... is in the thiopurine and antimetabolite family of medications. Mercaptopurine was approved for medical use in ... "Label: Mercaptopurine - mercaptopurine tablet". Archived from the original on 6 October 2015. Retrieved 11 March 2015. "Purixan ... leading to the US FDA rating both AZA and mercaptopurine as category D drugs. However, Davis et al. 1999 found mercaptopurine, ... Animal tumors that are resistant to mercaptopurine often have lost the ability to convert mercaptopurine to TIMP. However, it ...

Elion's research contributed to the development of: Mercaptopurine (Purinethol), the first treatment for leukemia, also used in ... she developed the anti-cancer drugs tioguanine and mercaptopurine.: 66 She pursued graduate studies at night school at New York ... 77 (6): 1676. doi:10.1021/ja01611a082. In 1988 Elion received the Nobel Prize in Physiology or Medicine, together with ... Elion, Gertrude B.; Hitchings, George H. (1955). "The Synthesis of 6-Thioguanine". Journal of the American Chemical Society. ...

RAF1 Noonan syndrome 6; 613224; NRAS Noonan-like syndrome with loose anagen hair; 607721; SHOC2 Norrie disease; 310600; NDP ... 6; 612201; NPPA Atrial fibrillation, familial, 7; 612240; KCNA5 Atrial septal defect 4; 611363; TBX20 Atrial septal defect 5; ... CHD7 Kallmann syndrome 6; 612702; FGF8 Kanzaki disease; 609242; NAGA Karak syndrome; 610217; PLA2G6 Kenny-Caffey syndrome-1; ... 6; 611092; GRIK2 Mental retardation, FRA12A type; 136630; DIP2B Mental retardation, joint hypermobility and skin laxity, with ...

A 2003 population-based study in Denmark showed that the use of azathioprine and related mercaptopurine resulted in a seven- ... Ansari A, Patel N, Sanderson J, O'Donohue J, Duley JA, Florin TH (March 2010). "Low-dose azathioprine or mercaptopurine in ... Nørgård B, Pedersen L, Fonager K, Rasmussen SN, Sørensen HT (March 2003). "Azathioprine, mercaptopurine and birth outcome: a ... mercaptopurine on the rat litter in utero". Journal of Reproduction and Fertility. 4 (3): 297-302. doi:10.1530/jrf.0.0040297. ...

Mercaptopurine Mercaptopurine is a medication for cancer and autoimmune diseases including acute lymphocytic leukemia (ALL), ... 129: 714-6. Freier, Phyllis; Lofgren, E. J.; Ney, E. P.; Oppenheimer, F.; Bradt, H. L.; Peters, B. (1948-07-15). "Evidence for ... She has obtained 6 patents. The product makes use of artificial intelligence and Internet of Things to understand user ... "Chemical & Engineering News: Top Pharmaceuticals: 6-Mercaptopurine". pubs.acs.org. Retrieved 2018-08-07. Vasudevan, D.M.; ...

13 (6): 495-500. doi:10.1007/BF02874220. PMID 5753016. S2CID 6757321. Horáková, K; Drobnica, L; Nemec, P; Antos, A; Kristián, P ... 16 (6): 591-6. PMID 5369024. Horáková, K; Drobnica, L; Nemec, P; Uher, M (1970). "Cyttoxic and cancerostatic activity of ... 27 (6): 408-12. doi:10.7164/antibiotics.27.408. PMID 4851620. Horáková, K; Kalafut, F; Navarová, J; Paterson, AR (1974). " ... 30 (6): 517-25. PMID 7032713. Horáková, K.; Jantová, S.; Devínsky, F. (1985). "Examination of the relation between the ...

Among these, albendazole, amoxicillin, amoxicillin-clavulanate, allopurinol, mercaptopurine, mupirocin, pyrimethamine, ... such as mercaptopurine. In 1959, the Wellcome Foundation bought Cooper, McDougall & Robertson Inc to become more active in ... mercaptopurine, pyrimethamine and zidovudine. In 2012, under prosecution by the United States Department of Justice (DoJ) based ... mercaptopurine and thioguanine for the treatment of leukemia, allopurinol for gout, pyrimethamine for malaria, and the ...

6 (1): 75-81. doi:10.1517/17425250903393745. ISSN 1742-5255. PMID 19968576. S2CID 41433204. Ghanem H, Kantarjian H, Ohanian M, ... "Azathioprine and 6-mercaptopurine for maintenance of remission in ulcerative colitis". The Cochrane Database of Systematic ...

6-mercaptopurine as a long-term therapy may prevent pulmonary haemorrhage. A 2007 scientific letter reports preliminary success ... Luo XQ, Ke ZY, Huang LB, Guan XQ, Zhang XL, Zhu J, Zhang YC (Nov 2008). "Maintenance therapy with dose-adjusted 6- ... mercaptopurine in idiopathic pulmonary hemosiderosis". Pediatric Pulmonology. 43 (11): 1067-71. doi:10.1002/ppul.20894. PMID ... 133 (6): 609-11. doi:10.1001/archpedi.1979.02130060049010. PMID 375718. Gilman PA, Zinkham WH (1969). "Severe idiopathic ...

Azathioprine and 6-MP may be useful for the following indications: Maintenance therapy with azathioprine or 6-mercaptopurine ... 347 (6): 417-29. doi:10.1056/NEJMra020831. PMID 12167685. Dejaco, C.; Harrer, M.; Waldhoer, T.; Miehsler, W.; Vogelsang, H.; ... 18 (6): 419, author reply 419. PMID 15230268. ""Cannabis-based drugs could offer new hope for inflammatory bowel disease ... There may also be an increased risk of lymphoma that is associated with azathioprine or 6-mercaptopurine treatment. ...

23 (R1): R40-6. doi:10.1093/hmg/ddu125. PMID 24651067. Rubin AJ, Parker KR, Satpathy AT, Qi Y, Wu B, Ong AJ, et al. (January ... The allele UGT1A1*6 is characterized by a SNP in exon 1. Irinotecan is a prodrug used in the treatment of many solid tumours, ... 64 (12): 4353-6. doi:10.1158/0008-5472.CAN-04-0340. PMID 15205351. Wen Y, Gorsic LK, Wheeler HE, Ziliak DM, Huang RS, Dolan ME ... A UGT1A1*28 allele means the presence of 7 TA repeats in the promoter sequence of the gene, instead of the normal 6 repeats. ...

Ansari A, Patel N, Sanderson J, O'Donohue J, Duley JA, Florin TH (March 2010). "Low-dose azathioprine or mercaptopurine in ... However, no improvement in leukemia response was noted with mercaptopurine-allopurinol co-therapy, so that work turned to other ... Because allopurinol inhibits the breakdown (catabolism) of the thiopurine drug mercaptopurine, and it was later tested by Wayne ... 156 (1): 4-6. doi:10.1111/j.1476-5381.2008.00065.x. PMC 2697767. PMID 19133987. Dalbeth N, Stamp L (2007). "Allopurinol dosing ...

When the patents were filed, the metabolites of these drugs were known, most importantly, 6-thioguanine, but the "right" level ... 2000). "Pharmacogenomics and metabolite measurement for 6-mercaptopurine therapy in inflammatory bowel disease". ... wherein the level of 6-thioguanine less than about 230 pmol per 8x108 red blood cells indicates a need to increase the amount ... administering a drug providing 6-thioguanine to a subject having said immune-mediated gastrointestinal disorder; and (b) ...

The molecular formula C5H4N4S (molar mass : 152.18 g/mol) may refer to : Mercaptopurine, an immunosuppressive drug Tisopurine, ... a treatment of gout "Mercaptopurine". The American Society of Health-System Pharmacists. Archived from the original on 20 ... 46 (6): 493. doi:10.1136/ard.46.6.493-a. PMC 1002174. PMID 3632073. This set index page lists chemical structure articles ... doi:10.1007/s00228-008-0478-6. PMID 18506437. S2CID 27475772. British national formulary : BNF 69 (69 ed.). British Medical ...

46 (6): 493. doi:10.1136/ard.46.6.493-a. PMC 1002174. PMID 3632073. v t e (Articles with short description, Short description ... oxipurinol and 6-mercaptopurine". British Journal of Clinical Pharmacology. 1 (2): 119-27. doi:10.1111/j.1365-2125.1974.tb00220 ...

1997). "Molecular diagnosis of thiopurine S-methyltransferase deficiency: genetic basis for azathioprine and mercaptopurine ... Weinshilboum RM, Sladek SL (1980). "Mercaptopurine pharmacogenetics: Monogenic inheritance of erythrocyte thiopurine ... 14 (7): 395-6. doi:10.1097/01.fpc.0000114753.08559.e9. PMID 15226671. Coulthard SA, Matheson EC, Hall AG, Hogarth LA (2005). " ... 6 (4): 279-90. doi:10.1097/00008571-199608000-00001. PMID 8873214. Krynetski E, Evans WE (2003). "Drug methylation in cancer ...

Mercaptopurine, or 6-MP is an analog of guanine, and inhibits cellular replication through multiple mechanisms. 6-MP halts ... "Mercaptopurine: Mechanism of Action". IBM Micromedex. "Prednisone: Mechanism of Action". IBM Micromedex. "Prednisone (Oral ... The VAMP regimen developed by Freireich and Frei was a combination of vincristine, amethopterin, mercaptopurine, and prednisone ... VAMP includes four drugs, vincristine, amethopterin, mercaptopurine, and prednisone, operating under independent pathways, ...

28 (5-6): 283-289. doi:10.1080/019131290882150. PMID 15764577. S2CID 28447192. Gellhorn, Alfred; Peterson, Edith R.; Kells, ... "The effects of 6-mercaptopurine, 8-azaguanine, and 1-4,dimethanesulfonyloxybutane on an experimental brain tumor". Annals of ...

With mercaptopurine present, cells are not able to make DNA, and cell division is inhibited. In administering mercaptopurine it ... Mercaptopurine is a cytostatic drug that is an antimetabolite. The mercaptopurine molecule mimics purine, which is necessary ... Mercaptopurine inhibits the production of white blood cells generally. Because this makes the body more susceptible to ... Frequent blood cell counts are also recommended during administration of mercaptopurine. The drug may be toxic to bone marrow, ...

30 (6): 296-304. doi:10.1159/000028814. ISSN 1016-2291. PMID 10494055. Sharp, Lesley A. (2013). The Transplant Imaginary: ... After reading results of experimental studies by Roy Calne, Küss had already administered 6-mercaptopurine six years earlier. ...

6-Mercaptopurine (6-MP) 6-Thioguanine (6-TG) Azathioprine (AZA) Sahasranaman S, Howard D, Roy S (August 2008). "Clinical ... doi:10.1007/s00228-008-0478-6. PMID 18506437. Supreme Court Decision. Mayo Collaborative Services v. Prometheus Laboratories, ...

Gertrude Elion (Lemelson-MIT Lifetime Achievement Award) for the following inventions: 6-mercaptopurine (Purinethol), the first ...

4 (8): 1010-6, quiz 934. doi:10.1016/j.cgh.2006.05.017. PMID 16843735. Okazaki, K (November 2003). "Autoimmune pancreatitis is ... Immunomodulators such as azathioprine, and 6-mercaptopurine have been shown to extend remission of autoimmune pancreatitis ... irregular mass was observed in 6 (46%) patients. Whereas EUS-FNA is sensitive and specific for the diagnosis of pancreatic ...

April 2015). "Inherited NUDT15 variant is a genetic determinant of mercaptopurine intolerance in children with acute ... April 2015). "Inherited NUDT15 variant is a genetic determinant of mercaptopurine intolerance in children with acute ... November 2016). "NUDT15 gene polymorphism related to mercaptopurine intolerance in Taiwan Chinese children with acute ... mercaptopurine) in acute lymphoblastic leukemia as well as inflammatory bowel diseases to avoid thiopurine-induced leukopenia. ...

31 (6): 234-241. doi:10.1542/pir.31-6-234. PMID 20516235. Cordo' V, van der Zwet JC, Canté-Barrett K, Pieters R, Meijerink JP ( ... p. 5-6. "A Snapshot of Leukemia". NCI. Archived from the original on 4 July 2014. Retrieved 18 June 2014. "Search of: leukemia ... Thomas, Xavier (6 August 2013). "First contributors in the history of leukemia". World Journal of Hematology. 2 (3): 62-70. doi ... 23 (6): 1175-1182. doi:10.1016/j.drudis.2018.02.012. hdl:1765/105338. PMID 29501911. "How we're beating leukaemia". Leukaemia ...

On the other hand, some cases of IBD that are resistant to mercaptopurine (or its pro-drug azathioprine) may be responsive to ... Cancers that do not respond to treatment with mercaptopurine do not respond to thioguanine. ... The plasma half-life of thioguanine is short, due to the rapid uptake into liver and blood cells and conversion to 6-TGN. The ... 6-Thioguanine is a thio analogue of the naturally occurring purine base guanine. 6-thioguanine utilises the enzyme hypoxanthine ...

The addition of 6-thioguanine gave rise to the DAT regimen, and the addition of 6-mercaptopurine gave rise to the DAM regimen. ...

The term sulfhydryl- or mercapto- is used as a prefix, e.g. mercaptopurine. Many thiols have strong odors resembling that of ... 6, p. 824. Ernest L. Eliel, Joseph E. Lynch, Fumitaka Kume, and Stephen V. Frye (1993). "Chiral 1,3-oxathiane from (+)-Pulegone ... Thiophenol has a pKa of 6, versus 10 for phenol. A highly acidic thiol is pentafluorothiophenol (C6F5SH) with a pKa of 2.68. ... 6, p. 979. Melvin S. Newman and Frederick W. Hetzel (1990). "Thiophenols from Phenols: 2-Naphthalenethiol". Organic Syntheses ...

97 (7): 3491-6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800. Wijnholds J, Mol CA, van ... doi:10.1016/S0378-1119(99)00529-6. PMID 10721709. Oguri T, Isobe T, Suzuki T, Nishio K, Fujiwara Y, Katoh O, Yamakido M (Apr ... 22 (6): 707-16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390. Jedlitschky G, Tirschmann K, Lubenow LE, Nieuwenhuis HK, ... Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercaptopurine and thioguanine, and the ...

149 (5): 541-6. PMC 1026530. PMID 3250100. Moum B, Vatn MH, Ekbom A, Aadland E, Fausa O, Lygren I, Stray N, Sauar J, Schulz T ( ... 54 (6): 577-82. doi:10.1046/j.1365-2125.2002.01699.x. PMC 1874503. PMID 12492603. Shang A, Huwiler-Müntener K, Nartey L, Jüni P ... 29 (7): 990-6. doi:10.1136/gut.29.7.990. PMC 1433769. PMID 3396969. Burisch J, Jess T, Martinato M, Lakatos PL (May 2013). "The ... 60 (6): 985. doi:10.1016/S0016-5107(04)02200-X. PMID 15605018. Antonelli E, Bassotti G, Tramontana M, Hansel K, Stingeni L, ...