• Although any combination of malignant tumors is possible, reports of MPMs involving cutaneous carcinoma are uncommon in the literature. (bvsalud.org)
  • Herein, we present 2 uncommon cases of synchronous double primary malignancies involving basal cell carcinoma and primary cutaneous mucinous carcinoma as the index tumors, accompanied by a thyroid carcinoma and a thymoma as the second malignancy, respectively. (bvsalud.org)
  • The most common malignant neoplasm arising in this disorder is basal cell carcinoma. (medscape.com)
  • Studies indicate that the development of basal cell carcinoma or any other malignant neoplasm is very rare. (medscape.com)
  • Other benign and malignant tumors include syringocystadenoma papilliferum arising from the apocrine sweat glands, keratoacanthoma , apocrine cystadenoma , leiomyoma , and sebaceous cell carcinoma. (medscape.com)
  • This was due to misdiagnosis of basal cell carcinomas that were in fact trichoblastomas (benign form of neoplasm that look like basal cell carcinoma histologically). (medscape.com)
  • Its therapeutic use is limited to the treatment of hypercalcemia and Paget's osteopathy, and as a tumor marker in medullary carcinoma. (teknon.es)
  • Trichoepitheliomas are generally noncancerous (benign) but occasionally develop into a type of skin cancer called basal cell carcinoma . (medlineplus.gov)
  • Such features are seen in eosinophilic chromophobe carcinoma, a malignant tumor that can mimic oncocytoma. (promisekit.org)
  • Given these results, the authors discuss the difficulty in diagnosing differentiation from a primary or metastatic neoplasm of the scalp, with the resources currently available, until the conclusion that it was a primary carcinoma of the sweat gland. (bvsalud.org)
  • breast carcinoma, sweat gland carcinoma, skin cancer. (bvsalud.org)
  • This study aimed to report and discuss the challenging differential diagnosis between a primary tumor of sweat glands and cutaneous metastasis of mammary carcinoma using anatomopathological and imaging diagnostic resources available today. (bvsalud.org)
  • The findings show the challenge in differentiating a primary tumor of the sweat gland from a metastatic cutaneous tumor of mammary carcinoma, even with the immunohistochemical resources currently available. (bvsalud.org)
  • Objective: Laryngeal verrucous carcinoma (LVC) comprises 1% to 4% of all laryngeal tumors. (researchgate.net)
  • Proper recognition of this disorder is required to initiate an appropriate workup (eg, skin biopsy) for differentiating it from other benign inflammatory dermatoses and for detecting an underlying breast carcinoma. (medscape.com)
  • We report 23 cases of tumors of the salivary gland comprising 18 cases of carcinoma ex pleomorphic adenoma, four cases of carcinosarcoma of the parotid and one case of benign metastasizing pleomorphic adenoma. (ijpmonline.org)
  • Eccrine carcinoma is a quite rare malignant tumor that typically arises from a normal sweat gland and that features a rather high recurrence rate subsequent to simple excision. (biomedcentral.com)
  • Even though eccrine carcinomas would appear to be rare, when dealing with recurrent skin tumors or recurrent perianal fistulas, the possibility of eccrine carcinoma should be considered by consulting clinicians. (biomedcentral.com)
  • Eccrine carcinoma is a rare, malignant sweat gland tumor, generally featuring a slow growth rate and a rather high local recurrence rate [ 2 ]. (biomedcentral.com)
  • Sweat gland carcinomas were first reported by Stout and Cooley in 1951 with the observation that, "sweat gland carcinoma often developed at the site of pre-existing nodules of longstanding and they have a propensity to metastasize" [ 2 ]. (biomedcentral.com)
  • Appropriate sweat gland carcinoma classification is clearly important since each of the specific sweat gland carcinomas features its own characteristic biological behavior [ 4 ]. (biomedcentral.com)
  • These features might lead to an erroneous diagnosis of high-grade renal cell carcinoma, particularly since intra-tumoral fat can occur in these tumors [ 4 ]. (biomedcentral.com)
  • By definition, pseudomesotheliomatous carcinoma refers to an epithelial neoplasm that secondarily involves the pleura and encases the lung, thereby simulating the radiologic and macroscopic appearance of malignant mesothelioma. (medscape.com)
  • The risk of cancer in a major salivary gland in inversely proportional to the size of the gland. (thyroidheadnecksurgery.com)
  • Malignancy arising in mixed tumors of the salivary gland is a distinct entity that can occur sporadically or in association with a background of pleomorphic adenoma. (ijpmonline.org)
  • Many of the sites of these lymphomas, such as the stomach, salivary gland, and thyroid, are normally devoid of lymphoid tissue. (lookformedical.com)
  • Microscopically it is a mixed tumor, characterized by prominent chondroid or myxoid stroma enveloping benign bland appearing epithelial and myoepithelial cells. (wikipedia.org)
  • Parotid gland oncocytoma is an uncommon, benign salivary neoplasm composed of mitochondria-rich epithelial cells called oncocytes. (promisekit.org)
  • A benign epithelial tumor with a glandular organization. (curehunter.com)
  • Ameloblastoma is a benign epithelial odontogenic neoplasm which is common amongst the Yoruba ethinc group. (bvsalud.org)
  • ABSTRACT: Intravascular papillary endothelial hyperplasia (Masson tumor) is an uncommon benign vascular lesion characterized by a reactive proliferation of endothelial cells. (bvsalud.org)
  • This report presents a rare case of Masson tumor of the heel fat pad to facilitate the recognition of this uncommon lesion and also suggests other conditions to be considered when diagnosing heel lesions. (bvsalud.org)
  • In 1895, Jadassohn first described nevus sebaceous (see the image below), a circumscribed hamartomatous lesion predominantly composed of sebaceous glands. (medscape.com)
  • the conspicuity of these lesions can be reduced due to a combination of the high density of the parotid gland and weak enhancement of the lesion. (promisekit.org)
  • Hypertrichosis and/or excessive sweating overlaying the lesion further supports a diagnosis of tufted angioma. (medscape.com)
  • Given its rather poor response to adjuvant therapy, wide excision of the lesion with tumor-free margins may offer a reasonable chance for long-term control of this neoplasm. (biomedcentral.com)
  • Adrenocortical adenoma  encapsulated, expansile, yellow tumors, lipid-rich cells, adjacent adrenal cortex and contralateral adrenal glands are atrophic b/c of suppression of endogenous ACTH by high cortisol levels. (docsbay.net)
  • aldosterone secreting adenoma in one adrenal gland. (docsbay.net)
  • however, they can be seen with other sweat gland tumors such as cylindromas and trichoepitheliomas as part of Brooke-Spiegler syndrome, in which lesions may have combined features of cylindromas and spiradenomas. (medscape.com)
  • Prognosis is excellent for these lesions as they are benign. (statpearls.com)
  • Many carcinomas are solid, while several cystic or mixed lesions are benign. (teknon.es)
  • Adnexal tumors often present as solitary sporadic lesions, but can herald the presence of an inherited tumor syndrome such as Muir-Torre Syndrome, Cowden Syndrome, or CYLD Cutaneous Syndrome. (ejmjih.com)
  • Primary malignant neoplasms of the sweat glands are rare, constituting less than 1% of all primary malignant skin lesions 1 . (bvsalud.org)
  • This case illustrates the importance of recognizing the possibility of multiple skin cancers, even in patients with benign lesions such as capillary malformations. (e-acfs.org)
  • A benign form of IEA is eccrine acrospiroma, which can transform to a malignant form, especially in inveterate lesions. (faoj.org)
  • 1 First described in 1956, poroma was originally identified as a tumor originating from the eccrine sweat gland. (clinicaladvisor.com)
  • Alterations in the beta-catenin pathway, which is involved in several epidermal tumors, are thought to play a role. (medscape.com)
  • For those that consider this entity to be a tumor, there is further disagreement whether this is a tumor of epidermal, pilar, or sweat gland origin. (statpearls.com)
  • Most experts maintain that clear cell acanthoma is an epidermal tumor, as originally described. (statpearls.com)
  • were the first to describe tumors exhibiting features of the epidermal sweat duct. (faoj.org)
  • At 5-year follow-up, she was alive, without recurrent or metastatic tumor. (medscape.com)
  • No metastatic tumor was noted in axillary lymph node. (medscape.com)
  • Majority of these pheochromocytomas are benign in origin and only a few cases develop malignancy. (targetwoman.com)
  • The conversion to a malignant pancreatic tumor (malignancy). (vsebolezni.com)
  • mini-invasive laparoscopic surgery (with a small education that is concentrated in the tail of the gland, with no symptoms of malignancy). (vsebolezni.com)
  • Porocarcinoma is a malignancy of the eccrine sweat gland. (koreamed.org)
  • Therefore, such a process often leads to malignancy, that is, the development of a malignant tumor. (medhelpsis.com)
  • In addition, prognostic markers are evaluated and emphasis placed on the pitfalls commonly encountered when evaluating these neoplasms. (edu.au)
  • When two distinct neoplasms are located adjacent to the same cutaneous site, the phenomenon is commonly referred to as a collision tumor [ 1 , 2 ]. (e-acfs.org)
  • The glands ( lymph nodes ) on either side of the neck, under the jaw, or behind the ears commonly swell when you have a cold or sore throat. (healthlinkbc.ca)
  • Swollen glands commonly develop when the body fights infections from colds, insect bites, or small cuts. (healthlinkbc.ca)
  • Schwannomas are benign, slow-growing peripheral nerve sheath tumors commonly occurring in the head, neck, and flexor regions of the extremities. (koreamed.org)
  • Synovial sarcoma is a malignant soft-tissue neoplasm that most commonly affects the extremities near to, but not in continuity with, large joints. (medscape.com)
  • This class of neoplasms includes benign tumors and highly aggressive carcinomas. (ejmjih.com)
  • The first large study pertaining to the classification of sweat gland carcinomas was published in 1968 by Berg and McDivitt [ 3 ]. (biomedcentral.com)
  • Thus, appropriate classification of such sweat glands, and associated tumors, enables us to devise a specific and appropriate sweat gland tumor therapeutical plan, and also an associated precise prognosis, i.e. apocrine carcinomas are able to metastasize to regional lymph nodes and do so frequently, whereas eccrine carcinomas are typically not able to metastasize [ 4 ]. (biomedcentral.com)
  • Unfortunately, as far as we are aware, sweat gland carcinomas are often under diagnosed or misdiagnosed due to their clinical rarity [ 8 ]. (biomedcentral.com)
  • Poroma is a benign adnexal neoplasm of the intraepidermal portion of the sweat gland duct, called the acrosyringium . (clinicaladvisor.com)
  • Acrospiroma is a cutaneous ailment that appears mainly in women and is a kind of benign adnexal neoplasm linked to poromo, a benign skin tumor. (wordinfo.info)
  • Individuals with multiple familial trichoepithelioma occasionally also develop other types of tumors, including growths called spiradenomas and cylindromas. (medlineplus.gov)
  • Neoplasms are tumorous growths, that may be either benign (non-cancerous) or malignant (cancerous). (thyroidheadnecksurgery.com)
  • Benign growths are very rare. (vsebolezni.com)
  • The thyroid gland weighs, on average, 15 g, and is composed of two lateral lobes that extend to the sides of the larynx to very close to the midline of the thyroid cartilage, and that are joined by an isthmus that pass in front of the trachea. (teknon.es)
  • An enlarged thyroid gland ( goiter ) is in the neck just below the Adam's apple. (healthlinkbc.ca)
  • Multinodular goiter (MNG) is the most common disorder of the thyroid gland. (intechopen.com)
  • It starts as a diffuse enlargement of the thyroid gland and ends in a nodular enlarged thyroid. (intechopen.com)
  • Goiter is the enlargement of the thyroid gland which can be due to a variety of conditions. (intechopen.com)
  • Nodular goiter is one of the most common endocrine disorders affecting the thyroid gland. (intechopen.com)
  • The thyroid gland secretes about 8 micrograms of T3/day, but 40 micrograms of T3 is made overall. (cdc.gov)
  • Poromas are often grouped within the greater classification of acrospiroma, which includes dermal duct tumors, hidroacanthoma simplex, and nodular, clear-cell, and poroid hidradenomas. (clinicaladvisor.com)
  • It's related to acrospiroma (also called poroma), a tumor of the distal part of the sweat gland. (facmedicine.com)
  • The most frequent benign tumor is trichoblastoma. (medscape.com)
  • Hyperthyroidism with small diffuse or nodular goiter, small uni or multinodular goiter, asymptomatic and benign, hypothyroidism presents a good response to medical treatment. (teknon.es)
  • SFTs of the pleura are localized mesenchymal neoplasms composed of fibroblastlike cells believed to arise from the subpleural connective tissue. (medscape.com)
  • This book provides a comprehensive, state-of-the-art account of the role of immunohistochemistry in the diagnosis of skin tumors, which is crucial given that overlapping histologic features and unusual morphologic changes can lead to considerable diagnostic uncertainty. (edu.au)
  • This is a unique case due to the low frequency 2 , the atypical clinical history, but mainly the difficult histopathological differential diagnosis and immunohistochemical evaluation among these neoplasms. (bvsalud.org)
  • To clarify the diagnosis, your doctor mayguide for computed tomography, magnetic resonance imaging, to offer to take the General and biochemical blood analysis, blood test for tumor markers, etc. (vsebolezni.com)
  • It has a non-debatable contribution to the diagnosis of hematolymphoid neoplasm as well as in minimal residual disease. (ijpmonline.org)
  • Clinical diagnosis of Fox-Fordyce disease or appendageal tumors was considered. (ijstd.org)
  • If such a tumor does not stain for HMB-45 or Melan-A, a specific diagnosis of epithelioid pleomorphic angiomyolipoma cannot be made with certainty. (biomedcentral.com)
  • It is a benign congenital hamartoma related to abnormalities of the epidermis, sebaceous glands, sweat glands, and hair follicles. (aad.org)
  • Tumors of the cutaneous adnexa arise from, or differentiate toward, structures in normal skin such as hair follicles, sweat ducts/glands, sebaceous glands, or a the disease and results in a specific diagnostic interpretation. (ejmjih.com)
  • Multiple familial trichoepithelioma is a condition involving multiple skin tumors that develop from structures associated with the skin (skin appendages), such as hair follicles and sweat glands. (medlineplus.gov)
  • People with multiple familial trichoepithelioma typically develop large numbers of smooth, round tumors called trichoepitheliomas, which arise from hair follicles. (medlineplus.gov)
  • while previously thought to derive from sweat glands, they are now generally believed to begin in hair follicles. (medlineplus.gov)
  • The pituitary gland produces thyroid stimulating hormone (TSH) that goes into the blood stream to activate thyroid cells, which then secrete T3 and T4 into the peripheral tissues. (cdc.gov)
  • Overproduction of prolactin by the pituitary gland can cause galactorrhea (excessive or abnormal lactation) and amenorrhea (absence of menstruation). (rnpedia.com)
  • Solitary fibrous tumor (SFT) has been increasingly reported in various anatomic sites. (cn1699.cn)
  • The currently accepted nomenclature is solitary fibrous tumor. (medscape.com)
  • Neoplasms that arise from endocrine tissue may also secrete hormones, resulting in excessive levels of these hormones in the body and potentially a wide variety of symptoms. (rarediseases.org)
  • nonfunctioning neoplasms may produce hormones, but no systemic symptoms. (rarediseases.org)
  • Nonfunctioning neuroendocrine neoplasms can still cause symptoms relating to tumor size and location such as obstruction or internal bleeding. (rarediseases.org)
  • Tumors arising from the upper aero-digestive tract, often simply referred to as Head and Neck tumors, may present with hard painless neck lumps, or with a variety of symptoms related to the site of origin, eg throat pain, difficulty swallowing and voice change for throat or voice box cancer, or a non-healing tongue ulcer or tooth socket for cancers of the oral cavity. (thyroidheadnecksurgery.com)
  • Patients with lymphoma may be completely asymptomatic except for the neck lump, or may have systemic symptoms like fever, night sweats or joint pain. (thyroidheadnecksurgery.com)
  • The symptoms of adrenal Pheochromocytoma include headaches, palpitation, profuse sweating, glucose intolerance , heat sensitivity and decreased blood pressure. (targetwoman.com)
  • The treatment for tufted angioma is multimodal and individualized, depending on the extent of tumor invasion, tumor size, presence of symptoms, and presence or absence of Kasabach-Merritt syndrome . (medscape.com)
  • The pancreas is a gland located between the stomach, spleen, duodenum and colon transversum. (rarediseases.org)
  • Pancreatic neuroendocrine neoplasms (pNENs) are an increasingly common group of malignancies that arise within the endocrine tissue of the pancreas. (rarediseases.org)
  • Any tumor of the pancreas interferes with the functioning of the body in varying degrees. (vsebolezni.com)
  • Usually benign neoplasm in the pancreas for a long time does not manifest itself. (vsebolezni.com)
  • Treatment of tumors of the pancreas only online. (vsebolezni.com)
  • Tumor of head of pancreas leads to impaired patency of the duodenum, the common bile duct. (vsebolezni.com)
  • The tumors mostly appear on the face, especially in the folds in the skin between the nose and lips (nasolabial folds, sometimes called smile lines), but may also occur on the neck, scalp, or trunk. (medlineplus.gov)
  • For tumors to develop, a second mutation or deletion of genetic material involving the other copy of the CYLD gene must occur in certain cells during a person's lifetime. (medlineplus.gov)
  • These tumors occur predominantly on one adrenal gland as an unilateral condition. (targetwoman.com)
  • These tumors occur together with other disorders such as endocrine neoplasia type 2. (targetwoman.com)
  • Various malignant skin tumors have been reported to co-occur with BCC at one site [ 3 ]. (e-acfs.org)
  • There are three types of sweat glands that occur over the skin surface: eccrine, apocrine and apoeccrine. (biomedcentral.com)
  • B-cell lymphoid tumors that occur in association with AIDS. (lookformedical.com)
  • Histologically, a poroma is a well-circumscribed tumor that arises in the lower epidermis and extends into the dermis. (clinicaladvisor.com)
  • ABSTRACT: Multiple primary malignancies (MPMs) refer to the presence of 2 or more histologically distinct malignant tumors in the same individual. (bvsalud.org)
  • The authors concluded: "Our study confirms that most of the secondary neoplasms arising in association with nevus sebaceus are benign. (aad.org)
  • The medical importance of a solitary nevus sebaceus relates to the description of both benign change and, in some cases, malignant neoplastic change. (medscape.com)
  • Nevus sebaceous is a rare benign tumor in children that usually presents with warty patches of hair loss on the scalp. (medscape.com)
  • The development of secondary malignant neoplasms within the nevus sebaceus is rare and occurs almost exclusively in adults. (medscape.com)
  • Jaqueti G, Requena L, Sanchez Yus E. Trichoblastoma is the most common neoplasm developed in nevus sebaceus of Jadassohn: a clinicopathologic study of a series of 155 cases. (medscape.com)
  • The main reason is the accumulation of lipids in the sebaceous gland, which leads to its blockage. (medhelpsis.com)
  • [2] These tumors clinically present in middle-aged to elderly individuals as an asymptomatic, slowly enlarging, red or red-brown, dome-shaped papule or nodule with a wafer-like scale collarette. (statpearls.com)
  • The distinction among these various tumors is important both clinically and epidemiologically. (medscape.com)
  • 1) takes omohyoid, submandibular gland, sensory nerves C2-C5, cervical branch of facial nerve, and ipsilateral thyroid2) same as above + accessory nerve (CN XII), SCM, and internal jugular resection. (brainscape.com)
  • Spiradenomas are benign neoplasms originally thought to arise from sweat glands in the dermal layer of the skin. (medscape.com)
  • Although usually benign, spiradenomas can rarely be malignant or transform to spiradenocarcinoma. (medscape.com)
  • Spiradenomas arise from the hair follicle bulge rather than the eccrine sweat gland, based on an immunohistochemical study of stem cell markers and with CD200. (medscape.com)
  • [ 1 ] All 27 spiradenomas and 30 cylindromas in this study were positive for CD200, whereas other tumors thought to be of eccrine lineage were all negative, suggesting that spiradenomas are not eccrine tumors, but rather are follicular tumors derived from the hair follicle bulge and representing the least differentiated follicular tumors. (medscape.com)
  • A defective tumor suppressor gene is believed to result in the development of spiradenomas. (medscape.com)
  • Spiradenomas seem to be caused by a defective tumor suppressor gene. (medscape.com)
  • Spiradenomas are rare worldwide, with the exact incidence of benign solitary spiradenoma unknown. (medscape.com)
  • Spiradenomas develop in sweat glands. (medlineplus.gov)
  • Additional benign neoplasms such as trichoepithelioma (8), tubular apocrine adenomas (9), sebaceomas (1), and others have been reported within NS. (aad.org)
  • They were first described in 1956 by Kersting and Helwig as a distinct form of sweat gland tumor ,which they called eccrine spiradenoma. (medscape.com)
  • Intraepidermal Eccrine Adenocarcinomas (IEA) are rare malignant tumors derived from the eccrine sweat glands of the skin. (faoj.org)
  • P53 is a tumor suppressor gene that codes for a transcription factor that regulates the expression of other genes and arrests the cell cycle. (doctorlib.info)
  • It is unclear whether clear cell acanthoma represents a benign neoplasm or a reactive inflammatory dermatosis. (statpearls.com)
  • We recently treated an unusual case of pilomatricoma with cystic features in the upper chest of a 9-year-old girl, which manifested as a single solid tumour floating in a serous-filled sac formed by thick fibrous tissue. (bvsalud.org)
  • Moreover, the fibrous nature of the tumor has given rise to various other names, such as pleural fibroma, submesothelial fibroma, and localized fibrous tumor. (medscape.com)
  • With the emergence of many immunomarkers, immunohistochemistry has become a vital ancillary diagnostic tool in dermatopathology and an essential adjunct for the correct identification of skin neoplasms. (edu.au)
  • The complexity of some skin neoplasms makes it imperative that the role of immunohistochemistry in subtyping these conditions is clearly understood. (edu.au)
  • Affected individuals are also at increased risk of developing tumors in tissues other than skin appendages, particularly benign or malignant tumors of the salivary glands. (medlineplus.gov)
  • The loss of CYLD protein in these cells leads to the growth of skin appendage tumors. (medlineplus.gov)
  • It is unclear why mutations in the CYLD gene cause different patterns of skin appendage tumors in each of these conditions, or why the tumors are generally confined to the skin in these disorders. (medlineplus.gov)
  • This paper describes a case of a 71-year-old female who initially went to a dermatologist to assess a scalp skin tumor, which performed an incisional biopsy. (bvsalud.org)
  • Porocarcinoma (PC) is a rare type of skin cancer that typically arises from sweat glands. (e-acfs.org)
  • Most swollen glands or lumps under the skin are not cause for concern. (healthlinkbc.ca)
  • Swollen glands and other lumps under the skin can be caused by many different things, including illness, infection, or another cause. (healthlinkbc.ca)
  • Adnexal tumors of the skin. (markahurt.com)
  • Background: Adnexal skin tumors share many features in common and differentiate along one line. (bvsalud.org)
  • A grease is a benign neoplasm that can grow under the skin, on the mucous membranes and inside the body. (medhelpsis.com)
  • Such sweat glands are distributed over the entire body skin surface, with the greatest density being found on the palms of the hands and soles of the feet [ 1 ]. (biomedcentral.com)
  • Digital examination revealed a huge (5 × 5 × 5 cm), well-defined solid tumor associated with a skin ulcer, which was located over the left posterior region of the buttock adjacent to the anus. (biomedcentral.com)
  • Tracing back her surgical history, this patient had undergone perianal skin tumor excision twice previously, once in 1981 and again in 1992. (biomedcentral.com)
  • 7) It is likely that many tumors called BCCs were probably benign trichoblastomas. (aad.org)
  • As no malignant tumors were seen in children, we believe it is reasonable to delay surgical management until adolescence. (aad.org)
  • Surgical procedures such as laparoscopic adrenalectomy have produced good results in the removal of adrenal tumors. (targetwoman.com)
  • Treatment generally consists of one or multiple approaches, including surgical excision, pulsed-dye laser (for superficial tumors), and several medications and chemotherapy agents. (medscape.com)
  • In summary, molecular alterations in cutaneous neoplasms of the head and neck are often related to UV exposure. (ejmjih.com)
  • The malignant nonfunctional tumors are caused by conditions such as neuroblastoma and lymphoma. (targetwoman.com)
  • B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma. (lookformedical.com)
  • Their molecular footprint often reflects the histologic tumor type, and familiarity with these changes will be increasingly necessary for diagnostic and therapeutic considerations. (ejmjih.com)
  • The term fibroma is inappropriate because the neoplasm exhibits defined histologic features that differ from those of fibromas and may express malignant behavior. (medscape.com)