1-Pyrroline-5-carboxylate dehydrogenase
III Delta1-Pyrroline-5-carboxylic acid dehydrogenase". J. Biol. Chem. 235: 3218-3223. Portal: Biology (Articles with short ... L-pyrroline-5-carboxylate-NAD+ oxidoreductase, and 1-pyrroline-5-carboxylate:NAD+ oxidoreductase. This enzyme participates in ... In enzymology, a 1-pyrroline-5-carboxylate dehydrogenase (EC 1.2.1.88) is an enzyme that catalyzes the chemical reaction (S)-1- ... pyrroline-5-carboxylate + NAD+ + 2 H2O ⇌ {\displaystyle \rightleftharpoons } L-glutamate + NADH + H+ The three substrates of ...
Aldehyde dehydrogenase 4 family, member A1
1998). "Mutations in the Delta1-pyrroline 5-carboxylate dehydrogenase gene cause type II hyperprolinemia". Hum. Mol. Genet. 7 ( ... This protein belongs to the aldehyde dehydrogenase family of proteins. This enzyme is a mitochondrial matrix NAD-dependent ... dehydrogenase that catalyzes the second step of the proline degradation pathway, converting pyrroline-5-carboxylate to ... "Entrez Gene: ALDH4A1 aldehyde dehydrogenase 4 family, member A1". Human ALDH4A1 genome location and ALDH4A1 gene details page ...
Hyperprolinemia
This enzyme helps to break down the pyrroline-5-carboxylate produced in the previous reaction, converting it to the amino acid ... A deficiency of either proline oxidase or pyrroline-5-carboxylate dehydrogenase results in a buildup of proline in the body. A ... This enzyme begins the process of degrading proline by starting the reaction that converts it to pyrroline-5-carboxylate.[ ... Pyridoxal phosphate de-activation by pyrroline-5-carboxylic acid. Increased risk of vitamin B6 deficiency and seizures in ...
Proline dehydrogenase
In enzymology, proline dehydrogenase (PRODH) (EC 1.5.5.2, formerly EC 1.5.99.8) is an enzyme of the oxidoreductase family, ... It employs one cofactor, FAD, which requires riboflavin (vitamin B2). Proline dehydrogenase is in humans encoded by PRODH and ... Servet C, Ghelis T, Richard L, Zilberstein A, Savoure A (January 2012). "Proline dehydrogenase: a key enzyme in controlling ... Funck D, Eckard S, Müller G (April 2010). "Non-redundant functions of two proline dehydrogenase isoforms in Arabidopsis". BMC ...
1-Pyrroline-5-carboxylic acid
In many prokaryotes, proline dehydrogenase and P5C dehydrogenase form a bifunctional enzyme that prevents the release of P5C ... The enzyme pyrroline-5-carboxylate reductase converts P5C into proline In proline degradation, the enzyme proline dehydrogenase ... "Entrez Gene: ALDH18A1 aldehyde dehydrogenase 18 family, member A1". Liu, Li-Kai; Becker, Donald F.; Tanner, John J. (2017-10-15 ... Heacock, Anne M.; Williams, Irene H.; Frank, Leonard H.; Adams, Elijah (1975-04-01). "Δ1-Pyrroline-5-carboxylate and Δ1- ...
List of diseases (D)
Dengue fever Dennis-Cohen syndrome Dennis-Fairhurst-Moore syndrome Dent disease Dental aberrations steroid dehydrogenase ... hypertension Dextrocardia with situs inversus Dextrocardia Dextrocardia-bronchiectasis-sinusitis D-glycerate dehydrogenase ... duplication Digitorenocerebral syndrome Digoxin toxicity Dihydropteridine reductase deficiency Dihydropyrimidine dehydrogenase ... nephrogenic type 1 Diabetes insipidus, nephrogenic type 2 Diabetes insipidus, nephrogenic type 3 Diabetes insipidus, ...
Cutis laxa
Aldehyde Dehydrogenase 18 Family, Member A1; ALDH18A1 - 138250 Reddy GP, Mishra B, Upadhyaya DN (2019). "Acquired Localized ... Pyrroline-5-Carboxylate Reductase 1; PYCR1 - 179035 Online Mendelian Inheritance in Man (OMIM): ... 8 (1): 42-51. doi:10.1159/000443696. PMC 4899661. PMID 27293393. Bouloc A, Godeau G, Zeller J, Wechsler J, Revuz J, Cosnes A ( ... 64 (1): 55-58. doi:10.4103/ijd.IJD_14_18. PMC 6340237. PMID 30745636. Rongioletti F, Cutolo M, Bondavalli P, Rebora A (January ...
Proline
Muzammil S, Shrestha A, Dadshani S, Pillen K, Siddique S, Léon J, Naz AA (October 2018). "An Ancestral Allele of Pyrroline-5- ... carboxylate synthase1 Promotes Proline Accumulation and Drought Adaptation in Cultivated Barley". Plant Physiology. 178 (2): ... which is reduced to proline by pyrroline-5-carboxylate reductase (using NADH or NADPH), or turned into ornithine by ornithine ... 34 (5): 681-701.e10. doi:10.1016/j.cmet.2022.04.001. hdl:10230/53513. PMID 35508109. S2CID 248528026. Pavlov MY, Watts RE, Tan ...
Pyrrole
For example, Birch reduction of pyrrole esters and amides produced pyrrolines, with the regioselectivity depending on the ... Structural analogs of pyrrole include: Pyrroline, a partially saturated analog with one double bond Pyrrolidine, the saturated ... which is reduced to proline by pyrroline-5-carboxylate reductase (using NADH or NADPH), or turned into ornithine by ornithine ... Pyrroles can undergo reductions to pyrrolidines and to pyrrolines. ...
Arginine and proline metabolism
... which is reduced to proline by pyrroline-5-carboxylate reductase (using NADH or NADPH), or turned into ornithine by ornithine ... Glutamate-5-semialdehyde is first formed by glutamate 5-kinase (ATP-dependent) and glutamate-5-semialdehyde dehydrogenase ( ... which requires NADH or NADPH). This can then either spontaneously cyclize to form 1-pyrroline-5-carboxylic acid, ... ISBN 1-57259-153-6.. (Proteinogenic amino acids, Basic amino acids). ...
PYCR1
Pyrroline-5-carboxylate reductase 1, mitochondrial is an enzyme that in humans is encoded by the PYCR1 gene. This gene encodes ... "Entrez Gene: PYCR1 pyrroline-5-carboxylate reductase 1". Reversade B, Escande-Beillard N, Dimopoulou A, Fischer B, Chng SC, Li ... Meng Z, Lou Z, Liu Z, Li M, Zhao X, Bartlam M, Rao Z (June 2006). "Crystal structure of human pyrroline-5-carboxylate reductase ... Yeh GC, Roth EF, Phang JM, Harris SC, Nagel RL, Rinaldi A (May 1984). "The effect of pyrroline-5-carboxylic acid on nucleotide ...
Aldehyde dehydrogenase 18 family, member A1
Hu CA, Khalil S, Zhaorigetu S, Liu Z, Tyler M, Wan G, Valle D (November 2008). "Human Delta1-pyrroline-5-carboxylate synthase: ... The encoded protein catalyzes the reduction of glutamate to delta1-pyrroline-5-carboxylate, a critical step in the de novo ... This gene is a member of the aldehyde dehydrogenase family and encodes a bifunctional ATP- and NADPH-dependent mitochondrial ... "Entrez Gene: ALDH18A1 aldehyde dehydrogenase 18 family, member A1". Fischer-Zirnsak B, Escande-Beillard N, Ganesh J, Tan YX, Al ...
List of MeSH codes (D08)
... pyrroline carboxylate reductases MeSH D08.811.682.662.750 - saccharopine dehydrogenases MeSH D08.811.682.662.825 - ... malate dehydrogenase MeSH D08.811.682.047.748 - malate dehydrogenase (nadp+) MeSH D08.811.682.047.892 - xanthine dehydrogenase ... acetoin dehydrogenase MeSH D08.811.682.047.070 - alcohol dehydrogenase MeSH D08.811.682.047.150 - carbohydrate dehydrogenases ... acyl-coa dehydrogenase MeSH D08.811.682.660.150.150 - acyl-coa dehydrogenase, long-chain MeSH D08.811.682.660.150.200 - acyl- ...
Nicotinamide adenine dinucleotide
"Crystal structures of Delta1-piperideine-2-carboxylate/Delta1-pyrroline-2-carboxylate reductase belonging to a new family of ... including glyceraldehyde 3-phosphate dehydrogenase and pyruvate dehydrogenase. In healthy mammalian tissues, estimates of the ... Lesk AM (1995). "NAD-binding domains of dehydrogenases". Curr. Opin. Struct. Biol. 5 (6): 775-83. doi:10.1016/0959-440X(95) ... ISBN 978-0-911910-27-8. Biellmann JF, Lapinte C, Haid E, Weimann G (1979). "Structure of lactate dehydrogenase inhibitor ...
Biosynthesis
Pyrroline-5-carboxylate is further reduced by the enzyme pyrroline-5-carboxylate reductase (P5CR) to yield a proline amino acid ... Aspartate-semialdehyde dehydrogenase catalyzes the reduction reaction by dephosphorylation of aspartyl-β-phosphate to yield ... kinase catalyzes the initial step in the diaminopimelic acid pathway by transferring a phosphoryl from ATP onto the carboxylate ... The next reaction is catalyzed by the enzyme pyrroline-5-carboxylate synthase (P5CS), which catalyzes the reduction of the ϒ- ...
NOXRED1
"ALDH18A1 aldehyde dehydrogenase 18 family member A1 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022 ... "PYCR1 pyrroline-5-carboxylate reductase 1 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-10-22. " ... "PYCR2 pyrroline-5-carboxylate reductase 2 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-10-22. " ... "PYCR3 pyrroline-5-carboxylate reductase 3 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-10-22. " ...
Bruno Reversade
2015-09-03). "Recurrent De Novo Mutations Affecting Residue Arg138 of Pyrroline-5-Carboxylate Synthase Cause a Progeroid Form ... January 30, 2020). "Loss-of-function mutations in UDP-Glucose 6-Dehydrogenase cause recessive developmental epileptic ... ISBN 978-1-107-00382-8 - via Google Books. Rosier, Florence (8 July 2014). "Sur la piste d'un gène responsable de la gémellité ... 167 (1): 187-202.E17. doi:10.1016/j.cell.2016.09.001. PMID 27662089. Zhonga, Franklin L.; Robinson, Kim; Teo, Daniel Eng Thiam ...
List of EC numbers (EC 1)
... benzaldehyde dehydrogenase (NAD+) EC 1.2.1.29: aryl-aldehyde dehydrogenase EC 1.2.1.30: carboxylate reductase (NADP+) EC 1.2. ... pyrroline-5-carboxylate reductase EC 1.5.1.3: dihydrofolate reductase EC 1.5.1.4: Now included with EC 1.5.1.3 dihydrofolate ... EC 1.1.1.1: alcohol dehydrogenase EC 1.1.1.2: alcohol dehydrogenase (NADP+) EC 1.1.1.3: homoserine dehydrogenase EC 1.1.1.4: (R ... formylmethanofuran dehydrogenase EC 1.2.99.6: carboxylate reductase EC 1.2.99.7: aldehyde dehydrogenase (FAD-independent) EC ...
List of EC numbers (EC 3)
... pyruvate dehydrogenase (acetyl-transferring)]-phosphatase EC 3.1.3.44: [acetyl-CoA carboxylase]-phosphatase EC 3.1.3.45: 3- ... 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)]-phosphatase EC 3.1.3.53: [myosin-light-chain] ... EC 3.2.1.91: cellulose 1,4-β-cellobiosidase (non-reducing end) EC 3.2.1.92: peptidoglycan β-N-acetylmuramidase EC 3.2.1.93: α,α ... EC 3.4.21.60 EC 3.4.21.60, scutelarin EC 3.4.99.29: Deleted entry: Myxobacter AL-1 proteinase I EC 3.4.99.30: Transferred entry ...