... are a class of vitamin K antagonist (VKA) anticoagulant drug molecules derived from coumarin by adding a ... Although 4-hydroxycoumarin itself is not an anticoagulant, it is an important fungal metabolite from the precursor coumarin, ... 4-hydroxycoumarins at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Synthesis (4-Hydroxycoumarins, ... The primary mechanism of the 4-hydroxycoumarin drugs is the inhibition of vitamin K epoxide reductase. These compounds are not ...
Finally, enolate 4 abstracts a proton from protonated base (or solvent) to produce 5. The reaction is dominated by orbital, ... 4, p. 776 McMurry, J. E.; Melton, J. (1988). "Conversion of Nitro to Carbonyl by Ozonolysis of Nitronates: 2,5-Heptanedione". ... 4, p. 630 Moffett, R. B. (1963). "Methyl γ-Methyl-γ-nitrovalerate". Organic Syntheses.; Collective Volume, vol. 4, p. 652 ... The terms oxa-Michael reaction and aza-Michael reaction have been used to refer to the 1,4-addition of oxygen and nitrogen ...
also in the Collective Volume (1963) 4: 478 (PDF)). Jain, P. K.; Makrandi, J. K. (1982). "A Facile Baker-Venkataraman Synthesis ... Kalinin, A.V.; Sneckus, V. (1998). "4,6-Dimethoxy-3,7-dimethylcoumarin from Colchicum decaisnei. Total synthesis by carbamoyl ... Regiospecific route to substituted 4-hydroxycoumarins". Tetrahedron Letters. 39 (28): 4995-4998. doi:10.1016/S0040-4039(98) ...
East AJ, Ollis WD, Wheeler RE (1969). "Natural occurrence of 3-aryl-4-hydroxycoumarins. Part I. Phytochemical examination of ...
East AJ, Ollis WD, Wheeler RE (1969). "Natural occurrence of 3-aryl-4-hydroxycoumarins. Part I. Phytochemical examination of ...
4-hydroxycoumarins are a type of vitamin K antagonist. They block the regeneration and recycling of vitamin K. These chemicals ... Some of the 4-hydroxycoumarin anticoagulant class of chemicals are designed to have high potency and long residence times in ... 135 (4): 2157-2162. doi:10.1016/j.foodchem.2012.07.083. hdl:2158/775163. PMID 22980784. S2CID 14467019. Hatano, T.; et al. ( ... 37 (4): 423-453. doi:10.1016/S0278-6915(99)00010-1. PMID 10418958. "Frequently Asked Questions about coumarin in cinnamon and ...
The MK-4 form is from conversion of plant-sourced vitamin K1 in various tissues in the body. Because vitamin K aids mechanisms ... Animals may also convert it to vitamin K2, variant MK-4. Bacteria in the gut flora can also convert K1 into K2. All forms of K2 ... One subset, 4-hydroxycoumarins, act as vitamin K antagonists. They block the regeneration and recycling of vitamin K. Some of ... The two most studied ones are menaquinone-4 (MK-4) and menaquinone-7 (MK-7). Vitamin K1 is made by plants, and is found in ...
Section 3.1.4. Retrieved 21 June 2017. Sean C Sweetman, ed. (2009). Martindale: The Complete Drug Reference (36th ed.). London ... For a more complete list of coumarins used as pharmaceuticals and rodenticides, see the main article on 4-hydroxycoumarins. ... The vitamin K antagonists can cause birth defects (teratogens). Coumarins (more accurately 4-hydroxycoumarins) are the most ...
... is a coumarin derivative with a hydroxy group at the 4-position. 4-Hydroxycoumarin is an important fungal ... 4-Hydroxycoumarin is biosynthesized from malonyl-CoA and 2-hydroxybenzoyl-CoA by the enzyme 4-hydroxycoumarin synthase. After ... 4-Hydroxycoumarin forms the core of the chemical structure of anticoagulants known collectively as 4-hydroxycoumarins. They ... Liu, B.; Raeth, T.; Beuerle, T. & Beerhues, L. (2010). "A novel 4-hydroxycoumarin biosynthetic pathway". Plant Mol. Biol. 72 (1 ...
175 (4): 461-468. doi:10.1111/j.0954-6820.1964.tb00594.x. ISSN 0954-6820. PMID 14149651. Schäfer, F. P., ed. (1990). Dye Lasers ... 4-Phenylcoumarin is the backbone of the neoflavones, a type of neoflavonoids. Coumarin pyrazole hybrids have been synthesized ... 4 April 2019. Retrieved 13 April 2019. "Coumarins and indandiones". Drugs.com. 2016. Retrieved 24 December 2016. "Warfarin". ... This occurs as the result of the production of 4-hydroxycoumarin, then further (in the presence of naturally occurring ...
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4,5-tetrahydro-8-chloro-3-methyl-5-phenyl-1h-3-benzazepin-7-ol MeSH D03.438.079.800 - 2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl ... 4,5-dihydro-1-(3-(trifluoromethyl)phenyl)-1h-pyrazol-3-amine MeSH D03.383.129.539.200 - epirizole MeSH D03.383.129.539.487 - ... 4-oxadiazole MeSH D03.383.312.649.290 - fanft MeSH D03.383.312.649.308 - furagin MeSH D03.383.312.649.313 - furazolidone MeSH ... 4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, methyl ester MeSH D03.383.725.210 - dimethindene MeSH D03.383. ...
4-Hydroxycoumarins, All stub articles, Blood and blood forming organ drug stubs). ...
... , a 4-hydroxycoumarin structurally similar to warfarin, is a white to off-white crystalline powder with a ... Lovenox 4.000 IE (40 mg)/0,4 ml Injektionslösung in einer Fertigspritze. Entry on Phenprocoumon. at: Römpp Online. Georg Thieme ...
It is a second-generation 4-hydroxycoumarin derivative and vitamin K antagonist, often called a "super-warfarin" for its added ...
51 (4): 561-74. doi:10.1177/0091270010370588. PMID 20622200. S2CID 36344392. Albrecht D, Turakhia MP, Ries D, Marbury T, Smith ... 117 (4): 706-717. doi:10.1160/TH16-08-0623. PMID 28180234. S2CID 4356089. Spreitzer H (27 February 2017). "Neue Wirkstoffe - ... 4-Hydroxycoumarins, All stub articles, Blood and blood forming organ drug stubs). ...
... is an anticoagulant of the 4-hydroxycoumarin vitamin K antagonist type. It has anticoagulant effects and is used ...
... is a 4-hydroxycoumarin anticoagulant, with a similar mode of action to its historical predecessors dicoumarol and ... 24 (2): 202-4. doi:10.1097/mbc.0b013e328358e959. PMID 23358203. La Rosa F; Clarke S; Lefkowitz J B (1997). "Brodifacoum ... In another case reported in 2013, a 48-year-old female patient reported 4 days of mild dyspnea, dry cough, bilateral popliteal ... Brodifacoum is a derivative of the 4-hydroxy-coumarin group. Compounds numbers are found next to their respective compounds in ...
... is an anticoagulant of the 4-hydroxycoumarin vitamin K antagonist type used as a rodenticide. Coumatetralyl is ...
... is a fluorinated, second-generation anticoagulant of the 4-hydroxycoumarin vitamin K antagonist type. It is a ...
Like all 4-hydroxycoumarin drugs it is a competitive inhibitor of vitamin K epoxide reductase, an enzyme that recycles vitamin ... Identified in 1940, dicoumarol became the prototype of the 4-hydroxycoumarin anticoagulant drug class. Dicoumarol itself, for a ... and other 4-hydroxycoumarin drugs. It is given orally, and it acts within two days. Dicoumarol was used, along with heparin, ...
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