"Dichotomous Expression of TNF Superfamily Ligands on Antigen-Presenting Cells Controls Post-priming Anti-viral CD4+ T Cell ... DeBenedette, M. A.; Shahinian, A.; Mak, T. W.; Watts, T. H. (1997). "Costimulation of CD28- T lymphocytes by 4-1BB ligand". ...
The CD137/ligand complex is also involved in regulation of the immune system. The CD137 ligand is a type-II transmembrane ... CD137/ligand stimulation has been found to lead to stronger anti-tumor responses due to cytotoxic T cell activation and is ... The CD137 ligand is normally expressed at low levels, but can have increased expression in presence of pathogen associated ... When CD137 then reacts with the CD137 ligand, it leads to CD137 upregulation. This is a form of self regulation or positive ...
Its ligand is ICOSL, expressed mainly on B cells and dendritic cells. The molecule seems to be important in T cell effector ... The ligand for GITR is mainly expressed on antigen presenting cells. Antibodies to GITR have been shown to promote an anti- ... PD-1: short for Programmed Death 1 (PD-1) receptor, has two ligands, PD-L1 and PD-L2. This checkpoint is the target of Merck & ... Binding with its two ligands are CD80 and CD86, expressed on dendritic cells, prompts T cell expansion. CD28 was the target of ...
"Costimulation as a platform for the development of vaccines: a peptide-based vaccine containing a novel form of 4-1BB ligand ...
Binding of the B7 of APC to CTLA-4 of T-cells causes inhibition of the activity of T-cells. There are two major types of B7 ... The B7-CTLA-4 binding suppresses T cell activation. The balance between the opposing signals generated by B7-CD28 and B7-CTLA-4 ... In the TNF family of molecules, the protein 4-1BB (CD137) on the T cell may bind to 4-1BB ligand (4-1BBL) on the APC. The B7 ( ... CTLA-4-knockout mice are unable to stop immune responses, and develop a fatal massive lymphocyte proliferation. Apart from B7-1 ...
Tumor necrosis factor ligand superfamily member 9 also known as 4-1BB ligand or 4-1BBL or CD137L is a protein that in humans is ... Ligand at the U.S. National Library of Medicine Medical Subject Headings (MeSH) v t e (Articles with short description, Short ... The link with 4-1BBL is largely made up of amino acids from the dynamic loops of the CRD2 and the β sheet of CRD3 of 4-1BB, ... The 4-1BB/4-1BBL complex consists of three monomeric 4-1BBs bound to a trimeric 4-1BBL. Each 4-1BB monomer binds to two 4-1BBLs ...
... ligand binding, CD137 agonist immunoglobulin‐γ 4 (IgG4) monoclonal antibody. It was developed utilizing Medarex's UltiMAb(R) ... 19 (4): 1040-1051. doi:10.1158/1535-7163.MCT-19-0608. PMID 31974274. S2CID 210882192. Qi X, Li F, Wu Y, Cheng C, Han P, Wang J ... Urelumab targets the extracellular domain of CD137 (4-1BB). CD137 is a co-stimulatory molecule that's a member of the tumor ... September 2022). "A humanized 4-1BB-targeting agonistic antibody exerts potent antitumor activity in colorectal cancer without ...
OX40L is the ligand for OX40 (also known as CD134 or TNFRSF4) and is stably expressed on many antigen-presenting cells such as ... Stüber E, Neurath M, Calderhead D, Fell HP, Strober W (May 1995). "Cross-linking of OX40 ligand, a member of the TNF/NGF ... February 2008). "Expression of OX40 ligand in microglia activated by IFN-gamma sustains a protective CD4+ T-cell response in ... April 2004). "Detection and characterization of OX40 ligand expression in human airway smooth muscle cells: a possible role in ...
Wickham, Thomas J. (2003). "Ligand-directed targeting of genes to the site of disease". Nature Medicine. 9 (1): 135-9. doi: ... fused to a natural ligand for a cell-surface receptor. The use of adapter molecules has been shown to increase viral ... "Growth Inhibition of Human Multiple Myeloma Cells by an Oncolytic Adenovirus Carrying the CD40 Ligand Transgene". Clinical ... 9 (4): 138-141. doi:10.1016/0168-9525(93)90209-Z. PMID 8516849. Levine, A. (1997). "P53, the Cellular Gatekeeper for Growth and ...
... is one of the most studied ligands for HAVCR2 (TIM-3) and is expressed on various tumor cells. However, it can also ... "The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity". Nature Immunology. 6 (12): 1245-52. doi:10.1038/ ... "Tumor necrosis factor-related apoptosis-inducing ligand activates a lysosomal pathway of apoptosis that is regulated by Bcl-2 ... "A highly conserved tyrosine of Tim-3 is phosphorylated upon stimulation by its ligand galectin-9". Biochemical and Biophysical ...
This can include cytokines, such is IL-2, IL-5, IL-12 and co‐stimulatory ligands. Adding a synthetic control mechanism to ... 1BB). The intracellular signaling domain used defines the generation of a CAR T cell. First generation CARs include only a CD3- ... 1BB. The involvement of these intracellular signaling domains improve T cell proliferation, cytokine secretion, resistance to ... usually taking advantage of ligand/receptor pairs that normally bind to each other. Cytokines, innate immune receptors, TNF ...
It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. When CD27 binds ... 10 (4): 427-36. doi:10.1038/ni.1717. PMC 4167721. PMID 19270712. Prasad KV, Ao Z, Yoon Y, Wu MX, Rizk M, Jacquot S, Schlossman ... 13 (11): 4-15. Sánchez MJ, Holmes A, Miles C, Dzierzak E (December 1996). "Characterization of the first definitive ... Sturgill ER (November 2017). "TNFR agonists: a review of current biologics targeting OX40, 4-1BB, CD27, and GITR". American ...
... its ligand, OX40L, is also not expressed on resting antigen presenting cells, but is following their activation. Expression of ... which as a TLR9 ligand activates expression of OX40 so that it can be affected. CD134 has been shown to interact with TRAF5 and ... CTLA-4 is down-regulated following OX40 engagement in vivo and the OX40-specific TRAF3 DN defect was partially overcome by CTLA ... TRAF3 may be linked to OX40-mediated memory T cell expansion and survival, and point to the down-regulation of CTLA-4 as a ...
1BB. Additionally, with the approval of the several new bsAb since 2022, and new mechanisms for improving efficacy like ... achieved through the mediation of BsAb to inactivate either the RTKs or their ligand, reduces the possibility of the escape ... to interfere with receptor signaling and inactivate signaling ligands, and to force association of protein complexes. BsAbs ... Other popular targets are CD3, HER2, PD-1, PD-L1, EGFR, CTLA-4, etc., which as well as immune targets of PD-1, PD-L1, BCMA, ...
The encoded protein and its ligand play a role in the development and organization of lymphoid tissue and transformed cells. ... 28 (4): 169-75. doi:10.1016/j.it.2007.02.005. PMID 17336158. Browning JL, Ngam-ek A, Lawton P, et al. (1993). "Lymphotoxin beta ... 271 (25): 14661-4. doi:10.1074/jbc.271.25.14661. PMID 8663299. Matsumoto M, Hsieh TY, Zhu N, et al. (1997). "Hepatitis C virus ... 1998). "TRAF-4 expression in epithelial progenitor cells. Analysis in normal adult, fetal, and tumor tissues". Am. J. Pathol. ...
... due to ligand-defective apo B; 144010; APOB Hypercholesterolemia, familial; 143890; LDLR Hypercholesterolemia, familial, 3; ... 1BB; 612877; DSG2 Cardiomyopathy, dilated, 1CC; 613122; NEXN Cardiomyopathy, dilated, 1D; 601494; TNNT2 Cardiomyopathy, dilated ... 4; 604352; GPR98 COPD, rate of decline of lung function in; 606963; MMP1 Coproporphyria; 121300; CPOX Cornea plana congenita, ... KRAS Noonan syndrome 4; 610733; SOS1 Noonan syndrome 5; 611553; RAF1 Noonan syndrome 6; 613224; NRAS Noonan-like syndrome with ...
Binding of a ligand to a monomeric receptor tyrosine kinase stabilizes interactions between two monomers to form a dimer, after ... 147 (4): 934-946. doi:10.1016/j.cell.2011.08.052. PMC 3220604. PMID 22078888. Holt LJ, Tuch BB, Villén J, Johnson AD, Gygi SP, ... Over the last 4 years, dozens of studies have been published, each identifying thousands of sites, many of which were ... 37 (Pt 4): 627-641. doi:10.1042/BST0370627. ISSN 1470-8752. PMID 19614568. Rogakou EP, Pilch DR, Orr AH, Ivanova VS, Bonner WM ...