5′ flanking region
The 5′ flanking region is a region of DNA that is adjacent to the 5′ end of the gene. The 5′ flanking region contains the ... Flanking SNPs are Single nucleotide polymorphisms (SNP) that appear in the flanking region. Polymorphisms in this region can ... 5′ flanking regions are categorized between prokaryotes and eukaryotes. In eukaryotes, the 5′ flanking region has a complex set ... flanking region of the insulin gene have been associated with type 2 diabetes. Polymorphisms in the 5′ flanking region of the ...
ACTA2
... flanking region of the human aortic smooth muscle actin gene". Nucleic Acids Research. 18 (5): 1318. doi:10.1093/nar/18.5.1318 ... Analysis of a cDNA and 5' upstream region". The Journal of Biological Chemistry. 265 (3): 1683-7. doi:10.1016/S0021-9258(19) ... upstream and first intron regions of the human smooth muscle (aortic type) alpha-actin-encoding gene". Gene. 99 (2): 285-9. doi ... 99 ( Pt 3) (3): 627-36. doi:10.1242/jcs.99.3.627. PMID 1939373. Ueyama H, Ohsugi R (March 1990). "TaqI polymorphism in the 3' ...
UCP3
... flanking region of the human uncoupling protein 3 (UCP3) gene". Biochemical and Biophysical Research Communications. 258 (2): ... Mitochondrial uncoupling protein 3 is a protein that in humans is encoded by the UCP3 gene. The gene is located in chromosome ( ... 86 (3): 372-5. doi:10.1038/sj.bjc.6600074. PMC 2375209. PMID 11875702. Hu X, Murphy F, Karwautz A, Li T, Freeman B, Franklin D ... 47 (3): 425-6. doi:10.1006/geno.1997.5135. PMID 9480760. Vidal-Puig A, Solanes G, Grujic D, Flier JS, Lowell BB (June 1997). " ...
RASD1
... flanking region of this gene allows glucocorticoids to induce expression of RASD1. This protein is a small GTPase belonging to ... flanking region of the human Dexras1 gene". Biochimica et Biophysica Acta. 1627 (2-3): 85-9. doi:10.1016/s0167-4781(03)00079-4 ... As a GTPase, RASD1 also shares motifs, such as in the regions G-1 to G-3, with other GTPases. The full-length RASD1 cDNA ... the phosphate/magnesium binding regions GXXXXGK(S/T) (domain Σ1), DXXG (domain Σ2), and the guanine base binding loops NKXD ( ...
Class III β-tubulin
... flanking region with the interaction of the miR-200c family of micro-RNA. MiR-200c is in turn modulated by the protein HuR ( ... flanking region". Gene. 409 (1-2): 100-8. doi:10.1016/j.gene.2007.11.015. PMID 18178340. Raspaglio G, De Maria I, Filippetti F ... flanking region at +168 nucleotides. This site binds basic helix-loop-helix (bHLH) hypoxia induced transcription factors Hif-1α ... and class III β-tubulin are limited to only 13aa within region 1-429aa, while all amino acids in region 430-450aa are divergent ...
Potato virus Y
Primers bound to the regions flanking the target DNA provide 3'-hydroxyl groups for DNA polymerase catalyzed extension. The ... This means that each newly synthesized strand of DNA will have a region complementary to a primer. There is an exponential ... terminal region (5'-NTR) as well as a 3'-poly-A tail. The positive sense genome contains a single extended open reading frame ... terminal region of potato virus YN RNA. J. Gen. Virol., 70: 229-233. Dallaire, B.J., Charest, P.J., Devantier., Y. and ...
CYP1A2
... nontranslated region, and localization of gene to chromosome 15". Journal of Experimental Pathology. 3 (1): 1-17. PMID 3681487 ... The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region. CYP1A2 also ... 8 (3): 305-313. doi:10.1111/1753-0407.12358. PMID 26621325. Wagner K, Vito S, Inceoglu B, Hammock BD (October 2014). "The role ... doi:10.1210/mend-3-9-1399. PMID 2575218. Butler MA, Iwasaki M, Guengerich FP, Kadlubar FF (October 1989). "Human cytochrome P- ...
Glycoside hydrolase family 42
Shimizu T, Kobayashi T, Ba-Thein W, Ohtani K, Hayashi H (1995). "Sequence analysis of flanking regions of the pfoA gene of ... flanking region". Microbiology and Immunology. 39 (9): 677-86. doi:10.1111/j.1348-0421.1995.tb03256.x. PMID 8577281. S2CID ... 3 (9): 853-9. doi:10.1016/S0969-2126(01)00220-9. PMID 8535779. Henrissat B, Bairoch A (June 1996). "Updating the sequence-based ... Clostridium perfringens: beta-galactosidase gene (pbg) is located in the 3'- ...
TFAP2A
A search of NSCL/P cases for potential regulatory elements for IRF6 gene was made aligning genomic sequences to a 500 Kb region ... flanking IRF6 were screened by direct sequencing for potential causative variants in 184 NSCL/P cases. The rare allele of the ... Sequencing of candidate genes in that region in 4 additional unrelated BOFS patients revealed 4 different de novo missense ... Human sequence as reference and searched for multispecies conserved sequences (MCSs). Regions contained in introns 5' and 3' ...
Wayne M. Becker
... flanking regions of the NADH-dependent hydroxypyruvate reductase gene from Cucumis sativus L". Plant Molecular Biology. 28 (5 ... 103 (3): 933-941. doi:10.1104/pp.103.3.933. PMC 159066. PMID 8022942. Sloan, J. S.; B. W. Schwartz; W. M. Becker (1993). " ... 3 (6): 867-874. doi:10.1111/j.1365-313X.1993.00867.x. "Wayne Becker , Fulbright Scholar Program". "Professor Wayne M. Becker". ... Daniel, S.G.; W.M. Becker (1995). "Transgenic analysis of the 5' and 3'- ...
DIO2
2000). "Characterization of the 5'-flanking and 5'-untranslated regions of the cyclic adenosine 3',5'-monophosphate-responsive ... untranslated region of human type 2 iodothyronine deiodinase mRNA contains a functional selenocysteine insertion sequence ... The 3' UTR of Sec-containing genes have a common stem-loop structure, the Sec insertion sequence (SECIS), which is necessary ... 144 (3): 937-946. doi:10.1210/en.2002-220960. PMID 12586771. Ambroziak M, Pachucki J, Chojnowski K, et al. (2003). "Pax-8 ...
FUT2
... flanking region of the human ABO-secretor gene (FUT2) and association between FUT2 and FUT2/01 loci". Hum. Biol. 76 (5): 789-95 ... 1995). "Molecular cloning of a human genomic region containing the H blood group alpha(1,2)fucosyltransferase gene and two H ... 34 (3): 314-8. PMID 15487706. Pang H, Soejima M, Koda Y, Kimura H (2005). "A novel tetrameric short tandem repeat located in ... 246 (3): 750-5. doi:10.1111/j.1432-1033.1997.t01-1-00750.x. PMID 9219535. Koda Y; Soejima M; Johnson PH; et al. (1997). " ...
Directionality (molecular biology)
The 5′-flanking region of a gene often denotes a region of DNA which is not transcribed into RNA. The 5′-flanking region ... flanking region is a region of DNA that is not copied into the mature mRNA, but which is present adjacent to 3′-end of the gene ... The 5′-untranslated region (5′-UTR) is a region of a gene which is transcribed into mRNA, and is located at the 5′-end of the ... flanking region often contains sequences that affect the formation of the 3′-end of the message. It may also contain enhancers ...
Beta-globin co-transcriptional cleavage ribozyme
... flanking region of the beta-globin gene. The CoTC core is highly conserved in the 3' UTR of other primate beta-globin genes. ... The CoTC process in the human beta-globin gene was proposed to involve an RNA self-cleaving activity located in the 3' ...
List of MeSH codes (G14)
... flanking region MeSH G14.340.024.340.137.295 - 5' flanking region MeSH G14.340.024.340.137.430 - immunoglobulin switch region ... flanking region MeSH G14.340.024.220.282 - 5' flanking region MeSH G14.340.024.220.400 - introns MeSH G14.340.024.220.760 - ... locus control region MeSH G14.080.689.650 - operator regions (genetics) MeSH G14.080.689.675 - promoter regions (genetics) MeSH ... locus control region MeSH G14.340.024.630 - nucleolus organizer region MeSH G14.340.024.686 - operon MeSH G14.340.024.686.545 ...
CLOCK
... flanking region and morning/evening preference in adults found a correlation between subjects with the 3111C allele and ... This region is well conserved between mice and humans and polymorphisms have been shown to affect mRNA stability, indicating ... It was found that in women with breast cancer, there was significantly less methylation of the Clock promoter region. It was ... Polymorphisms in the gene mainly affect the length of the PolyQ domain region, providing an example of divergent evolution ...
Index of molecular biology articles
... flanking region - 3-hydroxy-2-methylpyridinecarboxylate dioxygenase - 3-Ketosteroid 9alpha-monooxygenase - 3-oxoacyl-(acyl- ... flanking region - 5-pyridoxate dioxygenase - 6-endo-hydroxycineole dehydrogenase - 7-deoxyloganin 7-hydroxylase - 7beta- ... beta-carotene 3-hydroxylase - beta-cyclopiazonate dehydrogenase - beta-glucan-transporting ATPase - beta2-adaptin C-terminal ... juglone 3-monooxygenase - junk DNA - k+-transporting ATPase - karyotype - KduI/IolB isomerase family - kilobase - kinase - ...
Gene structure
Only the region between the start and stop codons encodes the final protein product. The flanking untranslated regions (UTRs) ... Indeed, the intron regions of a gene can be considerably longer than the exon regions. Once spliced together, the exons form a ... These sequence regions can either be next to the transcribed region (the promoter) or separated by many kilobases (enhancers ... Exon regions are retained in the final mature mRNA molecule, while intron regions are spliced out (excised) during post- ...
SARS-related coronavirus
The SARS-CoV genome is ~29.7 kb long and contains 14 open reading frames (ORFs) flanked by 5′ and 3′-untranslated regions of ... 19 (3): 141-154. doi:10.1038/s41579-020-00459-7. PMC 7537588. PMID 33024307. Zhou H, Ji J, Chen X, Bi Y, Li J, Wang Q, et al. ( ... 35 (3): 1313-1326. doi:10.21873/invivo.12384. PMC 8193286. PMID 33910809. Lu R, Zhao X, Li J, Niu P, Yang B, Wu H; et al. (2020 ... 8 (3: The COVID Crisis and Cultural Sociology: Alone Together): 451-461. doi:10.1057/s41290-020-00118-7. eISSN 2049-7121. ISSN ...
Reynders
The form Reinders is more common in the Eastern Netherlands and the flanking regions of Germany.[3] The Dutch given name ...
DNA vaccine
Additionally, flanking regions outside this immunostimulatory hexamer must be guanine-rich to ensure binding and uptake into ... Accessory regions pertaining to the plasmid backbone may engage in a wide range of structural instability phenomena. Well-known ... Because these proteins contain regions of amino acid sequences that are characteristic of bacteria or viruses, they are ... The optimal immunostimulatory sequence is an unmethylated CpG dinucleotide flanked by two 5' purines and two 3' pyrimidines. ...
Calpain-3
... interacts with the extreme C-terminal region of connectin, a unique region flanked by two immunoglobulin C2 motifs". Arch. ... Calpain-3 is a protein that in humans is encoded by the CAPN3 gene. Calpain, a heterodimer consisting of a large and a small ... Huang Y, de Morrée A, van Remoortere A, Bushby K, Frants RR, den Dunnen JT, van der Maarel SM (2008). "Calpain 3 is a modulator ... 61 (1): 231-3. doi:10.1016/S0002-9297(07)64296-7. PMC 1715865. PMID 9246005. Dinçer P, Leturcq F, Richard I, Piccolo F, ...
Lassen Peak
Helens, which had a volume of 0.24 cu mi (1.0 km3). The region on the volcano's northeastern flank destroyed by the eruptions, ... Within the region, most if not all of the volcanic rock has erupted in the past 3 million years. During this period, at least ... No lava erupted, but parts of the dome fell on the upper flanks of the mountain, which were covered in more than 30 ft (9.1 m) ... The region is also affected geologically by the Cascadia subduction zone, which dips eastward beneath the western coast of ...
Kupe orthonairovirus
There is a non coding regions: the 5′ region of 40 nt and the 3′ region of 137 nt. This open reading frame encodes several ... The M segment RNA is 4,818 nucleotides in length and contains one open reading frame flanked by 5′ and 3′ non coding regions of ... It contains a unique potential N-gly site in the Gn and Gc glycoprotein regions at amino acids 612 and 1514 respectively. The S ... noncoding regions are 49 nt and 193 nt in length respectively. "Virus Taxonomy: 2020 Release". International Committee on ...
CELA1
... flanking region". Journal of Biochemistry. 101 (3): 591-9. doi:10.1093/jb/101.3.591. PMID 3648024. Kawashima I, Tani T, Mita- ... 44 (1): 210-3. doi:10.1023/A:1026691209094. PMID 9952246. S2CID 1137506. Borowitz D, Baker SS, Duffy L, Baker RD, Fitzpatrick L ... 44 (1): 210-3. doi:10.1023/A:1026691209094. PMID 9952246. S2CID 1137506. Gullo L, Ventrucci M, Tomassetti P, Migliori M, ... 145 (3): 322-6. doi:10.1016/j.jpeds.2004.04.049. PMID 15343184. Edelstein C, Italia JA, Scanu AM (April 1997). " ...
ADAMTS4
Mizui Y, Yamazaki K, Kuboi Y, Sagane K, Tanaka I (Sep 2000). "Characterization of 5'-flanking region of human aggrecanase-1 ( ... Adjacent to the C-terminal TSR is a disintegrin-like domain, a cysteine-rich region that stacks against the active-site of the ... Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a ... 5 (3): 169-76. doi:10.1093/dnares/5.3.169. PMID 9734811. Tortorella MD, Burn TC, Pratta MA, Abbaszade I, Hollis JM, Liu R, ...
E-box
Apr 2013). "Genomic Regions Flanking E-Box Binding Sites Influence DNA Binding Specificity of bHLH Transcription Factors ... The CT-Rich Regions (CTRR) located about 23 nucleotides upstream of the E-box is important in E-box binding, transactivation ( ... Besides, each bHLH monomer has a basic region, which helps mediate recognition between the bHLH monomer and the E-box (the ... Furthermore, the sequence constraints on the region around the circadian E-box are not fully understood: it is believed to be ...
Corticotropin-releasing hormone
Vamvakopoulos NC, Chrousos GP (1994). "Structural organization of the 5' flanking region of the human corticotropin releasing ... "Structural analysis of the regulatory region of the human corticotropin releasing hormone gene". FEBS Letters. 267 (1): 1-5. ... 47 (3): 113-116. doi:10.1159/000132525. PMID 3259914. Sasaki A, Tempst P, Liotta AS, Margioris AN, Hood LE, Kent SB, et al. ( ... Retrieved 3 August 2008. Lye S, Challis JR (2001). "Chapter 12: Parturition". In Bocking AD, Harding R (eds.). Fetal growth and ...
Syndecan 1
... core protein is mediated by a novel structural motif in the transmembrane domain and ectodomain flanking region". The Journal ... which contains two constant regions that are separated by a variable region. The extracellular domain can be cleaved (shed) ... cleaves off heparan sulfate to expose a binding site in the N-terminal region of syndecan-1's core protein. Three SDC1 elements ... "The mapping and visual ordering of the human syndecan-1 and N-myc genes near the telomeric region of chromosome 2p". Human ...
Pleiotrophin
... core protein is mediated by a novel structural motif in the transmembrane domain and ectodomain flanking region". J. Biol. Chem ... Promoter region and chromosomal localization". J. Biol. Chem. 267 (36): 26011-6. doi:10.1016/S0021-9258(18)35709-0. PMID ... Asundi VK, Carey DJ (1995). "Self-association of N-syndecan (syndecan-3) ... syndecan-3)". J. Biol. Chem. 269 (17): 12999-3004. doi:10.1016/S0021-9258(18)99975-8. PMID 8175719. Fabri L, Maruta H, ...