• Using this method, combined with proteomic profiling, we show that PC3 human prostate cancer organoids secrete EVs with previously undefined protein cargo, which substantially differs from EV cargo of 2D cultured cells. (biorxiv.org)
  • Recombinant SEAP (secreted embryonic alkaline phosphatase) protein is a truncated form of human placental alkaline phosphatase that comprises 520 amino acids. (invivogen.com)
  • Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-beta1-secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients. (jci.org)
  • Here, we investigated whether in MS patients oral myelin treatment, containing both myelin basic protein (MBP) and proteolipid protein (PLP), induced antigen specific MBP or PLP reactive T cells that either secreted IL4, TGF-beta1, or alternatively did Th1 type sensitization occur as measured by IFN-gamma secretion. (jci.org)
  • As an alternative, researchers sometimes rely on screening of large-scale libraries for identifying strains which secrete a high amount of protein. (titech.ac.jp)
  • The secreted proteome of M. tuberculosis H37Rv culture filtrate made by Sadamu Nagai, was analysed using two different protein separation methods combined with MALDI-TOF and LC-MS/MS. We showed that this culture filtrate was particularly enriched in terms of secreted proteins compared to what has been reported previously. (uib.no)
  • We show that antibodies against proteins belonging to the antigen 85 complex were the most abundant in the serum of M. tuberculosis infected patients, and that secreted lipoproteins were the most immunogenic proteins in term of high antibody to protein amount ratio were lipoprotein, illustrating the importance of this group of proteins for serodiagnostic development. (uib.no)
  • Human non-pancreatic secreted phospholipase A 2 (hnps PLA 2 ) is a small (14 kDa) secreted protein of considerable biomedical interest. (soton.ac.uk)
  • 2003), Darmin is a novel secreted protein expressed du. (xenbase.org)
  • Darmin is a novel secreted protein expressed during endoderm development in Xenopus. (xenbase.org)
  • Darmin encodes a secreted protein of 56 kDa containing a peptidase M20 domain characteristic of the glutamate carboxypeptidase group of zinc metalloproteases. (xenbase.org)
  • We have previously shown that excretory-secretory product-62 (ES-62), a homologue of phosphorylcholine-containing molecules that are secreted by human parasites and which is active in rodent models of filarial infection, is able to polyclonally activate certain protein tyrosine kinase and mitogen-activating protein kinase signal transduction elements in B lymphocytes. (eurekamag.com)
  • Wnt5a is a secreted protein that activates non-canonical Wnt signaling pathways and is known to regulate normal developmental processes, including proliferation, differentiation, migration, adhesion and polarity. (aacrjournals.org)
  • Antigens Tuberculosis antigens used were early secreted antigen-6 (ESAT-6) and culture filtrate protein-10 (CFP-10) (both from Fitzgerald Industries Intl. Inc., Acton, MA). (fabretp.org)
  • This Human Secreted Frizzled-Related Protein 5 ELISA Kit from Innovative Research is intended for quantitative detection of human SFRP5 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA). (innov-research.com)
  • Expression system for standard: Secreted frizzled-related protein 5 is a protein that in humans is encoded by the SFRP5 gene. (innov-research.com)
  • Processing of the asparagine-linked oligosaccharides of secreted and intracellular forms of the vesicular stomatitis virus G protein: in vivo evidence of Golgi apparatus compartmentalization. (rupress.org)
  • After clinical evaluation a giant GH/TSH-secreting pituitary adenoma was diagnosed. (nih.gov)
  • This undifferentiated, monomorphous GH/TSH-secreting pituitary adenoma represents an entity that is unusual both in its ultrastructural features and clinical manifestations suggesting a cytogenesis from an early, undifferentiated stem cell. (nih.gov)
  • The pattern of secreted secondary metabolites among treatments showed important differences. (apsnet.org)
  • 10 μg lyophilized recombinant human secreted embryonic alkaline phosphatase (SEAP). (invivogen.com)
  • Parathyroid tumors secrete parathyroid hormone (PTH). (msdmanuals.com)
  • The important bacterial pathogen Streptococcus pyogenes secretes IdeS (immunoglobulin G-degrading enzyme of S. pyogenes), a proteinase that cleaves human immunoglobulin G (IgG) antibodies in the hinge region resulting in Fc (fragment crystallizable) and F(ab') 2 (fragment antigen-binding) fragments and protects the bacteria against phagocytic killing. (lu.se)
  • The simple approach combines biosensors and microfluidics to quickly identify mutant strains that secrete large amounts of industrially useful proteins, opening the doors to more applications, like reasonably priced biopharmaceuticals. (titech.ac.jp)
  • However, a critical piece of the puzzle remains underexplored: the sophisticated array of proteins and enzymes these pathogens secrete to breach the plant cell wall - the plant's primary defense shield. (findaphd.com)
  • Note that trans‐Golgi cisternae in lactating mammary cells contain large amounts of casein and other milk proteins and are grossly expanded due to the osmolarity of the secreted fluid. (cellimagelibrary.org)
  • Atât propaganda, cât şi serviciile secrete sunt unanim privite drept nişte „chestii" atotputernice şi misterioase, despre care se vorbeşte mult şi se ştie puţin. (revistaflacara.ro)
  • Teoretic, serviciile secrete sunt menite să adune informaţii şi nu ar avea nici o treabă cu propaganda, care difuzează public informaţii de tot felul pentru a-i influenţa pe oameni. (revistaflacara.ro)
  • Sunt doar câteva dintre nenumăratele societăţi secrete care au existat de-a lungul timpului. (bookiseala.ro)
  • Transferable cell-secreted extracellular matrices enhance osteogenic differentiation. (ca.gov)
  • A polymorphic immune cell (red) glides over two spherical V12Ras-transformed mucus-secreting cells (green, possible tumor precursors) in a live three day old zebrafish embryo. (cellimagelibrary.org)
  • Naturally secreted from the deep sea copepod Gaussia princeps (3) (Figure 1), Gaussia Luciferase (GLuc) was first used in a sensitive analytical assay in 2002 (4) and later commercialized by NEB for expression in mammalian cells. (neb.com)
  • Amniotic epithelial cells were believed to secrete an 'Epidermal Growth Factor (EGF) - like' factor and exact identification was not made. (scielo.org.ar)
  • It is interesting to note that while factor secreted by amniotic epithelial cells resembles EGF and/or FGF-2 in its biological action, known isoforms of them were not detected. (scielo.org.ar)
  • Considering the biological closeness between EGF and FGF-2, results indicate the possibility of a novel isoform of these growth factors secreted by amniotic epithelial cells. (scielo.org.ar)
  • In animals with experimental autoimmune disease, a major mechanism of oral tolerance triggered by oral administration of antigen involves the induction of regulatory T cells that mediate active suppression by secreting the cytokine TGF-beta 1. (jci.org)
  • In contrast, no change in the frequency of MBP or PLP specific IFN-gamma or TT specific TGF-beta1 secreting T cells were observed. (jci.org)
  • These results suggest that the oral administration of antigens generates antigen specific TGF-beta1 secreting Th3 cells of presumed mucosal origin that represent a distinct lineage of T cells. (jci.org)
  • Since antigen-specific TGF-beta1 secreting cells localize to the target organ and then suppress inflammation in the local microenvironment, oral tolerization with self antigens may provide a therapeutic approach for the treatment of cell-mediated autoimmune disease which does not depend upon knowledge of the antigen specificity of the original T cell clone triggering the autoimmune cascade. (jci.org)
  • Gastrin-Secreting Cells" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • Endocrine cells which secrete GASTRIN, a peptide that induces GASTRIC ACID secretion. (umassmed.edu)
  • This graph shows the total number of publications written about "Gastrin-Secreting Cells" by people in this website by year, and whether "Gastrin-Secreting Cells" was a major or minor topic of these publications. (umassmed.edu)
  • Below are the most recent publications written about "Gastrin-Secreting Cells" by people in Profiles. (umassmed.edu)
  • The addition of mediators secreted by adenocarcinoma altered the inflammatory response of the mesothelial cells to sclerosing agents. (medscimonit.com)
  • Cells in the adrenal medulla synthesize and secrete epinephrine and norepinephrine. (clambaronline.com)
  • Generally, sPLA 2 s are secreted from cells and require micromolar to millimolar Ca 2+ to be catalytically competent. (ijbs.com)
  • Intravenous immunoglobulin induces IgG internalization by tolerogenic myeloid dendritic cells that secrete IL-10 and expand Fc-specific regulatory T cells. (bvsalud.org)
  • Britanicii rămân însă cei care, cu luciditate şi cinism, au pus în anii Primului Război Mondial amprenta definitivă a cooperării pe cât de strânse, pe atât de secrete dintre serviciile speciale ale statului şi propagandă, deoarece doar astfel se puteau spune sau insinua nişte lucruri despre inamic pe care politicienii, datorită condiţionărilor morale, etice şi de respectabilitate nu le puteau afirma în public. (revistaflacara.ro)
  • Obtained microbeads allow controlled and sustained secretion of amyloid-β over time and can be used to study the effects of secreted amyloid-β in in vitro and in vivo models. (jove.com)
  • Bacteria have developed different secretion systems that allow them to secrete toxins to the outside of the cell. (ibs.fr)
  • We report intracellular accumulation of a secreted antigen-targeted antibody (SATA) that can be used to characterize disease, guide therapy, and monitor response. (lu.se)
  • Following IgG internalization, these two DC lineages secreted IL-10 and presented processed Fc peptides to Treg. (bvsalud.org)
  • We further demonstrated that S. Typhimurium secretes siderophores in iron-rich media when peroxide is present and that these MacAB-secreted metabolites participate in protection of bacteria against H2O2. (ku.edu)
  • M. ulcerans is unique among mycobacteria in that, as they proliferate, the bacteria secrete a necrotizing toxin that destroys tissue and suppresses the immune system. (who.int)
  • This biofilm has been found to protect the bacteria that secrete the substance from attacks by antimicrobial agents such as antibiotics. (cdc.gov)
  • Exploatând din plin experienţa dobândită în marele război pentru apărarea patriei, serviciile secrete sovietice, cu deosebire KGB, s-au angajat total în acest nou tip de confruntare în care orice tip de lovitură era permisă cu condiţia a avea un sprijin politic pe măsură. (revistaflacara.ro)
  • Although virulence is typically attributed to single pathogenic strains, here we investigated whether effectors secreted by a population of non-virulent strains could function as public goods to enable the emergence of collective virulence. (nature.com)
  • Serum secreted phosphoprotein 1 level is associated with plaque vulnerability in patients with coronary artery disease. (bvsalud.org)
  • IdeS is secreted by all S. pyogenes isolates and cleaves IgG antibodies with a unique degree of specificity and efficiency. (lu.se)
  • On this background we investigated the secreted sub-proteome and membrane subproteome of M. tuberculosis and M. bovis in this study. (uib.no)
  • Aldosterone is a steroid hormone synthesized in and secreted from the outer layer of the adrenal cortex , the zona glomerulosa. (moviecultists.com)
  • Figure 386 from Chapter 15 (Cytoplasmic Inclusions) of 'The Cell, 2nd Ed.' by Don W. Fawcett M.D. Exocytosis in a mucus-secreting cell from the colon. (cellimagelibrary.org)
  • Figure 388 from Chapter 15 (Cytoplasmic Inclusions) of 'The Cell, 2nd Ed.' by Don W. Fawcett M.D. Mucus-secreting cell from a crypt of rabbit colonic mucosa after stimulation in vitro with acetycholi. (cellimagelibrary.org)
  • The secreted luciferases derived from Gaussia princeps , Metridia longa and Cypridina noctiluca do not require cell lysis to measure activity and are significantly "brighter" than firefly and Renilla . (neb.com)
  • Ivanušec A, Šribar J, Križaj I. Secreted Phospholipases A 2 - not just Enzymes: Revisited. (ijbs.com)
  • Secreted phospholipases A 2 (sPLA 2 s) (EC 3.1.1.4) are a structurally related group of low-molecular-mass enzymes (14-18 kDa) that catalyse the hydrolysis of glycerophospholipids (phospholipids hereafter) at their sn -2 position, to produce lysophospholipids and free fatty acids. (ijbs.com)
  • Thus, the terminal nerve endings of the parasympa-thetic system all or virtually all secrete acetylcholine. (clambaronline.com)
  • Weighted gene co-expression network analysis showed that Secreted Phosphoprotein 1 (SPP1) in the turquoise module was highly correlated with both the gene module and the clinical traits. (bvsalud.org)
  • The circadian clock in the suprachiasmatic nucleus (SCN) drives daily locomotor activity rhythms presumably by secreting diffusible factors whose target sites are accessible from the third ventricle of the hypothalamus. (nih.gov)
  • To find SCN-secreted factors not previously documented, a hamster SCN cDNA library was screened in a yeast signal sequence trap. (nih.gov)
  • Fibroblast subpopulations enriched in Acta2 expression, expressed high levels of Wnt5a along with several other secreted factors including Tgfb1 , Tgfb2 and Ctgf . (aacrjournals.org)
  • The existence of a large number of secrete helmets of a very similar type all stored together in the Tower of London suggests that they were occasionally issued to troops as a uniform piece of military equipment. (wikipedia.org)
  • The secrete was usually a small skull-cap of iron or steel pierced around its rim. (wikipedia.org)
  • Secreted by the liver, bile is composed largely of bile salts, bile pigments and small amounts of organic materials such as cholesterol, lecithin, fatty acid and mucin. (cdc.gov)
  • Secreted phospholipases A 2 (sPLA 2 s) participate in a very broad spectrum of biological processes through their enzymatic activity and as ligands for membrane and soluble receptors. (ijbs.com)
  • 1996) and were found capable of secreting neurotransmitters (Elwan and Sakuragawa, 1997). (scielo.org.ar)
  • MacAB homologs in pseudomonads secrete products of nonribosomal peptide synthesis (NRPS). (ku.edu)
  • The secrete or secret, a French term adopted into English usage, was a type of helmet designed to be concealed beneath a hat. (wikipedia.org)
  • Baker, Sharon Felicity (1998) Studies of the interfacial and heparin binding properties of secreted phospholipases A2. (soton.ac.uk)