Br. J ... Rep.6, 25705 (2016).10.1038/srep25705Search in Google Scholar. [87] E. L. Westman, M. J. Canova, J. Radhi, K. Koteva, I. ...
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Monoamine Oxidase - MAO Summary Report | CureHunter
dehydroepiandrosterone | Ligand Activity Charts | IUPHAR/BPS Guide to PHARMACOLOGY
Inhibition of human G6PDH using glucose-6-phosphate as substrate by Lineweaver-Burke plot B 5.05 pKi 8900 nM Ki Bioorg Med Chem ... Inhibition of Trypanosoma brucei G6PDH using glucose-6-phosphate as substrate by Lineweaver-Burke plot B 5.77 pKi 1700 nM Ki ... Glucose-6-phosphate 1-dehydrogenase in Trypanosoma brucei (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5672] [UniProtKB: Q9GRG7 ... Glucose-6-phosphate 1-dehydrogenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5347] [UniProtKB: P11413] ...
Registration Dossier - ECHA
... aminonicotinamide. On Day 29 all dams were subjected to Caesarian section. Referring to the maternal observations, survival of ... Reference 6. Endpoint:. developmental toxicity. Type of information:. read-across from supporting substance (structural ... Beginning on Day 6 and continuing daily through Day 15 of gestation, groups (22-23/group) of pregnant females were given 0, ... Beginning on Day 6 and continuing daily through Day 15 of gestation, groups (22-23/group) of pregnant females were given 0, ...
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Pesquisa | Prevenção e Controle de Câncer
6. Integrated transcriptomics, proteomics and metabolomics-based analysis uncover TAM2-associated glycolysis and pyruvate ... Blockage of the pentose phosphate pathway with the inhibitor 6-aminonicotinamide (6-AN), abolished the effects of HK ... The enzyme from Agrobacterium tumefaciens is a homotetramer allosterically regulated by fructose 6-phosphate and pyruvate. ...
US Patent Application for A METHOD FOR TREATING SWI/SNF COMPLEX-DEFICIENT CANCERS COMPRISING GLUTATHIONE (GSH) METABOLIC...
Tenovin-6 2.513722 5.579114 Terreic acid 88.8751 90.53852 TG003 115.1966 138.6968 TABLE S1-12 Drug WT KO TGF-b RI kinase ... TABLE S1-6 Drug WT KO FTI-276 151.7653 118.2926 Fumagillin 96.42703 82.15807 Fumitremorgin C 90.40506 97.38972 Fumonisin B1 ... 3-6. P to 3-6 Q, Figures S4. -1 B to S4-2 E). BSO treatment decreased the GSH level, which was associated with increased ROS ... 6-1. A to 6-1 B). Consistently, tumor weight was reduced by APR-246 only in TOV21G xenografts (. FIGS. 6-1. C to 6-1 D). ...
CDC Science Clips
The suitability of glioblastoma cell lines as models for primary glioblastoma cell metabolism | Research Square
GBM cell lines (U87MG, U118MG, U251MG, U373MG, D645, D54 and T98G), were obtained from ATCC and used at passages 6-8. Cells ... 6 display the statistical and diagrammatic results, respectively, of metabolic parameters pertaining to ECAR. ... Cytochemical identification of cerebral glycogen and glucose-6-phosphatase activity under normal and experimental conditions II ... 6), has been demonstrated to inhibit tumour progression in vivo in lung and breast cancer (5, 7). ...
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Vascular endothelial growth factor receptor 2 | DrugBank Online
N-(4-phenoxyphenyl)-2-[(pyridin-4-ylmethyl)amino]nicotinamide. experimental. unknown. Details. DB07274. N-cyclopropyl-6-[(6,7- ... 1991 Sep;6(9):1677-83. [Article] *Patterson C, Perrella MA, Hsieh CM, Yoshizumi M, Lee ME, Haber E: Cloning and functional ... 6-chloro-N-pyrimidin-5-yl-3-{[3-(trifluoromethyl)phenyl]amino}-1,2-benzisoxazole-7-carboxamide. experimental. unknown. Details ... 3-(2-aminoquinazolin-6-yl)-1-(3,3-dimethylindolin-6-yl)-4-methylpyridin-2(1H)-one. experimental. unknown. Details. ...
MedKoo Biosciences
IUPAC/Chemical Name: N-(4-(1-cyanocyclopentyl)phenyl)-2-((pyridin-4-ylmethyl)amino)nicotinamide methanesulfonate ... 6: Wang X, Wu X, Yang Y, Xu W, Tian H, Lian B, Chi Z, Si L, Sheng X, Kong Y, Zhou L, Mao L, Li S, Tang B, Yan X, Bai X, Guo J, ... 2022 Dec;13(6):3300-3313. doi: 10.21037/jgo-22-1158. PMID: 36636043; PMCID: PMC9830353.. 17: Zhao M, Ma H, Cheng P, Yang H, ... InChi Code: InChI=1S/C24H23N5O.CH4O3S/c25-17-24(11-1-2-12-24)19-5-7-20(8-6-19)29-23(30)21-4-3-13-27-22(21)28-16-18-9-14-26-15- ...
The Journal of Toxicological Sciences
6) Combined ingestion of two kinds of metal-containing drugs with clioquinol appeared to yield more favorable effects than ... The tolerance for glucose in the body was clearly depressed in rats in the 6-AN group, while no significant difference in the ... It is, accordingly, speculated that the glucosuria induced by 6-AN was not only due to the hyperglycemia, but also due to the ... Sodium and glucose were excreted maximally into the urine at 2 to 4 and at 4 to 6 hours, respectively, after the administration ...
Figures and data in Gradients of glucose metabolism regulate morphogen signalling required for specifying tonotopic...
Data are mean ± standard error of the mean (SEM); E6: n = 6, E9: n = 4, E14: n = 6, and E16: n = 5 biological replicates. *p , ... 6-AN induced a slight expansion of the Bmp7 gradient into the proximal region (indicated by black arrows) and a reduction in ... Data are mean ± standard error of the mean (SEM). E9: n = 9, E10: n = 6, E14: n = 13 independent biological replicates. *p = , ... 2-DOG) Controls: n = 6, 2-DOG: n = 6. Data mean ± standard error of the mean (SEM). **p , 0.01 two-way analysis of variance ( ...
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6-Oxoprostaglandin F1 alpha use 6-Ketoprostaglandin F1 alpha 6-Phosphofructo-2-kinase-fructose-2,6-bisphosphatase use ... 2,6-Dichlorophenolindophenol use 2,6-Dichloroindophenol 3 beta-Hydroxy-delta-5-Steroid Dehydrogenase use Progesterone Reductase ... 6-Phosphofructokinase, Liver Type use Phosphofructokinase-1, Liver Type 6-Phosphofructokinase, Muscle Type use ... 2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy- ...