- This system allows the investigators to explore the functional properties of individual viral genes of VHSV in detail. (wikipedia.org)
- In the aquaculture environment, this technique has been successfully used to detect, among other pathogens, viral hemorrhagic septicemia virus (VHSV), infectious hematopoietic necrosis virus (IHNV), salmon alphavirus (SAV), Piscirickettsia salmonis , Renibacterium salmoninarum , infectious salmon anemia virus (ISAV), and infectious pancreatic necrosis virus (IPNV). (thefishsite.com)
- Current research in my laboratory has focused on two fish rhabdoviruses - infectious hematopoietic necrosis virus (IHNV) and viral hemorrhagic septicemia virus (VHSV), which are members of the genus Novirhabdovirus of the Rhabdoviridae family. (usmd.edu)
- We established the reverse genetics systems for both IHNV and VHSV whereby infectious rhabdovirus can be recovered entirely from cDNA clones. (usmd.edu)
- Viral hemorrhagic septicemia virus (VHSV), a fish rhabdovirus belonging to the Novirhabdovirus genus, causes severe disease and mortality in many marine and freshwater fish species worldwide. (biomedcentral.com)
- Furthermore, viral RNA fold change and viral titers were lower in animals from the poly I:C + VHSV groups than in the controls. (biomedcentral.com)
- Viral Haemorrhagic Septicaemia Virus (VHSV) is the causal agent of the viral haemorrhagic septicaemia (VHS), an important disease affecting farmed salmonid species. (biomedcentral.com)
- Principles of selective inactivation of viral genome. (fsu.ua)
- In the case of targeting viral RNA, specifically for the diagnosis of the ISA virus in infected tissues of fish, the use of the elongation factor 1 alpha (ELF1α) has been demonstrated to be a reliable reference RNA-expressed control because of its stability and constant expression in Salmo salar organs, in both the presence and the absence of the ISA virus. (thefishsite.com)
- Effect of the Viral Hemorrhagic Septicemia Virus Nonvirion Protein on Translation via PERK-eIF2α Pathway. (usmd.edu)
- Even though it has been demonstrated that the NV gene is not necessary for viral replication, it is highly essential for viral pathogenesis. (wikipedia.org)
- My laboratory is studying the molecular biology of economically important fish viruses and focuses on viral pathogenesis and development of novel vaccines. (usmd.edu)
- Using the reverse genetics approach, we are investigating the function of viral proteins in virulence, host adaptation, pathogenesis, and creating attenuated viruses with vaccine potential against other fish pathogens. (usmd.edu)
- A new role of NV protein has been discovered and demonstrated that it inhibits apoptosis at the early stage of viral infection. (wikipedia.org)
- NNV causes viral encephalopathy and retinopathy in more than 30 species of marine warm-water and cold-water fish, whereas IPNV causes pancreatic necrosis disease in salmon and trout species. (usmd.edu)
- To analyze the array of special literature and to summarize the information obtained regarding antiviral vaccines in aquaculture for the prevention of the most common viral diseases of fish. (fsu.ua)
- Update on viral vaccines for fish. (fsu.ua)
- In nature, fish are exposed to a wide variety of microorganisms of bacterial, viral or fungal origins, many of which are capable of causing disease. (thefishsite.com)
- Reverse genetics is a powerful tool to study and characterize the previously unknown viral genes. (wikipedia.org)
- The viral cause of the disease was discovered in 1963 by M. H. Jenson. (wikipedia.org)
- This note for guidance is intended to provide general guidance on the type of data which should be included i n applications for marketing authorisations for bacterial and viral vaccines intended for administration to fish. (nih.gov)
- Bacterial and Viral Vaccines for Veterinary Use are made. (nih.gov)
- Prophylactic vaccines can inhibit viral migration and persistence. (bvsalud.org)
- In sera from 20 rainbow trout surviving IHN, antibodies to IHNV were detected in 9 fish by PNT, in 12 fish by IF, and in 9 fish by ELISA. (usgs.gov)
- Even though it has been demonstrated that the NV gene is not necessary for viral replication, it is highly essential for viral pathogenesis. (wikipedia.org)
- The successful replication of a viral agent in a host is a complex process which consists of a number of interactions, most of them related to the coevolution of pathogen and host. (biomedcentral.com)
- Reverse genetics is a powerful tool to study and characterize the previously unknown viral genes. (wikipedia.org)
- A new role of NV protein has been discovered and demonstrated that it inhibits apoptosis at the early stage of viral infection. (wikipedia.org)