Femoral head osteonecrosisNeuralgia-inducing cavitational osteBoneSteroid-inducedMedication-relatedAtraumatic osteonecrosisFracturesEtiology2018NontraumaticMRONJ2017Aseptic NecrosisArthroplastyJawsApoptosisOsteoporosisBisphosphonatesONFH1968MandibleDislocationCorticosteroidsMorbidityCommonlyPatientsKneeMechanismSubchondralOralDiseaseTreatmentCommonAdverseCollapseStudyCasesBlood
Femoral head osteonecrosis3
- Effects of sodium ferulate on preventing steroid-induced femoral head osteonecrosis in rabbits[J]. Journal of Zhejiang University Science B, 2013, 14(5): 426-437. (zju.edu.cn)
- The aim of this study is to investigate the effects and possible mechanisms of sodium ferulate (SF) on anti- apoptosis in steroid-induced femoral head osteonecrosis in rabbit s. (zju.edu.cn)
- Scaglione M, Fabbri L, Celli F, Casella F, Guido G (2015) Hip replacement in femoral head osteonecrosis: current concepts. (sicot-j.org)
Neuralgia-inducing cavitational oste3
- Also called Ratner's bone cavity, a neuralgia-inducing cavitational osteonecrosis was first described in dental literature by G V Black in 1920. (wikipedia.org)
- AAE Position Statement on NICO lesions (Neuralgia-Inducing Cavitational Osteonecrosis)" (PDF). (wikipedia.org)
- They have been variably labeled as Ratner, Roberts, or trigger point bone cavities, interference fields, neuralgia-inducing cavitational osteonecrosis (NICO), and alveolar cavitational osteopathosis. (livingnetwork.co.za)
Bone23
- Forty patients (60 hips) with stage I, II or III (ARCO system) osteonecrosis of femoral head were treated by either core decompression and isolated mononuclear cells (group A) or core decompression and unprocessed bone marrow injection (group B). The patients were followed up clinically and radiologically for a minimum of 2 years. (nih.gov)
- Medication-related osteonecrosis of the jaw (MRONJ) is an adverse drug reaction, described as an exposed necrotic bone or a bone that can be probed through an intraoral or extraoral fistula in the maxillofacial region, that persists for more than 8 weeks in patients without a history of radiotherapy or disease metastasis to the jaws ( 1 , 2 ). (frontiersin.org)
- [ 16 ] A study analyzed the clinical, functional and radiological outcome of core decompression and bone grafting in 20 patients with 28 cases of osteonecrosis of the femoral head (ONFH) up to stage IIB (Ficat & Arlet). (medscape.com)
- Aim: This study aimed to systematically review existing literature regarding the association between dental procedures-such as tooth extractions and periodontal therapy-and occurrence of medication-related osteonecrosis of the jaw (MRONJ) in individuals using bone-modifying drugs. (unicamp.br)
- Roles of periosteum, dura, and adjacent bone on healing of cranical osteonecrosis. (acibadem.com.tr)
- J Bone Joint Surg Am 90(10):2160-2170. (springer.com)
- J Bone Joint Surg Br 93(5):587-592. (springer.com)
- J Bone Joint Surg Br 92(9):1231-1237. (springer.com)
- Osteonecrosis of the femoral head (ONFH) is also defined as avascular necrosis or aseptic necrosis, which is characterized by impaired blood flow to the bone due to trauma or non-traumatic blood flow, resulting in bone cell death[1, 2]. (researchsquare.com)
- Osteonecrosis of the knee is commonly mistaken for osteochondritis dissecans, primary osteoarthritis, meniscal tears, bone bruises, transient osteopenia of the knee, and pes anserine bursitis. (medscape.com)
- J Bone Joint Surg Am. 2011 Jul 6;93(13):1197-1202. (cgmh.org.tw)
- J Bone Joint Surg Am. 2011 Feb;93(3):274-84. (cgmh.org.tw)
- Osteonecrosis is a focal infarct of bone that may be caused by specific etiologic factors or may be idiopathic. (msdmanuals.com)
- However, in recent years, the literature pointed out that patients using anti-bone resorption drugs may have adverse reactions to maxillofacial osteonecrosis. (peertechzpublications.com)
- Steroid-induced osteonecrosis of the femoral head (SONFH) is the necrosis of the femur bone caused by prolonged and massive use of corticosteroids. (biomedcentral.com)
- The pathogenesis of SONFH is associated with increased intraosseous pressure caused by increased adipocyte proliferation and adipogenesis in the bone marrow, which can slow blood flow in the femoral head and eventually lead to ischemic osteonecrosis [ 4 ]. (biomedcentral.com)
- Medication-related osteonecrosis of the jaw (MRONJ) is a devastating pathology that occurs in a small fraction of patients taking antiresorptive or antiangiogenic drugs for the treatment of certain bone pathologies. (decisionsindentistry.com)
- 11 Osteonecrosis is classically associated with decreased blood flow to the affected bone, and the function of these medications likely contributes to MRONJ. (decisionsindentistry.com)
- Medication-related osteonecrosis of the jaw (MRONJ) is a drug-related adverse event consisting of progressive bone destruction in the maxillofacial region of patients under current or previous treatment with antiresorptive or antiangiogenic medications. (cellsindentistry.org)
- Upon chronic usage, patients may experience serious problems like osteonecrosis of the jaw and atypical bone fractures. (ac.ir)
- Bone marrow oedema (BME) and avascular osteonecrosis (AVN) are disorders of unclear origin. (biomedcentral.com)
- Wang BL, Sun W, Shi ZC, Zhang NF, Yue DB, Guo WS, Shi S-H, Li ZR (2010) Treatment of nontraumatic osteonecrosis of the femoral head using bone impaction grafting through a femoral neck window. (sicot-j.org)
- J Bone Joint Surg Am 77, 459-474. (sicot-j.org)
Steroid-induced2
- [ 4 ] Fat cell hypertrophy with resultant pressure increase within the femoral head, leading to vascular collapse and then necrosis, has been proposed as a mechanism for steroid-induced osteonecrosis. (medscape.com)
- One of the most common and serious complications caused by steroid therapy is steroid-induced osteonecrosis of the femoral head (SONFH) [ 2 ]. (biomedcentral.com)
Medication-related11
- Nonsurgical Management of Medication-Related Osteonecrosis of the Jaws Using Local Wound Care. (bvsalud.org)
- Medication-related osteonecrosis of the jaws (MRONJ) is a known complication of antiresorptive medications with surgical and nonsurgical treatment options. (bvsalud.org)
- This systematic review was performed to assess the potential influence of medication-induced salivary changes on the development of medication-related osteonecrosis of the jaw (MRONJ). (frontiersin.org)
- American association of oral and maxillofacial surgeons position paper on medication-related osteonecrosis of the jaw - 2014 update. (unicamp.br)
- The clinical patterns of adverse drug reactions of the oral cavity include xerostomia, swelling, nonspecific ulceration, vesiculobullous or ulcerative mucositis that mimics other disease states, nonspecific vesiculoulcerative mucositis, pigmentation, gingival enlargement, and medication-related osteonecrosis of the jaws. (medscape.com)
- Medication-Related Osteonecrosis of the Jaw (MRONJ) may occur in patients with osteoporosis and tumors. (peertechzpublications.com)
- Medication-Related Osteonecrosis of the Jaw (MRONJ) is a rare, severe debilitating condition from unknown causes. (peertechzpublications.com)
- Discuss the causes of and risk factors for medication-related osteonecrosis of the jaw (MRONJ). (decisionsindentistry.com)
- As a consequence, in 2014, the American Association of Oral and Maxillofacial Surgeons (AAOMS), introduced the term medication-related osteonecrosis of the jaw (MRONJ). (cellsindentistry.org)
- Changes in epidemiological characteristics of patients diagnosed with medication related osteonecrosis of the jaw (MRONJ). (pearldental.co.il)
- Vitamin D (25-OHD) deficiency may increase the prevalence of medication-related osteonecrosis of the jaw. (estmjs.org)
Atraumatic osteonecrosis6
- Traumatic and atraumatic osteonecrosis are essentially 2 distinct problems. (medscape.com)
- The main focus of this article is atraumatic osteonecrosis. (medscape.com)
- The natural history of atraumatic osteonecrosis is still not well understood. (medscape.com)
- The pathophysiology in atraumatic osteonecrosis remains controversial. (medscape.com)
- [ 5 ] Studies have also shown elevated cryofibrinogen levels in atraumatic osteonecrosis. (medscape.com)
- The natural history of the silent hip in bilateral atraumatic osteonecrosis. (zju.edu.cn)
Fractures2
- osteonecrosis is uncommon after intertrochanteric fractures. (msdmanuals.com)
- Despite the wide availability of bisphosphonate drugs that reduce fracture risk, treatment rates have fallen, attributable to concerns for atypical femoral fractures and osteonecrosis of the jaw. (kaiserpermanente.org)
Etiology1
- Although the etiology of secondary osteonecrosis is unknown, several risk factors are associated with the disease. (medscape.com)
20182
- J Oral Maxillofac Surg;76(11): 2332-2339, 2018 11. (bvsalud.org)
- Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Jan;125(1):27-30. (unicamp.br)
Nontraumatic4
- The most common cause of osteonecrosis is trauma, and the most common cause of nontraumatic osteonecrosis is corticosteroid use. (msdmanuals.com)
- Nontraumatic osteonecrosis of the femoral head (NONFH) is a common, progressive, and refractory orthopaedic disease. (biomedcentral.com)
- The NONFH exosomal miR-100-5p can lead to NONFH-like damage by targeting BMPR2 and suppressing the BMPR2/SMAD1/5/9 signalling pathway, which may be involved in the pathophysiological mechanisms of nontraumatic osteonecrosis of the femoral head (NONFH). (biomedcentral.com)
- Free vascularized fibula graft (FVFG) techniques have most consistently demonstrated beneficial effects in young patients diagnosed with nontraumatic osteonecrosis of the femoral head (NONFH), and the core track technique (CTT) in particular is the most commonly used technique. (biomedcentral.com)
MRONJ3
- MRONJ has characteristics that differ from osteonecrosis at other sites. (msdmanuals.com)
- Then bisphosphonate-related osteonecrosis of the jaw described this condition until newer, nonbisphosphonate medications were implicated, resulting in MRONJ as the currently accepted term. (decisionsindentistry.com)
- The adjunct of APC in MRONJ treatment significantly reduced osteonecrosis recurrence with respect to control ( P = 0.001). (cellsindentistry.org)
20171
- Martz P, Maczynski A, Elsair S, Labattut L, Viard B, Baulot E (2017) Total hip arthroplasty with dual mobility cup in osteonecrosis of the femoral head in young patients: over ten years of follow-up. (sicot-j.org)
Aseptic Necrosis1
- For patient education information, see Avascular Necrosis (Aseptic Necrosis or Osteonecrosis) . (medscape.com)
Arthroplasty3
- Floerkemeier T, Tscheuschner N, Calliess T, Ezechieli M, Floerkemeier S, Budde S, Windhagen H, von Lewinski G (2012) Cementless short stem hip arthroplasty METHA(R) as an encouraging option in adults with osteonecrosis of the femoral head. (springer.com)
- Ortiguera CJ, Pulliam IT, Cabanela ME (1999) Total hip arthroplasty for osteonecrosis: matched-pair analysis of 188 hips with long-term follow-up. (sicot-j.org)
- Johannson HR, Zywiel MG, Marker DR, Jones LC, McGrath MS, Mont MA (2011) Osteonecrosis is not a predictor of poor outcomes in primary total hip arthroplasty: a systematic literature review. (sicot-j.org)
Jaws1
- Osteonecrosis of the jaws associated with the use of bisphosphonates: a review of 63 cases. (unicamp.br)
Apoptosis1
- The apoptosis rate of osteonecrosis was observed by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay. (zju.edu.cn)
Osteoporosis1
- Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a rare and severe adverse drug side effect that may occur in cancer and osteoporosis patients being treated with bisphosphonate medications. (cellsindentistry.org)
Bisphosphonates1
- Yarom N, Lazarovici TS, Whitefield S, Weissman T, Wasserzug O, Yahalom R. Rapid onset of osteonecrosis of the jaw in patients switching from bisphosphonates to denosumab. (unicamp.br)
ONFH3
- Cellular therapy based on mesenchymal stem cells (MSCs) is a promising novel therapeutic strategy for the osteonecrosis of the femoral head (ONFH), which is gradually becoming popular, particularly for early-stage ONFH. (biomedcentral.com)
- Osteonecrosis of the femoral head (ONFH) is a progressive and refractory disease that is common in orthopedics. (biomedcentral.com)
- Osteonecrosis of the femoral head (ONFH) is still a challenge for orthopedists worldwide, which may lead to disability in patients without effective treatment. (researchsquare.com)
19682
- Ahlback et al first reported on osteonecrosis of the knee in 1968. (medscape.com)
- Arlet J, Ficat P, Lartigue G (1968) Mode of onset of primary osteonecrosis of the femoral head. (sicot-j.org)
Mandible2
- Osteonecrosis of the mandible associated with bevacizumab therapy. (unicamp.br)
- RESULTS: After 4months of radiotherapy, both sides of mandible displayed preclinic symptom of radiative osteonecrosis. (avmi.net)
Dislocation2
- The incidence of osteonecrosis after hip dislocation is related primarily to the severity of the initial injury but may be higher if the dislocation is not promptly reduced. (msdmanuals.com)
- Fracture or dislocation may cause osteonecrosis by grossly disrupting or compressing nearby blood vessels. (msdmanuals.com)
Corticosteroids1
- The mechanism by which corticosteroids contribute to osteonecrosis also is unclear. (medscape.com)
Morbidity1
- Osteonecrosis is now a commonly recognized disorder with significant morbidity. (medscape.com)
Commonly2
- It is unusual for osteonecrosis to involve the shoulder or other less commonly affected sites without the hip also being involved. (msdmanuals.com)
- Therefore, among the etiologies of osteonecrosis, both of them were commonly considered to have the same pathogenesis. (biomedcentral.com)
Patients8
- Unfortunately, patients who are affected with osteonecrosis are young, usually in the third to sixth decades of life. (medscape.com)
- Prostheses with novel bearing surfaces (ie, metal-on-metal, ceramic-on-ceramic) are being investigated, to increase the success rate for total hip replacements in patients with osteonecrosis. (medscape.com)
- Practical guidelines for the prevention, diagnosis, and treatment of osteonecrosis of the jaw in patients with cancer. (unicamp.br)
- In the United States, osteonecrosis affects approximately 20,000 new patients annually. (msdmanuals.com)
- We designed a case-control study including 429 patients of osteonecrosis and 368 age- and sex-matched control subjects. (biomedcentral.com)
- A of ApoAI gene and EcoR I, Xba I and 3′-VNTR of ApoB gene in osteonecrosis patients and healthy controls. (biomedcentral.com)
- All the patients were consistent with the diagnostic criteria of osteonecrosis proposed in 1995 by Mont et al. (biomedcentral.com)
- Cornell CN, Salvati EA, Pellicci PM (1985) Long-term follow-up of total hip replacement in patients with osteonecrosis. (sicot-j.org)
Knee7
- Knee Surg Sports Traumatol Arthrosc. (mayo.edu)
- Osteonecrosis of the knee has been divided into two separate entities: spontaneous osteonecrosis of the knee (SPONK) and secondary osteonecrosis. (medscape.com)
- [ 3 ] The osteonecrosis that Ahlback described now is referred to as spontaneous osteonecrosis of the knee (SPONK). (medscape.com)
- The knee is the second most common site for osteonecrosis, but it is affected much less often than the hip. (medscape.com)
- The true incidence of the disease is unknown, but osteonecrosis of the knee is believed to account for approximately 10% of cases of osteonecrosis. (medscape.com)
- The etiologies of both spontaneous osteonecrosis of the knee (SPONK) and secondary osteonecrosis are poorly understood. (medscape.com)
- Clinical presentation of spontaneous osteonecrosis of the knee (SPONK) and secondary osteonecrosis is summarized in the following table. (medscape.com)
Mechanism1
- However, the specific mechanism of osteonecrosis of the femoral head has not been fully elucidated. (biomedcentral.com)
Subchondral1
- In osteonecrosis, the lesion can extend to the subchondral plate and result in collapse of the necrotic segment. (medscape.com)
Oral4
- Oral Surg. (wikipedia.org)
- Oral Surg Oral Med Oral Pathol Oral Radiol. (unicamp.br)
- Strontium ranelate treatment in a postmenopausal woman with osteonecrosis of the jaw after long-term oral bisphosphonate administration: a case report. (cgmh.org.tw)
- The literature for nearly 20 years has shown that long-term use of such antiresorptive drugs increases the risk of osteonecrosis of the jaw in the oral cavity. (peertechzpublications.com)
Disease2
- Osteonecrosis is a disease characterized by a derangement of osseous circulation that leads to necrosis of osseous tissue. (medscape.com)
- Osteonecrosis is one kind of orthopedic refractory disease and is divided into traumatic and non-traumatic one. (biomedcentral.com)
Treatment3
- Osteonecrosis of the jaw is a poorly understood condition that has recently been associated with the use of potent bisphosphonate treatment. (peertechzpublications.com)
- The model and treatment groups were first injected with an intravenous dose of horse serum, 10 ml/kg, three weeks later with an intravenous dose of 7.5 ml/kg, and two weeks later with an intramuscular dose of methylprednisolone, 45 mg/kg, three times in order to establish rabbit models of osteonecrosis. (zju.edu.cn)
- Bedard NA, Callaghan JJ, Liu SS, Greiner JJ, Klaassen AL, Johnston RC (2013) Cementless THA for the treatment of osteonecrosis at 10-year follow-up: have we improved compared to cemented THA? (sicot-j.org)
Common1
- There are 2 forms of osteonecrosis: traumatic (the most common form) and atraumatic. (medscape.com)
Adverse1
- Although BPs are effective and safe, they may cause GI adverse effects and rare cases of osteonecrosis. (ac.ir)
Collapse1
- Management of early stages of osteonecrosis aims to prevent the collapse of the femoral head by attempts at restoring the vascularity of femoral head. (nih.gov)
Study1
- To further clarify the association of ApoAI and ApoB genetic polymorphism and osteonecrosis, we designed a larger sample-size case-control study. (biomedcentral.com)
Cases1
- Currently, the whole population of osteonecrosis is about 7 million people in China, and new cases have reached 100-200 thousand each year [ 2 ]. (biomedcentral.com)
Blood1
- Traumatic osteonecrosis is a direct result of disruption of the blood supply to the femoral head. (medscape.com)