• The less common subtypes include eccrine mucinous carcinoma, malignant eccrine spiradenoma, malignant mixed tumor, malignant cylindroma, and papillary eccrine adenoma. (medscape.com)
  • Immunosuppression has been known to increase the risk of nonmelanoma skin cancers, particularly squamous cell carcinomas. (medscape.com)
  • Biopsy of the area confirmed squamous cell carcinoma (SCC), stage 1. (appliedradiationoncology.com)
  • 3 Histologically, the absence of keratinizing cysts and squamous differentiation (ie, islands with parakeratotic keratinization) distinguish SC from other sclerosing adnexal tumors such as microcystic adnexal carcinoma (MAC) and squamoid eccrine ductal carcinoma (SEDC), respectively. (appliedradiationoncology.com)
  • 9 The documented link between previous radiation and developing MAC suggests that mutagenesis caused by radiation treatment for this patient's squamous cell carcinoma likely contributed to the development of syringomatous carcinoma. (appliedradiationoncology.com)
  • This report presents a unique case of likely radiation-induced syringomatous carcinoma in a patient previously treated with radiation for a left intranasal squamous cell carcinoma. (appliedradiationoncology.com)
  • Nasopharyngeal carcinomas (NPC) are non-keratinizing squamous cell carcinomas of the nasopharynx associated with Epstein-Barr virus (EBV). (researchgate.net)
  • Squamous cell carcinomas (SCCs) at high risk for local recurrence or metastasis are best treated with Mohs surgery. (medscape.com)
  • described a case of squamous cell carcinoma in situ occurring within a clear cell acanthoma. (statpearls.com)
  • Primary malignant skin neoplasms most often are carcinomas (either basal cell or squamous cell carcinomas) or melanomas. (nih.gov)
  • Carcinomas of the eccrine sweat gland represent a rare group of tumors with potential for local destruction and metastasis. (medscape.com)
  • The specific classification of eccrine carcinomas is both complex and nebulous, mostly because of the paucity of reported cases but also because many of these tumors show little histologic resemblance to mature eccrine glands. (medscape.com)
  • [ 1 ] who divide these tumors into those that arise de novo in normal skin and those that originate within preexisting benign sweat gland tumors. (medscape.com)
  • [ 2 ] examining the incidence of cytogenetic abnormalities in malignant eccrine tumors showed low incidences of loss of heterozygosity (LOH) or TP53 alterations in a mixed group of these neoplasms, in contrast to the frequent and multiple genetic abnormalities seen in tumors arising from epidermal keratinocytes. (medscape.com)
  • [ 8 ] suggest that patients who are immunosuppressed have a propensity to also develop cutaneous appendageal tumors over their immunocompetent counterparts, with increased rates of both benign eccrine tumors and malignant eccrine tumors. (medscape.com)
  • Eccrine carcinoma tumors are locally aggressive, with a high rate of recurrence. (wikipedia.org)
  • Lack of reliable immunohistochemical markers and similarity to other common tumors has made identification of eccrine carcinoma difficult. (wikipedia.org)
  • Other tumors not classified include eccrine ductal carcinoma, basaloid eccrine carcinoma, clear cell eccrine carcinoma and non-specified sweat gland carcinomas. (wikipedia.org)
  • Even though eccrine carcinomas would appear to be rare, when dealing with recurrent skin tumors or recurrent perianal fistulas, the possibility of eccrine carcinoma should be considered by consulting clinicians. (biomedcentral.com)
  • Thus, appropriate classification of such sweat glands, and associated tumors, enables us to devise a specific and appropriate sweat gland tumor therapeutical plan, and also an associated precise prognosis, i.e. apocrine carcinomas are able to metastasize to regional lymph nodes and do so frequently, whereas eccrine carcinomas are typically not able to metastasize [ 4 ]. (biomedcentral.com)
  • Intraepidermal Eccrine Adenocarcinomas (IEA) are rare malignant tumors derived from the eccrine sweat glands of the skin. (faoj.org)
  • were the first to describe tumors exhibiting features of the epidermal sweat duct. (faoj.org)
  • Objective: Laryngeal verrucous carcinoma (LVC) comprises 1% to 4% of all laryngeal tumors. (researchgate.net)
  • After an incisional biopsy, her sample was firstly sent for anatomopathological study in a first pathology laboratory, chosen by the dermatologist, with the diagnostic hypothesis of basal cell carcinoma. (bvsalud.org)
  • Basal cell carcinoma (BCC), which arises from the basal cells in the epidermis, is the most common form of skin cancer. (e-acfs.org)
  • Fibroepitheliomatous Paget's phenomenon: fibroepithelioma-like changes associated with anogenital epidermotropic mucinous carcinoma. (markahurt.com)
  • Endocrine mucin-producing sweat gland carcinoma (EMPSGC) and primary cutaneous mucinous carcinoma (PCMC) are rare low-grade neoplasms thought to arise from apocrine glands that share many histological features and are proposed to be on a single histopathologic continuum, with EMPSGC as the in situ form that may progress to the invasive PCMC. (bvsalud.org)
  • A benign form of IEA is eccrine acrospiroma, which can transform to a malignant form, especially in inveterate lesions. (faoj.org)
  • Anatomopathological and immunohistochemical study revealed a preliminary diagnosis of breast carcinoma metastasis. (bvsalud.org)
  • Lymph node involvement is typically rare for eccrine carcinoma but distal metastasis is not uncommon [ 4 ]. (biomedcentral.com)
  • New anatomopathological and immunohistochemical exams confirmed the diagnosis of breast carcinoma metastasis. (bvsalud.org)
  • This study aimed to report and discuss the challenging differential diagnosis between a primary tumor of sweat glands and cutaneous metastasis of mammary carcinoma using anatomopathological and imaging diagnostic resources available today. (bvsalud.org)
  • The anatomopathological report indicated breast carcinoma metastasis and the pathologist recommended a further immunohistochemical investigation to determine the neoplastic site of origin. (bvsalud.org)
  • Patient developed infiltrating ductal carcinoma of underlying breast tissue with axillary lymph metastasis. (medscape.com)
  • It is unclear whether clear cell acanthoma represents a benign neoplasm or a reactive inflammatory dermatosis. (statpearls.com)
  • 4] Evidence concerning the intraepidermal portion of the eccrine duct was initially presented in 1939 by Pinkus. (faoj.org)
  • RESULTS: We found that tissue samples from patients with InfAIGA exhibited inflammation within the sweat duct and atrophy of the sweat coil, whereas patients with non-InfAIGA exhibited only atrophy of the sweat coil. (bvsalud.org)
  • CONCLUSIONS: InfAIGA is associated with increased sweat duct inflammation and sweat coil atrophy, whereas non-InfAIGA is only associated with sweat coil atrophy. (bvsalud.org)
  • Exceptions to this are the malignant chondroid syringoma and primary cutaneous adenoid cystic eccrine carcinoma, both of which occur more commonly in females than in males. (medscape.com)
  • High recurrence rates have been reported following conventional surgical excision of eccrine carcinomas. (medscape.com)
  • Most eccrine carcinomas which have not spread can be cured by wide local excision. (wikipedia.org)
  • Eccrine carcinoma is a quite rare malignant tumor that typically arises from a normal sweat gland and that features a rather high recurrence rate subsequent to simple excision. (biomedcentral.com)
  • Given its rather poor response to adjuvant therapy, wide excision of the lesion with tumor-free margins may offer a reasonable chance for long-term control of this neoplasm. (biomedcentral.com)
  • Patient was treated by conservative excision of lesion and lumpectomy for in situ carcinoma. (medscape.com)
  • Eccrine carcinoma is a rare, malignant sweat gland tumor, generally featuring a slow growth rate and a rather high local recurrence rate [ 2 ]. (biomedcentral.com)
  • Background: Aquaporin (AQP) expression has been investigated in various malignant neoplasms, and the overexpression of AQP is related to poor prognosis in some malignancies. (koreamed.org)
  • Primary eccrine carcinomas are exceedingly rare, accounting for roughly 1 of 13,000 specimens submitted to a dermatopathology laboratory. (medscape.com)
  • Although the patient had no medical history of breast cancer, due to this result, she was referred to a mastologist, who investigated her breast nodules for the possible primary focus of the carcinoma. (bvsalud.org)
  • Given these results, the authors discuss the difficulty in diagnosing differentiation from a primary or metastatic neoplasm of the scalp, with the resources currently available, until the conclusion that it was a primary carcinoma of the sweat gland. (bvsalud.org)
  • The findings show the challenge in differentiating a primary tumor of the sweat gland from a metastatic cutaneous tumor of mammary carcinoma, even with the immunohistochemical resources currently available. (bvsalud.org)
  • BACKGROUND: Primary focal hyperhidrosis (PFH) may be attributed to the up-regulation of the cholinergic receptor nicotinic alpha 1 subunit (CHRNA1) in eccrine glands. (bvsalud.org)
  • A primary or metastatic malignant neoplasm involving the skin. (nih.gov)
  • For those that consider this entity to be a tumor, there is further disagreement whether this is a tumor of epidermal, pilar, or sweat gland origin. (statpearls.com)
  • Histology results showed inadequate samples in six and Bronchogenic carcinoma in four patients. (bvsalud.org)
  • These data suggest that inflammation leads to epithelial destruction of sweat ducts associated with the sweat coil atrophy and subsequent loss of function. (bvsalud.org)
  • Ameloblastoma is a benign epithelial odontogenic neoplasm which is common amongst the Yoruba ethinc group. (bvsalud.org)
  • The authors hypothesize that this difference may be partly explained by the fact that the bulk of eccrine sweat glands lie deep in the dermis, an environment relatively protected from the sun and environmental mutagens. (medscape.com)
  • Neutrophilic eccrine hidradenitis (NEH) is a neutrophilic dermatosis primarily affecting the eccrine glands and occurs most commonly in patients undergoing chemotherapy for a malignancy. (annals.edu.sg)
  • Unfortunately, as far as we are aware, sweat gland carcinomas are often under diagnosed or misdiagnosed due to their clinical rarity [ 8 ]. (biomedcentral.com)
  • This is a unique case due to the low frequency 2 , the atypical clinical history, but mainly the difficult histopathological differential diagnosis and immunohistochemical evaluation among these neoplasms. (bvsalud.org)
  • CONCLUSION: PAI1 inhibits CHRNA1-mediated hydrochloride-induced hyperhidrosis, with decreased sweat gland secretion and diminished ACH, AQP5, and CACNA1C expression. (bvsalud.org)
  • Eccrine carcinoma may be derived de novo from any portion of the normal eccrine apparatus or result from the transformation of an existing benign eccrine tumor. (medscape.com)