• Recently, an increasing number of studies have revealed that microRNA-497 (miR-497) levels are decreased in tumors, and that it functions as a tumor suppressor in a number of types of human cancer, including colorectal, gastric, cervical and breast cancers, adrenocortical carcinoma and melanoma ( 12 - 20 ). (spandidos-publications.com)
  • For about 25% of patients with hepatocellular carcinoma whose cancer cannot be treated with surgery or liver transplantation, lenvatinib has proven effective at preventing tumor progression. (ascopost.com)
  • In the new retrospective study, investigators analyzed the genetic profiles of circulating tumor DNA (ctDNA) for 46 patients with hepatocellular carcinoma-16 of whom were treated with lenvatinib and 30 of whom were treated with immunotherapy. (ascopost.com)
  • Background There is strong evidence that portal vein tumor thrombosis (PVTT) is associated with poor survival in patients with hepatocellular carcinoma (HCC). (uni-koeln.de)
  • A rare tumor containing unequivocal elements of both hepatocellular and cholangiocarcinoma that are intimately admixed. (mycancergenome.org)
  • This tumor should be distinguished from separate hepatocellular carcinoma and cholangiocarcinoma arising in the same liver. (mycancergenome.org)
  • Irving, TX, Jan. 15, 2015 - Caris Life Sciences® today announced the presentation of data from two studies in which Caris Molecular Intelligence™, the company's panomic, comprehensive tumor profiling service, yielded insights into the biology of hepatocellular and biliary tract carcinomas, while also identifying potential treatment options for patients living with these tumor types. (carislifesciences.com)
  • In a separate presentation, use of Caris Molecular Intelligence reportedly uncovered distinct targetable biomarkers in biliary tract carcinomas such as extrahepatic cholangiocarcinoma (EHCC), intrahepatic cholangiocarcinoma (IHCC), and gallbladder carcinoma (GBCA), while also suggesting the potential sensitivity of these rare, aggressive tumor types to novel and conventional therapies. (carislifesciences.com)
  • Alternative Biomarkers to Predict Tumor Biology in Hepatocellular Carcinoma. (bvsalud.org)
  • Hepatocellular carcinoma (HCC) is the most frequent primary malignant liver tumor , with more than 800,000 new cases diagnosed each year and with high mortality , ranking fourth in the world in cancer deaths. (bvsalud.org)
  • NCCN clinical practice guidelines in oncology: hepatocellular carcinoma. (medlineplus.gov)
  • Drug resistance in hepatocellular carcinoma is common but has not been well understood," explained senior study author David Hsieh, MD , Assistant Professor of Internal Medicine in the Division of Hematology and Oncology at the University of Texas Southwestern Medical Center. (ascopost.com)
  • ABSTRACT The study's objective was to evaluate the clinical significance of sCD40L in HCV- associated hepatocellular carcinoma (HCV-HCC) patients. (who.int)
  • Chronically infected persons are at increased lifetime risk for cirrhosis and hepatocellular carcinoma (HCC) and also serve as the main reservoir for continued HBV transmission. (cdc.gov)
  • Infection with HBV results in a wide spectrum of acute and chronic liver diseases that may lead to cirrhosis and hepatocellular carcinoma. (cdc.gov)
  • Certain benign liver tumors, such as hepatocellular adenoma, may sometimes be associated with coexisting malignant HCC. (wikipedia.org)
  • By examining the ctDNA collected prior to treatment and following cancer progression after treatment, the investigators were able to identify differences in the genetic profiles of hepatocellular carcinoma tumors once they were resistant to treatment. (ascopost.com)
  • Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer in adults and is currently the most common cause of death in people with cirrhosis. (wikipedia.org)
  • Hepatocellular carcinoma is cancer that starts in the liver. (medlineplus.gov)
  • Hepatocellular carcinoma is the most common type of liver cancer. (medlineplus.gov)
  • Hepatocellular carcinoma is not the same as metastatic liver cancer . (medlineplus.gov)
  • In most cases, the cause of hepatocellular liver cancer is long-term damage and scarring of the liver ( cirrhosis ). (medlineplus.gov)
  • The Texas Hepatocellular Carcinoma Consortium was established in 2015 to reduce the burden and mortality of hepatocellular cancer (HCC) in Texas. (bcm.edu)
  • Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of hepatocellular carcinoma. (nature.com)
  • Hepatocellular carcinoma is a type of liver cancer. (healthline.com)
  • Hepatocellular carcinoma (HCC) is the sixth most common cancer in the world and the third most fatal cancer [ 1 ]. (hindawi.com)
  • Liver cancer is the third leading cause of cancer-associated mortality, of which hepatocellular carcinoma (HCC) represents 90% of all primary liver cancers. (wjgnet.com)
  • 1 Hepatocellular carcinoma (HCC) has been the fastest rising cause of cancer-related deaths in the United States, increasing by 2% to 3% annually. (ajmc.com)
  • FORT LEE, N.J., Sept. 19, 2023 (GLOBE NEWSWIRE) -- Elevar Therapeutics, Inc., a majority-owned subsidiary of HLB Co., Ltd. and a fully integrated biopharmaceutical company dedicated to elevating treatment experiences and outcomes for patients who have limited or inadequate therapeutic options, today announced a new partnership with the Benefactors Council of Blue Faery: The Adrienne Wilson Liver Cancer Association , a leading hepatocellular cancer (HCC) advocacy group. (kfor.com)
  • There are over 35,000 new diagnoses of hepatic cancer in the United States per year-most of which involve hepatocellular carcinoma-according to the U.S. Centers for Disease Control and Prevention. (ascopost.com)
  • The investigators next carried out an additional analysis of 227 patients treated for hepatocellular carcinoma at cancer centers across the country. (ascopost.com)
  • Hepatocellular carcinoma (HCC) is a major type of death-causing cancer whose pathological mechanisms are not fully understood. (jcancer.org)
  • Hepatocellular carcinoma (HCC), ranking the fourth of cancer-associated mortality, leads to a threat to increasing life expectancy globally [ 1 ]. (jcancer.org)
  • Cancer due to tumour formation by the hepatic cells of the liver is known as hepatocellular carcinoma (HCC). (ccimindia.org)
  • However, its expression level and functional significance in hepatocellular cancer (HCC) are still disputed. (uni-regensburg.de)
  • Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide, with more than 80 % of cases found in endemic areas of hepatitis B such as Africa or East Asia. (biomedcentral.com)
  • BACKGROUND AND AIM: Hepatocellular carcinoma (HCC) is a frequent cancer. (ox.ac.uk)
  • Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide, and shows an increasing incidence in many Western countries. (medscape.com)
  • Primary Liver Cancer Primary liver cancer is usually hepatocellular carcinoma (HCC). (msdmanuals.com)
  • Hepatitis and hepatocellular carcinoma : novel approaches : joint conference of the National Health Research Institutes (NHRI) and American Association for Cancer Research (AACR) in conjuction with 4th TCOG annual meeting. (who.int)
  • Infection with human papillomavirus increases the probability of developing carcinoma of the cervix, which is the second leading cause of cancer- related mortality in females worldwide, killing some 240 000 women per year.1 Making a correct diagnosis of a sexually transmitted infection is essential for the provision of appropriate and effective treatment. (who.int)
  • Updated efficacy and safety data from IMbrave150: atezolizumab plus bevacizumab vs. sorafenib for unresectable hepatocellular carcinoma. (nature.com)
  • Atezolizumab plus bevacizumab in unresectable hepatocellular carcinoma. (nature.com)
  • Tremelimumab plus durvalumab in unresectable hepatocellular carcinoma. (nature.com)
  • On October 21, 2022, the FDA approved tremelimumab (Imjudo) in combination with durvalumab for adult patients with unresectable hepatocellular carcinoma. (aacrjournals.org)
  • The approval was based on the results from the HIMALAYA study, in which patients with unresectable hepatocellular carcinoma who were naïve to previous systemic treatment were randomly assigned to receive one of three study arms: tremelimumab in combination with durvalumab ( n = 393), durvalumab ( n = 389), or sorafenib ( n = 389). (aacrjournals.org)
  • Craig A, von Felden J, Garcia-Lezana T, Sarcognato S and Villanueva A: Tumour evolution in hepatocellular carcinoma. (spandidos-publications.com)
  • The aim of this retrospective multicentric study was to compare the tumour response rates of Balloon-occluded Transarterial Chemoembolisation (B-TACE) to non-B-TACE using propensity score matching (PSM) in patients with hepatocellular carcinoma and to investigate the clinical benefit, such as lower rates of TACE re-intervention achieved using B-TACE. (springer.com)
  • The findings of selective celiac and/or hepatic arteriography in total 69 cases of confirmed hepatocellular carcinoma, with clinical and laboratory findings, were analyzed. (osti.gov)
  • In part based on the new findings, the investigators concluded that the University of Texas Southwestern Medical Center now routinely analyzes for genetic mutations present in patients with hepatocellular carcinomas-a practice not conducted for hepatic cancers at most hospitals. (ascopost.com)
  • Hepatitis B (HBV), the leading cause of hepatocellular carcinoma (HCC) worldwide, disproportionately affects minorities in the USA. (physiciansweekly.com)
  • citation needed] Young adults afflicted by the rare fibrolamellar variant of hepatocellular carcinoma may have none of the typical risk factors, such as cirrhosis and hepatitis. (wikipedia.org)
  • Knowledge and Perceptions of Hepatitis B and Hepatocellular Carcinoma Screening Guidelines Among Trainees: A Tale of Three Centers. (physiciansweekly.com)
  • Hepatocellular carcinoma (HCC) usually affects patients aged 50-70 years but earlier onset (25-40 years) may occur in hepatitis B endemic areas. (biomedcentral.com)
  • Hepatocellular carcinoma (HCC) usually occurs in patients with cirrhosis and is common in areas where infection with hepatitis B and C viruses is prevalent. (msdmanuals.com)
  • Preventing hepatitis B in people in close contact with hepatocellular carcinoma patients. (cdc.gov)
  • Surveillance for hepatocellular carcinoma (HCC) in patients with cirrhosis is recommended in clinical guidelines. (medscape.com)
  • Hepatocellular carcinoma (HCC) is primarily a malignancy of the liver, advancing from a damaged, cirrhotic liver to HCC. (wjgnet.com)
  • Hepatocellular carcinoma (HCC) is a primary malignancy of the liver and occurs predominantly in patients with underlying chronic liver disease and cirrhosis. (medscape.com)
  • Anti-androgen flutamide suppresses hepatocellular carcinoma cell proliferation via the aryl hydrocarbon receptor mediated induction of transforming growth factor-β1. (oregonstate.edu)
  • For patients with hepatocellular and biliary tract carcinomas, the limitations of currently available treatment options underscore a great need to identify new therapies," commented Sandeep K. Reddy, M.D., chief medical officer at Caris Life Sciences, and a co-investigator in each of the two studies. (carislifesciences.com)
  • Emerging data indicate that the mortality rate of hepatocellular carcinoma (HCC) associated with cirrhosis is rising in some developed countries, whereas mortality from non-HCC complications of cirrhosis is decreasing or is stable. (nih.gov)
  • Hepatocellular carcinoma (HCC) has become the leading cause of deaths that are caused by all cancers worldwide [1] and the incidence and mortality of HCC are increasing at a faster pace than other cancers, which trend will continue through at least 2030 in United States [2]. (researchsquare.com)
  • These findings can potentially guide future clinical trials on how to prevent and treat lenvatinib resistance in hepatocellular carcinoma as well as other cancers," he added. (ascopost.com)
  • In a presentation at the 2015 Gastrointestinal Cancers Symposium in San Francisco, Calif., the researchers reported that Caris Molecular Intelligence revealed the molecular heterogeneity of hepatocellular carcinoma (HCC) and facilitated identification of potential therapies targeting molecular subtypes of this disease, for which treatment options have heretofore been extremely limited. (carislifesciences.com)
  • Although the molecular mechanisms that regulate autophagy are not fully understood, recent work indicates that dysfunctional/impaired autophagic functions are associated with the development and progression of nonalcoholic fatty liver disease (NAFLD), alcoholic fatty liver disease (AFLD), and hepatocellular carcinoma (HCC). (hindawi.com)
  • Hou G, Lu Z, Wang Z, Yang X. The Mitochondrial Protein C1QBP Promotes Hepatocellular Carcinoma Progression by Enhancing Cell Survival, Migration and Invasion. (jcancer.org)
  • Therefore, research on hepatocellular transformations in initiation and development of HCC and identifying effective biomarkers for novel therapeutic option are still emergency challenges. (researchsquare.com)
  • In male and female F344/DuCrj rats, drinking water containing quinoline increased the incidences of haemangiosarcoma (in various organs), and hepatocellular adenoma and carcinoma. (cdc.gov)
  • Sorafenib in advanced hepatocellular carcinoma. (nature.com)
  • Nivolumab versus sorafenib in advanced hepatocellular carcinoma (CheckMate 459): a randomised, multicentre, open-label, phase 3 trial. (nature.com)
  • SORAMIC is a previously published randomised controlled trial assessing survival in patients with advanced hepatocellular carcinoma who received sorafenib with or without selective internal radiation therapy (SIRT). (cun.es)
  • Our analysis revealed a number of genes previously associated with hepatocellular carcinoma and uncovered their association network in the blood. (frontiersin.org)
  • A genetic marker involving the EGFR and ERBB2 genes may be predictive of which patients with hepatocellular carcinoma are most likely to develop resistance to lenvatinib, according to a study published by Lim et al in Gastroenterology . (ascopost.com)
  • SIRT frequently has a negative, often subclinical, effect on liver function in patients with hepatocellular carcinoma, which may impair prognosis after treatment. (cun.es)
  • Without immunohistological analysis, it is difficult to distinguish this HCC variant from clear cell carcinoma or metastases of renal cell carcinoma. (karger.com)
  • Additionally, hepatocellular carcinoma incidence was increased in male mice. (cdc.gov)
  • Thirdly, it helps to prevent serious complications such as tubal infertility, carcinoma of the cervix and maternal death. (who.int)
  • When patients present with hepatocelluar carcinoma (HCC) at the symptomatic stage, the disease is rapidly fatal, with a mean survival time of less than 4 months (1). (cdc.gov)
  • Immune-checkpoint inhibitors (ICIs) are now widely used for the treatment of patients with advanced-stage hepatocellular carcinoma (HCC). (nature.com)
  • Fujiwara N, Friedman S, Goossens N and Hoshida Y: Risk factors and prevention of hepatocellular carcinoma in the era of precision medicine. (spandidos-publications.com)
  • Factors affecting screening for hepatocellular carcinoma. (ox.ac.uk)
  • The authors concluded that hepatectomy is beneficial in patients with three or fewer hepatocellular carcinomas and either no or Child-Pugh class A cirrhosis, with the long-term results being comparable to those in patients who underwent a resection of a single HCC. (mdedge.com)
  • A suspected contributor to this increased risk is circulating insulin concentration such that diabetics with poor insulin control or on treatments that elevate their insulin output (both states that contribute to a higher circulating insulin concentration) show far greater risk of hepatocellular carcinoma than diabetics on treatments that reduce circulating insulin concentration. (wikipedia.org)
  • EudraCT 2009-012576-27, NCT01126645 LAY SUMMARY: This study of treatments in patients with hepatocellular carcinoma found that selective internal radiation therapy (SIRT) has an adverse effect on liver function that may affect patient outcomes. (cun.es)
  • Transarterial chemoembolization with drug-eluting microspheres (DEM-TACE) is recommended for patients with BCLC stage B hepatocellular carcinoma (HCC) and stage 0-A unsuitable for curative treatments (i.e. surgery or ablation). (terumo-europe.com)
  • 1985. "Angiographic findings of hepatocellular carcinoma. (osti.gov)
  • The risk of hepatocellular carcinoma in type 2 diabetics is greater (from 2.5 to 7.1 times the nondiabetic risk) depending on the duration of diabetes and treatment protocol. (wikipedia.org)
  • Who's at risk for hepatocellular carcinoma? (healthline.com)
  • Low or high level of circulating insulin is also a risk factor for developing hepatocellular carcinoma. (ccimindia.org)
  • The Liver Imaging Reporting and Data System (LI-RADS) categorizes observations from imaging analyses of high-risk patients based on the level of suspicion for hepatocellular carcinoma (HCC) and overall malignancy. (escholarship.org)
  • The failure rate for local disease control was 23%, and was 14% if patients with recurrent hepatocellular carcinoma were excluded. (hkmj.org)
  • Llovet J, Montal R, Sia D and Finn R: Molecular therapies and precision medicine for hepatocellular carcinoma. (spandidos-publications.com)
  • We investigated the AhR-dependent mechanism of action of flutamide in human hepatocellular carcinoma cells and identified that transforming growth factor-β1 (TGF-β1) is induced by flutamide in an AhR-dependent manner. (oregonstate.edu)
  • Coloured scanning electron micrograph (SEM) of two hepatocellular carcinoma (HCC) cells, showing the numerous filopodia (hair-like projections) covering their surface. (lu.se)
  • In this article, we delve deeper into hepatocellular carcinoma. (healthline.com)