• Extracts containing these terpene indole alkaloids (TIAs) can inhibit the formation and destabilize preformed fibrils of amyloid β protein (a pathological marker of Alzheimer's disease), and have been shown to improve the cognitive function of mice with Alzheimer-like symptoms. (biomedcentral.com)
  • 9. Hedhili S, Courdavault V, Giglioli-Guivarc'h N, Gantet P. Regulation of the terpene moiety biosynthesis of Catharanthus roseus terpene indole alkaloids. (jmp.ir)
  • Ibogaine is an indole alkaloid found in the roots of Tabernanthe iboga Apocynaceae family, a rain forest shrub that is native to equatorial Africa. (erowid.org)
  • Ibogaine: A Novel Anti-Addictive Compound A Comprehensive Literature Review By: Jonathan Freedlander Advisor: Carlo DiClemente, Ph.D. University of Maryland, Baltimore County Introduction and History Ibogaine is a naturally occurring indole alkaloid, found in a variety of African shrubs of the Tabernanthe genus (Obach, Pablo, and Mash, 1998). (mindvox.com)
  • Ibogaine is a psychedelic alkaloid found in several species of plants in the Apocynaceae family. (tripsitter.com)
  • Among the indole alkaloids, vinblastine and vincristine are currently used to treat a wide variety of neoplasms and is recommended for treatment of Hodgkin's disease, acute leukemia and choriocarcinoma, which is resistant to other types of therapy. (supercriticalfluids.com)
  • The unique antitumor activities of these indole alkaloids have resulted in a great demand for vinblastine and vincristine as anticancer agents. (supercriticalfluids.com)
  • Leaves and stems yield dimeric alkaloids vincristine and vinblastine. (stuartxchange.org)
  • Vinblastine and vincristine alkaloids are dominantly biosynthesized in the aerial parts of periwinkle, broadly applied for cancer treatment. (jmp.ir)
  • 5. Alam MM, Naeem M, Khan MMA and Uddin M. Vincristine and vinblastine anticancer catharanthus alkaloids: pharmacological applications and strategies for yield improvement. (jmp.ir)
  • 22] Dimeric alkaloids such as vincristine and vinblastine are produced by the coupling the smaller indole alkaloids vindoline and catharanthine. (scientificlib.com)
  • Most TIAs are found in three dicotyledon plant families: Apocynaceae, Rubiaceae and Loganiaceae, and are thought to be part of a plants chemical defense against pests [ 10 ]. (biomedcentral.com)
  • Catharanthus roseus is a perennial species of flowering plant in the family Apocynaceae. (stuartxchange.org)
  • 7. Chen Q, Lu X, Guo X, Guo Q and Li D. Metabolomics characterization of two apocynaceae plants, Catharanthus roseus and Vinca minor, using GC-MS and LC-MS methods in combination. (jmp.ir)
  • Alkaloids are called natural nitrogen-containing compounds of the main nature, formed in plants. (medprep.info)
  • Groups of proteinogenic amines (for example, tyramine) and betaines (stakhidrin, trigonelline, etc.) adjoin the alkaloids, which are considered as transitional compounds from the simplest nitrogen-containing compounds (methylamine, trimethylamines, etc.) to the alkaloids proper. (medprep.info)
  • Many plant species widely explored for antimicrobial compounds fall into the family Apocynaceae. (biomedcentral.com)
  • Since the terpenoid indole alkaloids (TIAS) biosynthesis pathway is adjustable, modification of underlying substrate and enzymes concentration by biotic and abiotic elicitors are important approaches for overproduction of these metabolites. (jmp.ir)
  • Lumusidines A-D, bisindole alkaloids of the macroline-macroline type, and one of the macroline-pleiocarpamine type, villalstonidine F, were isolated from the stem-bark extract of Alstonia macrophylla (Apocynaceae). (afpm.org.my)
  • The alkaloids reserpine, aymaline and some total alkaloid products (for example, raunatin) are used. (medprep.info)
  • isolation of alkaloids from several taxa of plants (ordo Magnoliales, Laurales), esp. (cuni.cz)
  • Explant of an alkaloid producing plant, cultured in vitro , has been found to retain the capacity to synthesis alkaloids identical to that in the intact plant (Yoshimatsu and Shimomura, 1991). (scialert.net)
  • Alkaloids can be found throughout the plant, or they can be formed and accumulated only in one or more specific organs. (medprep.info)
  • The iboga root contains 11 other alkaloids - many of which are thought to be biologically active on their own. (tripsitter.com)
  • The transcriptome data from this study provides an important resource for understanding the formation of major bioactive constituents in the capsule extract from Uncaria , and provides information that may aid in metabolic engineering to increase yields of these important alkaloids. (biomedcentral.com)
  • Plant yields an amorphous alkaloid, vincarosin. (stuartxchange.org)
  • According to world literature, by the end of the past decade, the number of alkaloids isolated from the higher plants of the Earth's flora exceeded 5000. (medprep.info)
  • According to modern concepts, alkaloid-bearing plants make up 10% of the entire world flora. (medprep.info)
  • Usually plants that are phylogenetically close contain alkaloids that are very similar in structure, thus forming a natural group of genera. (medprep.info)
  • The CSIRO in the post war years did a phytochemical survey examining many of Australia's plants for alkaloid content and this has been compiled in a book Plants for Medicines by D.J. Collins, C.C.J. Culvenor, J.A. Lamberton, J.W. Loder and J.R. Price, CSIRO, 1990. (works.org)
  • We here reported the influence of media composition on effective callus induction to facilitate modern approaches of alkaloids production as well as regeneration for the conservation of the threatened genotype. (scialert.net)
  • Therefore, over production of these alkaloids by using the biotechnological approaches is inevitable. (jmp.ir)
  • Mass spectral analysis gave a few characteristic m/z values suggesting the presence of a few known indole alkaloids, while HPLC profiling highlighted the complexity of the extract. (afpm.org.my)
  • This graph shows the total number of publications written about "Secologanin Tryptamine Alkaloids" by people in Harvard Catalyst Profiles by year, and whether "Secologanin Tryptamine Alkaloids" was a major or minor topic of these publication. (harvard.edu)
  • Of natural pharmacologically active substances, alkaloids are the main group from which modern medicine draws the largest number of highly effective drugs. (medprep.info)
  • The major medicinal alkaloids isolated from Uncaria rhynchophylla (gouteng in chinese) capsules are rhynchophylline (RIN) and isorhynchophylline (IRN). (biomedcentral.com)
  • Breeding techniques have produced more than 100 varieties, with improved floral traits, increase tolerance to disease and alkaloid yield. (stuartxchange.org)