3',5'-cyclic-GMP phosphodiesterase
... phosphate phosphodiesterase, cyclic GMP phosphodiesterase, cyclic 3′,5′-GMP phosphodiesterase, cyclic guanosine 3′,5′- ... Cyclic AMP and cyclic GMP phosphodiesterase". Biochim. Biophys. Acta. 334: 368-377. doi:10.1016/0005-2744(74)90180-6. Portal: ... cyclic-GMP phosphodiesterase (EC 3.1.4.35) catalyzes the reaction guanosine 3′,5′-cyclic phosphate + H2O ⇌ {\displaystyle \ ... phosphate phosphodiesterase, cGMP phosphodiesterase, cGMP-PDE, and cyclic guanosine 3′,5′-phosphate phosphodiesterase. As of ...
PDE11A
... cyclic-AMP and -GMP phosphodiesterase 11A is an enzyme that in humans is encoded by the PDE11A gene. The 3',5'-cyclic ... Yuasa K, Ohgaru T, Asahina M, Omori K (2001). "Identification of rat cyclic nucleotide phosphodiesterase 11A (PDE11A): ... Beavo JA, Conti M, Heaslip RJ (1994). "Multiple cyclic nucleotide phosphodiesterases". Mol. Pharmacol. 46 (3): 399-405. PMID ... cyclic nucleotide phosphodiesterase 11A: localization in human tissues". Int. J. Impot. Res. 17 (4): 320-5. doi:10.1038/sj.ijir ...
Phosphodiesterase 2
1975). "Biologic regulation through opposing influences of cyclic GMP and cyclic AMP: the Yin Yang hypothesis". Adv Cyclic ... June 1997). "cGMP-stimulated cyclic nucleotide phosphodiesterase regulates the basal calcium current in human atrial myocytes ... Bender AT, Beavo JA (September 2006). "Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use". Pharmacol. ... The PDE2 (phosphodiesterase 2) enzyme is one of 21 different phosphodiesterases (PDE) found in mammals. These different PDEs ...
Diguanylate cyclase
... cyclic di-GMP). Degradation of cyclic di-GMP to guanosine monophosphate (GMP) is catalyzed by a phosphodiesterase (PDE). ... Cyclic di-GMP binds to interface between the DGC and D2 domains stabilizing the open structure and preventing catalysis. Strong ... Often, GGDEF domains with DGC activity are found in the same proteins as c-di-GMP-specific phosphodiesterase (PDE) EAL (Glu-Ala ... Jenal U, Malone J (2006). "Mechanisms of cyclic-di-GMP signaling in bacteria". Annual Review of Genetics. 40: 385-407. doi: ...
Cyclic guanosine monophosphate
Numerous cyclic nucleotide phosphodiesterases (PDE) can degrade cGMP by hydrolyzing cGMP into 5'-GMP. PDE 5, -6 and -9 are cGMP ... Cyclic guanosine monophosphate (cGMP) is a cyclic nucleotide derived from guanosine triphosphate (GTP). cGMP acts as a second ... cyclic monophosphate (8-Br-cGMP) Francis SH, Corbin JD (August 1999). "Cyclic nucleotide-dependent protein kinases: ... Phosphodiesterase inhibitors prevent the degradation of cGMP, thereby enhancing and/or prolonging its effects. For example, ...
List of MeSH codes (D08)
... cyclic-GMP phosphodiesterase MeSH D08.811.277.352.640.150 - 3',5'-cyclic-nucleotide phosphodiesterase MeSH D08.811.277.352. ... cyclic gmp-dependent protein kinases MeSH D08.811.913.696.620.682.700.150.575 - protamine kinase MeSH D08.811.913.696.620.682. ... cyclic-nucleotide phosphodiesterases MeSH D08.811.277.352.640.295 - glycerophosphoinositol inositolphosphodiesterase MeSH ... cyclic nucleotide-regulated protein kinases MeSH D08.811.913.696.620.682.700.150.125 - cyclic amp-dependent protein kinases ...
PDE6D
Linari M, Hanzal-Bayer M, Becker J (Sep 1999). "The delta subunit of rod specific cyclic GMP phosphodiesterase, PDE delta, ... interacts with the delta subunit of rod cyclic GMP phosphodiesterase". Proceedings of the National Academy of Sciences of the ... interacts with the delta subunit of rod cyclic GMP phosphodiesterase". Proceedings of the National Academy of Sciences of the ... cyclic phosphodiesterase subunit delta is an enzyme that in humans is encoded by the PDE6D gene. PDE6D was originally ...
GAF domain
In mammals, GAF domains are found in five members of the cyclic nucleotide phosphodiesterase superfamily: PDE2, PDE5, and PDE6 ... a ubiquitous signaling motif and a new class of cyclic GMP receptor". The EMBO Journal. 19 (20): 5288-99. doi:10.1093/emboj/ ... The GAF domain is named after some of the proteins it is found in: cGMP-specific phosphodiesterases, adenylyl cyclases and FhlA ... "The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding". Proceedings of the ...
Pulmonary hypertension
Nitric oxide and cyclic GMP in cell signaling and drug development". The New England Journal of Medicine. 355 (19): 2003-11. ... Phosphodiesterase type 5 (PDE5), which is abundant in the pulmonary tissue, hydrolyzes the cyclic bond of cGMP. Consequently, ... s The U.S. FDA approved sildenafil, a selective inhibitor of cGMP specific phosphodiesterase type 5 (PDE5), for the treatment ... Levels of cAMP (which mediates most of the biological effects of prostacyclin) are reduced by phosphodiesterases 3 and 4. The ...
PDE6B
Organization of the gene for the beta-subunit of human photoreceptor cyclic GMP phosphodiesterase]". Bioorganicheskaia Khimiia ... "In vivo differential prenylation of retinal cyclic GMP phosphodiesterase catalytic subunits". The Journal of Biological ... "Enzymic basis for cyclic GMP accumulation in degenerative photoreceptor cells of mouse retina". Journal of Cyclic Nucleotide ... cyclic phosphodiesterase subunit beta is the beta subunit of the protein complex PDE6 that is encoded by the PDE6B gene. PDE6 ...
Cyclic nucleotide
The two most well-studied cyclic nucleotides are cyclic AMP (cAMP) and cyclic GMP (cGMP), while cyclic CMP (cCMP) and cyclic ... cAMP's role in this process terminates upon hydrolysis to AMP by phosphodiesterase. Cyclic nucleotides are well-suited to act ... Lincoln, TM; Cornwell TL (1991). "Towards an understanding of the mechanism of action of cyclic AMP and cyclic GMP in smooth ... As can be seen in the cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) images, the 'cyclic' ...
CGAS-STING cytosolic DNA sensing pathway
Cyclic GMP-AMP (cGAMP) is a cyclic dinucleotide (CDN) and the first to be found in metazoans. Other CDNs (c-di-GMP and c-di-AMP ... phosphodiesterases. Other advantages of the unique 2'-5' linkage may be that cGAMP is able to bind multiple allelic variants of ... Upon binding DNA, the protein cyclic GMP-AMP Synthase (cGAS) triggers reaction of GTP and ATP to form cyclic GMP-AMP (cGAMP). ... specifically by the cyclic-GMP-AMP synthase (cGAS). Upon DNA recognition, cGAS dimerizes and stimulates the formation of cyclic ...
Phosphodiesterase inhibitor
... inhibition with BAY 73-6691 increases corpus cavernosum relaxations mediated by nitric oxide-cyclic GMP pathway in mice". ... Effects of phosphodiesterase 10 inhibition on striatal cyclic AMP and peripheral physiology in rats; An Torremans, Abdellah ... 2001). "Cyclic nucleotide phosphodiesterases". The Journal of Allergy and Clinical Immunology. 108 (5): 671-80. doi:10.1067/mai ... A phosphodiesterase inhibitor is a drug that blocks one or more of the five subtypes of the enzyme phosphodiesterase (PDE), ...
Phosphodiester bond
... for instance a bond in a molecule of cyclic AMP or cyclic GMP. An enzyme that plays an important role in the repair of ... Phosphodiesterase Phosphodiesterase inhibitor DNA replication, DNA, ATP Teichoic acid, DNase I PDE5 Nick (DNA) "Phosphodiester ... A phosphodiesterase is an enzyme that catalyzes the hydrolysis of phosphodiester bonds, ... Hydrolysis of phosphodiester bonds is catalyzed by phosphodiesterases, which are involved in repairing DNA sequences. The ...
Cyclic-guanylate-specific phosphodiesterase
... c-di-GMP-specific phosphodiesterase, c-di-GMP phosphodiesterase, phosphodiesterase, phosphodiesterase A1, PDEA1, VieA) is an ... Cyclic-guanylate-specific phosphodiesterase (EC 3.1.4.52, cyclic bis(3′→5')diguanylate phosphodiesterase, ... "Identification and characterization of a cyclic di-GMP-specific phosphodiesterase and its allosteric control by GTP". J. Biol. ... Cyclic-guanylate-specific+phosphodiesterase at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Portal: ...
Cyclic nucleotide phosphodiesterase
Kroll S, Phillips WJ, Cerione RA (March 1989). "The regulation of the cyclic GMP phosphodiesterase by the GDP-bound form of the ... cyclic-nucleotide phosphodiesterases (EC 3.1.4.17) are a family of phosphodiesterases. Generally, these enzymes hydrolyze a ... monophosphate phosphodiesterase (cyclic CMP), cyclic 3′,5-nucleotide monophosphate phosphodiesterase, nucleoside 3′,5′-cyclic ... cyclic-nucleotide phosphodiesterases in rod cells are oligomeric, made up of two heavy catalytic subunits, α (90 kDa) and β (85 ...
PRKG1
"Localization of the human gene for the type I cyclic GMP-dependent protein kinase to chromosome 10". Cytogenetics and Cell ... and kinase-directed regulation of phosphorylation of a cGMP-binding phosphodiesterase by cGMP". The Journal of Biological ... 27 (3 Pt 2): 552-7. doi:10.1161/01.hyp.27.3.552. PMID 8613202. Salih E, Zhou HY, Glimcher MJ (Jul 1996). "Phosphorylation of ... 96 (5): 2467-72. Bibcode:1999PNAS...96.2467E. doi:10.1073/pnas.96.5.2467. PMC 26808. PMID 10051666. Wang X, Bruderer S, Rafi Z ...
Sildenafil
... protects cyclic guanosine monophosphate (cGMP) from degradation by cGMP-specific phosphodiesterase type 5 (PDE5) in ... Phosphodiesterase inhibitors (e.g., sildenafil) can also improve [Raynaud's phenomenon] symptoms and ulcer healing Nieto ... Laties AM (January 2009). "Vision disorders and phosphodiesterase type 5 inhibitors: a review of the evidence to date". Drug ... Sildenafil acts by blocking phosphodiesterase 5 (PDE5), an enzyme that promotes breakdown of cGMP, which regulates blood flow ...
Retinitis pigmentosa GTPase regulator
... interacts with the delta subunit of rod cyclic GMP phosphodiesterase". Proceedings of the National Academy of Sciences of the ... interacts with the delta subunit of rod cyclic GMP phosphodiesterase". Proceedings of the National Academy of Sciences of the ... 38 (13): 2750-5. PMID 9418727. Yan D, Swain PK, Breuer D, Tucker RM, Wu W, Fujita R, Rehemtulla A, Burke D, Swaroop A (Jul 1998 ... 5 (7): 1035-41. doi:10.1093/hmg/5.7.1035. PMID 8817343. Murga-Zamalloa CA, Atkins SJ, Peranen J, Swaroop A, Khanna H (Sep 2010 ...
Discovery and development of phosphodiesterase 5 inhibitors
Cyclic GMP binds to the cGMP-dependent protein kinase (PKG1) which phosphorylates several proteins that results in decreased ... Lugnier, C. (2006). "Cyclic nucleotide phosphodiesterase (PDE) superfamily: A new target for the development of specific ... Their function is to degrade intracellular second messengers such as cyclic adenine monophosphate (cAMP) and cyclic guanosine ... GMP is an inactive molecule with no second messenger activity. Phosphorylation of a single serine by PKG1 and the allosteric ...
Guanylate cyclase
... cyclic-GMP-forming)) is a lyase enzyme that converts guanosine triphosphate (GTP) to cyclic guanosine monophosphate (cGMP) and ... Once formed, cGMP can be degraded by phosphodiesterases, which themselves are under different forms of regulation, depending on ... cyclic GMP + diphosphate It is often part of the G protein signaling cascade that is activated by low intracellular calcium ... Adenylyl cyclase Cyclic guanosine monophosphate Guanylyl cyclase activator (protein) Martin, Emil; Berka, Vladimir; Tsai, Ah‐ ...
Riociguat
... reducing cyclic GMP degradation. Endothelin receptor antagonist, another class of drugs used in PAH "Prescription medicines: ... Nitrates and phosphodiesterase inhibitors (including PDE5 inhibitors) increase the hypotensive (blood pressure lowering) effect ... NO binds to soluble guanylate cyclase (sGC) and mediates the synthesis of the secondary messenger cyclic guanosine ... Therefore, the concomitant use of riociguat with phosphodiesterase-5 inhibitors is contraindicated. Cinaciguat, a sGC activator ...
PDE6A
... cyclic phosphodiesterase subunit alpha is an enzyme that in humans is encoded by the PDE6A gene. PDE6A encodes the cyclic-GMP ( ... cGMP) specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 ... "Cryo-EM structure of phosphodiesterase 6 reveals insights into the allosteric regulation of type I phosphodiesterases". Science ... "Entrez Gene: PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha". Gulati S, Palczewski K, Engel A, Stahlberg H, Kovacik L ( ...
List of EC numbers (EC 3)
... cyclic-GMP phosphodiesterase EC 3.1.4.36: Now with EC 3.1.4.43 EC 3.1.4.37: 2′,3′-cyclic-nucleotide 3'-phosphodiesterase EC 3.1 ... phosphodiesterase * EC 3.1.4.59: cyclic-di-AMP phosphodiesterase * EC 3.1.4.60: pApA phosphodiesterase * EC 3.1.4.61: cyclic 2, ... CMP-N-acylneuraminate phosphodiesterase EC 3.1.4.41: sphingomyelin phosphodiesterase D EC 3.1.4.42: glycerol-1,2-cyclic- ... cyclic phosphate phosphodiesterase EC 3.1.4.57: phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase * EC 3.1.4.58: RNA ...
ARL3
Linari M, Hanzal-Bayer M, Becker J (1999). "The delta subunit of rod specific cyclic GMP phosphodiesterase, PDE delta, ... 377 (6547 Suppl): 3-174. PMID 7566098. Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" ... 17 (5): 2476-87. doi:10.1091/mbc.E05-10-0929. PMC 1446103. PMID 16525022. v t e (Articles with short description, Short ... ADP-ribosylation factor-like protein 3 is a protein that in humans is encoded by the ARL3 gene. ADP-ribosylation factor-like 3 ...
PDE6G
"Physical and genetic localization of the gamma subunit of the cyclic GMP phosphodiesterase on the long arm of chromosome 17 ( ... The organization of the gamma-subunit gene of human photoreceptor cyclic GMP phosphodiesterase]" [The organization of the gamma ... of patients with retinitis pigmentosa using a cloned cDNA probe for the human gamma subunit of cyclic GMP phosphodiesterase". ... gene of human photoreceptor cyclic GMP phosphodiesterase]. Doklady Akademii Nauk SSSR. 315 (1): 229-31. PMID 1965799. Tuteja N ...
Papaverine
... but an inhibition of the enzyme phosphodiesterase causing elevation of cyclic AMP and cyclic GMP[clarification needed] levels ... Papaverine has also been demonstrated to be a selective phosphodiesterase inhibitor for the PDE10A subtype found mainly in the ... August 2006). "Inhibition of the striatum-enriched phosphodiesterase PDE10A: a novel approach to the treatment of psychosis". ... Hebb AL, Robertson HA, Denovan-Wright EM (May 2008). "Phosphodiesterase 10A inhibition is associated with locomotor and ...
Phosphodiesterase
... inhibition with BAY 73-6691 increases corpus cavernosum relaxations mediated by nitric oxide-cyclic GMP pathway in mice". ... A phosphodiesterase (PDE) is an enzyme that breaks a phosphodiester bond. Usually, phosphodiesterase refers to cyclic ... "Ontogenetic development of a phosphodiesterase activator and the multiple forms of cyclic AMP phosphodiesterase of rat brain". ... "Differential activation and inhibition of the multiple forms of cyclic nucleotide phosphodiesterase". Advances in Cyclic ...
Cyclic di-AMP
... cyclic guanosine monophosphate (cGMP), guanosine pentaphosphate ((p)ppGpp), and cyclic di-GMP (c-di-GMP). c-di-AMP is a ... Phosphodiesterase (PDE) enzymes degrade cyclic di-AMP to the linear molecule 5'-pApA (phosphadenylyl adenosine). 5'-pApA is ... Cyclic di-GMP Dey B, Dey RJ, Cheung LS, Pokkali S, Guo H, Lee JH, Bishai WR (April 2015). "A bacterial cyclic dinucleotide ... December 2012). "The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a ...
Tadalafil
... which stimulates the synthesis of cyclic guanosine monophosphate (more commonly known as cyclic GMP or cGMP) in smooth muscle ... In 1993, the Bothell, Washington, biotechnology company ICOS Corporation began studying compound IC351, a phosphodiesterase ... The inhibition of phosphodiesterase type 5 (PDE5) enhances erectile function by increasing the amount of cGMP.[medical citation ... "Risk of nonarteritic ischaemic optic neuropathy with phosphodiesterase type 5 inhibitors: a systematic review and meta-analysis ...