• Syringocystadenoma papilliferum is a rare non-malignant adnexal neoplasm that develops from apocrine or eccrine sweat glands and can be identified histologically by cystic, papillary, and ductal invaginations into the dermis lined by double-layered outer cuboidal and luminal high columnar epithelium and connected to the epidermis. (wikipedia.org)
  • Carcinomas of the eccrine sweat gland represent a rare group of tumors with potential for local destruction and metastasis. (medscape.com)
  • The authors hypothesize that this difference may be partly explained by the fact that the bulk of eccrine sweat glands lie deep in the dermis, an environment relatively protected from the sun and environmental mutagens. (medscape.com)
  • 1 First described in 1956, poroma was originally identified as a tumor originating from the eccrine sweat gland. (clinicaladvisor.com)
  • Intraepidermal Eccrine Adenocarcinomas (IEA) are rare malignant tumors derived from the eccrine sweat glands of the skin. (faoj.org)
  • Eccrine sweat glands are one of the major sweat glands found in humans. (biomedcentral.com)
  • Eccrine sweat glands are innervated by postganglionic sympathetic fibers, and their major function is thermoregulation via evaporative heat loss and electrolyte balance [ 1 ]. (biomedcentral.com)
  • Poroma is a benign sweat gland tumour showing morphological features recapitulating the superficial portion of the eccrine sweat coil. (bvsalud.org)
  • The specific classification of eccrine carcinomas is both complex and nebulous, mostly because of the paucity of reported cases but also because many of these tumors show little histologic resemblance to mature eccrine glands. (medscape.com)
  • [ 1 ] who divide these tumors into those that arise de novo in normal skin and those that originate within preexisting benign sweat gland tumors. (medscape.com)
  • [ 2 ] examining the incidence of cytogenetic abnormalities in malignant eccrine tumors showed low incidences of loss of heterozygosity (LOH) or TP53 alterations in a mixed group of these neoplasms, in contrast to the frequent and multiple genetic abnormalities seen in tumors arising from epidermal keratinocytes. (medscape.com)
  • Multiple familial trichoepithelioma is a condition involving multiple skin tumors that develop from structures associated with the skin (skin appendages), such as hair follicles and sweat glands. (medlineplus.gov)
  • Affected individuals are also at increased risk of developing tumors in tissues other than skin appendages, particularly benign or malignant tumors of the salivary glands. (medlineplus.gov)
  • were the first to describe tumors exhibiting features of the epidermal sweat duct. (faoj.org)
  • Thus, appropriate classification of such sweat glands, and associated tumors, enables us to devise a specific and appropriate sweat gland tumor therapeutical plan, and also an associated precise prognosis, i.e. apocrine carcinomas are able to metastasize to regional lymph nodes and do so frequently, whereas eccrine carcinomas are typically not able to metastasize [ 4 ]. (biomedcentral.com)
  • Six tumors had sheets of atypical melanocytes infiltrating the dermis and were classified as melanomas. (bvsalud.org)
  • Recurrent oncogenic drivers have been identified in a variety of sweat gland tumors. (bvsalud.org)
  • The main objectives of the present study were (i) to provide an overview of the prevalence of previously identified oncogenic drivers in acral sweat gland tumors and (ii) to genetically characterize tumors in which no recurrent genetic alteration has been identified yet. (bvsalud.org)
  • Cases of acral sweat gland tumors were identified from the database of the French network CARADERM. (bvsalud.org)
  • Females are at risk for sex cord tumors with annular tubules (SCTAT), a benign neoplasm of the ovaries, and adenoma malignum of the cervix, a rare aggressive cancer. (beds.ac.uk)
  • Primary mucinous carcinoma (PMC) of the skin is a rare malignant neoplasm deriving from sweat glands [ 1 ]. (cdlib.org)
  • Given these results, the authors discuss the difficulty in diagnosing differentiation from a primary or metastatic neoplasm of the scalp, with the resources currently available, until the conclusion that it was a primary carcinoma of the sweat gland. (bvsalud.org)
  • breast carcinoma, sweat gland carcinoma, skin cancer. (bvsalud.org)
  • This study aimed to report and discuss the challenging differential diagnosis between a primary tumor of sweat glands and cutaneous metastasis of mammary carcinoma using anatomopathological and imaging diagnostic resources available today. (bvsalud.org)
  • The findings show the challenge in differentiating a primary tumor of the sweat gland from a metastatic cutaneous tumor of mammary carcinoma, even with the immunohistochemical resources currently available. (bvsalud.org)
  • Eccrine carcinoma is a quite rare malignant tumor that typically arises from a normal sweat gland and that features a rather high recurrence rate subsequent to simple excision. (biomedcentral.com)
  • Eccrine carcinoma is a rare, malignant sweat gland tumor, generally featuring a slow growth rate and a rather high local recurrence rate [ 2 ]. (biomedcentral.com)
  • Sweat gland carcinomas were first reported by Stout and Cooley in 1951 with the observation that, "sweat gland carcinoma often developed at the site of pre-existing nodules of longstanding and they have a propensity to metastasize" [ 2 ]. (biomedcentral.com)
  • Appropriate sweat gland carcinoma classification is clearly important since each of the specific sweat gland carcinomas features its own characteristic biological behavior [ 4 ]. (biomedcentral.com)
  • Given its rather poor response to adjuvant therapy, wide excision of the lesion with tumor-free margins may offer a reasonable chance for long-term control of this neoplasm. (biomedcentral.com)
  • When two distinct neoplasms are located adjacent to the same cutaneous site, the phenomenon is commonly referred to as a collision tumor [ 1 , 2 ]. (e-acfs.org)
  • Poroma is a benign adnexal neoplasm of the intraepidermal portion of the sweat gland duct, called the acrosyringium . (clinicaladvisor.com)
  • The retrocommissural region is situated between the labial commissure and the opening of Stensen's duct (the drainage duct of the parotid gland), located opposite the second upper molar (see the images below). (medscape.com)
  • Each gland has a single duct that emerges from a cluster of oval alveoli. (wakehealth.edu)
  • However, research shows UVR is known to suppress sweating, which disrupts body thermoregulation, and a study analyzing TP53 mutations in 16 sweat gland carcinomas identified 3 G:C → A:T transitions at dipyrimidine sequences on the antisense strand. (medscape.com)
  • The first large study pertaining to the classification of sweat gland carcinomas was published in 1968 by Berg and McDivitt [ 3 ]. (biomedcentral.com)
  • Unfortunately, as far as we are aware, sweat gland carcinomas are often under diagnosed or misdiagnosed due to their clinical rarity [ 8 ]. (biomedcentral.com)
  • Primary malignant skin neoplasms most often are carcinomas (either basal cell or squamous cell carcinomas) or melanomas. (nih.gov)
  • Metastatic malignant neoplasms to the skin include carcinomas and lymphomas. (nih.gov)
  • Cutaneous polyarteritis nodosa (CPN) is an uncommon form of vasculitis of the small-and medium-sized arteries in the reticular dermis and subcutaneous tissue. (annals.edu.sg)
  • We report the clinical and histologic presentation of 51 cutaneous melanocytic neoplasms with a PKC fusion gene (involving PRKCA in 35 cases, PRKCB in 15 cases, and PRKCG in a single case). (bvsalud.org)
  • A threadlike specialized epidermal structure developing from a papilla sunk in the dermis. (easyauscultation.com)
  • The main histological findings in the skin and subcutaneous cellular tissue of the irradiated breast were as follows: epidermal hyperplasia, flattening of the papillary layer, atrophy of the skin appendages, vascular congestion in fatty tissue, high density of skin collagen fibers, hyalinization, and reduction of elastic fibers in the deep dermis and unidirectional alignment of collagen fibers. (rbcp.org.br)
  • Lymphocytic infiltrate and abundant melanophages in papillary dermis are additional findings. (webpathology.com)
  • Additional benign neoplasms such as trichoepithelioma (8), tubular apocrine adenomas (9), sebaceomas (1), and others have been reported within NS. (aad.org)
  • The authors concluded: "Our study confirms that most of the secondary neoplasms arising in association with nevus sebaceus are benign. (aad.org)
  • A group of disorders characterized by swelling, basophilia, and distortion of collagen bundles in the dermis. (bvsalud.org)
  • The incidence of secondary neoplasms was statistically related to age and anatomic site (P (aad.org)
  • Salivary Gland Polymorphous Adenocarcinoma: Clinicopathological Features and Gene Alterations in 36 Japanese Patients. (nagoya-u.ac.jp)
  • The pathogenesis of leiomyoma is characterized by benign smooth muscle neoplasm . (wikidoc.org)
  • Neutrophilic eccrine hidradenitis (NEH) is a neutrophilic dermatosis primarily affecting the eccrine glands and occurs most commonly in patients undergoing chemotherapy for a malignancy. (annals.edu.sg)
  • Skin biopsy from the papular lesion revealed multiple ductal structures seen in the dermis. (ijstd.org)
  • The major salivary glands are in close relation with oral cavity structures, although they are not part of the oral cavity. (medscape.com)
  • This is a unique case due to the low frequency 2 , the atypical clinical history, but mainly the difficult histopathological differential diagnosis and immunohistochemical evaluation among these neoplasms. (bvsalud.org)
  • We aimed to review the clinical, morphological and molecular features of this category of adnexal neoplasms with a special focus upon emerging differential diagnoses, and discuss how their systematic molecular characterisation may contribute to a standardisation of diagnosis, more accurate classification and, ultimately, refinement of their prognosis and therapeutic modalities. (bvsalud.org)
  • This graph shows the total number of publications written about "Sebaceous Glands" by people in this website by year, and whether "Sebaceous Glands" was a major or minor topic of these publications. (wakehealth.edu)