• For example, over one-half of patients diagnosed with hematological malignancies have some evidence of malnutrition, and more than a third have impaired physical function. (dana-farber.org)
  • T cell immune protection plays a pivotal role in the treatment of patients with hematological malignancies. (hindawi.com)
  • However, T cell exhaustion might lead to the possibility of immune escape of hematological malignancies. (hindawi.com)
  • Adoptive cell therapy (ACT) with chimeric antigen receptor T (CAR-T) cells can restore the activity of exhausted T cell through reprogramming and is widely used in the treatment of relapsed/refractory (r/r) hematological malignancies. (hindawi.com)
  • However, CAR-T cells can also produce some adverse events after treatment of hematological malignancies, such as cytokine release syndrome (CRS), neurotoxicity, and on-target/off-tumor toxicity, which may cause systemic immune stress inflammation, destruction of the blood-brain barrier, and even normal tissue damage. (hindawi.com)
  • Over the last few decades, the treatment of hematological malignancies has gained tremendous headway, but these diseases still have high morbidity and mortality [ 1 - 3 ]. (hindawi.com)
  • Traditionally, the treatment of hematological malignancies is administrated by chemotherapy, radiotherapy, and stem cell transplantation. (hindawi.com)
  • In recent years, with the increased understanding of the molecular genetic basis of these malignancies, immune-targeted therapy has become a new possibility for the treatment of hematological malignancies. (hindawi.com)
  • It is noted that T cell has great potential for immunotherapy of hematological malignancies. (hindawi.com)
  • In addition, the isolation and storage of umbilical cord blood hematopoietic stem cells have been used to rebuild the immune system for the treatment of hematological malignancies and might be promising for the dynamic equilibrium expansion of functional T cells [ 12 ]. (hindawi.com)
  • OBJECTIVE: To characterize 414 patients with primary SS who developed hematological malignancies and to analyze how the main SS- and lymphoma-related features can modify the presentation patterns and outcomes. (lu.se)
  • Hematological malignancies diagnosed according to the World Health Organization (WHO) classification were retrospectively identified. (lu.se)
  • RESULTS: There were 414 patients (355 women, mean age 57 years) with hematological malignancies (in 43, malignancy preceded at least one year the SS diagnosis). (lu.se)
  • CONCLUSION: In the largest reported study of hematological malignancies complicating primary SS, we confirm the overwhelming predominance of B cell lymphomas, especially MALT, with the salivary glands being the primary site of involvement. (lu.se)
  • Hematological malignancies. (bvsalud.org)
  • The results of a study led by researchers from the IARC Section of Environment and Radiation analysing in utero exposure to low-dose ionizing radiation in the Southern Urals, Russian Federation, and its link to the lifetime risk of haematological malignancies have been published in the British Journal of Cancer . (who.int)
  • Risk data on overall malignancy and site-specific malignancies (lymphoma, melanoma and lung, colorectal, breast, cervical and prostate cancer) were extracted. (nih.gov)
  • The standardized incidence ratios (SIRs) of the overall and site-specific malignancies were estimated and compared with the incidence of cancer in the general population retrieved from the National Cancer Registry. (nature.com)
  • A growing body of evidence has demonstrated the importance of access to high-volume hospitals and providers for optimal management and outcomes related to gynecologic malignancies. (frontiersin.org)
  • The purpose of this paper is to provide a review of site-specific treatment options that involve the targeting of angiogenesis in gynecologic malignancies. (cancernetwork.com)
  • Each year, more than 91,700 new cases of gynecologic malignancies are diagnosed in the United States, and more than 28,000 women lose their lives to gynecologic cancer. (cancernetwork.com)
  • Ovarian cancer (OC) is the leading cause of death among women with gynecologic malignancy. (mdpi.com)
  • Clinical outcomes of pelvic exenteration for gynecologic malignancies. (bvsalud.org)
  • The aim of this study was to analyze morbidity and survival after pelvic exenteration for gynecologic malignancies and evaluate prognostic factors influencing postoperative outcome. (bvsalud.org)
  • Postoperative complications after pelvic exenteration for gynecologic malignancies are common, especially in irradiated patients . (bvsalud.org)
  • During 9 years of follow-up beginning in 1995, the authors documented 157 hematologic malignancies, including 119 cases of lymphoid neoplasms and 36 cases of myeloid neoplasms. (greenmedinfo.com)
  • We conclude that downregulation of MYBL2 activity below levels predicted by classical haploinsufficiency underlies the clonal expansion of hematopoietic progenitors in a large fraction of human myeloid malignancies. (elifesciences.org)
  • Abnormalities in this process lead to a group of diseases known as myeloid malignancies, which include acute myeloid leukaemia-in which the bone marrow produces abnormal white blood cells-and myelodysplastic syndromes, which are caused by too few mature blood cells being produced. (elifesciences.org)
  • This deletion is only ever seen in one of their two copies of the chromosome-suggesting that at least some of these genes are essential for survival-but the identity of the gene(s) that are associated with the increased risk of myeloid malignancies is unknown. (elifesciences.org)
  • Myeloid malignancy patients lacking one copy of this gene showed levels of MYBL2 expression that were less than 50% of those in healthy individuals. (elifesciences.org)
  • used gene silencing techniques to reduce the expression of MYBL2 in mice and showed that this induced symptoms of myeloid malignancies in the animals. (elifesciences.org)
  • In addition to revealing a new tumor suppressor gene and its contribution to myeloid malignancies, the study by Heinrichs et al. (elifesciences.org)
  • Array-based comparative genomic hybridization characterization of cytogenetically polyclonal myeloid malignancies. (lu.se)
  • Two cases of multiple primary malignancies (two or more neoplasms without any relationship between them) are presented in this paper. (banglajol.info)
  • Evidence of frailty is very common in older patients with hematologic malignancy. (dana-farber.org)
  • Dana-Farber's Older Adult Hematologic Malignancy (OHM) Program is a unique research and clinical service that addresses the specialized needs of older patients with blood cancers. (dana-farber.org)
  • Providers who are referring patients for hematologic malignancy consultation can also request that they see one of our embedded geriatricians on the same day, regardless of the patient's age or frailty. (dana-farber.org)
  • Deoxycoformycin(DCF)/Pentostatin is a T-cell cytotoxic drug with previously reported responses in lymphoid malignancies but larger studies are needed. (knowcancer.com)
  • Histologic proof of lymphoid malignancy with an expected complete response rate of less than 20 percent OR have failed at least one prior therapy. (knowcancer.com)
  • Overall responses (OR) of participants with lymphoid malignancies to Deoxycoformycin (DCF)/Pentostatin defined as Complete Response (CR) and Partial Response (PR). (knowcancer.com)
  • We performed a systematic literature review and analysis to quantify the incidence of malignancies in patients with RA and the general population to update previously published data. (nih.gov)
  • However, the incidence of malignancies in systemic vasculitis is relatively unknown. (nature.com)
  • This prospective cohort study aims to investigate the incidence, related factors and prognosis of IgG4-related disease (IgG4-RD) with malignancies in the Chinese cohort. (nature.com)
  • Ten of them developed malignancy after the diagnosis of IgG4-RD, given a standard incidence ratio (SIR) of 2.78 (95%CI 1.33-5.12). (nature.com)
  • We conclude that an increased incidence of malignancy was found in Chinese IgG4-RD cohort. (nature.com)
  • We sought to describe the incidence and clinical characteristics of malignancies in patients with IgG4-RD. Based on these results, significant factors were evaluated to determine whether they were related to malignancy. (nature.com)
  • Liposarcoma , a malignancy of fat cells, is the most common soft tissue sarcoma with an annual incidence of 2.5% cases per million. (drrathresearch.org)
  • Malignancy in cancers is characterized by anaplasia, invasiveness, and metastasis. (wikipedia.org)
  • Peritoneal based malignancies refer to cancers that either originate from the peritoneum or have spread to involve the peritoneal lining. (sgh.com.sg)
  • Malignancies of the soft tissues (6%) and bone (5%) account for more than 10% of cancers diagnosed in children, adolescents, and young adults. (drrathresearch.org)
  • Our aim was to evaluate rate and prognostic factors of mortality due to non-AIDS defining malignancies (NADM) among persons living with HIV (PLWH) from the cohort of the Spanish AIDS Research Network (CoRIS) during 2004-2020. (natap.org)
  • 2 Mortality rates for these malignancies have declined significantly as a result of improvements in supportive care and therapy. (aafp.org)
  • 1. De novo malignancy is one of the leading causes of late mortality after liver transplantation. (cun.es)
  • Cancer mortality in salaried males was near expectation, but lymphohaematopoietic malignancies were significantly elevated (SMR=1.52, 95% CI 1.06 to 2.12). (cdc.gov)
  • Cervical and ovarian carcinogenesis employ different pathways to achieve cellular immortalization, and this has a significant bearing on the evidence supporting the use of anti-angiogenic agents in the two malignancies. (cancernetwork.com)
  • They were observed until the diagnosis of malignancy, death, or end of the observational period, December 2020. (nature.com)
  • Moreover, it is difficult for clinicians to make a diagnosis of IgG4-RD because it can manifest as mass lesions, leading to an occasional misdiagnosis of malignancy. (nature.com)
  • With few exceptions, most SWI/SNF-deficient malignancies pursue a highly aggressive clinical course resulting in widespread disease dissemination either at or soon after diagnosis, ultimately causing patients' death soon after diagnosis, despite the apparently curative treatment intention. (lww.com)
  • Accordingly, when the diagnosis of LEMS is confirmed, perform an extensive search for an underlying malignancy with radiography and computed tomography (CT) of the chest, bronchoscopy, and possibly positron emission tomography (PET) scanning. (medscape.com)
  • A malignant tumor contrasts with a non-cancerous benign tumor in that a malignancy is not self-limited in its growth, is capable of invading into adjacent tissues, and may be capable of spreading to distant tissues. (wikipedia.org)
  • In summary, our data highlight MCT4 /SLC16A3 as a key gene for distinct hallmarks of tumor malignancy in glioma cells. (hindawi.com)
  • We investigated the impact on tumor malignancy in F98 glioma cells using in silico analysis, in vitro cell culture assays, and ex vivo vascular organotypic glioma impact model (VOGIM) [ 35 ] by implanting F98 cells into rat brain slices. (hindawi.com)
  • The modified cells are able to expand more robustly than normal cells, and this dominance induced by downregulation of the tumor suppressor increases the risk of malignancy. (elifesciences.org)
  • If no tumor is found, periodically search again for occult malignancy. (medscape.com)
  • Once signs and symptoms do arise, they are dependent on the location, size and type of malignancy. (wikipedia.org)
  • Primary care physicians should be alert for possible presenting signs and symptoms of childhood malignancy, particularly in patients with Down syndrome or other congenital and familial conditions associated with an increased risk of cancer. (aafp.org)
  • The objectives of this study were to determine the prevalence, distribution, and frequency of malignancy in solitary and multiple thyroid nodules. (thyroidmanager.org)
  • Recent studies using ultrasonographic-guided FNA cytology report a 7-14 % prevalence of thyroid cancer and suggest that neither nodule size nor number of nodules influences the likelihood of malignancy. (thyroidmanager.org)
  • Data regarding demographics, clinical features, treatment and prognosis of IgG4-RD patients complicating malignancies were collected and compared to those of age- and sex-matched controls. (nature.com)
  • Recently the Endocrine Society published a new clinical practice guideline entitled, "Treatment of Hypercalcemia of Malignancy in Adults: An Endocrine Society Clinical Practice Guideline. (endocrine.org)
  • Moreover, clinical parameters were also important determinants of malignancy. (thyroidmanager.org)
  • The most common childhood malignancies are acute lymphoblastic leukemia, central nervous system (CNS) tumors and lymphomas. (aafp.org)
  • Patients with RA are at an increased risk of lung and lymphoma malignancies compared with the general population. (nih.gov)
  • 4. The most important risks for posttransplant malignancy are Epstein-Barr virus seronegativity (for lymphoma), sun exposure (for skin cancer), smoking, and increasing age. (cun.es)
  • CHI Memorial Rees Skillern Cancer Institute provides comprehensive care for the treatment of hematologic malignancies including the three most common types - leukemia, lymphoma and multiple myeloma. (memorial.org)
  • 376 (91%) patients had mature B cell malignancy, nearly half MALT lymphoma (n = 197), followed by DLBCL (n = 67), nodal MZL lymphoma (n = 29), CLL/SLL (n = 19) and follicular lymphoma (n = 17). (lu.se)
  • We prospectively analyzed the IgG4-RD patients recruited in Peking Union Medical College Hospital from January 2011 to August 2018 and identified patients diagnosed with IgG4-RD complicating malignancies. (nature.com)
  • Introduction: Patients with head and neck cancer or hematologic malignancies who receive chemotherapy or radiotherapy present oral complications as side effects of the treatment. (bvsalud.org)
  • Medicare conducted an analysis of the scientific evidence related to liver transplantation for patients with malignancies. (cms.gov)
  • Attached is a request for a technology assessment that we need in order to develop a Medicare national coverage determination for liver transplantation for malignancies other than hepatocellular carcinoma. (cms.gov)
  • Currently, Medicare national coverage policy for liver transplantation excludes coverage for all malignancies. (cms.gov)
  • HCFA has determined that it does not possess sufficient internal expertise to fully and fairly review liver transplantation for these other malignancies, and that additional resources are required to facilitate this process. (cms.gov)
  • Quantifying differences in malignancy rates between non-biologic and biologic DMARD-treated patients with RA may further highlight which malignancies may be related to treatment rather than to the underlying disease. (nih.gov)
  • An individual with peritoneal based malignancies should be assessed by a multi-disciplinary team of specialists to determine which modality of treatment is best suited for them. (sgh.com.sg)
  • Kaplan-Meier plots of time to first confirmed study-emergent primary malignancy were similar for the 2 treatment cohorts. (rti.org)
  • That's why CHI Memorial implemented the Code Leukemia protocol as part of the organization's growing hematologic malignancies program. (memorial.org)
  • Infectious diseases play a role in the development of malignancy, with agents of infectious disease being able to produce a multitude of malignant cells. (wikipedia.org)
  • Traditional risk factors of developing malignancy include smoking, sun exposure and, having a history of cancer in the family. (wikipedia.org)
  • Other risk factors include developing post-transplant malignancy which occurs subsequent to solid organ transplantations. (wikipedia.org)
  • It is also important to know the risk factors and prognosis for IgG4-RD patients harboring malignancies. (nature.com)
  • Cox proportional hazards modeling, adjusting for confounders and risk factors, resulted in a hazard ratio (omalizumab vs nonomalizumab) of 1.09 (95% CI, 0.87-1.38) for all malignancies and 1.15 (95% CI, 0.83-1.59) for all malignancies excluding NMSC. (rti.org)
  • Although cancer can develop in children of any age, certain malignancies have a predilection for specific age groups. (aafp.org)
  • In cases where a biopsy is not possible or if it is suspected that the fluid build-up (called ascites) that is characteristic of peritoneal based malignancies, is due to other causes, a doctor may remove fluid from the abdomen so that it can be examined under microscope to indicate which type of cancer is present. (sgh.com.sg)
  • Male breast cancer is a rare and understudied malignancy when compared with female breast cancer, with conflicting literature on survival outcomes in men and women. (ascopost.com)
  • The risks of other frequent malignancies, such as prostate and breast cancer, do not seem to be increased. (cun.es)
  • NADM deaths were all deaths due to cancer, except those due to AIDS defining malignancies such as Kaposi sarcoma, certain types of non-Hodgkin lymphomas and cervical cancer. (natap.org)
  • This study aimed to evaluate the relative risk of malignancy in patients with Takayasu's arteritis compared to that in the general population. (nature.com)
  • An increased risk of malignancy was observed in patients with Takayasu's arteritis compared to that in the general population in this large-scale nationwide population study of Korean health insurance data. (nature.com)
  • However, one study from Japan reported no significant increase in the risk of malignancy 8 . (nature.com)
  • The present study focused on the association between IgG4-RD and malignancies. (nature.com)
  • Green tea consumption and hematologic malignancies in Japan: the Ohsaki study. (greenmedinfo.com)
  • The authors used data from the Ohsaki National Health Insurance Cohort Study in Japan to evaluate the association between green tea consumption and the risk of hematologic malignancies. (greenmedinfo.com)
  • The present study evaluated one or more thyroid nodules (>10 mm) evaluated by US-FNA cytology, and reported that the risk of malignancy was similar in a given patient whether single or multiple nodules are present. (thyroidmanager.org)
  • Malignancy rates for findings undergoing image-guided breast biopsy vary by the method of detection, according to research to be presented in this session. (auntminnie.com)
  • In his talk, Alan Zhu from the Mayo Clinic Alix School of Medicine in Scottsdale, AZ, will present results from his team's research, which found lower rates of malignancy with findings on common breast imaging modalities. (auntminnie.com)
  • Zhu and colleagues wanted to compare malignancy rates for findings undergoing image-guided breast biopsy, exploring several methods of detection. (auntminnie.com)
  • However, there are several methods in this area, which may have variable rates of malignancy. (auntminnie.com)
  • In conclusion, green tea consumption was associated with a lower risk of hematologic malignancies. (greenmedinfo.com)
  • Predefined inclusion criteria identified the relevant observational studies published between 2008 and 2014 that provided estimates of relative risk of malignancy in patients with RA compared with the general population. (nih.gov)
  • Projects of the TRR 81 investigate the role of chromatin in the context of cellular differentiation and malignancies at the Philipps-University of Marburg, the Justus-Liebig-University of Giessen, the Erasmus Medical Centre in Rotterdam, the Max Planck Institute for Heart and Lung Research in Bad Nauheim, the Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg, and the Georg-August-University Göttingen. (uni-marburg.de)
  • The second case (65 years) was a female with synchronous dual malignancy of lung and urinary bladder diagnosed within a very short period of time. (banglajol.info)
  • Inflammation can also play a role in triggering malignancy as it can promote stages of tumour formation. (wikipedia.org)
  • Surgical excision is possible and could be curative provided the tumour is resectable in case of primary duodenal malignancy. (sages.org)
  • British Library EThOS: Isoenzymes as markers for malignancy in serious effusions. (bl.uk)
  • Multivariate logistic analysis indicated that autoimmune pancreatitis (OR = 6.230, 95%CI 1.559-24.907, p = 0.010) was positively associated with malignancy, whereas eosinophilia (OR = 0.094, 95%CI 0.010-0.883, p = 0.039) was negatively related with malignancies. (nature.com)
  • Autoimmune pancreatitis is a potential risk factor, whereas eosinophilia is a possible protective factor for complicating malignancies. (nature.com)
  • Patients younger than 50 years without history of long-term smoking have a low risk of associated malignancy, especially if evidence of coexisting autoimmune disease is present. (medscape.com)
  • The remaining bone malignancies in children and adolescents are Ewing sarcomas. (drrathresearch.org)
  • The team also found higher malignancy rates with other imaging modalities and symptomatic detection. (auntminnie.com)
  • Crude malignancy rates were similar in the omalizumab and nonomalizumab cohorts, with a rate ratio of 0.84 (95% CI, 0.62-1.13) for all malignancies and 0.98 (95% CI, 0.71-1.36) for all malignancies excluding NMSC. (rti.org)
  • The multivariate-adjusted hazard ratio of hematologic malignancies for 5 cups/day or more compared with less than 1 cup/day of green tea was 0.58 (95% confidence interval: 0.37, 0.89). (greenmedinfo.com)
  • These different genes produce pheochromocytomas with different ages of onset, secretory profiles, locations, and potential for malignancy. (medscape.com)