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"Exogenous Sodium Pyruvate Stimulates Adipogenesis of 3T3-L1 Cells". Journal of Cellular Biochemistry. 117 (1): 39-48. doi: ... In the body, one way in which sodium pyruvate provides energy to cells is through pyruvate conversion to acetyl-CoA which then ... It is commonly added to cell culture media as an additional source of energy, but may also have protective effects against ... sodium pyruvate has been used in many experiments involving cell cultures to provide more energy. In adipocytes it was found ...
... induces mitochondrial impairment in 3T3-L1 adipocytes". Mol. Cell. Biochem. 340 (1-2): 41-8. doi:10.1007/s11010-010-0398-5. ... domain that stimulates 3T3-L1 preadipocytes proliferation". Gene. 379: 132-40. doi:10.1016/j.gene.2006.05.008. PMID 16815647. ... "Over-expression of NYGGF4 inhibits glucose transport in 3T3-L1 adipocytes via attenuated phosphorylation of IRS-1 and Akt". ... effects on insulin resistance are reversed by metformin in 3T3-L1 adipocytes". J. Bioenerg. Biomembr. 44 (6): 665-71. doi: ...
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explored 3T3-L1 adipocytes cocultured with RAW264.7 cells to examine this potential interaction. RAW264.7 coculture increases ... There was also a GPR84 downregulation in dentritic cell derived from FcRgamma chain KO mice. In microglial cells, the GPR84 ... EST clones corresponding to hgpr84 were from B cells (leukemia), neuroendocrine lung as well as in microglial cells and ... Ly6G + MDSCs in Lal-/- mice show strong immunosuppression on T cells, which contributes to impaired T cell proliferation and ...
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In 3T3-L1 adipocytes, OGA inhibition with PUGNAc inhibited insulin-mediated glucose uptake. PUGNAc treatment also inhibited ... cells. PDAC cells have some dependency upon O-GlcNAc for survival as OGT knockdown selectively inhibited PDAC cell ... In a mouse model, mice injected with cells expressing PFK1 S529A mutant showed lower tumor growth than mice injected with cells ... This effect was not observed in proliferating cells and undifferentiated myoblastic cells. AMPK phosphorylation of OGT T444 has ...
In vitro studies on differentiation have used the pre-committed preadipocyte lineage, such as 3T3-L1 and 3T3-F442A cell line, ... Green H, Kehinde O (28 February 1974). "Sublines of mouse 3T3 cells that accumulate lipid". Cell. 1 (3): 113-116. doi:10.1016/ ... PPARγ is necessary and sufficient to promote fat cell differentiation. PPARγ is required for embryonic stem cells (ES cells) ... "Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells". Genes & Development. 5 (9): 1538-52. ...
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"Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells". Genes & Development. 5 (9): 1538-1552 ... Mo X, Kowenz-Leutz E, Xu H, Leutz A (January 2004). "Ras induces mediator complex exchange on C/EBP beta". Molecular Cell. 13 ( ... Davydov IV, Krammer PH, Li-Weber M (December 1995). "Nuclear factor-IL6 activates the human IL-4 promoter in T cells". Journal ... CEBP-beta is critical for normal macrophage functioning, an important immune cell sub-type; mice unable to express CEBP-beta ...
Cao Z, Umek RM, McKnight SL (Sep 1991). "Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells ... CEBPD is involved in regulation of apoptosis and cell proliferation. It probably acts as tumor suppressor. One study in mice ... Cell Biology. 29 (12): 1525-39. doi:10.1016/S1357-2725(97)00083-6. PMID 9570146. Zhu Y, Saunders MA, Yeh H, Deng WG, Wu KK (Mar ... Cytogenetics and Cell Genetics. 70 (3-4): 188-91. doi:10.1159/000134030. PMID 7789168. Cleutjens CB, van Eekelen CC, van Dekken ...
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Cao Z, Umek RM, McKnight SL (Sep 1991). "Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells ... In contrast, ectopic expression of C/EBPβ and δ in 3T3-L1 preadipocytes promotes adipogenesis, even in the absence of ... Cell culture studies in mice and human microglia lines also find increased C/EBPβ activity associated with pathogenic ... C/EBPβ plays a role in neuronal differentiation, in learning, in memory processes, in glial and neuronal cell functions, and in ...
"Identification of novel putative membrane proteins selectively expressed during adipose conversion of 3T3-L1 cells". ... and also on the cell membrane, which indicates that MC2 needs MRAP to reach the cell membrane. In addition to cell trafficking ... MRAP mutations were found to disable the movement of MC2 to the cell surface of adrenal gland cells; this would make MC2 ... In fat cells, where MC2 is expressed, MRAP was found to facilitate MC2 activated lipolysis and therefore regulating energy ...
"APS facilitates c-Cbl tyrosine phosphorylation and GLUT4 translocation in response to insulin in 3T3-L1 adipocytes". Molecular ... and vinculin-binding protein localized at cell-cell and cell-matrix adherens junctions". The Journal of Cell Biology. 144 (5): ... In non-muscle cells, it inhibits cell spreading and focal adhesion turnover, as its siRNA-mediated knockdown resulted in ... multifuntional c-Cbl binding protein in insulin receptor signaling in 3T3-L1 adipocytes". Molecular and Cellular Biology. 18 (2 ...
1,25-(OH)2D3 transiently but strongly induces Insig-2 expression in 3T3-L1 cells. This novel regulatory circuit may also play ... Ka SO, Kim KA, Kwon KB, Park JW, Park BH (May 2009). "Silibinin attenuates adipogenesis in 3T3-L1 preadipocytes through a ... a functional vitamin D response element in the murine Insig-2 promoter and its potential role in the differentiation of 3T3-L1 ... March 2009). "Activation of PPARalpha and PPARgamma reduces triacylglycerol synthesis in rat hepatoma cells by reduction of ...
Choi BH, Kim YH, Ahn IS, Ha JH, Byun JM, Do MS (2009). "The inhibition of inflammatory molecule expression on 3T3-L1 adipocytes ... The exact mechanism of regulation is unknown, but adiponectin could be regulated by post-translational mechanisms in cells. A ... Adiponectin was first characterised in 1995 in differentiating 3T3-L1 adipocytes (Scherer PE et al.). In 1996 it was ... In 2007, adiponectin was identified as a transcript highly expressed in preadipocytes (precursors of fat cells) differentiating ...
June 2015). "Nonivamide enhances miRNA let-7d expression and decreases adipogenesis PPARγ expression in 3T3-L1 cells". Journal ... July 2015). "Evaluation of the antitumour activity of Rinvanil and Phenylacetylrinvanil on the cervical cancer tumour cell ... oleoresin loaded mixed micelles enhances in vitro cytotoxicity on MCF-7 cells and in vivo anticancer activity against DAL cells ... "Antineoplastic activity of rinvanil and phenylacetylrinvanil in leukaemia cell lines". Oncology Letters. 7 (5): 1651-1656. doi: ...
Expression of E1 alpha mRNA and subunit in maple-syrup-urine-disease and 3T3-L1 cells". The Journal of Biological Chemistry. ... The BCKD enzyme complex can be found in the mitochondria, an organelle known as the powerhouse of the cell. All three amino ... When these byproducts start to accumulate it produces a toxic environment for cells and tissues, specifically in the nervous ... Cytogenetics and Cell Genetics. 50 (4): 236-7. doi:10.1159/000132768. PMID 2805821. Fisher CW, Chuang JL, Griffin TA, Lau KS, ...
October 2013). "Insulin responsiveness of glucose transporter 4 in 3T3-L1 cells depends on the presence of sortilin". Molecular ... As a sorting receptor on the cell surface and on the endoplasmic reticulum-Golgi apparatus within the cell, sortilin is ... as it has been detected in several cancer cell lines. Notably, human cancerous epithelial cells exhibited increased levels of ... In humans, sortilin is expressed over a wide range of cell types and tissues such as the brain, spinal cord, adrenal gland, ...
... is a sub clonal cell line derived from the original 3T3 Swiss albino cell line of 1962. The 3T3 original cell line was ... While some protocols promote the process of adipogenesis in 3T3-L1 cells, others reduce or inhibit the process. In 3T3-L1 ... "3T3-L1 Cell Line". Retrieved 22 July 2018. Green, Howard; Kehinde, Olaniyi (March 1974). "Sublines of mouse 3T3 cells that ... some literature suggests some phenotypic 3T3-L1 characteristics can resemble that of brown adipocytes. 3T3-L1 cells, when ...
"ArPIKfyve-PIKfyve interaction and role in insulin-regulated GLUT4 translocation and glucose transport in 3T3-L1 adipocytes". ... PIKfyve inhibitors cause cell death also in A-375 melanoma cells, which depend on autophagy for growth and proliferation, due ... Cell. 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573. (Articles with short description, Short ... "PIKfyve regulates CaV1.2 degradation and prevents excitotoxic cell death". The Journal of Cell Biology. 187 (2): 279-94. doi: ...
"Role of EHD1 and EHBP1 in perinuclear sorting and insulin-regulated GLUT4 recycling in 3T3-L1 adipocytes". J. Biol. Chem. 279 ( ... Cell. 15 (5): 2410-22. doi:10.1091/mbc.E03-10-0733. PMC 404033. PMID 15020713. Guilherme A, Soriano NA, Furcinitti PS, Czech MP ... doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573. v t e (Articles with short description, Short description matches ... 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635-48. ...
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... induces enlargement of the 3D organoid of 3T3-L1 cells". Scientific Reports. 10 (1): 16018. Bibcode:2020NatSR..1016018I. doi: ...
"ArPIKfyve-PIKfyve interaction and role in insulin-regulated GLUT4 translocation and glucose transport in 3T3-L1 adipocytes". ... ArPIKfyve facilitates insulin-regulated GLUT4 translocation to the cell surface. VAC14 knock-out mice die at, or shortly after ... These organelles play critical roles in vesicular trafficking, which move cargo from donor membrane cells to target membranes ... Experimental Cell Research. 313 (11): 2404-2416. doi:10.1016/j.yexcr.2007.03.024. PMC 2475679. PMID 17475247. Zhang Y, Zolov SN ...
891 and GW9508 stimulated 3T3-L1 mouse stem-like cells to mature into fat cells; 3) mice lacking a functional ffar4 gene (i.e ... taste bud cells, fat cells, respiratory epithelium cells in the lung (i.e., club cells also termed clara cells), and ... The two forms of fat cells, i.e., white and brown fat cells, develop from precursor stem cells. Brown fat cells promote ... cells in brain, heart, and liver tissues, skeletal muscle cells, blood vessel endothelial cells, enteroendocrine L cells of the ...
"Anti-obesity property of lichen Thamnolia vermicularis extract in 3T3-L1 cells and diet-induced obese mice". Preventive ...
"APS Facilitates c-Cbl Tyrosine Phosphorylation and GLUT4 Translocation in Response to Insulin in 3T3-L1 Adipocytes". Mol. Cell ... In Burkitt lymphoma cell lines, it is tyrosine phosphorylated in response to B cell receptor stimulation. Because it binds Shc ... has a negative regulatory role in B cell proliferation". Biochem. Biophys. Res. Commun. 330 (3): 1005-13. doi:10.1016/j.bbrc. ... an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor stimulation". Oncogene. ...
Studies with 3T3-L1 cells have shown chemerin expression is low in pre-differentiated adipocytes but its expression and ... Studies using mature human adipocytes, 3T3-L1 cells, and in vivo studies in mice showed chemerin stimulates the phosphorylation ... It was found incubation of 3T3-L1 cells with recombinant human chemerin protein facilitated insulin-stimulated glucose uptake. ... "Chemerin enhances insulin signaling and potentiates insulin-stimulated glucose uptake in 3T3-L1 adipocytes". FEBS Lett. 582 (5 ...