TumorsHepatocellular carcinomaMetastaticPrognosis2018MalignantSquamous Cell CarcTumorigenesisClinicalMutationsIncidenceAdenomaTherapeutic TargetsEpidemiologyHttpsAdrenal cortexPathologicalSurvivalTumourDiagnosisPrognosticPatientTP53GermlinePrimaryCharacteristicsChildhoodTreatmentAnalysisJournalStudyOutcomeHighSystem
Tumors15
- Only 2% of tumors that are less than 4 cm are adrenocortical carcinomas. (medscape.com)
- Adrenocortical tumors encompass a spectrum of diseases with often seamless transition from benign (adenoma) to malignant (carcinoma) behavior. (oncolink.org)
- The incidence of adrenocortical tumors in children is extremely low (only 0.2% of pediatric cancers). (oncolink.org)
- Adrenocortical tumors appear to follow a bimodal distribution, with peaks during the first and fourth decades. (oncolink.org)
- Childhood adrenocortical tumors typically present during the first 5 years of life (median age, 3-4 years), although there is a second, smaller peak during adolescence. (oncolink.org)
- Internationally, however, the incidence of adrenocortical tumors appears to vary substantially. (oncolink.org)
- Clinical and outcome characteristics of children with adrenocortical tumors: a report from the International Pediatric Adrenocortical Tumor Registry. (oncolink.org)
- Mortality rate of adrenocortical tumors in children under 15 years of age in Curitiba, Brazil. (oncolink.org)
- Biology, clinical characteristics, and management of adrenocortical tumors in children. (oncolink.org)
- Rodriguez-Galindo C: Adrenocortical tumors in children. (oncolink.org)
- Germline TP53 mutations are almost always the predisposing factor for adrenocortical tumors. (oncolink.org)
- In the non-Brazilian cases, relatives of children with adrenocortical tumors often, although not invariably, have a high incidence of nonadrenal cancers (Li-Fraumeni syndrome). (oncolink.org)
- Adrenocortical carcinoma (ACC) can be classified into functioning and nonfunctioning tumors by clinical and biochemical assessment. (cancer.gov)
- MATERIALS AND METHODS: Twist1, fibronectin, vimentin and E-cadherin gene expression in 18 adrenal adenomas, 18 ACC, and 24 childhood onset adrenocortical tumors were assessed in formalin-fixed paraffin-embedded tissues. (bvsalud.org)
- Adrenocortical carcinomas (ACC) are very rare tumors related to TP53 mutations mostly in childhood onset cases. (bvsalud.org)
Hepatocellular carcinoma6
- Phase II clinical trials were initiated for multiple myeloma, ovarian cancer, hepatocellular carcinoma, and NSCLC, but subsatisfactory results caused research for these indications to be discontinued. (wikipedia.org)
- Dysfunctions of long non-coding RNA (lncRNAs) have been associated with the initiation and progression of hepatocellular carcinoma (HCC), but the clinicopathologic significance and potential role of lncRNA PTTG3P (pituitary tumor-transforming 3, pseudogene) in HCC remains largely unknown. (biomedcentral.com)
- Hepatocellular carcinoma (HCC) ranks as the fifth most common cancer in men and the seventh in women with annual incidence rates of ~ 750,000 worldwide [ 1 , 2 ]. (biomedcentral.com)
- Our previous findings suggest the extensive mechanism of quercetin (QUE) mediated regression of cell survival, cell proliferation, oxidative stress, inflammation, and angiogenesis via modulating PI3K and PKC signaling in lym- phoma as well as hepatocellular carcinoma. (pi3k-inhibitors.com)
- 2015). Our previous finding entails the QUE-mediated regression of cell survival, cell proliferation, oxidative stress, inflammation, and angiogenesis in lympho- ma as well as hepatocellular carcinoma via modulating PI3K and PKC signaling (Maurya and Vinayak 2015a, b, c, 2016a, 2017a). (pi3k-inhibitors.com)
- The prognostic value of AS events has been demonstrated in several cancer types, such as breast cancer ( 7 - 9 ), hepatocellular carcinoma ( 10 , 11 ), gastric cancer ( 12 , 13 ), and others ( 14 - 23 ). (frontiersin.org)
Metastatic4
- A Phase II Study to Evaluate the Effects of Cabozantinib in Patients with Unresectable/Metastatic Adrenocortical Carcinoma. (mdanderson.org)
- The goal of this clinical research study is to learn if cabozantinib can help to control unresectable (cannot be removed with surgery) or metastatic (has spread) adrenocortical carcinomas. (mdanderson.org)
- Khan MI, Waguespack SG, Habra MA, Broaddus R, Jimenez C. Acute-onset ectopic adrenocorticotropic hormone syndrome secondary to metastatic endometrioid carcinoma of the ovaries as a fatal complication. (foxchase.org)
- Metastatic and recurrent adrenocortical cancer is not defined by its genomic landscape. (cdc.gov)
Prognosis3
- Adrenocortical carcinoma (ACC) (also known as adrenal cortical carcinoma) is a rare malignancy with a poor prognosis, affecting 1-2 people per million per year year. (medscape.com)
- Xu F , Guan Y , Ma Y , Xue L , Zhang P , Yang X , Chong T , . Bioinformatic analyses and experimental validation of the role of m6A RNA methylation regulators in progression and prognosis of adrenocortical carcinoma. (aging-us.com)
- Introduction: Adrenocortical Carcinoma (ACC) is a rare and aggressive tumor with poor prognosis. (endocrine-abstracts.org)
20181
- Esophageal carcinoma (EC) is the seventh most frequent cancer and the sixth leading cause of cancer mortality in the world according to the 2018 Global Cancer Statistics ( 1 ). (frontiersin.org)
Malignant3
- Berstein L, Gurney JG: Carcinomas and other malignant epithelial neoplasms. (oncolink.org)
- Adrenocortical carcinoma (ACC) is a rare malignant tumor with an incidence rate of approximately 0.7/million to 2.0/million in the population [ 1 ]. (aging-us.com)
- BACKGROUND: Oral leukoplakia is the most common potentially malignant disorder in the oral cavity and can precede carcinoma. (bvsalud.org)
Squamous Cell Carc1
Tumorigenesis1
- BACKGROUND/AIM: Although the knowledge regarding adrenocortical carcinomas (ACC) tumorigenesis has significantly improved during the last decade, it still remains to be completely determined. (bvsalud.org)
Clinical6
- A phase III clinical trial found that linsitinib did not increase survival in patients with adrenocortical carcinoma. (wikipedia.org)
- As of 2017, no clinical trials were in progress. (wikipedia.org)
- Adrenocortical Carcinoma: Basic Science and Clinical Concepts. (cancer.gov)
- Allolio B, Fassnacht M: Clinical review: Adrenocortical carcinoma: clinical update. (cancer.gov)
- The goal of this clinical research study is to learn if mitotane alone or in combination with cisplatin and etoposide can help to control adrenocortical carcinoma (ACC) in patients who are at a high risk of having the disease return after surgery. (mdanderson.org)
- Some elegant clinical observations of dysregulated cortisol-secretion in cases of ACTH-independent macronodular hyperplasia (AIMAH) and more rarely adrenocortical adenomas (ACA) have led to the concept of aberrant or illegitimate membrane receptors (AR) in adrenal Cushing syndrome. (endocrine-abstracts.org)
Mutations1
- Somatic mutations in adrenocortical carcinoma with hyperaldosteronism. (cdc.gov)
Incidence3
- Adrenocortical carcinoma (ACC) is a rare tumor with an annual incidence of 2 cases per 1 million population. (cancer.gov)
- Bond lab researchers study the genetic factors associated with the age-dependent incidence of adrenocortical carcinoma. (ox.ac.uk)
- Adrenocortical carcinoma (ACC) is a rare cancer that has two peaks in incidence: between birth and 4 years, and after the 5th decade of life. (ox.ac.uk)
Adenoma1
- The procedure was first described in a patient with Cushing's syndrome due to an adrenocortical adenoma. (amegroups.org)
Therapeutic Targets1
- Therapeutic Targets for Adrenocortical Carcinoma in the Genomics Era. (cdc.gov)
Epidemiology1
- Fassnacht M, Allolio B: Epidemiology of adrenocortical carcinoma. (cancer.gov)
Https1
- Available at: https://www.cancer.gov/types/adrenocortical/patient/adrenocortical-treatment-pdq. (epnet.com)
Adrenal cortex2
- Adrenal carcinomas arise from the adrenal cortex and are bilateral in up to 10% of patients. (medscape.com)
- Adrenocortical carcinoma is cancer that starts in the adrenal cortex. (epnet.com)
Pathological2
- Clay MR, Pinto EM, Fishbein L, Else T, Kiseljak-Vassiliades K. Pathological and Genetic Stratification for Management of Adrenocortical Carcinoma. (ucdenver.edu)
- Oncocytic adrenocortical carcinoma--a rare pathological variant. (edu.in)
Survival1
- Factors associated with survival in pediatric adrenocortical carcinoma: An analysis of the National Cancer Data Base (NCDB). (oncolink.org)
Tumour1
- Current contraindications for LA are adrenocortical carcinomas (ACC) with radiographic evidence of tumour invasion, recurrence of tumour after prior adrenalectomy and severe cardiopulmonary disease ( 4 ). (amegroups.org)
Diagnosis1
- Pitfalls and progress in adrenocortical carcinoma diagnosis: the utility of a multidisciplinary approach, immunohistochemistry and genomics. (cdc.gov)
Prognostic1
- Adrenocortical carcinoma in the United States: treatment utilization and prognostic factors. (cancer.gov)
Patient2
- De Novo Development of a Cortisol-Producing Adrenocortical Carcinoma in a Patient with Primary Adrenal Insufficiency. (foxchase.org)
- [ 9 ] For example, an isolated ipsilateral adrenal metastasis in a patient with resectable, primary, non-small cell lung carcinoma is treated as localized disease. (medscape.com)
TP531
- Penetrance of adrenocortical tumours associated with the germline TP53 R337H mutation. (oncolink.org)
Germline1
Primary1
- A 68-year-old woman with a large right upper quadrant primary adrenocortical carcinoma with curvilinear calcification. (medscape.com)
Characteristics1
- Characteristics of adrenocortical carcinoma associated with Lynch Syndrome. (cdc.gov)
Childhood1
- Ribeiro RC, Figueiredo B: Childhood adrenocortical tumours. (oncolink.org)
Treatment2
- Systemic treatment of adrenocortical carcinoma in children: data from the German GPOH-MET 97 trial. (oncolink.org)
- Adrenocortical carcinoma (ACC) is a rare malignancy without good treatment options. (biomedcentral.com)
Analysis1
- Targeted molecular analysis in adrenocortical carcinomas: a strategy towards improved personalized prognostication. (cdc.gov)
Journal1
- As part of The Cancer Genome Atlas project, the Shmuelvich Lab and colleagues published a paper in the journal Cancer Cell related to the rare cancer adrenocortical carcinoma. (isbscience.org)
Study3
- Minimally Invasive Resection of Adrenocortical Carcinoma: a Multi-Institutional Study of 201 Patients. (ucsf.edu)
- The aim of this study was to assess the association among Twist1, fibronectin, vimentin and E-cadherin gene expression in adrenocortical tumor samples. (bvsalud.org)
- However, few works are dedicated to the study of AS events in esophageal carcinoma (EC). (frontiersin.org)
Outcome1
- Read the summary: 3 Bullets: Adrenocortical carcinoma (ACC) is a rare, under-researched endocrine cancer with limited therapeutic options and overall poor outcome. (isbscience.org)
High1
- T2-weighted MRI demonstrates a large right adrenocortical carcinoma with high signal intensity involving the right lateral aspect. (medscape.com)
System1
- Proposal for modification of the ENSAT staging system for adrenocortical carcinoma using tumor grade. (cancer.gov)