"Structural basis for protein-protein interactions in the 14-3-3 protein family". Proc. Natl. Acad. Sci. U.S.A. 103 (46): 17237- ... These proteins contain a number of known common modification domains, including regions for divalent cation interaction, ... To date, the crystal structures of six classes of these proteins have been resolved and deposited in the public domain.[ ... More than 200 signaling proteins have been reported as 14-3-3 ligands. Elevated amounts of 14-3-3 proteins in cerebrospinal ...
2000). "Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins". ... "The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins". Cell. 83 ... The cIAP2 protein contains three BIR domains, a UBA domain, a CARD domain and a RING finger domain. Transcript variants ... The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to ...
Look up tau protein or tau in Wiktionary, the free dictionary. tau+Proteins at the U.S. National Library of Medicine Medical ... The tau proteins were identified in 1975 as heat-stable proteins essential for microtubule assembly, and since then they have ... Tau protein has been shown to interact with: Alpha-synuclein, FYN, Proto-oncogene tyrosine-protein kinase Src S100B, and YWHAZ ... The tau proteins (abbreviated from tubulin associated unit) are a group of six highly soluble protein isoforms produced by ...
Serine/threonine-protein kinase D1 is an enzyme that in humans is encoded by the PRKD1 gene. Members of the protein kinase D ( ... Holmes AM (1996). "In vitro phosphorylation of human immunodeficiency virus type 1 Tat protein by protein kinase C: evidence ... "Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and - ... "The pleckstrin homology domain of protein kinase D interacts preferentially with the eta isoform of protein kinase C". J. Biol ...
... , is a protein that in humans is encoded by the MSX1 gene. MSX1 transcripts are not only found in ... MSX1 and LHX2 form a protein complex in the absence of DNA, and that DNA binding by either protein alone can occur at the ... Phenotypes caused by deficiency of MSX1 protein might depend on the localization of mutations and their effect on the protein ... MSX1 has been shown to interact with DLX5, CREB binding protein, Sp1 transcription factor, DLX2, TATA binding protein and Msh ...
The yeast homolog Sec17, pictured above contains fourteen α-helices and has the approximate dimensions of 85 Å × 35 Å × 35 Å ... SNAPs associate with the proteins of the SNARE (SNAP REceptor) complex, a class of type II integral membrane protein, as well ... Some of the first proteins identified as the receptors of SNAPs were syntaxin 1, SNAP-25 (synaptosome associated protein, 25kDa ... SNAPs interact with proteins of the SNARE complex and NSF to play a key role in recycling the components of the fusion complex ...
"Prediction of EF-hand calcium-binding proteins and analysis of bacterial EF-hand proteins". Proteins. 65 (3): 643-655. doi: ... Notably, the protein contains three EF hand motifs that function as binding sites for Ca2+ ions. The protein is a member of the ... In the animal, the protein occurs together with the green fluorescent protein to produce green light by resonant energy ... Because the protein is large, it has a low leakage rate from cells compared to lipophilic dyes such as DiI. It lacks phenomena ...
Protein Science. 14 (3): 812-822. doi:10.1110/ps.04951405. ISSN 0961-8368. PMC 2279270. PMID 15722453. Hulver MW, Berggren JR, ... "Stearoyl-CoA desaturase 1 deficiency elevates insulin-signaling components and down-regulates protein-tyrosine phosphatase 1B ... "Stearoyl-CoA desaturase 1 deficiency elevates insulin-signaling components and down-regulates protein-tyrosine phosphatase 1B ... 3 (4): 271-80. doi:10.2174/1568008033340117. PMID 14683458. Shiwaku K, Hashimoto M, Kitajima K, Nogi A, Anuurad E, Enkhmaa B, ...
Koyata H, Hiraga K (February 1991). "The glycine cleavage system: structure of a cDNA encoding human H-protein, and partial ... Activity is augmented by high-protein diets and starvation. During periods of low carbohydrates, serine is converted into ... Protein Science. 14 (3): 791-8. doi:10.1110/ps.041179105. PMC 2279282. PMID 15689518. "KEGG ENZYME Database Entry". Kyoto ... Figure 3 and Figure 4). The reaction catalyzed by serine dehydratase follows the pattern seen by other PLP-dependent reactions ...
Users can search the database for a particular motion by either protein name or Protein Data Bank ID number. Typically, however ... ISBN 978-0-470-18105-8. Frauenfelder, Hans (10 June 2010). "Chapter 26 on Protein Motions". The Physics of Proteins: An ... users will enter the database via the Protein Data Bank, which often provides a hyperlink to the molmovdb entry for proteins ... Database of protein conformational diversity Gu, Jenny; Bourne, Philip E. (March 2009). Structural Bioinformatics (2nd ed.). ...
... is a protein that in humans is encoded by the SLC25A3 gene. The encoded protein is a ... The encoded protein (PHC) is a multi-pass transmembrane protein located in the mitochondrial inner membrane; it contains six ... "SLC25A3 - Phosphate carrier protein, mitochondrial precursor - Homo sapiens (Human) - SLC25A46 gene & protein". www.uniprot.org ... "SLC25A3 - Phosphate carrier protein, mitochondrial". Cardiac Organellar Protein Atlas Knowledgebase (COPaKB). Dolce V, ...
October 2022). "Discovery and Biological Characterization of PRMT5:MEP50 Protein-Protein Interaction Inhibitors". Journal of ... in the binding groove between PRMT5 and peptides derived from the adaptor proteins lead to development of protein-protein ... "A novel WD repeat protein component of the methylosome binds Sm proteins". J. Biol. Chem. 277 (10): 8243-7. doi:10.1074/jbc. ... "Symmetrical dimethylation of arginine residues in spliceosomal Sm protein B/B' and the Sm-like protein LSm4, and their ...
The protein belongs to the S5P family of ribosomal proteins. It is located in the cytoplasm. This gene shares sequence ... Swiercz R, Person MD, Bedford MT (2005). "Ribosomal protein S2 is a substrate for mammalian PRMT3 (protein arginine ... a protein with a dual subcellular fate, is interacting with human ribosomal protein S2". Biochem. Biophys. Res. Commun. 338 (2 ... Overview of all the structural information available in the PDB for UniProt: P15880 (40S ribosomal protein S2) at the PDBe-KB. ...
Methylosome protein 50 is a protein that in humans is encoded by the WDR77 gene. WD repeat-containing protein 77 has been shown ... "A novel WD repeat protein component of the methylosome binds Sm proteins". J Biol Chem. 277 (10): 8243-7. doi:10.1074/jbc. ... 2005). "Identification of proteins interacting with the RNAPII FCP1 phosphatase: FCP1 forms a complex with arginine ... Overview of all the structural information available in the PDB for UniProt: Q9BQA1 (Methylosome protein 50) at the PDBe-KB. v ...
The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has ... Draetta G, Eckstein J (1997). "Cdc25 protein phosphatases in cell proliferation". Biochim. Biophys. Acta. 1332 (2): M53-63. doi ... "Protein kinase CK2 regulates CDC25B phosphatase activity". Oncogene. 22 (2): 220-32. doi:10.1038/sj.onc.1206107. ISSN 0950-9232 ... 14 (20): 2485-95. doi:10.1038/sj.onc.1201063. PMID 9188863. Booher RN, Holman PS, Fattaey A (1997). "Human Myt1 is a cell cycle ...
Forkhead box O6 is a protein that in humans is encoded by the FOXO6 gene. FoxO6 is expressed in the liver, skeletal muscle, and ... 5 (3): 233-40. doi:10.1111/1753-0407.12027. PMC 3657578. PMID 23324123. Qinyu L, Long C, Zhen-dong D, Min-min S, Wei-ze W, Wei- ... 587 (14): 2105-11. doi:10.1016/j.febslet.2013.05.027. PMID 23714368. S2CID 38064268. v t e (Articles with short description, ... Tzivion G, Dobson M, Ramakrishnan G (November 2011). "FoxO transcription factors; Regulation by AKT and 14-3-3 proteins". ...
This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ... "The kinesin-like motor protein KIF1C occurs in intact cells as a dimer and associates with proteins of the 14-3-3 family". J. ... Han L, Wong D, Dhaka A, Afar D, White M, Xie W, Herschman H, Witte O, Colicelli J (1997). "Protein binding and signaling ... Aoki H, Hayashi J, Moriyama M, Arakawa Y, Hino O (2000). "Hepatitis C Virus Core Protein Interacts with 14-3-3 Protein and ...
M-phase inducer phosphatase 1 also known as dual specificity phosphatase Cdc25A is a protein that in humans is encoded by the ... In contrast, some invertebrates harbour two (e.g., the Drosophila proteins String and Twine) or four (e.g., C. elegans Cdc-25.1 ... Dual-specificity protein phosphatases remove phosphate groups from phosphorylated tyrosine and serine / threonine residues. ... Coqueret O, Bérubé G, Nepveu A (1998). "The mammalian Cut homeodomain protein functions as a cell-cycle-dependent ...
Raf kinases A-Raf kinase B-Raf kinase KSR1 protein KSR2 protein GRCm38: Ensembl release 89: ENSMUSG00000000441 - Ensembl, May ... Yuryev A, Wennogle LP (February 2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid ... a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway". ... and the enzymes dedicated for removal of these phosphates are the protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A ...
... protein unfolding) or other diagenetic processes. Ancient proteins also tend to be fragmented, damaged and altered. Proteins ... Ancient enamel proteins are useful when aDNA or other proteins do not survive, and they have been analysed to understand ... However, ancient proteins are still one of the most informative biomolecules. Proteins tend to degrade more slowly than DNA, ... There is also the issue of dark proteomes (unknown protein regions that cannot be sequenced); approximately 44-54% of proteins ...
... (SP-A2), also known as Pulmonary surfactant-associated protein A2 (PSP-A2) is a protein that in humans is ... Together with (surfactant protein A1 ) SP-A1, they are the most abundant proteins of pulmonary surfactant. SP-A2 binds to the ... SP-A2 is a protein of 248 amino acids usually found in large oligomeric structures. The mature SP-A2 monomer is a 35kDa protein ... Using specific monoclonal antibodies for Surfactant protein A, the protein can be detected in lung alveolar type II pneumocytes ...
... +protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) v t e (Articles with short ... or K2P18.1 is a protein that in humans is encoded by the KCNK18 gene. K2P18.1 is a potassium channel containing two pore- ... Czirják G, Vuity D, Enyedi P (2008). "Phosphorylation-dependent binding of 14-3-3 proteins controls TRESK regulation". J. Biol ...
The protein can be a toxin, an apoptotic factor, or a viral protein. Toxins such as diphtheria toxin interfere with cellular ... "Regulation of telomerase activity and anti-apoptotic function by protein-protein interaction and phosphorylation". FEBS Letters ... Viral proteins like viral thymidine kinase can be used for specific targeting of a drug. By introducing a prodrug only ... the introduction of hTERT has an advantage over the use of viral protein for immortalization in that it does not involve the ...
... camp-responsive element-binding protein (CREB) and CREB-binding protein (CBP). It has been proposed that recruitment of ... Mutant atrophin-1 proteins have been found in neuronal intranuclear inclusions (NII) and diffusely accumulated in the neuronal ... Atrophin-1 may be a dispensable or redundant protein as mice bred with a null allele for atrophin-1 produce viable and fertile ... It contains a putative nuclear localization signal in the N-terminus of the protein and a putative nuclear export signal in the ...
This protein family is known for regulating signal transduction pathways primarily through binding phosphoserine proteins, ... is a protein that in humans is encoded by the YWHAZ gene on chromosome 8. The protein encoded by this gene is a member of the ... though it can also bind phosphothreonine proteins and unphosphorylated proteins. By extension, 14-3-3 proteins are involved in ... "New insights into potential functions for the protein 4.1 superfamily of proteins in kidney epithelium". Frontiers in ...
However, the Hd3a protein is found in neither of these places but instead accumulates in the SAM which shows that Hd3a protein ... CO protein promotes transcription of another gene called Flowering Locus T (FT). By this mechanism, CO protein may only reach ... and is then translated into CO protein. However CO protein is stable only in light, so levels stay low throughout short days ... The FT protein resulting from the short period of CO transcription factor activity is then transported via the phloem to the ...
T-cell leukemia homeobox protein 2 is a protein that in humans is encoded by the TLX2 gene. TLX2 has been shown to interact ... Tang SJ, Suen TC, McInnes RR, Buchwald M (September 1998). "Association of the TLX-2 homeodomain and 14-3-3eta signaling ... proteins". The Journal of Biological Chemistry. 273 (39): 25356-63. doi:10.1074/jbc.273.39.25356. PMID 9738002. v t e (Articles ... "Association of the TLX-2 homeodomain and 14-3-3eta signaling proteins". The Journal of Biological Chemistry. 273 (39): 25356-63 ...
The cause was determined to be a histidine-to-tyrosine (amino acid) substitution at position 274 in its neuraminidase protein.[ ... Sialic acid is a negatively charged sugar associated with the protein and lipid portions of lipoproteins.[citation needed] To ... A single hemagglutinin-neuraminidase protein can combine neuraminidase and hemagglutinin functions, such as in mumps virus and ... Neuraminidase also cleaves sialic acid residues from viral proteins, preventing aggregation of viruses.[medical citation needed ...
ISBN 1-59745-189-4. Anson ML, Protein Denaturation and the Properties of Protein Groups, Advances in Protein Chemistry, 2, 361- ... Protein Sci. 4(10), 2138-2148 (1995) Robertson, A.D., Murphy, K.P. Protein structure and the energetics of protein stability, ( ... 1992) "Physical Basis for the Stability of the Folded Conformations of Proteins", in Protein Folding, TE Creighton, ed., W. H. ... "The use of high-pressure nuclear magnetic resonance to study protein folding". In Bai, Yawen; Nussinov, Ruth (eds.). Protein ...
... is a mammalian gene encoding the protein CBL which is an E3 ubiquitin-protein ligase involved in cell signalling and protein ... "The Cbl proteins are binding partners for the Cool/Pix family of p21-activated kinase-binding proteins". FEBS Lett. 550 (1-3): ... "The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src ... "The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the ...