• The term sebaceous neoplasm includes benign and malignant tumors with different degrees of sebaceous differentiation. (medscape.com)
  • Hidradenomas are by definition benign, with malignant transformation very rare. (wikipedia.org)
  • When tumors show malignant characteristics, they are known as hidradenocarcinoma. (wikipedia.org)
  • Surgical excision is usually curative and local recurrences are rare, although malignant tumors may metastasize. (wikipedia.org)
  • ABSTRACT: Multiple primary malignancies (MPMs) refer to the presence of 2 or more histologically distinct malignant tumors in the same individual. (bvsalud.org)
  • Although any combination of malignant tumors is possible, reports of MPMs involving cutaneous carcinoma are uncommon in the literature. (bvsalud.org)
  • Secondary neoplasms - mostly benign and occasionally malignant - can develop within NS, usually in adulthood. (aad.org)
  • Almost all malignant tumors were seen in adults. (aad.org)
  • As no malignant tumors were seen in children, we believe it is reasonable to delay surgical management until adolescence. (aad.org)
  • Intraepidermal Eccrine Adenocarcinomas (IEA) are rare malignant tumors derived from the eccrine sweat glands of the skin. (faoj.org)
  • A benign form of IEA is eccrine acrospiroma, which can transform to a malignant form, especially in inveterate lesions. (faoj.org)
  • Most are malignant except the insulin-producing tumors (INSULINOMA). (lookformedical.com)
  • Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms . (lookformedical.com)
  • It is also employed for the detection of malignant tumors including those of the brain, liver, and thyroid gland. (lookformedical.com)
  • Primary malignant neoplasms of the sweat glands are rare, constituting less than 1% of all primary malignant skin lesions 1 . (bvsalud.org)
  • A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes. (lookformedical.com)
  • Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. (lookformedical.com)
  • A group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes. (lookformedical.com)
  • 1 First described in 1956, poroma was originally identified as a tumor originating from the eccrine sweat gland. (clinicaladvisor.com)
  • Sebaceous glands are holocrine, oil-producing glands present in the dermis of mammalian skin. (medscape.com)
  • Sebaceous glands are usually attached to hair follicles and are part of a complex skin-adnexal unit known as the folliculoapocrine (sweat) apparatus. (medscape.com)
  • Because of the intimate association of sebaceous glands with other adnexal structures in the folliculosebaceous-apocrine unit, many sebaceous neoplasms show complex histopathologic features with mixed sebaceous, pilar (hair), and apocrine (sweat) gland differentiations. (medscape.com)
  • Sebaceous glands are most abundant in the skin of the head and neck regions, particularly in the central face, but they are also present throughout the hair-bearing areas of the body and the mucocutaneous junction, including the labium minus. (medscape.com)
  • The eyelids have modified sebaceous glands (ie, Zeis glands of cilia associated with eyelashes, meibomian glands within the tarsal plates of the upper and lower eyelids). (medscape.com)
  • Using transmission electron microscopy, a small number of melanocytes can be identified that synthesize melanin-containing organelles (melanin granules) in the ducts and acini of human sebaceous glands. (medscape.com)
  • Because of the intimate association of sebaceous glands with hair and apocrine ducts, many sebaceous neoplasms show complex histopathologic features with various elements of pilar and sweat gland differentiation. (medscape.com)
  • It is a benign congenital hamartoma related to abnormalities of the epidermis, sebaceous glands, sweat glands, and hair follicles. (aad.org)
  • Tumors of the cutaneous adnexa arise from, or differentiate toward, structures in normal skin such as hair follicles, sweat ducts/glands, sebaceous glands, or a the disease and results in a specific diagnostic interpretation. (ejmjih.com)
  • Rarely, other malignancies such as sebaceous carcinoma, microcystic adnexal carcinoma, and melanoma may complicate NS. (aad.org)
  • Histologically, a poroma is a well-circumscribed tumor that arises in the lower epidermis and extends into the dermis. (clinicaladvisor.com)
  • The neoplasms may be histologically the same or different, and may be found in the same or different sites. (lookformedical.com)
  • When patients with numerous sebaceous adenomas and/or other neoplasms with sebaceous differentiation have an associated internal malignancy, the clinical condition is known as Muir-Torre syndrome , a subtype of familial nonpolyposis gut carcinoma syndrome, or Lynch syndrome. (medscape.com)
  • Herein, we present 2 uncommon cases of synchronous double primary malignancies involving basal cell carcinoma and primary cutaneous mucinous carcinoma as the index tumors, accompanied by a thyroid carcinoma and a thymoma as the second malignancy, respectively. (bvsalud.org)
  • In contrast to squamous cell carcinoma and basal cell carcinoma, molecular changes in adnexal neoplasia have been poorly characterized, and there are few published reviews on the current state of knowledge. (ejmjih.com)
  • We report 23 cases of tumors of the salivary gland comprising 18 cases of carcinoma ex pleomorphic adenoma, four cases of carcinosarcoma of the parotid and one case of benign metastasizing pleomorphic adenoma. (ijpmonline.org)
  • Given these results, the authors discuss the difficulty in diagnosing differentiation from a primary or metastatic neoplasm of the scalp, with the resources currently available, until the conclusion that it was a primary carcinoma of the sweat gland. (bvsalud.org)
  • breast carcinoma, sweat gland carcinoma, skin cancer. (bvsalud.org)
  • This study aimed to report and discuss the challenging differential diagnosis between a primary tumor of sweat glands and cutaneous metastasis of mammary carcinoma using anatomopathological and imaging diagnostic resources available today. (bvsalud.org)
  • The findings show the challenge in differentiating a primary tumor of the sweat gland from a metastatic cutaneous tumor of mammary carcinoma, even with the immunohistochemical resources currently available. (bvsalud.org)
  • The authors also describe the usefulness of positron emission tomography/computed tomography for detecting occult primary tumors in patients with cutaneous malignancies. (bvsalud.org)
  • Ovarian cancer, uterine cervical cancer, endometrial cancer, and trophoblastic neoplasms are gynecologic malignancies for which tumor markers are in clinical use. (medscape.com)
  • The occurrence of various malignancies suggests that this phenomenon is not very uncommon and should be looked for when reporting a mixed tumor. (ijpmonline.org)
  • Poroma is a benign adnexal neoplasm of the intraepidermal portion of the sweat gland duct, called the acrosyringium . (clinicaladvisor.com)
  • Malignancy arising in mixed tumors of the salivary gland is a distinct entity that can occur sporadically or in association with a background of pleomorphic adenoma. (ijpmonline.org)
  • Many of the sites of these lymphomas, such as the stomach, salivary gland, and thyroid, are normally devoid of lymphoid tissue. (lookformedical.com)
  • Skin adnexal tumors with sebaceous differentiation are uncommon, difficult to classify, and may be controversial. (medscape.com)
  • Therefore, the term sebaceous neoplasm is necessary to include these complex skin adnexal tumors with varying degrees of sebaceous differentiation. (medscape.com)
  • Pilar and sebaceous neoplasms share a common expression for both high and low molecular weight cytokeratin that is not seen in most eccrine or apocrine tumors, pointing to similar cellular differentiation patterns of hair and sebaceous structures. (medscape.com)
  • Poromas are often grouped within the greater classification of acrospiroma, which includes dermal duct tumors, hidroacanthoma simplex, and nodular, clear-cell, and poroid hidradenomas. (clinicaladvisor.com)
  • Hidradenomas are often sub-classified based on subtle histologic differences, for example: Eccrine acrospiroma Clear-cell hidradenoma or acrospiroma Nodular hidradenoma or acrospiroma Solid-cystic hidradenoma Discussion of sweat gland tumors can be difficult and confusing due to the complex classification and redundant terminology used to describe the same tumors. (wikipedia.org)
  • For example, acrospiroma and hidradenoma are synonymous, and sometimes the term acrospiroma is used to generally describe benign sweat gland tumors. (wikipedia.org)
  • Gross pathology of a cystic nodular hidradenoma Dermal duct tumor Acrospiroma, solid type Acrospiroma, clear cell type Wikimedia Commons has media related to Hidradenoma. (wikipedia.org)
  • Acrospiroma is a cutaneous ailment that appears mainly in women and is a kind of benign adnexal neoplasm linked to poromo, a benign skin tumor. (wordinfo.info)
  • 2 With time, it became evident that poromas of an eccrine lineage also exist, but the historic view of poromas as neoplasms of eccrine lineage has persisted such that many poromas are assumed to be eccrine poromas. (clinicaladvisor.com)
  • There has also been a change in understanding about how tumors that were previously believed to strictly derive from specific sweat gland types may, in fact, derive from both eccrine or apocrine glands. (wikipedia.org)
  • ABSTRACT: Intravascular papillary endothelial hyperplasia (Masson tumor) is an uncommon benign vascular lesion characterized by a reactive proliferation of endothelial cells. (bvsalud.org)
  • This report presents a rare case of Masson tumor of the heel fat pad to facilitate the recognition of this uncommon lesion and also suggests other conditions to be considered when diagnosing heel lesions. (bvsalud.org)
  • Skin lesions containing benign sebaceous gland proliferation (eg, sebaceous hyperplasia), congenital hamartomas (eg, nevus sebaceus), and lesions with ectopic sebaceous structures (eg, Fordyce spot, Montgomery tubercles) are generally not considered to be true sebaceous neoplasms. (medscape.com)
  • The authors concluded: "Our study confirms that most of the secondary neoplasms arising in association with nevus sebaceus are benign. (aad.org)
  • Many antigens associated with sweat gland neoplasms, including S-100 protein, CA72.4, gross cystic disease fluid protein 15 (GCDFP-15), and carcinoembryonic antigen (CEA), are absent in sebaceous tumors. (medscape.com)
  • We recently treated an unusual case of pilomatricoma with cystic features in the upper chest of a 9-year-old girl, which manifested as a single solid tumour floating in a serous-filled sac formed by thick fibrous tissue. (bvsalud.org)
  • Ameloblastoma is a benign epithelial odontogenic neoplasm which is common amongst the Yoruba ethinc group. (bvsalud.org)
  • Additional benign neoplasms such as trichoepithelioma (8), tubular apocrine adenomas (9), sebaceomas (1), and others have been reported within NS. (aad.org)
  • This book provides a comprehensive, state-of-the-art account of the role of immunohistochemistry in the diagnosis of skin tumors, which is crucial given that overlapping histologic features and unusual morphologic changes can lead to considerable diagnostic uncertainty. (edu.au)
  • The various tumor markers differ in their usefulness for screening, diagnosis, prognosis, assessing therapeutic response, and detecting recurrence. (medscape.com)
  • Because pathologic diagnosis of ovarian cancer is difficult without laparotomy, tumor markers such as CA-125, in addition to diagnostic imaging, are useful in preoperative evaluation for ovarian cancer. (medscape.com)
  • Clinical diagnosis of Fox-Fordyce disease or appendageal tumors was considered. (ijstd.org)
  • It has a non-debatable contribution to the diagnosis of hematolymphoid neoplasm as well as in minimal residual disease. (ijpmonline.org)
  • This is a unique case due to the low frequency 2 , the atypical clinical history, but mainly the difficult histopathological differential diagnosis and immunohistochemical evaluation among these neoplasms. (bvsalud.org)
  • This paper describes a case of a 71-year-old female who initially went to a dermatologist to assess a scalp skin tumor, which performed an incisional biopsy. (bvsalud.org)
  • A spectrum of morphologic features can be encountered within the same neoplasm. (medscape.com)
  • Indeed, immunohistochemistry has replaced simple morphologic evaluation as the definitive diagnostic method for various tumor types. (edu.au)
  • B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma. (lookformedical.com)
  • Adnexal tumors often present as solitary sporadic lesions, but can herald the presence of an inherited tumor syndrome such as Muir-Torre Syndrome, Cowden Syndrome, or CYLD Cutaneous Syndrome. (ejmjih.com)
  • They are typically produced by tumor cells, but in some cases they may be produced by the body in response to malignancy or to certain benign conditions. (medscape.com)
  • were the first to describe tumors exhibiting features of the epidermal sweat duct. (faoj.org)
  • Solitary fibrous tumor (SFT) has been increasingly reported in various anatomic sites. (cn1699.cn)
  • Beta-hCG and alpha-fetoprotein have proved to be useful markers for ovarian germ cell tumors. (medscape.com)
  • Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. (lookformedical.com)
  • Overproduction of prolactin by the pituitary gland can cause galactorrhea (excessive or abnormal lactation) and amenorrhea (absence of menstruation). (rnpedia.com)
  • Their molecular footprint often reflects the histologic tumor type, and familiarity with these changes will be increasingly necessary for diagnostic and therapeutic considerations. (ejmjih.com)
  • No tumor markers with high sensitivity and high specificity for endometrial cancer are known at present, although CA-125 is often used in clinical practice. (medscape.com)
  • The prevalence of MPMs has increased owing to earlier detection of tumors by screening tests and improved treatment modalities for primary tumors. (bvsalud.org)
  • Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system. (lookformedical.com)
  • The sebaceous gland is a secretory structure consisting of sebaceous lobules and ducts. (medscape.com)
  • The prevalence of poroma is not clearly defined, but it is regarded as a relatively rare tumor. (clinicaladvisor.com)
  • A consistent increase in a tumor marker value, combined with lack of clinical improvement, may indicate treatment failure. (medscape.com)
  • The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. (lookformedical.com)
  • B-cell lymphoid tumors that occur in association with AIDS. (lookformedical.com)
  • The incidence of secondary neoplasms was statistically related to age and anatomic site (P (aad.org)
  • In summary, molecular alterations in cutaneous neoplasms of the head and neck are often related to UV exposure. (ejmjih.com)
  • Molecular genetics and immunopathologic analysis of bladder cancer have shown some abnormalities in a number of genes and proteins that have been implicated in the development and progression of such tumors, mainly in the p53 pathway. (ijpmonline.org)
  • This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth. (lookformedical.com)
  • The glands are present over the entire body, with the exception of the palms of the hands and the soles of the feet. (medscape.com)
  • The tumors are often disseminated in unusual extranodal sites and chromosomal abnormalities are frequently present. (lookformedical.com)
  • Furthermore, the architectural features of sebaceous tumors resemble those of pilar neoplasms, and not those of sweat gland tumors. (medscape.com)
  • Therefore, antigenic similarities exist between the isthmus of the outer hair sheath and the germinative basaloid cells of the sebaceous gland. (medscape.com)
  • The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease. (lookformedical.com)
  • Tumor markers are soluble glycoproteins that are found in the blood, urine, or tissues of patients with certain types of cancer. (medscape.com)
  • Tumor markers are not elevated in all cancer patients, particularly patients with early-stage cancer. (medscape.com)
  • Tumors or cancer of the PANCREAS. (lookformedical.com)
  • Tumors or cancer of the LUNG. (lookformedical.com)
  • Tumors or cancer of the LIVER. (lookformedical.com)