Gunsior M, Ravel J, Challis GL, Townsend CA (Jan 2004). "Engineering p-hydroxyphenylpyruvate dioxygenase to a p- ... also known as α-ketoisocaproate dioxygenase (KIC dioxygenase), is an Fe(II)-containing non-heme oxygenase that catalyzes the ... Knox WE, LeMay-Knox M (October 1951). "The oxidation in liver of l-tyrosine to acetoacetate through p-hydroxyphenylpyruvate and ... A model for the action of p-hydroxyphenylpyruvate hydroxylase". Journal of the American Chemical Society. 97 (18): 5272-7. doi: ...

These results suggested that p-hydroxyphenylpyruvate dioxygenase (HPPD) was the enzyme that was inhibited, a fact which was ... The Discovery and Structural Requirements of Inhibitors of p-hydroxyphenylpyruvate Dioxygenase. Weed Science,45(5),p.601-609 (9 ... He furthermore found that the urine of rats treated with III showed elevated levels of both p-hydroxyphenylpyruvate and p- ... The 4-methylsulfonyl group was then prepared to test this hypothesis, and what was to become the commercial herbicide Mikado ( ...

... pyruvate dioxygenase with the specific inhibitor 2-[2-nitro-4-(trifluoromethyl)benzoyl]-1,3-cyclohexanedione". Biochemistry. 42 ... Alkaptonuria is caused when an enzyme called homogentisic dioxygenase (HGD) is faulty, leading to a buildup of homogenisate. ... Ellis MK, Whitfield AC, Gowans LA, Auton TR, Provan WM, Lock EA, Smith LL (July 1995). "Inhibition of 4-hydroxyphenylpyruvate ... dioxygenase by 2-(2-nitro-4-trifluoromethylbenzoyl)-cyclohexane-1,3-dione and 2-(2-chloro-4-methanesulfonylbenzoyl)-cyclohexane ...

4 (2): 1-41. doi:10.1300/J144V04N02_01. ISSN 1092-678X. S2CID 129756850. Wikidata Q111370060. Dayan, Franck E.; Owens, Daniel K ... 68 (4): 519-528. doi:10.1002/ps.2332. PMID 22232033. Mesotrione in the Pesticide Properties DataBase (PPDB) (CS1 errors: ... 1,3-Cyclohexanedione is first reacted with the acid chloride of 4-(methylsulfonyl)-2-nitrobenzoic acid under conditions in ... doi:10.1007/978-94-011-4173-4_7. ISBN 978-94-010-5817-9. Derek Cornes (2005). "Callisto: a very successful maize herbicide ...

2,4,5-T was withdrawn from use in the US in 1983, at a time of heightened public sensitivity about chemical hazards in the ... 146 (4): 579-600. doi:10.1111/j.1474-919X.2004.00375.x. Robbins, C.S.; Dowell, B.A.; Dawson, D.K.; Colon, J.A.; Estrada, R.; ... 2,4-D (2,4-dichlorophenoxy acetic acid)is a broadleaf herbicide in the phenoxy group used in turf and no-till field crop ... It was a 50/50 mixture of the n-butyl esters of 2,4,5-T and 2,4-D. Because of TCDD contamination in the 2,4,5-T component, it ...

Additionally, 4-HPPA can be converted to homogentisic acid which is one of the precursors to ochronotic pigment. It is an ... 4-Hydroxyphenylpyruvic acid (4-HPPA) is an intermediate in the metabolism of the amino acid phenylalanine. The aromatic side ... 4-Hydroxyphenylpyruvate dioxygenase Brand, Larry; Harper, Alfred (1974). "Effect of glucagon on phenylalanine metabolism and ... Denoya, Claudio; Skinner, Deborah; Morgenstern, Margaret (September 1994). "A Streptomyces avermitilis gene encoding a 4- ...

The cytosolic dioxygenase has been characterized extensively and differs from the mitochondrial form in that the dioxygenase ... The cytosolic dioxygenase has been characterized extensively and differs from the mitochondrial form in that the dioxygenase ... In the first, HMB is produced from [α-KIC] by the cytosolic enzyme KIC dioxygenase (Sabourin and Bieber 1983). ... In the first, HMB is produced from [α-KIC] by the cytosolic enzyme KIC dioxygenase (Sabourin and Bieber 1983). ...

The intermediate then spontaneously reacts with glutathione to form 2-L-cystein-S-yl-1,4-dihydroxy-cyclohex-5-en-1-yl acetic ... Normally, the breakdown of the amino acid tyrosine involves the conversion of 4-hydroxyphenylpyruvate to homogentisate by 4- ... hydroxyphenylpyruvate dioxygenase. Complete deficiency of this enzyme would lead to tyrosinemia III. In rare cases, however, ... 4-Hydroxyphenylpyruvate dioxygenase Danks, D. M.; Tippett, P; Rogers, J (1975). "A new form of prolonged transient tyrosinemia ...

... involvement of an unusual dioxygenase in the pathway to (S)-4-hydroxyphenylglycine". J. Am. Chem. Soc. 122 (22): 5389-5390. doi ... In enzymology, a 4-hydroxymandelate synthase (EC 1.13.11.46) is an enzyme that catalyzes the chemical reaction 4- ... hydroxyphenylpyruvate + O2 ⇌ {\displaystyle \rightleftharpoons } 4-hydroxymandelate + CO2 Thus, the two substrates of this ... The systematic name of this enzyme class is 4-hydroxyphenylpyruvate:oxygen oxidoreductase (decarboxylating). This enzyme is ...

Knox WE, LeMay-Knox M (October 1951). "The oxidation in liver of l-tyrosine to acetoacetate through p-hydroxyphenylpyruvate and ... If active and present, the enzyme homogentisate 1,2-dioxygenase further degrades homogentisic acid to yield 4-maleylacetoacetic ... 2-dioxygenase (typically due to a mutation) in the degradative pathway of tyrosine, consequently associated with alkaptonuria. ... 4-Hydroxyphenylpyruvate (produced by transamination of tyrosine) is acted upon by the enzyme 4-hydroxyphenylpyruvate ...

18 (4): 641-651. doi:10.1007/s00792-014-0645-x. ISSN 1433-4909. PMID 24794033. S2CID 13898874. Rajput, Rinky; Verma, Ved Vrat; ... "Structural and functional characterization of 4-hydroxyphenylpyruvate dioxygenase from the thermoacidophilic archaeon ...

... is a rare disorder caused by a deficiency of the enzyme 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27 ... Specifically, 4-hydroxyphenylpyruvate dioxygenase converts a tyrosine byproduct called 4-hydroxyphenylpyruvate to homogentisic ...

Given the important biological roles that αKG-dependent dioxygenase play, many αKG-dependent dioxygenase inhibitors were ... All αKG-dependent dioxygenases contain a conserved double-stranded β-helix (DSBH, also known as cupin) fold, which is formed ... Many αKG-dependent dioxygenase also catalyse uncoupled turnover, in which oxidative decarboxylation of αKG into succinate and ... αKG-dependent dioxygenases catalyse oxidation reactions by incorporating a single oxygen atom from molecular oxygen (O2) into ...

doi:10.1007/978-94-011-4173-4_7. ISBN 978-94-010-5817-9. Achkar J, Xian M, Zhao H, Frost JW (2005). "Biosynthesis of ... "Herbicidal 4-hydroxyphenylpyruvate dioxygenase inhibitors -- A review of the triketone chemistry story from a Syngenta ...

It is a 4-hydroxyphenylpyruvate dioxygenase inhibitor indicated for the treatment of hereditary tyrosinemia type 1 (HT-1) in ... 5 (1): 1-4. doi:10.1177/2326409817744230. Retrieved 12 March 2019. Grompe M (2016-12-20). "Disorders of Tyrosine Metabolism". ... Type III tyrosinemia results from a mutation in the HPD gene, which encodes the enzyme 4-hydroxyphenylpyruvate dioxygenase. ...

It is supplied orally as a capsule or suspension in dose increments of 2 mg, 5 mg, 10 mg, or 20 mg or 4 mg/mL respectively. The ... She proposed that the metabolic defect in this patient was a deficiency of 4-hydroxyphenylpyruvate dioxygenase, but her case ... 4-hydrooxyphenylpyruvate dioxygenase functions to convert 4-hydroxyphenylpyruvate to homogentisate as the second enzymatic ... In 1965, doubts emerged that the underlying biochemical cause of hepatorenal tyrosinemia was a defective form of the 4- ...

... including 4-hydroxyphenylpyruvate dioxygenase and the tetrahydrobiopterin dependent hydroxylases. The name NIH shift arises ...

... may refer to: 4-hydroxyphenylpyruvate dioxygenase 4-hydroxymandelate synthase ...

Among these alleles, 4 were obtained from lines collected before the use of DDT and so it is unlikely that the G171K change ... 26 (4): 460-7. doi:10.3109/14756366.2010.526769. PMID 21028940. S2CID 41391243. Douglas KT (1987). "Mechanism of action of ... 113 (4-5): 234-58. doi:10.1080/13813450701661198. PMID 18158646. S2CID 35240599. Board PG (May 2011). "The omega-class ... Most mammalian isoenzymes have affinity for the substrate 1-chloro-2,4-dinitrobenzene, and spectrophotometric assays utilising ...

KIC dioxygenase), which converts α-KIC to HMB. In healthy individuals, this minor pathway - which involves the conversion of L- ... In other words, racemic 4-methylpentane-1,2,4-triol is a derivative of 2-methylpent-4-en-2-ol and β-hydroxy β-methylbutyric ... A relatively small amount of α-KIC is metabolized in the liver by the cytosolic enzyme 4-hydroxyphenylpyruvate dioxygenase ( ... Depending on the experimental conditions, cycloaddition of acetone and ketene produces either β-isovalerolactone or 4,4- ...

... pyruvate dioxygenase. He is an expert in magnetic circular dichroism spectroscopy. Elucidation of the tyrosinase dicopper ... These include copper-containing enzymes such as azurin, plastocyanin and laccase, as well as non-heme iron enzymes such as (4- ... Solomon, Edward I.; McClure, Donald S. (1972-09-01). "Jahn-Teller Effect in the $^{4}T_{1g}(I)$ State of ${\mathrm{Mn}}^{++}$ ...

... a 4-hydroxyphenylpyruvate dioxygenase inhibitor Hours per patient-day, a staffing goal to determine the number of clinicians ... a perception disorder that can be caused by hallucinogenic drug use 4-hydroxyphenylpyruvate dioxygenase, an enzyme found in ...

EC 1.14.12 Nitric oxide dioxygenase Category:EC 1.14.13 Nitric oxide synthase EC 1.14.13.39 Category:EC 1.14.14 Aromatase EC ... EC 1.6.4 now Category:EC 1.8.1 Category:EC 1.6.5 (with a quinone or similar compound as acceptor) NADH dehydrogenase EC 1.6.5.3 ... EC 1.1.4 (with a disulfide as acceptor) Category:EC 1.1.5 (with a quinone or similar compound as acceptor) Category:EC 1.1.99 ( ... EC 1.5.4 (with a disulfide as acceptor) Category:EC 1.5.5 (with a quinone or similar compound as acceptor) Category:EC 1.5.7 ( ...

2-dioxygenase, catechol 2,3-dioxygenase, 3,4-dihydroxyphenylacetate 2,3-dioxygenase and 4-hydroxyphenylpyruvate dioxygenase all ... 3-demethylubiquinone-9 3-O-methyltransferase and numerous dioxygenases such as biphenyl-2,3-diol 1, ... 170 (4): 209-18. doi:10.1007/s002030050635. PMID 9732434. S2CID 21289561. Oya T, Hattori N, Mizuno Y, Miyata S, Maeda S, Osawa ... 27 (4): 565-573. doi:10.1016/0306-3623(95)02054-3. PMID 8853285. Ariza A, Vickers TJ, Greig N, Armour KA, Dixon MJ, Eggleston ...

... may refer to: 4-Hydroxyphenylpyruvate dioxygenase Hematoporphyrin, organic compound Histrionic personality disorder Honda ...

2-dioxygenase (HGD), phenylalanine-4-hydroxylase (PAH), maleylacetoacetate isomerase (GSTZ1),and other amino acid catabolic ... 4 (2): 319-20. doi:10.1093/hmg/4.2.319. PMID 7757089. Kato S, Sekine S, Oh SW, Kim NS, Umezawa Y, Abe N, Yokoyama-Kobayashi M, ... 90 (4): 1185-92. doi:10.1172/JCI115979. PMC 443158. PMID 1401056. Mohamed S, Kambal MA, Al Jurayyan NA, Al-Nemri A, Babiker A, ... 9 (4): 291-9. doi:10.1002/(SICI)1098-1004(1997)9:4. 3.0.CO;2-9. PMID 9101289. S2CID 21881874. Phaneuf D, Lambert M, Laframboise ...

4 (3): 319-33. doi:10.1089/10906570050501588. PMID 11142767. Montgomery KT, Lee E, Miller A, Lau S, Shim C, Decker J, Chiu D, ... 76 (4): 647-51. doi:10.1086/429226. PMC 1199301. PMID 15714404. Genome Decoration Page, NCBI. Ideogram data for Homo sapience ( ... Chromosome 12 spans about 133 million base pairs (the building material of DNA) and represents between 4 and 4.5 percent of the ... Cytoskeleton associated protein 4 CNOT2: encoding protein CCR4-NOT transcription complex subunit 2 CNPY2: encoding protein ...

2-dioxygenase MeSH D08.811.682.690.416.305 - catechol 2,3-dioxygenase MeSH D08.811.682.690.416.319 - cysteine dioxygenase MeSH ... 2-oxoglutarate 5-dioxygenase MeSH D08.811.682.690.708.673 - procollagen-proline dioxygenase MeSH D08.811.682.690.708.715 - ... gamma-butyrobetaine dioxygenase MeSH D08.811.682.690.708.410 - heme oxygenase (decyclizing) MeSH D08.811.682.690.708.410.500 - ... 3-dioxygenase MeSH D08.811.682.690.416.444 - lipoxygenase MeSH D08.811.682.690.416.444.050 - arachidonate lipoxygenases MeSH ...

4HmaS is a non-heme iron-dependent dioxygenase. The reaction mechanism of this unique oxidation was proposed by Choroba et al ... Involvement of an Unusual Dioxygenase in the Pathway to (S)-4-Hydroxyphenylglycine." J. Am. Chem. Soc. 2000, 122, 5389-5390. Li ... 4-Hydroxyphenylglycine (HPG) is a non-proteogenic amino acid found in vancomycin and related glycopeptides. HPG is synthesized ... 4-Hydroxyphenylpyruvate is then oxidized by 4-hydroxymandelate synthase (4HmaS) using oxygen to form 4-hydroxymandelate and ...

3-dioxygenase EC 1.13.11.17: indole 2,3-dioxygenase EC 1.13.11.18: persulfide dioxygenase EC 1.13.11.19: cysteamine dioxygenase ... 2-dioxygenase EC 1.13.11.38: 1-hydroxy-2-naphthoate 1,2-dioxygenase EC 1.13.11.39: biphenyl-2,3-diol 1,2-dioxygenase EC 1.13. ... dioxygenase EC 1.14.11.4: procollagen-lysine 5-dioxygenase EC 1.14.11.5: Now included with EC 1.14.11.6 thymine dioxygenase EC ... peptide-aspartate β-dioxygenase EC 1.14.11.17: taurine dioxygenase EC 1.14.11.18: phytanoyl-CoA dioxygenase EC 1.14.11.19: Now ...