• Hereditary paraganglioma-pheochromocytoma - an inherited condition causing different types of tumors that make adrenaline and other hormones. (medlineplus.gov)
  • These neuroendocrine tumors can be similar to pheochromocytomas but form elsewhere in the body. (uchicagomedicine.org)
  • Although pheochromocytomas have classically been associated with 3 syndromes-von Hippel-Lindau (VHL) syndrome, multiple endocrine neoplasia type 2 (MEN 2), and neurofibromatosis type 1 (NF1)-there are now 10 genes that have been identified as sites of mutations leading to these tumors. (medscape.com)
  • When such tumors arise outside of the adrenal gland, they are termed extra-adrenal pheochromocytomas, or paragangliomas. (medscape.com)
  • More recent data have shown that these values are not as specific for adenoma as previously believed, since other adrenal tumors such as pheochromocytoma, hypervascular metastases, and ACC also can meet these washout thresholds. (ctisus.com)
  • Retroperitoneal paragangliomas are cousin tumors of pheochromocytomas, but can arise anywhere in the abdominal cavity (as opposed to only in the adrenal gland). (adrenal.com)
  • It is fully dedicated to supporting research into adrenal tumors by facilitating access to high quality human biological resources (fluids, DNA, cells and/or tissues) and associated bioclinical data from patients with adrenocortical tumors, pheochromocytomas or paragangliomas. (wildapricot.org)
  • Malignant adrenal masses, primary adrenocortical carcinoma, retroperitoneal teratomas and mesenchymal tumors were considered in the differential diagnosis. (jurolsurgery.org)
  • All imaging findings were suggestive of adrenal malignant tumors, primarily adrenocortical carcinoma, secondarily teratomas or mesenchymal tumors. (jurolsurgery.org)
  • Conclusion: We described our step-by-step technique for RA, which can be safely performed even in case of high challenging settings as malignant tumors, pheochromocytoma, and large masses. (bvsalud.org)
  • Surprisingly, following adrenocortical adenoma and pheochromocytoma, the third most common histological entity was metastasis of different extra-adrenal primary tumors to the adrenal gland. (unibe.ch)
  • Background: Molecular classification is important for diagnosis and prognosis of adrenocortical tumors (ACT). (endocrine-abstracts.org)
  • Introduction: Primary bilateral macronodular adrenal hyperplasia (PBMAH) are benign adrenocortical disease responsible for benign tumors and cortisol autonomous secretion. (endocrine-abstracts.org)
  • Dr. Soe is an academic endocrinologist who cares for patients with general endocrine disorders, and endocrine neoplasia (tumors of endocrine glands) including thyroid cancers, pheochromocytoma/paraganglioma and other adrenal tumors. (ucsf.edu)
  • Multiple endocrine neoplasia type 1 is a rare genetic syndrome, characterized by the co-occurrence, in the same individual or in related individuals of the same family, of hyperparathyroidism, duodenopancraetic neuroendocrine tumors, pituitary adenomas, adrenocortical tumors, and neuroendocrine tumors (carcinoids) in the thymus, the bronchi, or the stomach. (nih.gov)
  • Sharma S, Fishbein L. Diagnosis and Management of Pheochromocytomas and Paragangliomas: A Guide for the Clinician. (ucdenver.edu)
  • Isocitrate dehydrogenase mutations are rare in pheochromocytomas and paragangliomas. (cdc.gov)
  • Pheochromocytomas are a type of neuroendocrine tumor . (uchicagomedicine.org)
  • A pheochromocytoma (see the image below) is a rare, catecholamine-secreting tumor derived from chromaffin cells. (medscape.com)
  • The term pheochromocytoma (in Greek, phios means dusky, chroma means color, and cytoma means tumor) refers to the color the tumor cells acquire when stained with chromium salts. (medscape.com)
  • Because of its nonenhanced CT attenuation of less than or equal to 10 HU, a lipid-rich adrenal adenoma may be mimicked by a benign adrenal cyst, or it may be mimicked by a tumor with central cystic and/or necrotic change such as ACC, pheochromocytoma, or metastasis. (ctisus.com)
  • Adrenal adenoma is the most common benign adrenal tumor that arises from the cortex, whereas adrenocortical carcinoma (ACC) is a rare malignant tumor of the cortex. (ctisus.com)
  • Pheochromocytoma is a rare neuroendocrine tumor of the adrenal medulla. (ctisus.com)
  • Difficulties encountered were overhanging nature of tumor, close proximity to renal vessels, desmoplastic reaction in pheochromocytoma and intact specimen retrieval. (sages.org)
  • In a review of 551 cases of adrenocortical carcinoma, mitotane induced a tumor response in 35% of patients. (medscape.com)
  • Adrenocortical carcinoma (ACC) is a rare malignant tumor with an incidence rate of approximately 0.7/million to 2.0/million in the population [ 1 ]. (aging-us.com)
  • A pheochromocytoma (see the image below) is a rare, catecholamine-secreting tumor that may precipitate life-threatening hypertension. (medscape.com)
  • Removed tissue after an open, old-fashioned reoperation for pheochromocytoma tumor spilled throughout the abdomen (called "pheochromocytomatosis") at the initial operation 15 years prior at an outside institution. (adrenal.com)
  • In this paper, we report imaging findings of an adrenal tumor containing a pseudocyst and a myelolipoma which was confused with adrenocortical carcinoma. (jurolsurgery.org)
  • Background: Adrenocortical cancer (ACC) is an aggressive tumor with heterogeneous prognosis. (endocrine-abstracts.org)
  • Author Correction: Single-nuclei and bulk-tissue gene-expression analysis of pheochromocytoma and paraganglioma links disease subtypes with tumor microenvironment. (ucdenver.edu)
  • Adrenocortical adenoma is a benign tumor that is either functional (hormonally active) or non-functioning (hormonally inactive) and is usually asymptomatic, found via unrelated CT scan. (mdapp.co)
  • In MEN2, calcitonin and carcinoembryonic antigen (CEA) serve as excellent tumor markers for medullary thyroid carcinoma. (nih.gov)
  • Heterogeneous adrenal adenomas may mimic ACC, metastasis, or pheochromocytoma, particularly when they are 4 cm or larger, whereas smaller versions of ACC, metastasis, and pheochromocytoma and those with washout greater than 60% may mimic adenoma. (ctisus.com)
  • One patient (adrenocortical sarcoma) died of metastasis 3 months after surgery. (sages.org)
  • Among them, 3 (11.1%) had adrenocortical carcinoma, 6 (22.2%) secondary metastasis, and 1 (3.7%) malignant pheochromocytoma on final pathological exam. (bvsalud.org)
  • Soe's research interests stay in the arena of radioactive iodine refractory thyroid cancer and identifications for risk factors for metastasis in pheochromocytoma and paraganglioma. (ucsf.edu)
  • [ 9 ] For example, an isolated ipsilateral adrenal metastasis in a patient with resectable, primary, non-small cell lung carcinoma is treated as localized disease. (medscape.com)
  • His Mutation research incorporates elements of Hepatocellular carcinoma, microRNA, Thyroid and DNA sequencing. (research.com)
  • Washout measurements may have significantly reduced specificity in the case of renal or hepatocellular carcinoma. (mdapp.co)
  • Bleeding was the cause of conversion in three patients of large pheochromocytomas (size 8 cm), of which two patients were pregnant, technical difficulty in one patient of paraganglioma in the aorta caval window and local invasion in the patient of sarcoma. (sages.org)
  • The goal of this clinical research study is to learn if mitotane alone or in combination with cisplatin and etoposide can help to control adrenocortical carcinoma (ACC) in patients who are at a high risk of having the disease return after surgery. (mdanderson.org)
  • The aim of this study is to determine the frequency of cortisol dysregulation before and after pheochromocytoma surgery.MethodsSingle center retrospective study of consecutive pheochromocytoma patients investigated in the Endocrinology department of Cochin Hospital before and after surgery from 200. (endocrine-abstracts.org)
  • Genomic and sequence variants of protein kinase A regulatory subunit type 1beta (PRKAR1B) in patients with adrenocortical disease and Cushing syndrome. (ukw.de)
  • Routine Glucose Monitoring in Postoperative Pheochromocytoma Patients: Yes or No? (nshealth.ca)
  • TMEM127 screening in a large cohort of patients with pheochromocytoma and/or paraganglioma. (cdc.gov)
  • This most commonly occurs in the setting of a pheochromocytoma or adrenocortical carcinoma (adrenal cancer). (adrenal.com)
  • His Cancer research study incorporates themes from Cell culture, Gene expression, Gene, Immunology and Adrenocortical carcinoma. (research.com)
  • His biological study spans a wide range of topics, including Thyroid carcinoma, Thyroid and Thyroid cancer. (research.com)
  • Cancer research, Internal medicine, Gene, Somatic cell and Adrenocortical carcinoma are his primary areas of study. (research.com)
  • The concepts of his Cancer research study are interwoven with issues in DNA methylation, Mutation, Phenotype, Pheochromocytoma and microRNA. (research.com)
  • The various areas that Thomas J. Giordano examines in his Cancer research study include Germline mutation, Malignancy, DNA methylation, Germline and Pheochromocytoma. (research.com)
  • Data set for reporting of carcinoma of the adrenal cortex: explanations and recommendations of the guidelines from the International Collaboration on Cancer Reporting. (ukw.de)
  • Molecular screening for a personalized treatment approach in advanced adrenocortical cancer. (cdc.gov)
  • I treat benign and malignant thyroid, parathyroid and adrenal disease, including Graves' disease, thyroid cancer, primary and secondary hyperparathyroidism, nonfunctional and functional adrenal masses, adrenocortical carcinoma and more. (ufl.edu)
  • In most cases they are nonfunctioning, benign adrenocortical adenomas. (empendium.com)
  • However, they need to undergo a careful clinical and biochemical evaluation for adrenal hormone excess (pheochromocytoma, primary aldosteronism, Cushing syndrome, feminization/virilism) and the risk of malignancy. (empendium.com)
  • The major role for surgery in this patient population occurs with primary adrenal hypercorticalism either due to adenomas or to adrenal carcinomas. (medscape.com)
  • A substantial minority of pheochromocytomas (30-45%) have absolute or relative washout characteristics that overlap with those of lipid-poor adenomas. (mdapp.co)
  • Xu F , Guan Y , Ma Y , Xue L , Zhang P , Yang X , Chong T , . Bioinformatic analyses and experimental validation of the role of m6A RNA methylation regulators in progression and prognosis of adrenocortical carcinoma. (aging-us.com)
  • Transcriptome profiles separate benign ACT ( C2 cluster) from carcinomas (ACC) and identify two groups of ACC, C1A ( steroid and proliferation signatures) and C1B ( immune signature), of poor and better prognosis respectively. (endocrine-abstracts.org)
  • Because of excessive catecholamine secretion, pheochromocytomas may precipitate life-threatening hypertension or cardiac arrhythmias. (medscape.com)
  • Preoperative management of pheochromocytoma is aimed at control of the catecholamine secretion and its cardiovascular sequelae. (medscape.com)
  • Multiple endocrine neoplastic type 2 is a rare genetic syndrome, characterized by the familial occurrence of medullary thyroid carcinoma either isolated or associated with pheochromocytoma, primary hyperparathyroidism, or typical features (Marfanoid habitus, mucosal neuromas). (nih.gov)
  • These different genes produce pheochromocytomas with different ages of onset, secretory profiles, locations, and potential for malignancy. (medscape.com)
  • Other features such as mass size, heterogeneity, and clinical context (eg, history of hypervascular malignancy or suspicion for pheochromocytoma) must be taken into account when using washout CT. (ctisus.com)
  • About 30% of pheochromocytomas occur as part of hereditary syndromes. (medscape.com)
  • Colton MD, Tompkins K, O'Donnell E, Aisner D, Lieu CH, Konnick EQ, Fishbein L. Case of Metastatic Pheochromocytoma and Meningiomas in a Patient With Lynch Syndrome. (ucdenver.edu)
  • However, specific histologic features help to differentiate adrenal pheochromocytomas with a potential for biologically aggressive behavior from those that behave in a benign fashion. (medscape.com)