The A-kinase anchoring proteins or A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have ... Marin, Wenwen (January 2020). "A-kinase anchoring protein 1 (AKAP1) and its role in some cardiovascular diseases". Journal of ... Articles with short description, Short description matches Wikidata, A-kinase-anchoring proteins). ... AKAPs act as scaffold proteins wherein they bind PKA and other signaling proteins and physically tether these multi-protein ...

"Targeting of Protein Kinase A by Muscle A Kinase-anchoring Protein (mAKAP) Regulates Phosphorylation and Function of the ... It should not be confused with 5'-AMP-activated protein kinase (AMP-activated protein kinase). Protein kinase A, more precisely ... Protein kinase Signal transduction G protein-coupled receptor Serine/threonine-specific protein kinase Myosin light-chain ... out of 540 different protein kinase genes that make up the human kinome, only one other protein kinase, casein kinase 2, is ...

This gene encodes a member of the A-kinase anchoring protein (AKAP) family, a group of functionally related proteins that bind ... "A novel lipid-anchored A-kinase Anchoring Protein facilitates cAMP-responsive membrane events". The EMBO Journal. 17 (8): 2261- ... "Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein ... A-kinase anchor protein 7 isoform gamma is an enzyme that in humans is encoded by the AKAP7 gene. ...

2003). "Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: a disease susceptibility ... "Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein ... "Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein ... A-kinase anchor protein 2 is an enzyme that in humans is encoded by the AKAP2 gene. AKAP2 has been shown to interact with ...

A-kinase anchor protein 8-like is a protein that in humans is encoded by the AKAP8L gene. AKAP8L has been shown to interact ... cloning and characterization of a novel nuclear protein, HA95, homologous to A-kinase anchoring protein 95". Biology of the ... "Entrez Gene: AKAP8L A kinase (PRKA) anchor protein 8-like". Yang JP, Tang H, Reddy TR, Wong-Staal F (Aug 2001). "Mapping the ... neighbor of A-kinase anchoring protein 95 (AKAP95) on chromosome 19p13.11-p13.12 region". Journal of Human Genetics. 45 (1): ...

A-kinase anchor protein 6 is an enzyme that in humans is encoded by the AKAP6 gene. The A-kinase anchor proteins (AKAPs) are a ... "Cloning and characterization of A-kinase anchor protein 100 (AKAP100). A protein that targets A-kinase to the sarcoplasmic ... "Entrez Gene: AKAP6 A kinase (PRKA) anchor protein 6". Marx, S O; Reiken S; Hisamatsu Y; Jayaraman T; Burkhoff D; Rosemblit N; ... Kapiloff MS, Schillace RV, Westphal AM, Scott JD (1999). "mAKAP: an A-kinase anchoring protein targeted to the nuclear membrane ...

Howlett CJ, Robbins SM (March 2002). "Membrane-anchored Cbl suppresses Hck protein-tyrosine kinase mediated cellular ... "The Cbl proteins are binding partners for the Cool/Pix family of p21-activated kinase-binding proteins". FEBS Lett. 550 (1-3): ... is a mammalian gene encoding the protein CBL which is an E3 ubiquitin-protein ligase involved in cell signalling and protein ... N-terminal tyrosine kinase binding domain (TKB domain): determines the protein which it can bind to RING finger domain motif: ...

Another protein essential for the SI response is MLPK, a serine-threonine kinase, which is anchored to the plasma membrane from ... Murase K, Shiba H, Iwano M, Che FS, Watanabe M, Isogai A, Takayama S (March 2004). "A membrane-anchored protein kinase involved ... The female determinant of the SI response in Brassica, is a transmembrane protein termed SRK, which has an intracellular kinase ... The interaction between the SRK and SCR/SP11 proteins results in autophosphorylation of the intracellular kinase domain of SRK ...

Chen L, Marquardt ML, Tester DJ, Sampson KJ, Ackerman MJ, Kass RS (2007). "Mutation of an A-kinase-anchoring protein causes ... Golgi reassembly-stacking proteins are an evolutionarily conserved family of proteins in the Golgi matrix. GRASP65 and GRASP55 ... encoding a transmembrane protein with a presumed role in vesicle-mediated sorting and intracellular protein transport". Am. J. ... The first individual protein component of the matrix was identified in 1995 as Golgin A2 (then called GM130). Since then, many ...

A-kinase anchor protein 5 is a protein that in humans is encoded by the AKAP5 gene. The A-kinase anchor proteins (AKAPs) are a ... 1995). "Association of protein kinase A and protein phosphatase 2B with a common anchoring protein". Science. 267 (5194): 108- ... "A-kinase anchoring protein 79/150 facilitates the phosphorylation of GABA(A) receptors by cAMP-dependent protein kinase via ... "Localization of the cAMP-dependent protein kinase to the postsynaptic densities by A-kinase anchoring proteins. ...

A-kinase anchor protein 8 is an enzyme that, in humans, is encoded by the AKAP8 gene. The A-kinase anchor proteins (AKAPs) are ... Collas P, Le Guellec K, Taskén K (Dec 1999). "The A-kinase-anchoring protein AKAP95 is a multivalent protein with a key role in ... 2003). "Protein kinase A-anchoring protein AKAP95 interacts with MCM2, a regulator of DNA replication". J. Biol. Chem. 278 (29 ... Collas P, Le Guellec K, Taskén K (2000). "The A-kinase-anchoring protein AKAP95 is a multivalent protein with a key role in ...

A-kinase anchor protein 12, aka AKAP250, is an enzyme that in humans is encoded by the AKAP12 gene. The A-kinase anchor ... Fan G, Shumay E, Wang H, Malbon CC (2001). "The scaffold protein gravin (cAMP-dependent protein kinase-anchoring protein 250) ... "The scaffold protein gravin (cAMP-dependent protein kinase-anchoring protein 250) binds the beta 2-adrenergic receptor via the ... Piontek J, Brandt R (2003). "Differential and regulated binding of cAMP-dependent protein kinase and protein kinase C ...

A kinase anchor protein 10, mitochondrial is an enzyme that in humans is encoded by the AKAP10 gene. The A-kinase anchor ... Huang LJ, Durick K, Weiner JA, Chun J, Taylor SS (November 1997). "D-AKAP2, a novel protein kinase A anchoring protein with a ... a protein kinase A anchoring protein". Proc. Natl. Acad. Sci. U.S.A. 98 (6): 3220-5. Bibcode:2001PNAS...98.3220W. doi:10.1073/ ... "Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: a disease susceptibility ...

A-kinase anchor protein 11 is an enzyme that in humans is encoded by the AKAP11 gene. The A-kinase anchor proteins (AKAPs) are ... "A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent ... "A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent ... Schillace RV, Scott JD (March 1999). "Association of the type 1 protein phosphatase PP1 with the A-kinase anchoring protein ...

A-kinase anchor protein 4 is a scaffold protein that in humans is encoded by the AKAP4 gene. It involves in the intracellular ... The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to ... Brown PR, Miki K, Harper DB, Eddy EM (June 2003). "A-kinase anchoring protein 4 binding proteins in the fibrous sheath of the ... Brown PR, Miki K, Harper DB, Eddy EM (June 2003). "A-kinase anchoring protein 4 binding proteins in the fibrous sheath of the ...

Mochly-Rosen D (Apr 1995). "Localization of protein kinases by anchoring proteins: a theme in signal transduction". Science. ... Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the ... "Characterization of protein kinase C isotype expression in adult rat heart. Protein kinase C-epsilon is a major isotype present ... PRKCE protein kinase C, epsilon". Newton PM, Messing RO (Apr 2010). "The substrates and binding partners of protein kinase ...

Lea IA, Widgren EE, O'Rand MG (2004). "Association of sperm protein 17 with A-kinase anchoring protein 3 in flagella". Reprod. ... Frayne J, Hall L (2003). "A re-evaluation of sperm protein 17 (Sp17) indicates a regulatory role in an A-kinase anchoring ... Sperm surface protein Sp17 is a protein that in humans is encoded by the SPA17 gene. This gene encodes a protein present at the ... Studies in rabbits suggest that in sperm the protein is involved in fertilization by binding to the zona pellucida of the ...

"The A-kinase anchor protein AKAP121 is a negative regulator of cardiomyocyte hypertrophy". Journal of Molecular and Cellular ... "Induction of cardiomyocyte hypertrophy by specific knockdown of an a-kinase anchor protein". Journal of Molecular and Cellular ...

"Association of protein kinase A and protein phosphatase 2B with a common anchoring protein". Science. 267 (5194): 108-11. ... Calcineurin (CaN) is a calcium and calmodulin dependent serine/threonine protein phosphatase (also known as protein phosphatase ... Giri PR, Higuchi S, Kincaid RL (1991). "Chromosomal mapping of the human genes for the calmodulin-dependent protein phosphatase ... Frey N, Richardson JA, Olson EN (2000). "Calsarcins, a novel family of sarcomeric calcineurin-binding proteins". Proc. Natl. ...

... evolutionarily conserved human gene family encoding proteins with presumptive protein kinase A anchoring function". Genomics. ... LRBA contains key features of both beige/CHS1 and A kinase anchor proteins (AKAPs; see MIM 602449).[supplied by OMIM] ... of a novel lipopolysaccharide-inducible gene with key features of both A kinase anchor proteins and chs1/beige proteins". J ... Lipopolysaccharide-responsive and beige-like anchor protein is a protein that in humans is encoded by the LRBA gene. Patients ...

The protein becomes activated when binding to receptors capable of protein kinase activity for cellular signaling. TGF-α is a ... As a membrane anchored-growth factor, TGF-α can be cleaved from an integral membrane glycoprotein via a protease. Soluble forms ... When TGF-α binds to EGFR it dimerizes triggering phosphorylation of a protein-tyrosine kinase. The activity of protein-tyrosine ... This protein may act as either a transmembrane-bound ligand or a soluble ligand. This gene has been associated with many types ...

Dart C, Leyland ML (2001). "Targeting of an A kinase-anchoring protein, AKAP79, to an inwardly rectifying potassium channel, ... The resulting protein eNpHR3.0 is used in optogenetic research to inhibit neurons with light. Expression of Kir2.1 gene in ... GeneReviews/NCBI/NIH/UW entry on Andersen-Tawil syndrome OMIM entries on Anderson-Tawil syndrome KCNJ2+protein,+human at the U. ... Kurschner C, Yuzaki M (1999). "Neuronal interleukin-16 (NIL-16): a dual function PDZ domain protein". J. Neurosci. 19 (18): ...

Ulfig N, Chan WY (2003). "Expression of a kinase anchoring protein 79 and synaptophysin in the developing human red nucleus". ... The encoded protein has 313 amino acids with a predicted molecular weight of 33.845 kDa. The protein is a synaptic vesicle ... Synaptophysin, also known as the major synaptic vesicle protein p38, is a protein that in humans is encoded by the SYP gene. ... The exact function of the protein is unknown: it interacts with the essential synaptic vesicle protein synaptobrevin, but when ...

Diviani D, Langeberg LK, Doxsey SJ, Scott JD (Apr 2000). "Pericentrin anchors protein kinase A at the centrosome through a ... protein kinase A, protein kinase C, DISC1, γ-tubulin complex proteins, and PCM1. GRCh38: Ensembl release 89: ENSG00000160299 - ... This protein localizes to the centrosome and recruits proteins to the pericentriolar matrix (PCM) to ensure proper centrosome ... which is a centrosome scaffold that anchors microtubule nucleating complexes and other centrosomal proteins. In one model, PCNT ...

"Glycosylphosphatidylinositol-anchored proteins as chaperones and co-receptors for FERONIA receptor kinase signaling in ... "FER - Receptor-like protein kinase FERONIA precursor - Arabidopsis thaliana (Mouse-ear cress) - FER gene & protein". www. ... Feronia, also known as FER or protein Sirene, is a recognition receptor kinase found in plants. FER plays a significant part in ... FER is one of the known 17 proteins which play a part in Arabidopsis Catharanthus roseus RLK1-like kinases (CrRLK1Ls). ...

A-kinase-anchoring proteins (AKAPs) bind a surface formed between both R subunits and target the kinase to different locations ... Protein kinase A catalytic subunit (PKA Cα) is a member of the AGC kinase family (protein kinases A, G, and C), and contributes ... Snyder EM, Colledge M, Crozier RA, Chen WS, Scott JD, Bear MF (Apr 2005). "Role for A kinase-anchoring proteins (AKAPS) in ... This led to the hypothesis that the subcellular localization of anchored PKA controls what proteins are regulated by the kinase ...

Mochly-Rosen D (April 1995). "Localization of protein kinases by anchoring proteins: a theme in signal transduction". Science. ... "Protein kinase C-associated kinase (PKK), a novel membrane-associated, ankyrin repeat-containing protein kinase". The Journal ... Protein kinase C beta type is an enzyme that in humans is encoded by the PRKCB gene. Protein kinase C (PKC) is a family of ... December 1996). "Protein-protein interaction of zinc finger LIM domains with protein kinase C". The Journal of Biological ...

The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway ... Li S, Couet J, Lisanti MP (November 1996). "Src tyrosine kinases, Galpha subunits, and H-Ras share a common membrane-anchored ... Caveolin 1 has been shown to interact with heterotrimeric G proteins, Src tyrosine kinases (Src, Lyn) and H-Ras,cholesterol,TGF ... Caveolin-1 is a protein that in humans is encoded by the CAV1 gene. The scaffolding protein encoded by this gene is the main ...

"Centrosomal proteins CG-NAP and kendrin provide microtubule nucleation sites by anchoring gamma-tubulin ring complex". Mol. ... "Entrez Gene: CALM1 calmodulin 1 (phosphorylase kinase, delta)". Takahashi M, Yamagiwa A, Nishimura T, Mukai H, Ono Y (Sep 2002 ... Calmodulin 1 is a protein that in humans is encoded by the CALM1 gene. Calmodulin 1 is the archetype of the family of calcium- ... Gusev NB (2002). "Some properties of caldesmon and calponin and the participation of these proteins in regulation of smooth ...

Diviani D, Soderling J, Scott JD (November 2001). "AKAP-Lbc anchors protein kinase A and nucleates Galpha 12-selective Rho- ... Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG". The Journal of ... Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG". The Journal of ... Ras homolog gene family, member B, also known as RHOB, is a protein which in humans is encoded by the RHOB gene. RHOB is a ...