Marcus PI; Talalay P (1956). "Induction and purification of alpha- and beta-hydroxysteroid dehydrogenases". J. Biol. Chem. 218 ... In enzymology, a 3alpha-hydroxysteroid dehydrogenase (B-specific) (EC 1.1.1.50) is an enzyme that catalyzes the chemical ... B-specific). Other names in common use include hydroxyprostaglandin dehydrogenase, 3alpha-hydroxysteroid oxidoreductase, and ... more specifically it is part of the group of hydroxysteroid dehydrogenases. The systematic name of this enzyme class is 3alpha- ...

HNF-1 alpha, and vHNF-1 regulate the cell-specific expression of the human dihydrodiol dehydrogenase (DD)4/AKR1C4 gene". ... of 3alpha-hydroxysteroid/dihydrodiol dehydrogenase in human liver". Pharmacogenetics. 9 (6): 763-71. doi:10.1097/00008571- ... "Close kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes". Genes to Cells. 5 (2): ... "Hepatocyte nuclear factor-4 alpha/gamma and hepatocyte nuclear factor-1 alpha as causal factors of interindividual difference ...

In enzymology, a 3alpha-hydroxysteroid dehydrogenase (A-specific) (EC 1.1.1.213) is an enzyme that catalyzes the chemical ... The systematic name of this enzyme class is 3alpha-hydroxysteroid:NAD(P)+ oxidoreductase (A-specific). As of late 2007, 11 ... Tomkins GM (1956). "A mammalian 3alpha-hydroxysteroid dehydrogenase". J. Biol. Chem. 218 (1): 437-447. PMID 13278351. Portal: ... more specifically it is part of the group of hydroxysteroid dehydrogenases. ...

Aldo-keto reductase family 1 member C3 (AKR1C3), also known as 17β-hydroxysteroid dehydrogenase type 5 (17β-HSD5, HSD17B5) is a ... Khanna M, Qin KN, Wang RW, Cheng KC (Aug 1995). "Substrate specificity, gene structure, and tissue-specific distribution of ... Rheault P, Dufort I, Soucy P, Luu-The V (1999). "Assignment of HSD17B5 encoding type 5 17 beta-hydroxysteroid dehydrogenase to ... "Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional ...

May 2005). "Role of photoreceptor-specific retinol dehydrogenase in the retinoid cycle in vivo". J. Biol. Chem. 280 (19): 18822 ... Some retinol dehydrogenases are in extra-ocular tissues, such as human retinol dehydrogenase-4 (RoDH-4), which converts retinol ... One of the widely studied genes of retinol dehydrogenase RDH12, which encodes retinol dehydrogenase is part of the superfamily ... retinal pigment epithelial-specific 11-cis retinol dehydrogenase belongs to the family of short chain alcohol dehydrogenases". ...

Couture JF, Legrand P, Cantin L, Luu-The V, Labrie F, Breton R (Aug 2003). "Human 20alpha-hydroxysteroid dehydrogenase: ... "Entrez Gene: AKR1C1 aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid ... O'connor T, Ireland LS, Harrison DJ, Hayes JD (Oct 1999). "Major differences exist in the function and tissue-specific ... Zhang Y, Dufort I, Rheault P, Luu-The V (Oct 2000). "Characterization of a human 20alpha-hydroxysteroid dehydrogenase". Journal ...

October 2004). "11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response". Endocrine ... 11 alpha-Hydroxyprogesterone (11 alpha OH-P) was an order of magnitude more potent a competitive inhibitor of the 11 beta HSD-2 ... Souness GW, Morris DJ (March 1996). "11 alpha- and 11 beta-hydroxyprogesterone, potent inhibitors of 11 beta-hydroxysteroid ... of 11β-hydroxysteroid dehydrogenase (11β-HSD). It is notably not metabolized by 11β-HSD2. 11α-OHP is a more potent inhibitor of ...

... in vitro induction of 20 alpha-hydroxysteroid dehydrogenase in splenic lymphocytes from athymic mice by a unique lymphokine". J ... It also has many more specific effects like the regeneration of platelets and potentially aids in early antibody isotype ... that it induced the synthesis of 20alpha-hydroxysteroid dehydrogenase in hematopoietic cells and termed it interleukin-3 (IL-3 ... The human IL-3 gene is located on chromosome 5, only 9 kilobases from the GM-CSF gene, and its function is quite similar to GM- ...

Moghrabi N, Head JR, Andersson S (Nov 1997). "Cell type-specific expression of 17 beta-hydroxysteroid dehydrogenase type 2 in ... variations in levels of 17 beta-hydroxysteroid dehydrogenase type 2 and 5 alpha-reductase activity compatible with androgen ... 17β-Hydroxysteroid dehydrogenase 2 (17β-HSD2) is an enzyme of the 17β-hydroxysteroid dehydrogenase (17β-HSD) family that in ... a microsomal enzyme possessing 20 alpha-hydroxysteroid dehydrogenase activity". The Journal of Biological Chemistry. 268 (17): ...

In accordance, 11α- and 11β-hydroxyprogesterone are known to be potent inhibitors of 11β-hydroxysteroid dehydrogenase (11β-HSD ... Souness GW, Morris DJ (1996). "11 alpha- and 11 beta-hydroxyprogesterone, potent inhibitors of 11 beta-hydroxysteroid ... However, formebolone was found to be a very weak inhibitor of 11β-HSD type 2, although this specific isoenzyme is responsible ... potent inhibitors of 11 beta-hydroxysteroid dehydrogenase (isoforms 1 and 2), confer marked mineralocorticoid activity on ...

17β-Hydroxysteroid dehydrogenase deficiency - A condition characterized by impaired androgen and estrogen synthesis in males ... 5α-reductase deficiency (5-ARD) - An autosomal recessive condition caused by a mutation of the 5-alpha reductase type 2 gene. ... Legato MJ (2017-05-15). Principles of Gender-Specific Medicine: Gender in the Genomic Era. Academic Press. p. 38. ISBN 978-0-12 ... "17β-Hydroxysteroid dehydrogenase 3 deficiency: Three case reports and a systematic review". The Journal of Steroid Biochemistry ...

Liang T, Liao S (July 1992). "Inhibition of steroid 5 alpha-reductase by specific aliphatic unsaturated fatty acids". The ... "Comparison of the effects of new specific azasteroid inhibitors of steroid 5 alpha-reductase on canine hyperplastic prostate: ... 17 alpha-hydroxylase/C17-20-lyase) and 5 alpha-reductase types 1 and 2". Journal of Medicinal Chemistry. 43 (22): 4266-77. doi: ... a novel compound with alpha 1-adrenoceptor antagonistic and steroid 5 alpha-reductase inhibitory actions: pharmacological ...

... formed by the 20α-hydroxysteroid dehydrogenases (20α-HSDs) AKR1C1, AKR1C2, and AKR1C3 and the 17β-hydroxysteroid dehydrogenase ... Nowak FV (April 2002). "Distribution and metabolism of 20 alpha-hydroxylated progestins in the female rat". J. Steroid Biochem ... 4-. ISBN 978-1-4200-7745-2. Marianne J. Legato (29 October 2009). Principles of Gender-Specific Medicine. Academic Press. pp. ... Casey ML, MacDonald PC, Andersson S (November 1994). "17 beta-Hydroxysteroid dehydrogenase type 2: chromosomal assignment and ...

Homeobox protein DLX-3 is a protein that in humans is encoded by the DLX3 gene. Dlx3 is a crucial regulator of hair follicle ... 7 (3): 563-9. doi:10.1093/hmg/7.3.563. PMID 9467018. Roberson MS, Meermann S, Morasso MI, et al. (2001). "A role for the ... 38 (3): 314-24. doi:10.1006/geno.1996.0634. PMID 8975708. Price JA, Bowden DW, Wright JT, et al. (1998). "Identification of a ... 145 (3): 1096-105. doi:10.1210/en.2003-0777. PMID 14670999. Haldeman RJ, Cooper LF, Hart TC, et al. (2005). "Increased bone ...

... factor-5 and a GATA-like protein determine placental-specific expression of the Type I human 3beta-hydroxysteroid dehydrogenase ... is a transcriptional activator in alpha 1-adrenergic agonist-stimulated cardiac myocytes". The Journal of Biological Chemistry ... "Entrez Gene: TEAD3 TEA domain family member 3". Bürglin, TR (Jul 1991). "The TEA domain: a novel, highly conserved DNA-binding ...

Each zone is responsible for producing specific hormones. It is also a secondary site of androgen synthesis. The adrenal cortex ... 17-alpha-hydroxyprogesterone → (hydroxylation at C21) → 11-Deoxycortisol → (hydroxylation at C11) → Cortisol The adrenal cortex ... The zona glomerulosa cells express a specific enzyme aldosterone synthase (also known as CYP11B2). Aldosterone is largely ... The expression of neuron-specific proteins in the zona glomerulosa cells of human adrenocortical tissues has been predicted and ...

"Chalcones are potent inhibitors of aromatase and 17beta-hydroxysteroid dehydrogenase activities". Life Sciences. 68 (7): 751-61 ... The gene has nine coding exons and a number of alternative non-coding first exons that regulate tissue specific expression. ... Om AS, Chung KW (April 1996). "Dietary zinc deficiency alters 5 alpha-reduction and aromatization of testosterone and androgen ... Aromatase is localized in the endoplasmic reticulum where it is regulated by tissue-specific promoters that are in turn ...

20 beta-hydroxysteroid dehydrogenase by a licorice-derived steroidal inhibitor". Structure. 2 (10): 973-80. doi:10.1016/S0969- ... has arisen through gene fusion of a common ancestral coenzyme nucleotide sequence with various substrate specific domains. ... Glucose/ribitol dehydrogenase InterPro: IPR002347 Insect alcohol dehydrogenase family InterPro: IPR002424 2,3-dihydro-2,3- ... alcohol dehydrogenases. Most members of this family are proteins of about 250 to 300 amino acid residues. Most dehydrogenases ...

2005). "A novel somatic mutation of the 3beta-hydroxysteroid dehydrogenase gene in sporadic cutaneous verruciform xanthoma". ... Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating is an enzyme that in humans is encoded by the NSDHL gene. This ... Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788-95 ... encoding a 3beta-hydroxysteroid dehydrogenase, cause CHILD syndrome". Am J Med Genet. 90 (4): 339-46. doi:10.1002/(SICI)1096- ...

"11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response". Endocrine Reviews. 25 (5 ... 5-alpha THF) and 5-beta tetrahydrocortisol (5-beta THF), reactions for which 5-alpha reductase and 5-beta-reductase are the ... "Hexose-6-phosphate dehydrogenase determines the reaction direction of 11beta-hydroxysteroid dehydrogenase type 1 as an ... and activity of the cortisol-activating enzyme 11β-hydroxysteroid dehydrogenase type 1 is tissue and species-specific". Chemico ...

Souness GW, Morris DJ (1996). "11 alpha- and 11 beta-hydroxyprogesterone, potent inhibitors of 11 beta-hydroxysteroid ... are known to be potent inhibitors of 11β-hydroxysteroid dehydrogenase (11β-HSD), which is responsible for the biosynthesis of ... although this specific isoenzyme of 11β-HSD is responsible for the inactivation of glucocorticoids rather than their production ... potent inhibitors of 11 beta-hydroxysteroid dehydrogenase (isoforms 1 and 2), confer marked mineralocorticoid activity on ...

The reductive pathways are by 11β-hydroxysteroid dehydrogenase type 1 in the liver and AKR7A2/AKR7A3 in the intestine leading ... The alpha position adjacent to the ketone is first brominated followed by nucleophilic displacement of the resulting alpha- ... "Antidepressants for non-specific low back pain". The Cochrane Database of Systematic Reviews. 2008 (1): CD001703. doi:10.1002/ ... Chen WC, Lai HC, Su WP, Palani M, Su KP (January 2015). "Bupropion for interferon-alpha-induced depression in patients with ...

... include autosomal recessive disorders with mutations lowering the activity of the enzyme 11-beta-hydroxysteroid dehydrogenase ... Deficiency of 17-alpha-hydroxylase blocks the conversion of pregnenolone and progesterone to their 17-a-hydroxy forms leading ... In some cases, specific antihypertensive medications may be recommended. In Liddle's syndrome, ENaC-binding potassium-sparing ... Specific treatment of pseudohyperaldosteronism depends on the inciting cause. General management focuses on countering the ...

The gene has these neighbors on chromosome 9: HSDL2: Hydroxysteroid dehydrogenase-like protein 2 plays a role in nucleotide ... Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific ... According to this tool, the protein's secondary structure is a combination of alpha helices and beta sheets, in almost equal ... KIAA1958 was also overexpressed in Stat5/ab and stat 3 which are transcription factors reported to be critical for the growth ...

3alpha-hydroxyglycyrrhetinate dehydrogenase - 4932414N04Rik - 3alpha-hydroxysteroid dehydrogenase (A-specific) - 3alpha,7alpha, ... coproporphyrinogen dehydrogenase - cortisone alpha-reductase - cosmid - costunolide synthase - CpG - craniosynostosis - crp ... 7beta-hydroxysteroid dehydrogenase (NADP+) - 8-oxocoformycin reductase - 12beta-hydroxysteroid dehydrogenase - 25- ... B-specific) - 2-methylacyl-CoA dehydrogenase - 2-nitropropane dioxygenase - 2-oxobutyrate synthase - (2,3-dihydroxybenzoyl) ...

... specifically with local expression at the skin of reductive 17β-hydroxysteroid dehydrogenase, and oxidative 3α-hydroxysteroid ... 2012). "The 5 alpha-reductase isozyme family: a review of basic biology and their role in human diseases". Adv. Urol. 2012: ... Specific substrates include testosterone, progesterone, androstenedione, epitestosterone, cortisol, aldosterone, and ... Wang J, Zhao S, Luo L, Li E, Li X, Zhao Z (2018). "5-alpha Reductase Inhibitors and risk of male breast cancer: a systematic ...

... and then finally converted to testosterone by 17β-hydroxysteroid dehydrogenase (HSD17B). The onset of puberty is controlled by ... labeled alpha- and beta- subunits) that are non-covalently associated: The alpha subunits of LH, FSH, TSH, and hCG are ... LH has a beta subunit of 120 amino acids (LHB) that confers its specific biologic action and is responsible for the specificity ... The gene for the alpha subunit is located on chromosome 6q12.21. The luteinizing hormone beta subunit gene is localized in the ...

Her team was the first to publish mutations on the 11β-hydroxysteroid dehydrogenase type 2 enzyme (encoded by the HSD11B2 gene ... President's Council of Cornell Women Alpha Omega Alpha, University of Pennsylvania School of Medicine New York Practitioner's ... to study specific steroid hormone production during infancy, childhood and adolescence.[citation needed] In 1964, New was ... New was first to identify the mild form with specific molecular mutations. New has received numerous honors, including: IPSEN ...

This appears to be due to a decrease in hepatic 17β-hydroxysteroid dehydrogenase type 2 (17β-HSD2) activity and hence estradiol ... Estradiol is an estrogen, or an agonist of the estrogen receptors (ERs), the ERαTooltip estrogen receptor alpha and ERβTooltip ... which results in slower absorption rates with specific formulations of the drug such as vaginal tablets. Estradiol hemihydrate ... It was also originally known as dihydroxyestrin, dihydrofolliculin, or alpha-estradiol. Estradiol was first introduced for ...

Estrone can also be converted by 17β-hydroxysteroid dehydrogenases into the more potent estrogen estradiol. E1S levels are much ... Instead, estrone sulfate is transported into cells in a tissue-specific manner by active transport via organic-anion- ... "Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta". ... For this reason, enzyme inhibitors of steroid sulfatase and 17β-hydroxysteroid dehydrogenase and inhibitors of OATPs, which ...

Hepatic metabolism is mediated by 11 beta-hydroxysteroid dehydrogenases (11[beta]-HSD) and 20-ketosteroid reductases. ... A specific example is the deacetylation by histone deacetylase 2 (HDACe) was necessary for transrepression of NF-κB. The ... alpha]-hydroxymethylprednisolone. The primary use of methylprednisolone is to suppress inflammatory and immune responses. ... Specific immune functions effected by this process are cytokinesis, migration, phagocytosis, antigen processing and presenting ...