• In this study, we investigated the role of autophagy in glibenclamide-induced insulin secretion in pancreatic β cells. (hindawi.com)
  • Thus, SUs can close the K ATP channel in pancreatic β cells, followed by membrane depolarization and open the voltage-dependent Ca 2+ channels (VDCCs) to increase intracellular calcium (Ca 2+ ), resulting in insulin secretion and decreasing blood glucose [ 4 - 6 ]. (hindawi.com)
  • Also, vitamin D reduced the incidence of T1DM, enhanced insulin secretion, and relieved pancreatic inflammation in STZ-treated mice via enhancing autophagy in pancreatic β cells [ 10 ]. (hindawi.com)
  • The dynamics of insulin secretion can be studied at different levels: the single β cell, pancreatic islet, whole pancreas, and the intact organism. (jci.org)
  • Gastric acid aids digestion by creating the optimal pH for pepsin and gastric lipase and by stimulating pancreatic bicarbonate secretion. (merckmanuals.com)
  • Previous studies on the pathogenesis of T2D mainly focused on pancreatic β-cells function and insulin secretion regulation. (researchsquare.com)
  • Rab proteins are known to be important participants in insulin secretion by pancreatic β cells. (researchsquare.com)
  • In our previous study ( 16 ) , we found that Rab35 is closely related to the insulin secretion in pancreatic β cells, and Rab35 might be the target of miR-720 in pancreatic β cells. (researchsquare.com)
  • In pancreatic β-cells, the active of voltage-gated calcium (CaV) channels play an essential role in the glucose-stimulated insulin secretion (GSIS). (lu.se)
  • These results suggest that glibenclamide-induced autophagy plays an inhibitory role in promoting insulin secretion by activating the AMPK pathway instead of altering the mammalian target of rapamycin (mTOR). (hindawi.com)
  • Disease and disorder research has been conducted in relation to the Gastric Acid Secretion Pathway and Ulcer, Duodenal Ulcer, Gastric Ulcer, Peptic Ulcer, Gastroesophageal Reflux Disease. (novusbio.com)
  • The study of the Gastric Acid Secretion Pathway has been mentioned in research publications which can be found using our bioinformatics tool below. (novusbio.com)
  • The Gastric Acid Secretion Pathway has been researched in relation to Acid Secretion, Secretion, Gastric Emptying, Regulation Of Gastric Acid Secretion, Pathogenesis. (novusbio.com)
  • The Gastric Acid Secretion Pathway complements our catalog of research reagents including antibodies and ELISA kits against GAST, SST, CCK, INS, CCKBR. (novusbio.com)
  • We have 1582 products for the study of the Gastric Acid Secretion Pathway that can be applied to Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry, Western Blot from our catalog of antibodies and ELISA kits. (novusbio.com)
  • However, the current best practices method of T3SS pathway activation for secretion is not ideal for industrial scaleup. (biorxiv.org)
  • Increase of miR-720 reduced Rab35 expression then activate PI3K/Akt/mTOR signal pathway, thus inhibiting insulin secretion. (researchsquare.com)
  • In this study we sought to elucidate which signaling pathway(s) are involved in LPA-mediated secretion of uPA from ovarian cancer cells. (spandidos-publications.com)
  • In contrast, inhibitors of phospholipase D or the p70S6 kinase pathway did not alter LPA-induced uPA secretion. (spandidos-publications.com)
  • These results indicate that the p38MAPK signaling pathway is required for optimal LPA-dependent uPA secretion from ovarian cancer cells. (spandidos-publications.com)
  • Estrella VC, Eder AM, Liu S, Pustilnik TB, Tabassam FH, Claret FX, Gallick GE, Mills GB and Wiener JR: Lysophosphatidic acid induction of urokinase plasminogen activator secretion requires activation of the p38MAPK pathway. (spandidos-publications.com)
  • Moreover, this secretion system is part of an antioxidant regulatory pathway linked to Zinc . (bvsalud.org)
  • Vaginal secretions are how the vagina cleanses and regulates itself -- how amazing is that? (scarleteen.com)
  • However, the intracellular signal that regulates cytokine secretion in bone marrow stromal cells has not been determined. (unboundmedicine.com)
  • Moreover, JCPyV and BKPyV viral DNA has been detected in tonsils ( 5 , 6 ), and BKPyV has been found in respiratory tract secretions ( 7 ). (cdc.gov)
  • We hypothesized that presence in the upper respiratory tract is a trait shared by all human PyVs and investigated whether MCPyV could also be found in respiratory secretions. (cdc.gov)
  • Excessive respiratory secretions result when the person becomes too weak to clear their airways in the last days of life. (bpac.org.nz)
  • In the last days of life, excessive respiratory secretions accumulate in the airways when the person no longer has the awareness or energy to clear the fluid. (bpac.org.nz)
  • Excessive respiratory secretions can be classified as either Type I, caused by salivary secretions or Type II, caused by the build-up of fluid in the lungs. (bpac.org.nz)
  • 3 Other contributory factors to excessive respiratory secretions include heart failure, cardiac dysfunction, discontinuation of corticosteroid treatment (for raised intracranial pressure), neuromuscular disorders, e.g. myasthenia gravis, head and neck cancers and brain tumours. (bpac.org.nz)
  • Reassure family/whānau that the noises made in response to respiratory secretions are not signs that their loved one is in distress, but a normal part of the dying process. (bpac.org.nz)
  • The in vitro effects of dimethyl sulfoxide (DMSO) extract of Turkish propolis on the secretion of PMN elastase from PMNLs following respiratory burst was studied. (tubitak.gov.tr)
  • Excess acetylcholine produces a predictable cholinergic syndrome consisting of copious respiratory and oral secretions, diarrhea and vomiting, sweating, altered mental status, autonomic instability, and generalized weakness that can progress to paralysis and respiratory arrest. (cdc.gov)
  • We conclude that surface epithelium is responsible for most HA and all KS present in secretions, whereas glands secrete most of CS/DS. (nih.gov)
  • These data suggest that, in diseases where the contribution to secretions of glands versus epithelial cells is altered, the relative concentration of individual GAGs, and therefore their biological activities, will also be affected. (nih.gov)
  • It's astonishing to think that the most recent vinyl full length outing from Glands of External Secretion was the splendiferous Reverse Atheism 2xLP (Butte County Free Music Society, 2011). (midheaven.com)
  • If unfamiliar, Glands Of External Secretion are the duo of Barbara Manning (28th Day, World Of Pooh, SF Seals) and S. Glass (Bananafish Magazine, many things BuFMS). (midheaven.com)
  • What controls the rate and force of the heart beat the secretion of glands of the alimentary tract? (answers.com)
  • Bacterial flagella contain a specialized secretion apparatus that functions to deliver the protein subunits that form the filament and other structures to outside the membrane 1 . (nature.com)
  • The Salmonella pathogenicity island 1 type III secretion system (T3SS) is a protein secretion complex in Salmonella that has been engineered to secrete heterologous proteins and addresses the problems associated with bacterial protein production. (biorxiv.org)
  • Dashed boxes indicate the proteins that function in flagellar secretion, either in the membrane-bound part of the apparatus or in delivery of substrate. (nature.com)
  • Measurement of soluble proteins in lung secretions. (bmj.com)
  • T3S assays performed with T3S-competent Y. enterocolitica or with an isogenic T3S-deficient strain individually expressing the TEM-1 fusions revealed a statistically significant higher level of secretion of 22 fusion proteins relative to RplJ20-TEM-1. (europa.eu)
  • Thirteen proteins showed a statistically significant higher level of secretion than full-length C. trachomatis RplJ. (europa.eu)
  • We also tested secretion of 11 out of these 13 proteins when expressed from an arabinose-inducible promoter in Y. enterocolitica, which revealed T3S-dependent secretion of 7 proteins. (europa.eu)
  • The results show that insulin exerts a direct, specific inhibitory effect on basal and hydrocortisone-induced GH secretion by GH3 cells unrelated to glucose utilization by the cells. (jci.org)
  • British Library EThOS: Neurogenic mucus secretion in ferret trachea : excitatory and inhibitory control. (bl.uk)
  • TY - JOUR T1 - Role of mitogen-activated protein kinase family in serum-induced leukaemia inhibitory factor and interleukin-6 secretion by bone marrow stromal cells. (unboundmedicine.com)
  • These findings show that the flagellar secretion apparatus functions as a proton-driven protein exporter and that ATP hydrolysis is not essential for type III secretion. (nature.com)
  • an invasion protein associated with the type-III secretion system of Burkholderia pseudomallei. (rcsb.org)
  • Burkoldheria pseudomallei is a Gram-negative bacterium that possesses a protein secretion system similar to those found in Salmonella and Shigella. (rcsb.org)
  • BipD is similar in sequence to IpaD from Shigella and SipD from Salmonella and is therefore likely to be a translocator protein in the type-III secretion system of B. pseudomallei. (rcsb.org)
  • We solve this problem by engineering the Salmonella pathogenicity island 1 type III secretion system (T3SS) to export the target protein into the cell growth media. (biorxiv.org)
  • We tested the hypothesis that protein kinase C (PKC) participates in stimulus-secretion coupling. (jneurosci.org)
  • The aim of this study was to evaluate the role of mitogen-activated protein kinase (MAPK) family in serum-induced secretion of LIF and IL-6 by bone marrow stromal cells. (unboundmedicine.com)
  • Mycobacteria possess specialized protein secretion systems , such as the Early Secretory Antigenic Target 6 secretion (ESX) system. (bvsalud.org)
  • A similar reduction of ↑[Ca 2+ ] e -evoked secretion was produced by inhibitors of conventional and/or novel PKCs (Gö6976, calphostin C, and pseudoA), and these compounds did not inhibit secretion at all when applied to phorbol-downregulated cells. (jneurosci.org)
  • or steady state intestinal perfusion which allows detailed examination of mucosal absorption or secretion rate in the jejunum, ileum and colon. (usda.gov)
  • We suggest that PKC isoforms mediate secretion of 5-HT by PF cells in response to stimulation of the CaR. (jneurosci.org)
  • Single cell spike rate and secretion response to increasing synaptic stimulation. (figshare.com)
  • [ 16 ] The syndrome appears to arise because of excessive water consumption during the physical exercise coupled with loss of sodium chloride in sweat and nonosmotic stimulation of AVP secretion (from stress, volume contraction, nausea, and NSAIDs). (medscape.com)
  • Here we show that flagellar secretion in Salmonella enterica requires the proton motive force (PMF) and does not require ATP hydrolysis by FliI. (nature.com)
  • Some evidence for a different view has also been reported: it was observed that type III secretion in Yersinia enterocolitica was prevented by the protonophore CCCP 7 , and it was shown that the secretion ATPase InvC of Salmonella functions to dissociate export substrate from the chaperone 8 , a role distinct from transport itself. (nature.com)
  • We have demonstrated previously that oleoyl (18:1) LPA at concentrations present in ascites induces the secretion of urokinase plasminogen activator (uPA) from ovarian cancer cells, possibly linking LPA to cellular invasion. (spandidos-publications.com)
  • Finally, LPA induces uPA secretion from ovarian cancer cells predominantly through the LPA2 receptor, with LPA3 contributing to this process. (spandidos-publications.com)
  • More and more evidences ( 6 - 8 ) show that miRNAs are involved in the regulation of glucose metabolism, insulin synthesis and secretion, which are the core links in the development of T2D. (researchsquare.com)
  • This review provides an overview of new findings on the ESX-3 secretion system, its regulation , expression, and functions. (bvsalud.org)
  • Studies have begun to analyze cellular and molecular mechanisms underlying dynamics of insulin secretion. (jci.org)
  • This study aimed to investigate whether miR-720 targets Rab35 to regulate insulin secretion in MIN6 cells and its molecular mechanism, and the clinical value of miR-720 as a specific biomarker of T2D. (researchsquare.com)
  • Therefore, the aim of the current study was to investigate whether miR-720 targets Rab35 to regulate insulin secretion in MIN6 cells and its molecular mechanism, and the clinical value of miR-720 as a specific biomarker of T2D. (researchsquare.com)
  • An abnormal increase in blood glucose may be due to a defect in insulin self-secretion caused by the immune system (type 1 diabetes mellitus, T1DM), or resistance to the cellular effects of insulin, as well as insufficient insulin secretion (type 2 diabetes mellitus, T2DM) [ 1 ]. (hindawi.com)
  • Previous studies have shown that glibenclamide can improve insulin secretion at low-normal glucose, which may increase the risk of hypoglycemia when attempting to maintain tight glucose control [ 8 ]. (hindawi.com)
  • Diabetes is a highly ageing-related disease manifesting with a deteriorated capacity of insulin secretion and uncontrolled blood glucose-raising, hyperglycemia. (lu.se)
  • By inhibiting prostaglandin production via blockage of the enzyme cyclooxygenase (COX), NSAIDs reduce gastric blood flow, reduce mucus and HCO3 secretion, and decrease cell repair and replication. (merckmanuals.com)
  • Although phorbol downregulation caused PKCγ to disappear, secretion was only partially inhibited. (jneurosci.org)
  • In contrast, the phorbol downregulation-resistant component of secretion was abolished by pseudoZ, which inhibits the atypical PKCζ. (jneurosci.org)
  • Overexpression of miR-720 inhibited insulin secretion and miR-720 downregulation promoted insulin secretion. (researchsquare.com)
  • Fig. 6: Excessive glucagon secretion by transplanted T2D islets in GKO-NSG mice. (nature.com)
  • Pharmacological treatment is usually only considered if the patient is unconscious (or semi-conscious) and the excessive secretions are impacting their care or causing distress for the family/whānau. (bpac.org.nz)
  • Patients and Methods: Eleven patients with ocular prostheses participated in an assessment of clinical infection and the collection of conjunctival secretion. (bvsalud.org)
  • moreover, PI3′-kinase inhibitors (wortmannin and LY294002) antagonized secretion. (jneurosci.org)
  • Inhibition of p38MAPK signaling by SB202190 completely abrogated LPA-induced uPA secretion, while inhibition of the p42/44MAPK or PI3K pathways with PD98059 or wortmannin and LY294002, respectively, decreased but did not completely block uPA secretion. (spandidos-publications.com)
  • We study the physiology of absorption/secretion, the pathophysiology of diarrhea and malabsorption, and we study patients with intractable diarrhea/malabsorption. (usda.gov)
  • Current techniques for nasal secretions sampling are mainly based on three principles: collection of spontaneous secretions, nasal washings, and absorption. (medscape.com)
  • Specific inhibitors were utilized to determine if interference with the p38MAPK, p42/44MAPK, and PI3K pathways functionally blocked LPA-mediated uPA secretion. (spandidos-publications.com)
  • By contrast the phasic model shows a very linear response up to ∼4 Hz, after which secretion becomes relatively independent of mean spike rate. (figshare.com)
  • ABSTRACT Anti-zona-pellucida autoantibodies (AZP-Ab) and anti-sperm isoantibodies (ASA) were as- sessed in the cervical secretions from 73 infertile Jordanian women and 41 fertile control women using latex agglutination. (who.int)
  • Major concerns are the inconsistent data on biomarker concentrations as their low concentration in secretions. (medscape.com)
  • Together, these data suggest the involvement of PARK9 in the biogenesis of exosomes and α-syn secretion and raise a possibility that disruption of these pathways in patients with KRS contributes to the disease pathogenesis. (nih.gov)
  • The suppression of GH secretion was reversible, as removal of added insulin resulted in return of GH secretion to normal levels after 24 h. (jci.org)
  • Maximal suppression of basal GH secretion was achieved by 0.7 nM insulin, and these effects were prevented by simultaneous exposure of the cells to guinea pig anti-insulin serum (1:2,000). (jci.org)
  • Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a condition in which the body makes too much antidiuretic hormone (ADH). (medlineplus.gov)
  • The syndrome of inappropriate antidiuretic hormone secretion (SIADH) involves the continued secretion or action of arginine vasopressin (AVP) despite normal or increased plasma volume. (medscape.com)
  • Little is known about regulated glucagon secretion by human islet α-cells compared to insulin secretion from β-cells, despite conclusive evidence of dysfunction in both cell types in diabetes mellitus. (nature.com)
  • The analysis of human secretions, such as nasal fluid and tears, provide valuable information on pathophysiological aspects of allergic diseases. (medscape.com)
  • This review focuses on our current understanding of the dynamics of insulin secretion in vitro and in vivo and discusses their clinical relevance. (jci.org)
  • Then we used miR-720 mimic, miR-720 inhibitor and dual luciferase reporter gene assays to prove miR-720 regulate insulin secretion by targeting Rab35 in MIN6 cells. (researchsquare.com)
  • In summary, we investigate the mechanisms regulating insulin production and secretion through Cav channels and DEGs. (lu.se)
  • And so, if you are suffering from anxiety, and the thought of the drinking the anal secretions of a beaver somehow does not exacerbate your anxiousness, you might want to try some castoreum. (boingboing.net)
  • Does Your Food Contain Beaver Anal Secretions? (boingboing.net)
  • Weak swarming motility and rare flagella were observed in a mutant deleted for FliI and for the non-flagellar type-III secretion ATPases InvJ and SsaN. (nature.com)
  • Homologues of FliI also occur in the type III secretion apparatus of injectisomes and are usually assumed to energize export in those systems as well. (nature.com)
  • The energy source for type III secretion thus remains uncertain. (nature.com)
  • To address the energy requirements for type III secretion, we first measured the effect of the uncoupler CCCP on flagellar export in S. enterica , assayed by accumulation of the export substrate FlgM in the medium. (nature.com)
  • For this, specifically we aimed to (i) identify novel C. trachomatis type III secretion (T3S) effectors and (ii) further understand the secretion and function of known effectors. (europa.eu)
  • The numerous functions of saliva, like antimicrobial activity, lubrication, wound healing and its role in taste experience are only truly recognized when saliva secretion is hampered. (karger.com)
  • The collection procedure of nasal and ocular secretions directly influences the results, thus it is of paramount importance to validate and standardize the sampling process. (medscape.com)
  • Patients may have symptoms that suggest increased secretion of AVP, such as chronic pain, symptoms from central nervous system or pulmonary tumors or head injury, or drug use. (medscape.com)
  • More products containing human secretions and body parts are still being developed today. (listverse.com)
  • Fig. 2: Transplanted human islets retain regulated glucagon secretion in GKO-NSG mice. (nature.com)
  • Stress-impaired transcription factor expression and insulin secretion in transplanted human islets. (nature.com)
  • Secretion of pituitary-like peptides by the human placenta. (bmj.com)
  • 4 In most cases, suction is unlikely to be beneficial, and it can increase secretions and damage the oropharynx/laryngopharynx. (bpac.org.nz)
  • In summary, HTA samples contain KS, CS/DS, and HA, mirroring a mixture of secretions originated in surface epithelial cells and SMGs. (nih.gov)
  • Insulin suppresses growth hormone secretion by rat pituitary cells. (jci.org)
  • The effects of insulin on basal and hydrocortisone-induced growth hormone (GH) secretion were studied in rat pituitary tumor cells (GH3). (jci.org)
  • Basal GH secretion was inhibited by insulin (0.7 nM) after a 48-h lag period by approximately 50% (P less than 0.01, vs. untreated control cells). (jci.org)
  • Glibenclamide is known to promote insulin secretion by targeting β cells. (hindawi.com)
  • We increased and decreased miR-720 expression using miR-720 mimic and inhibitor to identify the effect of miR-720 on insulin secretion in MIN6 cells, respectively. (researchsquare.com)
  • miR-720 regulated insulin secretion by targeting Rab35 in MIN6 cells. (researchsquare.com)
  • E ) Secretion per spike shows that secretion from phasic cells is achieved with much greater efficiency at synaptic input rates exceeding 200 Hz with optimal efficiency at about 400-600 Hz, corresponding to mean firing rates of 2-4 spikes/s (comprising relatively short sparse bursts). (figshare.com)
  • The present study aimed to clarify the role of NKB-neurokinin 3 receptor (NK3R) signaling in the pulsatile pattern of GnRH/gonadotropin secretion in postpartum lactating cattle.We examined the effects of the administration of an NK3R-selective agonist, senktide, on gonadotropin secretion in lactating cattle. (bioone.org)
  • The effectiveness of pharmacological treatments is limited and they do not remove secretions already present, so prioritise reassurance of the family and non-pharmacological interventions. (bpac.org.nz)
  • [ 9 ] The present review aims to get an overview on the most common methods of nasal secretions and tears sampling and on testing of their content in immunoglobulin E (IgE) and other mediators. (medscape.com)
  • The phasic secretion profile (right) shows an initial steep increase which slows as the intra-burst spike rate reaches the optimal response frequency, and longer bursts allow less recovery from fatigue. (figshare.com)
  • D ) Examining secretion against spike rate the non-phasic model shows a progressive increase in secretion with increasing frequency. (figshare.com)