Pasqualini JR, Chetrite G (2008). "The anti-aromatase effect of progesterone and of its natural metabolites 20alpha- and 5alpha ... dihydroprogesterone in the MCF-7aro breast cancer cell line". Anticancer Res. 28 (4B): 2129-33. PMID 18751385. Sitruk-Ware R, ... 20α-DHP can be transformed back into progesterone by 20α-HSDs and by the 17β-HSD HSD17B2. HSD17B2 is expressed in the human ... In animal studies, 20α-DHP has been found to be selectively taken up into and retained in target tissues such as the uterus, ...

I. C21 steroids: progesterone, 16 alpha-hydroxyprogesterone, 17 alpha-hydroxyprogesterone, 20 alpha-dihydroprogesterone, delta ... 20 (6). Retrieved 27 June 2014. "Assisted Reproductive Technology (ART)". Centers for Disease Control. Retrieved 27 June 2014 ... Archived from the original (PDF) on 2009-02-20. "Dead URL". Sexuality, Reproduction and Menopause magazine. Archived from the ... Archived from the original on 2016-07-20. Retrieved 2016-07-27. Hypoactive Sexual Desire Disorder Time Magazine article ...

5-alpha-dihydroprogesterone MeSH D06.472.334.851.687.750.478 - hydroxyprogesterones MeSH D06.472.334.851.687.750.478.400 - 17- ... alpha subunit MeSH D06.472.351.576.463 - luteinizing hormone MeSH D06.472.351.576.463.249 - glycoprotein hormones, alpha ... alpha-msh MeSH D06.472.699.631.525.690.583.075 - beta-msh MeSH D06.472.699.631.525.690.583.115 - gamma-msh MeSH D06.472.699.631 ... alpha-msh MeSH D06.472.734.525.690.583.075 - beta-msh MeSH D06.472.734.525.690.583.115 - gamma-msh MeSH D06.472.734.525.883 - ...

5-alpha-dihydroprogesterone MeSH D04.808.745.558.050 - alfaxalone alfadolone mixture MeSH D04.808.745.558.783 - ... MeSH D04.345.051.500 - crown ethers MeSH D04.345.103.222 - alpha-cyclodextrins MeSH D04.345.103.333 - beta-cyclodextrins MeSH ... 17-alpha-hydroxyprogesterone MeSH D04.808.745.745.654.829.614 - medroxyprogesterone MeSH D04.808.745.745.654.829.614.500 - ... medroxyprogesterone 17-acetate MeSH D04.808.745.745.725 - pregnenolone MeSH D04.808.745.745.725.395 - 17-alpha- ...

3 alpha HP)". Brain Research. 645 (1-2): 325-329. doi:10.1016/0006-8993(94)91667-5. ISSN 0006-8993. PMID 7914815. S2CID ... 5α-Dihydroprogesterone 5β-Dihydroprogesterone 3β-Androstanediol Pregnenolone Progesterone 3-acetyl enol ether Quingestrone ... Unlike 3α-dihydroprogesterone (3α-DHP), 3β-DHP does not act as a positive allosteric modulator of the GABAA receptor, which is ... 3β-Dihydroprogesterone (3β-DHP), also known as 3β-hydroxyprogesterone, or pregn-4-en-3β-ol-20-one (4-pregnenolone, δ4- ...

3 alpha HP)". Brain Research. 645 (1-2): 325-329. doi:10.1016/0006-8993(94)91667-5. ISSN 0006-8993. PMID 7914815. S2CID ... 3β-Dihydroprogesterone 5α-Dihydroprogesterone 5β-Dihydroprogesterone Pregnanolone Pregnenolone Neurosteroids and Brain Function ... 3α-Dihydroprogesterone (3α-DHP), also known as 3α-hydroxyprogesterone, as well as pregn-4-en-3α-ol-20-one, is an endogenous ... "Reduction of predator odor-induced anxiety in mice by the neurosteroid 3 alpha-hydroxy-4-pregnen-20-one ( ...

It can be converted by 20β-HSD into progesterone in the uterus. The effects of 20β-HSD on the uterus, mammary glands, and in ... 20β-Dihydroprogesterone (20β-DHP), also known as 20β-hydroxyprogesterone (20β-OHP), is an endogenous metabolite of progesterone ... Lisboa, B. P.; Holtermann, M. (1976). "METABOLISM OF 20β-HYDROXY-4-PREGNEN-3-ONE IN UTERINE TISSUE OF NON-PREGNANT RATS IN ... Kumaresan, P.; Turner, C. W. (1968). "A Comparison of 20 -hydroxy-pregn-4-ene-3-one and Progesterone on Mammary Gland Growth of ...

Breuer H, Kime DE, Knuppen R (September 1973). "Metabolism of 6-chloro-9 beta, 10 alpha-pregna-1,4,6-triene-3,20-dione in rat, ... 20α-Dihydrotrengestone (20α-DHTG), also known as 20α-hydroxytrengestone, as well as 6-chloro-20(S)-hydroxy-9β,10α-pregna-1,4,6- ... It appears that trengestone is a prodrug of 20α-DHTG, as it is largely transformed into this metabolite when given orally in ... 20α-Dihydrodydrogesterone 20α-Dihydroprogesterone Dixon R, Tormey P, Darragh A (March 1975). "Disposition of the retro-steroid ...

Melcangi RC, Celotti F, Martini L (March 1994). "Progesterone 5-alpha-reduction in neuronal and in different types of glial ... "Brain 5alpha-dihydroprogesterone and allopregnanolone synthesis in a mouse model of protracted social isolation". Proceedings ... alpha-hydroxysteroid dehydrogenase for neurosteroids and its inhibition by benzodiazepines" (pdf). Biological & Pharmaceutical ... Usami N, Yamamoto T, Shintani S, Ishikura S, Higaki Y, Katagiri Y, Hara A (April 2002). "Substrate specificity of human 3(20) ...

11α-Hydroxyprogesterone 5α-Dihydroprogesterone 20-Dihydroprogesterone 11-Deoxycorticosterone 11-Deoxycortisol 17α- ... 17-alpha hydroxyprogesterone caproate, and related progestins". Am. J. Obstet. Gynecol. 197 (6): 599.e1-7. doi:10.1016/j.ajog. ... Normal levels are 3-90 ng/dl in children, and in women, 20-100 ng/dl prior to ovulation, and 100-500 ng/dl during the luteal ... 20-dione, is a naturally occurring pregnane steroid. It features ketone groups at the C3 and C20 positions, a hydroxyl group at ...

Ellsworth, K.; Harris, G. (1995). "Expression of the type 1 and 2 steroid 5 alpha-reductases in human fetal tissues". Biochem ... also known as 17α-hydroxy-dihydroprogesterone (17‐OH-DHP) is an endogenous steroid, a metabolite of 17α-hydroxyprogesterone. 5α ... Hastings C, Hansson V (August 1981). "Kinetic properties of the soluble 3 alpha-hydroxysteroid dehydrogenase from rat testis ... delta 4-3-ketosteroid 5 alpha-oxidoreductase of rat prostate". J Biol Chem. 246 (8): 2584-93. doi:10.1016/S0021-9258(18)62328-2 ...

"PAQR7 - Membrane progestin receptor alpha - Homo sapiens (Human) - PAQR7 gene & protein". www.uniprot.org. Retrieved 2015-10-30 ... The progesterone active metabolites 5α-dihydroprogesterone, also a progestogen, and allopregnanolone, which are positive ... "PAQR7 - Membrane progestin receptor alpha - Homo sapiens (Human) - PAQR7 gene & protein". www.uniprot.org. Retrieved 2015-10-27 ... Thomas P (May 2008). "Characteristics of membrane progestin receptor alpha (mPRalpha) and progesterone membrane receptor ...

5α-dihydroprogesterone (5α-DHP), 5β-dihydroprogesterone (5β-DHP) (very weak), 3β-dihydroprogesterone (3β-DHP), 11- ... 17-alpha hydroxyprogesterone caproate, and related progestins". Am. J. Obstet. Gynecol. 197 (6): 599.e1-7. doi:10.1016/j.ajog. ... The equine placenta produces a variety of progestogens, primarily 5α-dihydroprogesterone and 5α,20α-tetrahydroprogesterone, ... In the Clauberg bioassay the 3β-hydroxy-4-pregnen-20-one shows about the same potency as progesterone (34). In regard to the ...

Kaminski RM, Marini H, Ortinski PI, Vicini S, Rogawski MA (2006). "The pheromone androstenol (5 alpha-androst-16-en-3 alpha-ol ... of the above-listed inhibitory androstane neurosteroids 3α-Dihydroprogesterone (3α-DHP): pregn-4-en-3α-ol-20-one - GABAA ... NMDA receptor positive allosteric modulator 3β-Dihydroprogesterone (3β-DHP): pregn-4-en-3β-ol-20-one - GABAA receptor negative ... GABAA receptor positive allosteric modulator 5β-Dihydroprogesterone (5β-DHP; pregnanedione): 5β-pregnane-3,20-dione - GABAA ...

Ozeki T, Takahashi Y, Nakayama K, Kamataki T (September 2002). "Hepatocyte nuclear factor (HNF)-4 alpha/gamma, HNF-1 alpha, and ... Nishizawa M, Nakajima T, Yasuda K, Kanzaki H, Sasaguri Y, Watanabe K, Ito S (February 2000). "Close kinship of human 20alpha- ... resulting in a selective facilitation of 5α-dihydroprogesterone conversion into allopregnanolone. This action has been ... "Hepatocyte nuclear factor-4 alpha/gamma and hepatocyte nuclear factor-1 alpha as causal factors of interindividual difference ...

Azzouni F, Godoy A, Li Y, Mohler J (2012). "The 5 alpha-reductase isozyme family: a review of basic biology and their role in ... progesterone → 5α-dihydroprogesterone → allopregnanolone → 5α-pregnane-3α,17α-diol-20-one → androsterone → 5α-androstane-3α,17β ... 17-. ISBN 978-1-139-42645-9. Azzouni F, Godoy A, Li Y, Mohler J (2012). "The 5 alpha-reductase isozyme family: a review of ... Fertig R, Shapiro J, Bergfeld W, Tosti A (2017). "Investigation of the Plausibility of 5-Alpha-Reductase Inhibitor Syndrome". ...

17-alpha hydroxyprogesterone caproate, and related progestins". Am. J. Obstet. Gynecol. 197 (6): 599.e1-7. doi:10.1016/j.ajog. ... for instance 3β-dihydroprogesterone, have potent progestogenic activity, this may account for the clinical efficacy of ... In order to obtain the picture of a normal secretory phase, ten 20-mg. doses of progesterone daily are required (Ober and Weber ... In the Clauberg bioassay the 3β-hydroxy-4-pregnen-20-one shows about the same potency as progesterone (34). In regard to the ...

5α-Dihydroprogesterone 3α-Dihydroprogesterone → Allopregnanolone 3β-Dihydroprogesterone → Isopregnanolone Deoxycorticosterone ... 4-aza-5 alpha-androstan-1-en-3-one is an active site-directed slow time-dependent inhibitor of human steroid 5 alpha-reductase ... In 5 alpha reductase type 2 deficient males, the type 1 isoenzyme is thought to be responsible for their virilization at ... Azzouni F, Godoy A, Li Y, Mohler J (2012). "The 5 alpha-reductase isozyme family: a review of basic biology and their role in ...

"Prostate formation in a marsupial is mediated by the testicular androgen 5 alpha-androstane-3 alpha,17 beta-diol". Proceedings ... The 46,XX (female) relatives of affected patients, having the same mutations, were phenotypically normal and fertile. Although ... The first step in this pathway is 5α-reduction of P4 towards 5α-dihydroprogesterone (5α-DHP) by SRD5A1. 5α-DHP is then ... since it is also known as 17α-hydroxy-dihydroprogesterone). The reaction is catalyzed by SRD5A1. 17OHDHP is then converted to 5 ...

2012). "The 5 alpha-reductase isozyme family: a review of basic biology and their role in human diseases". Adv. Urol. 2012: ... 5α-reductase isoforms I and II reduce progesterone to 5α-dihydroprogesterone (5α-DHP) and deoxycorticosterone to ... Wang J, Zhao S, Luo L, Li E, Li X, Zhao Z (2018). "5-alpha Reductase Inhibitors and risk of male breast cancer: a systematic ... "FDA Alert: 5-alpha reductase inhibitors (5-ARIs): Label Change - Increased Risk of Prostate Cancer". Drugs.com. Retrieved 2014- ...

17-alpha hydroxyprogesterone caproate, and related progestins". Am. J. Obstet. Gynecol. 197 (6): 599.e1-7. doi:10.1016/j.ajog. ... and this was administered from the fifth day through the twenty-fourth day of the menstrual cycle. [...] We observed each of 33 ... progesterone is metabolized by 5α-reductase into 5α-dihydroprogesterone (5α-DHP), a compound reported to have some antagonistic ... and at the nineteenth to twenty-second day of the cycle an endometrial biopsy. [...] Although we thus demonstrated the ...

Geller J, Volk H, Lewin M (October 1961). "Objective remission of metastatic breast carcinoma in a male who received 17-alpha ... As examples, 5β-dihydroprogesterone has been found to play an important role in suppressing myometrial activity while ... Caritis SN, Feghali MN, Grobman WA, Rouse DJ (August 2016). "What we have learned about the role of 17-alpha- ... Manuck TA (December 2017). "17-alpha hydroxyprogesterone caproate for preterm birth prevention: Where have we been, how did we ...

Other metabolites of progesterone formed by the enzymes in this pathway include 3α-dihydroprogesterone, 3β-dihydroprogesterone ... 17-alpha hydroxyprogesterone caproate, and related progestins". American Journal of Obstetrics and Gynecology. 197 (6): 599.e1- ... Progesterone and some of its metabolites, such as 5β-dihydroprogesterone, are agonists of the pregnane X receptor (PXR), albeit ... Endogenous progesterone is metabolized approximately 50% into 5α-dihydroprogesterone in the corpus luteum, 35% into 3β- ...