How FLAP activates 5-lipooxygenase is not completely understood, but there is a physical interaction between the two.[citation ... It is an integral protein within the nuclear membrane. FLAP is necessary in synthesis of leukotriene, which are lipid mediators ... Leukotrienes, which require the FLAP protein to be synthesized, have an established pathological role in allergic and ... is a protein that in humans is encoded by the ALOX5AP gene. FLAP is necessary for the activation of 5-lipoxygenase and ...

This protein is involved in the production of cysteinyl leukotrienes which are involved in inflammation, and AM-679 has anti- ... Part 2: 3-{5-((S)-1-Acetyl-2,3-dihydro-1H-indol-2-ylmethoxy)-3-tert-butylsulfanyl-1-[4-(5-methoxy-pyrimidin-2-yl)-benzyl]-1H- ... Musiyenko, A.; Correa, L.; Stock, N.; Hutchinson, J. H.; Lorrain, D. S.; Bain, G.; Evans, J. F.; Barik, S. (2009). "A Novel 5- ... Lipoxygenase-Activating Protein Inhibitor, AM679, Reduces Inflammation in the Respiratory Syncytial Virus-Infected Mouse Eye". ...

... and/or 271 by mitogen-activated protein kinases, S6 kinase, protein kinase A (PKA), protein kinase C, Cdc2, and/or a Ca2+/ ... ALOX5 binds with the F actin-binding protein, coactin-like protein. Based on in vitro studies, this protein binding serves to ... This chemotactic factor stimulation concurrently causes the activation of mitogen-activated protein kinases (MAPK) which in ... Coactin-like protein (COL1), and Dicer protein A PLAT domain within its C2-like domain; this domain, by analogy to other PLAT ...

Squalene oxidation activates NF-κB (a protein complex) and consequently increases IL-1α levels. Additionally, squalene ... LTB4 promotes skin inflammation by acting on the peroxisome proliferator-activated receptor alpha (PPARα) protein. PPARα ... Once the light activates the sensitizing substance, this generates free radicals and reactive oxygen species in the skin, which ... Milk contains whey protein and hormones such as bovine IGF-1 and precursors of dihydrotestosterone. Studies suggest these ...

"Inhibition of five lipoxygenase activating protein (FLAP) by MK-886 decreases atherosclerosis in apoE/LDLR-double knockout mice ... Jun, Joon-Il; Lau, Lester F. (July 2010). "The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis ... It may perform this by blocking the 5-lipoxygenase activating protein (FLAP), thus inhibiting 5-lipoxygenase (5-LOX), and may ...

"Inhibition of five lipoxygenase activating protein (FLAP) by MK-886 decreases atherosclerosis in apoE/LDLR-double knockout mice ... strong downregulation of CXCR3 expression on activated T cells, and downregulation of matrix metalloproteinase 9 expression ... Examples of 5-LOX inhibitors include drugs, such as meclofenamate sodium and zileuton. Some chemicals found in trace amounts in ... 188 (5): 538-544. doi:10.1164/rccm.201301-0023PP. PMID 23822826. Singh, Rakesh Kumar; Tandon, Ruchi; Dastidar, Sunanda Ghosh; ...

When such cells are activated, arachidonic acid is liberated from cell membrane phospholipids by phospholipase A2, and donated ... The lipoxygenase pathway is active in leukocytes and other immunocompetent cells, including mast cells, eosinophils, ... Leukotrienes act principally on a subfamily of G protein-coupled receptors. They may also act upon peroxisome proliferator- ... activated receptors. Leukotrienes are involved in asthmatic and allergic reactions and act to sustain inflammatory reactions. ...

Other lipoxygenases-8-LO, 12-LO, and 15-LO-make other eicosanoid-like products. To act, 5-LO uses the nuclear-membrane enzyme 5 ... lipoxygenase-activating protein (FLAP), first to a hydroperoxyeicosatetraenoic acid (HPETE), then to the first leukotriene, LTA ... They activate phospholipids to release AA as a free fatty acid from neuron cell membranes. [citation needed] Free AA may affect ... Lipoxygenase oxidation removes no C=C double bonds and leads to the LK.[1] After oxidation, the eicosanoids are further ...

"Protein-protein interaction affinity chromatography of leukotriene C4 synthase". Protein Expr. Purif. 6 (3): 352-6. doi:10.1006 ... This protein is remotely related to microsomal glutathione S-transferase. The MAPEG (Membrane-Associated Proteins in Eicosanoid ... 2000). "Membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG). A widespread protein superfamily". Am. J ... UMich Orientation of Proteins in Membranes families/superfamily-199 - Eicosanoid and Glutathione metabolism protein family ( ...

The protein biology approach to this research involved trying to map complex processes using limited samples, mainly of brain ... Genes encode proteins, so identifying the genes and specific genetic variations that patients tended to share more often than ... Although publishing steadily, Stefansson was frustrated by the pace of progress and often by not knowing whether the proteins ... 5, pp. 14-18, 5 October 1999. A 2009 report by genetics ethics watchdog GeneWatch, a vehement opponent of the IHD and the use ...

All three leukotrienes then bind at different affinities to two G-protein coupled receptors: CYSLTR1 and CYSLTR2, triggering ... Haeggström, Jesper Z.; Funk, Colin D. (2011-09-22). "Lipoxygenase and Leukotriene Pathways: Biochemistry, Biology, and Roles in ... stress and chemotherapy induce LTC4 biosynthesis by transcriptionally upregulating and activating the enzyme microsomal ... 122 (5): 518-23. PMID 8228569. Spanbroek, Rainer; Grabner, Rolf; Lotzer, Katharina; Hildner, Markus; Urbach, Anja; Ruhling, ...

2000). "Membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG). A widespread protein superfamily". Am. J ... The MAPEG (Membrane-Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, ... This gene encodes a protein that catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4 ... 161 (2 Pt 2): S20-4. doi:10.1164/ajrccm.161.supplement_1.ltta-5. PMID 10673221. Hillier LD, Lennon G, Becker M, et al. (1997 ...

... a specific kind of surgical flap 5-lipoxygenase activating protein (FLAP) The phenomenon of some variable or resource ...

The resulting 5-HPETE yields the unstable allylic epoxide substrate LTA4 which is quickly hydrolyzed by the LTA4H (leukotriene ... 5 (200): 200ra117. doi:10.1126/scitranslmed.3006674. ISSN 1946-6234. PMC 4016764. PMID 23986401. Abu, J. I.; Konje, J. C. ( ... In this pathway, arachidonic acid is converted into 5-hydroperoxyeicosatetraenoic acid (5-HPETE) as a result of a catalytic ... 5-LO) and FLAP (5-lipoxygenase-activating protein) in the presence of ATP and calcium ions. ...

In molecular biology the MAPEG (Membrane-Associated Proteins in Eicosanoid and Glutathione metabolism) family of proteins are a ... This article incorporates text from the public domain Pfam and InterPro: IPR001129 (Protein domains, Protein families). ... Protein Science. 8 (3): 689-92. doi:10.1110/ps.8.3.689. PMC 2144274. PMID 10091672. ... "Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis". Nature. 448 (7153): 609-12. ...

Unlike common variants, mutations causing rare diseases tend to be in the regions of genes that encode proteins, providing both ... activated a system to isolate anyone diagnosed with the virus and to trace and quarantine all of their contacts. Iceland's ... 5, no 1 February 2011, pp. 50-65 On deCODE in the context of the new genomics: Davies, Kevin, The $1,000 Genome: The Revolution ... 5 January 2017 C Brownstein, et al., "If I knew then what I know now: The need for infrastructure to enable precision medicine ...

... activate cells by releasing the Gq alpha subunit and pertussis toxin-sensitive Gi alpha subunit from Heterotrimeric G proteins ... and lipoxygenase-derived eicosanoids". Drug Metabolism and Disposition. 39 (2): 180-90. doi:10.1124/dmd.110.035121. PMC 3033693 ... but also bound and was activated by a wide range of peptides, proteins, and other agents. BLT2 may ultimately prove to have ... It activates cells through both its high affinity (Dissociation constant [Kd] of 0.5-1.5 nM) Leukotriene B4 receptor 1 (BLT1 ...

... cyclic adenosine monophosphate response element-binding protein phosphorylation, and p38 mitogen-activated protein kinase ... Delta12-lipoxygenase, 12Delta-lipoxygenase, and C-12 lipoxygenase. ALOX12, often termed plate platelet-type 12-lipoxygenase, is ... ALOX12 (EC 1.13.11.31), also known as arachidonate 12-lipoxygenase, 12-lipoxygenase, 12S-Lipoxygenase, 12-LOX, and 12S-LOX is a ... Tang K, Finley RL, Nie D, Honn KV (March 2000). "Identification of 12-lipoxygenase interaction with cellular proteins by yeast ...

... rho GTPase activating protein 21 ARID5B: encoding protein AT-rich interactive domain-containing protein 5B ARMH3: Armadillo ... encoding protein Transmembrane protein 26 TMEM72: encoding protein Transmembrane protein 72 TYSND1: encoding protein Trypsin ... WW domain binding protein 1-like ZNF37A: zinc finger protein 37A ZNF438: zinc finger protein 438 ZRANB1: Zinc finger ranbp2- ... plexin domain-containing protein 2 PRAP1: encoding protein Proline rich acidic protein 1 PROSER2: proline and serine rich 2 or ...

... p21-activated Kinase) Plectin p47PHOX Parvin (actopaxin) Prefoldin p53 PASK (Proline, Alanine rich Ste20 related Kinase) ... Actin-binding proteins (also known as ABPs) are proteins that bind to actin. This may mean ability to bind actin monomers, or ... This is a list of actin-binding proteins in alphabetical order. List: 0-9 A B C D E F G H I J K L M N O P Q R S T U V W x Y Z ... Profilin p185neu Ponticulin Protein kinase C Porin P.IB Prk1p (actin regulating kinase) Radixin (the R of ERM proteins) Rapsyn ...

Linker of activated T cells, Lymphocyte cytosolic protein 2, MAP2, MAP3K1 MAP4K1, MED28, MST1R, MUC1, Mitogen-activated protein ... "Induced direct binding of the adapter protein Nck to the GTPase-activating protein-associated protein p62 by epidermal growth ... the guanine nucleotide exchange protein Sos and a 75-kDa protein that is a substrate for T cell antigen receptor-activated ... "The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the ...

Furthermore, delivering the granule proteins into NETs may keep potentially injurious proteins like proteases from diffusing ... The result of the process then depends on which NETosis pathway is activated. Suicidal NETosis was first described in a 2007 ... The formation of NETs is regulated by the lipoxygenase pathway - during certain forms of activation (including contact with ... tubulin and various other cytoplasmatic proteins are not present in NETs. NETs disarm pathogens with antimicrobial proteins ...

... p38 mitogen-activated protein kinases, cytosolic phospholipase A2, PI3K/Akt, and protein kinase C beta and epsilon. The ... 12-Lipoxygenase (i.e. ALOX12) to metabolize 5(S)-HETE to 5(S),12(S)-diHETE. The activity of this product has not yet been fully ... HETE family stimulate cells primarily by binding and thereby activating a dedicated G protein-coupled receptor, the ... protein complex to dissociate into its Gαi and Gβγ components with Gβγ appearing to be the component responsible for activating ...

BLT2 receptors, similar to BLT1 receptors, are G protein coupled receptors that, when ligand-bound, activate G proteins that ... Finally, 12-lipoxygenase is overexpressed and the mass of 12-HETE is far higher in human prostate cancer than nearby normal ... "Induction of cyclooxygenase-2 by activated Ha-ras oncogene in Rat-1 fibroblasts and the role of mitogen-activated protein ... thereby activating calcium-activated intracellular signaling molecules; it also stimulates cells to activate Extracellular ...

... metabolites many of which act on cells by binding with and thereby activating specific and well-characterized receptor proteins ... Finally, there are relatively few metabolite-forming lipoxygenases and cyclooxygenases in the first and second pathways and ... Proteins and Proteomics. 1814 (1): 210-22. doi:10.1016/j.bbapap.2010.09.009. PMID 20869469. Moran, J. H.; Weise, R; Schnellmann ... "RTX proteins: A highly diverse family secreted by a common mechanism". FEMS Microbiology Reviews. 34 (6): 1076-112. doi:10.1111 ...

October 2004). "Human tribbles, a protein family controlling mitogen-activated protein kinase cascades". The Journal of ... Tang K, Finley RL, Nie D, Honn KV (March 2000). "Identification of 12-lipoxygenase interaction with cellular proteins by yeast ... The protein's primary structure contains a PEST region, indicative of proteins that are highly susceptible to degradation in ... Tribbles homolog 1 is a protein kinase that in humans is encoded by the TRIB1 gene. Orthologs of this protein pseudokinase ( ...

AA also activates syntaxin-3 (STX-3), a protein involved in the growth and repair of neurons. Arachidonic acid is also involved ... The enzymes 15-lipoxygenase-1 (ALOX15 and 15-lipoxygenase-2 (ALOX15B catalyzes the oxidation of arachidonic acid to 15- ... It also helps protect the brain from oxidative stress by activating peroxisome proliferator-activated receptor gamma. ... Receptors that activate this pathway include: A1 receptor D2 receptor α-2 adrenergic receptor 5-HT1 receptor PLC may also be ...

... rabbit 15-lipoxygenase and porcine leukocyte 12-lipoxygenase catalytic domain. The protein consists of a small N-terminal PLAT ... and thereby are key regulators in the formation of lipoxygenase-dependent metabolites. In addition, cells, when so activated, ... erythrocyte type 15-lipoxygenase (or 15-lipoxygenase, erythrocyte type), reticulocyte type 15-lipoxygenase (or 15-lipoxygenase ... LOX-DB - LipOXygenases DataBase Lipoxygenases iron-binding region in PROSITE PDB: 1YGE​ - structure of lipoxygenase-1 from ...

The lipoxygenase-5 inhibitor minocycline has been seen to be marginally effective in halting schizophrenia progression. One of ... Okada, F.; Crow, T. J.; Roberts, G. W. (1990). "G-proteins (Gi, Go) in the basal ganglia of control and schizophrenic brain". ... Similarly, toxoplasmosis infection in the CNS (positively correlated to schizophrenia) activates inflammatory cascades, also ... Guo, W.; Shi, L.; Filizola, M.; Weinstein, H.; Javitch, J. A. (2005). "Crosstalk in G protein-coupled receptors: Changes at the ...

Tang K, Finley RL, Nie D, Honn KV (March 2000). "Identification of 12-lipoxygenase interaction with cellular proteins by yeast ... "Epidermal lipoxygenase products of the hepoxilin pathway selectively activate the nuclear receptor PPARalpha". Lipids. 42 (6): ... Arachidonate 12-lipoxygenase, 12R type, also known as ALOX12B, 12R-LOX, and arachidonate lipoxygenase 3, is a lipoxygenase-type ... "Entrez Gene: ALOX12B arachidonate 12-lipoxygenase, 12R type". Boeglin WE, Kim RB, Brash AR (June 1998). "A 12R-lipoxygenase in ...